Fluid Barrier Or Fluid Transporting Product, Other Than Merely Absorbing (e.g., Surgical Glove, Condom, Lined Diaper, Membrane Filter, Iv Tubing, Cannula, Dialysis Membrane, Urinary Catheter) Patents (Class 427/2.3)
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Publication number: 20080247988Abstract: Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages.Type: ApplicationFiled: May 21, 2007Publication date: October 9, 2008Inventors: Roger E. MARCHANT, Tianhong ZHANG, Yongxing QIU, Mark A. RUEGSEGGER
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Publication number: 20080241349Abstract: Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.Type: ApplicationFiled: April 2, 2008Publication date: October 2, 2008Applicant: Ension, Inc.Inventors: Patrick Cahalan, Linda Cahalan, Greg Johnson, Mark Gartner
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Publication number: 20080228023Abstract: The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.Type: ApplicationFiled: October 31, 2007Publication date: September 18, 2008Inventors: Michael L. Jones, Frank R. Louw
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Patent number: 7425345Abstract: An apparatus comprises a dispenser, a coherent energy source and an beam steering system. The dispenser defines a path of a droplet. The beam steering system is coupled to the coherent energy source and is configured to define a beam path of the coherent energy source. The beam path of the coherent energy source is disposable across the dispenser path at an interaction location. The beam steering system and coherent energy source are collectively configured such that at least one of a direction, a velocity and an acceleration of the droplet is modified within the interaction location.Type: GrantFiled: March 2, 2004Date of Patent: September 16, 2008Assignee: Boston Scientific Scimed, Inc.Inventor: Jan Weber
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Publication number: 20080213461Abstract: Coated microneedle devices and methods of making such devices are provided. In one aspect, a method for coating includes providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which comprises at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure. The coating liquid may include a viscosity enhancer and surfactant. Microneedles having heterogeneous coatings, pockets, or both are also provided.Type: ApplicationFiled: June 19, 2006Publication date: September 4, 2008Applicant: GEORGIA TECH RESEARCH CORPORATIONInventors: Harvinder Singh Gill, Mark R. Prausnitz
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Publication number: 20080206442Abstract: A method an apparatus for coating prostheses via contact patterning with an applicator. Applicators can include rollers, tampons, and ribbons. Coating materials include a variety of substances including polymers and therapeutic agents.Type: ApplicationFiled: February 14, 2008Publication date: August 28, 2008Applicant: LabCoat, Ltd.Inventors: Avraham Shekalim, Eyal Teichman
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Patent number: 7407684Abstract: A multi-step method of manufacturing a medical device containing therapeutic agents that results in a lower maximum error in the amount of therapeutic agents actually disposed thereon and that allows for differential drug release kinetics along the length of the medical device.Type: GrantFiled: January 28, 2004Date of Patent: August 5, 2008Assignee: Boston Scientific Scimed, Inc.Inventors: Steven M. Spencer, Jan Weber
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Publication number: 20080171129Abstract: Disclosed herein are methods of coating an implantable device comprising applying a composition to the device in a predetermined pattern. The composition is then set to form a monolith. The composition applied can comprise a biodegradable polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond.Type: ApplicationFiled: August 16, 2007Publication date: July 17, 2008Applicant: Cappella, INC.Inventors: Shrirang Ranade, Ascher Shmulewitz
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Patent number: 7390525Abstract: A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Moreover, in certain embodiments, the polymer-containing layer does not comprise the cross-linking agent at the time the polymer-containing layer is applied over the reactive layer. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.Type: GrantFiled: January 12, 2005Date of Patent: June 24, 2008Assignee: Boston Scientific Scimed, Inc.Inventors: Samuel J. Epstein, Wendy Naimark
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Publication number: 20080113082Abstract: A method for forming air-laid fibrous articles. The method includes the steps of providing a stream of loose air-entrained fibers, providing a core pocket assembly comprising a central foraminous forming surface and an edge foraminous forming surface, applying a first pressure to the central foraminous forming surface, applying a second pressure to the edge foraminous forming surface wherein the second pressure applied to the edge foraminous forming surface differs from the first pressure applied to the central foraminous forming surface, depositing a portion of the stream of loose air-entrained fibers on the central foraminous forming surface, and depositing a portion of the stream of loose air-entrained fibers on the edge foraminous forming surface.Type: ApplicationFiled: November 15, 2006Publication date: May 15, 2008Inventors: Claudio Antonio Matos, Curtis Hunter Van Valkenburgh, Karen Juliana Fegelman
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Patent number: 7371424Abstract: Methods and apparatuses for coating surface of medical devices using coating heads are disclosed. In one embodiment, the invention includes a coating method using a coating head, wherein the coating head comprises at least one outlet orifice from which flows a coating material, to deposit at least one layer of coating material dispelled through the outlet orifice onto the surface of the medical device. In another embodiment, a slide coating head is used to deposit multiple layers of superposed coating materials. These methods are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats.Type: GrantFiled: April 14, 2004Date of Patent: May 13, 2008Assignee: Boston Scientific Scimed, Inc.Inventor: Marlene C. Schwarz
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Patent number: 7335391Abstract: A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure.Type: GrantFiled: December 5, 2003Date of Patent: February 26, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Patent number: 7265192Abstract: The present invention is directed to breathable elastomeric articles. The articles of the present invention may allow the transmission of water vapor while still providing an effective barrier to virus, bacteria, contaminants, bodily fluids, and the like. In general, a breathability additive may be incorporated into the polymer matrix of one or more layers of the elastomeric article to improve the breathability of the layer.Type: GrantFiled: November 30, 2004Date of Patent: September 4, 2007Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Dave A. Soerens, William E. Conley, Loi Vinh Huynh
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Patent number: 7252856Abstract: A process for fabricating a water-swellable porous plastic plug is provided, the process including the steps of: providing a porous substrate having a plurality of passageways therethrough, disposing into the passageways a hydrophilic polymer, irradiating the substrate to induce cross-linking of the hydrophilic polymer, such that the polymer forms a hydrogel coating on the walls of the passageways.Type: GrantFiled: July 23, 2003Date of Patent: August 7, 2007Assignee: Becton, Dickinson and CompanyInventors: Richmond R. Cohen, Preston Keusch
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Patent number: 7238669Abstract: Whole cell phage-display techniques were used to identify several peptides that bound preferentially to a non-typeable strain of Haemophilus influenzae. These peptides were able to inhibit growth of both H. influenzae and Staphylococcal aureus. Thus, methods for treating bacterial infections, alone or in combination with traditional antibiotics, are envisioned.Type: GrantFiled: September 4, 2003Date of Patent: July 3, 2007Assignee: The Curators of the University of MissouriInventors: Sharon L. Bishop-Hurley, Francis J. Schmidt, Arnold L. Smith
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Patent number: 7141108Abstract: The present invention describes a means for fixing skin care ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto the skin by normal triggering mechanisms, which include the action of water or urine or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels while not interfering with the wettabliity of the fabric or paper. Additionally, incompatible/reactive ingredients can be treated onto the same web and are kept as separate particles fixed to the surface until released.Type: GrantFiled: September 8, 2005Date of Patent: November 28, 2006Assignee: National Starch and Chemical Investment Holding Corp.Inventors: James L. Eden, Mark A. Cole, Remo Santacecilia
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Patent number: 7112298Abstract: A medical device, such as a catheter shaft, having an inner lumen defined by a layer of polymer coating, and a method for forming such a medical device. In some embodiments, the method generally includes the steps of applying a polymer coating to an elongated mandrel, and constructing the remainder of the catheter shaft body around the polymer coated mandrel. In some embodiments, the polymer coating layer is made from water dispersible polymer or water soluble polymer.Type: GrantFiled: October 3, 2002Date of Patent: September 26, 2006Assignee: Scimed Life Systems, Inc.Inventors: Greg J. Kampa, Pu Zhou
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Patent number: 7048962Abstract: The present invention is a method and device, which is suitable for use in an operating theater just prior to implantation, for selectively applying a medical coating to an implantable medical device, for example a stent. Disclosed is a device for use with a stent deployed on a catheter balloon. The device is configured to apply a medical coating of a desired thickness to the surface of a stent only. This is done by use of a drop-on-demand inkjet printing system in association with an optical scanning device. The device is further configured so as to, if necessary, apply a plurality of layered coats, each layered coat being of a different coating material, and if appropriate, different thickness. The section of the housing in which the stent is held during the coating procedure is detachable from the housing base. The detachable housing section may be easily cleaned and re-sterilized or simply disposed or simply disposed of.Type: GrantFiled: July 30, 2002Date of Patent: May 23, 2006Assignee: LabCoat, Ltd.Inventors: Avraham Shekalim, Ascher Shmulewitz
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Patent number: 7014913Abstract: A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.Type: GrantFiled: January 15, 2004Date of Patent: March 21, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Patent number: 6979734Abstract: The present invention relates to rubber latex comprising an amount of starch, which rubber latex has a reduced allergen activity as compared to the same rubber latex without starch. In addition, the invention relates to the use of modified starch as donning powder for surgical gloves, wherein the used starch is a granular, low crystalline, preferably a non-crystalline starch.Type: GrantFiled: May 8, 2000Date of Patent: December 27, 2005Assignee: Budev Medical B.V.Inventors: Max Gregor Paping, Johannes Jeekel
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Patent number: 6951463Abstract: The first embodiment of present invention provides a composition, which includes: (a) a photocatalytic titanium oxide or a photocatalytic titanium oxide precursor; (b) at least one selected from the group including: a silicon compound having the following formula (I): wherein X1, X2, X3 and X4 each independently represent an alkoxy group or a halogen atom, a hydrolyzate of the silicon compound (I), a silicone resin, silicone resin precursor and silica; and (c) a liquid medium. Another embodiment of the present invention provides a dental and oralogic composition, that includes a photocatalytic titanium oxide or a photocatalytic titanium oxide precursor. Another embodiment of the present invention provides a dental and oralogic composition, that includes a photocatalytic titanium oxide or a photocatalytic titanium oxide precursor, and a liquid medium.Type: GrantFiled: December 4, 2000Date of Patent: October 4, 2005Assignee: Kuraray Co., Ltd.Inventors: Eiichi Masuhara, Yoshinori Kadoma, Junichi Yamauchi, Koichi Okada, Satoshi Yamaguchi
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Patent number: 6936298Abstract: The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.Type: GrantFiled: April 13, 2001Date of Patent: August 30, 2005Assignee: Emory UniversityInventors: Elliot L. Chaikof, June Feng, Janine M. Orban, Hongbo Liu, Xue-Long Sun
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Patent number: 6926919Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include blends of hydrophilic and hydrophobic polymers. The methods provide for treatment of the coatings to cause enrichment a region close to the outer surface of the coating with the hydrophilic polymers.Type: GrantFiled: February 26, 2003Date of Patent: August 9, 2005Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Stephen D. Pacetti
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Patent number: 6923996Abstract: A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.Type: GrantFiled: May 6, 2003Date of Patent: August 2, 2005Assignee: SciMed Life Systems, Inc.Inventors: Samuel J. Epstein, Wendy Naimark
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Patent number: 6918392Abstract: A condom applicator supports a condom in a substantially unstretched condition until just before use, and then expands the cross-section of the condom.Type: GrantFiled: December 6, 2001Date of Patent: July 19, 2005Inventor: Leon B. Kassman
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Patent number: 6919100Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.Type: GrantFiled: January 22, 2003Date of Patent: July 19, 2005Assignee: Cordis CorporationInventor: Pallassana V. Narayanan
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Patent number: 6913779Abstract: The following description refers to a process for the impregnation of cross-linked polymers with an active ingredient. The process is based on the used of compressed fluids, in particular CO2, with antisolvent effect, and involves the steps of impregnating the polymer with an active ingredient solution, adding a compressed fluid until precipitation of the active ingredient caused by the compressed fluid antisolvent effect, removing the solvent and the compressed fluid. The process allows to obtain accelerated release pharmaceutical formulations that, compared with the formulations already known, contain larger quantities of amorphous or nanocrystalline active ingredient.Type: GrantFiled: March 7, 2001Date of Patent: July 5, 2005Assignee: Eurand International S.p.A.Inventors: Italo Colombo, Paolo Pallado
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Patent number: 6911228Abstract: A process for manufacturing a toilet training article in the form of a toilet training pad containing an astringent agent or source thereof is disclosed. The toilet training pad, which may be an insertable pad or integrated directly into an undergarment, contains an astringent agent or source thereof which does not contact the wearer's skin until urination occurs at which time a tingling or other sensation is felt on the skin. To prevent contact of the astringent agent with the wearer's skin until urination, the astringent agent may be microencapsulated into a dissolvable shell or may be inserted into a microsponge.Type: GrantFiled: June 6, 2003Date of Patent: June 28, 2005Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Richard L. Underhill, Marsha M. Malone, Bernard J. Minerath, III, Beth A. Lange, Duane G. Krzysik, David W. Koenig
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Patent number: 6908622Abstract: The inventors have found that both the drug dose and drug release profiles are significant factors for the safety and efficacy of drug coated stents. The inventors have identified optimum dosing and release kinetics for drug coated stents. In particular, the inventors have determined dosing and release kinetics that permit the delivery of the lowest effective drug dosage, thus enhancing patient safety and minimizing any side effects from the drug.Type: GrantFiled: September 24, 2002Date of Patent: June 21, 2005Assignee: Boston Scientific SciMed, Inc.Inventors: James J. Barry, Kalpana R. Kamath
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Patent number: 6890583Abstract: A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: November 21, 2001Date of Patent: May 10, 2005Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Aron B. Anderson, Ralph A. Chappa, Timothy M. Kloke
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Patent number: 6884457Abstract: The present invention provides a method for efficiently and uniformly treating articles with two or more fluids without transferring the articles from one container to another container.Type: GrantFiled: May 22, 2002Date of Patent: April 26, 2005Assignee: Novartis AGInventors: Allen Gilliard, Robert Allen Janssen
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Patent number: 6852353Abstract: The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various other moieties may then be chemically attached to the article surface by reaction of the other moieties with the reactive sites through classical chemical attachment mechanisms.Type: GrantFiled: July 23, 2001Date of Patent: February 8, 2005Assignee: Novartis AGInventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally
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Patent number: 6833153Abstract: The present invention relates to coating a porous, hydrophobic polymer with a hemocompatible coating and to the materials produced thereby. One embodiment of the present invention relates to the coating of expanded poly(tetrafluoroethylene) with one or more complexes of heparin, typically containing heparin in combination with a hydrophobic counter ion. The hemocompatible coating is dissolved in a mixture of solvents in which a first solvent wets the polymer to be coated and the second solvent enhances the solubility of the hemocompatible coating material in the solvent mixture. Typical first solvents wetting hydrophobic polymers include non-polar such as hydrocholorofluorocarbons. Typical second solvents include polar solvents such as organic alcohols and ketones. Azeotropic mixtures of the second solvent in the first solvent are used in some embodiments of the present invention although second solvents may be employed in a range of concentration ranges from less than 0.1% up to saturation.Type: GrantFiled: October 31, 2000Date of Patent: December 21, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Wouter E. Roorda, Niraj Shah, Andrė-Jean Lundkvist
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Patent number: 6821549Abstract: The invention relates to a method of coating a surface of a stent by contacting the stent with a coating solution containing a coating material, inserting a thread through the lumen of the stent, and producing relative motion between the stent and the thread to substantially remove coating material located within the openings of the stent. Eliminating or minimizing coating material located within the openings preserves the functionality of the stent. The method can be used to apply a primer layer, a polymer, either with or without a therapeutic agent, and/or a top layer on the stent.Type: GrantFiled: December 16, 2002Date of Patent: November 23, 2004Assignee: Vascular Concept Holdings LimitedInventor: Swaminathan Jayaraman
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Patent number: 6818063Abstract: A stent mandrel fixture for supporting a stent during the application of a coating substance is provided.Type: GrantFiled: September 24, 2002Date of Patent: November 16, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Cameron Kerrigan
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Publication number: 20040215336Abstract: The present invention provides a system for treating a vascular condition, including a catheter, a stent with a stent framework operably coupled to the catheter, and a drug-polymer coating on the stent framework including at least one plasticizer dispersed within the drug-polymer coating.Type: ApplicationFiled: April 23, 2004Publication date: October 28, 2004Inventors: Kishore Udipi, Peiwen Cheng
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Publication number: 20040213892Abstract: The present invention concerns highly swellable absorption mediums with a reduced caking tendency at high humidity and/or high temperatures, wherein a swellable polymer is coated with a non-ionic, nitrogen-containing surfactant and optionally a Lewis acid and then reacted by heating.Type: ApplicationFiled: April 25, 2003Publication date: October 28, 2004Inventors: Gerd Jonas, Richard Mertens, Mark Frank
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Patent number: 6808738Abstract: The present invention is a method for the modification of the surfaces of polymeric materials with polymer coatings that may be subsequently treated to be lubricious and anti-microbial. The method comprises incubating a photo-initiator-coated polymeric material with an aqueous monomer that is capable of free radical polymerization and exposing the incubating polymeric material to UV light creating a modified surface on said polymeric material. The method may additionally comprise adding a silver component to the modified surface. The silver component may be provided as a silver salt coating or a silver salt contained within a hydrogel bonded to the acrylate modified polymeric material surface.Type: GrantFiled: February 27, 2002Date of Patent: October 26, 2004Assignee: Uroteq Inc.Inventors: Valerio DiTizio, Frank DiCosmo
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Patent number: 6803069Abstract: Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. The polymer bound bio-active agents can include anti-thrombogenic agents, antibiotics, antibacterial agents and antiviral agents. Methods of preparing same are also provided.Type: GrantFiled: June 20, 2001Date of Patent: October 12, 2004Assignee: SciMed Life Systems, Inc.Inventors: Birendra K. Patnaik, Horng-Ban Lin, David J. Lentz, Richard J. Zdrahala
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Patent number: 6797311Abstract: A process for impregnating a porous material with a cross-linkable composition is disclosed. The degree of impregnation and placement of the cross-linkable composition within the pores of the porous material can be controlled very precisely through the use of a pressure differential. The pressure differential is effected through a nonreactive gas, a vacuum, or a combination thereof. Medical devices produced using such a method are also disclosed.Type: GrantFiled: February 6, 2003Date of Patent: September 28, 2004Assignee: SciMed Life Systems, Inc.Inventors: Gary L. Loomis, Bruce Parsons
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Patent number: 6793960Abstract: A medical device comprising a substrate having a plasma polymerized functionally bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.Type: GrantFiled: December 3, 2001Date of Patent: September 21, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Murthy Simhambhatla, Charles D. Claude
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Patent number: 6787179Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.Type: GrantFiled: June 29, 2001Date of Patent: September 7, 2004Assignee: Ethicon, Inc.Inventors: Debra A. Timm, Henry K. Hui, Mark B. Roller, Mora C. Melican, Syed Hossainy
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Patent number: 6780424Abstract: A drug delivery system is provided including a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one drug is incorporated into the drug-enriched phase. The system can be used, for example, on implantable medical devices such as stents.Type: GrantFiled: March 30, 2001Date of Patent: August 24, 2004Inventor: Charles David Claude
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Patent number: 6780786Abstract: A membrane structure comprising a silicon film having a grain structure including grains defining pores therebetween.Type: GrantFiled: November 26, 2001Date of Patent: August 24, 2004Assignee: The Regents of the University of CaliforniaInventor: George M. Dougherty
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Patent number: 6764710Abstract: A method of determining whether a substrate has been subjected to an energy source. In one embodiment, the method includes the steps of providing a polymeric surface, providing a light emitting material having a specified emission spectrum that changes upon exposure to an energy source on the surface or embedded in said substrate and applying said energy source to said surface with said light emitting material. This method can be particularly useful for detecting the bond quality in medical devices.Type: GrantFiled: July 18, 2001Date of Patent: July 20, 2004Assignee: Scimed Life Systems, Inc.Inventors: Kenneth M. Merdan, Dachuan Yang, Lixiao Wang
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Patent number: 6764709Abstract: This invention relates to a method for manufacturing an implantable medical device, having a surface covered with a coating that can include a desired amount of a biologically active material, using an ultraviolet (UV) laser. The invention also pertains to a method for manufacturing an implantable medical device having a surface covered with a coating having more than one layer wherein a desired portion of the top layer is ablated with an ultraviolet (UV) laser. Also, the invention relates to a method for measuring a thickness of a coating applied to an implantable medical device. Furthermore, the invention is directed to a method for manufacturing an implantable medical device having a surface covered with a coating free of webbing or cracking.Type: GrantFiled: November 8, 2001Date of Patent: July 20, 2004Assignee: SciMed Life Systems, Inc.Inventor: Aiden Flanagan
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Patent number: 6759473Abstract: By coating a dip-formed article with a coating agent comprising a polymer latex dispersion-stabilized with a water-soluble high-molecular-weight compound containing an alcoholic hydroxyl group, a coated article having excellent donning and putting off properties and anti-blocking property, and exhibiting greatly reduced fine particles-releasability is obtained.Type: GrantFiled: May 20, 2002Date of Patent: July 6, 2004Assignee: Zeon CorporationInventors: Misao Nakamura, Toshihiro Inoue
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Patent number: 6753071Abstract: A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.Type: GrantFiled: September 27, 2001Date of Patent: June 22, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Patent number: 6743462Abstract: A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. An apparatus is also provided for coating the devices. The apparatus comprises a chamber for housing the device wherein the pressure of the chamber can be adjusted during the coating process.Type: GrantFiled: May 31, 2001Date of Patent: June 1, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Publication number: 20040091520Abstract: A disposable examination glove is made by forming a disposable glove from a flexible material; coating the interior surface of the glove with a liquid carrier, Aloe Vera, and at least one alpha hydroxy acid; and removing liquid carrier from the coating to form a substantially dry coating of Aloe Vera and the at least one alpha hydroxy acid on the interior surface of the glove. The dry coating is bonded to the interior surface of the glove so that the coating contacts the hand of a person wearing the glove.Type: ApplicationFiled: November 5, 2003Publication date: May 13, 2004Inventor: Samuel Amdur