Device For Creating Or Holding Open An Unnatural Opening In A Membrane Or Organ (e.g., Syringe, Scalpel, Drainage Tube) Patents (Class 427/2.28)
  • Patent number: 10967134
    Abstract: A needle tube having a needle tip for puncturing skin; a needle hub; and a fluid-draining portion for enabling draining of a medicine. The needle hub includes: a retention part (first member) for retaining the needle tube; an insertion part into which the output portion of a syringe is inserted; and a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when a living body is punctured with the needle tube. The fluid-draining portion is disposed in the skin contact portion of the needle hub and enables a user to drain the medicine that has spilled when removing air and is held in the skin contact portion.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: April 6, 2021
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yoichiro Iwase, Junichi Ogawa, Kouichi Tachikawa
  • Patent number: 10766920
    Abstract: Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 8, 2020
    Assignee: NEUPHARMA, INC.
    Inventor: Xiangping Qian
  • Patent number: 10625298
    Abstract: Provided are a dip coating device which minimizes attachment of a coating material to a member to which a member to be coated is fixed, thereby facilitating coating of the member to be coated and a method for producing a coated member which is obtained by dip coating a member to be coated with a coating material. The dip coating device 10 of the present invention for coating a member to be coated 20 with a coating material 70, comprises a reservoir 30 that stores a coating material 70, a first fixing part 40 that holds a member to be coated 20, and a second fixing part 50 directly or indirectly provided on a wall 31 of the reservoir 30, wherein the first fixing part 40 and the second fixing part 50 magnetically attract to each other.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 21, 2020
    Assignee: KANEKA CORPORATION
    Inventor: Takuro Koda
  • Patent number: 10617794
    Abstract: Provided herein are methods comprising the use of a macroinitiator and application protocols to apply a hydrophilic coating to latex, or natural rubber, and compositions resulting from such methods. This coating results in e.g., an increased sense of lubrication when in contact with water or an aqueous solution.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: April 14, 2020
    Assignees: Trustees of Boston University, Boston Medical Center Corporation
    Inventors: Mark W. Grinstaff, Stacy L. Chin, Ruiqing Xiao, Benjamin Goldman Cooper, Karen Buch, Ducksoo Kim
  • Patent number: 10596355
    Abstract: A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A coating is disposed on the outer surface of the expandable and collapsible structure. The coating includes a bioactive agent. A sleeve is disposed over the coating. The sleeve is adapted to expand between a compressed state and an enlarged state and to return to the compressed state. The sleeve defines a plurality of openings in the compressed state. An outer diameter of the coating is less than an outer diameter of the sleeve when the expandable and collapsible structure is in the contracted state and greater than the outer diameter of the sleeve when the expandable and collapsible structure is in the dilated state.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: March 24, 2020
    Assignee: Surmodics, Inc.
    Inventor: Ralph A. Chappa
  • Patent number: 10463420
    Abstract: An electrosurgical device coated an epoxy modified rigid silicone powder coating. This coating is applied to the surfaces of an electrosurgical device minimize the build-up of charred tissue (i.e., eschar) on the surfaces of the electrosurgical device.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 5, 2019
    Assignee: Innovatech LLC
    Inventor: Bruce Nesbitt
  • Patent number: 10259009
    Abstract: A balloon coating method and a balloon coating apparatus are disclosed by which the thickness and/or morphological form of a drug in a coating formed on a balloon can be appropriately set. The balloon coating method can include moving a coating section for applying a coating liquid containing a drug relative to the balloon in the direction of an axis, while rotating the balloon about the axis of the balloon, thereby to apply the coating liquid to an outer surface of the balloon; detecting the distance of a dried part where the coating liquid applied to the outer surface of the balloon has been dried from the coating section; and controlling moving velocity of the coating section relative to the balloon in such a manner that the distance of the dried part from the coating section is maintained at a preliminarily set designated distance.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: April 16, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Eisuke Furuichi, Hiroshi Goto
  • Patent number: 10238773
    Abstract: The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: March 26, 2019
    Assignee: MiMedx Group, Inc.
    Inventors: Mengyan Li, Thomas J. Koob
  • Patent number: 9585846
    Abstract: The present invention relates to an anti-microbial composition and method of use thereof. In particular, the present invention relates to an anti-microbial composition comprising farnesol and cetrimide.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: March 7, 2017
    Assignee: Wild Child
    Inventor: John Found
  • Publication number: 20150141989
    Abstract: A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.
    Type: Application
    Filed: October 17, 2014
    Publication date: May 21, 2015
    Inventors: Warren P. Heim, James Brassell
  • Patent number: 9034415
    Abstract: The present invention provides improved medical devices for use in surgical procedures and methods for manufacturing improved medical devices. In some embodiments, the improved medical devices can include improved surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the improved surgical needles can be manufactured with two or more different coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Improved methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: May 19, 2015
    Assignee: Ethicon, Inc.
    Inventors: Robert Maurer, S. Neil Bar, Eric Hinrichs, Michael Hamilton, Thomas Wilkes
  • Publication number: 20150112282
    Abstract: The present invention relates to a method for manufacturing a hollow microneedle for subretinal injection or extraction. The microneedle for subretinal injection or extraction is made of metal, thereby providing the strength and force for penetrating the sclera and retina. Due to the length and the angle of curvature, the microneedle for subretinal injection or extraction of the present invention can reach a suitable subretinal site, such as the midperiphery at which optic nerves are accumulated, and thus the present invention is effective for delivering a drug and can enhance the effectiveness of the drug.
    Type: Application
    Filed: April 9, 2013
    Publication date: April 23, 2015
    Inventors: Hyung Il Jung, Chang Yeol Lee, Kwang Lee, Sung Ho Lee, Yong Sung You
  • Publication number: 20150112026
    Abstract: The invention relates to certain mixtures made of PE and COC, in particular for use in medical materials, so as to reduce the frictional forces.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 23, 2015
    Inventor: Alwin Schwitzer
  • Publication number: 20150104560
    Abstract: A radiotherapy method, comprising positioning a predetermined amount of a radionuclide selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220, in proximity to and/or within a tumor of a subject, for a predetermined time period. The predetermined amount and the predetermined time period are selected sufficient for the radionuclide to administering a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor.
    Type: Application
    Filed: November 24, 2014
    Publication date: April 16, 2015
    Inventors: Itzhak KELSON, Lior Arazi
  • Patent number: 8998679
    Abstract: Methods of treating the polymeric surfaces of a stent with a fluid including a solvent for the surface polymer are disclosed.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: April 7, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Bin Huang, David C. Gale, Daniel Castro, Timothy A. Limon
  • Patent number: 8974622
    Abstract: A medical device consists of a stent having a first surface and a second surface parallel to the first surface; a single expanded polytetrafluoroethylene (ePTFE) layer contacting the first surface of the stent; and an elastomeric layer applied to at least one surface of the stent. In at least one embodiment, the elastomeric layer is silicone. In at least one embodiment, the medical device is manufactured by positioning the ePTFE layer such that a first surface of the ePTFE layer contacts a first surface of the stent to form a stent-ePTFE assembly; and applying an elastomeric solution to the first surface of the ePTFE layer and at least one surface of the stent.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: March 10, 2015
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Claude Clerc, Gerald Fredrickson, Ralph Barry, Paul Norton, Kurt Geitz, Mike Madden
  • Patent number: 8962062
    Abstract: A method of manufacturing an end effector for a surgical instrument includes providing a substrate wherein at least an outer periphery of the substrate is formed from an electrically-insulative material. The method further includes forming at least one ridge on the outer periphery of the substrate and depositing an electrically-conductive material onto the at least one ridge to form at least one electrode.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: February 24, 2015
    Assignee: Covidien LP
    Inventors: Ronald J. Podhajsky, William S. Darrow, Kristel L. Ambrosius
  • Patent number: 8956684
    Abstract: Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: February 17, 2015
    Assignee: Abbott Medical Optics Inc.
    Inventors: Harish Makker, Can Hu, Michael D. Lowery
  • Patent number: 8940356
    Abstract: A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: January 27, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Victoria M. Gong, Stephen D. Pacetti, Anthony S. Andreacchi, Michael Leonard, Binh T. Nguyen, John Stankus, Dan Cox
  • Patent number: 8940358
    Abstract: System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device is provided to determine the distance to the surface of the expandable member at a corresponding location and relays the information to a controller or the like to maintain a substantially fixed distance between the outlet of the applicator and the surface of the expandable member when in alignment with the corresponding location.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: January 27, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Binh Nguyen, Randy Shen
  • Patent number: 8936827
    Abstract: A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and wherein at a temperature of 30° C. and at one atmosphere, the composition may be in a solid state or semi-solid state.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: January 20, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 8920870
    Abstract: A catheter comprising an outer shaft comprising a first section of electroactive polymer. The first section of electroactive polymer affecting either the flexibility of the catheter or the steerability of the catheter.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: December 30, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Jan Weber
  • Patent number: 8911817
    Abstract: A method and apparatus for coating catheters or balloon catheters is disclosed in which the catheter or balloon catheter is radially surrounded completely or almost completely at a constant distance by a device that applies a coating solution so that the coating solution completely fills the space between the catheter or balloon catheter and the device and thus completely surrounds the catheter or balloon catheter, relative motion is effected between the device and the catheter or balloon catheter in the axial direction across the surface of the catheter or balloon catheter multiple times, and partial drying of the applied coating solution occurs between the individual coating stages.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: December 16, 2014
    Assignee: DOT GmbH
    Inventors: Hans-Georg Neumann, Mischa Buhrmeister
  • Publication number: 20140336643
    Abstract: A tissue-resecting probe includes an elongated outer sleeve extending about an axis to a distal housing having a first window for receiving tissue. An edge of the first window has a dielectric surface. A rotatable inner sleeve has a second window, and at least a portion of an edge of the second window provides a first polarity electrode. Rotation of the inner sleeve within the outer sleeve moves the probe between window-open and window-closed configurations to resect tissue.
    Type: Application
    Filed: May 12, 2014
    Publication date: November 13, 2014
    Applicant: ARQOS Surgical, Inc.
    Inventors: Benedek Orczy-Timko, Csaba Truckai, Aaron Germain
  • Patent number: 8883245
    Abstract: A novel silicone coating process for surgical needles is disclosed. Coating solutions are applied to a surgical needle and a stream of air is directed at the needle in a direction substantially parallel to the central longitudinal axis of the distal section of the needle, providing superior coatings and performance.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 11, 2014
    Assignee: Ethicon, Inc.
    Inventors: Frank Cichocki, Duan Li Ou, Brian Blasic
  • Publication number: 20140323966
    Abstract: The present disclosure describes a gastric jejunal tube having a gastric lumen and a jejunal lumen that run the length of the tube. The cross-sectional sizes of the lumens change from above to below the most distal gastric port. A method of making the gastric jejunal tube is also described.
    Type: Application
    Filed: November 25, 2013
    Publication date: October 30, 2014
    Inventors: Katherine L. Dziak, Donald J. McMichael, Michael A. Schmidt
  • Patent number: 8858863
    Abstract: The present invention relates to a balloon (1) for treating stenosis and the method for obtaining this balloon. The method comprises the steps of: bringing the balloon in the deployed configuration; placing a plurality of stylets (17) that are arranged in the axial direction along the outer wall (10) of the balloon; pushing the stylets towards the balloon core (11) in the radial direction such as to form a plurality of laps (12); laying the laps about the core in the tangential direction such as to lay each lap on an adjacent stylet; removing the stylets such as to form a plurality of cavities (13) comprised between each lap and the balloon core; filling the cavities with the drug.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: October 14, 2014
    Assignee: Invatec S.p.a.
    Inventor: Andrea Venturelli
  • Patent number: 8828069
    Abstract: A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: September 9, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Jessica Reneé´ DesNoyer, Thierry Glauser, Stephen D. Pacetti, Syed Faiyaz Ahmed Hossainy
  • Publication number: 20140248419
    Abstract: A method of coating an exterior surface of the elongate object with the coating material includes holding the elongate object lengthwise in the elongate chamber, mixing the pressurized air and the coating material to form a mist, and coating the exterior surface while directing the mist around the exterior surface and toward the outlet of the elongate chamber.
    Type: Application
    Filed: May 16, 2014
    Publication date: September 4, 2014
    Applicant: NORDSON CORPORATION
    Inventors: Andreas Döker, Thomas Wanka, Michael Wilczek
  • Patent number: 8821437
    Abstract: Biological materials such as vaccines can be stabilized in certain glassy materials soluble in water. It has been proposed to form these glassy materials as a powder suspended in a non-aqueous liquid for injection into a patient. This method is complicated by the need to find suitable compatible liquids and to stop the glassy particles from congregating in liquid. These problems have been obviated by supporting the glassy material on a porous membrane remote from the eluant. When the biological material requires administration, the eluant can be passed across the membrane dissolving the glass and causing the substance to be carried by the liquid into the patient.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: September 2, 2014
    Assignee: NOVA Bio-Pharma Technologies Limited
    Inventors: Samodh de Costa, Bruce Roser, Shevanti Sen
  • Publication number: 20140242259
    Abstract: A method for smoothing sharp areas on the bevel heel of a cannula comprises initially grinding a cannula end portion to form a bevel with a distal tip and an axially opposite heel. An ultraviolet-curable adhesive is applied to the heel. The heel is then exposed to ultraviolet radiation and is ultimately cured. It will be appreciated that the smoothing is accomplished without blasting glass beads at the cannula.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 28, 2014
    Inventor: Christopher S. Young
  • Patent number: 8802184
    Abstract: A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first fluid into a second fluid having a suspension of nano-constructs; and removing the stent from the second fluid and allowing the first and second fluid to be removed such that the nano-constructs are carried by the stent for in vivo application of the constructs to a target location of a mammalian subject. The nano-constructs can be attached to the surface of the stent, can be attached to a surface of the coating of the stent, can be embedded into the stent, or can be embedded into the coating.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: August 12, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Dariush Davalian, Jinping Wan, Troy Carter, Charles Silvis
  • Publication number: 20140221934
    Abstract: The invention relates to the use of plasma treated silicone oil as a coating in a medical injection device (1) comprising a barrel (2) and a stopper (3) in gliding engagement within the barrel, for limiting the number of particles present on the surface of the coating and for limiting the number of particles released in a pharmaceutical composition contained in the injection device.
    Type: Application
    Filed: September 27, 2012
    Publication date: August 7, 2014
    Applicant: Becton Dickinson France
    Inventors: Sebastian Janvier, Paolo Mangialli, Sebastian Jouffray, Cedric Foucher, Yves Enfoux
  • Patent number: 8795030
    Abstract: Methods of treating the polymeric surfaces of a stent with a fluid including a solvent for the surface polymer are disclosed.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: August 5, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Bin Huang, David C. Gale, Daniel Castro, Timothy Limon
  • Patent number: 8784928
    Abstract: Methods for the deposition of silver-comprising films on nonconducting substrates, and, more particularly, to deposition of such films that are very thin, are provided. The surface of nonconducting substrates is modified with a superabsorbent polymer to increase silver deposition when compared to a non-modified surface. Also provided are films produced using a swelling agent, whereby porosity of the surface of the nonconducting substrate is increased, thereby permitting increased silver deposition when compared to an unmodified surface.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: July 22, 2014
    Assignee: C. R. Bard, Inc.
    Inventors: Richard N. Terry, Fung Bor Chen, Zhihui Yin
  • Patent number: 8771781
    Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: July 8, 2014
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Patent number: 8758847
    Abstract: A medical device includes a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends. The tubular device includes an inner liner including a coating on an inner surface thereof, a reinforcing layer surrounding at least a portion of the liner; and an outer layer surrounding the reinforcing layer and inner liner. The liner and outer layer may include multiple sections having different properties than one another, adjacent sections attached together by seams, which may be offset from one another. Apparatus and methods for making tubular devices with coated liners are also provided.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: June 24, 2014
    Assignee: Aust Development, LLC
    Inventors: Stephen Arie Leeflang, Christian Scott Eversull
  • Publication number: 20140170299
    Abstract: Coated microneedle devices and methods of making such devices are provided. In one aspect, a method for coating includes providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which includes at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure. The coating liquid may include a viscosity enhancer and surfactant. Microneedles having heterogeneous coatings, pockets, or both are also provided.
    Type: Application
    Filed: February 20, 2014
    Publication date: June 19, 2014
    Applicant: Georgia Tech Research Corporation
    Inventors: Harvinder Singh Gill, Mark R. Prausnitz
  • Patent number: 8747940
    Abstract: Methods for forming a “coating gradient” on medical devices, such as a balloon catheter or guidewire are disclosed. The balloon portion of the catheter has a protective covering initially placed over it to prevent the balloon from receiving a first hydrophilic coating. After a first hydrophilic coating is applied, the protective covering is removed. A second hydrophilic coating could be applied to the catheter. A guidewire having less lubricity at the distal end portion also can be created. A first hydrophilic coating is applied to the elongated shaft and distal shaft section of the guidewire. After the first hydrophilic coating cures, the first hydrophilic coating is removed from a portion of the distal shaft section of the guidewire. A second hydrophillic coating can then be applied to the elongated shaft and distal shaft section of the guidewire. The second hydrophilic coating can be allowed to cure.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: June 10, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Jeong S. Lee, Kenneth L. Wantink
  • Patent number: 8741380
    Abstract: A fine metal structure having its surface furnished with microprojections of high strength, high precision and large aspect ratio; and a process for producing the fine metal structure free of defects. There is provided a fine metal structure having its surface furnished with microprojections, characterized in that the microprojections have a minimum thickness or minimum diameter ranging from 10 nanometers to 10 micrometers and that the ratio between minimum thickness or minimum diameter (D) of microprojections and height of microprojections (H), H/D, is greater than 1.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: June 3, 2014
    Assignee: Hitachi, Ltd.
    Inventors: Hiroshi Yoshida, Haruo Akahoshi, Akihiro Miyauchi, Masahiko Ogino
  • Patent number: 8679573
    Abstract: An apparatus includes a piezoelectric print head capable of ejecting a droplet of a coating substance towards a stent strut, a sensor capable of sensing a parameter of the droplet, and a controller, communicatively coupled to the print head and the sensor, capable of determining if the parameter of the droplet meets a requirement. A method includes ejecting a droplet of a coating substance towards a stent strut with a piezoelectric print head, sensing a parameter of the droplet, and determining whether the parameter of the droplet meets a requirement.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: March 25, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jason Van Sciver, Greg Teaby, Phil Foreman, Manish Gada
  • Patent number: 8679572
    Abstract: A coated stent (20) for use in a medical procedure and methods of manufacturing the coated stent (20) are described. A stent component (30) has an expanded state in which an inner diameter (ds) of the stent (30) is less than or equal to an outer diameter (dc2) of a coating (40), thereby causing an inner surface (35) of the stent (30) to engage the outer surface (42) of the coating (40). In one exemplary method of manufacture, the stent (30) is disposed over the coating (40) when the coating (40) is provided with a first, smaller outer diameter (dc1). The coating (40) then is radially expanded to a second, larger outer diameter (dC2), which is greater than or equal to the inner diameter (ds) of the stent (30), to cause the outer surface (42) of the coating (40) to engage the inner surface (35) of the stent (30).
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: March 25, 2014
    Assignee: Cook Medical Technologies, LLC
    Inventor: Fred T. Parker
  • Patent number: 8679571
    Abstract: A method for producing a bioactive surface on an endoprosthesis, or on the balloon (3) of a balloon catheter (1) is described, wherein the surface (15) of the endoprosthesis, or the surface (4) of the balloon (3) is softened. The surface (15) of the endoprosthesis, or the surface (4) of the balloon (3) is moistened with a solution (6) of an active ingredient (7), and the solvent (8) is separated from the active ingredient (7). In addition, a balloon (3) of a balloon catheter (1) is disclosed, which comprises an uncoated surface (4), wherein an unencapsulated active ingredient (7) is embedded at least partially into the material of the surface (4). Furthermore, a balloon catheter (1) is described, which comprises a balloon (3) according to the invention. In addition, an endoprosthesis, particularly a polymer stent is described, which comprises an uncoated surface (15), wherein an active ingredient (7) is embedded at least partially into the material of the surface (15).
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: March 25, 2014
    Inventor: Alexander Rübben
  • Patent number: 8673387
    Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: March 18, 2014
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, William J. Bourdeau, Neal E. Fearnot
  • Patent number: 8673388
    Abstract: A substrate is modified by exposing the substrate to a densified fluid. The substrate may be a polymer or a metal alloy, and the densified fluid may be carbon dioxide. Uses of such substrate modification include impregnation of the substrate with one or more drugs, impregnation of microcellular particles, surface modification of the substrate, and formation of microcellular compositions.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 18, 2014
    Assignee: Cook Medical Technologies LLC
    Inventors: Jian-Lin Liu, Bruce J. Demars
  • Publication number: 20140072518
    Abstract: The present disclosure is directed to a class of fluorinated copolymers, such as a PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.
    Type: Application
    Filed: September 12, 2013
    Publication date: March 13, 2014
    Applicant: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 8668972
    Abstract: Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing stiction between such surfaces or between a coated surface and another surface.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: March 11, 2014
    Assignee: GVD Corporation
    Inventors: Hilton G. Pryce Lewis, Neeta P. Bansal, Erik S. Handy
  • Publication number: 20140066842
    Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.
    Type: Application
    Filed: March 6, 2012
    Publication date: March 6, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Ying Zhang, Kristen J. Hansen, Amy S. Determan
  • Patent number: 8658239
    Abstract: The present invention relates to compositions which are suitable for selective filling or selective coating of folds of a folded balloon, and especially relates to compositions of a contrast agent and an active agent in a solvent for filling of folds of a folded catheter balloon as well as to methods for selective filling or selective coating of folds of a folded catheter balloon and to filled or coated folded catheter balloons which can be obtained according to one of these methods.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: February 25, 2014
    Assignee: B. Braun Melsungen AG
    Inventors: Armin Von Holst, Christoph Heitzmann
  • Publication number: 20140052076
    Abstract: The present invention provides rubber sealing members having an exterior surface adapted to sealingly engage an inner surface of a chamber of a medical device, the exterior surface of the sealing member having a coating thereon prepared from a curable composition including: (a) a first organopolysiloxane having at least two alkenyl groups; and (b) a second organopolysiloxane having at least two pendant hydrogen groups, the second organopolysiloxane being different from the first organopolysiloxane, wherein at least one of the first organopolysiloxane, the second organopolysiloxane or an optional third organopolysiloxane of the curable composition comprises a fluoro group.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Becton, Dickinson and Company
    Inventors: Xia Zhao, Yongming Liu