Oxygen Or Sulfur Heterocycle Patents (Class 424/78.13)
-
Patent number: 8937100Abstract: Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.Type: GrantFiled: October 22, 2013Date of Patent: January 20, 2015Assignee: Cognis IP Management GmbHInventors: Philippe Moussou, Olga Freis, Louis Danoux, Philippe Grisoni, Laurent Bailly
-
Publication number: 20140079662Abstract: COMPOSITONS AND METHODS FOR TREATING RESPIRATORY DISORDERS WITH DOXOFILLINE.Type: ApplicationFiled: September 14, 2012Publication date: March 20, 2014Inventors: William Wayne Howard, Russell Francis Somma
-
Publication number: 20130315995Abstract: The present invention provides a tablet comprising a compressed tablet core which comprises at least about 80% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 80% by weight of an aliphatic amine polymer resin. The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 80% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.Type: ApplicationFiled: May 2, 2013Publication date: November 28, 2013Applicant: GENZYME CORPORATIONInventor: GENZYME CORPORATION
-
Patent number: 8592484Abstract: Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.Type: GrantFiled: March 16, 2010Date of Patent: November 26, 2013Assignee: Cognis IP Management GmbHInventors: Philippe Moussou, Olga Freis, Louis Danoux, Philippe Grisoni, Laurent Bailly
-
Publication number: 20130034503Abstract: A method and compositions for treating a patient that prevent or reduce drug abuse and overdose events.Type: ApplicationFiled: February 14, 2012Publication date: February 7, 2013Inventors: William Wayne Howard, Sheldon Kavesh, Russell Francis Somma
-
Patent number: 8337890Abstract: A coated drug-ion exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. The drug-ion exchange resin complex is in admixture with a release retardant. The coating is a polyvinyl acetate polymer and a plasticizer. Methods of making and products containing this coated complex are described.Type: GrantFiled: March 12, 2010Date of Patent: December 25, 2012Assignee: Tris Pharma IncInventors: Ketan Mehta, Yu-Hsing Tu
-
Publication number: 20120201887Abstract: A pharmaceutical composition in the form of a tablet including a first portion and a second portion, wherein said first portion includes guaifenesin having an immediate release profile and a second drug having a sustained release profile, and wherein the second portion includes guaifenesin having a sustained release profile. The second drug can be in the form of a drug-resin complex. The second drug can be either an anti-tussive or a decongestant. The drug-resin complex includes a drug complexed to an ion exchange resin. The ion exchange resin can be a polystyrene sulfonate resin, polacrilex resin, polacrilin potassium, cholestyramine resin, or a colestyramine resin. The drug-resin complex can be provided with a coating, the coating thickness being selected to obtain the desired release profile. The drug-resin complex can be provided with a coating level of from 5% to 50%. The coating level can be from 10% to 35%.Type: ApplicationFiled: February 4, 2011Publication date: August 9, 2012Applicant: Reckitt Benckiser LLCInventors: Nils Ahlgren, Mark Nuttall, Jeannie Wong, Venkatesh Balasubramanian, Craig Belongie, Ashfaq Khan, Neil Campbell Muir
-
Publication number: 20120148672Abstract: A sustained release formulation for opioid drugs is described. The formulation contains an opioid-ion exchange resin complex having a hybrid coating. The hybrid coating contains a cured polyvinylacetate polymer and a pH-dependent enteric coating layer mixed therein. Also provided are methods of making and using same.Type: ApplicationFiled: February 17, 2012Publication date: June 14, 2012Applicant: Tris Pharma, Inc.Inventors: KETAN MEHTA, Yu-Hsing Tu, Alivia Chaudhuri, Ashok Perumal
-
Patent number: 8188108Abstract: A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, levorphanol, codeine, acetaminophen and combinations of these analgesics. The composition is formulated for oral administration as a liquid or solid dosage form for immediate, slow, delayed or sustained-release characteristics.Type: GrantFiled: May 31, 2011Date of Patent: May 29, 2012Assignee: Branded Products for the FutureInventors: Ricardo Mayo-Alvarez, Ronny McNeil
-
Patent number: 8187583Abstract: Improved oil-in-water emulsions are provided and a method for their manufacture. In particular, the emulsions comprise a means to control delivery of oil-soluble or water-soluble actives in a core comprising a liquid oil or gel oil continuous phase, which actives can be delivered with improved deposition to surfaces such as, in particular, the skin, gastro-intestinal tract and that defined by the oral cavity. The emulsions are also noted for their improved stability.Type: GrantFiled: January 27, 2010Date of Patent: May 29, 2012Assignee: Conopco, Inc.Inventors: Nicholas David Hedges, John Turner Mitchell, Gleb Yakubov
-
Patent number: 8133881Abstract: The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.Type: GrantFiled: July 13, 2005Date of Patent: March 13, 2012Assignee: Shire LLCInventors: Travis Mickle, Thomas Piccariello, James Scott Moncrief, Nancy Johnston Boerth, Barney Bishop
-
Patent number: 7973048Abstract: A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, levorphanol, codeine, acetaminophen and combinations of these analgesics. The composition is formulated for oral administration as a liquid or solid dosage form for immediate, slow, delayed or sustained-release characteristics.Type: GrantFiled: January 26, 2010Date of Patent: July 5, 2011Assignee: Branded Products for the FutureInventors: Ricardo Mayo-Alvarez, Ronny McNeil
-
Patent number: 7854924Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.Type: GrantFiled: March 30, 2004Date of Patent: December 21, 2010Assignee: Relypsa, Inc.Inventors: Robert Alpern, Jerry Buysse, Han Ting Chang, Dominique Charmot, Michael James Cope, John Fordtran, Gerrit Klaerner, Eric Connor, Mingjun Liu, Futian Liu, Jun Shao
-
Publication number: 20100166858Abstract: A coated drug-ion exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. The drug-ion exchange resin complex is in admixture with a release retardant. The coating is a polyvinyl acetate polymer and a plasticizer. Methods of making and products containing this coated complex are described.Type: ApplicationFiled: March 12, 2010Publication date: July 1, 2010Applicant: Tris Pharma, Inc.Inventors: KETAN MEHTA, Yu-Hsing Tu
-
Publication number: 20100055066Abstract: According to the present invention, an agent for prophylactic and/or therapeutic treatment of diabetes comprising a substance inhibiting activity of farnesoid X receptor as an active ingredient can be provided.Type: ApplicationFiled: October 14, 2005Publication date: March 4, 2010Inventors: Kazuo Suzuki, Kaoru Sakai, Shinichi Ishii, Kanami Sugimoto, Johan Auwerx, Mitsuhiro Watanabe
-
Patent number: 7652026Abstract: A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, levorphanol, codeine, acetaminophen and combinations of these analgesics. The composition is formulated for oral administration as a liquid or solid dosage form for immediate, slow, delayed or sustained-release characteristics.Type: GrantFiled: February 12, 2007Date of Patent: January 26, 2010Assignee: Branded Products for the FutureInventors: Ricardo Mayo-Alvarez, Ronny McNeil
-
Patent number: 7438900Abstract: A pharmaceutical composition comprising an active agent bound to a scaffold for dendritic encapsulation wherein said scaffold is covalently or non-covalently attached to a polysaccharide. More specifically, the invention is directed to active agent complexes or conjugates which utilize dendritic encapsulation alone or in combination with other delivery systems to improve and target active agent release.Type: GrantFiled: July 8, 2004Date of Patent: October 21, 2008Assignee: Shire LLCInventors: Thomas Piccariello, Travis Mickle, Barney Bishop
-
Patent number: 7375083Abstract: The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause overdose or to be abused. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.Type: GrantFiled: September 30, 2004Date of Patent: May 20, 2008Assignee: Shire LLCInventors: Travis Mickle, Suma Krishnan, James Scott Moncrief, Christopher Lauderback, Christal Mickle
-
Patent number: 7375082Abstract: The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that release the hydrocodone following oral administration while being resistant to abuse by circuitous routes such as intravenous (“shooting”) injection and intranasal administration (“snorting”). Further, hydrocodone compositions of the invention are resistant to oral abuse as well, since release of the hydrocodone at suprapharmacological doses reaches saturation.Type: GrantFiled: September 30, 2004Date of Patent: May 20, 2008Assignee: Shire LLCInventors: Travis Mickle, Suma Krishnan, James Scott Moncrief, Christal Mickle, Christopher Lauderback, Thomas Piccariello
-
Patent number: 7192966Abstract: A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, levorphanol, codeine, acetaminophen and combinations of these analgesics. The composition is formulated for oral administration as a liquid or solid dosage form for immediate, slow, delayed or sustained-release characteristics.Type: GrantFiled: November 17, 2003Date of Patent: March 20, 2007Assignee: Branded Products for the FutureInventors: Ricardo Mayo-Alvarez, Ronny McNeil
-
Patent number: 7087223Abstract: Provided in a phosphate ion adsorbent containing a weakly basic anion exchange resin as an active ingredient which aims at providing preventives and/or remedies for hyperphosphatemia having a high selectivity for the adsorption of phosphate ion and showing an effect of lowering blood phosphorus level and another effect of suppressing phosphorus excretion into the urine.Type: GrantFiled: November 9, 2004Date of Patent: August 8, 2006Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takeshi Goto, Kazuhisa Yoshitake, Hiroshi Sorimachi, Kazuteru Moriyama
-
Patent number: 6692732Abstract: A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: December 19, 2002Date of Patent: February 17, 2004Assignee: Genzyme CorporationInventors: Richard Fitzpatrick, Chad Cori Huval, Caroline Isabelle Bacon Kurtz, W. Harry Mandeville, III, Thomas X. Neenan
-
Patent number: 6491903Abstract: Provided are methods of inhibiting bile acid uptake from the gastrointestinal system and reducing blood serum cholesterol by administering to a mammal, such as a human, an effective amount of particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain.Type: GrantFiled: June 27, 1997Date of Patent: December 10, 2002Assignee: Washington UniversityInventors: Denis Forster, Gary S. Jacob, James M. Warner
-
Patent number: 6387362Abstract: An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.Type: GrantFiled: August 14, 1998Date of Patent: May 14, 2002Assignees: Kanegafuchi Kagaku Kogyo, Kabushiki KaishaInventors: Fumiyasu Hirai, Nobutaka Tani, Takamune Yasuda, Takashi Asahi
-
Patent number: 6383500Abstract: Provided are particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain. Also provided are compositions comprising such particles, including pharmaceutical compositions, methods of making the present particles, and methods of using such particles, for example for delivery of pharmaceutically active agents.Type: GrantFiled: June 27, 1997Date of Patent: May 7, 2002Assignee: Washington UniversityInventors: Karen L. Wooley, K. Bruce Thurmond, II, Haiyong Huang
-
Publication number: 20020015687Abstract: An environmentally friendly method of loading nicotine onto cation exchange resins under anhydrous conditions is described. The method eliminates many of the processing problems that are associated with loading in aqueous media.Type: ApplicationFiled: June 20, 2001Publication date: February 7, 2002Inventors: Simon Andrew Bellamy, Lyn Hughes
-
Patent number: 6290947Abstract: A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: June 19, 2000Date of Patent: September 18, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Richard Fitzpatrick, Chad Cori Huval, Caroline Isabelle Bacon Kurtz, W. Harry Mandeville, III, Thomas X. Neenan