Micro-organism, Tissue Cell Culture Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition Patents (Class 435/41)
  • Patent number: 12006514
    Abstract: The present invention relates to a method for the isolation of subpopulations of cardiac progenitor cells from a heart tissue sample, the population thus obtained and the related uses in the medical field for the cell therapy or cardiac cell and/or tissue transplantation field.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 11, 2024
    Assignee: OLOKER THERAPEUTICS S.R.L.
    Inventors: Giulio Pompilio, Elisa Gambini, Gabriella Spaltro
  • Patent number: 11959063
    Abstract: A system and a method is disclosed for adjusting and/or optimizing a fermentation process performed in one U-loop fermenter, the system including a processor and database for repetitively providing a test value of a fermenter parameter and for repetitively entering the test value of the parameter in the database; wherein the database stores multiple test value entries at various points in time and also stores multiple control value entries at various points in time, wherein the processor performs a mathematical analysis of the test value for providing a calculated test value, and/or the control value for providing at least one calculated control value; and selects, on the basis of the calculated test value and/or on the calculated control value, an adjustment to be introduced into at least one other U-loop fermenter to benefit from the change made in the one U-loop fermenter.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 16, 2024
    Assignee: UNIBIO A/S
    Inventors: Ib Christensen, Leander Petersen, Andre Kofoed Drejer, John Bagterp Jorgensen, Sten Bay Jorgensen, Jorgen K. H. Knudsen
  • Patent number: 11925118
    Abstract: A method of inactivating harmful microorganisms of a filtration medium including pathogenic bacteria and viruses is disclosed which includes placing a predetermined quantity of a hybridized fluorescent silk on to a filtration medium, applying light for a predetermined amount of time to the placed quantity of the hybridized fluorescent silk, and passing a fluid through the medium, wherein the fluid is one of substantially air or substantially water, wherein the hybridized fluorescent silk is one of KillerRed, SuperNova, KillerOrange, Dronpa, TurboGFP, mCherry, or any combination thereof.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Jung Woo Leem, Seung Ho Choi, Young L. Kim
  • Patent number: 11925117
    Abstract: A method of disinfection of a surface of a subject of harmful microorganisms including pathogenic bacteria and viruses upon visible light irradiation using a hybridized fluorescent silk is provided. The method includes placing a predetermined quantity of the hybridized fluorescent silk i) directly on to a skin surface of a subject; or ii) on a medium and then placing the medium on the skin surface of the subject. The method further includes applying light in the visible spectrum for a predetermined amount of time to the placed quantity of hybridized fluorescent silk, wherein the hybridized fluorescent silk is one of KillerRed, SuperNova, KillerOrange, Dronpa, TurboGFP, mCherry, or any combination thereof.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: March 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Jung Woo Leem, Seung Ho Choi, Young L. Kim
  • Patent number: 11781149
    Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: October 10, 2023
    Assignee: Trustees of Boston University
    Inventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
  • Patent number: 11697829
    Abstract: The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: July 11, 2023
    Assignee: Ginkgo Bioworks, Inc.
    Inventors: Curt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
  • Patent number: 11684564
    Abstract: The present disclosure relates to a Taraxacum Coreanum phytoplacenta cell culture extract that has moisturizing and soothing effects for extremely dry skin such as atopic dermatitis, and skin barrier strengthening effect. The Taraxacum Coreanum phytoplacenta cell culture or an extract thereof according to the present disclosure is non-toxic to skin cells, and has an efficacy of moisturizing, anti-aging, strengthening the skin barrier, improving wrinkles, soothing the skin, protecting the skin from UV rays, and protecting the skin from blue light, etc.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: June 27, 2023
    Assignee: TALITHAKOUM CO., LTD.
    Inventor: Moon Sun Chai
  • Patent number: 11649473
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: May 16, 2023
    Assignee: DSM Nutritional Products AG
    Inventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
  • Patent number: 11547662
    Abstract: The present invention relates to the treatment of autoimmune and allergic diseases by oromucosal administration of a formulation consisting of an optimized combination of antigen, tolerizing agent and mucoadhesive carrier for each immune disease indication.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: January 10, 2023
    Assignee: Allero Therapeutics B.V.
    Inventors: Emil Richard George Pot, Cornelis Johannes Leenhouts, Poul Sörensen
  • Patent number: 11390872
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns re-combinant polypeptides and uses thereof.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 19, 2022
    Assignee: Genentech, Inc.
    Inventors: Dorothea Reilly, Yizhou Zhou
  • Patent number: 11377597
    Abstract: A method for transforming organic waste into carbon using sequential physical and biological degradation, including fermentation, drying under vacuum and elevated temperature followed by heating to a temperature of between 300° C. and 500° C. to promote carbonization and production of charcoal.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: July 5, 2022
    Assignee: SERENDIPITY TECHNOLOGIES LLC
    Inventor: Amen Dhyllon
  • Patent number: 11339350
    Abstract: A process for producing free fatty acids from oil containing chlorophyll is disclosed. Exemplary processes include blending oil containing chlorophyll with fats, followed by hydrolysis and distillation.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: May 24, 2022
    Assignee: NESTE OYJ
    Inventors: Jukka-Pekka Pasanen, Annika Malm, Rami Piilola
  • Patent number: 11312971
    Abstract: The invention provides modified DGAT1 proteins that are modified in the N-terminal region upstream of the acyl-Co A binding site. The modified DGAT proteins show enhanced activity, without reduced protein accumulation when expressed in cells. The modified DGAT1 proteins of the invention can be expressed in cells to increase cellular lipid accumulation and/or modify the cellular lipid profile. The invention also provides polynucleotides encoding the modified DGAT1 proteins, cells and compositions comprising the polynucleotides or modified DGAT proteins, and methods using the modified DGAT1 proteins to produce oil.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: April 26, 2022
    Assignee: Agresearch Limited
    Inventors: Nicholas John Roberts, Amy Christina Curran, Somrutai Winichayakul, Marissa Roldan, Richard William Scott
  • Patent number: 11286292
    Abstract: The present invention relates to a bioreactor arrangement for producing a biopolymer expressed by a cell and a continuous process for a capturing the biopolymer employing two chromatography units operated in series or independently.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: March 29, 2022
    Assignee: CMC BIOLOGICS A/S
    Inventors: Mads Laustsen, Simon Bergmann
  • Patent number: 11286621
    Abstract: Embodiments disclosed herein provide enzymatic formulations comprising a polypeptide having amylase activity for producing a paper product. Also provided are aqueous surface treatment compositions for paper and board comprising degraded starch. Further provided are methods for producing paper and board using the aqueous surface treatment composition, and to corrugated boards produced from this paper.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: March 29, 2022
    Assignee: BASF SE
    Inventors: Christoph Hamers, Konstantino Karanikas, Kenneth Barrett, Zheng Tan
  • Patent number: 11260114
    Abstract: Disclosed herein are compositions and methods for use in therapeutic procedures. Use of a “fast-acting” botulinum toxin for cosmetic treatment and/or to prevent or reduce scarring. “Fast-acting” refers to a botulinum toxin that produces effects in the patient more rapidly than those produced by, for example, a botulinum neurotoxin type A. The “fast-acting” botulinum toxin, for example, type E.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: March 1, 2022
    Assignee: Bonti, Inc.
    Inventors: Sawsan Abushakra, Wajdie Ahmad, Fauad Hasan, Michael Jarpe
  • Patent number: 11236054
    Abstract: The present disclosure relates to a method for preparing aryl 2-tetrazol-2-yl ketone of the following Formula 1a with improved selectivity: wherein R1 and R2 are the same as defined herein.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: February 1, 2022
    Assignee: SK BIOPHARMACEUTICALS CO., LTD.
    Inventors: Kyuwoong Lee, Kyungmi Cha, Suyeon Yeom, Jiseon Woo
  • Patent number: 11208641
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: December 28, 2021
    Assignee: Novozymes, Inc.
    Inventor: Nikolaj Spodsberg
  • Patent number: 11198819
    Abstract: A high-efficiency food waste carbonization process using a carbonizer specially designed to function at a specific range of temperatures to work efficiently, with minimal energy input and designed to reduce volume and to produce charcoal that may be used as a fuel. The invention is designed to work with high-moisture materials such as food waste.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: December 14, 2021
    Assignee: SERENDIPITY TECHNOLOGIES LLC
    Inventor: Amen Dhyllon
  • Patent number: 11193148
    Abstract: The present disclosure provides a method for extracting alpha-ketoglutarate and pyruvate simultaneously from microbial fermentation broth or enzyme transformation solution, which is related to the technical field of biological separation and extraction.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 7, 2021
    Assignee: Jiangnan University
    Inventors: Jingwen Zhou, Jian Chen, Weizhu Zeng, Guocheng Du, Fang Fang, Song Liu
  • Patent number: 11168300
    Abstract: The present invention addresses the issue of providing: a novel microorganism having a high capability to produce urolithins; and a method of producing urolithins using the same, and the issue is solved by a microorganism that belongs to the genus Eggerthella and produces urolithins.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: November 9, 2021
    Assignee: DAICEL CORPORATION
    Inventors: Masatake Kudoh, Takanori Nakajima, Hiroaki Yamamoto
  • Patent number: 11155798
    Abstract: The invention relates to enzyme compositions comprising a glucoamylase, an alpha-amylase, and optionally a cellulolytic composition and/or a protease. The invention also relates to the use thereof in processes of producing sugars and/or fermentation products from starch-containing material by saccharifying and/or fermenting starch-containing material at a temperature below the initial gelatinization temperature.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: October 26, 2021
    Assignee: NOVOZYMES A/S
    Inventors: Joseph Jump, Nathaniel Kreel, Jeremy Saunders, Michael John Akerman
  • Patent number: 11130903
    Abstract: A method of treating a well comprising introducing an aqueous-based well treatment fluid into the well and treating the well with the well treatment fluid is provided. The well treatment fluid comprises an aqueous base fluid, and a treating agent. The treating agent comprises fulvic acid. In one embodiment, the treating agent functions as a scale inhibitor. In another embodiment, the treating agent functions as a gel stabilizer. For example, the method can be a method of fracturing a subterranean formation. For example, the method can be a method of forming a gravel pack in a well. An aqueous-based well treatment fluid is also provided.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: September 28, 2021
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Sairam Eluru, Chetan Prakash
  • Patent number: 11118198
    Abstract: The disclosure relates to a method for fermentation integrated with separation and purification of acetone, butanol, and ethanol (ABE) or butanol alone, comprising the following steps: 1) obtaining ABE by fermentation using an acetone-butanol-producing bacterium or obtaining butanol using a butanol-producing bacterium; 2) using a “vapor-stripping-vapor-permeation” method (briefly VSVP) for online separation and purification of ABE or purifying butanol from the fermentation broth; wherein the VSVP method comprises the following steps: introducing a gas bubble into the fermentation broth comprising active cells for fermentation to vaporize ABE or Butanol; subjecting the gas along with the vaporized ABE or Butanol to a membrane separation unit to pass through the membrane; recovering ABE or Butanol, or subjecting ABE or Butanol to a next separation device.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: September 14, 2021
    Assignee: Dalian University of Technology
    Inventors: Chuang Xue, Chao Zhu, Lijie Chen
  • Patent number: 11008596
    Abstract: The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: May 18, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Pedro S. Coelho, Eric M. Brustad, Frances H. Arnold, Zhan Wang, Jared C. Lewis
  • Patent number: 10980839
    Abstract: The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between ?15° C. and ?100° C. Steps b) to e) are carried out in anaerobiosis.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 20, 2021
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Patricia Lepage, Christel Maillet, Sylvie Rabot, Fernanda Fonseca, Hervé Blottiere
  • Patent number: 10975400
    Abstract: A method for constructing an ALA production bacterial strain, the method enhances the activity of related enzymes promoting the synthesis of oxaloacetate and in the 5-aminolevulinic acid (ALA) production bacterial strain, or introducing exogenous related enzymes promoting the synthesis of oxaloacetate, such as phosphoenolpyruvate carboxylase or pyruvate carboxylase, and/or reducing the activity of related enzymes in the downstream metabolic pathway of succinyl coenzyme A in the bacterial strain, such as succinyl coenzyme A synthetase or succinate dehydrogenase, and/or reducing the activity of phosphoenolpyruvate carboxylated kinase and/or malic enzyme. An ALA high-yield bacterial strain constructed by utilizing the method, and method for utilizing the bacterial strain to prepare ALA.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: April 13, 2021
    Assignee: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
    Inventors: Ping Zheng, Jiuzhou Chen, Wei Pu, Jibin Sun, Xinyang Wu, Yanhe Ma
  • Patent number: 10927388
    Abstract: The present invention relates to a method for preparing bioethanol from lignocellulosic biomass. The method of the present invention is capable of: minimizing the impurity content of an enzymatic saccharification raw material, by extracting biomass using hot water, before pretreatment, and removing extractable substances such as inorganic salts; suppressing, to the greatest extent, the production of overdecomposition products of sugar, by pretreating the biomass, from which the hot water extractable substances have been removed, in a condition for maximizing xylan yield; preparing fermentable sugar at a low cost, without washing a pretreated solid obtained from subsequent solid-liquid separation, but by only concentrating a sugar solution obtained after enzymatic saccharification, using a separation film; and preparing bioethanol therefrom in high yield.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: February 23, 2021
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Ju Hyun Yu, Chan Duck Jung, In Yong Eom, Seung Hwan Lee, Kyung Sik Hong, In-Chul Kim, Jong Geon Jegal, Bong Keun Song
  • Patent number: 10870947
    Abstract: The invention relates to a process for isolation of hemicelluloses from biomass pulping process waters or spent liquors with removal of suspended solids, concentration of the product and purification of the product by removal of inorganic salts and low molecular weight substances. It is characterized in that the hemicellulose isolation process conditions at several separation/purification stages are adjusted separately by e.g. pH adjustment. The invention further relates to a plant for carrying out the process. With such process and plant it is possible to recover most of the suspended solids, especially xylan and other hemicelluloses.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 22, 2020
    Assignee: Andritz AG
    Inventors: Oleg Shagaev, Lukas Wiesegger
  • Patent number: 10844276
    Abstract: The present invention provides environmentally-friendly compositions and methods for degrading polymers used in fracking operations to enhance the recovery of oil and gas. Specifically, the compositions and methods utilized microorganisms and/or heir growth by products to degrade polymers, such as PGA, PLA and PAM, used in fracking wells.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: November 24, 2020
    Assignee: LOCUS OIL IP COMPANY, LLC
    Inventors: Sean Farmer, Ken Alibek, Kent Adams, Karthik N. Karathur, Sharmistha Mazumder
  • Patent number: 10836837
    Abstract: A process for treating crop kernels is comprised of the steps of a) soaking kernels in water to produce soaked kernels; b) grinding the soaked kernels; c) treating the soaked kernels in the presence of an effective amount of GH62 polypeptide having arabinofuranosidase activity or a GH43 polypeptide having arabinofuranosidase activity, wherein step c) is performed before, during or after step b).
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: November 17, 2020
    Assignee: Novozymes A/S
    Inventors: Yi Cao, James Lavigne, Bernardo Vidal, Jr., Thomas Patrick Gibbons, Chee-Leong Soong, Brian R. Scott, Randall Scott Deinhammer, Zhen Long, Michael John Akerman, Xinyu Shen, Yu Zhang
  • Patent number: 10815464
    Abstract: Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 27, 2020
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Su Jin Park, Young Lyeol Yang, Hye Won Um, Hong Xian Li, Kyoung Min Lee, Baek Seok Lee, Hyo Hyoung Lee, Hee Kyoung Jung
  • Patent number: 10801045
    Abstract: The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: October 13, 2020
    Assignee: Ginkgo Bioworks, Inc.
    Inventors: Curt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
  • Patent number: 10793840
    Abstract: Methods to create two component signal transduction systems by replace the DNA binding domains and output promoters in bacteria are described.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: October 6, 2020
    Assignee: William Marsh Rice University
    Inventors: Jeffrey J. Tabor, Sebastian Schmidl, Ravi Sheth, Felix Ekness, Brian Landry, Nikola Dyuglyarov
  • Patent number: 10793884
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: October 6, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xinkai Xie
  • Patent number: 10718780
    Abstract: The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the tyrosine-protein kinase receptor UFO protein (AXL) that are particularly advantageous for quantifying the AXL protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: July 21, 2020
    Assignee: Expression Pathology, Inc.
    Inventors: David B. Krizman, Todd Hembrough, Adele Blackler, Wei-Li Liao
  • Patent number: 10689610
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: June 23, 2020
    Assignee: Calysta, Inc.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman, Graham Ian Aylen
  • Patent number: 10662418
    Abstract: Provided herein are recombinant microorganisms having two or more copies of a nucleic acid sequence encoding xylose isomerase, wherein the nucleic acid encoding the xylose isomerase is an exogenous nucleic acid. Optionally, the recombinant microorganisms include at least one nucleic acid sequence encoding a xylulose kinase and/or at least one nucleic acid sequence encoding a xylose transporter. The provided recombinant microorganisms are capable of growing on xylose as a carbon source.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 26, 2020
    Assignee: Mara Renewables Corporation
    Inventors: Alexandra Merkx-Jacques, David Woodhall, Mark Scaife, Roberto E. Armenta, Denise Muise, Holly Rasmussen, Jeremy Benjamin
  • Patent number: 10656311
    Abstract: A nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures; a second metastructure including a second substrate and a second electrode, wherein the second substrate and the second electrode are substantially transparent to light within a wavelength range; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode a light source configured to selectively apply an excitation light to the microfluidic channel, the excitation light having a wavelength within the wavelength range. In response to the selective application of the electric field and/or the excitation light, nanoparticles within the microfluidic channel are manipulated.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: May 19, 2020
    Assignee: Vanderbilt University
    Inventor: Justus C. Ndukaife
  • Patent number: 10648009
    Abstract: The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: May 12, 2020
    Assignee: Novoyzmes, Inc.
    Inventors: Brett McBrayer, Tarana Shaghasi, Elena Vlasenko
  • Patent number: 10640794
    Abstract: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more carbonic anhydrases are present in the fermentation medium.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: May 5, 2020
    Assignee: NOVOZYMES NORTH AMERICA, INC.
    Inventors: Chee-Leong Soong, Jiyin Liu, Guillermo Coward Kelly
  • Patent number: 10640774
    Abstract: The present invention relates to a recombinant microorganism having the ability to produce poly(lactate-co-glycolate) and its copolymers from xylose, and more particularly to a recombinant microorganism having the ability to produce poly(lactate-co-glycolate) and its copolymers without having to supply a glycolate precursor from an external source, and a method of producing a poly(lactate-co-glycolate) copolymers using the same.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: May 5, 2020
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup Lee, So Young Choi, Si Jae Park
  • Patent number: 10612034
    Abstract: The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the heterologous gene; and methods for identifying promoters.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 7, 2020
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Jane C. Schneider, Bo Liu, Rekha Seshadri
  • Patent number: 10576110
    Abstract: The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of non-replicating L. johnsonii La1 NCC533 (deposit number CNCM I-1225) for use in the treatment or prevention of disorders related to the immune system including infections.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: March 3, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Valerie Petit, Clara Garcia-Rodenas, Monique Julita, Guenolee Prioult, Annick Mercenier, Sophie Nutten
  • Patent number: 10525472
    Abstract: Apparatus, methods, and systems for automated liquid droplet manipulation include an open droplet supporting surface. An actuator can translate the surface in space with at least one degree freedom of movement to influence movement of one or more droplets on the surface. In one embodiment, the surface is patterned with areas that attract the droplets and interstitial areas that repel the droplets to enhance transport of droplets. For example, for water-based droplets the attracting areas can be hydrophilic and the repelling hydrophobic. In one embodiment, the repelling areas are superhydrophobic. Electromechanical movement of the surface avoids expensive and complex microfluidic fabrication and components, and avoids electrowetting requirements.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: January 7, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Santosh Pandey, Riley Brien, Taejoon Kong, Zach Njus, Jared Anderson
  • Patent number: 10519204
    Abstract: A method for preparing a protein isolate of the biomass of microalgae of the genus Chlorella, includes the following steps: supplying a microalgal biomass produced by fermentation, washing the biomass so as to eliminate the soluble interstitial compounds and concentrating the biomass, mechanically grinding the washed and concentrated biomass in a horizontal ball grinder-type system in order to produce an emulsion, destructuring the emulsion thus produced, triple-phase separation so as to separate the soluble fraction from the fractions containing the lipids and the cell debris, recovery of the soluble fraction thus produced in order to produce the soluble protein isolate, then evaporation, pasteurization and atomization of the protein isolate.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: December 31, 2019
    Assignee: CORBION BIOTECH, INC.
    Inventor: Samuel Patinier
  • Patent number: 10511003
    Abstract: A separator which is permeable to hydroxide ion contains at least one Dendrite Stopping Substance such as Ni(OH)2, or its precursor.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: December 17, 2019
    Assignee: AZA HOLDING PTE. LTD.
    Inventors: Didier Guillonnet, Suren Martirosyan
  • Patent number: 10494685
    Abstract: The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: December 3, 2019
    Assignee: NOVOZYMES A/S
    Inventors: Shikha Gupta, Allan Svendsen, Vivek Srivastava, Marco Malten, Thomas Agersten Poulsen, Preethi Ramaiya, Beth Nelson, Vasudeva P. Rao, Padmavathi Balumuri
  • Patent number: 10457926
    Abstract: The present application provides novel polypeptides having xylanase activity and the respective nucleic acid sequences encoding those polypeptides as well as vectors comprising these nucleic acid sequences and host cells transformed by these vectors. In addition the present invention provides a method for producing these polypeptides and a composition comprising the inventive polypeptides.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: October 29, 2019
    Assignee: Clariant Produkte (Deutschland) GmbH
    Inventors: Christoph Reisinger, Christian Gamauf, Michael Kraus, Isabel Unterstrasser, Aleksandra Mitrovic, Anton Glieder
  • Patent number: 10392645
    Abstract: Disclosed is a simplified method for producing a protein hydrolysate, the method having the advantages of decreasing costs associated with energy, materials, and space as compared to that of conventional methods. A protein hydrolysate/enzyme composition is also disclosed.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: August 27, 2019
    Assignee: GLANBIA NUTRITIONALS(IRELAND) LTD.
    Inventors: Brent L. Petersen, Niels J. Palmer, Byron M. Toledo, Jerry O'Dea, Loren S. Ward