Fluid Barrier Or Fluid Transporting Product, Other Than Merely Absorbing (e.g., Surgical Glove, Condom, Lined Diaper, Membrane Filter, Iv Tubing, Cannula, Dialysis Membrane, Urinary Catheter) Patents (Class 427/2.3)
  • Patent number: 11135370
    Abstract: The invention relates to a lubricant coating (5) for a medical injection device (1), comprising successively: —a bottom layer (50) in contact with the medical device surface (21) of the container to be lubricated, comprising a mixture of cross-linked and non-cross-linked poly-(dimethylsiloxane), —an intermediate layer (51) consisting essentially of oxidized poly-(dimethylsiloxane) and having a thickness comprised between 10 and 30 nm and, —a top layer (52) consisting essentially of non-cross-linked poly-(dimethylsiloxane) and having a thickness of at most 2 nm. The invention also relates to a medical injection device comprising such a lubricant coating, and a manufacturing process for said coating.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: October 5, 2021
    Assignee: Becton Dickinson France
    Inventors: Cédric Foucher, Virginie Santucci-Aribert
  • Patent number: 11123491
    Abstract: A package including a vessel wherein at least a portion of the vessel wall is made of a double wall material is disclosed. The double wall material comprises an interior polymer layer enclosed by an exterior polymer layer and one of the polymer layers is a layer made of cyclic olefin polymer (COP) resin. The package comprising the double wall, a CVD coating set on the wall, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: September 21, 2021
    Inventors: John T. Felts, Thomas E. Fisk, Robert S. Abrams, John Ferguson, Jonathan R. Freedman, Robert J. Pangborn, Peter J. Sagona
  • Patent number: 11097487
    Abstract: An additive manufacturing system includes an additive manufacturing (AM) device, a first sensor device, and a compute device. The AM device is configured to form a bulk component in a layer-by-layer manner, by at least iteratively depositing a first layer of raw material onto a working surface in a deposition chamber, consolidating the initial layer into an initial additive portion of the bulk component, then forming subsequent additive portions of the bulk component by depositing and consolidating a subsequent plurality of layers of the raw material onto the first additive portion. The first sensor device is configured to measure an actual composition of at least one first byproduct portion formed upon consolidation of one of the first or subsequent layers of raw material in the deposition chamber. The compute device includes a processor and a memory, and is communicatively coupled to the additive manufacturing device and first sensor device.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 24, 2021
    Assignee: Hamilton Sundstrand Corporation
    Inventors: Tahany Ibrahim El-Wardany, Joseph V. Mantese, Abhijit Chakraborty, Paul Attridge
  • Patent number: 10792710
    Abstract: Disclosed is a method for washing a smearing member, the method including: dropping a washing agent on a glass slide; and causing the smearing member to be in contact with the washing agent on the glass slide, to wash the smearing member.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 6, 2020
    Assignee: Sysmex Corporation
    Inventors: Mitsuo Yamasaki, Noriyuki Nakanishi, Masahiko Fukushima, Hiroyuki Koga
  • Patent number: 10569061
    Abstract: A balloon coating method is disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method includes an application step in which, where a pipe-shaped dispensing tube formed from a polyolefin for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the end portion side of the dispensing tube is placed in contact with the outer surface of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 25, 2020
    Inventors: Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10532133
    Abstract: The present disclosure relates to a coating for medical devices. The lubricious coating includes a primer layer and a top coating layer as well as methods of making and using the same. The primer layer includes a reaction cured product of a multifunctional acrylate and an acid functionalized monoacrylate. The top coating layer includes a reaction cured product of a mixture that includes a hydrophilic polymer comprising polyvinylpyrrolidone, an acid functionalized monoacrylate, and a hydrophilic monomer. The lubricious coating may be coated onto medical devices to form a sensing guide wire, an ultrasound imaging device, and an intravascular imaging device. Associated devices and methods are also provided.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: January 14, 2020
    Inventor: Tung-Liang Lin
  • Patent number: 10403911
    Abstract: Electrochemical cells, such as those present within flow batteries, can have an electrode and a bipolar plate in at least one half-cell interfacially bonded together with an electrically conductive adhesive. Bonding the bipolar plate to the electrode can decrease contact resistance and sometimes lessen the incidence of parasitic reactions in the electrochemical cell. Flow batteries containing these features can include: a first half-cell containing a first electrode in interfacial contact with a first bipolar plate, a second half-cell containing a second electrode in interfacial contact with a second bipolar plate, and a separator disposed between the first half-cell and the second half-cell. An electrically conductive adhesive interfacially bonds at least one of the first electrode to the first bipolar plate and the second electrode to the second bipolar plate. Each electrode maintains fluid communication with its corresponding bipolar plate.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: September 3, 2019
    Assignee: Lockheed Martin Energy, LLC
    Inventors: Srivatsava Venkataranga Puranam, Timothy B. Grejtak, Jeremy Loretz, Thomas H. Madden, Joseph Johannes Henricus Pijpers, Helen Elizabeth Vanbenschoten, Curtis Warrington
  • Patent number: 9937336
    Abstract: A method of manufacturing a conical-projections-sheet packaging body includes forming a plurality of conical-recess parts on a conical-projections forming sheet; forming, by supplying a conical-projections material to the conical-projections forming sheet, a conical-projections sheet including a base sheet and a plurality of conical projections formed on a surface of the base sheet and disposed inside the plurality of conical-recess parts; forming a plurality of sets of the conical-projections forming sheets and the conical-projections sheets by punching out the conical-projections forming sheets and the conical-projections sheets; and using a package member to package a set of the conical-projections sheets and the conical-projections forming sheets tightly adhered to one another. Thus, the plurality of conical projections of the conical-projections sheet are protected.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: April 10, 2018
    Inventors: Shinya Yamada, Osanobu Akao, Masateru Chiyama
  • Patent number: 9827377
    Abstract: A gasket includes a flexible packing portion having a recess attached to a coupler of a plunger rod, and a core member harder than the packing portion. The recess has an internal circumferential surface with an internally threaded portion capable of being screwed on and thus engaging with an externally threaded portion provided on an external circumferential surface of the coupler. The core member has a helical shape defining the internal circumferential surface of the recess and the internally threaded portion provided on the internal circumferential surface. The packing portion defines a sliding surface brought into contact with an inner circumferential surface of a barrel, and the packing portion also covers an outer circumferential surface of the core member.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: November 28, 2017
    Inventors: Toshiyuki Takai, Motonori Nakamura
  • Patent number: 9744303
    Abstract: Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: August 29, 2017
    Assignee: Merit Medical Systems, Inc.
    Inventors: Philippe Reb, Peter C. Sutcliffe
  • Patent number: 9603980
    Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: March 28, 2017
    Assignee: Cardinal Health Switzerland 515 GmbH
    Inventor: Jonathon Z. Zhao
  • Patent number: 9468726
    Abstract: A prefilled syringe for injecting medicament into a patient includes a barrel constructed of a polymeric material, a cannula and a hub. The barrel has a diameter, a longitudinal axis, a proximal end and a distal end. The cannula has a proximal end and a tip opposite the proximal end. The proximal end of the cannula is fixed to the distal end of the barrel. The cannula is positioned generally coaxially with the longitudinal axis. The hub is integrally formed with the distal end. The hub includes a rib section and a cap. The rib section has a generally cruciform cross-section taken along a rib plane. The rib plane is generally perpendicular to the longitudinal axis. The cap has a generally U-shaped cross-section taken along a longitudinal plane. The longitudinal plane is generally parallel to the longitudinal axis.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 18, 2016
    Inventor: Jon Tyler Lundquist
  • Patent number: 9204981
    Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: December 8, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Yung-Ming Chen, Jason Van Sciver, Syed F. A. Hossainy, Stephen Pacetti
  • Patent number: 9127091
    Abstract: The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: September 8, 2015
    Assignee: BioInteractions, Ltd.
    Inventors: Ajay K. Luthra, Shivpal S. Sandhu, John O. Hudson
  • Publication number: 20150140344
    Abstract: Processes for coating medical devices are provided herein. The processes include contacting a substrate with a sulfur-functional silane and an additional silane. The resulting coating includes a silane layer having improved adherence to the medical device, covering a greater area.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 21, 2015
    Inventors: Xiaodong Ma, Junwei Li, Min-Shyan Sheu, Anastasia Righter, Ariana Gilmore
  • Publication number: 20150122269
    Abstract: A topsheet made of a fibrous web or a perforated film and having a clear top layer containing about 5% to about 50% of jade particles. The jade particles having a mean diameter of from about 50 to about 600 microns and an aspect ratio from about 1 to about 5. Also disclosed is method for manufacturing the topsheet, as well as absorbent articles and facial protection masks containing the topsheet.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 7, 2015
    Inventor: James W. CREE
  • Patent number: 9016281
    Abstract: A condom having an indicia disposed on the lower side of the roll when the condom is in the rolled configuration. Preferably, the indicia is a fluorescent marking disposed on the inner side of the condom disposed at a location so that, when the condom is in the rolled configuration, the indicia is visible from the lower side only. More preferably, the indicia is a ring-shaped marking extending about the inner side of the tubular body. In this configuration, a user holding a rolled condom can easily determine which is the upper side of the roll and which is the lower side of the roll. The user may then quickly orient the condom with the lower side facing toward the penis and unroll the condom in the proper direction.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: April 28, 2015
    Inventor: William Thomas Mistler
  • Publication number: 20150112424
    Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
    Type: Application
    Filed: August 29, 2014
    Publication date: April 23, 2015
    Inventors: James DeYoung, Doug Taylor, Jim McClain, Clint Smoke, Mike Cole
  • Publication number: 20150098976
    Abstract: Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 9, 2015
    Applicants: Agency For Science, Technology and Research, International Business Machines Corporation
    Inventors: Xin Ding, James L. Hedrick, Chuan Yang, Yi Yan Yang
  • Publication number: 20150100043
    Abstract: A medical probe includes a proximal section, a transition region, and a distal section. The proximal section includes a braid that is braided with a cross-braiding configuration. In the transition region, which follows the proximal section, the braid transitions between the cross-braiding configuration and a helical coiling configuration. In the distal section, which follows the transition region, the braid is coiled with the helical coiling configuration.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 9, 2015
    Inventors: Assaf Govari, Christopher Thomas Beeckler
  • Patent number: 8999427
    Abstract: The invention relates to a method for the impregnation of a product consisting of fibrous material and formed from a continuous web (22), the method comprising at least one first step of cutting out a specific zone (24) of the continuous web (22) and at least one second step of applying an impregnation product to the specific zone (24), the first and second steps being carried out simultaneously or virtually simultaneously.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: April 7, 2015
    Assignee: SCA Tissue France
    Inventor: Remy Ruppel
  • Publication number: 20150094682
    Abstract: A liquid absorbent structure is made by dry laying a fibrous web having incorporated therein a superabsorbent material, and applying an aqueous composite stabilizer to at least one surface of the web. The aqueous composite stabilizer imparts integrity to the resulting structure without substantially impairing the effectiveness of the superabsorbent material to absorb liquid while forming the absorbent structure without removing the water from aqueous composite stabilizer or drying out the absorbent structure. The absorbent composite absorbs the water from the aqueous composite stabilizer. The absorbent composite comprises about 70% by weight of a superabsorbent material.
    Type: Application
    Filed: February 21, 2014
    Publication date: April 2, 2015
    Applicant: Kimberly-Clark Worldwide, Inc.
    Inventors: David Arthur Fell, Steven Michael Hurley, Donald LeRoy Smith, Kendell Jean Williams, Nicholas Alan Kraft, Johanna Marie Buss, David John Paulson, Thomas Gerard Vercauteren, Sara Lynn Rosack, James George Van Himbergen
  • Patent number: 8986781
    Abstract: With the subject invention, a method is provided for preparing a filter membrane including the steps of dispersing a liquid which is generally hydrophobic into the pores of a porous membrane, and applying a solution containing lipids onto at least a first surface of the porous membrane containing the liquid. Advantageously, the subject invention allows for filter membranes to be prepared which can be stored for periods of time without degradation in performance. The subject invention may have applicability in various contexts, but is well-suited for preparing filter membranes for permeability screening, particularly Parallel Artificial Membrane Permeability Assay (PAMPA).
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: March 24, 2015
    Assignee: Corning Incorporated
    Inventors: Xiaoxi (Kevin) Chen, Charles L. Crespi
  • Publication number: 20150076054
    Abstract: In one embodiment described herein, a bodily fluid separation material is provided comprising a formed component capture region and a bodily fluid pass-through region. The pass-through region has structures with a reduced liquid leaching quality relative to than the capture region, wherein during separation material use, bodily fluid enters the capture region prior to entering the pass-through region. Optionally, a bodily fluid pass-through region has a reduced amount of liquid leaching material relative to than the capture region.
    Type: Application
    Filed: March 15, 2014
    Publication date: March 19, 2015
    Inventors: Samartha Anekal, Deborah Sloan
  • Publication number: 20150079142
    Abstract: Methods for inhibiting a biomaterial-associated thrombotic event comprise reducing the number of platelets that bind to the biomaterial, or inhibiting platelet activation, by attaching CD47 or the Ig domain thereof to the surface of the biomaterial. Methods of the present invention inhibit thrombi formation on or near a biomaterial that is on the surface of an implant, medical device, tube, or therapeutic delivery vehicle. Also provided are kits for practicing these methods and the modified biomaterials.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Inventors: Stanley J. Stachelek, Matthew J. Finley, Robert J. Levy
  • Patent number: 8957173
    Abstract: Disclosed is a respiration-assisting tube whereby tissue damages in vivo can be prevented and, as a result, inflammatory reactions and infections can be avoided. The respiration-assisting tube is developed based on the finding that adhesion of cells to a respiration-assisting tube can be inhibited by coating the respiration-assisting tube with a polymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC). Also, the respiration-assisting tube is developed based on the finding that, by coating a respiration-assisting tube with a polymer containing MPC, mucosa peeling and tissue damages, which occur after using the respiration-assisting tube, can be prevented and, as a result, inflammatory reactions can be avoided.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: February 17, 2015
    Assignees: Next21 K.K., The University of Tokyo, NOF Corporation
    Inventors: Yuichi Tei, Nobuo Sasaki, Shigeki Suzuki
  • Patent number: 8951595
    Abstract: A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: February 10, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: John Stankus, Mikael Trollsas, Syed Hossainy, Stephen Pacetti, Michael Ngo
  • Publication number: 20150038947
    Abstract: A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 ?m and/or a profile section height difference (Rdc (1-99%)) of at least 18 ?m. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Applicant: ASTRA TECH AB
    Inventors: Andrea SCHMID, Marie SVENSSON
  • Patent number: 8945914
    Abstract: Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: February 3, 2015
    Assignee: Sandia Corporation
    Inventors: Ulrich Y. Schaff, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch
  • Publication number: 20150031772
    Abstract: A coating comprised of a polymeric material and a bioactive agent where the properties of the casting solvent dictate the dispersion of the embedding bioactive agent. In preferred embodiments, controlled release of the bioactive agent is achieved by homogeneous dispersion of the bioactive agent within the coating. A further aspect of the invention is directed to formulations where the heterogeneous dispersion of the bioactive agent provides an initial rapid release of the bioactive agent. Methodology for production of coating formulations of the desired properties and the application of the coating to an article are also described.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 29, 2015
    Inventors: Mark Schallenberger, Ben Luchsinger, Todd Meyer, Helena Lovick
  • Patent number: 8940356
    Abstract: A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: January 27, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Victoria M. Gong, Stephen D. Pacetti, Anthony S. Andreacchi, Michael Leonard, Binh T. Nguyen, John Stankus, Dan Cox
  • Publication number: 20150024019
    Abstract: The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
    Type: Application
    Filed: May 25, 2011
    Publication date: January 22, 2015
    Inventors: Mahfuza B. Ali, Naiyong Jing, Valeri Lirine, Pradnya V. Nagarkar, Caroline M. Ylitalo, Nancy S. Lennhoff, Matthew T. Scholz, Ranjani V. Parthasarathy
  • Patent number: 8936827
    Abstract: A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and wherein at a temperature of 30° C. and at one atmosphere, the composition may be in a solid state or semi-solid state.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: January 20, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Publication number: 20150018962
    Abstract: A medical tube in which an intermediate layer composed of a composition containing (a), (b), and (c1) listed below and a lubricant layer composed of a composition containing (a), (b), and (c2) listed below are sequentially laminated on a surface of an insertion member to be inserted into a living body: (a) 1 to 35 weight % of at least one of aromatic diisocyanate, aliphatic diisocyanate, and alicyclic diisocyanate; (b) 1 to 35 weight % of trifunctional or higher functionality polyol; (c1) 30 to 98 weight % of polyalkylene glycol and/or monomethoxypolyalkylene glycol; and (c2) 30 to 98 weight % of polyalkylene glycol (including polyalkylene glycol larger in weight-average molecular weight than polyalkylene glycol in (c1)) and/or monomethoxypolyalkylene glycol (including monomethoxypolyalkylene glycol larger in weight-average molecular weight than monomethoxypolyalkylene glycol in (c1)), (where each of the glycols in (c1) and (c2) is diol).
    Type: Application
    Filed: January 25, 2013
    Publication date: January 15, 2015
    Inventors: Mariko Matsumoto, Yoichi Matsumura, Hidekazu Miyauchi
  • Publication number: 20150017317
    Abstract: In at least one embodiment of the present invention, a method for making an occluding device for occlusion of fluid flow through a lumen of a body vessel is provided. The method comprises attaching a coating to an embolization coil that is substantially straight. The coating is nominally strained on the substantially straight embolization coil. The embolization coil has a pre-curled tension to facilitate the embolization coil being curled within the lumen of the body vessel when deployed. The embolization coil is restrained from curling until deploying to reduce pre-deployment straining of the coating.
    Type: Application
    Filed: October 1, 2014
    Publication date: January 15, 2015
    Inventors: Gary Bradford Shirley, Sanket Nayanbhai Patel
  • Patent number: 8932345
    Abstract: Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: January 13, 2015
    Assignee: Cook Medical Technologies LLC
    Inventors: William F. Moore, Gary Bradford Shirley
  • Patent number: 8932664
    Abstract: A protective coating solution, liquid, gel, or film and a method of using such a material to provide a sterile covering for fingers, hands, arms or other selected skin surface for use as a glove substitute.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: January 13, 2015
    Inventor: Bradley P Bengtson
  • Publication number: 20140356900
    Abstract: Technologies are generally described for indwelling medical devices for detection of luminal catheter colonization. A substrate for use as an indwelling medical device includes an elevated biofilm releasing medium including a dye for release into urine on the occurrence of an elevated biofilm build-up on the substrate in the urine; and an elevated pH releasing medium including a dye on the substrate different from the dye used to detect biofilm build-up for release into urine on the occurrence of an elevated pH level in the urine. Methods of manufacture and use of the disclosed indwelling medical devices are also described.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 4, 2014
    Applicant: Empire Technology Development LLC
    Inventor: George Charles Peppou
  • Patent number: 8900652
    Abstract: A method of manufacturing a coated low-friction medical device, such as low-friction medical tubing, including applying a coating to one or more selected portions of a surface of low-friction medical tubing to indicate at least one marking formed along the surface of the low-friction medical tubing, and simultaneously or substantially simultaneously: (a) curing the applied coating to a designated temperature (which is above the temperature at which the low-friction medical tubing begins to decompose and shrink) to adhere the applied coating to the surface of the low-friction medical tubing, (b) utilizing one or more anti-shrinking devices to counteract or otherwise inhibit the shrinking of the low-friction medical tubing, and (c) exhausting any harmful byproducts resulting from curing the low-friction medical tubing to a temperate above the temperature at which the low-friction medical tubing begins to decompose.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: December 2, 2014
    Assignee: Innovatech, LLC
    Inventors: Adino D. Caballero, Bruce Nesbitt, Charles Berkelhamer, George F. Osterhout
  • Publication number: 20140350457
    Abstract: Microneedle devices are spray coated by nozzles which jet dispense dots onto the individual needles of a microneedle device from a spray nozzle which is angled with respect to the plane of the microneedle device. An angle of between 70° and 45° is preferred and can be achieved by providing the microneedle devices on a support which is inclined at 20° to 45° to the horizontal and using a spray nozzle with a vertical axis.
    Type: Application
    Filed: September 17, 2012
    Publication date: November 27, 2014
    Inventor: Dionysios Douroumis
  • Patent number: 8889212
    Abstract: The present invention relates to a method of treating an article surface. The method includes removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles including a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also includes delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: November 18, 2014
    Assignee: EnBio Limited
    Inventors: John Gerard O'Donoghue, Donncha Haverty
  • Publication number: 20140330198
    Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
    Type: Application
    Filed: November 30, 2012
    Publication date: November 6, 2014
    Inventors: Ying Zhang, Percy T. Fenn, Peter R. Johnson
  • Publication number: 20140328895
    Abstract: The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising: a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic-pH sensitive polymer is larger than 1.
    Type: Application
    Filed: March 25, 2012
    Publication date: November 6, 2014
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Michael Friedman, Doron Steinberg, Eran Lavy
  • Publication number: 20140328998
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Application
    Filed: May 7, 2014
    Publication date: November 6, 2014
    Applicant: SurModics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Publication number: 20140326250
    Abstract: A condom comprises, on one or more surfaces thereof, a self-lubricating coating comprising a dry powder having a particle size of 300 microns or less. The self-lubricating coating becomes lubricious when the coating comes into contact with a liquid environment. A method of making a self-lubricating condom comprises providing a dry condom and coating said condom, on one or more surfaces thereof, with a self-lubricating coating comprising a dry powder. The invention also provides the use of a dry powder such as xanthan gum to provide a self-lubricating coating for a condom.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 6, 2014
    Inventors: Andrew Richard Arnold, Rohaida ABD Majid, Tossapom Tosanun
  • Patent number: 8876732
    Abstract: Sampling device for obtaining a sample of an analyte, comprising a feed line (30) and a discharge line (40) as well as an analyte feed chamber (13) in fluidic connection between the feed line and the discharge line, the analyte feed chamber having an opening (14) which is provided with an analyte-permeable membrane (15) to allow the analyte to pass through from a region outside the analyte feed chamber into the analyte feed chamber, the surface area of the opening of the analyte feed chamber being at most 400 times the minimum cross-sectional surface area of the discharge line, more preferably at most 100 times and most preferably 50 to 80 times the minimum cross-sectional surface area of the discharge line. This device will reduce the dead time between the passage of the analyte through the membrane and the detection of said analyte at the sensor.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: November 4, 2014
    Assignee: Trace Analytics GmbH
    Inventors: Wolfgang Kuennecke, Michael Hartlep, Jens Giesenberg, Matthias Lehmann
  • Patent number: 8869799
    Abstract: A male contraceptive device includes a condom-like sheath that is placed over the male genital member and has a flavorful formulated solution disposed inside the distal tip. The distal tip is operable to release, eject, or secrete the formulated solution during male ejaculation. The condom-like sheath is shaped to elastically conform to the elongated shape of a male genital member. The sheath has an open proximal end for receiving the male genital member and a distal end that has a distal tip that is selectively closed. The distal tip defines a reservoir containing an ingestible flavored solution and is operable to permit the release of a composition of the flavored solution and any seminal fluid that has entered the reservoir.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: October 28, 2014
    Inventor: Linda Levy
  • Publication number: 20140316425
    Abstract: An inorganic-organic hybrid coating applied to a polymer and method for forming same to provide improved hydrophilicity and lubricity to the surface of the polymer. The hydrophilic coating is on the order of one micron thick, as is formed by activating the surface of the polymer, reacting the activated surface of the polymer with a Lewis acid metallic composition, and then quenching the coating in salt solution having a pH>7.2 at a temperature above the glass transition temperature (Tg) of the polymer.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Inventors: Alexei Ossipov, Thomas R. Paul
  • Publication number: 20140316515
    Abstract: In a method for producing a bioactive surface on an endoprosthesis or on the balloon of a balloon catheter, the surface of the endoprosthesis or the surface of the balloon is softened. The surface of the endoprosthesis or of the balloon is moistened with a solution of an active ingredient and the solvent is separated from the active ingredient. The solvent can be a water-miscible solvent.
    Type: Application
    Filed: March 21, 2014
    Publication date: October 23, 2014
    Inventor: Alexander Rübben
  • Publication number: 20140303263
    Abstract: A method of producing a delivery device for delivering a chemical compound includes i) providing an interpenetrating polymer substrate (IP substrate) having a first continuous polymer comprising rubber and a second polymer having hydrogel or a hydrogelable precursor, where the second polymer is interpenetrating in the first polymer; ii) providing the chemical compound and a loading solvent for the chemical compound; and iii) loading the IP substrate with the chemical compound by subjecting the IP substrate to the loading solvent having the chemical compound under conditions where the loading solvent at least partially swells the second polymer. The chemical compound, the second polymer and the loading solvent are selected such that the work of adhesion (Whc) between the second polymer and the chemical compound during at least a part of the loading is at least about 0 J/m2.
    Type: Application
    Filed: November 23, 2012
    Publication date: October 9, 2014
    Inventors: Martin Alm, Søren Langer Steffensen