X-ray Contrast Imaging Agent (e.g., Computed Tomography, Angiography, Etc.) Patents (Class 424/9.4)
  • Patent number: 10495968
    Abstract: A monomer having formula (I): wherein in formula (I), groups and variables are the same as described in the specification.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: December 3, 2019
    Assignee: ROHM AND HAAS ELECTRONIC MATERIALS LLC
    Inventors: Emad Aqad, James W. Thackeray, James F. Cameron
  • Patent number: 10485780
    Abstract: The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: November 26, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Shuo Wei, Xiao Zhen Zhou
  • Patent number: 10487037
    Abstract: A process for preparing an iodinated fatty acid ethyl ester includes steps of subjecting a fatty acid ester to a protonation reaction with phosphoric acid to form a protonated fatty acid ester, and subjecting the protonated fatty acid ester to an iodination reaction with an alkali metal iodide to obtain an iodinated fatty acid ester.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: November 26, 2019
    Assignee: Food Industry Research and Development Institute
    Inventors: Chih-Chiang Lin, Chih-Hong Tung, Yan-Hwa Chu, Ding-Yuan Su
  • Patent number: 10478512
    Abstract: The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: November 19, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Georgia State University Research Foundation Inc.
    Inventors: John V. Frangioni, Maged M. Henary
  • Patent number: 10311273
    Abstract: A thermal tag includes a power source to generate current along a resistive path and a plurality of infrared-emitting features positioned along the resistive path to emit infrared light along an infrared-emitting pattern, wherein the plurality of infrared-emitting features include one or more infrared-emitting stripes on a first surface of the thermal tag defining a pattern region and a plurality of infrared-emitting dots within a portion of the pattern region to provide a thermal-diffusion resistant pattern for activity monitoring.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: June 4, 2019
    Assignee: International Business Machines Corporation
    Inventors: Li-Wen Hung, Jui-Hsin Lai
  • Patent number: 10276735
    Abstract: A semiconductor nanocrystal include a first I-III-VI semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. Populations of the nanocrystals can have an emission FWHM of no greater than 0.35 eV.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: April 30, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Peter Matthew Allen, Moungi G. Bawendi
  • Patent number: 10231702
    Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 19, 2019
    Assignee: Avent, Inc.
    Inventors: Alfred C. Coats, Louis Lupin
  • Patent number: 10098599
    Abstract: A colon imaging system, including an imaging capsule, having: a. a radiation source providing X-Ray and gamma radiation with energies sufficient to induce X-Ray fluorescence from nanoparticles that adhere to cancerous tissue, and which were administered to a patient in a solution prior to examining the colon with the imaging capsule; b. a detector for detecting particle energy of particles emitted responsive to the provided radiation and forming count information disclosing a number of particles detected for each energy level; c. a transceiver for transferring the count information to an external computer for analysis, and also having a computer for constructing images of an inside of the colon based on the count information; wherein the images provide an indication of locations in the colon of which the nanoparticles adhere to.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: October 16, 2018
    Assignee: CHECK-CAP LTD.
    Inventors: Yoav Kimchy, Shlomo Lewkowicz
  • Patent number: 10089728
    Abstract: Feature amount calculation unit determines that the diagnosis target is a bone portion of a subject, and calculates a feature amount of a density of the radiation image based on a soft region in a radiation image acquired by irradiating a photographic subject with radiation. An image processing unit performs image processing including gradation processing on the radiation image, such that the feature amount becomes the target density, to acquire a processed radiation image.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: October 2, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Keigo Nakamura, Tomoyuki Takahashi
  • Patent number: 10076307
    Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: September 18, 2018
    Assignee: Avent, Inc.
    Inventors: Alfred C. Coats, Louis Lupin
  • Patent number: 10022459
    Abstract: A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: July 17, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hideki Hayashi, Hirosuke Hatayama, Masanori Fujinami, Taro Toyota
  • Patent number: 10004475
    Abstract: Disclosed are embodiments of methods and devices for providing enhanced echogenicity to medical devices. The method includes rolling an impression roller having a plurality of protrusions and an outer surface against a medical device. The protrusions create depressions in the surface of the medical device. A guide roller forms a ridge of the depression into the depression to create a lobe. The lobe forms a pocket between a bottom surface of the depression and the lobe.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: June 26, 2018
    Assignee: Muffin Incorporated
    Inventor: Benjaman B. Quearry
  • Patent number: 9827268
    Abstract: The present invention provides a curable calcium phosphate composition for biological hard tissue repair that yields a cured product excellent in durability in a wet environment such as in a body or an oral cavity. The present invention relates to a curable calcium phosphate composition for biological hard tissue repair, including tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), calcium carbonate particles (C), and water (D), the curable calcium phosphate composition including 5 to 75 parts by weight of the tetracalcium phosphate particles (A), 10 to 70 parts by weight of the calcium hydrogen phosphate particles (B), and 2 to 50 parts by weight of the calcium carbonate particles (C) per 100 parts by weight of the total of the tetracalcium phosphate particles (A), the calcium hydrogen phosphate particles (B), and the calcium carbonate particles (C).
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: November 28, 2017
    Assignee: KURARAY NORITAKE DENTAL INC.
    Inventors: Kenji Hatanaka, Shumei Ishihara
  • Patent number: 9775904
    Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 3, 2017
    Assignee: SANOFI
    Inventors: Martin Bossart, Ralf Elvert, Andreas Evers, Torsten Haack, Siegfried Stengelin, Michael Wagner
  • Patent number: 9758561
    Abstract: The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: September 12, 2017
    Assignee: SANOFI
    Inventors: Martin Bossart, Ralf Elvert, Andreas Evers, Torsten Haack, Siegfried Stengelin, Michael Wagner, Dieter Kadereit
  • Patent number: 9579380
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: February 28, 2017
    Assignee: NTT DENKO CORPORATION
    Inventor: Jonathan A. Eppstein
  • Patent number: 9351943
    Abstract: The present invention is directed to compositions and methods targeting tissue resident cells, such as fibroblasts, in a subject harboring conditions or at risk for conditions that would benefit from anti-fibroblastic therapy. The present invention relates to the use of fluorochemical compositions and methods of delivery that result in retention of the fluorochemical composition and any bioactive agent delivered in combination with the fluorochemical composition.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: May 31, 2016
    Inventor: Matthew T. McLeay
  • Patent number: 9340636
    Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer and an acrylate monomer. In one embodiment, the thiol monomer reacts with the vinyl sulfone monomer preferentially over the acrylate monomer, and this differential selectivity allows for the control of the architecture of crosslinking polymer network. The invention further includes a composition comprising an electrophilic monomer, a nucleophilic monomer, a nucleophilic catalyst and an acid, wherein the concentrations of the nucleophilic catalyst and acid are selected as to provide a specific induction time for the polymerization reaction of the composition.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: May 17, 2016
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christopher N. Bowman, Devatha P. Nair, Maciej Podgorski, Shunsuke Chatani
  • Patent number: 9244060
    Abstract: Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: January 26, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Roger Harrington
  • Patent number: 9161998
    Abstract: The invention relates to a method and a kit for preparing a radiopharmaceutical, the method comprising the steps: elution of a 68Ge/68Ga-Generator using hydrochloric acid as an eluent for obtaining a generator eluate comprising 68Gallium, feeding the generator eluate through a cation exchange cartridge, which collects the 68Gallium, separating the used eluent, eluting the 68Gallium from the cation exchange cartridge using a solution comprising sodium chloride and hydrochloric acid and feeding the resulting eluate into an aqueous precursor mixture comprising at least a labelling precursor thereby forming a reaction solution.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: October 20, 2015
    Assignee: Zentralklinik Bad Berka GmbH
    Inventor: Dirk Müller
  • Publication number: 20150147278
    Abstract: The present invention provides a prophylactic or therapeutic agent for various malignant tumors, including currently intractable solid tumors, which contains a novel antibody having the ability to bind to human LAT1/CD98 and inducing antibody-dependent cellular cytotoxicity specifically against cancer cells as an active ingredient.
    Type: Application
    Filed: December 5, 2014
    Publication date: May 28, 2015
    Applicants: Kinki University, Link Genomics, Inc.
    Inventors: Takashi Masuko, Shinichiro Niwa, Hidemi Hayashi, Dai Ogura, Takayuki Shindou
  • Patent number: 9040022
    Abstract: The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: May 26, 2015
    Assignee: Biosphere Medical, S.A.
    Inventor: Philippe Reb
  • Publication number: 20150139911
    Abstract: A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.
    Type: Application
    Filed: December 4, 2014
    Publication date: May 21, 2015
    Inventors: William P. Santamore, Jeanne M. Lesniak
  • Publication number: 20150139899
    Abstract: A method for diagnosing the development of a tissue injury in a subject comprising administering a sample of neoantibodies to the subject's tissue for the purpose of detecting the presence of neoepitopes bearing complement proteins.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventor: Rekha Bansal
  • Patent number: 9028802
    Abstract: The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially diagnosing Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: May 12, 2015
    Assignee: Koninklijke Philips N.V.
    Inventor: Frank Olaf Thiele
  • Publication number: 20150119835
    Abstract: Embodiments relate to an ophthalmology microscopy-system and a method of operating an ophthalmology microscopy-system which allow for an at least partial or full removal of liquids and gels used in ophthalmology for application in an eye of a patient in an particularly efficient way. Further embodiments relate to a product such as a liquid or a gel usable for an application in an eye of a patient, wherein the product has a high transmittance and, nevertheless, may be made visible particularly well.
    Type: Application
    Filed: October 27, 2014
    Publication date: April 30, 2015
    Inventors: Anja SEIWERT, Christoph HAUGER, Roland GUCKLER, Claude DE MOISSONNIER
  • Publication number: 20150118160
    Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.
    Type: Application
    Filed: January 6, 2015
    Publication date: April 30, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: Tracy Scott Anderson, Timothy E. Taylor
  • Patent number: 8992888
    Abstract: A contrast agent for angiography is disclosed, in particular, for examining animal or human bodies or components thereof such as members or organs thereof, comprising an essentially oil-based apolar contrast component for X-ray examinations, the contrast component having a contrast component viscosity in the range of 30-100 mPas. The contrast agent is characterized in that the contrast component is present in a mixture with at least one further apolar component, the viscosity of which is less than or at most equal to the contrast component viscosity. Methods for angiography examination are also disclosed, in which such a contrast agent or also a polar contrast agent are used at least periodically and applications of such contrast agents.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: March 31, 2015
    Assignee: Forim-X AG
    Inventors: Silke Grabherr, Erich Gygax
  • Patent number: 8986655
    Abstract: PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: March 24, 2015
    Assignee: The Regents of the University of California
    Inventors: Gregory A. Weiss, Jessica Arter, Juan E. Diaz
  • Publication number: 20150071852
    Abstract: In one embodiment, an isolated antibody or functional fragment thereof which binds an antigenic peptide sequence of human FOXC1 is provided herein. Such antibodies or functional fragments may be used to diagnose, prognose or treat basal-like breast cancer. The antibody or functional fragment may be a monoclonal antibody produced by a hybridoma cell line. Thus, a hybridoma cell line that produces a FOXC1 monoclonal antibody which binds an antigenic peptide sequence of human FOXC1 as described above is also provided.
    Type: Application
    Filed: April 10, 2014
    Publication date: March 12, 2015
    Applicant: John Wayne Cancer Institute
    Inventor: Xiaojiang Cui
  • Patent number: 8968703
    Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fructose and to an imaging medium containing hyperpolarised 13C-fructose for use in said method.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: March 3, 2015
    Assignees: GE Healthcare Limited, The Regents of the University of California
    Inventors: Albert Chen, David Wilson, John Kurhanewicz, Daniel Blackburn Vigneron, Kayvan Keshari
  • Patent number: 8961926
    Abstract: The invention relates to a method for targeting an imaging agent to cells of an animal to detect localized infections. More particularly, localized infections are detected by targeting imaging agents to inflammatory cells having receptors for a vitamin by using vitamin-imaging agent conjugates.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: February 24, 2015
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Walter Anthony Henne, Jr., Bindu Varghese, Ryan Rothenbuhler
  • Patent number: 8957215
    Abstract: The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: February 17, 2015
    Assignee: Navidea Biopharmaceuticals, Inc.
    Inventors: Ylva Gravenfors, Catrin Jonasson, Jonas Malmstrom, Gunnar Nordvall, David Pyring, Can Slivo, Daniel Sohn, Peter Strom, David Wensbo
  • Publication number: 20150044135
    Abstract: The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and differentiated cells of these intestinal metaplasias show high expression of CDH17 as well as other proteins. The invention also includes a clonal population of Barrett's esophagus stem cells as well as the stem cells of the surrounding normal epithelia and methods of using them for the detection, diagnosis, and treatment of Barrett's esophagus.
    Type: Application
    Filed: September 24, 2014
    Publication date: February 12, 2015
    Inventors: Wa Xian, Frank McKeon, Matthew Vincent, Khek Yu Ho
  • Publication number: 20150037250
    Abstract: According to one embodiment, a contrast agent includes a blood vessel contrast enhancement particles configured to enhance contrast of a blood vessel of an object and a diseased tissue contrast enhancement particles configured to enhance contrast of a diseased tissue of the object. The blood vessel contrast enhancement particles have a first particle size larger than a gap of vascular endothelial cells under an EPR effect. The diseased tissue contrast enhancement particles have a second particle size smaller than the gap.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Applicants: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Hitoshi YAMAGATA
  • Patent number: 8946412
    Abstract: This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: February 3, 2015
    Assignee: Danpet AB
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Tino Dyhring, Philip K. Ahring
  • Patent number: 8936809
    Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: January 20, 2015
    Assignee: Lidds AB
    Inventors: Hans Lennernäs, Bo Lennernäs, Jonas Hugosson, Niklas Axén
  • Publication number: 20150011947
    Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.
    Type: Application
    Filed: December 19, 2013
    Publication date: January 8, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: Tracy Scott Anderson, Timothy E. Taylor
  • Publication number: 20150004097
    Abstract: The present invention provides targeted delivery compositions and methods of using the compositions for treating and diagnosing a disease state in a subject.
    Type: Application
    Filed: September 18, 2014
    Publication date: January 1, 2015
    Inventors: Thomas E. Rogers, John N. Freskos
  • Patent number: 8920780
    Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
    Type: Grant
    Filed: July 4, 2008
    Date of Patent: December 30, 2014
    Assignee: GE Healthcare AS
    Inventor: Mikkel Thaning
  • Publication number: 20140369940
    Abstract: Provided are anti-human ?-synuclein-specific binding molecules, e.g., antibodies or antigen-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human ?-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human ?-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for ?-synuclein targeted immunotherapy and diagnosis, respectively.
    Type: Application
    Filed: June 22, 2012
    Publication date: December 18, 2014
    Applicants: University of Zurich, Biogen IDEC International Neuroscience GmbH
    Inventors: Andreas Weihofen, Jan Grimm, Cristoph Hock, Roger Nitsch, Lihe Su, Paul Weinreb
  • Publication number: 20140363377
    Abstract: The invention provides compositions and method for delivering a therapeutic or diagnostic agent to a disease site in a mammal, the method comprising administering to the mammal a therapeutically or diagnostically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises the therapeutic or diagnostic agent coupled to a Procaspase 8 polypeptide and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 11, 2014
    Inventor: Isabella TAI
  • Publication number: 20140363378
    Abstract: Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles in the circulation into cylindrical nanofibers in the acidic extracellular environment of tumors which can be used to achieve a higher relative concentration of imaging, drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.
    Type: Application
    Filed: February 1, 2013
    Publication date: December 11, 2014
    Inventors: Joshua E. Goldberger, Michael F. Tweedle
  • Patent number: 8906346
    Abstract: Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: December 9, 2014
    Assignee: Hanwha Chemical Corporation
    Inventors: Ju Young Park, Wan Jae Myeong, Bong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Taeghwan Hyeon, Daishun Ling
  • Patent number: 8901276
    Abstract: The present invention is directed to peptide reagents, methods for detecting colon pre-cancer (dysplasia with non-polypoid or polypoid morphology) or cancer using the peptide reagents, and methods for targeting pre-cancerous or cancerous colon cells using the peptide reagents.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: December 2, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Thomas D. Wang, Sharon Miller, Bishnu Joshi
  • Publication number: 20140348752
    Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.
    Type: Application
    Filed: December 10, 2013
    Publication date: November 27, 2014
    Inventor: Anthony Quinn
  • Patent number: 8894968
    Abstract: The invention relates to pharmaceutical agents containing a particulate inorganic matrix having a diameter of from 0.1 nm to 100 ?m, preferably 1 nm to 10 ?m, particularly preferably 1 nm to 1 ?m, such as, for example, topaz, (Al2F2)[SiO4], and chiolite, Na[Al3F4], preferably wavellite, Al3(PO4)2(OH,F)2, calcium carbonate, CaCO3, maghemite, ?-Fe2O3, particularly preferably zeolites, gen. formula Mn[(AlO2)x(SiO2)y] (M=metal, e.g.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 25, 2014
    Assignee: nanoPET Pharma GmbH
    Inventor: Kristian Schilling
  • Patent number: 8889102
    Abstract: The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO).
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: November 18, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Vanda A. Lennon, Sean J. Pittock
  • Publication number: 20140335015
    Abstract: The present invention relates to novel nanoparticles which can be advantageously used in the health sector as diagnostic and/or therapeutic agents. Nanoparticles of the invention comprise a metallic material at least partly covered with an hafnium oxide material or embedded therein. When compared to existing products, these nanoparticles offer a remarkable benefit over risk ratio. Specifically, these nanoparticles potentiate the efficiency of known metallic nanoparticles. Indeed, they retain the metal intrinsic properties and are now in addition safely usable in a mammal, in particular in a human being. The invention also relates to methods for producing said nanoparticles, to compositions containing same, and to uses thereof.
    Type: Application
    Filed: December 17, 2012
    Publication date: November 13, 2014
    Inventors: Agnes Pottier, Laurent Levy, Marie-Edith Meyre
  • Patent number: 8877158
    Abstract: It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent to accumulate in the neovascular site. The present invention provides a targeting agent to a neovascular site, which comprises a gelatin-like protein.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 4, 2014
    Assignees: FUJIFILM Corporation, Kyoto University
    Inventors: Kentaro Nakamura, Yasuhiko Tabata