Abstract: A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone structure, each spacer arm terminating in at least one paramagnetic complex. The polymeric backbone thus serves as an amplifier by supporting a multitude of paramagnetic complexes, and the spacer arms contribute to the molecular weight. The spacer arms further contribute useful properties to the agent, such as hydrophilicity and the ability to cleave at a relatively rapid rate in blood.
Type:
Grant
Filed:
June 12, 1998
Date of Patent:
November 6, 2001
Assignee:
The Regents of the University of California
Inventors:
Robert C. Brasch, Jeffry S. Mann, Danute E. Nitecki
Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
Type:
Application
Filed:
March 30, 1998
Publication date:
October 25, 2001
Inventors:
CHUN LI, SIDNEY WALLACE, DONG-FANG YU, DAVID J. YANG
Abstract: The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
Type:
Grant
Filed:
January 21, 2000
Date of Patent:
October 16, 2001
Assignee:
Department of Health The Executive Yuan, Republic of
China
Abstract: In a method for characterizing the angiogenesis status of a tumor in a living subject, timed magnetic resonance images of the subject into whom a reptating polymer contrast agent containing chelating diethylentriaminepentacetic acid dosed with gadolinum has been introduced are obtained. At least two images taken at different times are compared in order to determine the percentage image enhancement in a tumor region of interest.
Abstract: The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.
Type:
Grant
Filed:
January 10, 2000
Date of Patent:
July 3, 2001
Assignee:
Schering Aktiengesellschaft
Inventors:
Werner Krause, Franz-Karl Maier, Michael Bauer, Gabriele Schuhmann-Giampieri, Wolf-Rudiger Press, Peter Muschik
Abstract: Cascade polymer complexes containing
a) complexing ligands of general formula I
A—{X—[Y—(Z—( W—Kw)z)y]x}a (I)
in which
A stands for a nitrogen-containing cascade nucleus of base multiplicity a,
X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,
Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,
K stands for the radical of a complexing agent,
a stands for numbers 2 to 12,
x, y, z and w, independently of one another, stand for numbers 1 to 4,
provided that at least two reproduction units are different and that
16≦a·x·y·z·w≦64
holds true for the product of the multiplicities,
b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83 and
c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuab
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
June 19, 2001
Assignee:
Schering Aktiengesellschaft
Inventors:
Heribert Schmitt-Willich, Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Andreas Muhler, Thomas Frenzel, Wolfgang Ebert
Abstract: A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
Type:
Grant
Filed:
October 12, 1994
Date of Patent:
May 15, 2001
Inventors:
Jon Faiz Kayyem, Thomas J. Meade, Scott E. Fraser
Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
Type:
Grant
Filed:
February 22, 2000
Date of Patent:
February 27, 2001
Assignee:
Schering AG
Inventors:
Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
Type:
Grant
Filed:
September 17, 1998
Date of Patent:
February 6, 2001
Assignee:
Schering Aktiengesellschaft
Inventors:
Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schumann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
Type:
Grant
Filed:
March 19, 1998
Date of Patent:
January 23, 2001
Assignee:
Schering Aktiengeseuschaft
Inventors:
Heribert Schmitt-Willich, Johannes Platzek, Bernd Rad{umlaut over (u)}chel, Andreas M{umlaut over (u)}hler, Thomas Frenzel