Two Or More Halogenated Benzene Rings In The Same Compound Patents (Class 424/9.451)
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Patent number: 9115230Abstract: The invention concerns a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a PVA having covalently grafted thereon iodinated benzyl groups comprising 1-4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0-100% hydrolyzed PVA with a iodinated benzyl derivative comprising 1-4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo-benzylether-PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo-benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor.Type: GrantFiled: March 9, 2011Date of Patent: August 25, 2015Assignees: ANTIA THERAPEUTICS S.A., UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Yves Chevalier, Géraldine Agusti, Coralie Nyffenegger, Eric Doelker, Olivier Jordan, Gert Andersen
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Patent number: 8470296Abstract: New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation.Type: GrantFiled: March 8, 2007Date of Patent: June 25, 2013Assignee: Provectus Pharmatech, Inc.Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
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Patent number: 8202511Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: GrantFiled: October 10, 2008Date of Patent: June 19, 2012Assignee: GE Healthcare ASInventors: Ian Martin Newington, Duncan George Wynn, Veronique Morisson-Iveson, Joanna Marie Passmore
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Patent number: 8147805Abstract: Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.Type: GrantFiled: January 5, 2006Date of Patent: April 3, 2012Assignee: The Board of Regents of The University of T exas SystemInventors: David Yang, Dongfang Yu, Mithu Chanda, Ali Azhdarinia, Changsok Oh, E. Edmund Kim
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Patent number: 8066974Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: GrantFiled: May 10, 2007Date of Patent: November 29, 2011Assignee: GE Healthcare ASInventors: Duncan Wynn, Harry John Wadsworth, Ian Martin Newington
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Publication number: 20110008263Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CO—CH3)—X—N(CO—CH3)—R and salts or optical active isomers thereof, wherein X denotes a C3 to C4 straight or branched alkylene moiety wherein the alkylene moiety is substituted by one or two hydroxyl groups, optionally hydroxylated alkyl groups and/or alkoxy groups; and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.Type: ApplicationFiled: February 26, 2009Publication date: January 13, 2011Inventors: Hanno Priebe, Audun Aukrust
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Publication number: 20100303734Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds.Type: ApplicationFiled: December 4, 2008Publication date: December 2, 2010Inventor: Veronique Morisson-Iveson
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Patent number: 7713517Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.Type: GrantFiled: April 21, 2004Date of Patent: May 11, 2010Assignee: Marval Biosciences, Inc.Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi
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Patent number: 7666390Abstract: The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More particularly, the present invention relates to DTPA derivatives, which contain iodine and are useful as contrast agents for diagnosing renal function, metal complexes of the DTPA derivatives with 99mTc, 166Ho, 111In, 90Y, 153Sm, 186Re, 188Re, 68Ga, or 177Lu, which are useful as liquid radiation sources for treating vascular stenosis and contrast agents for diagnosing renal function, and radiation sources and contrast agents including the metal complexes. The DTPA derivatives and metal complexes thereof are safe because the metal complexes are excreted via the kidneys and bladder within several minutes from the time of use as liquid radiation sources for treating vascular stenosis, and are cost-effective because they are potentially useful as contrast agents and as agents for diagnosing renal function.Type: GrantFiled: April 25, 2006Date of Patent: February 23, 2010Assignee: Korea Atomic Energy Research InstituteInventors: Young-Don Hong, Sun-Ju Choi, Ok Ja Choi
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Patent number: 7588751Abstract: A method of pereparing a rediographic contrast medium containing liposomes is disclosed, comprising (a) dissolving a phospholipid and a sterol in a supercritical or subcritical carbon dioxide in the presence of a compound containing a hydroxyl group or a polyalkyleneoxide group, (b) adding thereto an aqueous solution containing an iodine compound to form micelles and (c) discharging the carbon dioxide to form liposomal vesicles enclosing the iodine compound.Type: GrantFiled: July 13, 2005Date of Patent: September 15, 2009Assignee: Konica Minolta Medical & Graphic, Inc.Inventors: Eiichi Ueda, Akihisa Nakajima, Chiaki Nagaike, Yasuyuki Motokui
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Contrast agents to improve gastrointestinal tract opacification during abdominal and pelvic CT scans
Patent number: 7582283Abstract: Methods of imaging a portion of a body of a patient are provided. In the methods, a contrast agent including an iso-osmotic contrast agent is administered to the patient. In a preferred embodiment, the iso-osmotic contrast agent comprises polyethylene glycol (PEG) and electrolytes, which make the PEG iso-osmotic. In a preferred embodiment, a positive contrast agent, such as an iodine-based contrast agent, is added to the PEG. The iso-osmotic contrast agent can be administered in volumes that are lower than previous contrast agents. The iso-osmotic contrast agent can be administered in combination with a positive intravenous contrast agent. At least one image of the portion of the patient's body is obtained, such as by computed tomography, after the contrast agent is administered. The methods can be used to image a pelvis, GI tract, and/or appendix of the patient. Iso-osmotic contrast agents are also provided.Type: GrantFiled: March 5, 2004Date of Patent: September 1, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Andrew J. Taylor, Jeffrey J. Hebert, Thomas C. Winter, III -
Patent number: 7485753Abstract: The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: GrantFiled: December 1, 2006Date of Patent: February 3, 2009Assignee: GE Healthcare ASInventors: Lars-Goran Wistrand, Mikkel Thaning, Oskar Axelsson, Sven Andersson
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Patent number: 7427389Abstract: New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.Type: GrantFiled: February 3, 2005Date of Patent: September 23, 2008Assignee: Provectus Pharmatech, Inc.Inventors: Timothy C. Scott, H. Craig Dees, Eric A. Wachter
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Patent number: 7338652Abstract: New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.Type: GrantFiled: February 3, 2005Date of Patent: March 4, 2008Assignee: Provectus Pharmatech, Inc.Inventors: Timothy C. Scott, H. Craig Dees, Eric A. Wachter
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Publication number: 20070264201Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing hydroxyl groups allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to methods employing such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: May 10, 2007Publication date: November 15, 2007Inventors: Duncan Wynn, Gareth Humphries
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Publication number: 20070134163Abstract: The present invention discloses a radiographic contrasting agent containing multiple aromatic groups, each of which is substituted with at least three halogen atoms. The radiographic contrasting agent can initiate a polymerization process. The present invention also discloses a radio-opaque polymeric material that comprises a biodegradable polymer having at least one radiographic contrasting moiety covalently attached thereto. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.Type: ApplicationFiled: December 13, 2005Publication date: June 14, 2007Inventor: Jonathon Zhao
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Publication number: 20070128120Abstract: The present invention discloses an organic radiographic contrasting agent containing an aliphatic or alicyclic backbone and multiple halogen-substituted aromatic groups. Each of the halogen-substituted aromatic groups in the radiographic contrasting agent is substituted with at least three halogen atoms and is covalently attached to the aliphatic or alicyclic backbone. The present invention also discloses a radio-opaque polymeric material comprising the radiographic contrasting agent and at least one polymer. The radiographic contrasting agent is physically admixed with the at least one polymer or physically embedded or dispersed in the at least one polymer. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.Type: ApplicationFiled: December 7, 2005Publication date: June 7, 2007Inventor: Jonathon Zhao
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Publication number: 20060002858Abstract: The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to exist in an aggregated state that is greater in increased concentrations. In this aggregated state, contrast media assume the role of multivalent antigens and can successfully compete with any other antigens involved in antibody-antigen reactions that lead to anaphylaxis. In this competition, the large quantity of contrast media serves to inhibit the adverse effects of antibody-antigen reactions without the contrast media itself creating antibodies or creating toxicity problems.Type: ApplicationFiled: September 1, 2005Publication date: January 5, 2006Inventor: Elliott Lasser
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Publication number: 20050002864Abstract: A compound represented by the following general formula (I) or a salt thereof: wherein Ar1 and Ar2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L1 and L2 independently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents —CH(OH)— or —CO—, which is suitable for an iodine-containing contrast medium containing liposomes.Type: ApplicationFiled: August 22, 2002Publication date: January 6, 2005Inventors: Kazunobu Takahashi, Hiroshi Kitaguchi, Kazuhiro Aikawa
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Publication number: 20040191175Abstract: Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.Type: ApplicationFiled: March 9, 2004Publication date: September 30, 2004Applicant: Rutgers University - Department of ChemistryInventors: Joachim B. Kohn, Durgadas Bolikal, Sanyog M. Pendharkar
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Publication number: 20040086461Abstract: Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.Type: ApplicationFiled: October 23, 2003Publication date: May 6, 2004Applicant: Rutgers University - Department of ChemistryInventors: Joachim B. Kohn, Durgadas Bolikal, Sanyog M. Pendharkar
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Publication number: 20040086462Abstract: Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.Type: ApplicationFiled: October 23, 2003Publication date: May 6, 2004Applicant: Rutgers University - Department of ChemistryInventors: Joachim B. Kohn, Durgadas Bolikal, Sanyog M. Pendharkar
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Publication number: 20040037778Abstract: Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.Type: ApplicationFiled: November 5, 2002Publication date: February 26, 2004Inventors: Joachim B. Kohn, Durgadas Bolikal, Sanyog M. Pendharkar
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Patent number: 6599448Abstract: The present invention provides a radio-opaque composition including a polymer or monomer, wherein the polymer or monomer has a non-leachable radio-opaque moiety. The non-leachable radio-opaque moiety is covalently attached to the polymer or monomer.Type: GrantFiled: May 10, 2000Date of Patent: July 29, 2003Assignee: Hydromer, Inc.Inventors: Joseph A. Ehrhard, Jr., Patrick Hennessey
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Patent number: 6509406Abstract: The invention provides X-ray contrastable plastics materials with low-molecular weight iodine compounds, a process for preparing X-ray contrastable plastics materials with low molecular weight iodine compounds, the use of low molecular weight iodine compounds to improve the X-ray contrast in transparent plastics materials and toys with improved X-ray contrast containing low molecular weight iodine compounds.Type: GrantFiled: June 1, 2001Date of Patent: January 21, 2003Assignee: Bayer AktiengesellschaftInventors: Axel Brenner, Martin Döbler, Michael Prein
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Publication number: 20020040162Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.Type: ApplicationFiled: May 25, 2001Publication date: April 4, 2002Inventors: Don A. Gabriel, Laura J. Melton
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Publication number: 20020031475Abstract: The invention relates to the use of intravenous contrast agents for projection mammography and novel devices for carrying out projection mammography. The invention therefore relates to the use of intravenous contrast agents for producing a diagnostic medium for projection mammography. With the additional intravenous administration of contrast agent, projection mammography attains a sensitivity comparable to the most modern methods, such as magnetic resonance tomography (MRT) while having a wider range of applications and avoiding the cost of MRT. This novel method is simple and can be carried out without special inconvenience for the patients. It a) considerably improves sensitivity for demonstrating focal lesions in the mammae and b) provides additional information on the character of previously detected lesions.Type: ApplicationFiled: April 17, 2000Publication date: March 14, 2002Inventors: ULRICH SPECK, IRTEL VON BRENNDORFF
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Patent number: RE45195Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.Type: GrantFiled: February 15, 2013Date of Patent: October 14, 2014Assignees: Marval Pharma, Inc., Case Western Reserve University, Cleveland State UniversityInventors: Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi, Chen-Yu Kao