Preparing Compound Containing At Least Three Carbocyclic Rings Patents (Class 435/127)
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Publication number: 20100031452Abstract: The present invention relates to azo dyes, in particular azo dyes of Formula (I) or (II), a tautomer, a quaternary amine, or a salt thereof, wherein R1, R2a, R2b, R3, R4, R5, R3, R7, R8, R9, R10, R11 have the same meaning as in the claims. The present invention also relates to processes for preparing said compounds, compositions containing them and their use as dyes.Type: ApplicationFiled: July 7, 2009Publication date: February 11, 2010Applicants: Universite Catholique de Louvain, Wetlands Incubator sprlInventors: Estelle Enaud, Christian-Marie Bols, Ana Casas Infantes, Sylvie Groslambert, Christoph Hercher, Gilles Iacazio, Jutta Ismene Jager, Jacqueline Marchand-Brynaert, Rezzan Karaaslan, Mehmet Emre Sener, Thierry Tron, Sophie Vanhulle
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Publication number: 20090186390Abstract: A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein the method comprises inactivation of at least one gene involved in methylhexahydroindanedione propionate degradation. Strains with (multiple) inactivated steroid degrading enzyme genes according to the invention can be used in the accumulation of steroid intermediates. Accumulation products are for example 3a?-H-4?(3?-propionic acid)-7a?-methylhexahydro-1,5-indanedione (HIP), 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA), 1,4-androstadiene-3,17-dione (ADD) and 3a?-H-4?(3?-propionic acid)-5?-hydroxy-7a?-methylhexahydro-1-indanone-?-lactone (HIL).Type: ApplicationFiled: August 20, 2008Publication date: July 23, 2009Inventors: Robert van der Geize, Gerda Hessels, Lubbert Dijkhuizen
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Patent number: 7556948Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.Type: GrantFiled: August 7, 2003Date of Patent: July 7, 2009Assignee: Glaxo Group LimitedInventors: Michael John Rees, Keith Graham Robins, Anna Louisa Stefanska, Jan Edward Thirkettle, Michael Sidney Verrall, David Alan Yeandle
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Patent number: 7432102Abstract: An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant to be used for this method. According to the present invention, there is provided a transformant producing substance FF1022 derivatives, which can be obtained by introducing a genes involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid, including a papA gene encoding 4-amino-4-deoxychorismate synthase. which gene comprises the DNA sequence encoding the amino acid sequence of SEQ ID NO: 2; a papB gene encoding 4-amino-4-deoxyclaismate mutase, which gene comprises the DNA sequence encoding the amino acid sequence of SEQ ID NO: 4; and a papC gene encoding 4-amino-4-deoxyprepbenate dehydrogenase, which gene comprises the DNA sequence encoding the amino acid sequence of SEQ ID NO: 6, into a phenylalanine auxotrophic host induced from an organism that produces a substance PF1022.Type: GrantFiled: March 22, 2002Date of Patent: October 7, 2008Assignee: Meiji Seika Kaisha, Ltd.Inventors: Koji Yanai, Naomi Sumida, Manabu Watanabe, Tatsuki Moriya, Takeshi Murakami
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Patent number: 7354747Abstract: Carbohydrate-derived side-chain polyethers that may be synthesized by condensation polymerization of monomers derived from natural occurring carbohydrates. These compounds are protein resistant, biodegradable and may be functionalized at location other that the chain ends. Various devices, apparatus and articles of manufacture may be formed, at least in part, of the compounds of the present invention to achieve desirable protein resistance, biodegradability and/or functionalization.Type: GrantFiled: May 10, 2004Date of Patent: April 8, 2008Assignee: The Regents of the University of CaliforniaInventor: Zhibin Guan
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Patent number: 7335498Abstract: The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same. A protein according to the present invention are concerned with (a), (b) or (c), namely (a) a protein comprising an amino acid sequence selected from the group consisting of the amino acid sequences shown in SEQ ID NOs: 2, 4, and 6; (b) a protein that has at least 50% homology to the protein comprising the amino acid sequence of the sequence described in (a) and having saponin-decomposing activity; or (c) a protein comprising a modified amino acid sequence of the sequence described in (a) that has one or more amino acid residues deleted, substituted, inserted, or added and having saponin-decomposing activity.Type: GrantFiled: August 16, 2006Date of Patent: February 26, 2008Assignee: Meiji Seika Kaisha, Ltd.Inventors: Manabu Watanabe, Naoki Mido, Takayoshi Tamura, Naomi Sumida, Takashi Yaguchi
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Patent number: 7294492Abstract: The present invention is directed to the use of yeasts to produce spiroketal fragrance materials. The preferred yeasts used in the method of the invention are Bensingtonia ciliate and Cryptococcus laurentii.Type: GrantFiled: January 7, 2005Date of Patent: November 13, 2007Inventors: Kwang-Pil Choi, Michael P. McLean, John Lyons Buckley, III, Mark L. Dewis
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Patent number: 7125692Abstract: A process for producing a monomer for resists represented by the following general formula 1: wherein R1 represents hydrogen or an optionally substituted alkyl group; R2, R3 and R4 each independently represent hydrogen or a substituent; and X, Y and Z each independently represent a direct bond or an optionally substituted alkylene group with 1 to 3 chain members, the process comprising carrying out esterification or transesterification in the presence of a biocatalyst.Type: GrantFiled: September 11, 2002Date of Patent: October 24, 2006Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Eiji Satou, Makoto Kaneko, Naoshi Murata
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Patent number: 6872517Abstract: The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a biological sample obtained from the gastrointestinal tract.Type: GrantFiled: May 10, 2001Date of Patent: March 29, 2005Assignee: Lankenau Institute for Medical ResearchInventors: James M. Mullin, James Thornton
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Publication number: 20040053376Abstract: Process for preparing pure phosphatides starting from mixtures of natural phosphatides, or their single components, such as soybean or egg lecithin or animal phospholipids, or from synthetic phosphatides by reacting them both with phospholipase D derived from Streptomyces hachijoense in a completely aqueous medium in the presence of defined substates containing a primary or secondary alcoholic group, and their uses thereof.Type: ApplicationFiled: September 15, 2003Publication date: March 18, 2004Applicant: Fidia Farmaceutici S.p.A.Inventors: Guenter Kirschner, Giampaolo Menon, Susanna Vaccaro
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Patent number: 6589765Abstract: The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the production of the paclitaxel comprises the following procedure: (i) cultivating the Taxus genus plant cells in a medium at ca. 20 to 25° C.; and (ii) when growth of the plant cells has progressed sufficiently, changing the cultivation temperature to ca. 26 to 32° C. to continue the culture. The present invention comprises also the method of increasing the paclitaxel production by inoculating the cells at a high initial concentration and by increasing the saccharide concentration in the medium: According to the present invention, paclitaxel can be mass-produced conveniently and therefore has an industrial application.Type: GrantFiled: February 26, 1999Date of Patent: July 8, 2003Assignee: Samyang Genex CorporationInventors: Ho-Joon Choi, Hyung-Kyoon Choi, Sang-Ic Kim, Jeong-Hwan Yun, Joo-Sun Son, Moon-Seok Chang, Eunsoo Choi, Hong-Rak Kim, Seung-Suh Hong, Hyun-Soo Lee
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Patent number: 6586201Abstract: A method of chromatographic isolation for non-glyceride components (squalenes, carotenes, vitamin E, sterols and/or the like) from a non-glyceride components-comprising compound by the steps of a. introducing the non-glyceride components-comprising compound onto a selective adsorbent to allow an adsorption of the non-glyceride components, and subsequently b. desorbing the non-glyceride components from the adsorbent, wherein the adsorption and/or desorption of the non-glyceride components is carried out under a supercritical fluid environment.Type: GrantFiled: November 2, 2000Date of Patent: July 1, 2003Inventors: Choo Yuen May, Ma Ah Ngan, Yusof Basiron
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Patent number: 6479657Abstract: A process for producing crystal 1-kestose wherein granular crystal 1-kestose in the form of large crystals can be produced at a high yield is disclosed. A highly pure solution of 1-kestose is concentrated to a Brix of 75 or higher; either seed crystals are added, or the solution is vacuum-concentrated to generate microcrystals for use as nuclei; then, a crystal growing step by vacuum-concentration and a microcrystal dissolving step for redissolving microcrystals which have formed in the concentrate are repeated at least twice each. Alternatively, a highly pure solution of 1-kestose is concentrated to a Brix of 80 or higher; either seed crystals are added, or the solution is allowed to initiate crystallization; after crystals are allowed to grow, a cooling step where the temperature is lowered by 5° C. to 20° C. from the previous step and a crystal growing step where the concentrate is maintained at the temperature to allow the crystals to grow are repeated at least twice each.Type: GrantFiled: September 29, 1998Date of Patent: November 12, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Koji Nishizawa, Hitoshi Matsumoto, Hirofumi Nakamura, Takashi Kawakami, Yuko Nakada, Masao Hirayama, Takashi Adachi
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Patent number: 6472169Abstract: A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.Type: GrantFiled: September 30, 2000Date of Patent: October 29, 2002Assignee: Board of Trustees operating Michigan State UniversityInventors: John W. Frost, Karen M. Frost, David R. Knop
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Patent number: 6428989Abstract: The present invention discloses a method for producing a taxane-type diterpene(s) by culturing cells of a taxane-type diterpene-producing plant, comprising one or both of the the following steps (a) and (b) to increase the ratio of those cell clusters suitable in size for diterpene production: (a) at least one operation for removing large cell clusters is conducted with a sieve and/or a filter during preculture of the cells to be supplied to main culture for the production of taxane-type diterpenes or at the time of cell transfer from one preculture to the subsequent preculture; (b) the cells are cultured under strong agitation conditions.Type: GrantFiled: June 24, 1998Date of Patent: August 6, 2002Assignee: Mitsui Chemicals, Inc.Inventors: Yukihito Yukimune, Kouichi Matsubara, Yasuhiro Hara
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Patent number: 6046041Abstract: A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana or Pseudopterogorgia elisabethae has been developed which efficiently transforms a variety of precursor molecules, e.g., sterols, to their corresponding metabolites, e.g., 9(11)-secosteroid in high yield. NAD, NADP, and glutamate dehydrogenase can be used as additives in this enzymatic conversion. In addition to naturally-occurring metabolites, novel secosteroids have been prepared.Type: GrantFiled: July 25, 1997Date of Patent: April 4, 2000Inventor: Russell G. Kerr
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Patent number: 5928910Abstract: The present invention relates to a compound represented by the general formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom, or ##STR2## and R.sub.2 is a hydrogen atom or OH and R.sub.2 is a hydrogen atom or a lower alkanoyl group, and an antifungal agent containing it as an active ingredient.Type: GrantFiled: May 19, 1998Date of Patent: July 27, 1999Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Hiroshi Kushida, Shigeru Nakajima, Shigeru Uchiyama, Masao Nagashima, Katsuhisa Kojiri, Kenji Kawamura, Hiroyuki Suda
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Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex
Patent number: 5925550Abstract: The present invention relates to a method for selectively enhancing the production of factors A.sub.2 and/or A.sub.3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A/16686 producing culture during fermentation.Type: GrantFiled: December 18, 1997Date of Patent: July 20, 1999Assignee: Biosearch Italia S.p.A.Inventors: Giancarlo Lancini, Angelo Borghi, Piero Antonini -
Patent number: 5861277Abstract: Disclosed are methods of increasing exogenous protein expression in a cell or a transgenic plant. Constructs, i.e., vectors, DNA fusions and polynucleotides, for use in conjunction with the methods to cause increased exogenous protein expression are also disclosed. These constructs generally include intron 1 and/or intron 2 of the PAT1 gene. Additionally disclosed are cells, including recombinant cells, and plant lines transformed with the described constructs. In particular, a cultivated, transgenic food plant, the genome of which has been augmented through the genomic introduction of a preselected exogenous protein gene not found in the genome of non-transformed parentage of the plant is described. Also described are seed, progeny and cells of the described transgenic food plant.Type: GrantFiled: October 2, 1996Date of Patent: January 19, 1999Assignee: Boyce Thompson Institute for Plant Research, Inc.Inventors: Alan B. Rose, Robert L. Last
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Patent number: 5861293Abstract: This invention relates to glycosyltransferase, genes encoding glycosyltransferase, recombinant vectors having such a gene, host cells transformed with such a recombinant vector, and uses thereof. This invention makes it possible to glycosylate indolopyrrolocarbazole derivatives conveniently and economically.Type: GrantFiled: December 12, 1996Date of Patent: January 19, 1999Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Katsuhisa Kojiri, Hajime Suzuki, Hisao Kondo, Hiroyuki Suda
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Patent number: 5840682Abstract: The invention is directed to a compound of formula ##STR1## in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH.sub.2 --COOH radical, R.sub.1 represents a hydrogen atom, an adamantylacetyl, adamantylcarbonyl, norbornylacetyl, norbornylphenoxycarbonyl, benzoyl, nicotinoyl, 4-phenylbenzoyl, 4-tert-butylbenzoyl or 2-pyrrolidinecarbonyl radical or a protective group for an amine functional group, R.sub.2 represents an Arg or Lys residue, R.sub.3 represents an Arg or Lys residue, R.sub.4 represents a Pro residue, m, n and p, which are the identical or different, represent a number equal to 0 or 1, R.sub.5 and R.sub.6 are identical and represent a hydroxyl or methoxy radical and R.sub.7 represents a hydrogen, chlorine, bromine or iodine atom or a nitro radical, or the compound wherein one or a number of peptide bonds between two amino acid residues are replaced by --CH.sub.2 --NH bonds or the peptide bond between the R.sub.2 and R.sub.3 amino acid residues is replaced by a CH.dbd.Type: GrantFiled: November 19, 1996Date of Patent: November 24, 1998Assignee: Rhone-Poulenc Rorer S.A.Inventors: Francois-Frederic Clerc, Marie-Christine Dubroeucq, Gerard Helynck, Jean Leboul, Jean-Paul Martin
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Patent number: 5801023Abstract: This invention provides compounds of the following chemical formula or their pharmaceutically-acceptable salts: ##STR1## wherein R is hydrogen or chloro. Also, the present invention provides a process for the production of the compound of formula I, which comprises cultivating a microorganism having the identifying characteristics of Aspergillus fischeri var. thermomutatis ATCC 18618 or the like, and then isolating the compound of formula I from the fermentation broth. The pyrrolobenzoxazine compounds of formula I of this invention have broad antiparasitic activity, and thus are useful as antiparasitic agents, especially as anthelmintics.Type: GrantFiled: November 29, 1996Date of Patent: September 1, 1998Assignee: Pfizer Inc.Inventors: Yasuhiro Kojima, Yuji Yamauchi, Nakao Kojima, Bernard F. Bishop
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Patent number: 5773264Abstract: A process for the production of 17.alpha.-hydroxy-3-methoxy-8,14-seco-1,3,5 (10),9(11)estratetraen-14-one by fermentation of 3-methoxy-8,14-seco-1,3,5(10),9(11) -estratetraene-14,17-dione with a live culture of Kloeckera magna is described, which is characterized in that the substrate is reacted in the form of a solventless aqueous suspension with an average grain size of 0.2 to 5 .mu.m.Type: GrantFiled: September 26, 1994Date of Patent: June 30, 1998Assignee: Schering AktiengesellschaftInventors: Alfred Weber, Mario Kennecke, Hans-Jorg Vidic
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Patent number: 5763234Abstract: A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana has been developed which efficiently transforms a variety of sterols to their 9(11)-secosteroid derivative in high yield. NAD, NADP, and glutamate dehydrogenase are key additives in this enzymatic conversion. In addition to naturally-occurring metabolites, novel secosteroids have been prepared.Type: GrantFiled: July 25, 1996Date of Patent: June 9, 1998Assignee: Florida Atlantic UniversityInventor: Russell G. Kerr
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Patent number: 5747303Abstract: The invention is directed to a novel compound of formula ##STR1## in which R is a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH.sub.2 --COOH radical, R' and R" are identical and are each a hydroxy or methoxy radical and R'" represents a hydrogen, bromine, chlorine or iodine atom or a nitro radical. The invention is also directed to the salts of said compounds and their use.Type: GrantFiled: November 19, 1996Date of Patent: May 5, 1998Assignee: Rhone-Poulenc Rorer S.A.Inventors: Jean-Jacques Debernard, Catherine Dubertret, Gerard Helynck, Jean Leboul, Jean-Paul Martin
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Patent number: 5702929Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: October 21, 1996Date of Patent: December 30, 1997Assignee: Merck & Co., Inc.Inventors: Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Stanley L. Streicher, Deborah L. Zink, John R. Thompson, Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente
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Patent number: 5593870Abstract: The present invention is directed to a process for producing frenolicin B. The process comprises fermenting a broth so as to produce frenolicin, said broth having a microorganism capable of producing frenolicin. The frenolicin is then converted in the broth under anaerobic conditions to deoxyfrenolicin. The deoxyfrenolicin is converted to frenolicin B.Type: GrantFiled: September 14, 1994Date of Patent: January 14, 1997Assignee: Hoffmann-La Roche Inc.Inventors: David E. Block, Theron E. Hermann, Jih-Han Hsieh, Nikhil S. Mehta, Vishva R. Rai
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Patent number: 5563054Abstract: The present invention provides a biotransformation process for preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or a .beta.-glucuronide group of the formula ##STR2## provided at least one of R.sub.1 and R.sub.2 is a .beta.-glucuronide group.Type: GrantFiled: March 31, 1995Date of Patent: October 8, 1996Assignee: Eli Lilly and CompanyInventors: Barbara S. Briggs, Milton J. Zmijewski, Jr.
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Patent number: 5492819Abstract: There is disclosed a process for the recovery of an insoluble fermentation product from a solid phase cell mass, the process comprising treating the fermentation broth to solubilize the cell mass and separating by known methods the liquid phase from the insoluble (product-containing) phase. The solubilization of the cell mass may be carried out by one or mere treatments with an alkali or acid compound or by enzymatic treatment of the cell mass to lyze the cells.Type: GrantFiled: September 23, 1993Date of Patent: February 20, 1996Assignee: Genencor International, Inc.Inventors: Richard P. Crowley, Jeffrey M. Gerstner
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Patent number: 5474923Abstract: A method for introducing hydroxyl groups into vitamin D compound at the 1.alpha.- and/or 25-positions in the presence of a cyclodextrin compound by the use of a reaction mixture containing a microorganism being capable of hydroxylating vitamin D compound or a enzyme produced from the microorganism, is disclosed.Type: GrantFiled: June 7, 1991Date of Patent: December 12, 1995Assignee: Mercian CorporationInventors: Koji Takeda, Kiyoshi Kimura, Kazuhiko Okamura, Rokuro Okamoto, Joji Sasaki, Takashi Adachi, Sadafumi Omura
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Patent number: 5444087Abstract: Manumycin C, Manumycin D and Manumycin E, obtainable by cultivation of a strain of Streptomyces sp. A.T.C.C. No. 55484, oxidized derivatives thereof and salts and prodrugs of these compounds. The novel compounds have antibacterial and antitumor activity.Type: GrantFiled: October 19, 1993Date of Patent: August 22, 1995Assignee: Bristol-Myers Squibb CompanyInventors: Pramathesh S. Patel, Yue-Zhong Shu
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Patent number: 5431896Abstract: Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.Type: GrantFiled: July 30, 1992Date of Patent: July 11, 1995Assignee: Merck & Co., Inc.Inventors: Louis Kaplan, Robert P. Borris, Kevin M. Byrne, Linda S. Wicker, Deborah L. Zink
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Patent number: 5407816Abstract: This invention is directed to methods for the enhanced production and recovery of taxol and taxanes by cell cultures of Taxus species.Type: GrantFiled: April 24, 1992Date of Patent: April 18, 1995Assignee: Phyton Catalytic, Inc.Inventors: Venkataraman Bringi, Prakash G. Kadkade, Christopher L. Prince, Barry F. Schubmehl, Eugene J. Kane, Braden Roach
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Patent number: 5403728Abstract: The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.Type: GrantFiled: June 17, 1993Date of Patent: April 4, 1995Assignee: BIOGAL Gyogyszergyar RTInventors: Antonia Jekkel, Eva Ilkoy, Istvan M. Szabo, Gabor Ambrus, Attila Andor, Ilona Varga, Imre Moravcsik, Istvan Szabo, Janos Erdei, Kalman Polya, Andras Kiss, Laszlo Cseke, Karoly Nagy, Mihaly Kaszas, Lajos Kiss, Istvan Magyi, Edit Halasz, Gyorgy Santha
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Patent number: 5338845Abstract: A novel Aspergillus species, cyclic dimeric dipeptide derivatives which are biosynthetic products thereof and are useful as Substance P antagonists and therefore as analgesic and/or antiinflammatory agents, and a process for preparation of the biosynthetic products are disclosed.Type: GrantFiled: December 2, 1992Date of Patent: August 16, 1994Assignee: Sterling Winthrop Inc.Inventors: Colin J. Barrow, James E. Brownell, David R. Houck, Anderson C. Hong, Janet L. Popp, David M. Sedlock
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Patent number: 5316939Abstract: A biological pure culture of a microorganism belonging to the genus Rhodococcus and being capable of oxidizing the allyl position of .alpha.-cedrene, a process for producing sec-cedrenol comprising contacting a microorganism belonging to the genus Rhodococcus with .alpha.-cedrene, and a process for producing cedrenone comprising oxidizing sec-cedrenol produced by a microorganism belonging to the genus Rhodococcus, are disclosed. According to the process of the present invention, sec-cedrenol can be produced efficiently within a short period of time and with high purity. In addition, the process of the present invention can produce cedrenone with a high yield in a large quantity within a short period of time.Type: GrantFiled: April 1, 1992Date of Patent: May 31, 1994Assignee: Kao CorporationInventors: Hirofumi Takigawa, Hiromi Kubota, Susumu Ito
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Patent number: 5302522Abstract: A biological pure culture of a microorganism belonging to the genus Rhodococcus and being capable of oxidizing the allyl position of .alpha.-cedrene, a process for producing sec-cedrenol comprising contacting a microorganism belonging to the genus Rhodococcus with .alpha.-cedrene, and a process for producing cedrenone comprising oxidizing sec-cedrenol produced by a microorganism belonging to the genus Rhodococcus, are disclosed. According to the process of the present invention, sec-cedrenol can be produced efficiently within a short period of time and with high purity. In addition, the process of the present invention can produce cedrenone with a high yield in a large quantity within a short period of time.Type: GrantFiled: August 26, 1993Date of Patent: April 12, 1994Assignee: Kao CorporationInventors: Hirofumi Takigawa, Hiromi Kubota, Susumu Ito, Yoshiaki Fujikura, Shigeyoshi Tanaka
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Patent number: 5290698Abstract: A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism Streptoverticillium FERM P-10489, capable of producing the novel substance are disclosed.Type: GrantFiled: December 4, 1992Date of Patent: March 1, 1994Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Hiroyuki Suda, Katuhisa Kojiri, Akira Okura, Kenji Kawamura, Masanori Okanishi
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Patent number: 5248601Abstract: A biotechnological process for preparing L(-)-carnitine chloride, having the formula ##STR1## comprising: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula ##STR2## wherein R is an alkyl group having from 1 to 10 carbons or a benzyl group, with an enzyme capable of selectively hydrolyzing enantiomer S(-);(b) separating the enantiomer S(-) from non-reacted ester which is present in predominantly the R(+) form;(c) reacting the non-reacted ester obtained in step (b) with an enzyme capable of quantitatively hydrolyzing the R(+) form to obtain thereby a salt of 3,4-epoxybutyric acid in the R(+) form having the formula ##STR3## wherein X is Na, K, or Li; (d) reacting the salt obtained in step (c) with a molar excess of trimethylamine; and(e) treating the reaction product of step (d) with HCl to remove excess trimethylamine and to obtain thereby the L(-)-carnitine chloride of formula (I).Type: GrantFiled: October 9, 1990Date of Patent: September 28, 1993Inventors: Franco Francalanci, Marco Ricci, Pietro Cesti, Carlo Venturello
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Patent number: 5236929Abstract: Disclosed is UCA1064-B, a compound represented by formula (I): ##STR1## and having an antibacterial, antifungal and anti-tumor activity. UCA1064-B is produced by culturing a microorganism belonging to the genus Wallemia.Type: GrantFiled: March 10, 1992Date of Patent: August 17, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tatsuya Tamaoki, Isami Takahashi, Katsuhiko Ando, Mayumi Yoshida, Toshiaki Iwazaki
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Patent number: 5217885Abstract: A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism capable of producing the novel substance are disclosed.Type: GrantFiled: January 21, 1992Date of Patent: June 8, 1993Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Hiroyuki Suda, Katuhisa Kojiri, Akira Okura, Kenji Kawamura, Masanori Okanishi
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Patent number: 5212078Abstract: Described is a microbiological method for producing the lactone, sclareolide having the structure: ##STR1## and a diol having the chemical structure: ##STR2## using a sclareol derivative having one of the structures: ##STR3## wherein a combination of two or more of the compounds as a substrate and using one of the microorganisms:Cryptococcus albidus, ATCC 20918Bensingtonia ciliata, ATCC 20919Cryptococcus laurentii, ATCC 20920 orCryptococcus albidus, ATCC 20921.Type: GrantFiled: April 25, 1990Date of Patent: May 18, 1993Assignee: International Flavors and Fragrances Inc.Inventors: Mohamad I. Farbood, James A. Morris, Arthur E. Downey
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Patent number: 5079376Abstract: Disclosed is novel compound UCT-1003 represented by the following formula: ##STR1## and having anti-tumor activity. UCT-1003 is produced by culturing a microorganism belonging to the genus Paecilomyces.Type: GrantFiled: January 23, 1990Date of Patent: January 7, 1992Assignee: Kyowa Hakko Kogyo, Ltd.Inventors: Hirofumi Nakano, Yoshinori Yamashita, Katsuhiko Ando, Yutaka Saito, Keiichi Takahashi, Hiroe Ohno
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Patent number: 5066817Abstract: Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.Type: GrantFiled: April 30, 1990Date of Patent: November 19, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hirofumi Nakano, Mitsunobu Hara, Tsuyoshi Mokudai, Isao Kawamoto, Mayumi Yoshida, Eiji Kobayashi
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Patent number: 5049496Abstract: A. parasiticus is employed to hydroxylate biphenyls or terphenyls. The hydroxylation reaction is enhanced by gradually adding a carbon source to the culture medium-reaction medium, preferably in an amount to maintain the ammonium level below 300 ppm. during the bioconversion phase. Employment of a mutant strain of A. parasiticus which was isolated following ultraviolet light mutagenesis to reduce its tendency to produce aflatoxins is preferred.Type: GrantFiled: December 24, 1990Date of Patent: September 17, 1991Assignee: General Electric CompanyInventors: David P. Mobley, David K. Dietrich
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Patent number: 5026642Abstract: In a process for the reduction of ketones, the keto compounds are enantioselectively reduced to give secondary alcohols by means of microorganisms. Keto compounds of the formulaR.sup.3 NH--CHR.sup.1 --CO--CH.sub.2 --COOR.sup.2in which R.sup.1, R.sup.2 and R.sup.3 have the meanings defined herein are used as starting compounds.Type: GrantFiled: July 22, 1988Date of Patent: June 25, 1991Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Eckart Radunz, Harry Schwartz, Martin Heinrich
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Patent number: 4992570Abstract: UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.Type: GrantFiled: March 24, 1988Date of Patent: February 12, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hirofumi Nakano, Eiji Kobayashi, Isami Takahashi, Katsuhiko Ando, Mayumi Yoshida, Shiro Akinaga, Takao Iida
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Patent number: 4970163Abstract: Described is a microbilogical method for producing the lactone, sclareolide and a diol having the chemical structure: ##STR1## using sclareol having the structure: ##STR2## as a substrate and using one of the microorganisms: Cryptococcus albidus (saito [skinner var. albidus]), ATCC 20918Bensingtonia ciliata, ATCC 20919Cryptococcus laurentii, ATCC 20920Cryptococcus albidus, ATCC 20921.Type: GrantFiled: August 28, 1989Date of Patent: November 13, 1990Assignee: International Flavors & Fragrances Inc.Inventors: Mohamad I. Farbood, James A. Morris, Arthur E. Downey
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Patent number: 4892821Abstract: A method for introducing hydroxyl groups into vitamin D compounds at 1.alpha.- and/or 25-positions by use of a solution containing the mycelium of Actinomycetales being capable of hydroxylating vitamin D compound or the enzyme produced from the mycelium, is disclosed.Type: GrantFiled: July 5, 1988Date of Patent: January 9, 1990Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Sadafumi Omura, Joji Sasaki, Akiko Mikami, Kazutoshi Mizoue
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Patent number: RE37206Abstract: This invention relates to glycosyltransferase, genes encoding glycosyltransferase, recombinant vectors having such a gene, host cells transformed with such a recombinant vector, and uses thereof. This invention makes it possible to glycosylate indolopyrrolocarbazole derivatives conveniently and economically.Type: GrantFiled: June 22, 1999Date of Patent: June 5, 2001Assignee: Banyu Pharmaceutical co, LtdInventors: Katsuhisa Kojiri, Hajime Suzuki, Hisao Kondo, Hiroyuki Suda