Pediatric Patents (Class 426/801)
  • Patent number: 8975299
    Abstract: The subject invention thus provides a composition comprising at least one triglyceride, at least one phospholipid and at least one poly-unsaturated fatty acids (LC-PUFA); wherein at least about 1% of the LC-PUFA in the composition is conjugated to said at least one phospholipid and uses thereof.
    Type: Grant
    Filed: November 2, 2008
    Date of Patent: March 10, 2015
    Assignee: Enzymotec Ltd.
    Inventors: Fabiana Bar Yosef, Dori Pollod, Ariel Katz
  • Patent number: 8859029
    Abstract: The invention relates to a kit of parts comprising 2 to 100 containers each containing an infant formula, wherein each infant formula is in a form suitable for administration to an infant and/or toddler or in a form suitable for administration to an infant and/or toddler after admixing with an aqueous liquid, wherein the kit of part comprises at least two different infant formulas which differ from each other in taste and/or flavor by having a different protein fraction or by being a fermented infant formula, wherein each of the different protein fractions is selected from the group consisting of intact milk proteins including cow milk proteins, intact plant proteins including soy protein, hydrolysed proteins, free amino acids, or mixtures of two or more thereof. The invention further relates to the use of such kit of parts for stimulating the acceptance and/or liking of a broad range of fruits, vegetables and/or whole grain cereal products by infants and/or toddlers or later in life.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 14, 2014
    Assignee: N.V. Nutricia
    Inventors: Hugo Weenen, Martine Sandra Alles
  • Patent number: 8841097
    Abstract: An edible oil obtained by culturing a microorganism belong to the genus Mortierella subgenus Mortierella in a medium containing a nitrogen source derived from soybean is discussed. The oils obtained have a low 24,25-methylenecholest-5-en-3?-ol content.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: September 23, 2014
    Assignee: Suntory Holdings Limited
    Inventors: Kenichi Higashiyama, Kengo Akimoto, Sakayu Shimizu
  • Patent number: 8815279
    Abstract: A method is provided for reducing the extent of or occurrence of long-term adverse health effects in human infants, comprising feeding to said infants when newborn a nutrient-containing-formula providing not more than 1 gram of protein per 100 ml of formula and/or not more than 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of obesity or atherosclerosis in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: August 26, 2014
    Assignee: University College London
    Inventors: Atul Singhal, Alan Lucas
  • Patent number: 8715769
    Abstract: The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: May 6, 2014
    Assignee: N.V. Nutricia
    Inventors: Joachim Schmitt, Bernd Stahl, Jan Knol
  • Patent number: 8652553
    Abstract: A method, device, and knife system for producing purëed, cooked foodstuffs from piece-form raw material. The method includes pre-chopping of the piece-form raw material in a pre-chopping unit, cooking of the pre-chopped raw material in a cooking plant, and final processing of the cooked product in a final-processing unit. Before cooking, the piece-form raw material is cut into small pieces by the pre-chopping unit such that a pumpable mass is produced from the piece-form raw material.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: February 18, 2014
    Assignee: Stephan Machinery GmbH
    Inventors: Dorothee Kloepping, Gerhard Brockmann, Henry Rose
  • Patent number: 8628921
    Abstract: The disclosure is related generally to methods for testing mammary fluid (including milk) to establish or confirm the identity of the donor of the mammary fluid. Such methods are useful in the milk-bank business to improve safety.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: January 14, 2014
    Assignee: Prolacta Bioscience Inc.
    Inventors: Elena M. Medo, Martin L. Lee, David J. Rechtman
  • Patent number: 8557320
    Abstract: The present invention is directed to a novel method for increasing the production of acetate, decreasing the production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut of a formula-fed infant. The method comprises administration of a therapeutically effective amount of PDX to the infant.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: October 15, 2013
    Assignee: Mead Johnson Nutrition Company
    Inventors: Bryon W. Petschow, Robert J. McMahon, Glenn R. Gibson, Robert A. Rastall, Renia Gemmell, Maria Saarela, Anna-Marja Aura
  • Patent number: 8293264
    Abstract: A nutritional formula which includes a lipid or fat; a protein source; about 5 to about 100 mg/100 kcal of a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; about 0.1 to about 1 mg/100 kcal of a prebiotic composition, wherein the prebiotic composition comprises at least 20% of an oligosaccharide which comprises galacto-oligosaccharide; and about 0.015 to about 0.1 (pg/?g) ppm of TGF-?.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: October 23, 2012
    Assignee: Mead Johnson Nutrition Company
    Inventors: Francisco J. Rosales, Eric van Tol, Gyan P. Rai, Dirk Hondmann, Kristin Morris, Dattatreya Banavara, Zeina E. Jouni, Robert J. McMahon, Deborah A. Schade, Donald Carey Walker
  • Patent number: 8278046
    Abstract: The disclosure is related generally to methods for testing mammary fluid (including milk) to establish or confirm the identity of the donor of the mammary fluid. Such methods are useful in the milk-bank business to improve safety.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: October 2, 2012
    Assignee: Prolacta Bioscience
    Inventors: Elena M. Medo, Martin L. Lee, David J. Rechtman
  • Patent number: 8277863
    Abstract: The present invention is directed to a novel method for increasing the production of acetate, decreasing the production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut of a formula-fed infant. The method comprises administration of a therapeutically effective amount of PDX to the infant.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: October 2, 2012
    Assignee: Mead Johnson Nutrition Company
    Inventors: Bryon W. Petschow, Robert J. McMahon, Glenn R. Gibson, Robert A. Rastall, Renia Gemmell, Maria Saarela, Anna-Marja Aura
  • Patent number: 8263147
    Abstract: Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg/liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg/liter of lutein. The formulas may further comprise docosahexaenoic acid.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: September 11, 2012
    Assignee: Abbott Laboratories
    Inventors: Bridget Barrett-Reis, Pamela T. Price, Amy Mackey
  • Patent number: 8110177
    Abstract: Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: February 7, 2012
    Assignee: Cedars-Sinai Medical Center
    Inventors: Henry C. Lin, Mark Pimentel
  • Patent number: 8101227
    Abstract: The present invention is aimed to retain the taste and texture of infant and toddler food products that have been frozen. By employing a slow-churning freezing process, the frozen infant and toddler products are lighter in color, smoother and creamier in texture and possess a better taste profile. The invention further comprises methods of making and using such products.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: January 24, 2012
    Assignee: Nestec S.A.
    Inventor: Leighanne Higgins
  • Patent number: 8067356
    Abstract: The present invention relates to a nutritional composition which is liquid and shelf-stable or powdered and reconstitutable. The composition has a fiber content of more than 2.5 g/fibber per 100 ml of the composition. Furthermore, it has an energy content of 1.3-1.8 kcal/ml. The composition is useful to improve and maintain gut comfort, restoring a well-balanced gut flora, especially in an elderly patient prone to malnutrition. The invention further relates to a process for preparing the nutritional composition.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: November 29, 2011
    Assignee: Nestec S.A.
    Inventors: Christina Ammann, Florence Rochat, Claudia Roessle
  • Patent number: 8021708
    Abstract: The present invention is directed to a novel method for increasing the production of acetate, decreasing the production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut of a formula-fed infant. The method comprises administration of a therapeutically effective amount of PDX to the infant.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: September 20, 2011
    Assignee: Mead Johnson Nutrition Company
    Inventors: Byron W. Petschow, Robert J. McMahon, Glenn R. Gibson, Robert A. Rastall, Renia Gemmell, Maria Saarela, Anna-Marja Aura
  • Patent number: 8007847
    Abstract: A device for preparing a fluid food at a desired consumption temperature on demand, comprising two reservoirs of water, a container containing a formula, a data processor and a controller for dispensing water of the correct temperature from each of the reservoirs and the formula from the container into a vessel. Also provided are methods for preparing specialized foods at desired consumption temperatures on demand, and methods for marketing both foods and food-preparation devices.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: August 30, 2011
    Inventors: Eytan Biderman, Noam Ziv
  • Patent number: 7998501
    Abstract: Disclosed are newborn infant formulas comprising fat, carbohydrate, and from 0.5 to 2.5 g of protein per 100 ml of formula, wherein the formula has a caloric density of from 25 to 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to provide newborns with optimal nutrition, to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of atherosclerosis or coronary artery disease in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: August 16, 2011
    Assignee: University College London
    Inventors: Atul Singhal, Alan Lucas
  • Patent number: 7829126
    Abstract: Disclosed are infant formulas and corresponding methods of using them to promote retinal health and vision development in infants. The formulas, which are free of egg phospholipids and comprise fat, protein, carbohydrate, vitamins, and minerals, including docosahexaenoic acid and, on a ready-to-feed basis, at least about 50 mcg/liter of lutein, wherein the weight ratio of lutein (mcg) to docosahexaenoic acid (mg) is from about 1:2 to about 10:1. The formulas are also believed to be especially useful in reducing the risk of retinopathy of prematurity in preterm infants.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: November 9, 2010
    Assignee: Abbott Laboratories
    Inventors: Bridget Barrett-Reis, Pamela T. Price, Amy Mackey
  • Patent number: 7824727
    Abstract: A novel food composition is provided in which omega-3 fatty acids, preferably including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), particularly in the form of fish oil, is provided in a liquid egg product.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: November 2, 2010
    Assignee: Burnbrae Farms Limited
    Inventors: Margaret F. Hudson, Phillip Lee Wing, Elyse Beauregard
  • Patent number: 7799365
    Abstract: A novel food composition is provided in which omega-3 fatty acids, preferably including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), particularly in the form of fish oil, is provided in a liquid egg product.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: September 21, 2010
    Assignee: BurnBrae Farms Limited
    Inventors: Margaret F. Hudson, Phillip Lee Wing, Elyse Beauregard
  • Patent number: 7790209
    Abstract: The invention provides a total enteral nutritious composition containing proteins, sugars, fats, minerals and vitamins, which improves serum albumin and ameliorates bedsores. The total enteral nutritious composition has a zinc/copper weight ratio of 10-25, and a zinc content of 1.5 mg or greater, a copper content of 0.075-0.15 mg, a sodium content of at least 185 mg, a vitamin B1 content of at least 0.30 mg, a vitamin B2 content of at least 0.25 mg and a protein content of at least 4.0 g, per 100 kcal of the composition. Preferably it has a protein content of at least 5.0 g, a vitamin B6 content of at least 0.30 mg, a biotin content of at least 1.0 ?g, a vitamin B12 content of at least 0.20 ?g, a folic acid content of at least 20 ?g, a ?-carotene content of at least 100 ?g and a vitamin C content of at least 10 mg. Medium-chain fatty acid oils preferably constitute 35% by weight of the fats of the fat source, per 100 kcal of the composition. The preferred composition viscosity is 6-18 mPa·s (25° C.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: September 7, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Toshihiro Ohmori, Naoki Hayashi, Kiyoshi Fujita, Hideki Tanaka, Kazunori Saima, Itaru Kon, Miki Tomoe
  • Patent number: 7736622
    Abstract: Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: June 15, 2010
    Assignee: Cedars-Sinai Medical Center
    Inventors: Henry C. Lin, Mark Pimentel
  • Patent number: 7651716
    Abstract: Methods for reducing side-effects of feeding an individual are provided. The methods comprise administering to the individual a composition comprising an amount of bovine milk providing 1.0 to 1.2 grams of protein per 100 available kilocalories and an amount of a bovine whey material providing 1.0 to 1.2 grams of protein per 100 available kilocalories, said bovine whey material having an alpha-lactalbumin content of 28% to 40% and a beta-lactoglobulin content of 8% to 33% of total protein.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: January 26, 2010
    Assignee: Wyeth LLC
    Inventors: Anne Marie M. Davis, Charles F. Kuhlman
  • Patent number: 7618669
    Abstract: The present invention relates to a low-lactose, partially hydrolyzed infant formula. The carbohydrate component of the infant formula comprises between 0% and 60% lactose and the protein component of the infant formula comprises partially hydrolyzed whey protein and casein, the protein component having a particular molecular weight.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: November 17, 2009
    Assignee: Mead Johnson Nutrition Company
    Inventors: Nagendra Rangavajla, Win-Chin Chiang, Khaled A. Khatib, David A. Wynsen, Gabor Puski, Jon Vanderhoof, Robert A. Burns
  • Patent number: 7615207
    Abstract: Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: November 10, 2009
    Assignee: Cedars-Sinai Medical Center
    Inventor: Henry C. Lin
  • Patent number: 7608245
    Abstract: Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: October 27, 2009
    Assignee: Cedars-Sinai Medical Center
    Inventor: Henry C. Lin
  • Patent number: 7572474
    Abstract: The present invention is directed to a novel method for increasing the production of acetate, decreasing the production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut of a formula-fed infant. The method comprises administration of a therapeutically effective amount of PDX to the infant.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: August 11, 2009
    Assignee: Mead Johnson Nutrition Company
    Inventors: Bryon W. Petschow, Robert J. McMahon, Glen R. Gibson, Robert A. Rastall, Renia Gemmell, Maria Saarela, Anna-Marja Aura
  • Patent number: 7413759
    Abstract: Methods for enhancing cognitive ability in infants are shown. The methods comprise feeding infants baby-food compositions containing docosahexaenoic acid (DHA) in an amount of at least about 0.5 mg per gram of the composition. Infants fed a composition containing DHA from an age of about 6 months to about one year exhibit improved problem solving ability compared to infants fed a composition containing DHA in an amount less than about 5 mg per 100 grams total composition over the same period. The source of the DHA can be DHA-enriched coagulated egg yolk solids present in an amount of from about 5% to about 25% (grams/100 grams). Also shown are methods of making the DHA-enriched baby-food compositions, and methods of providing the compositions to a consumer.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: August 19, 2008
    Assignee: Beech-Nut Nutrition Corporation
    Inventors: Eileen E. Birch, Mary Beth Cool, Robert A. Harvey, Dennis R. Hoffman, Terry L. Rocklin, Virginia A. San Fanandre, Gerald E. Shaul, Richard C. Theuer
  • Patent number: 7323206
    Abstract: Materials and methods for preparing and using All-in-One (“AIO”) formulations suitable for administration to infants and neonates for total parenteral nutrition are provided.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: January 29, 2008
    Assignee: B. Braun Medical Inc.
    Inventors: David Driscoll, Bruce Bistrian
  • Patent number: 7323200
    Abstract: Disclosed are calcium fortified, soy-based, infant nutritional formulas, including powder, liquid, or concentrate embodiments comprising per 100 kcal of formula (A) lipid, preferably up to about 8.0 g, (B) carbohydrate, preferably from about 8.0 g to about 16.0 g, (C) phytase-treated soy protein, preferably up to about 3.5 g and (D) calcium, preferably up to about 90 mg of calcium; wherein the nutritional formula is an infant formula having a calcium to lipid weight ratio of from about 0.002 to about 0.020, and wherein the formula contains not more than about 8.4 mg phytic acid per 100 kcal of formula. It has been found that these calcium-fortified, phytase-treated, soy-based, nutritional formulas provide for softer stools in infant populations, especially as compared to infants fed with other soy-based formulas including commercial soy formulas as well as soy based formulas derived from dephytinization methods other than phytase treatment, e.g., ion exchange.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: January 29, 2008
    Assignee: Abbott Laboratories
    Inventors: James N. Chmura, Kent L. Cipollo, Louis I. Ndife, Karin M. Ostrom
  • Patent number: 7273632
    Abstract: Disclosed is the use of the protein S100B as an infant milk formula supplement.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: September 25, 2007
    Assignees: Istituto Giannina Gaslini
    Inventors: Diego Gazzolo, Fabrizio Michetti
  • Patent number: 7244412
    Abstract: Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: July 17, 2007
    Assignee: Cedars-Sinai Medical Center
    Inventor: Henry C. Lin
  • Patent number: 7223434
    Abstract: Processed baby foods are disclosed which are formulated with oils and/or nucleotides. Oils are added to yield an acceptable ratio of the essential fatty acids, linoleic acid (LA) and ?-linolenic acid (ALA). A blend of 3–6 nucleotides may be added to yield a level of 3–6 mg/100 Kcal, which are associated with a number of biological processes, the most common being the potential to optimize the health of the immune and gastrointestinal systems of breast-fed infants and some infants and young children fed commercial infant formula with added nucleotides.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: May 29, 2007
    Assignee: Gerber Products Company
    Inventors: Julie Cary, Frances Alexandria Coletta, Douglas Neal Hocking, Charles Mohs
  • Patent number: 7223736
    Abstract: The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of ?-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: May 29, 2007
    Assignee: Abbott Laboratories
    Inventors: Bonnie Chandler Abbruzzese, Mark Anthony McCamish, Frederick Oliver Cope, Stephen Joseph DeMichele
  • Patent number: 7172778
    Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: February 6, 2007
    Assignee: South Alabama Medical Science Foundation
    Inventors: Steven W. Bailey, June E. Ayling
  • Patent number: 7141266
    Abstract: Baby-food compositions that enhance visual acuity upon feeding to an infant are shown. The compositions contain docosahexaenoic acid (DHA) in an amount of at least about 0.5 mg per gram of the composition. The source of the DHA can be from DHA-enriched coagulated egg yolk solids present in an amount of from about 5% to about 25% (grams/100 grams). The compositions have an organoleptically acceptable smooth texture as a result of contain an acidulant or as a result of being processed by a microcutter. Also shown are methods for enhancing visual acuity in infants and methods of providing the compositions to a consumer.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: November 28, 2006
    Assignee: Beech-Nut Nutrition Corporation
    Inventors: Richard C Theuer, Eileen E Birch, Dennis R Hoffman, Gerald E Shaul, Terry L Rocklin, Mary B Cool, Virginia A San Fanandre, Robert A Harvey
  • Patent number: 7090879
    Abstract: Disclosed are nutritional formulas, including reconstitutable powders, comprising carbohydrate, protein and a lipid component containing a polyunsaturated fatty acid; and from about 0.25 to about 10 ppm, by weight of the total oil content of the infant formula, of a combination of lutein, lycopene, and beta-carotene with preferred weight ratios of the lutein to beta-carotene of from about 0.0196:1 to about 59:1, the lycopene to beta-carotene of from about 0.00805:1 to about 114:1, and the lutein to lycopene of from about 0.0117:1 to about 108:1. Also disclosed are methods of providing nutrition using the disclosed formulas. The nutritional formulas provide improved product stability and color characteristics.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: August 15, 2006
    Assignee: Abbott Laboratories
    Inventors: Daniel S. Albrecht, Nancy Auestad, Jeffrey M. Boff, Amy Mackey
  • Patent number: 7091244
    Abstract: A process for production of unsaturated fatty acid-containing oils which is characterized by culturing a microorganism belonging to the genus Mortierella subgenus Mortierella in a medium containing a nitrogen source derived from soybean, and collecting the unsaturated fatty acid-containing oil from the cultured product. The oils are obtained with a low 24,25-methylenecholest-5-en-3?-ol content.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: August 15, 2006
    Assignee: Suntory Limited
    Inventors: Kenichi Higashiyama, Kengo Akimoto, Sakayu Shimizu
  • Patent number: 7081239
    Abstract: Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: July 25, 2006
    Assignee: Cedars-Sinai Medical Center Burns and Allen Research Center
    Inventor: Henry C. Lin
  • Patent number: 7070825
    Abstract: The present invention is directed to a new unit dose packaging for infant formula. The infant formula is manufactured as a tablet. One tablet will typically contain sufficient nutrients to produce a single serving of the formula (i.e. the amount of formula an average infant consumes in a single feeding). Other aspects of the invention are directed to feeding an infant such a reconstituted tablet and packaging containing such infant formula tablets.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: July 4, 2006
    Assignee: Abbott Laboratories
    Inventors: Louis I. Ndife, Booker T. Lucas, III, Stephene L. Hohman
  • Patent number: 7048906
    Abstract: Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: May 23, 2006
    Assignee: Cedars-Sinai Medical Center
    Inventors: Henry C. Lin, Mark Pimentel
  • Patent number: 6913778
    Abstract: An infant formula composition is provided comprising a whey fraction wherein 40% or less of the total protein in said fraction is alpha-lactalbumin and more than 8% of the total protein in said whey fraction is beta-lactoglobulin, with the proviso that the percentage of alpha-lactalbumin in said whey fraction is greater than the percentage of beta-lactoglobulin in said whey fraction.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth
    Inventors: Charles F. Kuhlman, Eric Lien, John Weaber, Daniel O'Callaghan
  • Patent number: 6863918
    Abstract: An improved infant formula resulting in reduced constipation, abdominal discomfort and gastrointestinal problems, comprises at least one protein component having a phosphorus content of less than 0.75 g P/100 g protein, and at least one lipid component that can be easily digested by an infant. Preferably, it further comprises at least one prebiotic component, and at least one viscosity-improving component. The protein fraction of the formula is preferably a hydrolysate prepared by hydrolysing a protein starting material, especially a whey protein with a combination of at least one endo- and at least one exoproteinase.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: March 8, 2005
    Assignee: N.V. Nutricia
    Inventors: Jacob Geert Bindels, Antonie Van Baalen, Robert Johan Joseph Hageman, Peti Huybers, Liliane Marie-Rose Louisa Dominique Dumon
  • Patent number: 6811798
    Abstract: This invention relates to a soy protein product with a modified sugar profile. The soy protein product has desirable flavor and functional properties. The soy protein product has a high sucrose and monosaccharide content and is low in indigestible oligosaccharides. The soy protein product does not have galactinol that is present in soybeans developed to have a low indigestible oligosaccharide content. The soy protein product is rich in isoflavones. The method for manufacturing the soy protein product uses conventional soybeans that have better agronomic properties than soybeans developed to have a low indigestible oligosaccharide content. The method for manufacturing the soy protein product uses a &agr;-galactosidase enzyme. The method for manufacturing the soy protein product retains the natural level of isoflavones occurring in soybeans.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: November 2, 2004
    Assignee: Solae, LLC
    Inventor: Charles W. Monagle
  • Patent number: 6808725
    Abstract: Disclosed is a composition which includes one or more natural isomers of reduced folate selected from the group consisting of (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and polyglutamyl derivatives thereof; and an essential nutrient preparation which includes folic acid and a vitamin other than ascorbic acid.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: October 26, 2004
    Assignee: South Alabama Medical Science Foundation
    Inventors: Steven W. Bailey, June E. Ayling
  • Patent number: 6808736
    Abstract: Infant formulas and methods of providing nutrition to an infant are provided. The formula includes soy hydrolysate and other nutrients.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: October 26, 2004
    Assignee: Nestec S.A.
    Inventors: Nagendra Rangavajhyala, Constance L. Whippie, Chandrasekhara R. Mallangi, Steven Kwon
  • Patent number: 6797309
    Abstract: This invention relates to a soy protein product with a modified sugar profile. The soy protein product has desirable flavor and functional properties. The soy protein product has a high sucrose and monosaccharide content and is low in indigestible oligosaccharides. The soy protein product does not have galactinol that is present in soybeans developed to have a low indigestible oligosaccharide content. The soy protein product is rich in isoflavones. The method for manufacturing the soy protein product uses conventional soybeans that have better agronomic properties than soybeans developed to have a low indigestible oligosaccharide content. The method for manufacturing the soy protein product uses a &agr;-galactosidase enzyme. The method for manufacturing the soy protein product retains the natural level of isoflavones occurring in soybeans.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: September 28, 2004
    Assignee: Solae, LLC
    Inventor: Charles W. Monagle
  • Patent number: 6777391
    Abstract: A composition for an infant formula which comprises a low threonine content; a method of producing the composition; use of the composition in the manufacture of a medicament or nutritional product for addressing the nutritional needs and providing healthy growth of an infant; and a method of addressing the nutritional needs and providing healthy growth of an infant which comprises administering an effective amount of the composition. A preferred embodiment of the composition comprises all of: i) acid whey protein or sweet whey protein from which caseino-glyco-macropeptide has been removed; and ii) free arginine; and iii) free histidine; and iv) free tyrosine or free tryptophan or tryptophan rich milk protein or a mixture thereof.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: August 17, 2004
    Assignee: Nestec S.A.
    Inventors: Zdenek Kratky, Jean-Claude Maire, Olivier Ballevre, Ferdinand Haschke, Rolf Jost, Martinas Kuslys, Niklaus Meister, Marie-Christine Secretin
  • Patent number: 6730337
    Abstract: An isotonic drink that is especially designed for children between the ages of 6 and 12 years. The drink contains water, carbohydrates including fruit juice, a calcium source and vitamin C. The drink has an osmolality of about 300 to about 380 mOsm/kg and a pH of between about 3 and about 4.5. The drink improves hydration compliance when consumed by children.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: May 4, 2004
    Assignee: Nestec S.A.
    Inventors: Libby Hutt, John Verstrate