Abstract: This invention provides a traditional Chinese medicine composition consisting of the extract of no more than five crude drugs, wherein crude drugs include licorice and also include Radix Scutellariae or Rhizoma Polygoni Cuspidati. In addition, this invention also provides the preparations, treatment methods, treatment applications and preparation methods of the above traditional Chinese medicine compositions.
Abstract: A method of cosmetic care comprising activating capsase-14 expression in skin deficient in caspase-14 expression by applying, on at least one skin zone in need thereof, an effective amount of a plant extract selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof, to activate caspase-14 expression in said skin.
Type:
Application
Filed:
March 8, 2011
Publication date:
September 13, 2012
Inventors:
Hugo A. Corstjens, Lieve Declercq, Gerry Eyckmans, Luc F.J. Van Overloop
Abstract: The present invention relates to compositions comprising an edible oil having improved oxidative stability and methods for manufacturing such compositions. The composition contains an active fraction of a green tea extract, partial glycerides in an amount of at least 2% and an edible oil. The partial glycerides may contain mono- and/or diglycerides and the edible oil may be a polyunsaturated oil, e.g. a fish oil.
Type:
Application
Filed:
July 20, 2010
Publication date:
August 30, 2012
Inventors:
Harald Breivik, Vidar Moen, Tanja Vojnovic
Abstract: The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachidonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
Type:
Grant
Filed:
December 29, 2008
Date of Patent:
August 28, 2012
Assignee:
New Chapter Inc.
Inventors:
Thomas Newmark, Paul Schulick, Robert Newman, Bharat Aggarwal
Abstract: A pain relieving composition that includes an anesthetic in the range of 0.5%-7.0% by weight (“w/w”), an anti-inflammatory agent in the range of 1.0%-11.0% w/w, a moisturizing agent in the range of 0.5%-12.0% w/w, a humescent in the range of 0.5%-13.0% w/w, a penetration enhancing agent in the range of 0.5%-7.0%, and a carrier solvent in the range of 40.0%-97.0% w/w to be used before and/or after procedures which cause damage to human skin.
Abstract: Described are compositions and agents for blocking serum and other aging factors, especially arNOX in serum, skin or other body fluid or tissue and/or on the cell surface, and methods for using the same. More particularly, the invention relates to agents comprising any one of several naturally-occurring arNOX inhibitors capable of reducing occurrence or severity of or treating disorders and complications of disorders resulting from cell damage caused by aging-related isoforms of NADH oxidase (arNOX). In one exemplary embodiment, nutraceutical, cosmeceutical or pharmaceutical compositions comprise at least one naturally occurring arNOX inhibitor or inhibitor source. Such naturally occurring inhibitors also are capable of augmenting the anti-arNOX effect of other naturally occurring arNOX inhibitory agents.
Type:
Application
Filed:
September 1, 2011
Publication date:
August 16, 2012
Inventors:
D. James Morré, Dorothy M. Morré, Thomas Shelton
Abstract: The present invention relates to a preservative or antimicrobial compositions which comprise low concentrations of botanical extracts, in synergistic combinations with alkanediols in a solvent system, optionally with fruit acids. Additionally, the present invention relates to a preservative or antimicrobial compositions which comprise a silver compound, an essential oil or individual constituent, one or more zinc salts, and one or more alkanediol. The compositions of the invention may be used in personal care products including wound care products or in veterinary use. Preferably, the compositions of the invention have little or no human-detectable fragrance.
Type:
Application
Filed:
December 22, 2011
Publication date:
August 9, 2012
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Shanta M. Modak, Nayana Baiju, Lauserpina A. Caraos, Hari Krishnan Ramachandran
Abstract: Medicaments and therapeutic compositions comprise a composition (1) comprising at least one polyunsaturated fatty acid, at least one pharmaceutically acceptable derivative of a polyunsaturated fatty acid or mixtures thereof and a composition (2) comprising Red Yeast Rice extract comprising about 0.8 wt. % or more monacolin K. One source of component (1) is fish oil. The compositions are useful for lowering cholesterol and/or triglyceride levels in a subject.
Abstract: Medicaments and therapeutic compositions comprise a composition (1) comprising (A) EPA, pharmaceutically acceptable derivatives of EPA or mixtures thereof, and, optionally, (B) DHA, pharmaceutically acceptable derivatives of DHA or mixtures thereof, wherein the weight ratio of A:B is about 7.5:1 or more, and a composition (2) comprising monacolin K, a source of monacolin K or mixtures thereof. One source of component (1) is fish oil. One source of monacolin K is Red Yeast Rice extract. The compositions are useful for lowering cholesterol and/or triglyceride levels in a subject.
Abstract: A herbal composition comprising supercritical fluid extracts/oils of Jyotishmati, Bacopa monnieri, Ginger Oil, Flax Seed oil, Rosemary Ext and Vitamin E is effective in the treatment of symptoms associated with Attention Deficit disorder (ADD) and Attention deficit/hyperactivity disorder (ADHD).
Abstract: An herbal preparation comprised of sage, thyme and cumin is found to relieve the symptoms of inflammation and smooth muscle contraction. The preparation preferably comprises sage, thyme and cumin in the proportions 0.50, 0.43 and 0.07 respectively. The symptoms of menstrual cramps and asthma are relieved by administration of the preparation.
Abstract: Rosemary extracts are used in the treatment of disorders connected to reduced neurotransmission, as well as dietary and pharmaceutical compositions containing these rosemary extracts.
Type:
Application
Filed:
March 29, 2012
Publication date:
July 19, 2012
Applicant:
DSM IP ASSETS B.V.
Inventors:
Antoine De Saizieu, Ann Fowler, Regina Goralczyk, Claus Kilpert, Goede Schueler
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
Type:
Application
Filed:
March 26, 2012
Publication date:
July 19, 2012
Applicant:
METAPROTEOMICS, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
Type:
Application
Filed:
March 26, 2012
Publication date:
July 12, 2012
Applicant:
METAPROTEOMICS, LLC
Inventors:
Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Gary K. Darland, Robert Lerman, Daniel O. Lukaczer, DeAnn J. Liska, Terrence Howell
Abstract: Medicaments and therapeutic compositions comprise (1) a mixture comprising (A) EPA, pharmaceutically acceptable derivatives of EPA or mixtures thereof, and, optionally, (B) DHA, pharmaceutically acceptable derivatives of DHA or mixtures thereof, wherein the weight ratio of A:B is about 7.5:1 or more, and (2) monacolin K, a source of monacolin K or mixtures thereof. One source of component (1) is fish oil. One source of monacolin K is Red Yeast Rice extract. The compositions are useful for lowering cholesterol and/or triglyceride levels in a subject.
Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate dynein expression in the skin. Also provided are methods for screening for substances which modulate dynein expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.
Type:
Application
Filed:
November 29, 2011
Publication date:
July 5, 2012
Applicant:
AVON PRODUCTS, INC.
Inventors:
Qian ZHENG, John W. LYGA, Russell J. WYBORSKI
Abstract: The present invention relates to starch foam microparticles having a porous structure, and which typically have a diameter of less than or equal to about 50 microns. The present invention also relates to novel uses for the starch foam microparticles in beekeeping and in the pharmaceutical, plastics and fragrance industries.
Type:
Application
Filed:
March 15, 2012
Publication date:
July 5, 2012
Applicant:
The United States of America, as represented by the Secretary of Agriculture
Abstract: There are disclosed non-phytotoxic biocompatible compositions comprising tea tree oil (TTO), as well as their use and methods for their production. Other embodiments are also disclosed.
Abstract: A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.
Abstract: Pharmaceutical compositions are for administration to the nasal tract. In particular, dry powder compositions are cellulose, and in particular hydroxypropylmethylcellulose (HPMC), and one or more therapeutic agents. It has been shown that administration of HPMC to the nasal cavity is capable of enhancing natural mucus. These powders, and the gel that forms when they are administered to the nasal tract, have now surprisingly been found to be a very effective way of intranasally administering therapeutic agents, and in particular, herbal or homeopathic agents.
Abstract: The present invention relates to compositions comprising (i) an activator of transport of fatty acids into the mitochondria; (ii) an activator of fatty acid oxidation; and (iii) an inhibitor of fatty acid biosynthesis, and methods for treating insulin resistance, diabetes mellitus type 2, metabolic syndrome, dyslipidemias, obesity, and/or cardiovascular disorders in a subject.
Abstract: According to one embodiment, a coagulant comprising calcium nitrate and an antimicrobial agent is disclosed. The coagulant may be used in the molding process to releasably bond the substrate material to the mold and to bond to the antimicrobial to the substrate material.
Abstract: A composition for increasing the bioavailability of oregano essential oil in humans and animals comprising mixing a first emulsifier and a second emulsifier in a ratio ranging from about 1:1 to about 3:1 with a consumable oil wherein the first emulsifier is polyoxyethylene sorbitan monooleate and the second emulsifier is tocopheryl polyethylene glycol succinate. Adding to that a second mixture of oregano essential oil and the first emulsifier in a ratio of 1:1.
Abstract: The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and/or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC/MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants.
Type:
Application
Filed:
May 14, 2010
Publication date:
May 31, 2012
Applicant:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Inventors:
James E. Simon, Diandian Shen, Hector Rodolfo Juliani, Qingli Wu
Abstract: The present invention is directed to bioactive botanical cosmetic compositions derived from membrane and cell serum fractions of plant cell juice. The present invention also relates to the methods for preparing these bioactive botanical cosmetic compositions and the uses of these compositions in various cosmetic formulations and as topical skin cosmetic applications.
Abstract: The present invention is directed to bioactive botanical cosmetic compositions derived from membrane and cell serum fractions of plant cell juice. The present invention also relates to the methods for preparing these bioactive botanical cosmetic compositions and the uses of these compositions in various cosmetic formulations and as topical skin cosmetic applications.
Abstract: Antimicrobial compositions based on a combination or blend of plant essential oils is of enhanced antimicrobial effectiveness; by adding to the combination of at least two plant essential oils, and preferably adds a small but antimicrobial enhancing effective amount of an enhancer selected from the group consisting of polyionic organic enhancers and polyionic inorganic enhancers. One preferred blended oil composition is a mixture of plant essential oils wherein at least one of the oils is oregano oil. The oil blend is used as a major component in the finished product anti-microbial.
Abstract: Provided herein are essential oils and synthetic compounds, and combinations thereof, as repellent compositions for repelling insects, such as vespid social wasps (Vespidae), including yellowjackets, paper wasps, and hornets. Controlled release devices comprising these repellent compositions are also provided.
Type:
Application
Filed:
August 9, 2011
Publication date:
May 3, 2012
Applicant:
Sterling International Inc.
Inventors:
Rodney G. Schneidmiller, Qing-He Zhang, Doreen R. Hoover
Abstract: A formulation to treat rheumatic disorders and related infections is provided. The formulation is a micro-emulsion including at one or more of an active ingredients. The active ingredient includes one or more of an essential oil mixed with an aqueous phase along with one or more of a surfactant and one or more of a co-surfactant. The co-surfactant is medicated by an extract of one or more of an herb.
Abstract: Antimicrobial compositions based on a combination or blend of plant essential oils is of enhanced antimicrobial effectiveness; by adding to the combination of at least two plant essential oils, and preferably adds a small but antimicrobial enhancing effective amount of an enhancer selected from the group consisting of polyionic organic enhancers and polyionic inorganic enhancers. One preferred blended oil composition is a mixture of plant essential oils wherein at least one of the oils is oregano oil. The oil blend is used as a major component in the finished product anti-microbial.
Abstract: The present disclosure relates to the combined use of two pesticides. A first pesticide composition provides an initial contact kill, and may form a barrier when applied to greasy surfaces. A second pesticide composition provides residual pesticidal activity on the surface. Methods of making and using the pesticide compositions are also provided.
Type:
Application
Filed:
October 12, 2011
Publication date:
April 12, 2012
Applicant:
ECOLAB USA INC.
Inventors:
Victor F. Man, S. John Barcay, Darren M. Jahnke, Yvonne M. Killeen
Abstract: Methods for killing insects and a nest are disclosed. The methods may be used to disrupt a colony of nestdwelling insects. The insects may include wasps, hornets, and yellowjackets.
Type:
Application
Filed:
September 30, 2011
Publication date:
April 12, 2012
Applicant:
STERLING INTERNATIONAL INC.
Inventors:
Rodney G. Schneidmiller, Qing-He Zhang, Guiji Zhou, Doreen R. Hoover
Abstract: Disclosed herein are compositions and methods for the treatment and management of pain in a subject, comprising topically or orally administering a therapeutically effective amount of a composition comprising herbal extracts and compound mixtures to a subject.
Abstract: Disinfecting compositions having tuberculocidal and fungicidal efficacies for disinfecting and sanitizing inanimate surfaces is provided. The disinfecting compositions contain thyme oil or thyme oil and origanum oil, a salt of a transition metal, a biobased surfactant and water. This improved disinfecting composition is botanical, environmentally sustainable, non-toxic, mildly scented and highly stable.
Abstract: A topical drug delivery system for use as a self-medication delivery system, formed as a multi-functional hygroscopic solution comprising a non-hygroscopic first chemical penetration enhancer, a hygroscopic second chemical penetration enhancer and an anti-oxidizing dispersant mixable in solution with the first and second chemical penetration enhancers and an active pharmaceutical ingredient, said dispersant being in a weight percent of the solution of between 3% and 10% and being suitable for providing multiple secondary therapeutic effects by interaction with the active pharmaceutical ingredient to ensure substantial homogenous distribution of the selected active pharmaceutical ingredient in the solution during delivery of the solution to all areas of the mammalian tissue location and by further reducing the water activity level of the solution.
Abstract: The present invention generally relates to a wet wipe or sheet that is suitable for contacting the skin and removing mucus from the skin. More specifically, the present invention relates to a wet wipe having an aqueous saline component suitable for dissolving and removing mucus in combination with the fabric matrix of the wet wipe. Typically, the fabric matrix of the wet wipe has a capacity of about 125 grams of solution per square meter, and it is impregnated with the aqueous saline solution to a level at or below approximately 80% of the absorbent capacity of the matrix.
Abstract: The invention relates to a cosmetic composition comprising at least one extract from the orchid Dendrobium chrysotoxum as an active agent and at least one cosmetically acceptable excipient. The invention relates to the use in a cosmetic composition of an extract from the orchid Dendrobium chrysotoxum as an active agent for preventing or delaying the appearance of the signs of skin ageing or for slowing or attenuating the effects thereof, or else also for promoting cell or tissue longevity. The invention in particular relates to an orchid extract inhibiting the expression and/or the activity of the mitochondrial protein Smac/DIABLO.
Abstract: Antimicrobial compositions based on a combination or blend of plant essential oils is of enhanced antimicrobial effectiveness; by adding to the combination of at least two plant essential oils, and preferably adds a small but antimicrobial enhancing effective amount of an enhancer selected from the group consisting of polyionic organic enhancers and polyionic inorganic enhancers. One preferred blended oil composition is a mixture of plant essential oils wherein at least one of the oils is oregano oil. The oil blend is used as a major component in the finished product anti-microbial.
Abstract: The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachadonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
Type:
Grant
Filed:
June 29, 2010
Date of Patent:
February 14, 2012
Assignees:
New Chapter Inc., Board Of Regents Of The University Of Texas System
Inventors:
Thomas Newmark, Paul Schulick, Robert Newman, Bharat Aggarwal
Abstract: Disclosed herein is a herbal composition comprising supercritical fluid extracts/oils of Jyotishmati, Bacopa monnieri, Ginger Oil, Flax Seed oil, Rosemary Ext and Vitamin E in an effective amounts useful in the treatment of symptoms associated with Attention Deficit disorder (ADD) and Attention deficit/hyperactivity disorder (ADHD).
Abstract: A composition of matter comprises a shelf stable, super critical, CO2 fluid extracted seed oil derived from a cracked biomass of perilla frutescens, the seed oil comprising from about 60 to about 95 percent w/w of PUFAs in a ratio of from about 4:1 to about 6:1 alpha-linolenic acid (ALA) to linoleic acid (LA) and a mixture of selected antioxidants.
Type:
Application
Filed:
September 13, 2011
Publication date:
February 2, 2012
Applicant:
U.S. Nutraceuticals, LLC d/b/a Valensa International
Inventors:
John A. Minatelli, W. Stephen Hill, Rudi E. Moerck, Uy Nguyen
Abstract: The present invention provides a method of toning the face comprising the steps of (a) dissolving in water a toner concentrate in the form of a solid comprising (i) citric acid; (ii) sodium bicarbonate; (iii) one or more essential oils; to provide a toner, and (b) applying the toner to the face.
Type:
Application
Filed:
June 2, 2009
Publication date:
January 26, 2012
Inventors:
Mark Constantine, Margaret Joan Constantine, Helen Elizabeth Ambrosen
Abstract: A natural color is concentrated to intensify color range and to provide useful amounts of one or more of anti-oxidant, nutritional, and anti-inflammatory compounds derived from one or more pigment sources. In a preferred embodiment, the pigment source is a fruit, a vegetable, a legume, a spice, algae, or a combination thereof.
Type:
Application
Filed:
July 13, 2011
Publication date:
January 19, 2012
Inventors:
Paul Altaffer, Jeffrey M. Wuagneux, Pi-Yu Hsu
Abstract: Provided is a composition for preventing or treating insomnia. The composition includes, as an active ingredient, extract of Phlomis umbrosa Turcz. or a combination thereof with extract of Polygala tenuifolia Willd. Particularly, the combination of extract of Phlomis umbrosa Turcz. with extract of Polygala tenuifolia Willd. enables recovery of the sleep of patients suffering from insomnia nearly to that of normal persons. The composition for treating insomnia uses active ingredients that have been used as Chinese traditional medicines, and thus is safe to the human body.
Abstract: Combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication are provided. The vasoactive compounds are esculoside, visnadine, forskolin or extracts thereof, purified lipophilic extracts from plants of the genus Ipomea, esters of ximenynic acid, icarin or icarin derivatives, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.
Abstract: The invention comprises a composition for the reduction of snoring, a packaging therefor and a method for the manufacture thereof. The composition can be applied in the pharynx in different variants, in particular as spray, as gel or as foam formulation. Application of the composition at least temporarily reduces the snoring of a treated person. The invention further comprises the use of marrubiin for the manufacture of a medication for the treatment of snoring.
Type:
Application
Filed:
August 25, 2011
Publication date:
December 15, 2011
Applicant:
PURANOX MEDICAL B.V.
Inventors:
Hans Marcel Brand, Annelize Frieda Goedbloed
Abstract: The present invention relates to dermal patches comprising natural polysaccharides without the need for any pressure sensitive synthetic polymers. Particularly, the present invention relates to patches comprising a bioadhesive composition comprising a polysaccharide exudate and an essential oil useful for transdermal delivery of therapeutic or cosmetic agents.
Abstract: Methods, compositions, and strategies for the treatment of malignant neoplasms are presented herein. The treatment modalities are directed towards exploiting characteristics of cancer cells as well as correcting defective biochemical pathways and systems in the body.