Magnetic Imaging Agent (e.g., Nmr, Mri, Mrs, Etc.) Patents (Class 424/9.3)
  • Patent number: 11154212
    Abstract: Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of a tissue are estimated by comparing medical images of the subject to a trained model that relates histological features to multiple different medical image contrast types, whether from one medical imaging modality or multiple different medical imaging modalities. In general, the trained model is generated based on medical images of ex vivo samples, in vitro samples, in vivo samples or combinations thereof, and is based on histological features extracted from those samples. A machine learning algorithm, or other suitable learning algorithm, is used to generate the trained model. The trained model is not patient-specific and thus, once generated, can be applied to any number of different individual subjects.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 26, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventor: Peter Sherman Laviolette
  • Patent number: 11103678
    Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: August 31, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Paul Smith, Robert B. DeVries, Jason Weiner, Man Minh Nguyen, Gary J. Leanna, Kevin John Wilcox, Javier Palomar-Moreno, Fergal Horgan, Martyn G. Folan, Patricia Kelly, Michael G. Hayes, Sean P. Fleury
  • Patent number: 11083692
    Abstract: A method to quickly adjust the size of micelles and then return the micelles to a persistent state is provided. Specifically, the present invention is directed to a method for block copolymer micelle growth under high-?N solution conditions where ultrasonic cavitation facilitates rapid solution-gas interface production that accelerates micelle growth by an order of magnitude over other methods such as vortexing. The persistent micelles formed by the method of the present invention can then be used for controlled delivery of dispersions in organic electronic coatings, paint, or drug delivery applications and can also be used to control the pore size of films that include an oxide, a nitride, a carbide, a metal, or a carbon material.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: August 10, 2021
    Assignee: University of South Carolina
    Inventors: Morgan Stefik, Hasala N. Lokupitiya
  • Patent number: 11059836
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: July 13, 2021
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Samuel Coe, Peter David Johnson, Michael Edward Prime, Christopher John Brown, Sébastien René Gabriel Galan, Paul Richard Giles, Jonathan Bard, Elise Luciennen Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, John Wityak, Alex Kiselyov, Sarah Hayes
  • Patent number: 11014804
    Abstract: Systems and methods for fabricating 3D soft microstructures. The system comprises injecting a pressurized, curable liquid into certain structural layers induces folding and allows the 2D structures to reconfigure into a 3D form In addition to the injection of a curable liquid that permanently reconfigures the structure of the system, in an embodiment this method also allows for the injection of other liquids into certain actuator layers that enable motion in certain portions of the system Furthermore, the system allows for handling of colored fluids that are passed to visualization layers. The method of creating such a system depends on taking advantage of laser machining of the individual layers to influence the behavior of how different portions bend and move.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 25, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Nicholas W. Bartlett, Tommaso Ranzani, Sheila Russo, Conor J. Walsh, Michael Wehner, Robert J. Wood
  • Patent number: 11016152
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 25, 2021
    Assignees: Vanderbilt University, Duke University, The Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Patent number: 10942237
    Abstract: A system for hyperpolarizing a substance is provided. The system includes a cryostat and a polarizer. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals. Once the substance is polarized, the radicals contained within the substance are quenched by adjusting a temperature of the substance to greater than or equal to a melting point of the substance. In embodiments, the polarizer may then rapidly freeze the substance.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: March 9, 2021
    Assignee: GE Precision Healthcare LLC
    Inventors: Arnaud Comment, Albert Chen
  • Patent number: 10905783
    Abstract: Provided are formulations including a contrast agent selected from glucosamine, a salt thereof and a glucosamine derivative, for use in imaging.
    Type: Grant
    Filed: November 27, 2016
    Date of Patent: February 2, 2021
    Inventors: Michal Rivlin, Gil Navon
  • Patent number: 10895620
    Abstract: Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood cells (RBC) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129Xe MRI RBC image.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: January 19, 2021
    Assignee: Duke University
    Inventors: Bastiaan Driehuys, Gary Price Cofer
  • Patent number: 10895619
    Abstract: The invention relates to a method of Dixon-type MR imaging. It is an object of the invention to provide a method that enables Dixon water/fat separation with high SNR and with improved noise propagation in the water/fat separation.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: January 19, 2021
    Assignee: Koninklijke Philips N.V.
    Inventor: Holger Eggers
  • Patent number: 10892433
    Abstract: Disclosed is a quantum dot light emitting device including a ligand-substituted quantum dot light emitting layer with a polymer having amine groups. The introduction of the ligand-substituted quantum dot light emitting layer with a polymer having amine groups changes the energy level of an electron transport layer and enables control over the charge injection properties of the device so that the flow of electrons can be controlled. In addition, the ligand substitution is effective in removing oleic acid as a stabilizer of quantum dots to prevent an increase in driving voltage caused by the introduction of the additional material, achieving markedly improved efficiency of the device. Also disclosed is a method for fabricating the quantum dot light emitting device.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: January 12, 2021
    Assignees: Korea University Research and Business Foundation, Korea Institute of Science and Technology
    Inventors: Jinhan Cho, Wan Ki Bae, Ikjun Cho
  • Patent number: 10852378
    Abstract: A method of predetermining the time profile of a contrast agent concentration at a vessel position is provided in the context of contrast agent-enhanced MRI of a region of interest only during the initial flooding-in phase of the contrast agent into the vessel situated in the region of interest. The method includes establishing a broadening of a contrast agent bolus profile according to the equation ?W=W2?W1 wherein W1 is a first width of the contrast agent bolus profile at a first vessel position and W2 is a second width of a contrast agent concentration profile at a second vessel position within the region of interest. The broadening is established by determining at least one flow parameter which is dependent on at least one blood flow property of the patient at a third vessel position thereof and which correlates with the broadening of the contrast agent profile.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: December 1, 2020
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Martin Rohrer, Gregor Jost, Hubertus Pietsch, Claus-Peter Reisinger, Harald Kramer
  • Patent number: 10806797
    Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon agonist linker conjugate Z-L1-L2-L-Y—R20, wherein Y represents an GLP-1/Glucagon agonist moiety; and -L is a linker moiety—by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon agonist.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: October 20, 2020
    Assignee: SANOFI
    Inventors: Dieter Kadereit, Michael Wagner, Thomas Olpp, Nino Meyer, Pradeep Dhal, Paul Konowicz, Robert Miller, James Stefano, Magnus Besev, Martin Bossart, Katrin Lorenz, Torsten Haack, Andreas Evers
  • Patent number: 10806826
    Abstract: A bone graft substitute for use in orthopedic bone grafting procedures comprising a radiolucent bone graft substitute combined with a temporary radiopaque agent. Methods of making and using the composition are also disclosed. Bone graft substitutes have become an effective means of regenerating bone in orthopedic procedures where bone loss results from surgically created defects or traumatic injury to the bone. Bone graft substitutes include mineral-based materials such as hydroxyapatite, calcium phosphates, and calcium phosphosilicates as well as allograft-derived materials and xenograft-derived materials such as collagen-based matrices and demineralized bone matrices.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: October 20, 2020
    Assignee: BACTERIN INTERNATIONAL, INC.
    Inventors: Helena Lovick, Gregory Juda, Todd Meyer
  • Patent number: 10793533
    Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: October 6, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
  • Patent number: 10780058
    Abstract: The present disclosure provides multifunctional nanoparticles. More particularly, the present disclosure relates to multifunctional nanoparticles having one or more of nucleic acid ligands; and methods of using such nanoparticles for treatment and/or diagnosis of diseases and conditions.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: September 22, 2020
    Assignee: University of Connecticut
    Inventors: Jessica Lynn Rouge, Joseph Awino
  • Patent number: 10729643
    Abstract: There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: August 4, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Irving H. Zucker, Hanjun Wang
  • Patent number: 10695447
    Abstract: Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an MRI image-enhancing amount; and then generating, by MRI of the subject, an image of the body or body region. The ascorbate or pharmaceutically acceptable salt thereof enhances the MRI image.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: June 30, 2020
    Assignee: Duke University
    Inventor: Christopher David Lascola
  • Patent number: 10667718
    Abstract: Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a tissue in the object as a result of comparing acquired signals to reference signals. Example embodiments facilitate distinguishing prostate cancer tissue from normal peripheral zone tissue based on quantitative data acquired using NMR fingerprinting in combination with apparent diffusion co-efficient (ADC) values or perfusion values acquired using DWI-MRI or DCE-MRI.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 2, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Mark Griswold, Vikas Gulani, Chaitra Badve, Yun Jiang
  • Patent number: 10662164
    Abstract: The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. For example, 5-(1H-indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. Antibiotic 75b antibiotic is bactericidal and is orally bioavailable. This class of antibiotics can be used as a therapeutic agent against infections by Gram-positive bacteria such as MRSA.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: May 26, 2020
    Assignee: University of Notre Dame du Lac
    Inventors: Mayland Chang, Shahriar Mobashery, Edward Spink, Derong Ding, Sebastian Testero, Erika Leemans, Marc Boudreau
  • Patent number: 10578251
    Abstract: Methods and systems are provided for a sealing system for a dynamic nuclear polarization (DNP) system. In one embodiment, a system comprises: a reservoir including an inlet opening; an outer tube; and a tapered seal shaped to seal against the inlet opening and the outer tube, the tapered seal including: a first section removably coupleable to a second section; a through-hole formed by a first plurality of inner surfaces of both the first section and the second section, the through-hole shaped to encircle the outer tube; and a vacuum channel extending through, from an outer surface to an inner surface of the first plurality of inner surfaces, one of the first section and second section. In this way, the tapered seal may be coupled around the fluid passage without inserting a tip of the fluid passage through the through-hole of the tapered seal, thereby maintaining a sterility of the system.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: March 3, 2020
    Assignee: General Electric Healthcare
    Inventors: Ernst Wolfgang Stautner, Jonathan Alan Murray, Patrick Lively Padgett
  • Patent number: 10517491
    Abstract: 3D cine MR angiography systems and methods are disclosed for use during the steady state intravascular distribution phase of ferumoxytol. The 3D cine MRA technique enables improved delineation of cardiac anatomy in pediatric patients undergoing cardiovascular MRI.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: December 31, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: J. Paul Finn, Peng Hu, Fei Han
  • Patent number: 10479802
    Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: November 19, 2019
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Samuel Coe, Jonathan Bard, Peter David Johnson, Michael Edward Prime, Christopher John Brown, Sébastien René Gabriel Galan, Paul Richard Giles, Elise Luciennen Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, John Wityak, Alex Kiselyov, Sarah Hayes
  • Patent number: 10369110
    Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 6, 2019
    Assignees: BioSpecifics Technologies Corporation, Duke University
    Inventors: Phyllis Carolyn Leppert, Thomas L. Wegman
  • Patent number: 10370391
    Abstract: The present invention includes 4-(hydroxymethyl)phenylboronic esters, which react with hydrogen peroxide to form 4-hydroxybenzyl alcohol, which is an anti-inflammatory and/or anti-oxidant compound, as well as microparticles and compositions thereof. In certain embodiments, the compositions of the invention may be used to treat or prevent oxidative stress and/or inflammation, including ischemic disease.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: August 6, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Chonbuk National University Industrial Cooperation Foundation
    Inventors: Peter M. Kang, Dongwon Lee, Seunggyu Park, Dahee Jeong
  • Patent number: 10365342
    Abstract: A method for determining a change over time in a biomarker in a region to be examined of a patient is provided. The change is determined from magnetic resonance data using a magnetic resonance measuring system with sequences and protocols for measuring the biomarkers by functional resting state connectivity by rsfMRI, perfusion values, magnetic resonance spectra of voxels, or morphometry of organs. A control unit has programs which evaluates the biomarker and a data memory which stores the results of the evaluation and additional data. During a first examination, a quantity result of the biomarkers is determined and stored in the data memory. During a follow-up examination, at least one previous item of the result and additional data from the first examination stored in the data memory are used for determining a quantitative change in the biomarker.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: July 30, 2019
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Björn Heismann, Arne Hengerer, Sebastian Schmidt
  • Patent number: 10344100
    Abstract: Hydrogel nanoparticles and microparticles are prepared by a water-in-oil method from natural polymers that are water miscible, a hydrophobic polyol and a crosslinking agent. The hydrogel nanoparticles are auto fluorescent and can be used for imaging of cells and a biological entity. The hydrogel nanoparticles and microparticles can include magnetic nanoparticles and carry desired bioactive entities. The hydrogel nanoparticles and microparticles are useful for diagnostics and as therapeutics purposes including drug delivery, imaging of drug migration, and selectivity by the tagging or binding of the hydrogel nanoparticles and microparticles with appropriate antibodies or antigens.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: July 9, 2019
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Arti Vashist, Ajeet Kaushik, Madhavan Nair
  • Patent number: 10261151
    Abstract: Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood cells (RBC) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129Xe MRI RBC image.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 16, 2019
    Assignee: Duke University
    Inventors: Bastiaan Driehuys, Gary Price Cofer
  • Patent number: 10245330
    Abstract: The present disclosure provides compositions for in vivo imaging of hydrogen peroxide; and methods for detecting hydrogen peroxide in vivo. The compositions and methods find use in various diagnostic applications, which are also provided.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: April 2, 2019
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Alexander R. Lippert
  • Patent number: 10226533
    Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: March 12, 2019
    Assignee: MicroVention, Inc.
    Inventors: Gregory M. Cruise, Clayton G. Harris, Michael J. Constant
  • Patent number: 10201789
    Abstract: To provide a dispersing device that carries out an appropriate dispersion having a good yield, processing within an appropriate temperature range, and having a high power to disperse. The dispersing device disperses a mixture that is slurry or a liquid by causing the mixture to flow between a rotor and a stator toward the outer circumference by centrifugal force. It comprises a container, a cover assembly that closes an upper opening of the container, a stator that is fixed under the cover assembly, a rotor that is disposed to face the lower surface of the stator, a rotary shaft that rotates the rotor, a bearing that is located above the stator, and a spacer that is detachably disposed between the rotary shaft and the rotor to adjust a gap between the rotor and the stator.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: February 12, 2019
    Assignee: SINTOKOGIO, LTD.
    Inventors: Yuu Ishida, Yutaka Hagata
  • Patent number: 10174361
    Abstract: The present invention is directed to methods of isolating particles, such as nucleic acid-containing particles or microvesicles, from a biological sample and extracting nucleic acids therefrom, wherein the biological sample is cerebrospinal fluid. The present invention further provides methods for aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker associated with a disease or medical condition thereof.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: January 8, 2019
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Leileata Russo
  • Patent number: 10124076
    Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: November 13, 2018
    Assignee: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventors: Brian D. Ross, Pratip Bhattacharya
  • Patent number: 10124090
    Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: November 13, 2018
    Assignee: Terumo Corporation
    Inventors: Michael Constant, Edward Michael Keeley, Joshua Garretson, Gregory M. Cruise, Wendy Graczyk
  • Patent number: 10086093
    Abstract: Disclosed herein is a nanosensor of miRNA activity in a target cell, and methods of use, for detection and diagnostic applications. The nanosensor comprises a delivery particle comprising an iron oxide crystal coated with a polymer; and a sensor oligonucleotide covalently attached to the polymer. The sensor oligonucleotide comprises a seed region, comprising a nucleic acid sequence that is completely complementary to the target miRNA and comprises a cleavage site which can be engaged and cleaved by the target miRNA.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: October 2, 2018
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Anna V. Moore, Zdravka Medarova
  • Patent number: 10080910
    Abstract: A radiation therapy system (1) includes an ultrasound (US) imaging unit (2), a registration unit (30), an US motion unit (44), and a real-time dose computation engine (46). The ultrasound (US) imaging unit (2) generates a baseline and real-time US images (3) of a subject body (4) region including a target and one or more Organs At Risk (OARs). The registration unit (30) deformably registers a planning image (32) and the baseline US image (36), and maps (66) radiation absorptive properties of tissue in the planning image (32) to the baseline US image (36). The US motion unit (44) measures motion of the target volume and OARs during radiation therapy treatment based on the real-time US images. The real-time dose computation engine (46) computes a real-time radiation dose delivered to the tissues based on the tissue radiation absorptive properties mapped from the baseline or planning images to the real-time 3D US images (3).
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: September 25, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Shyam Bharat, Vijay Parthasarathy, Ameet Kumar Jain
  • Patent number: 10072125
    Abstract: The present invention discloses thiourea-containing dendrimers and thiourea-containing hyperbranched polymers, and respectively a preparation method for the thiourea-containing dendrimer and a preparation method for the thiourea-containing hyperbranched polymer, and a thiourea-containing dendrimer and a thiourea-containing hyperbranched polymer having increased water solubility prepared by using the thiourea-containing dendrimer and the thiourea-containing hyperbranched polymer as raw materials. Finally, disclosed are applications of the thiourea-containing dendrimers and the thiourea-containing hyperbranched polymers in the preparation of antitumor and antimicrobial drugs. The thiourea-containing dendrimer and the thiourea-containing hyperbranched polymer have a significant growth inhibitive effect on solid tumors and low toxicity to normal tissues, and thus can be used for preparing drugs for treating malignant tumors.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: September 11, 2018
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Youqing Shen, Shiqun Shao, Jianbin Tang, Xiangrui Liu
  • Patent number: 10065033
    Abstract: A system and method for regulating water metabolism of cells, which comprises an energy wave generator has an energy wave's frequency control mode. The energy wave's frequency control mode includes multiple controls for acting the energy wave generator to generate and emit energy waves each with a corresponding energy density. The energy density is calculated by a corresponding base frequency, a sweep bandwidth of the corresponding base frequency, an emission rate and a total time of emission in a duty cycle, so that the energy waves with the corresponding energy densities effecting on the body of animals or human to regulate water metabolism of cells of animals or human.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: September 4, 2018
    Assignee: Taiwan Resonant Waves Research Corp.
    Inventor: Wen-Chieh Chang
  • Patent number: 10023651
    Abstract: Provided are humanized monoclonal antibodies (mAbs) or fragments thereof that bind with specificity to the Thomsen-Friedenreich (TF) human tumor antigen. Three distinct variable heavy and three variable light chains are provided, and can be combined to make a total of twenty-five distinct heavy and light chain combinations. Methods of using the mAbs and fragments thereof for cancer therapy and diagnostic imaging are provided, as are methods for making the mAbs and fragments thereof. In vitro cell cultures that express the mAbs and fragments thereof, and kits are also provided.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: July 17, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Kate Rittenhouse-Olson, Julia Abdullah, Jing Ying Eng, Stephen T. Koury
  • Patent number: 9931093
    Abstract: A computerized method for determining an objective tumor response to an anti-cancer therapy using cross-sectional images includes receiving a cross-sectional image of digital medical image data, identifying a set of pixels within the cross-sectional image corresponding to a target lesion, and analyzing the set of pixels with an image processing module to identify an upper and lower threshold of pixel intensities within a total range of pixel intensities, define a subset of pixels from the set of pixels that correspond to vascularized tumor and that have pixel intensities greater than or equal to the lower threshold and lower than or equal to the upper threshold, and derive a vascular tumor burden for the set of pixels. The method further includes determining the objective tumor response for the target lesion, wherein the objective tumor response is based on the vascular tumor burden.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: April 3, 2018
    Assignee: Emass LLC
    Inventor: Andrew Dennis Smith
  • Patent number: 9907866
    Abstract: The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: March 6, 2018
    Assignee: GUERBET
    Inventors: Dominique Meyer, Claire Corot, Marc Port, Vincent Barbotin, Bruno Bonnemain
  • Patent number: 9884987
    Abstract: Nanohybrid preparation methods and compositions, and their usage as oil/water emulsion stabilizers for Chemical Enhanced Oil Recovery (C-EOR). These methods have two main steps: (a) MWCNTs modification; and (b) encapsulation and insertion techniques to insert inorganic nanoparticles into the modified MWCNTs structure. The so-prepared nanohybrids used for the preparation of nanofluids were found to decrease the oil surface tension and reservoir wettability modification from oil-wet to water-wet, which is useful for Chemical Enhanced Oil Recovery (C-EOR).
    Type: Grant
    Filed: February 15, 2015
    Date of Patent: February 6, 2018
    Inventors: Sara Khosravani, Mahshid Ershadi, Mahshad Alaei, Amir Hossein Bornaee, Alimorad Rashidi, Ali Ramazani, Mehrdad Manteghian
  • Patent number: 9823325
    Abstract: The present invention describes methods and compositions for non-invasively assessing the molecular structure of biocompatible hydrogels using MRI analysis. It is shown that biocompatible hydrogels prepared from polymerizing macromolecules that are attached to a paramagnetic, superparamagnetic or ferromagnetic contrast agents form reporter gels wherein monitoring of the changes in the structure of the hydrogels by MRI is facilitated by the presence of such paramagnetic, superparamagnetic or ferromagnetic agents in the biocompatible hydrogel.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: November 21, 2017
    Inventor: Kevin M. Bennett
  • Patent number: 9744138
    Abstract: The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 29, 2017
    Assignees: BioSpecifics Technologies Corp., Duke University, North Carolina Central University
    Inventors: Phyllis Carolyn Leppert, Thomas L. Wegman, Darlene K. Taylor
  • Patent number: 9709511
    Abstract: Apparatus, system, method and computer-readable medium for isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency RF irradiation. A two-pool model for magnetization transfer (MT) can be established fully based on Provotorov's theory of saturation, and then extended to the situation of simultaneous two-frequency RF irradiation. Numerical simulations and experimental results demonstrate that two-frequency RF irradiation can make MT effects independent of irradiation frequency over a wide range, and thus can suppress MT asymmetry. Exemplary embodiments can be provided to isolate chemical exchange saturation transfer (CEST) contrast from MT asymmetry contrast by using the two-frequency RF irradiation technique. A further embodiment can isolate a narrow-frequency spectrum MT mechanism from a broad-frequency spectrum MT mechanism.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: July 18, 2017
    Assignee: New York University
    Inventors: Jae Seung Lee, Ravinder R. Regatte, Alexej Jerschow
  • Patent number: 9702946
    Abstract: Parahydrogen Induced Polarization was employed to prepare nuclear singlet state between methylene and methyl protons in propane gas. Low-field MRI preserves this singlet state with much longer TS=4.7±0.5 s. Spin-Lock Induced Crossing (SLIC) transforms singlet state in observable nuclear magnetization suitable for MRI with sub-millimeter and sub-second spatial and temporal resolution respectively with signal enhancement>10,000 times. Long-lived spin states created in hyperpolarized propane-d6 gas can be detected directly at 0.0475 T. This long lifetime and non-toxic nature of propane gas could be useful for bio-imaging applications including potentially pulmonary low-field MRI. The feasibility of high-resolution low-field 2D gradient-echo MRI was demonstrated with 0.88×0.88 mm2 spatial and ˜0.7 s temporal resolution respectively at 0.0475 T. Propane is a non-toxic gas, and therefore, these results enable low-cost high-resolution high-speed MRI of gases for imaging of lungs.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: July 11, 2017
    Assignee: Konstantin Saprygin
    Inventor: Konstantin Saprygin
  • Patent number: 9693828
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 4, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • Patent number: 9687569
    Abstract: Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: June 27, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Chen Fang
  • Patent number: 9655983
    Abstract: The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: May 23, 2017
    Assignee: GUERBET
    Inventors: Dominique Meyer, Claire Corot, Marc Port, Vincent Barbotin, Bruno Bonnemain
  • Patent number: 9651508
    Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. The thermal contrast reader includes housing having an opening to receive the test strip at a test location, an energy source directed at the test location and a heat sensor directed at the test location. The heat sensor is configured to sense heating of the test strip upon activation of the heat source at the test location, if the target analyte is present in the sample. The heat sensor can provide sensor output using diagnostic circuitry coupled to the sensor output and configured to provide a diagnostic output. The diagnostic output can indicate the diagnostic condition of the patient as a function of the sensor output. The present disclosure also includes methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: May 16, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin