Polymer Derived From Ethylenic Monomers Only Patents (Class 424/78.18)
  • Patent number: 11590259
    Abstract: This invention relates generally to water-insoluble but water-swellable and deformable crosslinked PEGylated microgel particles of proteins and protein-based macromolecules that are pseudoplastic (shear thinning) and flow in aqueous media under shear and which can be injected or made to flow, wherein said microgel particles can reform as a cluster of microgel particles when shearing forces are removed. The microgel particles function as a matrix to support cell growth, viability, and proliferation.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: February 28, 2023
    Assignee: ROCHAL TECHNOLOGIES LLC
    Inventors: Joseph Charles Salamone, Ann Beal Salamone, Katelyn Elizabeth Reilly, Laura Jean Suggs, Eunna Chung, Kelly Xiaoyu-Chen Leung
  • Patent number: 11497838
    Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: November 15, 2022
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
  • Patent number: 11319301
    Abstract: The disclosed and/or claimed inventive concept(s) provides a complex of at least one halogen and a compound comprising at least one ether, thioether, and/or imine moiety and at least two lactam moieties. The disclosed and/or claimed inventive concept(s) further provides compositions comprising the complexes and applications thereof in various industrial areas including personal care, home care, pharmaceuticals, antimicrobials, disinfectants, biocides, germicides, and coatings.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: May 3, 2022
    Assignee: ISP INVESTMENTS LLC
    Inventors: Osama M. Musa, Melissa J. Goodwin, Benjamin W. Steed, Jonathan W. Steed
  • Patent number: 10639353
    Abstract: Provided are methods of producing mono- and di-pegylated IL-10.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: May 5, 2020
    Assignee: Merck Sharp & Dohme Corp
    Inventors: Steven J. Blaisdell, Collette M. Cutler, Brittany C. Paporello, Alexandre Ambrogelly
  • Patent number: 10085927
    Abstract: The present application relates to a nondetergent cosmetic composition comprising at least one alkoxysilane comprising at least one basic functional group and at least one microbial gum. The present disclosure also relates to the use, for the treatment of keratin materials, such as the hair, for example, damaged, curly, dry or fine hair, of this composition, and also to a method of hair shaping comprising the application of said composition to the hair.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: October 2, 2018
    Assignee: L'OREAL
    Inventors: Katarina Benabdillah, Patrice Lerda
  • Patent number: 10028899
    Abstract: The present disclosure is directed to alcohol-based anti-adherent compositions that do not adhere to or attract Gram-negative and Gram-positive bacteria once it is applied to a surface and dried. The composition may include as anti-adherent agents, hydrophilic film-formers such as cellulosics, gums, acrylates, nonionic polymers, and anionic polymers. Examples of anti-adherent agents include Hydroxypropyl methylcellulose, Cellulose gum, Acacia Senegal Gum; Polyacrylate Crosspolymer-11, VP/Dimethyl-aminoethylmethacrylate/Polycarbamyl Polyglycol Ester; Acrylates/Vinyl Neodecanoate Crosspolymer, hydroxypropyl methylcellulose, Hydroxypropylcellulose, Methylcellulose, Propylene Glycol Alginate, Polyacrylate Crosspolymer-6, VP/Polycarbamyl Polyglycol Ester, Acrylates/Steareth-20 Methacrylate Copolymer; Acrylates Copolymer, and any combination thereof. The anti-adherent may be applied to surfaces using a vehicle such as a wipe.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 24, 2018
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Vinod Chaudhary, Scott W. Wenzel, Kathleen C. Engelbrecht, David W. Koenig, Amy L. Vanden Heuvel, Divesh Bhatt, Paige N. Anunson, Stacy A. Mundschau
  • Patent number: 9649325
    Abstract: The present invention relates to esterified polysaccharide osmotics, use of same, processes for synthesis of same as well as compositions containing same.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: May 16, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Dominik Fenn, Thomas Fichert, Thomas Schweitzer, Ingo Bichlmaier
  • Patent number: 9421091
    Abstract: An intraocular lens insertion apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: August 23, 2016
    Assignee: Abbott Medical Optics Inc.
    Inventors: Harish Makker, Can B. Hu, Michael D. Lowery
  • Publication number: 20150071870
    Abstract: This invention pertains to a polymeric composition and an antimicrobial composition, each comprising a superabsorbent polymer (SAP), such as used in diapers and sanitary napkins, and peroxide. The superabsorbent material can be made by the process of treating a preformed SAP, such as a crosslinked polyacrylate salt, with a treatment solution comprising hydrogen peroxide dissolved in water, followed by drying. The resulting superabsorbent material has strong antimicrobial activity. Optionally, the treatment solution may also contain a metal salt, including those of zinc, zirconium, and magnesium.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 12, 2015
    Applicant: Quick-Med Technologies, Inc.
    Inventors: William Toreki, Susan Leander, Gerald M. Olderman
  • Publication number: 20150064131
    Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
    Type: Application
    Filed: September 16, 2014
    Publication date: March 5, 2015
    Applicant: Valorisation-Recherche Limited Partnership
    Inventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
  • Patent number: 8956640
    Abstract: A block copolymer comprising a methoxyethyl methacrylate (MOEMA) midblock is provided for forming a coating a medical device for controlled release of a bioactive agent.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 17, 2015
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Thierry Glauser
  • Patent number: 8945927
    Abstract: The present invention relates to a new class of cationic polymers that self-assemble with a pH-sensitive dissolution switch, and their uses to deliver molecules of interest to a cell. The present invention also relates to compositions comprising said cationic polymers non-covalently associated with a molecule of interest, in particular with a siRNA.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: February 3, 2015
    Assignees: Universite de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Guy Zuber, Benoit Frisch, Gaelle Creusat, Jean-Sebastien Thomann
  • Publication number: 20150024017
    Abstract: A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L·pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
    Type: Application
    Filed: April 11, 2014
    Publication date: January 22, 2015
    Applicant: OPLON PURE SCIENCE, LTD.
    Inventors: Shmuel BUKSHPAN, Gleb ZILBERSTEIN
  • Patent number: 8932623
    Abstract: The present invention provides a wound dressing comprising a tessellated water-soluble molding matrix comprised of a polymer selected from the group consisting of polyvinyl alcohol, gelatin, and mixtures thereof and a 1,1-disubstituted ethylene monomer. The present invention further provides methods of using the wound dressing and kits containing the wound dressing.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: January 13, 2015
    Assignee: Ethicon, Inc.
    Inventor: Scott Alan Keplinger
  • Patent number: 8920841
    Abstract: A polymer system useful for in vivo delivery of a therapeutic agent is provided. The polymer system comprises a biocompatible biodegradable polymeric backbone that is capable of a reversible stimuli-induced transition from liquid to gel.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: December 30, 2014
    Inventors: Heather Sheardown, Scott Fitzpatrick, M.A. Jafar Mazumder
  • Publication number: 20140370074
    Abstract: A method of in-situ adhering comprising providing pre-gel that comprises a mixture of at least one phenol-based compound and at least one water miscible polymer selected from at least one of a naturally existing form of a carbohydrate, a synthetically prepared form of carbohydrate and a salt of an anionic polysaccharide; spreading a layer of the pre-gel onto a first surface; adding a solid support, comprising at least one cross linking agent capable of interacting with the water miscible polymer to the pre-gel; and allowing the pre-gel to cure and adhere onto the first surface.
    Type: Application
    Filed: April 24, 2014
    Publication date: December 18, 2014
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Havazelet BIANCO-PELED, Ohad KIMHI
  • Publication number: 20140341975
    Abstract: A composition-of-matter is provided as well as pharmaceutical compositions and methods of using same. The composition of matter includes least one active moiety surrounded by a scaffold configured for enabling selective influx of an agent capable of interacting with the at least one active moiety.
    Type: Application
    Filed: August 23, 2012
    Publication date: November 20, 2014
    Applicant: VICOY NANOMEDICINES LTD
    Inventor: Erez Aharon Livneh
  • Patent number: 8883133
    Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: November 11, 2014
    Assignee: Valorisation-Recherche Limited Partnership
    Inventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
  • Patent number: 8877172
    Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: November 4, 2014
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Shaoyi Jiang, Andrew Keefe, Hong Xue
  • Publication number: 20140314703
    Abstract: The present invention relates to immunogenic complexes formed between polyanionic carbomers and Env polypeptides. Uses of the immunogenic complexes in applications including inducing an immune response and immunization generally are described. Methods of forming and manufacture of the immunogenic complexes are also described. The present invention also relates to immunogenic compositions including low viscosity, polyanionic carbomers and Env polypeptides. Uses of such immunogenic compositions in applications including inducing an immune response and immunization generally are described. Methods of manufacture of such immunogenic compositions are also described.
    Type: Application
    Filed: November 14, 2012
    Publication date: October 23, 2014
    Inventors: Susan W. Barnett, Antu Dey
  • Patent number: 8865652
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: October 21, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Martin Oft, Catherine Sheppard, John Mumm, Lingling Wu
  • Patent number: 8858924
    Abstract: Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: October 14, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Josee Roy
  • Publication number: 20140294751
    Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 2, 2014
    Applicant: CytoSorbents Corporation
    Inventors: Thomas D. Golobish, Vincent J. Capponi, David R. Clay
  • Patent number: 8840874
    Abstract: The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial cells by means of polymer-drug conjugates modified with a carbohydrate ligand for the vascular selectins. A model chemotherapeutic drug, doxorubicin, and the E-selectin ligand, sLex, are attached to a biocompatible polymer (HPMA). The selective binding, cellular uptake, intracellular fate, and cell cytotoxicity of the polymer-bound drug are investigated in human endothelial cells.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: September 23, 2014
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Ayelet David, Gonen Ashkensy, Yosi Shamay
  • Publication number: 20140255333
    Abstract: The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Applicant: University of Massachusetts Medical School
    Inventors: Jie Song, Jianwen Xu
  • Publication number: 20140242024
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
  • Publication number: 20140212372
    Abstract: Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions.
    Type: Application
    Filed: December 4, 2013
    Publication date: July 31, 2014
    Applicant: E I DU PONT DE DEMOURS AND COMPANY
    Inventors: MARK ALLEN ANDREWS, Garret D. Figuly, Henry Keith Chenault
  • Patent number: 8784792
    Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: July 22, 2014
    Assignee: Valorization-Recherche Limited Partnership
    Inventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
  • Patent number: 8753619
    Abstract: Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: June 17, 2014
    Assignee: Covidien LP
    Inventors: Ahmad R. Hadba, Joshua B. Stopek
  • Patent number: 8753620
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: June 17, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Publication number: 20140134111
    Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
    Type: Application
    Filed: January 20, 2014
    Publication date: May 15, 2014
    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: RONIT SATCHI-FAINARO, KEREN MILLER, DORON SHABAT, ROTEM EREZ
  • Patent number: 8715635
    Abstract: A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: May 6, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Ehud Keinan
  • Patent number: 8715708
    Abstract: A novel class of Cylic Acetal biomaterials (CABs) based on a cyclic acetal unit is disclosed and claimed by Applicants. Two novel biomaterials suitable for use in a variety of biological applications including in the orthopedic field for joint and cartilage replacement and/or repair, and bone cement. The biomaterials are comprised of either a network of monomers of 5-ethyl-5-(hydroxymethyl)-?,?-dimethyl-1,3-dioxane-2-ethanol diacrylate (EHD) and a hydrogel comprised of EHD and poly(ethylene glycol) diacrylate (PEG-EHD).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: May 6, 2014
    Assignee: University of Maryland
    Inventors: John Patrick Fisher, Sachiko Kaihara, Jennifer Lynn Moreau, Parth Modi
  • Patent number: 8709395
    Abstract: A method for repairing or replacing damaged tissue, or for providing post-surgical augmentation, comprising administering a pliable biocompatible material and a physiologically acceptable suspending agent to a patient is disclosed. Copolymers of unsubstituted acrylate and substituted acrylate are disclosed as pliable biocompatible materials.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: April 29, 2014
    Inventor: Ayman Boutros
  • Patent number: 8703116
    Abstract: The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 22, 2014
    Assignee: Starpharma Pty Limited
    Inventors: Benjamin James Boyd, Lisa Michelle Kaminskas, Christopher John Hamilton Porter, Peter Karellas, Guy Yeoman Krippner, Pasquale Razzino, Brian Devlin Kelly, Zemin Wu, Sue Pallich
  • Patent number: 8703113
    Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: April 22, 2014
    Assignee: REVA Medical Inc.
    Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
  • Patent number: 8691205
    Abstract: Provided are methods of producing a mixture of mono- and di-pegylated IL-10.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: April 8, 2014
    Assignee: Merck Sharp & Dohme Corporation
    Inventors: Steven J. Blaisdell, Collette M. Cutler, Brittany C. Paporello, Alexandre Ambrogelly
  • Publication number: 20140088669
    Abstract: Particles and related methods are disclosed.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 27, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Janel L. Lanphere, John Spiridigliozzi, Orla McCullagh, Paul D. DiCarlo
  • Publication number: 20140072513
    Abstract: The present invention relates to degradable polyacetal polymers having a C(O)—(CH2CH2O)n—R5 or a saccharide attached to amine radical of the backbone of the polymer, their polymer-active agent conjugates and their preparation processes, to compositions, and hydrogels containing them, as well as their use in therapy, diagnostic imaging and cosmetics.
    Type: Application
    Filed: April 3, 2012
    Publication date: March 13, 2014
    Inventor: Oscar Peña Gulin
  • Patent number: 8652484
    Abstract: The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct; b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: February 18, 2014
    Assignee: Immunomedics, Inc.
    Inventors: William J. McBride, Christopher A. D'Souza, Chien-Hsing Chang, David M. Goldenberg
  • Patent number: 8642024
    Abstract: Provided herein is an anhydrous cosmetic composition comprising at least one organic structuring agent, at least one modified starch, at least one wood meal, at least one surfactant, and at least one anhydrous liquid phase. Also provided is a method for cleansing and/or conditioning keratin materials, comprising applying at least one of the anhydrous cosmetic compositions to the keratin materials.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: February 4, 2014
    Assignee: L'Oreal
    Inventors: Céline Sellier, Gérard Gabin
  • Patent number: 8623413
    Abstract: The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: January 7, 2014
    Assignee: Ethicon, Inc.
    Inventors: Aruna Nathan, Joel Rosenblatt, Steven C. Arnold
  • Publication number: 20130323319
    Abstract: The current invention involves the surprising finding that when carboxylated particles, such as carboxylated polystyrene, PLGA, or diamond particles are administered to subjects, inflammatory immune responses are ameliorated. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same carboxylated particles.
    Type: Application
    Filed: November 14, 2011
    Publication date: December 5, 2013
    Applicant: GETTS CONSULTING AND PROJECT MANAGEMENT
    Inventors: Daniel R. Getts, Rachael Terry, Nicholas King
  • Publication number: 20130294926
    Abstract: An antifouling film is coated on a base, and contains a binder component, conductive particles, and a fluororesin. The conductive particles are bound together by the binder component; the binder component is closely bound to the base; and the antifouling film has a comprising the conductive particles of which surfaces are covered with the fluororesin.
    Type: Application
    Filed: March 5, 2012
    Publication date: November 7, 2013
    Applicant: PANASONIC CORPORATION
    Inventor: Ryou Katou
  • Patent number: 8574604
    Abstract: The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 5, 2013
    Assignee: Interface Biologics, Inc.
    Inventors: Roseita Esfand, Paul J. Santerre, Meilin Yang
  • Patent number: 8574465
    Abstract: The present invention relates to organic polymeric photon up-conversion nanoparticles for biological applications, such as labeling and/or detection of cells, biological (macro-) molecules or other analytes, as well as for sensing temperature, pressure, oxygen and other substances that influence the up-conversion process. It further relates to organic photon up-conversion nanoparticles for singlet oxygen generation and the treatment of diseases, such as cancer.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: November 5, 2013
    Assignee: Sony Corporation
    Inventors: Tzenka Miteva, Gerda Fuhrmann, Gabriele Nelles, Vladimir Yakutkin, Stanislav Balouchev
  • Publication number: 20130287688
    Abstract: Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., a cancer therapy) are disclosed. In one embodiment, methods and compositions for treating or preventing a cancer (e.g., a solid tumor such as a desmoplastic tumor) by administering to a subject an anti-hypertensive agent, as a single agent or in combination with a microenvironment modulator and/or a therapy, e.g., a cancer therapy (for example, a therapeutic agent or therapy, including immunotherapy (e.g., antibodies, vaccine, cell-based), nanotherapeutics, radiation therapy, photodynamic therapy, low molecular weight chemotherapeutics, molecularly targeted therapeutics and/or oxygen radical) are disclosed.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 31, 2013
    Applicants: XTUIT PHARMACEUTICALS, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: The General Hospital Corporation, Xtuit Pharmaceuticals, Inc.
  • Patent number: 8541013
    Abstract: The invention is directed to a copolymer comprising at least three types of monomeric units, said three types of monomeric units comprising: a temperature-sensitive unit, a hydrophilic unit, and a hydrophobic unit comprising at least one pH-sensitive moiety; wherein said hydrophobic monomeric unit is derived from a copolymerizable unsaturated fatty acid.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: September 24, 2013
    Assignee: Agency for Science, Technology and Research
    Inventors: Yi Yan Yang, Kumaresh Soppimath
  • Patent number: 8541020
    Abstract: The invention aims at providing a polymeric hydrogel which is highly resistant to water washing. The aim is attained by a polymeric hydrogel comprising a polymeric matrix formed by copolymerizing a nonionic polymerizable monomer with a crosslinking monomer, characterized in that the polymeric matrix contains a wetting agent and water, at least 50 wt % of the wetting agent is constituted of a polymer prepared by polymerizing a polyhydric alcohol monomer component containing a trihydric or more alcohol monomer, and the polymer is a water-soluble one which has an average molecular weight of 150 to 4000 and satisfies the relationship: {(number of ether groups in the polymer+number of hydroxyl groups in the polymer)/number of carbon atoms present in the polymer}?1/3.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: September 24, 2013
    Assignee: Seikisui Plastics Co., Ltd.
    Inventors: Shuichi Sasahara, Kazuhiro Yosikawa, Shinichi Wakamatsu, Takahiko Fujita
  • Publication number: 20130243862
    Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 19, 2013
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams