Abstract: Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

Abstract: The present invention is directed to composition comprising Nigella sativa (NS) oil, wherein said oil comprises thymoquinone (TQ) at a concentration of at least 2% (w/w). The composition is further characterized by having a much lower free fatty acid concentration than prior art compositions. The composition, which has anti-inflammatory activity, may be formulated for oral administration to a mammalian subject, for the purpose of preventing or treating inflammatory conditions and other disorders.

Abstract: Compositions comprising select meroterpenes and a linoleic component and the use thereof in regulating the endocannabinoid system (ECS).

Abstract: Compositions comprising select meroterpenes and a linoleic component and the use thereof in regulating the endocannabinoid system (ECS), especially in controlling and/or reducing the levels of cortisol: thereby having a stress reducing or inhibition effect.

Abstract: The invention relates to a low sugar or sugar free concentrated polyphenolic extract comprising at least about 30% polyphenols (w/w) and a protein-polyphenol aggregate matrix comprising at least about 15% polyphenols (w/w). The invention further relates to methods of producing a low sugar or sugar free concentrated polyphenolic extract comprising (a) extracting a low sugar or sugar free plant tissue with an aqueous solvent to produce an extract having an aqueous portion and a solids portion; (b) filtering the extract to separate the aqueous portion from the solids portion; and (c) reducing the volume of the separated aqueous portion, and methods of producing a protein-polyphenol aggregate matrix comprising about 1% to about 40% polyphenols (w/w) using the low sugar or sugar free concentrated polyphenolic extract of the invention.

Abstract: To improve the fact that the main components of conventional deodorizing and antimicrobial agents are existing components, the effect and efficacy of which are known to some extent, and do not generate an effect better than predicted. The deodorizing and antimicrobial agent of the present invention has a loquat seed extract including non-volatile fatty acids and at least benzaldehyde and benzoic acid as a main raw material.

Abstract: A method of manufacturing an ulcer treatment is disclosed. Ulcer symptoms, including stomach pain, bloating, heartburn, nausea, and more, can be highly intrusive on a patient's life. In order to create a treatment, several acorns, particularly acorns from Quercus brantii, commonly known as a Persian Oak tree, are acquired. These acorns are sorted and subsequently washed in water to free them of any dirt or contaminants. The acorns are then crushed to separate the acorn nuts from their corresponding acorn shells. The shells are discarded, and the acorn nuts are washed in room-temperature water again to remove any nut impurities. The acorn nuts are then roasted in an oven for several minutes to remove the nut skin from the nut. The nut skin and the nut body are collected and pulverized separately to create an ulcer-treating powder. The ulcer-treating powder may subsequently be mixed into a solvent and ingested by the ulcer patient to treat the patient's ulcers and ulcer symptoms.

Abstract: The present invention relates to a process for producing an oil and a defatted cake by solid/liquid extraction. The process comprises a step of solid/liquid extraction using a solvent comprising 2-methyloxolane and water.

Abstract: In alternative embodiments, provided are compositions and methods for treating, enhancing the drug sensitivity of, and preventing the formation of cancer stems cells, including preventing or slowing the development or generation of a beta-3 (?3)-expressing, or integrin ?3 (ITG-B3)-expressing cancer or tumor cells. In alternative embodiments, provided are methods using histone acetyl transferase inhibitors and/or histone methyl transferase inhibitors to determine therapeutic values in cancer cells that induce an integrin ?3 (ITGB3) polypeptide expression. In alternative embodiments, provided are kits, blister packages, lidded blisters or a blister card or packet, clamshells, trays or shrink wraps, comprising at least one compound, composition or formulation used to practice a method as provided herein, and at least one Growth Factor Inhibitor.

Abstract: The present disclosure relates to bi-phase micellar liquid products that include ceramides and other components that are beneficial to the skin. In particular, the products include: (a) a fatty phase comprising one or more fatty compounds and one or more silicones; and (b) an aqueous phase comprising one or more ceramides, one or more water-soluble solvents, one or more surfactants, and water. The products are particularly unique because the ceramides are solubilized in the aqueous phase of the products. In addition to being useful for cleansing the skin, the products support natural lipid barrier function of the skin and improve skin hydration.

Abstract: The present invention relates generally to the field of flavan-3-ols. In particular, the present invention provides a way to increase the bioavailability of flavan-3-ols. Embodiments of the present invention relate to the use of at least one carbohydrate with a glycemic index of less than 50 in a composition comprising at least one flavan-3-ol for increasing the bioavailability of said flavan-3-ol.

Abstract: The present invention provides a novel method of manufacturing germinated plant seeds suitable for producing a large amount of phytoalexin, a method of manufacturing raw material seeds for germination induction for use in manufacture of the above germinated plant seeds, an extract composition of the germinated plant seeds and a screening method for a plant seed candidate for use in producing a target substance. The method of manufacturing raw material seeds for germination induction comprises a pre-treatment step of maintaining plant seeds under atmosphere conditions of a carbon dioxide concentration of 400 ppm or more and/or an oxygen concentration of 19 vol % or less continuously for 5 hours or more.

Abstract: A method for effecting angiogenesis in a subject at risk of or experiencing ischemia related to the heart, brain, kidney, intestine, and/or legs. The method involves administering Nigella sativa to the subject. The method may also treat ischemia.

Abstract: A method for treating fatty liver disease in a patient in need thereof, including a step of administering an effective amount of zoledronic acid. The fatty liver disease includes fatty liver disease caused by foodborne and hereditary factors, in particular non-alcoholic fatty liver. A dosage form of the zoledronic acid is an injection, a solution, a tablet, or a capsule.

Abstract: The invention relates to a topical composition containing a bilirubin-producing plant extract. In particular, the bilirubin-producing plant extract is obtained from the genus Stelitzia. When topically applied to skin, the composition is effective in accelerating the degradation of heme by-products such as bilirubin present in the skin.

Abstract: The present invention provides a composition for a medicinal or health effect of a treatment of liver fat and body fat, a reduction of blood pressure, an increase of the energy expenditure rate, a reduction of inflammatory C-reactive proteins and a reduction of plasma aminotransferase enzymes, comprising an effective amount of fucoxanthin alone or in combination with pomegranate seed oil, a pharmaceutically acceptable salt, a prodrug thereof, or a salt of the prodrug; and a method of using the same. The fucoxanthin may be used in pure form, or as a component of a brown marine vegetable extract.

Abstract: Provided herein are methods of using therapeutically effective compositions of sandalwood oil to treat, prevent or reduce the recurrence of Clostridium infections.

Abstract: A cereal extract is cosmetically used and obtained by at least one polar solvent. This cereal extract is used as a slimming agent in a slimming cosmetic composition. The cosmetic use makes it possible to achieve an effective slimming cosmetic care with a natural, nontoxic slimming agent.

Abstract: Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

Abstract: The present invention provides a composition comprising stearidonic acid (or an ester thereof) derived for example from Echium oil, and an additional lipid (derived for example from calendula oil) which enhances the pro-collagen effects of stearidonic acid. The composition is useful in reducing visible signs of aging of human or animal skin or a method of wound healing.

Abstract: The invention relates to a method for preparing a composition that is very rich in squalene produced by fermentation of micro-organisms. The method is characterized in that it comprises a purification step selected from the group including: supercritical CO2 extraction in a multi-stage counter-current fractionation column with extract reflux, and short-path molecular distillation.

Abstract: Milkweed seed oil administered to an animal relieves the symptoms of fibromyalgia and improves the health of the animal. Administering an effective amount of milkweed seed oil orally or to the skin around or near the symptom of fibromyalgia of an animal results in relief from the symptoms of fibromyalgia as compared to the symptoms experienced by the animal both before the milkweed seed oil was administered.

Abstract: The present invention provides use of alcohol extract of longan seeds for manufacturing a drug for treating kidney tissue dysfunction. Preferably, an ethyl acetate sub-fraction of the alcohol extract of longan seeds has a better effect in treating kidney tissue dysfunction.

Abstract: A sustained release lotion for deterring animals from licking made by combining an aqueous phase having at least one bittering agent and at least one humectant, herein the at least one bittering agent is present in the aqueous phase in the range of about 0.001 to 25.0 wt. %; wherein the humectant is present in the aqueous phase in the range of from about 1 to 99 wt. %; and an oil phase comprising at least one oil and at least one surfactant, wherein the surfactant is present in the oil phase in the range of from about 1 to 100 wt. %, and wherein the aqueous phase is added to the oil phase in a weight ratio of about 3:1 to 49:1 using low to medium shear mixing and wherein the lotion is hydrophobic and has sustained release properties.

Abstract: The invention relates to the use of norbixin and an urucum extract enriched in bixin and/or norbixin as a food. The invention also provides a food preparation comprising norbixin, bixin or an extract comprising at least bixin or norbixin, the preparation being intended to be administered orally, for the protection of mammalian skin against UV-radiation.

Abstract: The safflower seed beverage contains a safflower seed extract, a black sesame extract, at least one flavoring ingredient, and water. The safflower seed beverage is made by placing a mixture of safflower seeds, black sesame seeds, the at least one flavoring ingredient, and the water into a juicer and running the juicer to extract from the mixture the safflower seed beverage in a form of a drinkable stable emulsion. The black sesame seeds are in an amount of about 75 to 180% by weight of the safflower seeds and the carrots are in an amount of about 2,100 to 2,500% by weight of the safflower seeds. In addition, the water is in an amount of about 50 to 250% by weight of the safflower seeds.

Abstract: The invention provides methods for isolating and enhancing the levels of jasmonates from cacao plant sources. In a preferred embodiment, jasmonic acid and 12-hydroxy jasmonate sulfate are detected in various cocoa products, and the levels of these compounds can be manipulated to increase the beneficial health effects of a food product made with the cocoa products The invention includes methods to prepare edible products containing cocoa jasmonates.

Abstract: Canola protein isolates are provided which contain both albumin and globulin protein fractions that are soluble, transparent and heat stable in an acidic aqueous environment. The canola protein isolates are completely soluble in water at low pH, low in phytic acid and useful in products for human consumption, pet foods and aquaculture.

Abstract: A water-soluble anti-inflammatory cream is disclosed. The cream is a composition of between about 7.5% and about 30% by weight of a healing oil; between about 1% and about 6% by weight of an herbal extract; between about 0% and about 3.5% by weight of microencapsulated amino acids; and at least 39.4% by weight water.

Abstract: Nontoxic aglycones of a particular species of the family Sapotaceae are obtained for preparing cosmetics and pharmaceutical dermatological compositions. These aglycones are prepared with the use of coarse raw kernel, or by a plurality of kernel products as raw material that contain the biochemical substrates, namely related glycosides to the lucumin. The transformation products consist of benzaldehyde, the main constituent of the genin recovery, and mandelic acid and mandelamide, the main constituents of the sapogenins. The process for transformation into genin and sapogenins includes the use of exogenous ?-glycosidases other than from the family Sapotaceae as the biochemical transformation method into the respective enzymatic hydrolysis aglycones products, the genin plus sapogenins as obtained and after separation into the individual aglycones.

Abstract: A treatment protocol for use in the treatment of neurocutaneous syndrome is described and comprises at least one xanthone component, which may comprise at least one mangosteen component, and at least one detoxification component. Additional embodiments comprise at least one herbal component, at least one vitamin component, or a combination thereof. A method of treating a patient having neurocutaneous syndrome is described herein and comprises: providing at least one xanthone component, which may comprise at least one mangosteen component, providing at least one xanthone component, which may comprise at least one mangosteen component, to the patient, and administering the at least one detoxification component to the patient. Additional methods steps may include providing and administering at least one herbal component, providing and administering at least one vitamin component or a combination thereof.

Abstract: Phytoecdysones for use in improving muscle quality in obese and/or sarcopenic mammals, preferably, obese mammals subjected to a low-calorie diet. The phytoecdysones are advantageously incorporated into a food composition. The phytoecdysones can be derived from plants, such as quinoa.

Abstract: A Salvia hispanica L. derived seed oil extract composition of matter containing from 60-88% PUFAs in a ratio of from 3.1:1-3.3:1 of ALA to LA, 4-10% of C-18 mono-unsaturated fatty acid, 1-5% of C-18 saturated fatty acid and 4-8% of C-16 saturated fatty acid in a mixed triglyceride form stable at room temperature of 12-24 months containing a mixture of selected antioxidants.

Abstract: A method for producing pure guar flour and the use of hydroxy propyl trimethyl ammonium chloride—guar flour obtained according to the method in clear aqueous cosmetic formulations which are intended to be applied on hair and/or skin and which can be washed out or rinsed off as conditioning agents or depositing agents to dilute cosmetic formulations.

Abstract: A topical formulation comprising a Cannabis derived botanical drug product, wherein the concentration of tetrahydrocannabinol, cannabidiol, or both in the topical formulation is greater than 2 milligrams per kilogram.

Abstract: An organic skin moisturizer, which extends and improves the skin cells life cycle, comprised of Sea Buckthorn seed oil, Camellia seed oil, Argan seed oil, Pomegranate seed oil, Meadowfoam seed oil, d-alpha tocopherol, Lecithin oil, Rosemary essential oil, Tea Tree oil, Helichrysum oil, and Coffee Arabica oil. The oils are blended together resulting in a compound that is easily applied to the skin for superior results to keep the skin cells healthier longer. This compound was created to address the Hayflick limit, which is that all skin cells can only divide a specific number of times before the skin cell dies.

Abstract: An organic skin moisturizer, which extends and improves the skin cells life cycle, comprised of Sea Buckthorn seed oil, Tamanu oil, Meadowfoam seed oil, Behenyl alcohol, Vetiver oil, Vitamin E or d-alpha tocopherol, Lecithin oil, Tea tree oil, Helichrysum oil, Melissa oil, and the titanium dioxide. The oils are blended together resulting in a compound that is easily applied to the skin for superior results to keep the skin cells healthier longer. This compound was created to address the Hayflick limit, which is that all skin cells can only divide a specific number of times before the skin cell dies.

Abstract: Processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enzymes to the mixture in an amount sufficient to at least partially degrade the pomegranate solids; heating the mixture to a temperature that permits the maximum rate of catalysis of the enzyme; maintaining the temperature of the heated mixture for a time sufficient to allow at least partial degradation of the pomegranate solids; and removing residual insoluble solid materials from the mixture. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements.

Abstract: A composition having an extract of seed of Emblica officinalis. Methods of preparing extract of seed of Emblica officinalis. An amla seed blend composition having various ratios of extracts of seeds of Emblica officinalis. Nutraceutical or pharmaceutical methods for decreasing the total cholesterol, decreasing triglyceride, decreasing blood glucose level, enhancing HDL-C levels, increasing the HDL-C level to total cholesterol ratio, lowering HDL-C levels, decreasing the CRP level, decreasing the intima media thickening, reducing hair fall in mammals especially human beings. The extract or seed of Emblica officinalis, or the amla seed blend composition is more effective compared to extracts prepared from fruits of Emblica officinalis.

Abstract: Described herein are compositions comprising a nematicide intermixed with lecithin and a co-surfactant that form stable dispersions in water. Also disclosed are methods of controlling nematodes in soil by application of such compositions.

Abstract: An improved method for producing a coffee bean extract containing beneficial compounds.

Abstract: Disclosed herein are inventive stable homogenized biomass hetero-colloids, their production and uses. Such biomass hetero-colloids comprise biomass derived solid particle colloid matter and at least 15% (w/w) biomass derived soluble colloid matter. The novel biomass hetero-colloids provide an inventive approach for the application of biologically active compounds. Bio-actives are made available in an innovative form involving low intervention processing and enhancing the biological availability.

Abstract: The present invention relates to a plant extract from a low-tetrahydrocannabinol (THC) variety of Cannabis sativa subsp. sativa for the treatment of disease.

Abstract: The present invention provides a method for treating gastric ulcer and/or stomach cancer in a subject, which comprises administering to said subject an effective amount of an alcohol extract of dehulled adlay seeds. Preferably, an ethyl acetate sub-fraction of the alcohol extract of dehulled adlay seeds has a better effect in treating gastric ulcer and/or stomach cancer.

Abstract: A composition for topical application to human skin having an effective amount of cosmetically suitable components comprising at least one nut oil, at least one thickener and/or emulsifier component and water. The at least one nut oil includes a substantial proportion of macadamia nut oil, and the composition includes only sufficient emulsifier to render the composition suitable for topical application. The composition is especially suitable for the treatment of aged persons, where it can improve their general health, and also assists to reduce undesirable body odour.

Abstract: A composition for applying to skin suffering from acne to treat the acne, the composition comprising an extract of Malva neglecta. The Malva neglecta increases ceramide production at the area of skin affected by acne to treat and/or improve the acne. Additionally, the composition may include cholesterol.

Abstract: The present invention relates to a method for using the by-products of coffee in the production of proteins, polyphenols, vitamins and minerals, through methods of concentrating and conserving the mucilage and the pulp (husk) in order to obtain industrially processed coffee honey and/or pulp meal (husk), which is/are suitable for use in products for human or animal consumption, drugs, cosmetics or as raw materials for the production of alcohol for fuel (ethanol), wherein said process makes it possible to reduce the pollution of the environment by avoiding the waste of coffee by-products and to exploit the properties and advantages of same for producing the aforementioned products.

Abstract: An aqueous antiseptic composition for eliminating microorganisms that cause Bovine mastitis in dairy animals is disclosed. The composition comprises about 10 to 50% by volume of lemongrass oil and at least one solubilizing agent for solubilizing the lemongrass oil. The composition also comprises about 10 to 30% by volume of a carrier oil carrying the components of the composition and about 0.5 to 2% by volume of an electrolyte for providing conductivity for the composition. The composition further comprises an organic acid for adjusting the pH level of the composition and an antioxidant.

Abstract: Materials with high levels of unsaponifiable matter, such as extracts from plants, produce hydrolysates with unique properties. The application of a hydrolysis process to materials, particularly materials with a high level of unsaponifiables (e.g., at least 6 weight percent of the material), produces a product with properties significantly different from those products resulting from the conventional saponification of materials with less than 6 weight percent of unsaponifiables. The hydrolysates of the present invention are substantive, resisting both physical and aqueous-based removal from skin and hair, exhibit a unique surfactant property, and are not foaming agents with water. Hydrolysates according to the present invention may be used to enhance the performance of cosmetics and pharmaceuticals.

Abstract: Described are four, novel supercritical fluid extracts of Nigella sativa seeds containing about 0.01 to about 40% (w/w) thymoquinone that can be produced using commercial-scale quantities of N. sativa seeds. These formulations provide antioxidant, thermogenic, anti-inflammatory and other biological activities qualitatively and quantitatively distinct from thymoquinone alone and are useful as dietary supplements or therapeutics for inflammation-related disorders.