Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
Type:
Grant
Filed:
August 10, 2001
Date of Patent:
November 16, 2004
Assignee:
Schering Aktiengesellschaft
Inventors:
Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
Abstract: Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
Type:
Grant
Filed:
August 27, 2002
Date of Patent:
October 12, 2004
Assignee:
Bracco Imaging S.p.A.
Inventors:
Christoph De Haen, Andrea Beltrami, Enrico Cappelletti, Luciano Lattuada, Mario Virtuani
Abstract: New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive properties. Conjugation with peptides or protein can be achieved by the presence of a linker moiety in the molecular structure of these chelators.
Abstract: Perfluoroalkyl-containing complexes with polar radicals of general formula I
(K)1-G-(Z-Rf)m(R)p (I)
in which R means the polar radical, Rf means a perfluorinated carbon chain, K is a metal complex, and Z represents a linker group,
are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
Type:
Grant
Filed:
August 10, 2001
Date of Patent:
January 13, 2004
Assignee:
Schering Aktiengesellschaft
Inventors:
Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
Abstract: Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
Type:
Application
Filed:
June 16, 2003
Publication date:
November 6, 2003
Applicant:
Schering AG
Inventors:
Heinz Gries, Ulrich Speck, Hanns-Joachim Weinmann, Hans Peter Niendorf, Wolfgang Seifert
Abstract: Perfluoroalkyl-containing complexes with sugar radicals of general formula I
in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position, Rf means a perfluorinated carbon chain, K is a metal complex, and Y and Z represent linker groups,
are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
Type:
Grant
Filed:
August 10, 2001
Date of Patent:
November 4, 2003
Assignee:
Schering Aktiengesellschaft
Inventors:
Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
Abstract: This invention relates to the use of particular contrast agents to prepare diagostic compounds suitable for non-invasive visualisation under physiological conditions of the intestinal tract, and the colon in particular.
Type:
Application
Filed:
May 1, 2000
Publication date:
June 19, 2003
Inventors:
Michael V. Knopp, Frederik Giesel, Hendrik Von Tengg-Kobligk, Jannis Radeleff
Abstract: The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed.
Abstract: Compounds of formula I
wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.
Type:
Grant
Filed:
March 10, 2000
Date of Patent:
May 20, 2003
Assignee:
Schering Aktiengesellschaft
Inventors:
Heinz Gries, Erich Klieger, Bernd Radüchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jürgen Conrad
Abstract: The present invention relates to methods for contrast-enhanced imaging of sexual response. In particular, the present invention relates to methods of magnetic resonance imaging (MRI), computerized X-ray tomography (CT), ultrasound, and optical imaging using contrast agents to measure blood flow during sexual response, especially female sexual response. The invention relates to methods of analyzing normal sexual function and sexual dysfunction and provides a means for evaluating and screening potential therapeutic compounds for enhancing sexual function or treating sexual dysfunction.
Type:
Grant
Filed:
November 21, 2000
Date of Patent:
April 15, 2003
Assignee:
EPIX Medical, Inc.
Inventors:
Robert M. Weisskoff, Stephen C. Knight, Wayne Carter
Abstract: The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.
Type:
Grant
Filed:
August 1, 2000
Date of Patent:
February 18, 2003
Assignee:
California Institute of Technology
Inventors:
Thomas J. Meade, Scott E. Fraser, Russell E. Jacobs
Abstract: The invention relates to injectable compositions for increasing the image contrast between specific organ areas in the magnetic resonance imaging (MRI) of human and animal patients. This enables better differentiation of neighboring tissue portions. Methods of the preparation of such compositions and their use in the MRI of living subjects are also disclosed.
Abstract: A new process for the preparation of diethylenetriaminepentaacetic-monoamides in which amines can be reacted with sensitive groups, a higher mono/diamide selectivity is achieved, a higher yield of monoamide is achieved and has a simple reaction scheme and working-up.
Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.
The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
Type:
Grant
Filed:
November 8, 1999
Date of Patent:
October 22, 2002
Assignee:
Schering Aktiengesellschaft
Inventors:
Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
Abstract: Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.
Type:
Grant
Filed:
May 26, 1999
Date of Patent:
October 8, 2002
Assignee:
Bracco Imaging S.p.A.
Inventors:
Pier Lucio Anelli, Marino Brocchetta, Christoph De Haen, Ornella Gazzotti, Luciano Lattuada, Giovanna Lux, Giuseppe Manfredi, Pierfrancesco Morosini, Daniela Palano, Michele Serleti, Fulvio Uggeri, Massimo Visigalli
Abstract: Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.
Abstract: Chelate compounds of general formula I
wherein
X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and
Z1, Z2, R1, R2, R3 and R4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.
Type:
Grant
Filed:
April 28, 1998
Date of Patent:
September 11, 2001
Assignee:
Schering Aktiengesellschaft
Inventors:
Heinz Gries, Erich Klieger, Bernd Radüchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jürgen Conrad
Abstract: The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.
Type:
Grant
Filed:
January 10, 2000
Date of Patent:
July 3, 2001
Assignee:
Schering Aktiengesellschaft
Inventors:
Werner Krause, Franz-Karl Maier, Michael Bauer, Gabriele Schuhmann-Giampieri, Wolf-Rudiger Press, Peter Muschik
Abstract: Cascade polymer complexes containing
a) complexing ligands of general formula I
A—{X—[Y—(Z—( W—Kw)z)y]x}a (I)
in which
A stands for a nitrogen-containing cascade nucleus of base multiplicity a,
X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,
Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,
K stands for the radical of a complexing agent,
a stands for numbers 2 to 12,
x, y, z and w, independently of one another, stand for numbers 1 to 4,
provided that at least two reproduction units are different and that
16≦a·x·y·z·w≦64
holds true for the product of the multiplicities,
b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83 and
c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuab
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
June 19, 2001
Assignee:
Schering Aktiengesellschaft
Inventors:
Heribert Schmitt-Willich, Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Andreas Muhler, Thomas Frenzel, Wolfgang Ebert
Abstract: A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
Type:
Grant
Filed:
October 12, 1994
Date of Patent:
May 15, 2001
Inventors:
Jon Faiz Kayyem, Thomas J. Meade, Scott E. Fraser
Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
Type:
Grant
Filed:
February 22, 2000
Date of Patent:
February 27, 2001
Assignee:
Schering AG
Inventors:
Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
Type:
Grant
Filed:
March 19, 1998
Date of Patent:
January 23, 2001
Assignee:
Schering Aktiengeseuschaft
Inventors:
Heribert Schmitt-Willich, Johannes Platzek, Bernd Rad{umlaut over (u)}chel, Andreas M{umlaut over (u)}hler, Thomas Frenzel