Abstract: A method for treating a subject suffering from refractory rheumatoid arthritis includes the step of administering an effective amount of a quinonemethide triterpenoid or a pharmaceutically tolerable salt, solvate or anhydrate thereof to the subject. Also is a method for inducing autophagy in a synovial fibroblast, and a method of inducing calcium mobilization in a synovial fibroblast. Further a pharmaceutical composition includes an effective dose of a quinonemethide triterpenoid and an anti-arthritis compound. The quinonemethide triterpenoid is suitable to treat refractory rheumatoid arthritis (RA) in particular ABC-protein-dependent RA and apoptosis-deficient RA. The quinonemethide triterpenoid also possesses significant inhibitory effects on the growth of synovial fibroblasts, in particular modulating the calcium homeostasis in multidrug-resistant rheumatoid arthritis synovial fibroblasts.
Type:
Grant
Filed:
July 10, 2017
Date of Patent:
June 23, 2020
Assignee:
MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A method and composition for reducing the recovery time for a human suffering from mild traumatic brain injury are provided. The composition is a mixture of component supplements that synergistically address the symptoms of the condition and the damage done by the injury.
Abstract: Products derived from the Tripterygium wilfordii Hook F (TwHF) plant in the form of extracts are provided that are useful in preventing, treating, or ameliorating a symptom of an inflammatory disorder or an immune disorder, such as an auto-immune disease. Also provided are methods of freeze-drying a TwHF root and/or root portion, methods of debarking a freeze-dried TwHF root and/or root portion, methods of preparing and/or refining extracts in freely flowable solid form from freeze-dried debarked TwHF roots and/or root portions, and methods of using freely flowable solid extracts of TwHF in preventing, treating or ameliorating a symptom of an inflammatory disorder and/or an immune disorder.
Type:
Application
Filed:
March 1, 2012
Publication date:
February 27, 2014
Inventors:
George Paffendorf, Christopher M. Cimarusti
Abstract: A pharmaceutical composition for the treatment of rheumatism and a method of preparing it are provided. The composition consists of an alcoholic extract of 1-4 parts by weight Tripterygium hypoglaucum (Levl.) Hutch.; 1-4 parts by weight Epimedium brevicornum Maxim.; 1-4 parts by weight Lycium barbarum L.; and 1-4 parts by weight Cuscuta chinensis Lam., or Cuscuta australis R. Br. The composition has substantial therapeutic efficacy, with mild side effects, and is easy to administer.
Abstract: A topical herbal formulation for preventing and/or treating dyshidrosis (pompholyx), non-responsive to topical steroids. The formulation may also be used to treat contact dermatitis, eczema, palmoplantar pustulosis and skin infections incurred by invasive pathogens such as mold, fungus and bacteria. The formulation is comprised of plant extracts and niacin, that when combined yield an effective multi-faceted pharmaceutical approach to treating dry skin disorders. The active ingredients within the formula include a combination of dry, aqueous, acid and alcohol extracts of black walnut hull (Juglans Nigra), wormwood (Artemisia Absinthium), tumeric rhizome (Curcuma Longa), garlic (Allium sativum), chamomile (Matricaria Chamomile), licorice root (Glycyrrhiza Glabra), St Johns wort (Hypericum perforatum), aloe vera, niacin and herbal anti-bacterial agents.
Abstract: This invention relates to a use of a fermented Glycine max (L.) extract prepared by fermenting an aqueous Glycine max (L.) extract with at least one lactic acid bacteria together with at least one yeast, in enhancing Natural Killer (NK) cell activity. In particular, the fermented Glycine max (L.) extract can be used in preventing and/or treating a disease in which NK cell activation is implicated in a subject, such as cancer, infectious diseases and modulating the immune system.
Abstract: The invention relates to disclose some Chinese formula for psoriasis. Whether treatment for psoriasis is targeted at both the hyperproliferative and inflammatory aspect of the topical therapy. Specially, the administration dosage is soft gel, cream, tincture and aerosol etc. topical dosages.
Abstract: A novel therapeutic composition comprises three novel herbal extracts: Herba epimedium Extract, Rhizoma Drynaria fortunei (kze.) J. Sm Extract and Radix Tripterygium hypoglaucum (L'evl.) Hutch Extract, which are prepared through standardized manufacturing processes, respectively. A new formulation AHT-323 contains these three herbal extracts. The novel therapeutic composition described in the present application can be used for treating autoimmune diseases such as rheumatoid arthritis, inflammatory disorders and pain.
Abstract: The present invention relates to the use of polyamide particles as anti-irritant agents for reducing or eliminating the irritant effect of one or more compounds with an irritant effect, preferably in a cosmetic or dermatological composition.
Abstract: The present invention provides compositions comprising the ingredients of plants of species of the genera Stephania, Coix, Pinellia, Prunus, Phellodendron, Sophora, Tetrapanax, Stemona, Glycyrrhiza, Tripterygium, Forsythia and Siegesbeckia, wherein such compositions have analgesic, antipyretic, and antiinflammatory properties. The present invention also provides methods of using such compositions for treating various conditions and diseases, including joint swelling, joint pain, osteoarthritis and rheumatoid arthritis.