X-ray Contrast Imaging Agent (e.g., Computed Tomography, Angiography, Etc.) Patents (Class 424/9.4)
  • Patent number: 11547721
    Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: January 10, 2023
    Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, UNIVERSITA DEGLI STUDI DI GENOVA, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Markus Barthel, Marco Cassani, Mariangela Figini, Juan Granja, Teresa Pellegrino, Alessandra Quarta
  • Patent number: 11534410
    Abstract: Compositions of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000 are described. Methods of administering nanolipid carrier molecules are also described. Also described is a method for treating fungal ocular infections by topical ocular administration of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: December 27, 2022
    Assignee: UNIVERSITY OF MISSISSIPPI
    Inventors: Soumyajit Majumdar, Akash Patil, Prit Lakhani
  • Patent number: 11529438
    Abstract: Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: December 20, 2022
    Assignee: BIOVENTUS, LLC
    Inventors: Christopher Wilson, Eric Vanderploeg, Cheryl Lee, Chase Davis, Howard Seeherman, John Wozney
  • Patent number: 11460772
    Abstract: A positive resist composition comprising a base polymer comprising recurring units containing an optionally substituted amino group and iodine exhibits a high sensitivity, high resolution, low edge roughness (LER, LWR) and small size variation, and forms a pattern of good profile after exposure and development.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: October 4, 2022
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Masaki Ohashi
  • Patent number: 11419952
    Abstract: Described is a versatile surface modification approach to, for example, modularly and orthogonally functionalize nanoparticles (NPs) such as, for example, PEGylated nanoparticles, ith various types of different functional ligands (functional groups) on the NP surface. It enables the synthesis of, for example, penta-functional PEGylated nanoparticles integrating a variety of properties into a single NP, e.g., fluorescence detection, specific cell targeting, radioisotope chelating/labeling, ratiometric pH sensing, and drug delivery, while the overall NP size remains, for example, below 10 nm.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: August 23, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: Kai Ma, Ulrich B. Wiesner
  • Patent number: 11410341
    Abstract: An image processing system is provided. The image processing system includes a display, a processor, and a memory. The memory stores processor-executable code that when executed by the processor causes receiving an image of a region of interest of a patient with a medical tube or line disposed within the region of interest, detecting the medical tube or line within the image, generating a combined image by superimposing a first graphical marker on the image that indicates an end of the medical tube or line, and displaying the combined image on the display.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: August 9, 2022
    Assignee: GE PRECISION HEALTHCARE LLC
    Inventors: Alec Joseph Baenen, Pal Tegzes, Levente Torok, Teri Lynn Fischer, Katelyn Rose Nye, Gireesha Chinthamani Rao
  • Patent number: 11338054
    Abstract: A method for promoting spine fusion inside intersomatic cages, comprising placing a fusion cage between two vertebral bodies, and injecting a bone cement paste inside said fusion cage, said bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: May 24, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, ONIRIS, GRAFTYS
    Inventors: Jean-Michel Bouler, Olivier Gauthier, Bruno Bujoli, Pascal Janvier, Charlotte Mellier
  • Patent number: 11285674
    Abstract: A 3D virtual hand is generated and is geo-registered to a tangible object. When the tangible object changes in position, so too does the 3D virtual hand. When the tangible object changes in orientation, so too does the 3D virtual hand. The 3D virtual hand is displayed on an extended reality head display unit. Applications include, but are not limited to, teaching music lessons.
    Type: Grant
    Filed: December 6, 2020
    Date of Patent: March 29, 2022
    Inventor: Robert Edwin Douglas
  • Patent number: 11253627
    Abstract: An embolic material contains at least one type of polymer and a liposoluble contrast medium. A method for producing an embolic material includes extruding a raw material that is in a molten state into a solvent, and cooling the raw material so as to solidify the raw material. The raw material contains a polymer and a liposoluble contrast medium.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 22, 2022
    Assignee: DREAM MEDICAL PARTNERS CORPORATION
    Inventors: Kenta Bito, Terumitsu Hasebe, Atsushi Hotta
  • Patent number: 11090873
    Abstract: In this patent, a method and apparatus for improving analysis of a 3D printed object is provided. A first portion of a 3D dataset is selected for 3D printing. The 3D dataset is geo-registered to the 3D printed object. A second portion of the 3D dataset is displayed on a head display unit (HDU). Additional advanced features are discussed herein. An example would be performing 3D printing of a heart from a CT scan and displaying the aorta and inferior vena cave on the HDU geo-registered to the 3D printed heart.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: August 17, 2021
    Inventor: Robert Edwin Douglas
  • Patent number: 10912811
    Abstract: The present invention relates to a composition for improving peripheral circulation and lymph drainage. The composition includes at least one extract of a fatty plant, at least one extract of a plant having astringent properties, and at least one extract of a plant with one or more effects including anti-inflammatory, formation of new, healthy collagen fibrilles, antiseptic properties, antioxidant, neutralizing free radicals, antiedematous, vitaminazing, and stimulating wound healing. The composition may be used to treat at least one of varicose veins, swollen legs, painful legs, stasis dermatitis, swollen arms, indurated arms, hematomas, ecchymosis, periorbital dark circles, periorbital swelling, and hemorrhoids.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: February 9, 2021
    Inventors: Felician Stancioiu, Daniela Catanas
  • Patent number: 10898606
    Abstract: An adhesive free self-fusing material being either of open or closed cell polymer (silicone) based material that can be used to create a permanent elastic band for compression and support dressings. The proprietary polymer material upon contact with itself, initiates a “room temperature” reaction of self-vulcanization with the contact surfaces of itself. This eliminates the need for any adhesives which some patients experience negative reactions. In an example embodiment, the material comprises Vinyl stopped polydimethyl siloxane, amorphous silica, and dimethylpolysiloxane.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: January 26, 2021
    Inventors: Michael E. Stein, Sean Dickson
  • Patent number: 10898165
    Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: January 26, 2021
    Assignee: Avent, Inc.
    Inventors: Alfred C. Coats, Louis Lupin
  • Patent number: 10846911
    Abstract: In this patent, we teach a method and apparatus for displaying flow-type visualization features that move in accordance with fluid dynamics models on extended reality displays. A user is able to select the type of flow of interest and the type of flow of non-interest and then display the type of flow of interest unhindered by the type of flow of non-interest. This technique has applications in medicine, such as modeling flow inside of the carotid artery. Also, outside of the medical field, this technique can have applications, such as in aeronautical engineering.
    Type: Grant
    Filed: February 2, 2020
    Date of Patent: November 24, 2020
    Inventor: Robert Edwin Douglas
  • Patent number: 10495968
    Abstract: A monomer having formula (I): wherein in formula (I), groups and variables are the same as described in the specification.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: December 3, 2019
    Assignee: ROHM AND HAAS ELECTRONIC MATERIALS LLC
    Inventors: Emad Aqad, James W. Thackeray, James F. Cameron
  • Patent number: 10487037
    Abstract: A process for preparing an iodinated fatty acid ethyl ester includes steps of subjecting a fatty acid ester to a protonation reaction with phosphoric acid to form a protonated fatty acid ester, and subjecting the protonated fatty acid ester to an iodination reaction with an alkali metal iodide to obtain an iodinated fatty acid ester.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: November 26, 2019
    Assignee: Food Industry Research and Development Institute
    Inventors: Chih-Chiang Lin, Chih-Hong Tung, Yan-Hwa Chu, Ding-Yuan Su
  • Patent number: 10485780
    Abstract: The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: November 26, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Shuo Wei, Xiao Zhen Zhou
  • Patent number: 10478512
    Abstract: The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: November 19, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Georgia State University Research Foundation Inc.
    Inventors: John V. Frangioni, Maged M. Henary
  • Patent number: 10311273
    Abstract: A thermal tag includes a power source to generate current along a resistive path and a plurality of infrared-emitting features positioned along the resistive path to emit infrared light along an infrared-emitting pattern, wherein the plurality of infrared-emitting features include one or more infrared-emitting stripes on a first surface of the thermal tag defining a pattern region and a plurality of infrared-emitting dots within a portion of the pattern region to provide a thermal-diffusion resistant pattern for activity monitoring.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: June 4, 2019
    Assignee: International Business Machines Corporation
    Inventors: Li-Wen Hung, Jui-Hsin Lai
  • Patent number: 10276735
    Abstract: A semiconductor nanocrystal include a first I-III-VI semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. Populations of the nanocrystals can have an emission FWHM of no greater than 0.35 eV.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: April 30, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Peter Matthew Allen, Moungi G. Bawendi
  • Patent number: 10231702
    Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 19, 2019
    Assignee: Avent, Inc.
    Inventors: Alfred C. Coats, Louis Lupin
  • Patent number: 10098599
    Abstract: A colon imaging system, including an imaging capsule, having: a. a radiation source providing X-Ray and gamma radiation with energies sufficient to induce X-Ray fluorescence from nanoparticles that adhere to cancerous tissue, and which were administered to a patient in a solution prior to examining the colon with the imaging capsule; b. a detector for detecting particle energy of particles emitted responsive to the provided radiation and forming count information disclosing a number of particles detected for each energy level; c. a transceiver for transferring the count information to an external computer for analysis, and also having a computer for constructing images of an inside of the colon based on the count information; wherein the images provide an indication of locations in the colon of which the nanoparticles adhere to.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: October 16, 2018
    Assignee: CHECK-CAP LTD.
    Inventors: Yoav Kimchy, Shlomo Lewkowicz
  • Patent number: 10089728
    Abstract: Feature amount calculation unit determines that the diagnosis target is a bone portion of a subject, and calculates a feature amount of a density of the radiation image based on a soft region in a radiation image acquired by irradiating a photographic subject with radiation. An image processing unit performs image processing including gradation processing on the radiation image, such that the feature amount becomes the target density, to acquire a processed radiation image.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: October 2, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Keigo Nakamura, Tomoyuki Takahashi
  • Patent number: 10076307
    Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: September 18, 2018
    Assignee: Avent, Inc.
    Inventors: Alfred C. Coats, Louis Lupin
  • Patent number: 10022459
    Abstract: A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: July 17, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hideki Hayashi, Hirosuke Hatayama, Masanori Fujinami, Taro Toyota
  • Patent number: 10004475
    Abstract: Disclosed are embodiments of methods and devices for providing enhanced echogenicity to medical devices. The method includes rolling an impression roller having a plurality of protrusions and an outer surface against a medical device. The protrusions create depressions in the surface of the medical device. A guide roller forms a ridge of the depression into the depression to create a lobe. The lobe forms a pocket between a bottom surface of the depression and the lobe.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: June 26, 2018
    Assignee: Muffin Incorporated
    Inventor: Benjaman B. Quearry
  • Patent number: 9827268
    Abstract: The present invention provides a curable calcium phosphate composition for biological hard tissue repair that yields a cured product excellent in durability in a wet environment such as in a body or an oral cavity. The present invention relates to a curable calcium phosphate composition for biological hard tissue repair, including tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), calcium carbonate particles (C), and water (D), the curable calcium phosphate composition including 5 to 75 parts by weight of the tetracalcium phosphate particles (A), 10 to 70 parts by weight of the calcium hydrogen phosphate particles (B), and 2 to 50 parts by weight of the calcium carbonate particles (C) per 100 parts by weight of the total of the tetracalcium phosphate particles (A), the calcium hydrogen phosphate particles (B), and the calcium carbonate particles (C).
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: November 28, 2017
    Assignee: KURARAY NORITAKE DENTAL INC.
    Inventors: Kenji Hatanaka, Shumei Ishihara
  • Patent number: 9775904
    Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 3, 2017
    Assignee: SANOFI
    Inventors: Martin Bossart, Ralf Elvert, Andreas Evers, Torsten Haack, Siegfried Stengelin, Michael Wagner
  • Patent number: 9758561
    Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: September 12, 2017
    Assignee: SANOFI
    Inventors: Martin Bossart, Ralf Elvert, Andreas Evers, Torsten Haack, Siegfried Stengelin, Michael Wagner, Dieter Kadereit
  • Patent number: 9579380
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: February 28, 2017
    Assignee: NTT DENKO CORPORATION
    Inventor: Jonathan A. Eppstein
  • Patent number: 9351943
    Abstract: The present invention is directed to compositions and methods targeting tissue resident cells, such as fibroblasts, in a subject harboring conditions or at risk for conditions that would benefit from anti-fibroblastic therapy. The present invention relates to the use of fluorochemical compositions and methods of delivery that result in retention of the fluorochemical composition and any bioactive agent delivered in combination with the fluorochemical composition.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: May 31, 2016
    Inventor: Matthew T. McLeay
  • Patent number: 9340636
    Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer and an acrylate monomer. In one embodiment, the thiol monomer reacts with the vinyl sulfone monomer preferentially over the acrylate monomer, and this differential selectivity allows for the control of the architecture of crosslinking polymer network. The invention further includes a composition comprising an electrophilic monomer, a nucleophilic monomer, a nucleophilic catalyst and an acid, wherein the concentrations of the nucleophilic catalyst and acid are selected as to provide a specific induction time for the polymerization reaction of the composition.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: May 17, 2016
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christopher N. Bowman, Devatha P. Nair, Maciej Podgorski, Shunsuke Chatani
  • Patent number: 9244060
    Abstract: Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: January 26, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Roger Harrington
  • Patent number: 9161998
    Abstract: The invention relates to a method and a kit for preparing a radiopharmaceutical, the method comprising the steps: elution of a 68Ge/68Ga-Generator using hydrochloric acid as an eluent for obtaining a generator eluate comprising 68Gallium, feeding the generator eluate through a cation exchange cartridge, which collects the 68Gallium, separating the used eluent, eluting the 68Gallium from the cation exchange cartridge using a solution comprising sodium chloride and hydrochloric acid and feeding the resulting eluate into an aqueous precursor mixture comprising at least a labelling precursor thereby forming a reaction solution.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: October 20, 2015
    Assignee: Zentralklinik Bad Berka GmbH
    Inventor: Dirk Müller
  • Publication number: 20150147278
    Abstract: The present invention provides a prophylactic or therapeutic agent for various malignant tumors, including currently intractable solid tumors, which contains a novel antibody having the ability to bind to human LAT1/CD98 and inducing antibody-dependent cellular cytotoxicity specifically against cancer cells as an active ingredient.
    Type: Application
    Filed: December 5, 2014
    Publication date: May 28, 2015
    Applicants: Kinki University, Link Genomics, Inc.
    Inventors: Takashi Masuko, Shinichiro Niwa, Hidemi Hayashi, Dai Ogura, Takayuki Shindou
  • Patent number: 9040022
    Abstract: The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: May 26, 2015
    Assignee: Biosphere Medical, S.A.
    Inventor: Philippe Reb
  • Publication number: 20150139911
    Abstract: A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.
    Type: Application
    Filed: December 4, 2014
    Publication date: May 21, 2015
    Inventors: William P. Santamore, Jeanne M. Lesniak
  • Publication number: 20150139899
    Abstract: A method for diagnosing the development of a tissue injury in a subject comprising administering a sample of neoantibodies to the subject's tissue for the purpose of detecting the presence of neoepitopes bearing complement proteins.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventor: Rekha Bansal
  • Patent number: 9028802
    Abstract: The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially diagnosing Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: May 12, 2015
    Assignee: Koninklijke Philips N.V.
    Inventor: Frank Olaf Thiele
  • Publication number: 20150119835
    Abstract: Embodiments relate to an ophthalmology microscopy-system and a method of operating an ophthalmology microscopy-system which allow for an at least partial or full removal of liquids and gels used in ophthalmology for application in an eye of a patient in an particularly efficient way. Further embodiments relate to a product such as a liquid or a gel usable for an application in an eye of a patient, wherein the product has a high transmittance and, nevertheless, may be made visible particularly well.
    Type: Application
    Filed: October 27, 2014
    Publication date: April 30, 2015
    Inventors: Anja SEIWERT, Christoph HAUGER, Roland GUCKLER, Claude DE MOISSONNIER
  • Publication number: 20150118160
    Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.
    Type: Application
    Filed: January 6, 2015
    Publication date: April 30, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: Tracy Scott Anderson, Timothy E. Taylor
  • Patent number: 8992888
    Abstract: A contrast agent for angiography is disclosed, in particular, for examining animal or human bodies or components thereof such as members or organs thereof, comprising an essentially oil-based apolar contrast component for X-ray examinations, the contrast component having a contrast component viscosity in the range of 30-100 mPas. The contrast agent is characterized in that the contrast component is present in a mixture with at least one further apolar component, the viscosity of which is less than or at most equal to the contrast component viscosity. Methods for angiography examination are also disclosed, in which such a contrast agent or also a polar contrast agent are used at least periodically and applications of such contrast agents.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: March 31, 2015
    Assignee: Forim-X AG
    Inventors: Silke Grabherr, Erich Gygax
  • Patent number: 8986655
    Abstract: PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: March 24, 2015
    Assignee: The Regents of the University of California
    Inventors: Gregory A. Weiss, Jessica Arter, Juan E. Diaz
  • Publication number: 20150071852
    Abstract: In one embodiment, an isolated antibody or functional fragment thereof which binds an antigenic peptide sequence of human FOXC1 is provided herein. Such antibodies or functional fragments may be used to diagnose, prognose or treat basal-like breast cancer. The antibody or functional fragment may be a monoclonal antibody produced by a hybridoma cell line. Thus, a hybridoma cell line that produces a FOXC1 monoclonal antibody which binds an antigenic peptide sequence of human FOXC1 as described above is also provided.
    Type: Application
    Filed: April 10, 2014
    Publication date: March 12, 2015
    Applicant: John Wayne Cancer Institute
    Inventor: Xiaojiang Cui
  • Patent number: 8968703
    Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fructose and to an imaging medium containing hyperpolarised 13C-fructose for use in said method.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: March 3, 2015
    Assignees: GE Healthcare Limited, The Regents of the University of California
    Inventors: Albert Chen, David Wilson, John Kurhanewicz, Daniel Blackburn Vigneron, Kayvan Keshari
  • Patent number: 8961926
    Abstract: The invention relates to a method for targeting an imaging agent to cells of an animal to detect localized infections. More particularly, localized infections are detected by targeting imaging agents to inflammatory cells having receptors for a vitamin by using vitamin-imaging agent conjugates.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: February 24, 2015
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Walter Anthony Henne, Jr., Bindu Varghese, Ryan Rothenbuhler
  • Patent number: 8957215
    Abstract: The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: February 17, 2015
    Assignee: Navidea Biopharmaceuticals, Inc.
    Inventors: Ylva Gravenfors, Catrin Jonasson, Jonas Malmstrom, Gunnar Nordvall, David Pyring, Can Slivo, Daniel Sohn, Peter Strom, David Wensbo
  • Publication number: 20150044135
    Abstract: The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and differentiated cells of these intestinal metaplasias show high expression of CDH17 as well as other proteins. The invention also includes a clonal population of Barrett's esophagus stem cells as well as the stem cells of the surrounding normal epithelia and methods of using them for the detection, diagnosis, and treatment of Barrett's esophagus.
    Type: Application
    Filed: September 24, 2014
    Publication date: February 12, 2015
    Inventors: Wa Xian, Frank McKeon, Matthew Vincent, Khek Yu Ho
  • Publication number: 20150037250
    Abstract: According to one embodiment, a contrast agent includes a blood vessel contrast enhancement particles configured to enhance contrast of a blood vessel of an object and a diseased tissue contrast enhancement particles configured to enhance contrast of a diseased tissue of the object. The blood vessel contrast enhancement particles have a first particle size larger than a gap of vascular endothelial cells under an EPR effect. The diseased tissue contrast enhancement particles have a second particle size smaller than the gap.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Applicants: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Hitoshi YAMAGATA
  • Patent number: 8946412
    Abstract: This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: February 3, 2015
    Assignee: Danpet AB
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Tino Dyhring, Philip K. Ahring