Pediatric Patents (Class 426/801)
  • Patent number: 6676985
    Abstract: A protein purified from bovine colostral whey and isolated nucleotide sequences encoding the protein is identified. The isolated bovine protein is termed Bovine Lactation Associated Immunotropic (Bo-LAIT) protein. The human homologue of Bo-LAIT protein, Hu-LAIT protein, is also described. A method of activating B cells, and particularly of activating B cells in a mammal, such as a human, in need of such activation by administering LAIT protein is described. LAIT protein can be incorporated into infant formula. LAIT protein can be administered to an infant, as by feeding to the infant such formula. LAIT protein can be incorporated as part of a vaccination, LAIT protein can be administered to a patient having a T cell immune deficiency, for example, a particular T cell dysfunction in which gp39 (CD40L) is under expressed on or totally absent from the cell surface of patient T cells. Preparation of medicaments including LAIT protein for activating B cells in a mammal in need of such activation is described.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: January 13, 2004
    Assignee: The Arthritis & Autoimmunity Research Centre Foundation
    Inventors: Michael H. Julius, Dominik Filipp, Kamel Alizadeh-Khiavi
  • Patent number: 6673381
    Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid. 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: January 6, 2004
    Assignee: South Alabama Medical Science Foundation
    Inventors: Steven W. Bailey, June E. Ayling
  • Patent number: 6656903
    Abstract: A thymus growth stimulating baby food is provided, substantially composed of a fat component, as well as a carbohydrate component and a protein component of animal or vegetable or animal and vegetable but not human origin, whereby the protein component is composed of intact proteins, hydrolyzed proteins, peptides or the constituents thereof, or of amino acids or a mixture thereof not bound to peptides or proteins. This type of baby food is characterized in that the total amount of arginine is at least 3.7 g per 100 g of the amino acids present in toto, and that it contains zinc (calculated as elementary zinc) in an amount of at least 40 mg per 100 g of the amino acids present in toto.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: December 2, 2003
    Assignee: N. V. Nutricia
    Inventors: Gunther Sawatzki, Gunther Bohm, Gilda Georgi
  • Patent number: 6645543
    Abstract: A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy to protein in “soy milk”, as well as digestive or absorption problems resulting in a damaged gut. Because such an infant must derive all its protein from amino acids it is not fed any ingredient derived from mammalian milk, but a combination of amino acids with nucleotides in specified amounts along with free L-glutamine, maintaining specified ratios of their relative amounts, which ratios in the ranges stated are found to be beneficial for healing of the infant's damaged gut, and for promoting cell division to assure its normal growth. A typical feeding of 32.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: November 11, 2003
    Assignee: Novartis Nutrition AG
    Inventors: Sharon Gohman, Carol Jo Lowry
  • Patent number: 6627213
    Abstract: Disclosed herein are infant supplements containing casein, a salt of casein, whey and/or a casein hydrolysate which are free of carbohydrate, and methods for their use with breast feeding babies. The supplements are designed to suppress serum bilirubin levels and the incidence and severity of neonate jaundice. In one form, a dose of such a supplement is mixed with human breast milk and fed to the neonate.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: September 30, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Glenn R. Gourley, Bill L. Kreamer
  • Patent number: 6613367
    Abstract: The invention relates to products for complete nutrition of infants. The products are characterized by the type and amount of protein and carbohydrate and the increased levels of folic acid, vitamin B6 and vitamin B12 or their functional equivalents. These products improve feelings of well-being of infants, especially those of young age, and are useful in the treatment and prevention of diseases that are associated with disorders of serotonin- and melatonin metabolism.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: September 2, 2003
    Assignee: N.V. Nutricia
    Inventors: John Cowper Kingston Wells, Robert Johan Joseph Hageman, Günther Boehm, Gilda Georgi, Günther Sawatzki, Jacob Geert Bindels
  • Patent number: 6605310
    Abstract: The present invention provides a liquid oral supplement and a method for using the same. The supplement provides at least 2.25 calories per ml and provides at least 15% by caloric content of protein.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: August 12, 2003
    Assignee: Nestec S.A.
    Inventors: Eileen Fuchs, Chandrasekhara R. Mallangi, Peter Carhuff
  • Patent number: 6599939
    Abstract: A stabilized lipid composition of randomly interesterified triacylglycerols (TAGs) that includes, by weight of fatty acid components, long-chain polyunsaturated fatty acids (LC-PUFAs) having at least 20 carbon atoms and a degree of unsaturation of at least 4 and being present in a nutritionally beneficial amount but less than 5% by weight; and medium-chain saturated fatty acids (MC-SFAs) having six to fourteen carbon atoms and being present to promote absorption of the LC-PUFAs. The LC-PUFAs are mono-LC-PUFAs. Also, a nutritional product or infant food product that contains the lipid composition as a portion of the lipids therein, and methods to make such compositions and products.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: July 29, 2003
    Assignee: Nestac S.A.
    Inventors: Junkaun Wang, Raymond Bertholet
  • Patent number: 6596767
    Abstract: The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: July 22, 2003
    Assignee: Abbott Laboratories
    Inventors: Marc L. Masor, Debra L. Ponder, John D. Benson, Gary E. Katz
  • Patent number: 6579551
    Abstract: Baby-food compositions containing about 5% to about 25% egg-yolk solids and an acidulant in an acceptable, shelf-stable, baby-food preparation is set forth. The acidulant can be an acid, a cultured food substance containing lactic acid or a fruit or vegetable component which contributes acidity to the composition or a combination thereof. Also described are methods for preparing and using the compositions.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: June 17, 2003
    Assignee: Beech-Nut Nutrition Corporation
    Inventors: Richard C. Theuer, Gerald E. Shaul, Terry L. Rocklin, Mary Beth Cool, Virginia A. San Fanandre
  • Patent number: 6511696
    Abstract: A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy to protein in “soy milk”, as well as digestive or absorption problems resulting in a damaged gut. Because such an infant must derive all its protein from amino acids it is not fed any ingredient derived from mammalian milk, but a combination of amino acids with nucleotides in specified amounts along with free L-glutamine, maintaining specified ratios of their relative amounts, which ratios in the ranges stated are found to be beneficial for healing of the infant's damaged gut, and for promoting cell division to assure its normal growth. A typical feeding of 32.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: January 28, 2003
    Assignee: Novartis Nutrition AG
    Inventors: Sharon Gohman, Carol Jo Lowry
  • Patent number: 6506422
    Abstract: A nutritional formula for PKU patients. The nutritional formula has, as a protein source, a mixture of caseino-glyco-macropeptide and complementary essential amino acids other than Phe to provide a balanced amino acid profile. Vitamins and minerals sufficient to meet daily requirements are also included. When used as a complete diet, the nutritional formula includes a carbohydrate source and a fat source. However the nutrutional formula may also be used as a protein supplement in which case the carbohydrate source and the fat source may be omitted. The nutritional formula has a pleasant taste.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: January 14, 2003
    Assignee: Nestec S.A.
    Inventors: Gérard Masson, Julio Cesar Monti, Olivier Ballevre
  • Publication number: 20020192296
    Abstract: Compositions containing human milk proteins, including the so-called host resistance factors of human milk, prepared by chemically synthesizing the human milk proteins or by genetic engineering techniques for producing recombinant human milk proteins, are useful for supplementing or enhancing the diet of infants, particularly very-low-birth-weight infants. The human milk proteins include the host resistance factors (HRF) found in human milk, such as lactoferrin (LF), lactoperoxidase (LP), lysozyme (LZ), immunoglobulin-A (IgA), alpha-lactalbumin, alpha, beta, kappa-caseins, and others. The compositions may also include components other than the human milk proteins useful for improved infant nutrition. In the utilization of the compositions of this invention, the compositions would be administered to an infant in at least an amount that the infant would receive if fed substantially only fresh human milk.
    Type: Application
    Filed: April 24, 2002
    Publication date: December 19, 2002
    Inventors: Gerald E. Gaull, Florence McSherry Heffernan Gaull
  • Patent number: 6472003
    Abstract: The invention relates to a powdered human milk fortifier comprising a protein component typically present in an amount of from about 24 wt/wt % to about 55 wt/wt % of the fortifier powder, and a fat component typically present in an amount of from about 1 wt/wt % to about 30 wt/wt % of the fortifier powder and a carbohydrate component present in a quantity of from about 15 wt/wt % to about 75 wt/wt % of the fortifier powder. Preferably, the powdered human milk fortifier is provided in a unit dose container which holds from about 0.5 gm to about 10 gm of powder. The instant invention also relates to a method of providing nutrition to preterm infants by adding a fortifier powder to human milk and administering the fortified human milk to a premature infant. The invention further provides a method of promoting growth of a premature infant by administering fortified human milk to a premature infant.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: October 29, 2002
    Assignee: Abbott Laboratories
    Inventors: Bridget Barrett-Reis, Patricia A. Reynolds, Michael B. Montalto, Deborah L. O'Connor
  • Patent number: 6458395
    Abstract: The present invention provide a gelatinous food product for supplying balanced nutrition, which is a gel of an emulsified mixture comprising 10 to 50 wt. % of total solid content on a dry weight basis and 50 to 90 wt. % of water, the solid content contains 30 to 90 wt. % of saccharide, 5 to 40 wt. % of lipid, 2 to 60 wt. % of protein, 0.2 to 5 wt. % of organic acid, 0.2 to 5 wt. % of organic acid salt, 0.2 to 5 wt. % of emulsifying agent and 0.2 to 5 wt. % of gelling agent, the food product having a pH of 3.3 to 4 and being a composite of an isoelectric gel of the protein and a heat-soluble gel formed with the gelling agent. The invention also provides a process for preparing the food product. The gelatinous food product of the invention is particularly suitable for nutrition of patients with dysphagia, since it comprises various nutrients in suitable proportions and has good eating qualities, for instance, ease of swallowing even by patients with dysphagia, owing to the soft jelly form.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: October 1, 2002
    Assignee: Otsuka Foods Co., Ltd.
    Inventor: Mitsuo Emoto
  • Patent number: 6451360
    Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: September 17, 2002
    Assignee: South Alabama Medical Science Foundation
    Inventors: Steven W. Bailey, June E. Ayling
  • Patent number: 6436464
    Abstract: An emulsifying system for elemental diet compositions is provided that contains a protein source that may be a extensively hydrolyzed protein, free amino acids, short-chain peptides, or a mixture thereof; a lipid source; a carbohydrate source; and an emulsifying system comprising an ocentyl succinic anhydride modified starch and an acetylated monoglyceride emulsifier. The composition may be prepared as a powder or liquid nutritional composition for formulas prepared for infant, pediatric and adult populations in need of an elemental diet. The invention provides a commercially acceptable product in terms of desired stability and physical characteristics and is particularly useful for hypoallergenic infant formula preparations.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: August 20, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventor: John Euber
  • Patent number: 6432457
    Abstract: The invention provides a confectionery bar containing a proteinaceous material and a carbohydrate material in a relative weight ratio higher than 1 (from 1:0 to about 1:0.999). The bar produced is very palatable and chewy and has good organoleptic properties. It may be coated (enrobed) or not as desired. The product of the invention provides a meal replacement for very low calorie diets, diet supplement or protein supplement, and may optionally comprise a carbohydrate material of low digestibility or indigestible nature.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: August 13, 2002
    Assignee: Bariatrix Products International, Inc.
    Inventor: Dennis Jones
  • Publication number: 20020106436
    Abstract: A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy to protein in “soy milk”, as well as digestive or absorption problems resulting in a damaged gut. Because such an infant must derive all its protein from amino acids it is not fed any ingredient derived from mammalian milk, but a combination of amino acids with nucleotides in specified amounts along with free L-glutamine, maintaining specified ratios of their relative amounts, which ratios in the ranges stated are found to be beneficial for healing of the infant's damaged gut, and for promoting cell division to assure its normal growth. A typical feeding of 32.
    Type: Application
    Filed: December 13, 2000
    Publication date: August 8, 2002
    Inventors: Sharon Gohman, Carol Jo Lowry
  • Patent number: 6428832
    Abstract: The present invention relates to a process for the preparation of a polyunsaturated fatty acid (PUFA)-containing food, such as an infant formula, where a composition comprising a PUFA is added at a late stage of the infant formula preparation process in this way, the PUFA's are minimally exposed to conditions during the process that induce degradation of the PUFA's.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: August 6, 2002
    Assignee: DSM N.V.
    Inventors: Anthonius Cornelis Van Den Burg, Jan Willem Groenendaal
  • Publication number: 20020068124
    Abstract: The object of the present invention is to provide a new healthy drink effectively utilizing azuki bean which is rich in mineral components and polyphenol components, and its production method. Washing a desired amount of azuki beans and extracting them under a certain heating condition to obtain an extracted liquid containing minerals and polyphenols from azuki bean, diluting the extracted liquid for adjusting concentration and filling it up in a closed container, heating and cooling the liquid in the closed container, followed by aging, to obtain a healthy drink containing sodium, calcium, magnesium, potassium, iron, tannin originated from azuki bean.
    Type: Application
    Filed: September 27, 2001
    Publication date: June 6, 2002
    Inventor: Kiyoji Endo
  • Patent number: 6387883
    Abstract: The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of &ohgr;-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: May 14, 2002
    Assignee: Abbott Laboratories
    Inventors: Bonnie Chandler Abbruzzese, Mark Anthony McCamish, Frederick Oliver Cope, Stephen Joseph DeMichele
  • Publication number: 20020044989
    Abstract: Compositions containing human milk proteins, including the so-called host resistance factors of human milk, prepared by chemically synthesizing the human milk proteins or by genetic engineering techniques for producing recombinant human milk proteins, are useful for supplementing or enhancing the diet of infants, particularly very-low-birth-weight infants. The human milk proteins include the host resistance factors (HRF) found in human milk, such as lactoferrin (LF), lactoperoxidase (LP), lysozyme (LZ), immunoglobulin-A (IgA), alpha-lactalbumin, alpha, beta, kappa-caseins, and others. The compositions may also include components other than the human milk proteins useful for improved infant nutrition. In the utilization of the compositions of this invention, the compositions would be administered to an infant in at least an amount that the infant would receive if fed substantially only fresh human milk.
    Type: Application
    Filed: May 3, 2001
    Publication date: April 18, 2002
    Inventor: Gerald E. Gaull
  • Patent number: 6372460
    Abstract: This invention provides a particulate material suitable for use as a nutritional supplement, particularly as an aquaculture feed. The particulate material has a high proportion of DHA residues in the lipid fraction, which may be up to 35% of the material, or even more. Preferably, the material has a mean particle size of from about 5 microns to about 10 microns. This invention also provides a method for preparing a particulate material suitable for use as an aquaculture feed from microbial biomass, preferably from algal cells having a high content of DHA residues, by obtaining a lipid fraction from the biomass, preferably by solvent extraction of broken cells, followed by separating a fraction containing phospholipids and proteins from the lipid fraction, and removing water from the protein/phospholipid fraction to form a low moisture particulate, preferably by spray-drying the protein/phospholipid fraction.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: April 16, 2002
    Assignee: Martek Biosciences
    Inventors: Raymond M. Gladue, Paul W. Behrens
  • Patent number: 6368654
    Abstract: A method for making fruit and vegetables purees includes selecting raw produce of the type having meat with a cell structure that is not ruptured by cooking or macerating, and seeds and/or skins. The seeds and/or skins are separated from the meat at substantially ambient temperature by extruding the meat through perforations to form a cold break. The cold break is heated to a temperature which cooks the same into a puree. The puree is then finished to the desired texture and consistency.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: April 9, 2002
    Assignee: Gerber Products Company
    Inventors: Willis DeWayne Evans, Tracy A. Baker, William P. Burnaw, Richard H. Friday, Randall L. McDaniel, Robert A. Owens, Allen Bruce Zerlaut
  • Patent number: 6365218
    Abstract: The present invention provides an improved pediatric formula and methods for providing nutrition to and enhancing tolerance in pediatric patients. The formula may be provided in powder, concentrate or ready-to-feed forms. The pediatric formula comprises, based on a 100 kcal basis, about 8 to about 16 grams carbohydrate (preferably about 9.4 to about 12.3 grams), about 3 to about 6 grams lipid (preferably about 4.7 to about 5.6 grams), about 1.8 to about 3.3 grams protein (preferably about 2.4 to about 3.3 grams), and a tolerance improver comprising about 37 to about 370 milligrams (preferably about 74 to about 222 milligrams, more preferably about 111 to about 148 milligrams) xanthan gum.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: April 2, 2002
    Assignee: Abbott Laboratories
    Inventors: Marlene W. Borschel, Steven T. Luebbers, Cynthia J. Black, Daniel L. McKamy, Timothy Costigan
  • Publication number: 20020031576
    Abstract: The invention relates to a powdered human milk fortifier comprising a protein component typically present in an amount of from about 24 wt/wt % to about 55 wt/wt % of the fortifier powder, and a fat component typically present in an amount of from about 1 wt/wt % to about 30 wt/wt % of the fortifier powder and a carbohydrate component present in a quantity of from about 15 wt/wt % to about 75 wt/wt % of the fortifier powder. Preferably, the powdered human milk fortifier is provided in a unit dose container which holds from about 0.5 gm to about 10 gm of powder. The instant invention also relates to a method of providing nutrition to preterm infants by adding a fortifier powder to human milk and administering the fortified human milk to a premature infant. The invention further provides a method of promoting growth of a premature infant by administering fortified human milk to a premature infant.
    Type: Application
    Filed: July 20, 2001
    Publication date: March 14, 2002
    Inventors: Bridget Barrett-Reis, Patricia A. Reynolds, Michael B. Montalto, Deborah L. O'Connor
  • Patent number: 6355297
    Abstract: The invention relates to the use of a protein component based on conventional proteins used for the production of foods, at least 20 wt-% thereof having a phosphate residue, which is covalently bound to the protein, whereby 50 to 100 wt-% of the proteins including at least one covalently bound phosphate residue, are subjected to a dephosphorylation reaction wherein 20 to 100% of the covalently bound phosphate residues were removed, for a treatment of adult and adolescent patients, as well as of babies and small children suffering from a disturbed gastrointestinal motility and of reflux-predisposed patients. The use of said protein component not only allows for a sufficient protein supply but it also passes rapidly through the stomach and prevents the stomach contents from flowing back into the oesophagus.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: March 12, 2002
    Assignee: N.V. Nutricia
    Inventors: Günther Sawatzki, Gilda Georgi, Günther Böhm
  • Patent number: 6333055
    Abstract: The use of a physiologically innocuous ammonium compound and/or urea as an additive to an infant formula or a pap or for the preparation of a pharmaceutical composition for the prophylaxis of sudden infant death syndrome (SIDS) is disclosed as is also an infant formula or a pap which in addition to conventional ingredients contains a physiologically innocuous ammonium compound and/or urea. Futhermore, a method of preventing SIDS is disclosed, which method comprises administering to the infant an infant formula or a pap as indicated above, and a method for the prophylaxis of SIDS, wherein a pharmaceutical composition containing a physiologically innocuous ammonium compound and/or urea is administered to the infant or the appropriately selected or modified non-pathogenic, urease-producing bacteria are supplied to the gastrointestinal tract of the infant.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: December 25, 2001
    Inventor: Lars Wiklund
  • Publication number: 20010051204
    Abstract: The present invention relates to a process for the preparation of a polyunsaturated fatty acid(PUFA) -containing food, such as an infant formula, where a composition comprising a PUFA is added at a late stage of the infant formula preparation process. In this way, the PUFAs are minimally exposed to conditions during the process that induce degradation of the PUFAs.
    Type: Application
    Filed: March 18, 1997
    Publication date: December 13, 2001
    Inventors: ANTHONIUS CORNELIS, JAN WILLEM GROENENDAAL
  • Patent number: 6326355
    Abstract: The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of &ohgr;-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof, of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: December 4, 2001
    Assignee: Abbott Laboratories
    Inventors: Bonnie Chandler Abbruzzese, Mark Anthony McCamish, Frederick Oliver Cope, Stephen Joseph Demichele
  • Publication number: 20010029267
    Abstract: The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant.
    Type: Application
    Filed: February 20, 2001
    Publication date: October 11, 2001
    Inventors: Matthew A. Kuchan, Marc L. Masor, Debral L. Ponder, Robin J. Halter, John D. Benson, Gary E. Katz
  • Patent number: 6294206
    Abstract: The invention relates to a powdered human milk fortifier comprising a protein component typically present in an amount of from about 24 wt/wt % to about 55 wt/wt % of the fortifier powder, and a fat component typically present in an amount of from about 1 wt/wt % to about 30 wt/wt % of the fortifier powder and a carbohydrate component present in a quantity of from about 15 wt/wt % to about 75 wt/wt % of the fortifier powder. Preferably, the powdered human milk fortifier is provided in a unit dose container which holds from about 0.5 gm to about 10 gm of powder. The instant invention also relates to a method of providing nutrition to preterm infants by adding a fortifier powder to human milk and administering the fortified human milk to a premature infant. The invention further provides a method of promoting growth of a premature infant by administering fortified human milk to a premature infant.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: September 25, 2001
    Assignee: Abbott Laboratories
    Inventors: Bridget Barrett-Reis, Patricia A. Reynolds, Michael B. Montalto, Deborah L. O'Connor
  • Publication number: 20010022986
    Abstract: Dairy permeate, the liquid component of milk or whey which remains after filtration recovery of proteins, is rich in vitamins and minerals. The permeate is collected, immediately processed to arrest the activity of cheese-making bacteria. One or more flavoring agents are added to whey permeate form an electrolyte beverage useful as a sports drink or as a therapeutic to replace electrolyte loss. The beverage is extremely low in milk protein, and may be used by individuals having mild to moderate milk protein allergy. Such individuals comprise the vast majority of the milk-allergic population. Hypoallergenic protein and optional fat is added to milk or whey permeate to form a substantially hypoallergenic milk product.
    Type: Application
    Filed: December 7, 2000
    Publication date: September 20, 2001
    Inventor: Leonard S. Girsh
  • Patent number: 6287623
    Abstract: Provided are a method for producing a protein-containing acidic food and drink that comprises processing a protein emulsion having a pH value that is higher than the isoelectric point of the protein in the emulsion at a high temperature to make the emulsion having a pH value that is lower than the isoelectric point of the protein; the protein-containing acidic food and drink produced in the method; protein-containing acidic food and drink containing protein, fat and oil, and water-soluble polysaccharide, in which the particles dispersed have a mean particle size of not greater than 15 &mgr;m; and a protein-containing acidic drink containing protein, fat and oil, and water-soluble polysaccharide, in which the particles dispersed have a mean particle size of not greater than 15 &mgr;m and/or having a viscosity not greater than 20 centipoises (cPs). The protein-containing acidic food and drink is smooth, tasteful, palatable and has good storage stability.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: September 11, 2001
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Motokazu Nakayama, Ayako Muromachi, Shinpei Harada, Iwao Sato
  • Patent number: 6277426
    Abstract: A process for producing a whey product with extended shelf life, involving defatting the whey byproduct of cheesemaking, pasteurizing the defatted whey the first time, adding an adjuvant to the pasteurized whey, optionally adjusting the pH of the adjuvant-containing whey, pasteurizing the optionally pH-adjusted whey a second time, and recovering of the whey product.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: August 21, 2001
    Assignee: Swiss Alpine Power, Inc.
    Inventor: Hanspeter Reust
  • Patent number: 6274141
    Abstract: A method and apparatus enable the immune system of an infant to distinguish between ABBOS protein sections and p69 protein sections and reduces the risk that an infant will develop diabetes. The method cleaves protein-to-protein bonds in bovine serum albumin to reduce the similarity between the bovine serum albumin and pancreatic beta cells to minimize the likelihood that an infant will develop bovine serum albumin antibodies which will attack and kill the pancreatic beta cells.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: August 14, 2001
    Inventor: Woodrow C. Monte
  • Patent number: 6274179
    Abstract: Disclosed are food compositions containing proanthocyanidin-free barley and a nutritionally effective amount of an iron compound in an organoleptically acceptable composition. The proanthocyanidin-free barley food composition does not develop the gray color seen with typical commercially available barley flour compositions to which an iron compound has been added. Also disclosed are methods of making the food composition and methods for restoring nutritional iron balance by feeding the food compositions to an individual having iron deficiency.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: August 14, 2001
    Inventor: Richard C. Theuer
  • Patent number: 6270827
    Abstract: Compositions containing human milk proteins, including the so-called host resistance factors of human milk, prepared by chemically synthesizing the human milk proteins or by genetic engineering techniques for producing recombinant human milk proteins, are useful for supplementing or enhancing the diet of infants, particularly very-low-birth-weight infants. The human milk proteins include the host resistance factors (HRF) found in human milk, such as lactoferrin (LF), lactoperoxidase (LP), lysozyme (LZ), immunoglobulin-A (IgA), alpha-lactalbumin, alpha, beta, kappa-caseins, and others. The compositions may also include components other than the human milk proteins useful for improved infant nutrition. In the utilization of the compositions of this invention, the compositions would be administered to an infant in at least an amount that the infant would receive if fed substantially only fresh human milk.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: August 7, 2001
    Inventors: Gerald E. Gaull, by Florence McSherry Gaull
  • Publication number: 20010009684
    Abstract: Disclosed are vegetable compositions having an improved green color comprising a processed green vegetable and at least one zinc salt of a fatty acid, wherein the salt has a low water solubility. The vegetable composition can also contain an enhancing agent which further improves the green color of the composition. Also disclosed are methods for preparing the vegetable composition and a food additive comprising the zinc salt of a fatty acid for use in preparing the vegetable composition. A vegetable composition having improved green color comprising a processed green vegetable and a water-soluble zinc salt with an enhancing agent is also disclosed.
    Type: Application
    Filed: February 7, 2001
    Publication date: July 26, 2001
    Inventor: Richard C. Theuer
  • Patent number: 6254904
    Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: July 3, 2001
    Assignee: South Alabama Medical Science Foundation
    Inventor: Steven W. Bailey
  • Patent number: 6248784
    Abstract: The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closley resembling the breast-fed infant.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: June 19, 2001
    Assignee: Abbott Laboratories
    Inventors: Matthew A. Kuchan, Marc L. Masor, Debra L. Ponder, Robin J. Halter, John D. Benson, Gary E. Katz
  • Patent number: 6200624
    Abstract: This invention is directed to the use of triglycerides containing fatty ester moieties that include arachidonic acid (AA) and docosahexaenoic acid (DHA) in enteral nutritionals or nutritional supplements. These triglycerides are derived from lipid mixtures which have high levels of sterols and phosphorous. A preferred embodiment of the invention comprises an infant or enteral nutritional, or nutritional supplement, that comprises a lipid source derived from egg yolk. The lipid source derived from egg yolk is prepared by transesterification or hydrolysis, subjecting the mixture to distillation, and esterification with glycerin to result in a triglyceride containing the desired fatty acids of AA and DHA and little or no sterols and phosphorus.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: March 13, 2001
    Assignee: Abbott Laboratories
    Inventors: Terrence Bruce Mazer, Robert Alan Miller, Charles Allan McCombs, Scott Donald Barnicki, James Cecil Phillips, Charles Edwan Sumner, Jr.
  • Patent number: 6194009
    Abstract: Refrigeration-shelf-stable ready-to-feed and concentrated infant formulas can be prepared through a ultra-pasteurization and/or pasteurization process. The ultra-pasteurized and/or pasteurized infant formulas contain complete balanced quantities of nutrients.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: February 27, 2001
    Assignee: Princeton Nutrition, LLC
    Inventor: A. Reza Kamarel
  • Patent number: 6190724
    Abstract: A protein composition and a baby food (infant formula) containing this are provided. The protein composition is characterised in that it contains at least 15 wt % (based on the total amount of the proteins) modified proteins, the course of whose digestion is slowed compared to the unmodified, normal proteins serving as starting materials. Such a protein composition and a baby food containing this create just as good metabolic conditions for the normal development of a child as feeding with human milk proteins.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: February 20, 2001
    Assignee: N.V. Nutricia
    Inventors: Günther Sawatzki, Günther Böhm, Gilda Georgi, Friedrich Schweikhardt
  • Patent number: 6162472
    Abstract: A milk based formula for premature infants has been discovered. The formula has a reduced lactose content, preferably less than 20%. Premature and low birth-weight infants fed the infant formula demonstrate improved feeding tolerance.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: December 19, 2000
    Assignee: University of Virginia Patent Foundation
    Inventors: M. Pamela Griffin, James W. Hansen
  • Patent number: 6156368
    Abstract: A lactose-containing food compositions for infants for improving the stool color of infants closer to that of breast-fed infants, which contains the lactose-containing foods for infants of which the only protein source is substantially cow's milk protein and/or a processed product of cow's milk protein modified to be administered to infants, and raffinose added into the foods for infants at a ratio of at least 0.05% (by weight) in a ready-to-use state. This food composition provides foods for infants more suitable for infant growth (infant formula, protein hydrolyzed formula, formula for low-birth-weight infants, follow-up formula, etc.) without causing a green stool which is observed when administering a conventional food for sucking infants, of which the only protein source is substantially cow's milk protein and/or a processed product of cow's milk protein.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: December 5, 2000
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Hirotoshi Hayasawa, Kouichi Takahashi, Kazuyoshi Nanba, Takashi Simizu, Kouji Sayama, Yosuke Shimizu, Tsutom Aritsuka, Taizo Nagura
  • Patent number: 6149964
    Abstract: A baby food composition is provided which comprises 5% to 25% egg yolk solids. The composition can be made with egg yolks enriched in docosahexaenoic acid (DHA) to provide the daily recommended amount of DHA for infants in only one or two servings. Also provided are methods for using and making the baby foods.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: November 21, 2000
    Assignee: Beech-Nut Nutrition Corporation
    Inventors: Richard C. Theuer, Gerald E. Shaul, Terry L. Rocklin, Mary Beth Cool, Virginia A. SanFanandre-Russo
  • Patent number: 6146670
    Abstract: A nutritional formulation containing at least one of the following oligosaccharides: from about 400 to about 3500 mg/L of 3-fucosyllactose; from about 200 to about 2200 mg/L of lacto-N-fucopentaose III; from about 100 to about 1500 mg/L of lacto-N-fucopentaose II; from about 100 to about 2500 mg/L of difucosyllactose; from about 500 to about 4500 mg/L of 2' fucosyllactose; from about 250 to about 3300 mg/L of lacto-N-fucopentaose I; from about 100 to about 900 mg/L of Lacto-N-neoTetraose; from about 50 to about 2300 mg/L of lacto-N-fucopentaose V; or from about 300 to about 2800 mg/L of lacto-N-tetraose.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: November 14, 2000
    Assignee: Abbott Laboratories
    Inventors: Pedro A. Prieto, Stephen J. Kirchner, Renee M. Erney
  • Patent number: 6136858
    Abstract: The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: October 24, 2000
    Assignee: Abbott Laboratories
    Inventors: Matthew A. Kuchan, Marc L. Masor, Debra L. Ponder, Robin J. Halter, John D. Benson, Gary E. Katz