Nitroxide Or Nitroxide Containing Patents (Class 424/9.33)
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Patent number: 11111225Abstract: A compound useful as a release agent, and a release agent, a curable composition, and a nanoimprint lithography resin material each containing the compound are provided. More specifically, a calixarene compound with a molecular structure represented by the following structural formula (1) and a composition containing the calixarene compound are provided. wherein R1 denotes a structural moiety with a perfluoroalkyl group, R2 denotes a hydrogen atom, a polar group, a polymerizable group, or a structural moiety with a polar group or a polymerizable group, R3 denotes a hydrogen atom, an aliphatic hydrocarbon group that may have a substituent, or an aryl group that may have a substituent, n denotes an integer in the range of 2 to 10, and * denotes a bonding point with an aromatic ring.Type: GrantFiled: November 16, 2017Date of Patent: September 7, 2021Assignee: DIC CorporationInventors: Shinya Yamamoto, Masanori Miyamoto, Tomoyuki Imada
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Patent number: 10202342Abstract: The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.Type: GrantFiled: December 22, 2010Date of Patent: February 12, 2019Assignee: University of Maryland, BaltimoreInventors: Joseph P. Y. Kao, Scott R. Burks, Gerald R. Rosen
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Patent number: 9447157Abstract: Nitration shielding peptides that reduce or prevent nitration of a protein of interest are disclosed. The peptide can serve as molecular sink for nitrating agents, block access of the nitrating agents to the target tyrosine on the protein of interest, serve as substrate for the nitrating agent (i.e., provide an alternative nitratable tyrosine residue), provide a nitrating agent neutralizing moiety such as antioxidant, or a combination thereof. The nitration shielding peptide can be a fusion protein that includes one or more additional domains such a protein transduction domain, a targeting signal, a purification tag, or any combination thereof. Exemplary nitration shielding peptides for reducing nitration of RhoA and PKG-1?, and methods of use thereof for treating pathologies, disease, and disorders associated with nitration of RhoA and PKG-1?, respectively are also provided.Type: GrantFiled: September 15, 2014Date of Patent: September 20, 2016Assignee: Augusta University Research Institute, Inc.Inventors: Stephen M. Black, Ruslan Robertovich Rafitov
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Patent number: 8715621Abstract: The present invention provides a variety of radicals, which are useful as polarizing compounds. Exemplary radicals are represented by compounds of Structural Formulae (I), (II), (III) and (IV) as described herein.Type: GrantFiled: March 15, 2012Date of Patent: May 6, 2014Assignee: Massachusetts Institute of TechnologyInventors: Timothy Manning Swager, Robert Guy Griffin, Olesya Haze, Bjorn Corzilius, Albert A. Smith
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Patent number: 8487079Abstract: Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group covalently linked to a mitochondria-targeting group derived from a hemigramicidin moiety. The mitochondria-targeted electron scavenger can be used to treat medical conditions associated with acute or chronic inflammation.Type: GrantFiled: August 8, 2008Date of Patent: July 16, 2013Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Mitchell P. Fink, Peter Wipf
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Publication number: 20130142735Abstract: A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.Type: ApplicationFiled: January 31, 2013Publication date: June 6, 2013Inventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Marie Schmainda, Douglas Edward Prah, Marcos Lopez, Micael Joel Hardy
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Patent number: 8388936Abstract: A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.Type: GrantFiled: February 23, 2009Date of Patent: March 5, 2013Assignee: MCW Research Foundation, Inc.Inventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Marie Schmainda, Douglas Edward Prah, Marcos Lopez, Micael J. Hardy
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Patent number: 7994258Abstract: There is provided a hyperbranched polymer having a nitroxyl group. A hyperbranched polymer comprising at least one organic radical structure (nitroxyl group) of Formula (1), Formula (2) or Formula (3): and having a weight average molecular weight measured by gel permeation chromatography in a converted molecular weight as polystyrene of 500 to 5,000,000.Type: GrantFiled: October 23, 2008Date of Patent: August 9, 2011Assignees: Nissan Chemical Industries, Ltd., Kyushu UniversityInventors: Noboru Koga, Satoru Karasawa, Hiroyuki Hayashi, Akihiro Tanaka, Keisuke Odoi
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Publication number: 20110165087Abstract: The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.Type: ApplicationFiled: December 22, 2010Publication date: July 7, 2011Inventors: JOSEPH P.Y. KAO, SCOTT R. BURKS, GERALD R. ROSEN
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Publication number: 20110050228Abstract: An agent for magnetic resonance studies, the agent comprising hyperpolarized 15N labelled N2O in solution or liquid 15N—N2O.Type: ApplicationFiled: March 10, 2009Publication date: March 3, 2011Applicant: University of SouhamptonInventors: Malcolm Harris Levitt, Giuseppe Pileio
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Publication number: 20100310471Abstract: The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitroxide derivatives are useful as therapeutic or diagnostic agents. This invention further concerns novel methods for the production of the heparin-nitroxide agents, and methods of their uses for specifically targeting and labelling of biological vessels. The inventions also suggest the uses of the heparin-nitroxide derivatives for treatment of oxidative stress-mediated diseases. Furthermore, the heparin-nitroxide derivatives according to the present invention are in particular useful for electron paramagnetic resonance imaging (EPRI), for magnetic resonance imaging (MRI), and for preservation of biological transplants.Type: ApplicationFiled: August 22, 2008Publication date: December 9, 2010Applicant: Johannes Gutenberg-Universität MainzInventors: Andrey Kleschyov, Thomas Munzel, Valery Golubev, Vasily Sen
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Publication number: 20100260684Abstract: The present invention provides for lipophilic, labile alkanoyloxymethyl esters of nitroxides that cross the blood-brain barrier, and after hydrolysis with esterases therein, the corresponding anionic nitroxides are intracellularly entrapped at levels sufficient to permit O2 measurements by electron paramagnetic resonance spectroscopy.Type: ApplicationFiled: June 2, 2008Publication date: October 14, 2010Inventors: Joseph P.Y. Kao, Gerard M. Rosen, Ke-Jian Liu
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Publication number: 20090214437Abstract: A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.Type: ApplicationFiled: February 23, 2009Publication date: August 27, 2009Applicant: Medical College of Wisconsin Research FoundationInventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Marie Schmainda, Douglas Edward Prah, Marcos Lopez, Micael J. Hardy
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Publication number: 20090028798Abstract: Disclosed is a method for determining the redox status of a region of interest in an animal tissue. The method includes administering a nitroxyl contrast agent to the region of interest, obtaining a magnetic resonance image of the region of interest, determining the amount of reduced nitroxyl contrast agent in the region of interest, and thereby determining the redox status of the region of interest.Type: ApplicationFiled: August 10, 2006Publication date: January 29, 2009Applicant: Government of the USA, represented by the Secretary, Dept.of Health and Human ServicesInventors: James B. Mitchell, Murali K. Cherukuri, John A. Cook, Fuminori Hyodo, Alan P. Koretsky, Ken-Ichiro Matsumoto, Sankaran Subramanian, David A. Wink
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Publication number: 20080138292Abstract: The present invention generally relates to agents and compositions having MRI and/or optical signals, and methods for their use in the determination of an analyte. In some cases, an optical, MRI, or other signal produced by the agent or composition may be affected by the presence of an analyte. Some embodiments of the present invention may provide agents or compositions which are cell permeable. Examples of analytes that may be determined by the present invention include zinc ions, calcium ions, and other biological analytes.Type: ApplicationFiled: September 14, 2007Publication date: June 12, 2008Applicant: Massachusetts Institute of TechnologyInventors: Xiao-An Zhang, Alan Pradip Jasanoff, Stephen J. Lippard
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Patent number: 7351402Abstract: We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two paramagnetic centers. In a preferred embodiment, the polarizing agent comprises two nitroxide radicals tethered by a polyethylene glycol chain of variable length. Signal enhancements of up to 175 have been achieved in comparison with factors of ˜45 at similar concentrations of monomeric radical such as TEMPO.Type: GrantFiled: August 18, 2004Date of Patent: April 1, 2008Assignee: Massachusetts Institute of TechnologyInventors: Robert G. Griffin, Kan-Nian Hu
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Patent number: 7108846Abstract: The present invention relates to chemical synthesis of radiolabelled perfluorinated bioactive compounds. More particularly, the present invention relates to radiolabelled compounds to be used as indicators for tissue hypoxia. More particularly, the present invention relates to the synthesis and the use of [18F] labelled perfluorinated nitroimidazole compounds having an incorporation of [18F] atoms characterized by a specific radioactivity of the compound comprised between 1 and 30 Ci/mmol, preferably between 1 and 20 Ci/mmol, preferably 1 and 10 Ci/mmol. More particularly to [18F] labelled EF3 or [18F] labelled EF5. The present invention also relates to a method for the detection of tissue hypoxia in a patient comprising introducing an [18F] labelled nitroimidazole compound into said patient, imaging tissue hypoxia in said patient, and, quantifying tissue hypoxia in said patient.Type: GrantFiled: May 22, 2000Date of Patent: September 19, 2006Assignee: Universite Catholique De LouvanInventors: Jacqueline Marchand, Vincent Gregoire
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Patent number: 7097825Abstract: Method for obtaining BOLD MRI images with allosteric effector compounds are disclosed. Methods for the determination of tumor oxygenation and for an optimal time for initiating radiation therapy are also disclosed.Type: GrantFiled: February 25, 2002Date of Patent: August 29, 2006Assignee: Allos Therapeutics, Inc.Inventor: Michael Gerber
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Patent number: 6991778Abstract: The image obtained by MR imaging of the joint of an animal, including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized dendrimer containing at least 6 nitroxyl terminal functional groups, e.Type: GrantFiled: December 6, 2000Date of Patent: January 31, 2006Assignee: NitrosciInventor: Gerald M. Rosen
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Patent number: 6632975Abstract: The present invention provides a method for producing an in vivo model of hepatocellular carcinoma without lung metastasis in an animal by injecting diethylnitrosamine and administering nitrosomorpholine in the drinking water of the animal, as well as, methods of identifying an antimetstatic agent using the in vivo model.Type: GrantFiled: October 10, 2000Date of Patent: October 14, 2003Assignee: Kabushiki Kaisha Daiyu-Kai Institute of Medical ScienceInventors: Tomoyuki Shirai, Mitsuru Futakuchi
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Patent number: 6569688Abstract: Intravascular apparatus and method for locally treating a patient's blood vessel, are provided. The apparatus includes an implanted carrier (2) for insertion into the vessel; and a biologically active agent (8) immobilized to the carrier (2), said biologically active agent (8) reacting with a first substance to produce a second substance. The second substance is preferably a therapeutic agent, such as nitric oxide, for locally treating the vessel. The biologically active agent (8) is preferably an enzyme such as nitrogen oxide synthase, and the first substance is preferably arginine introduced to the patient's body as part of a diet. According to another embodiment, the biologically active agent (8) is a catalytic antibody and the first substance is a prodrug. Alternatively, the biologically active agent (8) is a ribozyme.Type: GrantFiled: February 28, 2000Date of Patent: May 27, 2003Assignee: Technion Research & Development Foundation Ltd.Inventors: Sarit Sivan, Uri Dinnar, Noah Lotan
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Patent number: 6315981Abstract: Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.Type: GrantFiled: March 19, 1999Date of Patent: November 13, 2001Assignee: Imarx Therapeutics, Inc.Inventor: Evan C. Unger