Containing Or Obtained From A Root, Bulb, Tuber, Corm, Or Rhizome (aka Radix) Patents (Class 424/773)
  • Patent number: 10517844
    Abstract: In various embodiments a cancer treatment method is provided based on inhibition of proline catabolism. When combined with p53 restoration therapy and/or inhibition of glutaminase, the inhibition of proline catabolism results in a “synthetic lethal” and synergistic anticancer response. Novel suicide inhibitors that induce the degradation of proline dehydrogenase (PRODH) are also provided. Also provided is a method of assaying PRODH to identify responders/non-responders to inhibition of proline catabolism and/or glutaminase.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: December 31, 2019
    Assignee: Buck Institute for Research on Aging
    Inventors: Gary K. Scott, Christopher C. Benz
  • Patent number: 10472323
    Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 12, 2019
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Xinyong Lv, Guowei Song, Dongdong Wu, Daiqiang Hu, Jun Gu, Gang Chen, Xiang Ji, Xiuchun Zhang, Jinchao Ai, Xianqi Kong
  • Patent number: 10398747
    Abstract: Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb extract of a mixture of 3.5:1 Dioscorea Rhizoma:Dioscorea nipponica (w/w). Having the ability to synergistically increase in vivo levels of nerve growth factor, compared to the extracts from the herbs alone or her mixtures of other weight ratios, the mixed herb extract is effective for preventing the apoptosis of nerve cells and promoting nerve regeneration. Thus, it can be applied to pharmaceutical compositions and health function foods preventive and curative of diabetic peripheral neuropathy.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: September 3, 2019
    Assignee: Dong-A St Co., Ltd.
    Inventors: Soon-Hoe Kim, Mi-Won Son, Sang-Zin Choi, Hye-Ju Kim, Ja-Young Ryu, Sun-Yeou Kim
  • Patent number: 10016387
    Abstract: Method for treating melanoma is provided.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 10, 2018
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, Jui-Ying Cho
  • Patent number: 9987323
    Abstract: The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coated formulation of extract of Ashwagandha to humans. The enteric coating protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 5, 2018
    Inventor: Benny Antony
  • Patent number: 9907878
    Abstract: The present invention relates to a wet tissue containing a hot water extract of Coptidis Rhizoma extracted under high temperature and high pressure conditions, or a distillate thereof, and more specifically, to a wet tissue containing a hot water extract of Coptidis Rhizoma obtained by mixing 2,000-8,000 parts by weight of water on the basis of 100 parts by weight of Coptidis Rhizoma and extracting the same under high temperature and high pressure conditions of 120-131° C. and 1.2-2.8 atm, respectively, or a distillate thereof. The wet tissue containing a hot water extract of Coptidis Rhizoma or a distillate thereof shows remarkable antibacterial and fungicidal activities against pathogenic microorganisms existing in the skin and has an excellent inflammation inhibitory effect, and thus can be readily used for cleaning the skin and alleviating various inflammatory diseases.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: March 6, 2018
    Inventors: Yea Sung Lee, Yeon Ju Yu
  • Patent number: 9872840
    Abstract: The present invention relates to the use of garcinol as a nephroprotective agent. The present invention also relates to the use of garcinol as a therapeutic agent in renal disorders, in particular diabetic nephropathy, and to medicinal preparations containing garcinol. Further disclosed herein are method of treatment of renal disorders, in particular diabetic nephropathy by administration of garcinol.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: January 23, 2018
    Assignee: Delhi Institute of Pharmaceutical Sciences and Research
    Inventors: Sonia Gandhi, B. P. Srinivasan
  • Patent number: 9833487
    Abstract: In some embodiments, a composition for the treatment and inhibition or prevention of arthritic diseases includes an extract of mixed herbs, the mixed herbs including an active ingredient with Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: December 5, 2017
    Assignee: University-Industry Cooperation Group of Kyung Hee University
    Inventors: Dong-Suk Park, Myung Chul Yoo, Do-Young Choi, Hyung In Yang, Yong-Hyeon Baek, Jeong-Eun Huh, Kyoung Soo Kim, Yong-Baik Cho, In Ho Jung, Jong Hyun Hur, Jae Dong Lee
  • Patent number: 9795649
    Abstract: The present invention relates to a novel use of sesquiterpenoid compounds, the pharmaceutically acceptable salts thereof, or the extracts of Cyperus rotundus comprising same or the fractions thereof in the prevention or treatment of menopausal diseases. The sesquiterpenoid compound according to the present invention, the extracts of Cyperus rotundus comprising the same or fractions thereof exhibit excellent estrogenic activity or anti-allergic activity, and therefore they can be used for the prevention or treatment of menopausal diseases caused by a decline in estrogen level or by allergic diseases.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: October 24, 2017
    Assignee: Research & Business Foundation Sungkyunkwan University
    Inventors: Kyu Hyuck Chung, Jong Hwan Kwak
  • Patent number: 9750682
    Abstract: A method for stimulating collagen synthesis in aging skin cells in need of treatment by stimulating SIRT1, SIRT3, and SIRT6 and a method for preparing a topical composition for stimulating SIRT1, SIRT3, and SIRT6 in skin cells.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 5, 2017
    Assignee: ELC Management, LLC
    Inventors: Nadine Pernodet, Donald Collins
  • Patent number: 9724326
    Abstract: The present invention relates to a composition for use in the treatment of an intestinal tract disorder caused by a gluten-associated protein, said composition comprising at least one agent which binds to the gluten-associated protein, characterized in that the composition is administered at the same time as or at most within 60 minutes after administration of at least one tannin to a patient.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: August 8, 2017
    Assignee: STADA Arzneimittel AG
    Inventor: Albert Missbichler
  • Patent number: 9668960
    Abstract: The invention relates to methods useful in studying or modulating skin or hair pigmentation and to the use of plant extracts in compositions as well as to methods comprising the topical use of such compositions to reduce or to enhance skin or hair pigmentation.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: June 6, 2017
    Assignee: L V M H RECHERCHE
    Inventors: Robin Kurfurst, Carine Nizard, Sylvianne Schnebert, Eric Perrier, Desmond J. Tobin, Suman K. Singh
  • Patent number: 9561244
    Abstract: A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating Na+K+ATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: February 7, 2017
    Assignee: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventor: Linda Saxe Einbond
  • Patent number: 9486525
    Abstract: The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: November 8, 2016
    Assignee: The Research Foundation of the City University of New York
    Inventors: Linda Saxe Einbond, I. Bernard Weinstein
  • Patent number: 9485953
    Abstract: A method of modifying the content of certain chemical compounds in tobacco materials is provided, the method including treatment of a tobacco plant or portion thereof with at least one enzyme. For example, the method may modify the content of tobacco smoke toxicant precursors in tobacco materials, which can result in a modification in toxicant production when the tobacco material is exposed to elevated temperatures. The type of tobacco plant or portion thereof treated according to the invention can be, for example, a tobacco seed, a tobacco seedling, an immature live plant, a mature live plant, a harvested plant, or a plant derivative. Smoking articles and other tobacco products including such enzyme-treated tobacco materials are also provided.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: November 8, 2016
    Assignee: R.J. Reynolds Tobacco Company
    Inventors: Serban C. Moldoveanu, Jerry Wayne Marshall, Marvin Glenn Riddick, Michael F. Davis
  • Patent number: 9248124
    Abstract: The present invention provides inhibitors of I?B kinase of general formula (I). or a stereoisomer or physiologically tolerable salt thereof, for use in the inhibition of the growth of a multiple myeloma cell and for use in the treatment of multiple myeloma, wherein R1-R8 and B6-B9 are described in the specification.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: February 2, 2016
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Kenneth C. Anderson
  • Patent number: 9115106
    Abstract: The present invention refers to the use of HMP (a secondary metabolite obtained from Aspergillus fungi) as an agent that intensifies the mechanism of macrophage activation, leading to the death of L. (Leishmania) amazonensis, the etiologic agent of cutaneous leishmaniasis. The main mechanism of action of this agent is the activation of the microbicidal activity of host cells, through increased superoxide production, number of lysosomes, actin and microtubule filament polymerization and increased spreading, typical of activated cells. Additionally, HMP represents a molecule of easy acquisition, presents an efficient combat mechanism with no adverse reactions and capacity to inhibit the development of promastigotes and amastigotes forms. Finally, results suggest HMP to be a potential candidate for use against cutaneous leishmaniasis at a minimal concentration of 50 ?g/mL.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: August 25, 2015
    Assignee: UNIVERSIDADE FEDERAL DO PARA
    Inventors: Alberdan Silva Santos, Edilene Oliveira da Silva, Jose Luiz Martins do Nascimento, Claudio Naum Alves, Ana Paula Drumond Rodrigues, Antonio Sergio da Costa Carvalho
  • Patent number: 9056049
    Abstract: The present invention relates to a micro-particle for extending satiety and controlling blood glucose and lipid levels, comprising a core having the protein extract from sweet potato, an active ingredient layer coated on the core, and a protection layer coated over the active ingredient layer as an external layer, wherein the protein extract from sweet potato contains trypsin inhibitor and glycoprotein. The micro-particle comprising a protein extract from sweet potato can effectively extend satiety, control blood glucose and lipid levels and increase metabolism effectively.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: June 16, 2015
    Inventor: Chin Yuan Huang
  • Publication number: 20150132421
    Abstract: The present invention describes the obtaining process of the dichloromethane fraction and subfractions from Eleutherine plicata, popularly known as “marupazinho, marupari, palmeirinha, coquinho, marupaí, marupaú, marupá-piranga, and lirio-folha-de-palmeira”. This invention comprises the obtaining process of pharmaceutical compositions that contain the dichloromethane fraction and/or naphthoquinone, as well as its use for malaria treatment. Extract and fractions were assayed and presented antiplasmodial activity, particularly against chloroquine-resistant Plasmodium falciparum (clone W2).
    Type: Application
    Filed: May 13, 2013
    Publication date: May 14, 2015
    Inventors: Maria Fani Dolabela, Michel T. Martins, Dayse Lucia do Nascimento Brandao, Edinilza da Silva Borges, Sandro Percario, Andrey Moacir do R. Marinho, Thiago L. da Silva, Thyago da Costa Vilhena, Flavio de Vasconcelos, Eduardo F. Mota, Adriana Veiga da Conceicao Silva, Alaide Braga de Oliveira, Geraldo Celio Brandao, Renata Cristina de Paula, Maria Fernanda Alves do Nascimento, Marinete Marins Povoa, Marlia Regina Coelho-Ferreira, Damaris Busman
  • Publication number: 20150132415
    Abstract: The present invention provides a pharmaceutical composition or a cosmetic product which can accelerate production of ceramide in cells. The ceramide production-accelerating agent contains a plant selected from the group consisting of Radix Heraclei Scabridi, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Pseudobulbus Bletillae, Radix Polygoni Multiflori, Radix Platycodi, and Herba Leonuli, or an extract thereof as an active ingredient. Further, the present invention provides a moisturizing agent containing a plant selected from the group consisting of Herba Leonuri and Rhizoma Dioscoreae, or an extract thereof as an active ingredient.
    Type: Application
    Filed: January 20, 2015
    Publication date: May 14, 2015
    Applicants: Zhongshan Hospital of Fudan University, Kao Corporation
    Inventors: Wan Zhang QIN, Chun Xin Yang, Fan Qi Kong, Hiroshi Nojiri, Shotaro Ito
  • Publication number: 20150110758
    Abstract: A treatment protocol for use in the treatment of neurocutaneous syndrome is described and comprises at least one xanthone component, which may comprise at least one mangosteen component, and at least one detoxification component. Additional embodiments comprise at least one herbal component, at least one vitamin component, or a combination thereof. A method of treating a patient having neurocutaneous syndrome is described herein and comprises: providing at least one xanthone component, which may comprise at least one mangosteen component, providing at least one xanthone component, which may comprise at least one mangosteen component, to the patient, and administering the at least one detoxification component to the patient. Additional methods steps may include providing and administering at least one herbal component, providing and administering at least one vitamin component or a combination thereof.
    Type: Application
    Filed: January 5, 2015
    Publication date: April 23, 2015
    Inventor: Omar M. Amin
  • Publication number: 20150093461
    Abstract: The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 2, 2015
    Inventors: JING CHENG, CHIA-WEN CHEN, STEVEN FRANCIS SCHNITTGER, MING LU
  • Patent number: 8993013
    Abstract: A composition for enhanced bioavailability of curcumin including purified curcuminoid and purified essential oil of turmeric. A method to prepare a composition for enhanced bioavailability of curcumin having purified curcuminoid and purified essential oil of turmeric.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: March 31, 2015
    Assignee: Arjuna Natural Extracts, Ltd.
    Inventor: Benny Antony
  • Publication number: 20150086661
    Abstract: A cosmetic active ingredient obtained from roots of Paeonia albiflora, which is a hydrolyzate of roots of Paeonia albiflora including at least 30% of carbohydrates by weight relative to the total weight of dry materials. The cosmetic active ingredient can be used in a composition and in a cosmetic care process for care of the human skin.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 26, 2015
    Applicant: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE
    Inventor: Jean PAUFIQUE
  • Publication number: 20150079207
    Abstract: A method for preparing a Smilax china L. root extract having an increased active ingredient content, and a beverage composition for detoxification including the same are provided. The method for preparing a Smilax china L. root extract includes preparing a powder of a Smilax china L. root, obtaining an ethanol extract of Smilax china L. root from the powder of Smilax china L. root using ethanol, and concentrating the ethanol extract of Smilax china L. root under a reduced vacuum to obtain a concentrate having a reduced ethanol content.
    Type: Application
    Filed: June 16, 2014
    Publication date: March 19, 2015
    Inventors: Soon Mi SHIM, Tae Sik PARK, Jae Hwan CHUNG, Kyung Moo KIM, So Ra YOON, Ui Jeong YANG, Yu Ra SON, Joo Won SUH, Seung Hwan YANG
  • Publication number: 20150079128
    Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).
    Type: Application
    Filed: September 18, 2013
    Publication date: March 19, 2015
    Applicant: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 8980344
    Abstract: The present invention provides a skin care product comprising at least two enhancers and at least one skin care ingredient, wherein the at least two enhancers are selected from cyclodextrin, pentasodium pentetate, phytic acid, potassium citrate, sodium citrate, potassium gluconate and sodium gluconate.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: March 17, 2015
    Inventor: Dennis F. Gross
  • Publication number: 20150050371
    Abstract: The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.
    Type: Application
    Filed: March 9, 2012
    Publication date: February 19, 2015
    Applicant: BIOTROPICS MALAYSIA BERHAD
    Inventors: Matthias Gehling, Bärbel Köpcke, Thomas Küper, Kathrin Reinhardt, Peter Reinemer, Annie George, Sasikala Chinnappan, Mazria Haslina Md Akir
  • Publication number: 20150044315
    Abstract: The present invention relates to a plant extract from a low-tetrahydrocannabinol (THC) variety of Cannabis sativa subsp. sativa for the treatment of disease.
    Type: Application
    Filed: October 27, 2014
    Publication date: February 12, 2015
    Inventors: Regina Klaeger, Rudolph Klaeger
  • Publication number: 20150044306
    Abstract: A process for fractionating a plant material to provide isolated extractives, the process includes pretreating the plant material to provide a fluidized plant material, subjecting the pretreated fluidized plant material to high frequency pulses and shear forces without denaturing bioactive aspects of one or more components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, separating the first liquid fraction having extractives from the first fractionated plant material, and isolating extractives from the first liquid fraction.
    Type: Application
    Filed: August 8, 2014
    Publication date: February 12, 2015
    Inventors: Melvin Mitchell, James Etson Brandenburg, JR.
  • Publication number: 20140369995
    Abstract: The present invention provides compositions and methods for treating stroke patients using TCM and a Western medicament used for the treatment of stroke patients.
    Type: Application
    Filed: September 3, 2014
    Publication date: December 18, 2014
    Inventors: David Picard, Shi Xue Min, Michael Lazdunski
  • Publication number: 20140370135
    Abstract: The invention provides methods for treating and/or preventing the recurrence of a senile cataract, and/or for inhibiting the development of a senile cataract and/or an incipient senile cataract, in a human or animal subject. The invention further provides nutraceutical compositions suited for the same, derived from an extract of the plant Capraria biflora. The compositions comprise the extract in a therapeutically sufficient amount for the treatment and/or prophylaxis of a senile cataract in a human and/or animal subject.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Applicant: BURROWS ENTERPRISES, LLC
    Inventor: Adria BURROWS
  • Patent number: 8906433
    Abstract: The present invention relates to a skin moisturizing cosmetic composition that includes a pine resin extract, a Pinus Densiflora needle extract, and a Pinus Densiflora root extract, as active ingredients. More specifically, the present invention includes a pine resin extract, a Pinus Densiflora needle extract, and a Pinus Densiflora root extract, as active ingredients, and has advantageous effects of improving moisturizing activity on the skin and enhancing skin texture, skin clearness and skin contour.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: December 9, 2014
    Assignee: Amorepacific Corporation
    Inventors: Jeong Cheol Ha, Lee Kyoung Kwon, Youn Joon Kim, Ho Sik Rho, Sang Hoon Han
  • Patent number: 8906423
    Abstract: The present invention concerns a phytotherapic compound for the treatment of herpes based on Uncaria tomentosa characterized by the presence of: (a) A therapeutically efficient amount of an Herbal Extract from Uncaria tomentosa (Willd) DC Rubiaceae, (b) a pharmaceutically acceptable vehicle, (c) at least one pharmaceutically acceptable excipient, and, (d) optionally, pharmaceutically acceptable adjuvants. It also concerns a process of extraction for obtaining the Herbal Extract from Uncaria tomentosa (Willd) DC Rubiaceae, active ingredient of the phytotherapic compound for the treatment of herpes of the present invention.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: December 9, 2014
    Assignee: Herbarium Laboratorio Botanico Ltda.
    Inventor: Anny Margaly Maciel Trentini
  • Publication number: 20140341921
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: November 29, 2012
    Publication date: November 20, 2014
    Applicants: The University of Tokyo, School Corporation , Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20140342010
    Abstract: The present invention provides a method of using Polygonum multiflorum or extracts thereof to enhance stem cell mobilization in a subject, including hematopoietic stem cells (HSCs) and bone marrow stem cells (BM-SCs). In one embodiment, a blended composition of plant parts, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote mobilization of stem cells, resulting in migration of the stem cells to specific sties of maintenance and repair within tissues and/or organs. Increased circulation of HSCs and/or BMSCs and migration towards sites of maintenance promotes the natural regeneration mechanisms in the body.
    Type: Application
    Filed: November 15, 2012
    Publication date: November 20, 2014
    Applicant: Stemtech International, Inc.
    Inventors: Christian Drapeau, Gitte S. Jensen
  • Publication number: 20140335209
    Abstract: There is provided a process for making a composition suitable for topical application comprising the steps of a) heating at least one fruit and/or vegetable pulp to up to a temperature in the range of about 40° C. to 100° C.; b) mixing between 1 and 40% w/w of a mild base with the heated fruit and/or vegetable pulp. There is also provided a fruit and/or vegetable derived composition suitable for topical application prepared by the above process. There is further provided a fruit and/or vegetable derived composition comprising at least one fruit and/or vegetable-derived pulp and a mild base, said composition having a pH in the range of about 7.5 to about 9.5.
    Type: Application
    Filed: February 12, 2014
    Publication date: November 13, 2014
    Inventor: Thomas James MCARTHUR
  • Patent number: 8871282
    Abstract: A composition for suppressing cough, removing sputum, preventing and/or treating a respiratory disease comprising an extract of Coptidis rhizoma or a combined extract of Coptidis rhizoma with ivy leaf as an active ingredient, and a method of suppressing cough, removing sputum, and/or preventing and/or treating respiratory disease using the composition, are provided.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: October 28, 2014
    Assignee: Ahn-Gook Pharmaceutical Co., Ltd.
    Inventors: Jin Auh, Chang-Hwan Kim, Chang-Kyun Han, Sung-Hum Yeon, Young-June Shin, Min-Ki Shin, Soo-Im Chang
  • Patent number: 8871280
    Abstract: Compositions for treating fungal activity in plants, containing castor oil, water, at least one surface active agent, optionally pennyroyal oil, and optionally an agriculturally acceptable carrier. Methods of treating fungal activity in plants, involving administering to the plant or soil an effective fungal treating amount of castor oil, water, at least one surface active agent, optionally pennyroyal oil, and optionally an agriculturally acceptable carrier.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: October 28, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Dilip K. Lakshman, Kamlesh R. Chauhan
  • Patent number: 8859006
    Abstract: A Semen Cassiae soft capsule for lowering blood lipids and losing weight and the preparation method thereof. The content of the soft capsule consist of the following components by weight part: 10-60 parts of ethanol soluble extract powder of Semen Cassiae, 2-10 parts of aqueous soluble extract powder of Radix Glycyrrhizae, 10-30 parts of evening primrose oil, 5-20 parts of sea buckthorn seed oil and 2-10 parts of beeswax.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: October 14, 2014
    Inventor: Jianzhong Ma
  • Patent number: 8859020
    Abstract: Disclosure provides a formulation of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin and to augment the biological activity of curcumin, wherein curcumin is the main constituent of curcuminoid and wherein Ar-turmerone is the main constituent of the essential oil of turmeric. An application of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin for oral supplementation against a variety of diseases and method of doing the same is provided.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: October 14, 2014
    Inventor: Benny Antony
  • Patent number: 8815220
    Abstract: Sunscreen compositions containing an extract of Curcuma longa L. are provided, the sunscreens having an absorption that spans the UVA and UVB ranges in a manner that meets updated FDA recommendations without requiring the addition of titanium dioxide. The sunscreens can also include an extraction solvent that is at least substantially non-toxic and useful also as a pharmaceutically acceptable carrier in liquid dosage forms. Microemulsions and nanoemulsions are also provided to enhance the bioavailability and stability of the extracts in the sunscreens.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 26, 2014
    Assignee: California Northstate College of Pharmacy, LLC
    Inventors: Indiran Pather, Tibebe Zewdie Woldemariam
  • Patent number: 8802161
    Abstract: The invention describes a nutraceutical composition and method for preventing/treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2?,3,4?5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: January 30, 2010
    Date of Patent: August 12, 2014
    Assignee: Florida Agricultural and Mechanical University
    Inventors: Elizabeth Anne Mazzio, Karam F Soliman
  • Patent number: 8790727
    Abstract: Embodiments of the invention relate to fortified food and dietary supplement products which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with Morinda citrifolia and iridoids.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: July 29, 2014
    Assignee: Tahitian Noni International, Inc.
    Inventors: Brett Justin West, Claude Jarakae Jensen, Afa Kehaati Palu, Shixin Deng, Jeffrey A. Wasden
  • Publication number: 20140186331
    Abstract: The present invention provides a body weight gain suppressing composition including an ?-glucosidase activity inhibitor component, preferably a component derived from at least one plant selected from the group consisting of Salacia genus plants, touchi and mulberry, and a lipid synthesis inhibitor component, preferably, at least one selected from the group consisting of soybean peptide, marine animal peptide, and sesame lignin, and also provides a food product including the composition.
    Type: Application
    Filed: February 20, 2014
    Publication date: July 3, 2014
    Applicant: FUJIFILM Corporation
    Inventors: Yuriko ODA, Fumitaka Ueda
  • Patent number: 8765192
    Abstract: A method of topically applying natural plant product for dissipation of human adipose tissue, comprising: (a) topically applying an inner portion of a natural plant product to an epidermal layer exterior to adipose tissue to be dissipated of a user's body for a period of time, upon which a percentage of the adipose tissue softens and dissolves, thus, reducing the adipose tissue of the user's body; (b) removing the topically applied inner portion of the natural plant product from the epidermal layer for another period of time; (c) repeating steps (a) and (b); and weight reduction apparatus comprising a topical applicator having a receiving container adapted to removably receive a natural plant product and having an opening or a porous wall adapted to facilitate pulp, juices, and/or extracts of the natural plant product to contact a user's epidermal layer exterior to the adipose tissue to be dissipated.
    Type: Grant
    Filed: November 20, 2010
    Date of Patent: July 1, 2014
    Inventor: Joseph Lichtenstein
  • Patent number: 8765197
    Abstract: The present invention relates to herbal extracts of Sinapis Semen, Corydalis Tuber, Pharbitidis Seed, and Strychni Ignatii Semen, and a composition containing the same for treating and preventing gastrointestinal motility disorder. The extracts of the present invention have a remarkable effect of promoting gastrointestinal motility through HT3 receptor antagonism and/or HT4 receptor antagonism.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: July 1, 2014
    Assignee: Dong-A-Pharm, Co., Ltd.
    Inventors: Mi Won Son, Sang Jin Choi, Chong Hwan Cho, Nam Joon Baek, Tae Ho Lee, Jae Keol Rhee, Soon Hoe Kim, Moo Hi Yoo, Mi Rim Jin, Jin Pub Son
  • Patent number: 8765196
    Abstract: Disclosed is a method for separating and purifying Ginkgolide C from root bark of ginkgo.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: July 1, 2014
    Assignee: Guizhou University
    Inventors: Jun He, Jichuan Kang, Jianian Yang, Yixin Qian
  • Publication number: 20140178316
    Abstract: The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.
    Type: Application
    Filed: June 5, 2012
    Publication date: June 26, 2014
    Applicant: US COSMECEUTECHS, LLC
    Inventors: Joseph Abernathy Lewis, II, Joseph C. DiNardo
  • Patent number: RE45524
    Abstract: A composition for suppressing cough, removing sputum, preventing and/or treating a respiratory disease comprising an extract of Coptidis rhizoma or a combined extract of Coptidis rhizoma with ivy leaf as an active ingredient, and a method of suppressing cough, removing sputum, and/or preventing and/or treating respiratory disease using the composition, are provided.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: May 19, 2015
    Assignee: AHNGOOK PHARMACEUTICAL CO., LTD.
    Inventors: Jin Auh, Chang-Hwan Kim, Chang-Kyun Han, Sung-Hum Yeon, Young-June Shin, Min-Ki Shin, Soo-Im Chang