Abstract: The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte.

Abstract: The present invention discloses gradients and methods of forming gradients. The gradients can form a component of a molecular machine, such as those disclosed herein. The molecular machines of the present invention can perform a range of tasks including nanoparticle heterostructure assembly, derivatization of a nanoparticle and synthesis of biomolecules, to name just a few applications.

Abstract: A long range, periodically ordered array of discrete nano-features (10), such as nano-islands, nano-particles, nano-wires, non-tubes, nano-pores, nano-composition-variations, and nano-device-components, are fabricated by propagation of a self-assembling array or nucleation and growth of periodically aligned nano-features. The propagation may be induced by a laterally or circularly moving heat source, a stationary heat source arranged at an edge of the material to be patterned (12), or a series of sequentially activated heaters or electrodes. Advantageously, the long-range periodic array of nano-features (10) may be utilized as a nano-mask or nano-implant master pattern for nano-fabrication of other nano-structures.

Abstract: Both a system and method for marking honeycomb structures is provided. The system includes a printing station having a print head moveable relative to a log that prints an identification mark for each structure to be cut from the log; an elevation mechanism that positions the log relative to the printing station, sensors for determining a distance between the print head and log; and a length measuring sensor. A processor is connected to the printing station, elevation mechanism, and length measuring sensor which (a) associates an identification code with the log, (b) generates a separate identification mark for each honeycomb structure to be cut from the log, (c) controls the elevation mechanism to place the log at a desired location relative to the print head of the printing station, and (d) receives length data from the length sensor.

Abstract: The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN and kits for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.

Abstract: Disclosed herein is a method for producing display devices for forming deposited patterns conforming to pixels on a substrate by means of elongated evaporation sources and a deposition mask having regularly arranged apertures, the method including the steps of arranging the deposition mask and the substrate in such a way that the long sides of the apertures and pixels are parallel to the lengthwise direction of the evaporation sources irrespective of the direction in which the display panel regions are arranged within the substrate; and moving the substrate and the deposition mask relative to the evaporation sources, thereby forming the deposited patterns conforming to the pixels on the substrate.

Abstract: Disclosed is a method or device for recognizing a structure, preferably a bead or trace of adhesive material (20), which is to be applied to a substrate (30), with the aid of at least two cameras, more particularly three or more cameras (12, 13, 14). The structure, which is to be applied, is applied to the substrate using an applicator device (11), whereupon the structure, which is applied to the substrate by means of the applicator device, is monitored by the cameras in such a way that the cameras are oriented towards the applied structure with at least one overlapping area, wherein the applied structure, particularly the edges of the trace of adhesive, is determined on a revolving orbit around the applicator device and the revolving orbit is pre-defined in such a way that the applied structure intersects the revolving orbit after it has been applied to the substrate.

Abstract: Embodiments of methods of making superhydrophobic structures comprise depositing a polymer mold onto a silicon surface comprising a plurality of microasperities, removing the polymer mold after the polymer mold has hardened, depositing a liquid epoxy resin into the polymer mold, forming a microstructure with a plurality of microasperities by separating the epoxy resin from the mold after the epoxy resin has solidified, and forming a superhydrophobic structure by depositing a plurality of alkane nanoasperities on the microstructure in the presence of solvent vapor.

Abstract: The invention relates to method of manufacturing a container (1) designed to contain at least one product, preferably a foodstuff, said container (1) having a glass wall (2) made up of an inside face (3) designed to be in contact with said at least one product, and of an outside face (4) that is opposite from said inside face, said method being characterized in that it includes a coating step for covering at least a fraction of said outside face (4) with a coating (8) including at least a silicone and being designed to impart resistance-to-breakage properties to said glass wall (2), said coating step including a dipping step, said method further comprising, prior to the dipping step, a step of pre-heating the container (1), wherein the glass is preferably pre-heated to a temperature lying in the range from 200° C. to 250° C.

Abstract: A method for producing a metallic honeycomb body from metallic layers with channels through which an exhaust gas stream can flow, includes providing the honeycomb body with a coating. Such honeycomb bodies are used in exhaust gas systems of preferably mobile internal combustion engines as catalyst carrier bodies, filters, mixers and/or adsorbers. The coating is provided in a two-stage application and enables the production of exceptionally advantageous coated metallic honeycomb bodies, which are distinguished by a large coating surface and a low flow resistance. At the same time, an exceptionally large surface enlargement is provided in the honeycomb body while using a smaller amount of coating. A honeycomb body is also provided.

Abstract: Ink jet printing on a non-absorbent substrate involves a wet primer having a primer viscosity. The wet primer is applied on the non-absorbent substrate. An ink jet ink having an ink jet viscosity lower than the primer viscosity is jetted over the wet primer while the primer is still wet. The wet primer and ink are simultaneously cured on the substrate.

Abstract: Disclosed herein is a glass sheet substrate and process for making the same with a first wear surface, an obverse, second surface including a thermoset image receiving coating having a complete, unitary sublimated ink image that is viewable with minimal loss of resolution and clarity from the first side through the thickness of the glass sheet substrate.

Abstract: A method of producing a mold having an uneven structure and a mold for an optical element are provided. The method includes forming on a nickel substrate a mixed film using nickel and a material which phase separates from nickel simultaneously, the mixed film including a plurality of cylinders including nickel as a component thereof and a matrix region including the material which phase separates from nickel as a component thereof and surrounding the plurality of cylinders; and removing the matrix portion from the mixed film by etching to give a mold including nickel or a nickel alloy. The uneven structure is disposed in plurality on the substrate, and a pitch of the uneven structure is within a range of 30 nm or more and 500 nm or less and a depth of the uneven structure is within a range of 100 nm or more.

Abstract: A method for reducing non-specific binding in an assay is provided herein. The method includes (a) providing a reaction mixture, which includes or is suspected to include a first component and a second component capable of binding to each other in a specific binding reaction, and (b) adding non-physiological amounts of at least one additive to the reaction mixture before, during or after binding in a sufficient amount to reduce non-specific binding in the reaction mixture. The method further includes (c) monitoring or measuring the presence and/or concentration of at least one of the first and second components after step (b).

Abstract: Systems and methods for discontinuously applying an insulating primer to a carbon fiber reinforced plastic (CFRP) component are disclosed. In one embodiment, a method for mitigating electrical surface discharges from a CFRP component includes first applying an insulating primer to a metallic component. Next, an insulating primer is applied discontinuously to the CFRP component adjacent the metallic component. The discontinuous application of the insulating primer forms a primed portions and unprimed portions. The unprimed portions are configured to enable electrostatic dissipation.

Abstract: Removing of a casting core from a metal casting leaves at least one opening in a surface of the metal. The opening is filled with a sacrificial material. The metal and sacrificial material are machined at the opening. After the machining, a remainder of the sacrificial material is removed.

Abstract: Novel articles and methods to fabricate same with self-assembled nanodots and/or nanorods of a single or multicomponent material within another single or multicomponent material for use in electrical, electronic, magnetic, electromagnetic and electrooptical devices is disclosed. Self-assembled nanodots and/or nanorods are ordered arrays wherein ordering occurs due to strain minimization during growth of the materials. A simple method to accomplish this when depositing in-situ films is also disclosed. Device applications of resulting materials are in areas of superconductivity, photovoltaics, ferroelectrics, magnetoresistance, high density storage, solid state lighting, non-volatile memory, photoluminescence, thermoelectrics and in quantum dot lasers.

Abstract: The invention is a surface coating which will reduce the aldehyde concentration in a room via a aldehyde reactive material contained in the coating. Upon reaction, the aldehyde becomes part of the reactive molecule and, thus, is permanently held within the coating.

Abstract: The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the “systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.

Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

Abstract: The invention provides an ELISA assay for the determination of serum mast cell ?-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the detecting antibody. Luminescent substrate CPSD was used to enhance the assay sensitivity. Also provided are methods for aiding in the diagnosis of irritable bowel syndrome by detecting the serum level of ?-tryptase, histamine and/or prostaglandin E2.

Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.

Abstract: The invention in particular relates to an enamel coating (7) for coating a metal surface (5) of an article (3). For obtaining a surface roughness suitable for adequately bonding further coating layers (8) requiring mechanical bonding interactions, the enamel coating (7) comprises a mixture of a catalytic enamel and at least one of a normal enamel and pyrolytic enamel.

Abstract: The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.

Abstract: Renal injury and inflammation is diagnosed by detecting an elevation in GSK3b level or activity. Inflammation of bodily tissues such as renal tissue is inhibited by administration of GSK3b inhibitory compositions.

Abstract: A process to produce a silane coating includes charging one or several silanes, which are not or only minimally pre-condensed, with a reactant and the thus created coating material is applied onto a substrate and then hardened. Surprisingly it has been shown that, through the reaction involving higher-molecular and only slightly pre-cross-linked silanes with a suitable reactant, a new class of coating materials can be created. The approach is advantageous insofar as restrictions with respect to pot time no longer exist and, in addition, better features of the coating material are obtained, especially a high scratch-resistance.

Abstract: Methods, systems, kits and assays for diagnosing, monitoring or screening for mucopolysaccharidosis (MPS) and methods and systems for assaying test compounds for therapeutic activity are described, whereby MPS marker protein levels are assayed as an indication of MPS.

Abstract: Sample preparation can be a tedious and time consuming task. For example, MALDI imaging of tissue samples can require the tedious process of hand or robotically spotting solutions containing chemical species referred to as “matrix” onto a tissue sample prior its mass spectral analysis. Provided is a process for preparing a sample comprising immersing a solid support that has a surface comprising a first part that is more hydrophilic than a second part into a target compound solution, wherein the target compound is deposited primarily onto the more hydrophilic part; and/or applying and evaporating the target compound solution onto the substrate to produce the pre-coated substrate. A tissue or other sample may then be placed on the substrate for analysis.

Abstract: A method for bonding a substantially transparent substrate within an opening of a structure, including steps of applying to a substantially transparent substrate a primer composition that includes a colorant; applying an adhesive to the structure defining the opening; and installing the substantially transparent substrate within the opening, wherein the resulting installed substrate is substantially free of any ceramic enamel. Also disclosed are assemblies that include a primer composition that includes a colorant and is substantially free of any ceramic enamel.

Abstract: The present invention provides a process for producing a metalized substrate in which a predetermined metal paste composition is applied onto a sintered nitride ceramic substrate (10); the resultant is fired in a heat-resistant container at a predetermined condition; and the substrate (10) and a metal layer (30) are bonded together to each other through a titanium nitride layer (20).

Abstract: The invention relates to a method of using high mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the qualitative and quantitative analysis of the effect of drug candidates on protein complexes such as protein-protein interactions in purified samples or complex biological matrices, as well as to the use of this method for lead compound optimization, drug characterization, drug manufacturing processes, and drug quality control processes, including automated high throughput applications.

Abstract: A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling at least one binding agent to the hydrogel via a second fraction of the binding elements, whereby the protein resistant compound and the at least one binding agent are co-immobilized to the hydrogel. Also the use of the reactive surface in analysis, such as immunogenicity assays, is disclosed.

Abstract: The amount of a paint for forming a porous heat-resistant layer supplied to the outer surface of a gravure roll is adjusted by removing the paint with a blade that is disposed so as to contact the outer surface. A resin blade is used, and the position at which the resin blade contacts the outer surface of the gravure roll is changed as the resin blade wears away. This prevents the amount of the paint for forming the porous heat-resistant layer removed from the outer surface of the gravure roll from changing as the resin blade wears away, so that the excess amount of the paint carried on the outer surface of the gravure roll is removed with good accuracy. An almost constant amount of the paint is thus transferred to an electrode surface from the outer surface of the gravure roll, and a porous heat-resistant layer with an almost uniform thickness is stably formed on an industrial scale.

Abstract: A method of making a drug eluting stent comprises forming a porous stent body surface layer by ion implantation, applying a layer of ceramic particles on the porous layer and compressing the layer of ceramic particles. The layer of ceramic particles can be compressed to successively higher densities. Drugs can be loaded into the layer of ceramic materials at a relatively low density before the layer of ceramic materials is compressed to a higher density to achieve a desired low drug release rate.

Abstract: Mechanical face seal rings having a metallurgically bonded wear-resistant coating on the wear surfaces thereof and methods for forming such coated components is taught herein. The face seal rings, which can be formed of a relatively inexpensive base metal or alloy, have a hard metal alloy slurry disposed on the wear surfaces and then fused to form a metallurgical bond with the iron-based alloy. The wear-resistant coating comprises a fused, metal alloy comprising at least 60% iron, cobalt, nickel, or alloys thereof.

Abstract: There is provided a method of manufacturing an organic EL panel by using a mask that includes a blocking portion blocking incoming particles and a plurality of opening portions through which the incoming particles can pass.

Abstract: A method of applying a dental composition to tooth surfaces is provided. The dental composition, comprising polymerizable resin and fluorescing compound, is applied to a tooth surface and cured so that it hardens. The composition is preferably used as a dental sealant that provides a hard, glossy surface finish over a tooth. Upon irradiating the sealant with ultraviolet light, the sealant exhibits a bright fluorescent glow. The sealant reverts immediately to its natural color when it is no longer exposed to the ultraviolet light.

Abstract: A contact mask for inkjet printing on a solar cell substrate may be generated by creating a printing bitmap of contacts to be printed on the solar cell substrate. The contacts may be located on the solar cell substrate by mapping coordinates of the printing bitmap to coordinates of the solar cell substrate as positioned in the inkjet printer. The location of the contacts on the solar cell substrate may be defined relative to a location on the solar cell substrate, such as relative to center of mass. The contact mask may be printed by the inkjet printer using the printing bitmap and location information of the contacts.

Abstract: A method of glazing a sash is disclosed. The method begins by placing a sash on a glazing table, wherein the sash defines an opening therein and has a glazing leg extending into the opening in the sash. At least two positioner assemblies are actuated, each positioner assembly having a position member defining a distal end. Each position member is selectively slidable between a stored position and an extended position. When the positioner assemblies are actuated, each position member is moved into the extended position such that the distal end of the positioner member contacts the glazing leg of the sash. A viewing element is then inserted into the sash opening and into abutting contact with portions of the positioner members so as to create a gap between an interior surface of the sash and an outer edge of the viewing element. Once the viewing element is positioned, the positioner members are retracted.

Abstract: A method of controlling “rough coating” and “pinhole-uncoated” surface defects on a steel strip coated with a aluminum-zinc-silicon alloy. The alloy has 50-60% wt Al, 37-46% wt Zn and 1.2-2.3% wt Si. The method includes heat treating the steel strip in a heat treatment furnace and thereafter hot-dip coating the strip in a molten bath and thereby forming a coating of the alloy on the steel strip. The method is characterized by controlling the concentration of (i) strontium or (ii) calcium or (iii) strontium and calcium in the molten bath to be at least 2 ppm.

Abstract: In method of forming a dielectric film and a Plasma Display Panel (PDP) using the dielectric film, a paste is coated on a substrate and forms a dielectric film, and a lateral surface of a terminal portion of the dielectric film has a contact angle in a range of 30 to 80° with respect to a surface of the substrate. The PDP preferably includes: a first substrate and a second substrate facing each other and forming a discharge space; a plurality of pairs of sustain electrodes arranged on the first substrate; and a plurality of address electrodes arranged on the second substrate. At least one dielectric film is preferably arranged between the first substrate and the second substrate, and a lateral surface of a terminal portion of the dielectric film preferably has a contact angle in a range of 30 to 80° with respect to a surface of the first substrate.

Abstract: Disclosed is a method for patterning a nanomaterial using solution evaporation. More particularly, the method for patterning a nanomaterial using solution evaporation includes; coating the nanomaterial with a polymer material and uniformly dispersing the coated nanomaterial in a solvent to prepare a solution containing the nanomaterial, and pouring the nanomaterial-containing solution on a substrate, enabling the nanomaterial to be patterned after evaporation of the solvent.

Abstract: A method of masking cooling holes of a turbine component, in particular a turbine blade or vane, for a coating process is provided. The component includes an external surface to be coated, at least one internal cavity having an opening towards the outside of the component, and cooling holes extending from the at least one internal cavity to the external surface. The method comprises the steps of: filling the cooling holes with a masking material and hardening the masking material. The masking material, water, is used to fill in the cooling holes. The hardening is done by freezing the water to water ice. A method of coating an external surface of a turbine component and a device for use in a masking process for masking cooling holes in a turbine component are also provided.

Abstract: Imaged articles and methods for producing imaged articles in which an image has been transferred by dye sublimations techniques to a powder coated substrate are described. The powder coated substrates may include various metals or alloys. The powder coated substrate may include a white powder coating layer and an over cured clear coat layer. The imaged article may be subsequently formed into desired three-dimensional shapes without significant loss in image quality or image degradation.

Abstract: The present invention provides a method for manufacturing a multilayer information recording medium including at least two information recording portions and a resin layer interposed between the information recording portions, both of which are disposed on a signal substrate. The method includes a first process of forming a predetermined information recording portion on one principal surface of the signal substrate and a second process of passing a part of a resin-containing coating, which is supplied on a screen having an application region with a plurality of first pores and a removal region with a plurality of second pores, through the first pores by sliding a squeegee on the screen so as to form a coating layer on the predetermined information recording portion, and curing the resin contained in the coating layer so as to form the resin layer. The first process and the second process are carried out respectively a predetermined number of times.

Abstract: A method and system of coating an implantable device, such as a stent, are provided.

Abstract: A process for imparting a simulated patina appearance to a copper substrate including selecting a colorant having the desired initial patina color tone and producing a noncontinuous layer of the colorant on a surface of the copper substrate to provide the appearance of patination of the desired tone via interspersed spots of the colorant. The remaining portion of the substrate is exposed for natural patination.

Abstract: The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate, the substrate having at least one dam portion.

Abstract: The invention provides a method for producing a modified surface (5) comprising: patterning a surface (7) by forming thereon a porous molecular network (9) defined by non-covalent interactions between constituent molecules; and depositing in said porous network (9) and on said patterned surface (11) molecules (13) so as to form a self-assembled monolayer (15), wherein both said patterning and said depositing are effected by contact with liquids.

Abstract: A cationically polymerizable composite coating composition comprising: a) a condensation product of at least one hydrolyzable silane having a fluorine-containing group, b) at least one cationically polymerizable organic resin, and c) a cationic initiator, provides, upon curing, substrates with an alkali-resistant, liquid-repellent coating. The composite coating composition may be used in pattern forming methods.