Medical Or Dental Purpose Product; Parts; Subcombinations; Intermediates (e.g., Balloon Catheter, Splint) Patents (Class 427/2.1)
  • Patent number: 11441040
    Abstract: The present disclosure is drawn to an electronic device housing that can include a heat sensitive coating and a second heat sensitive coating applied to an electronic device housing. The heat sensitive coating or portion thereof can include a thermochromatic colorant having a color-changing activation temperature, and the second heat sensitive coating or portion thereof can include a second thermochromatic colorant having a second color-changing activation temperature. The color-changing activation temperature can be a temperature from 30° C. to about 100° C., and the second color-changing activation temperature can be at least 5° C. greater than the color-changing activation temperature.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 13, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventor: David H Hanes
  • Patent number: 11419332
    Abstract: The invention is directed to a biocidal composition formed by a reaction or combination of electrolyzed water and an amine, and methods for using same to kill or control microorganisms, such as viruses, bacteria, fungi and algae.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 23, 2022
    Inventors: William Dale Storey, Norman L. Arrison
  • Patent number: 11382732
    Abstract: A portable container is provided for handling an implant. The container comprises a sealed compartment enclosing a fluid of a pre-defined composition and at least one implant configured to be installed in a live subject. The container may comprise at least one electrode made of an electrical conductive material, electrically associated with an electric conductor outside the sealed compartment and configured for applying a plasma generating electric field inside the sealed compartment. An apparatus for plasma treatment of an implant and having an activation device is further provided. The activation device comprises a slot configured to receive a portable container, and an electrical circuit configured to be electrically associated with at least one electrode. The electrical circuit is configured to provide to the at least one electrode electric power suitable for applying a plasma generating electric field in the sealed compartment, when the portable container is disposed in the slot.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 12, 2022
    Assignee: NOVA PLASMA LTD.
    Inventors: Amnon Lam, Aviad Harhol, Eliezer Fuchs, Chen Porat
  • Patent number: 11369498
    Abstract: Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: June 28, 2022
    Assignee: MT Acquisition Holdings LLC
    Inventors: James B. McClain, Douglas Taylor, David Enscore
  • Patent number: 11359156
    Abstract: The invention concerns coating composition comprising hydrophobic polymer for use as a photoreactive basecoat for a medical device or implant comprising a polymer made from monomers comprising: (a) 1 to 12 mol % of at least one photoactive monomer that is a hydrogen atom abstracter and (b) 99 to 88 mol % of one or more of acrylamides, methacrylamides, acrylates, methacrylates, and N-vinylpyrrolidone; wherein the polymer has a glass transition temperature (Tg) of less than 40° C.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: June 14, 2022
    Assignee: Biocoat, Inc.
    Inventors: Tyler Richard Long, Casmir S Ilenda
  • Patent number: 11331416
    Abstract: Provided is a method for manufacturing a stent, including: coating a coating material on a stent; and drying the stent at a temperature in the range of from 40° C. to 150° C., and the coating and the drying are simultaneously performed.
    Type: Grant
    Filed: May 27, 2019
    Date of Patent: May 17, 2022
    Assignee: OSSTEM CARDIOTEC CO., LTD.
    Inventors: Chang Hun Kum, Kwang Soo Kim, Bunam Chang, Jae Hwa Cho, Sung Nam Kang, Gyu Hyun Jin, Hye Young Kwon, Ji Seon Hong, Saet Byeol Kim
  • Patent number: 11298521
    Abstract: Apparatus and methods are described including manufacturing an impeller by coupling a material to a helical elongate element, such that the helical elongate element with the material coupled thereto defines a blade of the impeller. A portion of a structure that includes the helical elongate element is dipped into the material while the material is in a liquid state. The material is dried, while the material is being supported by the at least one helical elongate element. During the drying of material, the structure is rotated about its longitudinal axis, such as to facilitate the formation of a film of the material having a substantially uniform thickness within the impeller blade. Other applications are also described.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: April 12, 2022
    Assignee: Magenta Medical Ltd.
    Inventors: Ehud Schwammenthal, Yosi Tuval, Daniel Glozman
  • Patent number: 11298520
    Abstract: Apparatus and methods are described including an impeller that includes an impeller frame that comprises proximal and distal end portions and at least one helical elongate element that winds from the proximal end portion to the distal end portion. A film of material is coupled to the at least one helical elongate element, such that the helical elongate element with the film of material coupled thereto defines a blade of the impeller. The film of material is shaped to define a hollow central lumen therethrough. Other applications are also described.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: April 12, 2022
    Assignee: Magenta Medical Ltd.
    Inventors: Ehud Schwammenthal, Yosi Tuval, Daniel Glozman
  • Patent number: 11285507
    Abstract: This application relates to a dip coating apparatus for coating a medical assist device such as a catheter or guidewire to a uniform thickness. The apparatus includes a casing and a coating booth disposed in the casing and containing a coating fluid. The apparatus also includes an elevating member vertically movable in the casing and configured to hold an upper end of each of medical assist devices so that the medical assist devices can be hung. The apparatus further includes a position adjusting member for adjusting the height of the elevating member, and a controller for controlling operation of the position adjusting member. The coating booth includes a coating unit having the same length as each medical assist device and a hopper-shaped guide unit that guides a bundle of the medical assist devices to be inserted into the coating unit when the guide unit contacts the medical assist devices.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: March 29, 2022
    Assignee: Noanix Corporation
    Inventor: Hyung Joon Choi
  • Patent number: 11285308
    Abstract: The present invention relates to a microstructure including a biocompatible polymer or an adhesive and to a method for manufacturing the same. The present inventors optimized the aspect ratio according to the type of each microstructure, thereby ensuring the optimal tip angle and the diameter range for skin penetration. Especially, the B-type to D-type microstructures of the present invention minimize the penetration resistance due to skin elasticity at the time of skin attachment, thereby increasing the penetration rate of the structures (60% or higher) and the absorption rate of useful ingredients into the skin. In addition, the D-type microstructure of the present invention maximizes the mechanical strength of the structure by applying a triple structure, and thus can easily penetrate the skin. When the plurality of microstructures are arranged in a hexagonal arrangement type, a uniform pressure can be transmitted to the whole microstructures on the skin.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 29, 2022
    Assignee: ENDODERMA CO., LTD.
    Inventors: Jae Soo Kim, Soon Chang Kwon, Sang Jin Park
  • Patent number: 11254901
    Abstract: A system and method for printing cells in a medium. A multi-dimensional printer, stably constructed of low-mass parts, can include a computer numerically controlled system that can enable motors driving delivery systems. The motors can include encoders that can enable achieving arbitrary resolution. The motors can drive ballscrews to enable linear motion of delivery systems, and the delivery systems can enable printing of a biological material in a pre-selected pattern in a petri dish. The petri dish can accommodate a medium such as a gel, and can further accommodate a vision system that can detect actual position and deflection of the delivery system needle. The printer can accommodate multiple delivery systems and therefore multiple needles of various sizes.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: February 22, 2022
    Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Jonathan Parker, John C. Anastasiou, Michael C. Tilley, David Blumberg, Jr.
  • Patent number: 11193209
    Abstract: Embodiments of the invention include a method of initiating an optical fiber. In some embodiments, a distal portion of the optical fiber is coated with an energy absorbing material. In some embodiments, the material includes a metal flakes or powder dispersed in a solution of organic solvents. After the material dries, laser energy is fired through the optical fiber. The laser energy can be absorbed in the material and ignites the organic solvents. This combustion melts the material of the optical fiber, and impregnates the optical fiber with the metal flakes or powder of the material. The resulting optical fiber is thus permanently modified so that the energy applied through the fiber is partially absorbed and converted to heat.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: December 7, 2021
    Assignee: BIOLASE, INC.
    Inventors: Alina Sivriver, Dmitri Boutoussov
  • Patent number: 11103614
    Abstract: A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-skin.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: August 31, 2021
    Assignee: TRIO HEALTHCARE LIMITED
    Inventors: Lloyd Pearce, Stewart Lee
  • Patent number: 11051976
    Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 ?m and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 ?m.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: July 6, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Kuan-Hui Hsu
  • Patent number: 11040103
    Abstract: A nucleic acid film fabrication method, includes: a mixing step in which a nucleic acid is added in powder form to distilled water or deionized water to prepare a mixed solution; a stirring step in which the mixed solution is stirred; a mixed solution application step in which the mixed solution is applied to a mold corresponding in shape to a final product of a nucleic acid film; and a drying step in which the mixed solution applied to the mold is dried to be formed into the nucleic acid film, wherein the mold has a groove formed thereon in a thickness direction thereof, such that the nucleic acid film passing through the drying step has a protrusion protruding from one surface thereof toward human skin to correspond to the groove.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: June 22, 2021
    Assignee: ADMBIOSCIENCE INC.
    Inventors: Jun-ho Jeong, Yun Woo Lee, So Hee Jeon, Junhyuk Choi, Dae-Guen Choi, Ji Hye Lee, Joo Yun Jung
  • Patent number: 11044024
    Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: June 22, 2021
    Assignee: Proteus Digital Health, Inc.
    Inventors: Mark Zdeblick, Timothy Robertson, Aleksandr Pikelny, Hooman Hafezi
  • Patent number: 11029539
    Abstract: Provided are articles such as medical devices which comprise at least one water soluble, crosslinked copolymer. The primary polymer chains of the copolymer are hydrophilic and independently have a degree of polymerization in the range of about 10 to about 10,000. The water soluble, crosslinked copolymers of the present invention are free from terminal substrate associating segments. The copolymers may be incorporated into a formulation from which the article is made or may be contacted with the article post-formation.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: June 8, 2021
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Charles W. Scales, Kevin P. McCabe, Brent Matthew Healy
  • Patent number: 11007363
    Abstract: A method of forming an implantable electrode having electrode contacts on an electrode carrier having a coating includes providing a solution of silicone and dexamethasone dissolved in a solvent, applying the solution to the electrode carrier or to a substrate, and subjecting the solution to a two-step heat treatment process that includes a first heat treatment between about 50 and 90° C. for about 1 to 3 hours and a second heat treatment at an elevated temperature between 90° C. and 140° C. for about 2 hours in order to form the coating.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: May 18, 2021
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Thomas Tritthart
  • Patent number: 10950364
    Abstract: The present invention provides a bio-electrode including an electro-conductive base material and a living body contact layer formed on the electro-conductive base material; wherein the living body contact layer contains a resin layer and particles dispersed in the resin layer, the particles being coated with gold, platinum, silver, or alloy of these metals; a thickness of the resin layer is equal to or thinner than an average particle size of the particles; the resin layer contains a silicon-containing resin and a non-silicon-containing resin; and the silicon-containing resin is localized in the direction of a surface of the resin layer. The bio-electrode of the present invention is superior in electric conductivity and biocompatibility, light in weight, can be manufactured at low cost, and can combine repellency of the resin layer surface and adhesion properties of the resin layer to particles.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: March 16, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Motoaki Iwabuchi
  • Patent number: 10945843
    Abstract: An exemplary valve repair device for repairing a native valve of a patient has a cap, and a paddle. The paddle has an inner paddle portion and an outer paddle portion. The inner paddle portion and the outer paddle portion are formed from a continuous strip of metal fabric. The outer paddle portion is connected to the cap. The cap is moveable away from the inner paddle portion to open the paddle.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: March 16, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Sergio Delgado, Eric Robert Dixon, David M. Taylor
  • Patent number: 10933162
    Abstract: Disclosed are an implantable medical device, a preparation method thereof and an implantable medical device preform for the preparation of the implantable medical device. The implantable medical device comprises a metal basal body (21) and a polymer film layer (22) covering the surface of the metal basal body (21) and preventing endothelium growth and covering, and also comprises a transitional body (23), which is located between the metal basal body (21) and the polymer film layer (22) and covers at least part of the surface of the metal basal body (21), wherein the transitional body (23) is connected to the polymer film layer (22) and the metal basal body (21). By arranging the transitional body (23) to be connected to the polymer film layer (22) and the metal basal body (21), the polymer film layer (22) will not easily fall off when being implanted into a human body.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: March 2, 2021
    Assignee: Lifetech Scientific (Shenzhen) Co. Ltd.
    Inventors: Zuqiang Qi, Xiaole Jia, Zhou Chen
  • Patent number: 10888617
    Abstract: The present invention is generally directed to materials, gels, coatings and films prepared using a biomaterial (e.g., a fatty acid-based material comprising a network of cross-linked fatty acids) and a fixating material, layer or film (e.g., a fixating material comprising Na-CMC). The materials, gels, coatings and films disclosed herein can be used to facilitate the delivery of one or more therapeutic agents to a targeted tissue and a desired rate of release.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: January 12, 2021
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. Faucher, Suzanne Conroy, Theresa K. Albergo, Joseph Bienkiewicz
  • Patent number: 10874768
    Abstract: The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: December 29, 2020
    Assignee: COVIDIEN LP
    Inventors: Terry Morgan, Beth Sersen, Daniel Schulz-Jander, Joseph Traina, Brian Graham, Carol Sullivan, Gerald Hodgkinson
  • Patent number: 10806912
    Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The method includes moving a drive shaft relative to at least one of a hub of the balloon catheter and an interlocking member. The drive shaft is configured to rotate the balloon catheter about an axis of the balloon. The method fixing the drive shaft to the proximal end of the hub or to the opening of the interlocking member by frictional force, and applying a coating solution containing the drug to the outer surface of the balloon from a dispensing tube while gradually moving the dispensing tube in the axial direction and simultaneously rotating the drive shaft to rotate the balloon catheter around the axis of the balloon catheter.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: October 20, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Goto, Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10809181
    Abstract: The present invention relates to a method and an apparatus (5) for determining a coefficient of friction at a test site (11) on a surface (10) of a contact lens (1). The apparatus comprises: a lens holder (2) arranged at least partially in a receptacle (6); a slide (4) comprising a counter surface (40) made of lapped aluminum for contacting the test site (11); a load generator (7) configured to apply a predetermined normal load (Fn) between the counter surface (40) and the test site; a drive (8) configured to generate a sliding movement between the counter surface (40) and the contact lens in direction located in a plane perpendicular to the normal load (Fn); and a force sensor (9) configured to measure a tangential frictional force (Ft) between the test site and the counter surface (40) along the direction of the sliding movement.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: October 20, 2020
    Assignee: Alcon Inc.
    Inventors: Justyna Justynska-Reimann, Markus Grebe, Michael Ruland, André Wicklein
  • Patent number: 10799684
    Abstract: An introducer sheath, which is formed from a tubular member provided with a hollow portion through which an elongated body is freely insertable, and which includes a distal portion and a main body portion, wherein the inner diameter of the distal portion is formed to become gradually smaller toward the distal side, and on the inner surface of the distal portion, there is provided a hydrophobic coating having a friction coefficient lower than the friction coefficient of the tubular member.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: October 13, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Ryo Okamura
  • Patent number: 10774250
    Abstract: A method of adhering a substantially cured or fully cured silicone based material to a substrate surface is provided. The silicone based material is obtained by curing a condensation curable composition. The condensation curable composition comprises: (I) at least one condensation curable silyl terminated polymer having at least one hydrolysable and/or hydroxyl functional group(s) per molecule; (II) a cross-linker selected from the group of silanes having at least two hydrolysable groups per molecule; and/or silyl functional molecules having at least two silyl groups, each silyl group containing at least one hydrolysable group; and (III) a condensation catalyst selected from the group of titanates and zirconates. The method includes applying a reactive interlayer to the substrate surface and applying pressure to sandwich the reactive interlayer between a surface of the silicone based material and the substrate surface, thereby causing chemical bonding of the silicone based material to the substrate.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: September 15, 2020
    Assignee: DOW SILICONES CORPORATION
    Inventors: Gregory Chambard, Tommy Detemmerman, Tatiana Dimitrova, Frederic Gubbels
  • Patent number: 10632232
    Abstract: A degradable iron-based alloy stent comprises an iron-based alloy substrate and a degradable polymer in contact with the surface of the substrate. The weight-average molecular weight of the degradable polymer is in the range of [1, 100]*104, and the polydispersity index of the degradable polymer is in the range of (1.0, 50]. The degradable polymer is selected from a degradable polyamino acid that can generate an acidic amino acid after degradation; or a mixture of the degradable polyamino acid and a degradable polyester, or a copolymer of monomers of the two; or a mixture of the degradable polyamino acid and a degradable polymer that does not generate acidic products after degradation, or a copolymer of the monomers of the two; or a mixture of the degradable polyamino acid, the degradable polyester and the degradable polymer that does not generate acidic products after degradation, or a copolymer of monomers of the three, or a mixture of a copolymer of monomers of any two of the three with the remaining one.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: April 28, 2020
    Assignee: Lifetech Scientific (Shenzhen) Co., Ltd.
    Inventors: Liping Chen, Hongtao Sun, Deyuan Zhang
  • Patent number: 10632736
    Abstract: A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: April 28, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Misael Omar Aviles, Martin James, Stephen Michael Varga, Hui Yang, Arman Ashraf, Eric Daniel Ricciardi
  • Patent number: 10610593
    Abstract: The present invention is generally directed to materials, gels, coatings and films prepared using a biomaterial (e.g., a fatty acid-based material comprising a network of cross-linked fatty acids) and a fixating material, layer or film (e.g., a fixating material comprising Na-CMC). The materials, gels, coatings and films disclosed herein can be used to facilitate the delivery of one or more therapeutic agents to a targeted tissue and a desired rate of release.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: April 7, 2020
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Keith M. Faucher, Suzanne Conroy, Theresa K. Albergo, Joseph Bienkiewicz
  • Patent number: 10604645
    Abstract: A process for the preparation of polyolefins carried out in the presence of an antistatic composition made from or containing: a) a compound of formula R—OH wherein R represents hydrogen or a linear or branched, saturated alkyl group having from 1 to 15 carbon atoms; and b) an oligomeric or polymeric organic compound having one or more terminal hydroxyl groups and a viscosity at 40° C. of at least about 20 mm2/sec (DIN 51562).
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 31, 2020
    Assignee: Basell Poliolefine Italia S.r.l.
    Inventors: Antonio Mazzucco, Gabriele Mei, Tiziana Caputo, Roberto Pantaleoni, Enrico Balestra, Maria Di Diego, Mara Destro, Riccardo Rinaldi
  • Patent number: 10582996
    Abstract: Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed. In some examples, a vascular graft includes a biodegradable scaffold including a biodegradable polyester tubular core, a biodegradable polyester electrospun outer sheath surrounding the biodegradable polyester tubular core and/or a thromboresistant agent, such as heparin, coating the biodegradable scaffold. The disclosed vascular grafts can be used for forming a blood vessel of less than 6 mm, including, but not limited to a coronary or peripheral arterial.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 10, 2020
    Assignee: University of Pittsburgh—Of The Commonwealth System of Higher Education
    Inventor: Yadong Wang
  • Patent number: 10537280
    Abstract: The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: January 21, 2020
    Assignee: ExThera Medical Corporation
    Inventors: Keith McCrea, Robert S. Ward, George Pitarra, Jr.
  • Patent number: 10525140
    Abstract: A filler material of a thermoset resin of a diacid/polyol, such as PGS is provided. The filler useful in forming composites, such as those in which the filler and a resin matrix are of the same material to provide a homogenous polymeric composition. Composites in which at least one of the matrix, the filler or both are PGS are also provided. Methods of forming such filler materials and composites are also disclosed. The composites allow extrusion process to form articles from materials that would not otherwise be capable of being extruded.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: January 7, 2020
    Assignee: THE SECANT GROUP, LLC
    Inventors: Kayla Wroblesky, Carissa Smoot, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Steven Lu
  • Patent number: 10493793
    Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: December 3, 2019
    Assignee: Brown University
    Inventor: Thomas J. Webster
  • Patent number: 10492708
    Abstract: A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: December 3, 2019
    Assignee: Biolinq, Inc.
    Inventor: Joshua Windmiller
  • Patent number: 10492864
    Abstract: An apparatus includes an optical fiber extending from a proximal end to a distal end. The optical fiber may include a cladding layer circumferentially disposed about a core layer and a substantially spherically shaped portion at the distal end. The apparatus may also include a first coating circumferentially disposed on a first length of the cladding layer, and a second coating circumferentially disposed on a second length of the cladding layer. The second length may extend distally from a region proximate the distal end of the first coating.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: December 3, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jeffrey W. Zerfas, Carl Donadio, David W. Robertson, Richard Tumminelli
  • Patent number: 10441686
    Abstract: The present invention relates to a stent having a functional material coated on a cell space (safe coating space) thereof. The stent of the present invention, as a stent having a space for mounting and coating drugs and other materials for expanding the functions of the stent, is highly feasible as an actual product in consideration of the structure, transfer device, and manufacturing process of the stent as a whole, and secures a coating space (safe coating space) of a functional material in a cell of the stent through quantitative and qualitative modelling. Since an additional increase in volume does not occur even when the stent is press-mounted in a transfer device as a result of mounting a radio marker or a drug in the coating space, the stent of the present invention has excellent radio opacity without obstructing the loading and deployment of the stent, and may stably mount a great amount of a functional drug.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: October 15, 2019
    Assignees: UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER, NEXTBIOMEDICAL CO., LTD.
    Inventors: Don Haeng Lee, Jong Chae Park, Dong Gon Kim, Choong Ryeol Choi
  • Patent number: 10416500
    Abstract: A display device includes a lower display panel, an upper display panel facing the lower display panel, a metal oxide layer surrounding outermost surfaces of the upper display panel and the lower display panel, and a barrier layer surrounding the metal oxide layer. The barrier layer includes a self-assembled monolayer.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: September 17, 2019
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventors: Woo Yong Sung, A Ram Lee, Tae Woon Cha, Sang Youn Han
  • Patent number: 10391284
    Abstract: A balloon coating method and a balloon coating apparatus are disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method including fixing a connection portion between the balloon and an inner tube passing through an inside of the balloon, and moving a dispensing tube relative to the balloon in an axial direction of the balloon while rotating the balloon about an axis of the balloon and while also dispensing the coating liquid containing the water-insoluble drug from the dispensing tube to apply the coating liquid to the outer surface of the balloon.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: August 27, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Gotou, Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10376614
    Abstract: A medical device and a method of manufacturing the same which excels in lubricity under severe conditions are provided. The medical device according to the present disclosure is inserted into a living body. The medical device includes a resin coating layer that includes a maleic acid polymer substance and is provided on a surface of a base member. The resin coating layer is formed by covalently bonding the maleic acid polymer substance to a reactive functional group which exists on at least the surface of the base member of the medical device. A ratio of a peak height of carboxylate with respect to a total peak height of carboxylic acid ester and a carboxylic acid in the maleic acid polymer substance ranges from 1.2 to 1.7 when being measured through infrared spectroscopy (IR method).
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: August 13, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiromasa Kohama, Ayako Tokue
  • Patent number: 10369334
    Abstract: A balloon coating method for forming a coating layer on the outer surface of a balloon of a balloon catheter includes: inserting a core member into a guide wire lumen penetrating the balloon, disposing a proximal portion of the core member on a proximal side of a region of inflation of the balloon, with a distal portion of the core member protruded distally beyond a distal opening portion of the guide wire lumen, and fixing by clamping together with the core member a part of the balloon catheter that is on a distal side of the region of inflation; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to apply the coating liquid to the outer surface of the balloon.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: August 6, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Gotou, Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10371965
    Abstract: The present invention relates to a hydrogel contact lens having a wet surface, and a manufacturing method therefor and, more specifically, to a hydrogel contact lens and a manufacturing method therefor wherein the hydrogel contact lens satisfies basic physical properties of a hydrogel contact lens and has excellent wettability by forming a hydrophilic surface layer of an interpenetrating polymer network (IPN) structure on a surface of the hydrogel contact lens.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: August 6, 2019
    Assignee: INTEROJO INC.
    Inventors: Soo Chang Lee, Kyung Hee Oh
  • Patent number: 10330951
    Abstract: Embodiments of the technology relate to a contact lens having a core that is coated by a hydrogel layer, and to methods of making such a lens. The coated lens can include a rigid gas permeable contact lens. The coated lens can also include a hybrid silicone and rigid gas permeable contact lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core with a water equilibrium constant of less than about 2% comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population of one or more species.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: June 25, 2019
    Assignee: Tangible Science, LLC
    Inventors: Karen L. Havenstrite, Victor Wayne McCray, Brandon McNary Felkins, Paul A. Cook
  • Patent number: 10314748
    Abstract: A wound dressing product that includes a substrate layer having an upper surface and a lower surface; a tacky silicone coating composition present on the upper surface and on the lower surface; and upper and lower release sheets covering the substrate and the tacky silicone coating composition on the upper and lower surfaces, respectively, and adhered to the surfaces by the tacky silicone coating composition, wherein the upper surface is less tacky than the lower surface whereby the upper release sheet can be removed from the upper surface more readily than the lower release sheet can be removed from the lower surface. Also provided are methods for making such dressings.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: June 11, 2019
    Assignee: KCI USA, INC.
    Inventors: Deborah Addison, Sally Stephens, Rachel Hadley
  • Patent number: 10266139
    Abstract: In one embodiment, a vehicular monitoring and controlled response system includes a substance having a plurality of particles dispersed therein, the particles being tunable in response to an external stimulus; a sensor for measuring a disruption to a vehicle; and a computing device in communication with the sensor and the vehicle. The computing device has non-transitory computer readable medium with computer executable instructions stored thereon executed by a digital processor to analyze data received by the sensor; determine a magnitude of the external stimulus based on the data received by the sensor; and activate the external stimulus.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 23, 2019
    Assignee: Newtonoid Technologies, L.L.C.
    Inventors: Fielding B. Staton, David Strumpf
  • Patent number: 10266445
    Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with having a stable coating thereon. A method of the invention comprises a water-based coating process (step) for forming a relatively-stable base coating of a homo- or copolymer of acrylic acid or C1-C3 alkylacrylic acid onto a silicone hydrogel contact lens made from a lens formulation comprising from about 35% to about 60% by weight of N-vinylpyrrolidone.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: April 23, 2019
    Assignee: Novartis AG
    Inventors: Bradley Quinter, Troy Vernon Holland, Yash Kapoor
  • Patent number: 10245355
    Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: April 2, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Donald Ingber, Daniel C. Leslie, Michael Super, Alexander L. Watters, Anna Waterhouse
  • Patent number: 10239089
    Abstract: An apparatus for enrobing a product portion can include a polymer spray head arranged to direct a plurality of polymeric fibers in an upward direction and levitate product portions in a polymer enrobing zone above the polymer spray head. Polymeric fibers produced by the polymer spray head can wrap around the product portions levitated in the polymer enrobing zone to create an enrobed product. Side guide structure(s) and/or air knife(s) can be provided adjacent to the polymer enrobing zone to inhibit levitated product portions from falling out of the polymer enrobing zone and/or to guide levitated product portions along a desired path. Exemplary enrobed products include smokeless tobacco products.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: March 26, 2019
    Assignee: Altria Client Services LLC
    Inventors: James David Evans, Andrew Nathan Carroll, Shannon Maxwell Black
  • Patent number: 10213531
    Abstract: The invention concerns a method for coating a vascular endoprosthesis, wherein the vascular endoprosthesis is at least partially wetted with a first solution of an active ingredient and the areas of the vascular endoprosthesis at least partially wetted with the first solution of the active ingredient are at least partially wetted with a liquid containing water and/or at least an alcohol. The additional wetting with a liquid containing water/alcohol imparts a different consistency to the active ingredient layer, specifically making it is less transparent and lacquer-like and more chalklike and opaque. It has been found that such an active ingredient layer provides better transfer of the active ingredient to the blood vessels in which the vascular endoprosthesis is implanted.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: February 26, 2019
    Assignee: AACHEN SCIENTIFIC INTERNATIONAL PTE. LTD.
    Inventor: Alexander Ruebben