For Contacting Living Body Or Transfusing Bodily Fluid (e.g., Endoscope, Electrode, Thermometer, Probe) Patents (Class 427/2.12)
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Patent number: 8003157Abstract: A system for coating a stent includes a device for weighing a stent, a device for aligning the stent with a stent support, a device for coating the stent, a device for drying the stent, and a device for inspecting the stent.Type: GrantFiled: June 15, 2007Date of Patent: August 23, 2011Assignees: Abbott Cardiovascular Systems Inc., ATS Automation Tooling Systems Inc.Inventors: Anthony S. Andreacchi, Yung-Ming Chen, Arnoldo M. Currlin, Antonio Garcia, Jason Van Sciver, Bryan D. Glenn
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Patent number: 8003158Abstract: Various embodiments of methods for coating stents are described herein. One method is directed to a stent spraying apparatus calibration procedure. Another method is directed to obtaining a batch of stents where each stent has the same number of layers of coatings, and the same total amount of coating material.Type: GrantFiled: September 28, 2007Date of Patent: August 23, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Kevin Jow, Daniel A. Castro
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Patent number: 7998666Abstract: An analyte test element for determining the concentration of at least one analyte in a physiological sample fluid having a first and a second surface in a predetermined distance opposite from each other, said both surfaces are provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas with high surface energy create a sample distribution system with at least two detection areas, characterized in that the detection areas of first and second surface are also provided with two corresponding patterns of working and reference electrodes of electrochemical detection means.Type: GrantFiled: August 13, 2004Date of Patent: August 16, 2011Assignee: Egomedical Technologies AGInventors: Matthias Stiene, Ingrid Rohm
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Publication number: 20110189493Abstract: The present invention relates to the use of a crosslinked, silicon-containing layer containing, substantially consisting of or consisting of silicon, O, C, H, optionally N which can be produced by plasma polymerization and/or crosslinking of organosilicon liquids by a plasma process and/or UV radiation of a wavelength of less than 250 nm, without using metals of an atomic number of more than 14, as a biocompatible surface, for imparting to a surface or providing a surface with a non-genotoxic effect. The invention also relates to correspondingly coated articles and to processes for the production thereof.Type: ApplicationFiled: July 31, 2009Publication date: August 4, 2011Inventors: Matthias Ott, Ingo Grunwald, Dirk Salz, Michael Wagener, Klaus-Dieter Vissing, Wolfgang Hielscher, Christopher Dölle
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Publication number: 20110158915Abstract: A particle and a method of manufacturing a particle that includes a complex, a paramagnetic entity, and a silica layer that encapsulates the paramagnetic entity and the complex. The dielectric layer of the particle encapsulates the complex and the paramagnetic entity such that at least a portion of an outer surface of the complex is covered by the paramagnetic entity. In addition, the particle may or may not include a fluorescent entity encapsulated within the dielectric layer. Also, the particle may or may not include a targeting entity covalently bonded to the silica layer.Type: ApplicationFiled: October 29, 2010Publication date: June 30, 2011Applicants: WILLIAM MARSH RICE UNIVERSITY, BAYLOR COLLEGE OF MEDICINEInventors: Rizia Bardhan, Amit Joshi, Nancy J. Halas
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Publication number: 20110152654Abstract: Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.Type: ApplicationFiled: December 21, 2009Publication date: June 23, 2011Applicant: MEDTRONIC MINIMED, INC.Inventors: Jenn-Hann Larry Wang, Tri T. Dang, Brooks B. Cochran, John J. Mastrototaro, Rajiv Shah
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Patent number: 7955636Abstract: Described herein are coatings containing water-soluble oligodynamic metal salts that are formulated and applied from hydrophobic solvents. In particular, articles of manufacture comprising polymer coatings containing oligodynamic metal salts can include hydrophobic polymer coatings made from water-reactive monomers and hydrophilic polymers compounded in hydrophobic solvents which contain a small amount of water that aids in the solubilization and suspension of the oligodynamic metal salts. Methods of preparing these antimicrobial polymer coatings, and methods of coating a substrate to produce an article of manufacture having an antimicrobial polymer coating are also described.Type: GrantFiled: March 2, 2007Date of Patent: June 7, 2011Assignee: C.R. Bard, Inc.Inventor: Richard Terry
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Publication number: 20110123703Abstract: A system and method are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. Selective data input from analysis tools and the end user is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolate, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user.Type: ApplicationFiled: May 18, 2010Publication date: May 26, 2011Inventors: FATEMEH MOHAMMADI, TSUNG-WEI ROBERT MOU, LISA QU
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Publication number: 20110105896Abstract: A multimodal fiducial marker (10) for registration of data is disclosed. The multimodal fiducial marker (10) generally comprises a first portion (12) made from at least one radiopaque material and a second portion (14) made from a porous material capable of absorbing at least one radioactive material. The second portion (14) at least partially surrounds the first portion (12).Type: ApplicationFiled: May 29, 2009Publication date: May 5, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Lyubomir Zagorchev, Douglas Stanton
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Publication number: 20110091817Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.Type: ApplicationFiled: December 28, 2010Publication date: April 21, 2011Applicant: MEDTRONIC MINIMED, INC.Inventors: Rajiv Shah, Rebecca K. Gottlieb
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Publication number: 20110091816Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.Type: ApplicationFiled: December 28, 2010Publication date: April 21, 2011Applicant: MEDTRONIC MINIMED, INC.Inventors: Rajiv Shah, Rebecca K. Gottlieb
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Publication number: 20110086363Abstract: Adhesion of platelets to blood vessel walls is the first step that promotes arrest of bleeding by interaction of the platelet receptors with various extracellular matrix proteins that become exposed on vascular injury. A flow chamber is provided for use in analyzing or studying platelet function, in whole blood, either as part of a batch process or in real time. In the flow chambers, an inert polydimethylsiloxane (PDMS) surface is plasma-activated and a homobifunctional cross-linker is used to immobilize platelet-binding proteins onto a chamber wall surface. Immobilized collagen and fibrinogen may thus be assayed by continuously monitoring the adhesion of ADP and Ca2+ activated platelets from a subject, such as a patient having normal or type 2 diabetes (T2D). The flow chamber provides a simplified and robust method for the construction flow chambers which enable the kinetic monitoring of platelet adhesion in whole blood.Type: ApplicationFiled: October 5, 2010Publication date: April 14, 2011Inventors: Bulent Mutus, Edward C.J. Carriveau, Harmanpreet Kaur
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Publication number: 20110086161Abstract: A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to the substrate member with a photo-reactive crosslinking agent activated in a masking process. The receptive material is specific for an analyte of interest.Type: ApplicationFiled: August 10, 2010Publication date: April 14, 2011Applicant: KIMBERLY-CLARK WORLDWIDE, INC.Inventors: David Cohen, Rosann Kaylor
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Patent number: 7923053Abstract: Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.Type: GrantFiled: April 30, 2007Date of Patent: April 12, 2011Inventors: Kathryn J. Kitching, Catherine E. Taylor
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Publication number: 20110082356Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: October 1, 2009Publication date: April 7, 2011Applicant: Medtronic MiniMed, Inc.Inventors: Qingling Yang, Rajiv Shah, Megan E. Little, Chia-Hung Chiu
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Patent number: 7919138Abstract: Methods of attaching a ligand to a surface are described that include contacting a surface with a substrate containing an amphiphilic comb polymer. The substrate is configured to provide a pattern of the amphiphilic comb polymer on a selected region of the surface. The substrate can be separated from the surface leaving the amphiphilic comb polymer on the selected region of the surface, thus providing a selected region of the surface having amphiphilic comb polymer on it. A ligand can then be deposited on the surface such that the selected region of the surface having the amphiphilic comb polymer is substantially free of the ligand.Type: GrantFiled: October 19, 2006Date of Patent: April 5, 2011Assignee: Duke UniversityInventors: Ashutosh Chilkoti, Zhongping Yang, Jinho Hyun
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Publication number: 20110077477Abstract: Embodiments of the present invention relate to analyte sensors comprising a heparin benzalkonium antithrombogenic coating, and methods of coating analyte sensors.Type: ApplicationFiled: September 30, 2010Publication date: March 31, 2011Applicant: Glumetrics, Inc.Inventors: Matthew A. Romey, Soya Gamsey, David R. Markle
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Patent number: 7910356Abstract: A planar array having plurality of biological recognition molecules including at least two types of biological recognition molecules distributed about a substrate is disclosed. A first type of biological recognition molecules is distributed according to a first frequency and a second type of biological recognition molecules is distributed according to a second frequency. Another planar array having a plurality of biological recognition molecules including at least two kinds of biological recognition molecules is disclosed. The recognition molecules are distributed about a substrate with first kind of biological recognition molecules distributed at a first height or depth relative to a surface of the substrate and a second kind of biological recognition molecules distributed at a second height or depth relative to the surface.Type: GrantFiled: February 1, 2006Date of Patent: March 22, 2011Assignee: Purdue Research FoundationInventors: David D. Nolte, Manoj Varma, Fred E. Regnier, Leilei Peng
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Patent number: 7901875Abstract: This invention provides a device for determining the concentration of an analyte like glucose, cholesterol, free fatty acids, triglycerides, proteins, ketones, phenylalanine or enzymes, in a physiological or aqueous fluid like blood, serum, plasma, saliva, urine, interstitial and/or intra-cellular fluid, the device having an integrated calibration and quality control system suitable for dry reagent test strips with a very small sample volume of about 0.5 ?L based on to a new sample distribution system. The production of the inventive analyte test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the strips.Type: GrantFiled: March 4, 2005Date of Patent: March 8, 2011Assignee: Egomedical Swiss AGInventor: Matthias Stiene
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Patent number: 7895725Abstract: An improved process for manufacturing a biopsy needle assembly is provided. The process may comprise the steps of forming an aperture for receiving tissue to be sampled in an exterior surface of an elongated tube for receiving a cutter, wherein the elongated tube comprises a proximal portion and a distal portion; forming a hole in the exterior surface of the elongated tube; and applying a coating of material over the elongated tube to form a lumen for receiving vacuum on the exterior surface of the elongated tube, wherein the hole in the exterior surface of the elongated tube provides communication between an interior of the elongated tube and an interior of the lumen. In one version, the elongated tube may be placed in a mold configured to form the vacuum lumen when material is injected into the mold. A proximal hub may advantageously be formed by overmolding.Type: GrantFiled: May 8, 2009Date of Patent: March 1, 2011Assignee: Devicor Medical Products, Inc.Inventors: Andrew T. Beckman, Noreen Kascak, Lee Reichel, Michael Ludzack
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Patent number: 7892594Abstract: A system and method for using gradient nanotopography to increase mammalian cell attachment and cell confinement on surfaces. A surface platform consisting of a thin film of gold possessing a gradient of topography on the surface and self-assembled monolayers of alkanethiols presenting desired functional groups is formed. A gradient in the chemical properties is induced in the terminal groups of the monolayer because of the continuous increase in the surface area and the anisotropy of gold film structure. The gradient nanotopraphy provides simultaneous control of two key properties, the presentation of the terminal functional groups and a continuous increase in the surface density of functional groups on the surface. This control provides for drug screening assays using adherent cell-based experiments.Type: GrantFiled: November 21, 2006Date of Patent: February 22, 2011Assignee: Syracuse UniversityInventors: Yan Yeung Luk, Karen A. Simon, Erik A. Burton, Prerli Sejwal, YongBin Han
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Publication number: 20110027453Abstract: Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice.Type: ApplicationFiled: July 1, 2010Publication date: February 3, 2011Applicant: DexCom, Inc.Inventors: Robert Boock, Jeff Jackson, Huashi Zhang, Jason Mitchell
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Publication number: 20110003322Abstract: The invention relates to a sensor (1) comprising a sensing layer (2) and a surface layer (3), wherein said surface layer comprises, a first region (4) suitable for adherent growth of cells (6), and a second region (5), adjacent to said second layer, suitable for the attachment of proteins, wherein the first and second region are in contact with the sensing layer.Type: ApplicationFiled: February 29, 2008Publication date: January 6, 2011Inventor: Dries BRAEKEN
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Publication number: 20100330143Abstract: Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein.Type: ApplicationFiled: April 21, 2010Publication date: December 30, 2010Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Glenn D. Prestwich, Aleksander Skardal, Jianxing Zhang
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Publication number: 20100326765Abstract: An anti-infective stethoscope is described that comprises a tube member; a head member operably connected to the tube member; and first and second earpieces operably connected to the tube member, wherein the tube member and head member include an antimicrobial barrier mechanism. The earpieces may also include an antimicrobial barrier mechanism. According to one embodiment, the antimicrobial barrier mechanism may be provided in the form of a cover comprising an antimicrobial substance wherein the cover operably covers the tube member and head member of the stethoscope. In a preferred form, the antimicrobial barrier mechanism is an antimicrobial substance applied to the tube member, head member, and optionally the earpieces.Type: ApplicationFiled: February 9, 2010Publication date: December 30, 2010Inventor: Patrick E. Eddy
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Publication number: 20100285084Abstract: Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.Type: ApplicationFiled: November 13, 2007Publication date: November 11, 2010Inventors: Zhongping Yang, Eunjoo Jin, Laura Christoferson, Rajiv Shah
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Patent number: 7820227Abstract: A method for biolithographical deposition of molecules is provided. According to an embodiment of the method, a reactive layer (e.g., a polysaccharide mass) having a surface region coated with a biologically compatible resist is provided. A portion of the biologically compatible resist is selectively removed to expose an exposed portion of the reactive layer. Molecules, such as biomolecules and/or cellular species, are then conjugated to the exposed portion of the reactive layer. Also provided are materials and devices related to the method.Type: GrantFiled: February 20, 2004Date of Patent: October 26, 2010Assignees: University of Maryland, College Park, University of Maryland, Baltimore CountyInventors: Gregory F. Payne, Gary W. Rubloff, Hyunmin Yi, Rohan Fernandes, Li-Qun Wu, Reza Ghodssi, William E. Bentley
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Patent number: 7811623Abstract: A method of manufacturing a coated medical device, includes applying a first low-friction coating to a surface of the medical device. The first low-friction coating includes a first colored pigment, such as a relatively light colored pigment. After applying the first low-friction coating, a suitable laser and laser energy is selectively applied to different areas of the coated medical device. The laser ablates or removes the first low-friction coating (at the different areas of the medical device) to leave the bare metal substrate of the medical device exposed. After selectively removing one or more portions of the first low-friction coating, a second low-friction coating is applied to the exposed bare metal substrate of the medical device and suitably cured. The second low-friction coating includes a second colored pigment, such as a relatively dark colored pigment, wherein the second colored pigment contrasts the first colored pigment of the first low-friction coating.Type: GrantFiled: March 11, 2009Date of Patent: October 12, 2010Assignee: Innovatech, LLCInventor: Bruce Nesbitt
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Patent number: 7799367Abstract: Medical catheters are often coated, fully or partially. The present invention relates to systems and methods for coating some portion or all of a medical catheter or one or more of its components.Type: GrantFiled: October 13, 2006Date of Patent: September 21, 2010Assignee: Cordis CorporationInventors: Ryan P. Merritt, Dina E. Agrapides, Vicente J. Fuillerat
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Publication number: 20100221408Abstract: An optical glucose sensor chip includes a substrate, a pair of optical elements formed on a surface of the substrate for introducing light into the substrate and for emitting the light from the substrate, and a glucose sensing membrane formed on the surface of the substrate at a position between the optical elements. The sensing membrane includes a color reagent substrate, a first enzyme which oxidizes or reduces glucose, a second enzyme that generates a material which makes the color reagent substrate exhibit color by a reaction with a product obtained by oxidation or reduction of glucose, a nonionic cellulose derivative, and an ionic polymer into which a buffer is incorporated. At least one of the first and second enzymes is coated with the ionic polymer, and the color reagent substrate. The first and second enzymes, the buffer and the ionic polymer are supported by the nonionic cellulose derivative.Type: ApplicationFiled: April 30, 2010Publication date: September 2, 2010Inventors: Ikuo UEMATSU, Masaaki Hirakawa, Kayoko Oomiya
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Patent number: 7761970Abstract: A method of electrosurgical implements consists of a step of formation of an integral module consisting of a plurality of space from each other interconnected implements, arranged in such manner that a multiplicity of operational spaces are defined between facing each other narrow edges of each pair of adjacent implements. In a coating step a coating is directed normally to the broad planar sides of the implements and substantially parallel to the narrow edges of the implements arranged in the operational spaces.Type: GrantFiled: January 23, 2007Date of Patent: July 27, 2010Inventors: Justin W. Marchese, Sr., John L. Scholz
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Patent number: 7722913Abstract: An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane.Type: GrantFiled: March 31, 2005Date of Patent: May 25, 2010Assignee: Alfred E. Mann Foundation for Scientific ResearchInventors: Joseph H. Schulman, Charles L. Byers, Gerald E. Adomian, Michael S. Colvin
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Publication number: 20100119693Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.Type: ApplicationFiled: January 15, 2010Publication date: May 13, 2010Applicant: DexCom, Inc.Inventors: Mark A. Tapsak, Rathbun K. Rhodes, Mark C. Shults, Jason D. McClure
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Patent number: 7713574Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 10, 2005Date of Patent: May 11, 2010Assignee: DexCom, Inc.Inventors: Mark Brister, James R. Petisce, Sean Saint, Kum Ming Woo, Victor Ha, John Nolting, Peter C. Simpson, James Brauker
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Publication number: 20100111859Abstract: A method for visualizing biological material, preferably by MRI, comprising the steps of: (i) bringing a population of coated nanoparticles into contact with said biological material, each of which nanoparticles comprises a) a metal oxide of a transition metal, said metal oxide preferably being paramagnetic and preferably comprising a lanthanide (+III) such as gadolinium (+III), and b) a coating covering the surface of the core particle, and (ii) recording the image; wherein the coating is hydrophilic and comprises a silane layer which is located next to the surface of the core particle and comprises one or more different silane groups which each comprises an organic group R and a silane-siloxane linkage where a) R comprises a hydrophilic organic group R? and a hydrophobic spacer B, b) O is oxygen directly binding to a surface metal ion of the metal oxide, and c) C is carbon and is also part of B.Type: ApplicationFiled: January 10, 2008Publication date: May 6, 2010Inventors: Oskar Axelsson, Kajsa Uvdal
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Publication number: 20100080759Abstract: The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.Type: ApplicationFiled: April 15, 2009Publication date: April 1, 2010Applicant: CHUNG YUAN CHRISTIAN UNIVERSITYInventors: Walter H. Chang, Cheng-An Lin, Chih-Hsien Lee, Chih-Kuang Yeh
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Publication number: 20100072060Abstract: The present disclosure relates to biomedical electrodes incorporating hydrophobic material and methods of formation thereof.Type: ApplicationFiled: September 25, 2008Publication date: March 25, 2010Applicant: Tyco Healthcare Group LPInventor: Warren Copp-Howland
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Publication number: 20100062143Abstract: A radiotherapy method, comprising positioning a predetermined amount of a radionuclide selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220, in proximity to and/or within a tumor of a subject, for a predetermined time period. The predetermined amount and the predetermined time period are selected sufficient for the radionuclide to administering a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor.Type: ApplicationFiled: August 26, 2009Publication date: March 11, 2010Applicant: Ramot At Tel Aviv University Ltd.Inventors: Itzhak Kelson, Lior Arazi
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Patent number: 7645504Abstract: Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.Type: GrantFiled: June 26, 2003Date of Patent: January 12, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Publication number: 20090308531Abstract: A bi-stable sensor is provided that includes a frame upon which electrical and optical components may be disposed and a coating, such as an overmold coating, provided about the frame. A resistance-providing component is provided integral with or external to the coated bi-stable sensor such that the bi-stable sensor has two mechanically stable configurations that may be transitioned between by overcoming the resistance provided by the resistance-providing component and/or the by the coating. In one embodiment, the resistance-providing component comprises an elastic band provided about a hinge of the frame, either within or external to the coating. In one embodiment, the sensor may be placed on a patient's finger, toe, ear, and so forth to obtain pulse oximetry or other physiological measurements.Type: ApplicationFiled: August 21, 2009Publication date: December 17, 2009Applicant: Nellcor Puritan Bennett LLCInventors: William Raridan, George L. Matlock, Joseph Coakley, Darius Eghbal
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Patent number: 7629016Abstract: The invention relates to a photochemical process for the preparation of an activated polymer surface having an active fluoro group using 1-fluoro-2-nitro-4-azidobenzene to form the activated polymer surface and then immobilizing a biomolecule thereon by forming a covalent bond between the activated polymer surface and the biomolecule.Type: GrantFiled: June 10, 2002Date of Patent: December 8, 2009Assignee: Council of Industrial and Scientific ResearchInventor: Pradip Nahar
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Publication number: 20090281558Abstract: According to an aspect of the present invention, implantable medical articles are provided, which comprise a surgical mesh that is at least partially covered with a coating that comprises a radiopaque material such as a metal or a metallic compound. The radiopaque material is present in the coating in an amount such that the coated portions of the mesh are visible using radiographic imaging techniques. Other aspects of the invention pertain to methods of making and using such medical articles.Type: ApplicationFiled: May 7, 2009Publication date: November 12, 2009Applicant: Boston Scientific Scimed, Inc.Inventor: Jianmin Li
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Publication number: 20090269003Abstract: A sensor for sweat or other aqueous discharge onto skin comprises a plastic optical fibre comprising a core and cladding, said core being in intimate contact at a first end with a light emitter and at a second end with a light detector, and said fibre having a sensing zone in which the cladding is replaced by a water-permeable translucent biocompatible polymer containing dispersed therein a biocompatible indicator that varies the intensity of an optical signal at a selected wavelength depending on whether the indicator is wet or dry. Such a sensor permits real time monitoring of sweating or other discharge, and can also enable electronic recording and/or remote monitoring.Type: ApplicationFiled: July 30, 2007Publication date: October 29, 2009Inventors: Patricia Jane Scully, John Vaughan
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Publication number: 20090260755Abstract: An improved process for manufacturing a biopsy needle assembly is provided. The process may comprise the steps of forming an aperture for receiving tissue to be sampled in an exterior surface of an elongated tube for receiving a cutter, wherein the elongated tube comprises a proximal portion and a distal portion; forming a hole in the exterior surface of the elongated tube; and applying a coating of material over the elongated tube to form a lumen for receiving vacuum on the exterior surface of the elongated tube, wherein the hole in the exterior surface of the elongated tube provides communication between an interior of the elongated tube and an interior of the lumen. In one version, the elongated tube may be placed in a mold configured to form the vacuum lumen when material is injected into the mold. A proximal hub may advantageously be formed by overmolding.Type: ApplicationFiled: May 8, 2009Publication date: October 22, 2009Applicant: Ethicon Endo-Surgery, Inc.Inventors: Andrew T. Beckman, Noreen Kascak, Lee Reichel, Michael Ludzack
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Publication number: 20090248113Abstract: An electrode device is disclosed. The electrode device comprises an electrically conductive core of micrometric size coated by at least one electrically isolating layer. The electrically conductive core comprises a substrate coated by at least one metallic layer having a nanometric pattern thereon and being at least partially exposed at a tip of the electrically conductive core.Type: ApplicationFiled: June 6, 2006Publication date: October 1, 2009Applicant: Nano Biosensors Ltd.Inventors: Emad Nimer, Nabil Jadaon, Fauzi Silbaq
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Publication number: 20090221011Abstract: A test element for the determination of coagulation in a plasma or whole blood sample having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces being provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas of high surface energy create a sample distribution system (6) with at least one detection area (6a), wherein the detection area(s) (6a, 6?a) of the first and second surfaces (2a, 4a) is/are provided with at least one coagulation stimulation reagent. The coagulation test element is provided with an integrated quality control system suitable for dry reagent test strip format with a very small sample volume of about 0.5 ?L. The production of the inventive coagulation test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the element.Type: ApplicationFiled: August 31, 2005Publication date: September 3, 2009Inventors: Matthias Stiene, Eurig Wyn Jones, Sladjana Nincic, Elke Horstkotte
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Publication number: 20090220434Abstract: Nanoparticles that facilitate imaging of biological tissue and methods for formulating the nanoparticles are provided. In order to form suitable nanoparticles for imaging, an anionic surfactant may be applied to superparamagnetic nanoparticles to form modified nanoparticles. The modified nanoparticles may be mixed with a polymer in a solvent to form a first mixture, and a non-solvent may be mixed with the first mixture to form a second mixture. An emulsion may be formed from the second mixture and the polymeric nanoparticles may be isolated from the emulsion. In certain embodiments of the invention, an antibody may be attached to the polymeric nanoparticles to facilitate attachment of the nanoparticles to biological tissue.Type: ApplicationFiled: March 2, 2009Publication date: September 3, 2009Applicant: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATIONInventor: Rakesh Sharma
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Publication number: 20090221891Abstract: A sensor for the in vivo detection of glucose comprises: components of an assay for glucose, a readout of which is a detectable optical signal which can be interrogated transcutaneously by external optical means when the sensor is implanted in vivo; and a shell of biodegradable material encapsulating the assay components whilst allowing analyte to contact the assay components, wherein the biodegradable material comprises a co-polymer having hydrophobic and hydrophilic units. A method of preparing such a sensor preferably comprises coacervation, solvent evaporation and/or extraction, spray drying, spray coating, spray chilling, rotary disk atomisation, fluid bed coating, coextrusion and/or pan coating. A method of detecting glucose using such a sensor suitably comprises implantation of the sensor into the skin of a mammal, transdermal detection or measurement of glucose using external optical means and degradation of the biodegradable material.Type: ApplicationFiled: May 17, 2005Publication date: September 3, 2009Inventors: Yihua Yu, Jesper S. Kristensen
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Publication number: 20090216104Abstract: The presently disclosed subject matter describes acid-derivatized perfluoropolyether (PFPE) materials and their use as coatings, sealants, and flexible fillers for devices, apparatuses, and structural parts for a variety of medical applications, and as coatings, sealants, flexible fillers, and structural parts for vessels, structures, and machinery exposed to a marine environment.Type: ApplicationFiled: August 28, 2006Publication date: August 27, 2009Inventors: Joseph M. DeSimone, Michael S. Williams, Lauren Portnow, Colin Wood, Zhilian Zhou, Everett Baucom, Ginger Denison Rothrock
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Publication number: 20090198117Abstract: Embodiments of the invention provide analyte sensors having nanostructured electrodes as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a carbon nanotube electrode and a analyte limiting membrane that modulates the ability of a analyte to contact the carbon nanotube electrode.Type: ApplicationFiled: January 28, 2009Publication date: August 6, 2009Applicant: MEDTRONIC MINIMED, INC.Inventors: Kenneth W. Cooper, Ratnakar Vejella, Gopikrishnan Soundararajan, Rajiv Shah