Polypeptide Attached To Or Complexed With The Agent (e.g., Protein, Antibody, Etc.) Patents (Class 424/9.34)
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Patent number: 8697453Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.Type: GrantFiled: October 12, 2012Date of Patent: April 15, 2014Assignee: Life Technologies ASInventors: Ellen Weng, Geir Fonnum, Grete Modahl, Astrid Molteberg, Erling Finne
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Patent number: 8663598Abstract: One embodiment of the disclosure provides an amino sequence of an anti-human transferrin receptor antibody, including: an amino sequence of a heavy chain variable region which is represented by SEQ ID NO.: 1 or SEQ ID NO.: 2, wherein the anti-human transferrin receptor antibody is capable of specifically binding to a human transferrin receptor.Type: GrantFiled: September 11, 2012Date of Patent: March 4, 2014Assignee: Industrial Technology Research InstituteInventors: Ming-Hua Yang, Min-Yuan Chou, Hsiang-Ching Wang
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TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN AND INTO BRAIN CANCER CELLS AND METHODS OF USE THEREOF
Publication number: 20140056820Abstract: The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.Type: ApplicationFiled: September 30, 2013Publication date: February 27, 2014Applicant: The Board of Trustees of the University of IllinoisInventors: Chang Soo Hong, Tohru Yamada, Arsenio M Fialho -
Patent number: 8647604Abstract: An aqueous soluble, lanthanide rich nanoparticle for investigative use, such as NMR, MRI, CT, PET, and GdNCT is provided. The nanoparticle is synthesized from a mixture comprising lanthanide ions and coated with a suitably selected organic ligand such that the resultant nanoparticle is soluble in aqueous solutions. A method of collecting nuclear magnetic resonance information on a sample or a subject is also provided.Type: GrantFiled: January 25, 2007Date of Patent: February 11, 2014Assignee: UVic Industry Partnerships Inc.Inventors: Franciscus C. J. M. VanVeggel, Robert Scott Prosser, Cunhai Dong
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Publication number: 20140037554Abstract: The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.Type: ApplicationFiled: September 9, 2013Publication date: February 6, 2014Applicant: The Boad of Trustees of the University of IllinoisInventors: Ananda Chakrabarty, Tapas Das Gupta, Tohru Yamada, Arsenio Fialho
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Patent number: 8636977Abstract: The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.Type: GrantFiled: March 3, 2006Date of Patent: January 28, 2014Assignee: Bracco Imaging S.p.A.Inventors: Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Carlo Scolastico, Leonardo Manzoni, Daniela Arosio
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Patent number: 8637028Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.Type: GrantFiled: October 9, 2009Date of Patent: January 28, 2014Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's HospitalInventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
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Patent number: 8629240Abstract: Peptides are disclosed that are useful for molecular imaging or diagnosis of a disease state, such as cancer, in which clusterin is upregulated.Type: GrantFiled: April 15, 2010Date of Patent: January 14, 2014Assignee: National Research Council of CanadaInventors: Rana Filfil, Dmitri Tolkatchev, Feng Ni, Maureen D. O'Connor-McCourt, Anne E. G. Lenferink
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Patent number: 8617514Abstract: The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments.Type: GrantFiled: October 20, 2006Date of Patent: December 31, 2013Assignee: Georgetown UniversityInventors: Esther H. Chang, Kathleen F. Pirollo
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Patent number: 8613907Abstract: Disclosed are compositions and methods for reducing the proliferation of cancer cells through targeted interactions with integrins.Type: GrantFiled: March 17, 2003Date of Patent: December 24, 2013Assignee: University of RochesterInventors: Hartmut Land, Laurent Deleu
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Patent number: 8609111Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.Type: GrantFiled: June 7, 2012Date of Patent: December 17, 2013Assignees: University of Massachusetts, Medarex, L.L.C.Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
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Publication number: 20130315840Abstract: A compound including a polymer is represented by general formula (1): L-Y-A??(1) wherein, A is a single-chain antibody moiety, which is a polypeptide including an antigen-binding site, L is a linker moiety, which is a polypeptide including a protease cleavage site, Y is a peptide moiety, which includes 0 or more amino acids connecting the linker moiety L with the single-chain antibody moiety A, and the linker moiety L binds to an N terminus of the peptide moiety Y or an N terminus of the single-chain antibody moiety A.Type: ApplicationFiled: April 30, 2013Publication date: November 28, 2013Applicant: CANON KABUSHIKI KAISHAInventors: Satoshi Ogawa, Fumio Yamauchi, Kengo Kanazaki, Mayuko Kishi
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Publication number: 20130309177Abstract: The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes. Preferably, the diagnostic complex is of use for 18F imaging, while the therapeutic complex is of use for targeted delivery of chemotherapeutic drugs or toxins. More preferably, a chelating moiety or targetable construct may be conjugated to a targeting molecule, such as an antibody or antibody fragment, using a click chemistry reaction involving cyclooctyne, nitrone or azide reactive moieties. In most preferred embodiments, the click chemistry reaction occurs in vivo. In vivo click chemistry is not limited to 18F labeling but can be used for delivering a variety of therapeutic and/or diagnostic agents.Type: ApplicationFiled: June 14, 2013Publication date: November 21, 2013Applicant: IMMUNOMEDICS, INC.Inventors: William J. McBride, Christopher A. D'Souza, David M. Goldenberg
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Patent number: 8574549Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: GrantFiled: December 29, 2008Date of Patent: November 5, 2013Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michacl Ernest Marino
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Patent number: 8574583Abstract: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.Type: GrantFiled: November 15, 2011Date of Patent: November 5, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mark Kay, Dirk Grimm
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Publication number: 20130280173Abstract: The invention provides a fusion ferritin protein wherein a ferritin heavy chain polypeptide is fused to a peptide, wherein the peptide is fused to the C-terminal end of the ferritin heavy chain; and the peptide includes at least a portion of a Mms6 protein sequence and at least one heterologous amino acid at its N-terminal end. The invention further provides methods of use of the ferritin fusion protein for Magnetic Resonance Imaging.Type: ApplicationFiled: April 4, 2013Publication date: October 24, 2013Inventors: Michal NEEMAN, Raz Zarivach, Marina Radoul, Batya Cohen, Moriel Vandsburger, Limor Lewin
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Patent number: 8562953Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is CH2CH2Ol, and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.Type: GrantFiled: October 2, 2012Date of Patent: October 22, 2013Assignee: Industrial Technology Research InstituteInventors: Dhakshanamurthy Thirumalai, Chin-I Lin, Shian-Jy Wang
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Patent number: 8540965Abstract: The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.Type: GrantFiled: July 31, 2006Date of Patent: September 24, 2013Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: David A. Scheinberg, Michael McDevitt, Christophe Antczak, Debjit Chattopadhyay, Rena May, Jón Njardarson, Mark Reid Philips
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Publication number: 20130243700Abstract: The present invention provides compositions and methods for shielding and directing agents to biological targets in cellular systems for therapeutic, prophylactic, and diagnostic uses. Vascular devices are also provided which have coated surfaces that contain proteomic antisense, as well as therapeutic and other biological agents attached thereto.Type: ApplicationFiled: February 28, 2011Publication date: September 19, 2013Inventors: Lance Liotta, David Geho, Emanuel Petricoin
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Patent number: 8536314Abstract: The present invention provides variants of fluorescent proteins, which are improved with regard to their properties for use as reporter proteins and/or in analytics. In particular, variants of fluorescent proteins are provided, which fluoresce brighter, show improved quantum yield and/or have shifted excitation or emission spectra. The fluorescent proteins according to the invention comprise in their LOV domain besides the substitution of a cysteine with an amino acid that does not covalently bind FMN at least one further point mutation.Type: GrantFiled: May 19, 2010Date of Patent: September 17, 2013Assignee: Evocatal GmbHInventors: Thorsten Eggert, Sascha Hausmann, Michael Puls
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Patent number: 8529900Abstract: The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer.Type: GrantFiled: April 14, 2009Date of Patent: September 10, 2013Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Assistance Publique Hopitaux de ParisInventors: Marco Alifano, Patricia Forgez
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Patent number: 8529901Abstract: This invention relates to a composition of a non-labeled monoclonal antibody binding to a tumor antigen and a second monoclonal antibody labeled with a NIR fluorescence label, binding to the same tumor antigen, wherein the first and second antibody exhibit no cross reactivity. The composition can be used for the treatment of patients suffering of solid tumors which are associated with an overexpression of such a tumor antigen. The invention further relates to a the co-administration of said first and second antibody as wells as to a method of acquiring a NIR fluorescence images of such tumors or the patients suffering from such tumors during the treatment of said patient with such composition.Type: GrantFiled: June 4, 2008Date of Patent: September 10, 2013Assignee: Hoffmann-La Roche, Inc.Inventors: Max Hasmann, Helmut Lenz, Werner Scheuer
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Patent number: 8524240Abstract: The present invention relates to the field of diagnosis and therapy of hematological malignancies based on the tumor antigen FMR1NB (also called NY-SAR-35, Cancer/testis antigen 37 or Fragile X mental retardation 1 neighbor protein) and agents specifically targeting this antigen or cells expressing the same, e.g., antibodies. The inventors were able to prove that the molecule is expressed on the cell surface and thus represents a particularly advantageous target in cancer therapy and vaccination. Surprisingly, FMR1NB was found to be associated with hematological malignancies, e.g. acute myeloid leukemia (AML) or chronic myeloid leukemia (CML).Type: GrantFiled: October 25, 2010Date of Patent: September 3, 2013Inventors: Djordje Atanackovic, Tim Luetkens
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Publication number: 20130216479Abstract: Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous adducts such as, the corresponding oxime derivatives is provided. Methods of making and using the adducts in radio-labelling, molecular imaging applications, and treatment of disorders such as cancer, Crohn's disease, arthritis, atherothrombosis and plaque rupture are also provided.Type: ApplicationFiled: April 1, 2013Publication date: August 22, 2013Inventors: Alexander Krantz, Peng Yu
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Patent number: 8507286Abstract: Disclosed is a method of analyzing an oxidation state of a methionine residue in a protein sample, which comprises the steps of: inducing a reaction between a protein sample having a methionine residue with an oxidation state to be analyzed, and hydrogen peroxide H218O2 having oxygen atoms labeled by the isotope 18O, to obtain a modified protein sample in which the oxidation state of the methionine residue is stabilized; and subjecting the modified protein sample to a measurement to quantify an oxidation degree of the methionine residue. Preferably, the measurement is a mass spectrometric (MS) measurement using a mass spectrometer. The method can analyze an oxidation state of a methionine residue in a protein sample, in a simple manner, while accurately reflecting an in vivo oxidation state of the methionine residue.Type: GrantFiled: November 20, 2008Date of Patent: August 13, 2013Assignee: Shimadzu CorporationInventor: Hirotaka Fujimoto
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Publication number: 20130189189Abstract: Provided is a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8(IL-8) or GRO-? and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-?, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.Type: ApplicationFiled: November 19, 2012Publication date: July 25, 2013Applicant: Medipost Co., Ltd.Inventor: Medipost Co., Ltd.
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Patent number: 8487079Abstract: Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group covalently linked to a mitochondria-targeting group derived from a hemigramicidin moiety. The mitochondria-targeted electron scavenger can be used to treat medical conditions associated with acute or chronic inflammation.Type: GrantFiled: August 8, 2008Date of Patent: July 16, 2013Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Mitchell P. Fink, Peter Wipf
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Patent number: 8486409Abstract: The present invention discloses alpha particle emitting, radioactive constructs capable of killing large tumors (>1 mm in diameter), or other cells involved in human or animal diseases such as virus infected cells, autoimmune cells, or other pathological cells, including normal cells, that are targets for destruction, to achieve a therapeutic result. The alpha-emitting constructs have high specific activity.Type: GrantFiled: April 20, 2010Date of Patent: July 16, 2013Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: David A. Scheinberg, Michael R. McDevitt, Dangshe Ma, George Sgouros
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Publication number: 20130171061Abstract: One embodiment of the disclosure provides an amino sequence of an anti-human transferrin receptor antibody, including: an amino sequence of a heavy chain variable region which is represented by SEQ ID NO.: 1 or SEQ ID NO.: 2, wherein the anti-human transferrin receptor antibody is capable of specifically binding to a human transferrin receptor.Type: ApplicationFiled: September 11, 2012Publication date: July 4, 2013Inventors: Ming-Hua YANG, Min-Yuan Chou, Hsiang-Ching Wang
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Patent number: 8470785Abstract: Compositions and methods for treating ocular cancer are provided. The composition is a subconjunctival formulation of nutlin-3 and its analogs. The composition provides for methods of treating ocular cancer, including retinoblastoma. The formulation has high penetration into ocular tissue with low toxicity.Type: GrantFiled: September 27, 2011Date of Patent: June 25, 2013Assignees: St. Jude Children's Research Hospital, Leiden University Medical Center, VIB VZW and Universiteit GentInventors: Michael A. Dyer, Jean-Christophe Marine, Aart Gerrit Jochemsen, R. Kip Guy, Fangyi Zhu
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Publication number: 20130121927Abstract: The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted magnetic nanoparticles and special magnetic systems. The magnetic systems can comprise magnetizing subsystems and sensors subsystems, including as examples SQUID sensors and atomic magnetometers. The magnetic systems can detect, measure, or location particles bound by antibodies to cells or substances of predetermined types. Example magnetic systems are capable of detecting sub-nanogram amounts of these nanoparticles.Type: ApplicationFiled: November 5, 2010Publication date: May 16, 2013Inventor: Edward R. Flynn
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Publication number: 20130121928Abstract: An improved method for diagnosing and characterizing peripheral nerve lesions to permit early identification and characterization of peripheral nerve injuries that will require surgical intervention.Type: ApplicationFiled: November 13, 2012Publication date: May 16, 2013Inventor: Sam Popinchalk
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Patent number: 8440169Abstract: The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13C, 2 to 4 carbon atoms of the remaining 5 carbon atoms constituting the phenyl group are 12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are 13C atoms to which hydrogen atoms are linked, and a stable isotope-labeled tyrosine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13C, the carbon atom bonded to the hydroxyl group (OH group) of the phenyl group is 12C or 13C, 2 to 4 carbon atoms of the remaining 4 carbon atoms constituting the phenyl group are 12C atoms to which deuterium atoms are bonded, and the remaining carbon atoms are 13C atoms to which hydrogen atoms are linked.Type: GrantFiled: September 14, 2009Date of Patent: May 14, 2013Assignee: Japan Science and Technology AgencyInventors: Masatsune Kainosho, Tsutomu Terauchi
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Publication number: 20130101504Abstract: The invention provides SPARC binding antibodies that target disease sites, in particular, tumors and uses thereof to diagnose and treat diseases, in particular, cancerous tumors.Type: ApplicationFiled: April 26, 2011Publication date: April 25, 2013Applicant: ABRAXIS BIOSCIENCE, LLCInventors: Vuong Trieu, Xiping Liu, Neil Desai
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Patent number: 8425878Abstract: The present invention is directed to the identification of a biomarker specifically located in the plasma membrane of pancreatic beta cells. It was selected by a Systems Biology approach on Massively Parallel Signal Sequencing datasets obtained in human islets and Affymetrix microarray datasets on human islets, purified rat primary beta and non beta cells and insulinoma cells. Based on a set of specific features the biomarker is a unique candidate for imaging and targeting strategies to study the pancreatic beta cell mass in health and disease (T1 D, T2D, pancreatic cancers, obesity, islet transplantation, beta cell regeneration).Type: GrantFiled: February 13, 2009Date of Patent: April 23, 2013Assignee: Universite Libre de BruxellesInventors: Decio L. Eizirik, Daisy Flamez, Isabelle Salmon, Alix Berton, Isabelle Roland, Daniel Marechal, Marie-Claire Beckers, Leroy Hood, Nathan Goodman, Burak Kutlu
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Publication number: 20130095036Abstract: The present invention features noninvasive methods for diagnosing IgA or IgM kidney disorders, such as IgA nephropathy, Henoch-Schönlein purpura, and IgM nephropathy, in a mammal. The invention also features compositions and kits useful in diagnosing these disorders.Type: ApplicationFiled: April 4, 2012Publication date: April 18, 2013Applicants: New England Medical Center Hospitals, Inc., RQ Bioscience, Inc.Inventors: Robert Qiu, Jiazhou Qiu, Andrew G. Plaut
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Publication number: 20130095037Abstract: In the current invention peptides, which are derived from GLP-1 (glucagon-like peptide-1) and exendin-3 and/or exendin-4, are provided which bond to the GLP-1 receptor and can be used, labeled or unlabeled, for the production of an agent for diagnostic and therapy of benign and malignant diseases, in which GLP-1 receptor expression plays a role.Type: ApplicationFiled: August 24, 2012Publication date: April 18, 2013Applicant: Philipps-Universitat MarburgInventors: Martin GOTTHARDT, Martin Béhé, Thomas Behr, Burkhard J. Göke
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Patent number: 8420055Abstract: Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.Type: GrantFiled: May 9, 2008Date of Patent: April 16, 2013Assignee: VisEn Medical, Inc.Inventors: Debra A. Gaw, Lee Josephson
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Publication number: 20130084247Abstract: The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.Type: ApplicationFiled: July 30, 2012Publication date: April 4, 2013Applicant: The Board of Trustees of the University of IllinoisInventors: Tapas Das Gupta, Ananda Chakrabarty, Craig Beattie, Tohru Yamada
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Publication number: 20130078189Abstract: The present invention provides a method of forming an oxidatively-stable aqueous Eu(II) complex by synthesizing ligands that coordinate to large, soft, electron rich metals like Eu(II). The invention also provides an oxidatively stable aqueous Eu(II) complex. The complex can be used for a variety of purposes some of which include, but are not limited to, in paramagnetic chemical exchange saturation transfer, as a medical diagnostic, as a semiconductor, and for use in forming materials.Type: ApplicationFiled: January 19, 2011Publication date: March 28, 2013Inventors: Matthew J. Allen, Nipuni Dhanesha H. Gamage, Joel Garcia, Jeremiah Moore
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Publication number: 20130064765Abstract: The present invention encompasses an antithrombotic nanoparticle.Type: ApplicationFiled: December 17, 2010Publication date: March 14, 2013Applicant: THE WASHINGTON UNIVERSITYInventors: Jacob Myerson, Samuel A. Wickline
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Publication number: 20130064762Abstract: This invention generally relates to a method of identifying pre-neoplastic or neoplastic tissue of a mammal by utilizing autoantibodies that detect the pre-neoplastic or neoplastic tissue. Also described herein are methods of killing pre-neoplastic or neoplastic tissue by either binding toxins to autoantibodies that detect the pre-neoplastic or neoplastic tissue or introducing toxin-conjugated molecules that can in turn recognize the autoantibodies already bound to the pre-neoplastic or neoplastic tissue.Type: ApplicationFiled: September 12, 2012Publication date: March 14, 2013Applicant: The Rockefeller UniversityInventor: Sanford M. Simon
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Publication number: 20130058873Abstract: The present invention is related to fragments of human melanotransferrin (p97). In particular, this invention relates to treatment of diseases through the introduction of the melanotransferrin fragment conjugated to a therapeutic or diagnostic agent to a subject.Type: ApplicationFiled: August 3, 2012Publication date: March 7, 2013Applicant: BIOASIS TECHNOLOGIES, INC.Inventors: Wilfred Jefferies, Mei Mei Tian, Timothy Vitalis
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CHEMICAL EXCHANGE SATURATION TRANSFER BASED MRI USING REPORTER GENES AND MRI METHODS RELATED THERETO
Publication number: 20130058874Abstract: Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes chemical exchange saturation transfer (CEST) technique for imaging.Type: ApplicationFiled: August 3, 2012Publication date: March 7, 2013Applicant: The Johns Hopkins UniversityInventors: Peter C.M. van Zijl, Assaf A. Gilad, Jeff Bulte, Michael T. McMahon, Raman Venu, Paul T. Winnard, JR. -
Publication number: 20130058865Abstract: The invention encompasses radiopharmaceutical compounds that can be used in imaging cell death associated with either apoptosis or necrosis. Phosphatidylethanolamine (PtdE) is externalized to the surface of apoptotic cells, and also becomes accessible in necrotic cells due to compromised plasma membrane integrity. Duramycin, a 19 amino acid polypeptide, binds PtdE at a 1:1 ratio with high affinity and exclusive specificity. Novel Duramycin-based radiopharmaceuticals and non-radioactively labeled compounds are disclosed herein. Such compounds facilitate detection of cell apoptosis and/or necrosis by binding to PtdE. The location of the bound compound can then be pinpointed using standard imaging techniques.Type: ApplicationFiled: January 10, 2011Publication date: March 7, 2013Inventor: Ming ZHAO
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Patent number: 8388937Abstract: A specific targeting peptide binding to glypican-3 can specifically binds to glypican-3 overexpressed in carcinoma cells and includes an amino acid sequence represented by SEQ ID NO:1 or some thereof. Glypican-3 is overexpressed in malignant tumors including hepatocellular carcinoma, melanoma, germ cell tumor, etc., and may be targeted in diagnosis and treatment of tumors by labeling the targeting peptide. A diagnosis using the specific peptide may detect even small tumors more accurately than conventional methods. A treatment method using the specific peptide may remove only carcinoma cells without harming other normal tissues.Type: GrantFiled: February 12, 2010Date of Patent: March 5, 2013Assignee: Kyungpook National University Industry—Academic Cooperation FoundationInventors: Byeong Cheol Ahn, Jae Tae Lee, Je Yeol Cho, Jung Soo Yu, Yong Jin Lee, Sang Woo Lee, You La Lee
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Patent number: 8388976Abstract: A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the fusion protein are disclosed.Type: GrantFiled: August 17, 2012Date of Patent: March 5, 2013Assignee: Samsung Electronics Co., Ltd.Inventors: A-yeon Cho, Min-kyung Kim, Brian Hosung Min, Jong-sang Ryu
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Publication number: 20130045161Abstract: A new approach to targeting imaging agents to macrophage-rich sites of interest is disclosed. Compositions of the invention are rHDL and HDL-like liposomal compositions, protein constituents of which, apolipoproteins A-I and/or A-II or fragments thereof are used not only as structural but also as targeting agents. This is achieved by certain controlled chemical or enzymatic modification of apolipoproteins A-I or A-II or fragments thereof. Such modification converts these apolipoproteins to substrates for macrophage scavenger receptors and results in the improvement of contrast agent-(HDL/modified apolipoprotein)-particle association with macrophages and/or absorption (uptake) by macrophages when compared to that of the contrast agent-(HDL/apolipoprotein)-particle constructed with non-modified naturally occurring apo A-I.Type: ApplicationFiled: October 10, 2010Publication date: February 21, 2013Applicant: SIGNABLOK, INC.Inventor: Alexander B. Sigalov
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Patent number: 8380282Abstract: The invention concerns a system capable of generating a magnetic indication B0 comprising gradients (Gx, Gy, Gz) in certain directions, transmitting ratio frequency wave pulse sequences (RF) perpendicular to B0 in a range of adjustable frequencies, and detecting electromagnetic signals received from a body part (4). The method includes injecting a contrast product in said body part, capable of being temporarily fixed in an observed zone (1), and comprising an element capable of causing chemical displacement of a resonance frequency of water hydrogen protons; exciting said body part, using a radio wave pulse sequence; in a range of frequencies adjusted on the basis of the magnetic induction B0 and the chemical displacement for some of said waves; detecting the electromagnetic signals received in said body part, substantially corresponding to the magnetic resonance signals of the protons of the observed zone having undergone the chemical displacement.Type: GrantFiled: July 6, 2010Date of Patent: February 19, 2013Assignees: Centre National de la Recherche and Scientifique—CNRS, Universite Victor Segalen Bordeaux 2Inventors: Jean-Michel Franconi, Sylvain Miraux, Eric Thiaudiere, Paul Canioni
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Patent number: 8367040Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.Type: GrantFiled: April 20, 2012Date of Patent: February 5, 2013Assignee: Georgia State University Research Foundation, Inc.Inventors: Jenny Jie Yang, Zhi-Ren Liu