Containing Or Obtained From A Stem, Stalk, Branch, Or Twig, (aka Ramus Or Ramulus) Patents (Class 424/779)
  • Patent number: 11376295
    Abstract: A method for preparing a Rhus verniciflua Stokes extract with an increased content of fisetin, the method including adding reacting at least one catalyst selected from the group consisting of platinum, chromium, nickel, silicon, copper, and oxides of these metals, to a Rhus verniciflua Stokes extract or a concentrated Rhus verniciflua Stokes extract and conducting reaction to convert fustin contained in the Rhus verniciflua Stokes into fisetin, and a functional health food composition for preventing or ameliorating cancer, or an anticancer pharmaceutical composition for inhibiting metastasis of cancer, as a main component, containing the Rhus verniciflua Stokes extract with an increased content of fisetin, prepared by the method which provides a very safe and efficient method that is capable of preparing an extract that exhibits improved antioxidant activity and anticancer activity by increasing the content of the main functional ingredients of natural extracts, and an anticancer agent composition.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: July 5, 2022
    Assignee: Medience Co., Ltd
    Inventors: Sang Jae Park, Kyoung Hee Kim
  • Patent number: 9040104
    Abstract: Disclosed are compositions that include Docynia delavajy extract, Elaeagnus lanceolatus extract, or a combination of such extracts.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: May 26, 2015
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines
  • Patent number: 9040103
    Abstract: The present invention concerns various compositions comprising the essential oil of Origanum compactum or of Aniba rosaeodora or one of their constituents, preferably a major constituent, for use in the targeted treatment and prevention of keratoses in the transformation phase and of carcinomas originating from these keratoses, and more particularly of keratoses induced by solar radiation on the skin of a subject. More particularly, the present invention concerns compositions based on the essential oil of oregano or of rosewood, or on linalool, thymol or carvacrol.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: May 26, 2015
    Assignees: L'Oreal, Institut Curie, Centre National de la Recherche Scientifique
    Inventors: Laurent Marrot, Jérémie Soeur, Meng-Er Huang
  • Patent number: 9028893
    Abstract: Active fractions exhibiting anti-tuberculous activity from the plant Byttneria herbecea (family—Sterculiaceae) are described. Methanol extracts of the aerial part of Byttneria herbecea exhibited activity against MtbGS in primary screening of biosynthetic assay. Subsequent fractionation was carried out in organic solvents. Out of all these, two fractions (fraction D and K) are exhibiting inhibitory activity against M. tuberculosis glutamine synthetase activity. These fractions D and K are inhibiting 74% and 44% respectively at 7.5 mg/ml concentrations. The determined IC50 value of the fraction K is found to be 4.5 mg/ml from the dose response curve against the purified Mycobacterium tuberculosis Glutamine Synthetase. The IC50 value for M. bovis BCG is 1.56 ?g/ml. It was observed that there was no significant effect on proliferation of HL-60 cell line at 10×MIC levels of the hits. This data indicated that these compounds could be initially considered to be safe.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: May 12, 2015
    Assignee: Council of Scientific & Industrial Research
    Inventors: Dhiman Sarkar, Swati Pramod Joshi, Upasana Singh, Ketaki Dilip Shurpali, Roshan Rajan Kulkarni
  • Publication number: 20150125560
    Abstract: The present invention relates to a pharmaceutical composition for preventing and treating cancer which comprises the extracts of Artocarpus altilis fruits, leaves, or stems, or the fractions thereof as active ingredients. The extracts of Artocarpus altilis fruits, leaves, or stems, or the fractions thereof, according to the present invention, suppress the activity of signal transducer and activator of transcription3 (STAT3) which plays an important role in the growth of a cancer cell line and in the immune function of the human body, and can thus be effectively used in the prevention and treatment of cancers such as colorectal cancer, stomach cancer, prostate cancer, breast cancer, renal cancer, liver cancer, brain tumor, lung cancer, uterine cancer, colorectal cancer, bladder cancer, or pancreatic cancer.
    Type: Application
    Filed: July 26, 2013
    Publication date: May 7, 2015
    Inventors: Byoung-Mog Kwon, Dong Cho Han, Joongku Lee, Yoon-jeong Jeon, Sang Ho Choi
  • Patent number: 8986756
    Abstract: The present invention is related to a combined herb composition comprising herbs of Coriolus versicolor, Astragalus membranaceus Bunge, and additionally comprising at least one herb selected from group consisting of Schisandra chinensis, and Artemisia capillaris, according to the need for the prevention and treatment of liver disease and methods of using the above crude drug composition and pharmaceutical composition as hepato-protective agent.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: March 24, 2015
    Inventor: Jung Sik Lee
  • Patent number: 8980227
    Abstract: The present invention relates, e.g., to a system for treating damaged skin, comprising a cosmeceutical formulation comprising about 1-10% of a mixture of perfluorocarbons (PFC's) of at least three different molecular weights, and about 0.001-5% hyaluronic acid (HA) of molecular weight about 100 kDa or less, packaged in an aerosol spray container.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: March 17, 2015
    Assignee: Kate Somerville Skincare, LLC
    Inventors: Kate Somerville, Fred Khoury
  • Patent number: 8980228
    Abstract: The present invention relates, e.g., to a system for treating damaged skin, comprising a cosmeceutical formulation comprising about 1-10% of a mixture of perfluorocarbons (PFC's) of at least three different molecular weights, and about 0.001-5% hyaluronic acid (HA) of molecular weight about 100 kDa or less, packaged in an aerosol spray container.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: March 17, 2015
    Assignee: Kate Somerville Skincare, LLC
    Inventors: Kate Somerville, Fred Khoury
  • Patent number: 8974842
    Abstract: The present invention relates to a method for preparing a lipophilic extract from lignified portions of vine, such as shoots, stock and roots, characterized in that said method comprises a step for extraction from said lignified portions with an apolar solvent; to an extract obtained by such a method; to the use of such an extract as an excipient in a cosmetic composition; and to a cosmetic composition comprising such an extract.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: March 10, 2015
    Assignee: L V M H Recherche
    Inventors: Virginie Pecher, Patrice Andre
  • Publication number: 20150050316
    Abstract: Disclosed is a cosmetic or dermatological preparation which comprises one or more extracts of Saxifraga oppositifolia (purple saxifrage) and/or one or more extracts of Soldanella alpina (alpine snowbell). The use of these extracts to combat extrinsic and intrinsic skin aging is likewise described.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 19, 2015
    Inventors: Daniel STANGL, Bernhard DUDLER
  • Patent number: 8936817
    Abstract: Gymnema sylvestre extracts together with extracts of one or more of Boswellia serrata, Tinospora cordifolia and Commiphora mukul provide effective weight loss management when administered to a patient desiring weight loss management. Administration of the foregoing also reduces the leptin-to-adiponectin ratio in the patient's blood serum.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: January 20, 2015
    Assignee: Ayurvedic-Life International, LLC
    Inventor: Arun K. Chatterji
  • Patent number: 8916209
    Abstract: A method of making a low molecular weight fraction of Phyllanthus niruri is provided. Such low molecular weight fraction is particularly useful for treating the signs of skin aging.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: December 23, 2014
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Michelle Garay, Simarna Kaur, Michael Southall, Ping Wen
  • Publication number: 20140370135
    Abstract: The invention provides methods for treating and/or preventing the recurrence of a senile cataract, and/or for inhibiting the development of a senile cataract and/or an incipient senile cataract, in a human or animal subject. The invention further provides nutraceutical compositions suited for the same, derived from an extract of the plant Capraria biflora. The compositions comprise the extract in a therapeutically sufficient amount for the treatment and/or prophylaxis of a senile cataract in a human and/or animal subject.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Applicant: BURROWS ENTERPRISES, LLC
    Inventor: Adria BURROWS
  • Patent number: 8906430
    Abstract: Disclosed is the use of hypericum (Hypericum perforatum L.) tip extracts containing hypericin, of hypericin, to prepare medicinal products and/or food supplements for the treatment of neuropathic pain.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: December 9, 2014
    Assignee: Aboca S.p.A. Societa' Agricola
    Inventors: Valentino Mercati, Franco Francesco Vincieri, Anna Rita Bilia, Carla Ghelardini, Nicoletta Galeotti
  • Publication number: 20140301962
    Abstract: Methods of using extracts of Serissa japonica to impart benefits to skin and/or improve skin conditions resulting from aging or damaged skin.
    Type: Application
    Filed: December 11, 2012
    Publication date: October 9, 2014
    Inventors: Qian Zheng, John W. Lyga, Uma Santhanam, Permanan Raaj Khusial, Ying Chen
  • Patent number: 8846116
    Abstract: The present invention relates to methods and products, such as wet wipes and absorbent articles, that are capable of imparting a health benefit when used in the intended fashion. More specifically, the products described herein comprise one or more botanical compounds, which are capable of selectively controlling the balance of flora on the skin. The compounds may enhance the adherence of healthy flora to the surface of skin or mucosa, inhibit the growth of problem flora on or around the skin surface, or inhibit the adherence of problem flora to the surface of skin or mucosa, or any combination thereof.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: September 30, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: David W. Koenig, Beth A. Lange, Christine L. Schneider
  • Patent number: 8778424
    Abstract: Provided are compositions containing a unique combination of vitamin B1, vitamin B6, vitamin B12, folic acid, magnesium glycinate, ferric glycinate, L cysteine, biotin, Polygonum multiflorum, and Emblica officinalis. Methods of increasing hair volume in a subject by administering to the subject a composition containing vitamin B1, vitamin B6, vitamin B12, folic acid, magnesium glycinate, ferric glycinate, L cysteine, biotin, Polygonum multiflorum, and Emblica officinalis are also included.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: July 15, 2014
    Inventor: Tasneem Bhatia
  • Patent number: 8771758
    Abstract: The present disclosure relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents which increase expression levels genes, collagen replacement and retention, and cell proliferation of epidermis and dermis associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and aesthetic appearance of skin.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: July 8, 2014
    Assignee: Avon Products, Inc.
    Inventor: Dmitri S. Ptchelintsev
  • Patent number: 8758837
    Abstract: A method for removing pests from harvested vegetables has steps of extracting a first portion of harvested vegetables to obtain a vegetable cleanser, and cleaning a second portion of harvested vegetables with the vegetable cleanser, such that pests residing on the second portion of harvested vegetables are removed from the second portion of harvested vegetables, wherein the first portion of harvested vegetables and the second portion of harvested vegetables independently contain vegetables selected from the group consisting of vegetables belonging to the families of Cruciferae, Compositae, Chenopodiaceae and Amaranthaceae. The aforementioned method is effective at removing pests from harvested vegetables and satisfies urgent needs to reduce use of chemical pesticides.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: June 24, 2014
    Assignee: Food Industry Research & Development Institute
    Inventors: Tin-Yin Liu, Yi-Kai Wang, Mei-Ling Lu
  • Publication number: 20140154342
    Abstract: Provided herein are compositions of sandalwood heartwood oil and methods of making and using such compositions.
    Type: Application
    Filed: July 27, 2012
    Publication date: June 5, 2014
    Applicant: SANTALIS PHARMACEUTICALS INC.
    Inventors: Ian Clements, Paul Castella, Corey Levenson
  • Publication number: 20140147394
    Abstract: The present invention provides a non-parenteral and non-ocular herbal synergistic detoxifier composition effective for blood purification, blood detoxification and in the treatment and management of disorders related to accumulation of toxins in the body having synergistic effect of its components in specific ratio, better bio availability wherein the amount of dose administered is remarkably low. The formulation of synergistic herbal composition has better patient compliance in the terms of palatability, ease of administration and is formulated in the form of syrup, lozenges/candies/jujubs/mouth freshener, sub-lingual tablets or chewable tablets. The present invention also provides a method of preparation of this formulation.
    Type: Application
    Filed: October 25, 2011
    Publication date: May 29, 2014
    Inventor: Manu Chaudhary
  • Patent number: 8734866
    Abstract: The present invention relates to a composition for treatment and prevention of cardiovascular diseases, containing an extract of Lindera obtusiloba. More particularly, the extract of Lindera obtusiloba strongly inhibits NAD(P)H oxidases, which are the main cause of vascular diseases, and at the same time, regulates contraction and relaxation of vascular smooth muscles to manifest a potent vasorelaxant effect, thereby improving the blood pressure regulation and vascular endothelial dysfunction. Therefore, a composition containing this as an active ingredient can be usefully utilized as a pharmaceutical product or health functional food product for the prevention and treatment of cardiovascular diseases.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: May 27, 2014
    Assignees: Yang Ji Chemical Co., Ltd., Han Wha Pharma Co., Ltd.
    Inventors: Min-Ho Oak, Jung-Ok Lee, Woon-Sun Choi, Jung-Duk Sohn, Jong-Hoon Kim, Jee Woong Lim, Chung Keun Rhee
  • Patent number: 8697149
    Abstract: The invention provides extracts and preparations based on the species Tulbaghia violacea (Harv.) (wild garlic), which elicits a significant antimicrobial, preferably antifungal activity in vitro and in vivo, even under field and glasshouse conditions. Moreover, these extracts deriving from the soil parts as well as of the aerial parts of the plant elicit a significant bio-stimulatory activity, expressed, above all, by an increased growth metabolism supporting seed growth. Furthermore, combined extracts or preparations from Tulbaghia violacea and species of the genus Agapanthus show a higher antifungal and bio-stimulatory efficacy as compared to the extracts or preparations of the single species, indicating that synergism is participated in the involved biological processes.
    Type: Grant
    Filed: June 24, 2006
    Date of Patent: April 15, 2014
    Assignees: Agrarforum AG, Agrarforum SA (Pty) Ltd.
    Inventor: Johannes Christiaan Pretorius
  • Publication number: 20140093598
    Abstract: The invention relates to extracts and compositions from Gnetum africanum and methods for obtaining the extracts, wherein the extracts comprise resveratrol and have anti-inflammatory activity. Methods of using the extracts for the prevention and/or treatment of inflammatory diseases, and compositions which comprise the extracts including cosmetic compositions are also encompassed.
    Type: Application
    Filed: July 26, 2011
    Publication date: April 3, 2014
    Applicant: PHARMAFRI-CAN INC.
    Inventors: Carole Robert, Sue Wehner
  • Publication number: 20140072664
    Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of atopy comprising the extract of Daphne genkwa, the fraction thereof, of the compound isolated from the same as an active ingredient. More precisely, the extract of Daphne genkwa, the fraction thereof, or the compound isolated from the same, genekwadapnin or yuanhuacine, of the present invention can increase the secretion of cytokine in Th1 immune cells and suppress atopy in the atopy mouse model, so that the extract of Daphne genkwa, the fraction thereof, or the compound isolated from the same of the present invention can be effectively used for the prevention or treatment of atopy.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 13, 2014
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Jae Wha Kim, Kyung Seop Ahn, Ho Bum Kang, Sei Ryang Oh, Jae Jong Go, Joo Heon Kim, Jang Mi Sun, Jae Sung Song, Hyun Woo Oh, Da Jung Ji
  • Patent number: 8668944
    Abstract: A method for making and applying a topical oil and composition thereof, combining the healing properties of the Noni plant with a topical application for treating physical ailments. The topical oil disclosed includes an oil derived from raw leaves, stems, and buds of a noni plant; a carrier oil; and vitamin E oil.
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: March 11, 2014
    Inventor: Donna Greco
  • Publication number: 20140030289
    Abstract: The invention provides compositions and methods for inducing apoptosis in a cancer cell or a cell transformed by Epstein-Barr virus (EBV). Specifically, the invention provides Beta-Caryophyllene or a composition thereof to induce apoptosis. The invention further provides treating lymphoma or Epstein-Barr virus (EBV) associated disease in a subject by administering Beta-Caryophyllene or a composition thereof.
    Type: Application
    Filed: February 6, 2012
    Publication date: January 30, 2014
    Inventors: Rivka Ofir, Shimon Rachmilevich, Eitan Amiel, Nativ Dudai, Tattiana Rabinski, Shimshon Ben-Yehoshua
  • Patent number: 8637093
    Abstract: A composition for topical application to the skin comprises a cocoa polyphenol extract in combination with an SUS-rich fat, wherein the cocoa polyphenol extract is present in an amount of less than 15% by weight based on the weight of the SUS-rich fat, and a cosmetically acceptable carrier. The composition and the extract that it contains may increase skin elasticity and thickness and/or have an anti-wrinkle effect, may cause the depigmentation of age spots, improve skin renewal and/or reduce skin dryness such as reducing discomfort of chapped hands.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: January 28, 2014
    Assignee: Barry Callebaut AG
    Inventors: Herwig Bernaert, Leen Allegaert
  • Publication number: 20130323341
    Abstract: The present invention relates to a composition comprising extract of the plant Ficus arnottiana. The invention also relates to a process for the preparation of the composition and to the composition for the use in the treatment of viral infections, particularly caused by herpes simplex viruses (HSV). The invention further relates to a method of treating a viral infection in a mammal comprising administering to the mammal a therapeutically effective amount of the composition.
    Type: Application
    Filed: February 13, 2012
    Publication date: December 5, 2013
    Applicant: PIRAMAL ENTERPRISES LIMITED
    Inventors: Becky Mary Thomas, Arvind Saklani, Natasha Kapoor, Arno Appavoo Enose, Satish Namdeo Sawant, Ritu Kaushik, Rupa Bhowmick, Ashish Malani
  • Patent number: 8597690
    Abstract: A method of treating a respiratory disease in an animal comprising the steps of administering to the animal an effective amount of a pharmaceutical composition comprising 1.5 parts by weight powdered fennel, 2.0 parts by weight powdered rhubarb, 1.0 part by weight powdered glycyrrhiza, 2.0 parts by weight powdered phellodendron bark, 1.0 part by weight powdered zedoary, 1.5 parts by weight powdered picrasma wood, 1.0 part by weight powdered matricaria chamomilla, 1.5 parts by weight powdered geranium herb, 1.0 part by weight powdered ginseng, 1.5 parts by weight powdered citrus unshiu peel, 1.0 part by weight powdered scutellaria root, 1.0 part by weight powdered magnolia bark, 2.0 parts by weight powdered oyster shell, 1.0 part by weight powdered cyperus rhizome, 2.0 parts by weight powdered platycodon root, 2.0 parts by weight powdered melia azedarach, 1.0 part by weight powdered cnidium rhizome, 2.0 parts by weight sodium bicarbonate and 4.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: December 3, 2013
    Assignee: Nakamori Pharmaceutical Co., Ltd.
    Inventor: Toshio Nakamori
  • Publication number: 20130316030
    Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract of Homonoia riparia Lour. or the fraction thereof as an active ingredient. More particularly, the extract of Homonoia riparia Lour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.
    Type: Application
    Filed: March 7, 2011
    Publication date: November 28, 2013
    Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Jin Sook Kim, Jung Hyun Kim, Young Sook Kim, Chan-Sik Kim, Ohn Soon Kim, Eun Jin Shon, Nam-Hee Yoo, Yun Mi Lee, Dong Ho Jung
  • Publication number: 20130302279
    Abstract: The present invention relates to a novel use of naturally occurring plants, mushroom, extracts thereof that exhibit properties as HCV NS5B polymerase inhibitors.
    Type: Application
    Filed: April 22, 2013
    Publication date: November 14, 2013
    Applicants: University of Medicine & Dentistry of New Jersey, Rutgers, The State University of New Jersey
    Inventors: James E. Simon, Qingli Wu, Neerja Kaushik-Basu
  • Publication number: 20130287873
    Abstract: The disclosure provides a pharmaceutical composition for promoting wound healing, including an effective amount of a Sambucus plant or an Isatis plant as an active ingredient for promoting wound healing; and a pharmaceutically acceptable carrier or medium, wherein the Sambucus plant is Sambucus formosana Nakai, and the Isatis plant is Isatis indigotica Fort.
    Type: Application
    Filed: April 26, 2013
    Publication date: October 31, 2013
    Applicant: Industrial Technology Research Institute
    Inventors: Pei-Yi TSAI, Hsiang-Wen TSENG, Yen-Chun CHEN, Hui-Chun HSU, Yi-Hung WEN, Chun-Chung WANG, Shu-Jiau CHIOU
  • Publication number: 20130280320
    Abstract: The present invention relates to a method for producing articles impregnated with at least one plant substance from at least one plant, characterized in that it comprises the following steps: a) Extraction and/or pressing of at least one plant (V1), or at least one part of said plant, producing a liquid plant extract (E1)) and a solid fibrous residue (R1), then b) Separation of said plant extract (E1) from said fibrous residue (R1), and c) Destructuring of said fibrous residue (R1), d) Production of a fibrous web or of an article made from the fibrous residue (R1) obtained in step c), and e) Impregnation of said fibrous residue (R1) with (i) at least said plant extract (E1), which is optionally concentrated, purified, flavored and/or fragranced, with (ii) at least one water-soluble or liposoluble plant substance isolated from said plant extract (E1), with (iii) at least one composition comprising at least one optionally concentrated, purified, flavored and/or fragranced water-soluble or liposoluble substan
    Type: Application
    Filed: October 13, 2011
    Publication date: October 24, 2013
    Applicant: SCHWEITZER-MAUDUIT INTERNATIONAL, INC
    Inventor: Bernard Mompon
  • Patent number: 8557304
    Abstract: The present invention relates to a method of isolating phenolic secondary plant constituents from plant material using a microporous membrane which displays affinity ligands for the phenolic secondary plant constituents.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: October 15, 2013
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Hans-Heinrich Hoerl, Wolfgang Demmer, Rene Faber
  • Patent number: 8507017
    Abstract: A method for decreasing nicotine and other substance use in humans is disclosed. Tetrahydroberberine (THB) and its analogs, l-Tetrahydropalmatine (l-THP) and l-Stepholidine (l-SPD), are present in and can be isolated from several plants in the Magnoliidae superorder. According to the disclosed method, THB and its analogs are used to block nicotine-induced DA release, and modulate heterologous or homoeric expression of human nicotinic acetylcholine receptors (nAChR) in humans. Specifically, THB exhibits bi-directory modulation of ?4?2-nAChR-mediated currents induced by nicotine. THB also shows predominant inhibition on homologously expressed ?7-nAChR function. Thus, according to the disclosed method, THB is used to simultaneous blockade midbrain DA system function, the brain reward center, and neuronal ?4?2- and ?7-nAChR function, the major nicotine targets in the brain. Therefore, THB and its analogs serve as a novel class of natural compounds to decrease nicotine dependence in humans.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: August 13, 2013
    Assignee: Arizona Health Consulting Group, LLC
    Inventor: Jie Wu
  • Publication number: 20130196010
    Abstract: The invention provides methods for treating and/or preventing the recurrence of a senile cataract, and/or for inhibiting the development of a senile cataract and/or an incipient senile cataract, in a human or animal subject. The invention further provides nutraceutical compositions suited for the same, derived from an extract of the plant Capraria biflora. The compositions comprise the extract in a therapeutically sufficient amount for the treatment and/or prophylaxis of a senile cataract in a human and/or animal subject.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 1, 2013
    Applicant: BURROWS ENTERPRISES, LLC
    Inventor: BURROWS ENTERPRISES, LLC
  • Patent number: 8496975
    Abstract: The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: July 30, 2013
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • Publication number: 20130189383
    Abstract: The present invention relates to a method for inhibition of xanthine oxidase comprising administrating an effective amount of the extracts from Acacia spp.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 25, 2013
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventor: NATIONAL TAIWAN UNIVERSITY
  • Patent number: 8491947
    Abstract: Disclosed are methods and preparations useful for reducing fat at a targeted area(s) on a human. The preparations comprise as an active ingredient an adipolysis enhancing (i.e., fat-melting) amount of an active ingredient, paeoniflorin (PF). The preparations may be provided as an injectable preparation or as a topically applied preparation, such as in the form of a crème or lotion. In topical preparations, the active ingredient paeoniflorin may be contained within nanospheres, such as albumin nanospheres. The PF-containing preparations may also include a permeant, such as azone. The method may be accompanied by the application of ultrasound to the area being treated prior to, during or after, or prior to, during, and after application of the paeoniflorin preparation to an area of the body in which fat reduction is desired.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: July 23, 2013
    Inventor: Bakr Rabie
  • Patent number: 8481095
    Abstract: A method for inhibiting at least one selected from the group consisting of oxidation, the activity of matrix metalloproteinase (MMP), the expression of matrix metalloproteinase, and the phosphorylation of mitogen-activated protein kinase (MAP kinase) in a mammal, comprising administrating to the mammal an effective amount of a Flemingia macrophylla extract.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: July 9, 2013
    Assignee: China Medical University
    Inventors: Hsiu-Mei Chiang, Kuo-Ching Wen
  • Publication number: 20130171276
    Abstract: The present invention relates to a pharmaceutical composition for suppressing obesity or lowering blood sugar which comprises Cudrania tricuspidata extract and Coix lachryma-jobi extract, and more specifically relates to a pharmaceutical composition for suppressing obesity or lowering blood sugar which comprises Cudrania tricuspidata extract and Coix lachrymajobi extract, to a functional health food or food additive composition for suppressing obesity or lowering blood sugar which comprises Cudrania tricuspidata extract and Coix lachryma-jobi extract, to a tablet having an obesity-suppressing function and blood-sugar lowering effect which is produced using Cudrania tricuspidata and Coix lachryma-jobi as principal raw materials, and to a production method therefor.
    Type: Application
    Filed: September 9, 2011
    Publication date: July 4, 2013
    Applicant: KOREA FOOD RESEARCH INSTITUTE
    Inventors: Hyun Ku Kim, Jeong Ryong Do, Chan Kyu Han
  • Patent number: 8460719
    Abstract: A first composition including copper sulfate, citric acid, ammonium carbonate, propionic acid, Yucca schidigera extract, and antioxidants from essential oils and a second composition including sodium acid sulfate, citric acid and antioxidants from essential oils are sequentially administered to livestock through the drinking water supply to reduce the incidence of diseases such as Clostridium, E. coli and Salmonella and, thus, reliance on antibiotics to control the diseases.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: June 11, 2013
    Assignee: JRW Technologies, LLC
    Inventor: Randy H. Olsen
  • Patent number: 8431170
    Abstract: A composition having antimicrobial activity is provided. The composition includes a compound mixture obtained from pulverized and/or extracted wood material that contains polyphenols (i) lignans, (ii) stilbenes and (iii) oligomers of lignans, stilbenes juvabiones or flavonoids. The cytotoxicity of the polyphenols in the compound mixture is at least ten times lower compared to butylated hydroxytoluene (BHT) and does not irritate the skin in a so-called single patch test at 0.1 wt %. The composition further includes an antimicrobial agent such as betulin, betulonic acid, betulinic acid, betuloinic acid, resveratrol or ethylhexyl glyceryl. The composition can be used in cosmetic and hair care products.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: April 30, 2013
    Assignee: Oy Granula AB Ltd.
    Inventor: Thomas Ahlnäs
  • Publication number: 20130045290
    Abstract: The present invention relates, e.g., to a system for treating damaged skin, comprising a cosmeceutical formulation comprising about 1-10% of a mixture of perfluorocarbons (PFC's) of at least three different molecular weights, and about 0.001-5% hyaluronic acid (HA) of molecular weight about 100 kDa or less, packaged in an aerosol spray container.
    Type: Application
    Filed: August 16, 2012
    Publication date: February 21, 2013
    Applicant: Kate Somerville Skincare, LLC
    Inventors: Kate Somerville, Fred Khoury
  • Publication number: 20130040007
    Abstract: Active fractions exhibiting anti-tuberculous activity from the plant Byttneria herbecea (family—Sterculiaceae) are described. Methanol extracts of the aerial part of Byttneria herbecea exhibited activity against MtbGS in primary screening of biosynthetic assay. Subsequent fractionation was carried out in organic solvents. Out of all these, two fractions (fraction D and K) are exhibiting inhibitory activity against M. tuberculosis glutamine synthetase activity. These fractions D and K are inhibiting 74% and 44% respectively at 7.5 mg/ml concentrations. The determined IC50 value of the fraction K is found to be 4.5 mg/ml from the dose response curve against the purified Mycobacterium tuberculosis Glutamine Synthetase. The IC50 value for M. bovis BCG is 1.56 ?g/ml. It was observed that there was no significant effect on proliferation of HL-60 cell line at 10×MIC levels of the hits. This data indicated that these compounds could be initially considered to be safe.
    Type: Application
    Filed: September 21, 2012
    Publication date: February 14, 2013
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventor: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEA
  • Publication number: 20130028849
    Abstract: The present invention concerns a novel agent which is capable of stimulating the expression of LOXL and of increasing quality and functionality of collagen fibres and has anti-oxidizing, anti-elastase, anti-MMP properties as well as its use in producing cosmetic or pharmaceutical compositions, especially dermatological compositions, or food compositions.
    Type: Application
    Filed: December 23, 2010
    Publication date: January 31, 2013
    Applicant: BASF Beauty Care Solutions France S.A.S.
    Inventors: Valérie Cenizo, Nabil Abdul-Malak, Valérie Andre
  • Publication number: 20120308677
    Abstract: The present invention relates to a pharmaceutical composition for treating and preventing inflammatory diseases comprising an ethyl acetate fraction of dried extract of Trachelospermi caulis as an active ingredient and a method for producing the fraction. More particularly, the present invention relates to a composition for preventing and treating inflammatory diseases comprising an ethyl acetate fraction of dried extract of Trachelospermi caulis as an active ingredient, in which the extract of Trachelospermi caulis is refined and concentrated to contain 0.05˜12% by weight of arctigenin as an index material, and a method for producing the fraction.
    Type: Application
    Filed: September 25, 2009
    Publication date: December 6, 2012
    Applicant: Shin-il Pharmaceutical Co., Ltd.
    Inventors: Jeong Min Lee, Jee Hun Park, Jaehoon You, Kyoungmi Noh, Sena Kim, Eunsook Ahn, Young Suk Lee, Young June Lee, Wahn Soo Choi
  • Publication number: 20120308676
    Abstract: The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-? (IFN-?) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.
    Type: Application
    Filed: November 3, 2010
    Publication date: December 6, 2012
    Inventors: Sei-Ryang Oh, Jae Wha Kim, Hyeong-Kyu Lee, Kyung Seop Ahn, Doo Young Kim, Jung Hee Kim, Jae Sung Song, Ho-Bum Kang, Inpyo Choi
  • Patent number: 8298593
    Abstract: A first composition including copper sulfate, citric acid, ammonium carbonate, propionic acid, Yucca schidigera extract, and antioxidants from essential oils and a second composition including sodium acid sulfate, citric acid and antioxidants from essential oils are sequentially administered to livestock through the drinking water supply to reduce the incidence of diseases such as Clostridium, E. coli and Salmonella and, thus, reliance on antibiotics to control the diseases.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: October 30, 2012
    Assignee: JRW Technologies, LLC
    Inventor: Randy H. Olsen