Micro-organism, Tissue Cell Culture Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition Patents (Class 435/41)
  • Patent number: 11312971
    Abstract: The invention provides modified DGAT1 proteins that are modified in the N-terminal region upstream of the acyl-Co A binding site. The modified DGAT proteins show enhanced activity, without reduced protein accumulation when expressed in cells. The modified DGAT1 proteins of the invention can be expressed in cells to increase cellular lipid accumulation and/or modify the cellular lipid profile. The invention also provides polynucleotides encoding the modified DGAT1 proteins, cells and compositions comprising the polynucleotides or modified DGAT proteins, and methods using the modified DGAT1 proteins to produce oil.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: April 26, 2022
    Assignee: Agresearch Limited
    Inventors: Nicholas John Roberts, Amy Christina Curran, Somrutai Winichayakul, Marissa Roldan, Richard William Scott
  • Patent number: 11286292
    Abstract: The present invention relates to a bioreactor arrangement for producing a biopolymer expressed by a cell and a continuous process for a capturing the biopolymer employing two chromatography units operated in series or independently.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: March 29, 2022
    Assignee: CMC BIOLOGICS A/S
    Inventors: Mads Laustsen, Simon Bergmann
  • Patent number: 11286621
    Abstract: Embodiments disclosed herein provide enzymatic formulations comprising a polypeptide having amylase activity for producing a paper product. Also provided are aqueous surface treatment compositions for paper and board comprising degraded starch. Further provided are methods for producing paper and board using the aqueous surface treatment composition, and to corrugated boards produced from this paper.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: March 29, 2022
    Assignee: BASF SE
    Inventors: Christoph Hamers, Konstantino Karanikas, Kenneth Barrett, Zheng Tan
  • Patent number: 11260114
    Abstract: Disclosed herein are compositions and methods for use in therapeutic procedures. Use of a “fast-acting” botulinum toxin for cosmetic treatment and/or to prevent or reduce scarring. “Fast-acting” refers to a botulinum toxin that produces effects in the patient more rapidly than those produced by, for example, a botulinum neurotoxin type A. The “fast-acting” botulinum toxin, for example, type E.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: March 1, 2022
    Assignee: Bonti, Inc.
    Inventors: Sawsan Abushakra, Wajdie Ahmad, Fauad Hasan, Michael Jarpe
  • Patent number: 11236054
    Abstract: The present disclosure relates to a method for preparing aryl 2-tetrazol-2-yl ketone of the following Formula 1a with improved selectivity: wherein R1 and R2 are the same as defined herein.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: February 1, 2022
    Assignee: SK BIOPHARMACEUTICALS CO., LTD.
    Inventors: Kyuwoong Lee, Kyungmi Cha, Suyeon Yeom, Jiseon Woo
  • Patent number: 11208641
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: December 28, 2021
    Assignee: Novozymes, Inc.
    Inventor: Nikolaj Spodsberg
  • Patent number: 11198819
    Abstract: A high-efficiency food waste carbonization process using a carbonizer specially designed to function at a specific range of temperatures to work efficiently, with minimal energy input and designed to reduce volume and to produce charcoal that may be used as a fuel. The invention is designed to work with high-moisture materials such as food waste.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: December 14, 2021
    Assignee: SERENDIPITY TECHNOLOGIES LLC
    Inventor: Amen Dhyllon
  • Patent number: 11193148
    Abstract: The present disclosure provides a method for extracting alpha-ketoglutarate and pyruvate simultaneously from microbial fermentation broth or enzyme transformation solution, which is related to the technical field of biological separation and extraction.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 7, 2021
    Assignee: Jiangnan University
    Inventors: Jingwen Zhou, Jian Chen, Weizhu Zeng, Guocheng Du, Fang Fang, Song Liu
  • Patent number: 11168300
    Abstract: The present invention addresses the issue of providing: a novel microorganism having a high capability to produce urolithins; and a method of producing urolithins using the same, and the issue is solved by a microorganism that belongs to the genus Eggerthella and produces urolithins.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: November 9, 2021
    Assignee: DAICEL CORPORATION
    Inventors: Masatake Kudoh, Takanori Nakajima, Hiroaki Yamamoto
  • Patent number: 11155798
    Abstract: The invention relates to enzyme compositions comprising a glucoamylase, an alpha-amylase, and optionally a cellulolytic composition and/or a protease. The invention also relates to the use thereof in processes of producing sugars and/or fermentation products from starch-containing material by saccharifying and/or fermenting starch-containing material at a temperature below the initial gelatinization temperature.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: October 26, 2021
    Assignee: NOVOZYMES A/S
    Inventors: Joseph Jump, Nathaniel Kreel, Jeremy Saunders, Michael John Akerman
  • Patent number: 11130903
    Abstract: A method of treating a well comprising introducing an aqueous-based well treatment fluid into the well and treating the well with the well treatment fluid is provided. The well treatment fluid comprises an aqueous base fluid, and a treating agent. The treating agent comprises fulvic acid. In one embodiment, the treating agent functions as a scale inhibitor. In another embodiment, the treating agent functions as a gel stabilizer. For example, the method can be a method of fracturing a subterranean formation. For example, the method can be a method of forming a gravel pack in a well. An aqueous-based well treatment fluid is also provided.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: September 28, 2021
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Sairam Eluru, Chetan Prakash
  • Patent number: 11118198
    Abstract: The disclosure relates to a method for fermentation integrated with separation and purification of acetone, butanol, and ethanol (ABE) or butanol alone, comprising the following steps: 1) obtaining ABE by fermentation using an acetone-butanol-producing bacterium or obtaining butanol using a butanol-producing bacterium; 2) using a “vapor-stripping-vapor-permeation” method (briefly VSVP) for online separation and purification of ABE or purifying butanol from the fermentation broth; wherein the VSVP method comprises the following steps: introducing a gas bubble into the fermentation broth comprising active cells for fermentation to vaporize ABE or Butanol; subjecting the gas along with the vaporized ABE or Butanol to a membrane separation unit to pass through the membrane; recovering ABE or Butanol, or subjecting ABE or Butanol to a next separation device.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: September 14, 2021
    Assignee: Dalian University of Technology
    Inventors: Chuang Xue, Chao Zhu, Lijie Chen
  • Patent number: 11008596
    Abstract: The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: May 18, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Pedro S. Coelho, Eric M. Brustad, Frances H. Arnold, Zhan Wang, Jared C. Lewis
  • Patent number: 10980839
    Abstract: The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between ?15° C. and ?100° C. Steps b) to e) are carried out in anaerobiosis.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 20, 2021
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Patricia Lepage, Christel Maillet, Sylvie Rabot, Fernanda Fonseca, Hervé Blottiere
  • Patent number: 10975400
    Abstract: A method for constructing an ALA production bacterial strain, the method enhances the activity of related enzymes promoting the synthesis of oxaloacetate and in the 5-aminolevulinic acid (ALA) production bacterial strain, or introducing exogenous related enzymes promoting the synthesis of oxaloacetate, such as phosphoenolpyruvate carboxylase or pyruvate carboxylase, and/or reducing the activity of related enzymes in the downstream metabolic pathway of succinyl coenzyme A in the bacterial strain, such as succinyl coenzyme A synthetase or succinate dehydrogenase, and/or reducing the activity of phosphoenolpyruvate carboxylated kinase and/or malic enzyme. An ALA high-yield bacterial strain constructed by utilizing the method, and method for utilizing the bacterial strain to prepare ALA.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: April 13, 2021
    Assignee: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
    Inventors: Ping Zheng, Jiuzhou Chen, Wei Pu, Jibin Sun, Xinyang Wu, Yanhe Ma
  • Patent number: 10927388
    Abstract: The present invention relates to a method for preparing bioethanol from lignocellulosic biomass. The method of the present invention is capable of: minimizing the impurity content of an enzymatic saccharification raw material, by extracting biomass using hot water, before pretreatment, and removing extractable substances such as inorganic salts; suppressing, to the greatest extent, the production of overdecomposition products of sugar, by pretreating the biomass, from which the hot water extractable substances have been removed, in a condition for maximizing xylan yield; preparing fermentable sugar at a low cost, without washing a pretreated solid obtained from subsequent solid-liquid separation, but by only concentrating a sugar solution obtained after enzymatic saccharification, using a separation film; and preparing bioethanol therefrom in high yield.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: February 23, 2021
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Ju Hyun Yu, Chan Duck Jung, In Yong Eom, Seung Hwan Lee, Kyung Sik Hong, In-Chul Kim, Jong Geon Jegal, Bong Keun Song
  • Patent number: 10870947
    Abstract: The invention relates to a process for isolation of hemicelluloses from biomass pulping process waters or spent liquors with removal of suspended solids, concentration of the product and purification of the product by removal of inorganic salts and low molecular weight substances. It is characterized in that the hemicellulose isolation process conditions at several separation/purification stages are adjusted separately by e.g. pH adjustment. The invention further relates to a plant for carrying out the process. With such process and plant it is possible to recover most of the suspended solids, especially xylan and other hemicelluloses.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 22, 2020
    Assignee: Andritz AG
    Inventors: Oleg Shagaev, Lukas Wiesegger
  • Patent number: 10844276
    Abstract: The present invention provides environmentally-friendly compositions and methods for degrading polymers used in fracking operations to enhance the recovery of oil and gas. Specifically, the compositions and methods utilized microorganisms and/or heir growth by products to degrade polymers, such as PGA, PLA and PAM, used in fracking wells.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: November 24, 2020
    Assignee: LOCUS OIL IP COMPANY, LLC
    Inventors: Sean Farmer, Ken Alibek, Kent Adams, Karthik N. Karathur, Sharmistha Mazumder
  • Patent number: 10836837
    Abstract: A process for treating crop kernels is comprised of the steps of a) soaking kernels in water to produce soaked kernels; b) grinding the soaked kernels; c) treating the soaked kernels in the presence of an effective amount of GH62 polypeptide having arabinofuranosidase activity or a GH43 polypeptide having arabinofuranosidase activity, wherein step c) is performed before, during or after step b).
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: November 17, 2020
    Assignee: Novozymes A/S
    Inventors: Yi Cao, James Lavigne, Bernardo Vidal, Jr., Thomas Patrick Gibbons, Chee-Leong Soong, Brian R. Scott, Randall Scott Deinhammer, Zhen Long, Michael John Akerman, Xinyu Shen, Yu Zhang
  • Patent number: 10815464
    Abstract: Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 27, 2020
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Su Jin Park, Young Lyeol Yang, Hye Won Um, Hong Xian Li, Kyoung Min Lee, Baek Seok Lee, Hyo Hyoung Lee, Hee Kyoung Jung
  • Patent number: 10801045
    Abstract: The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: October 13, 2020
    Assignee: Ginkgo Bioworks, Inc.
    Inventors: Curt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
  • Patent number: 10793884
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: October 6, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi Tang, Xinkai Xie
  • Patent number: 10793840
    Abstract: Methods to create two component signal transduction systems by replace the DNA binding domains and output promoters in bacteria are described.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: October 6, 2020
    Assignee: William Marsh Rice University
    Inventors: Jeffrey J. Tabor, Sebastian Schmidl, Ravi Sheth, Felix Ekness, Brian Landry, Nikola Dyuglyarov
  • Patent number: 10718780
    Abstract: The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the tyrosine-protein kinase receptor UFO protein (AXL) that are particularly advantageous for quantifying the AXL protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: July 21, 2020
    Assignee: Expression Pathology, Inc.
    Inventors: David B. Krizman, Todd Hembrough, Adele Blackler, Wei-Li Liao
  • Patent number: 10689610
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: June 23, 2020
    Assignee: Calysta, Inc.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman, Graham Ian Aylen
  • Patent number: 10662418
    Abstract: Provided herein are recombinant microorganisms having two or more copies of a nucleic acid sequence encoding xylose isomerase, wherein the nucleic acid encoding the xylose isomerase is an exogenous nucleic acid. Optionally, the recombinant microorganisms include at least one nucleic acid sequence encoding a xylulose kinase and/or at least one nucleic acid sequence encoding a xylose transporter. The provided recombinant microorganisms are capable of growing on xylose as a carbon source.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 26, 2020
    Assignee: Mara Renewables Corporation
    Inventors: Alexandra Merkx-Jacques, David Woodhall, Mark Scaife, Roberto E. Armenta, Denise Muise, Holly Rasmussen, Jeremy Benjamin
  • Patent number: 10656311
    Abstract: A nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures; a second metastructure including a second substrate and a second electrode, wherein the second substrate and the second electrode are substantially transparent to light within a wavelength range; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode a light source configured to selectively apply an excitation light to the microfluidic channel, the excitation light having a wavelength within the wavelength range. In response to the selective application of the electric field and/or the excitation light, nanoparticles within the microfluidic channel are manipulated.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: May 19, 2020
    Assignee: Vanderbilt University
    Inventor: Justus C. Ndukaife
  • Patent number: 10648009
    Abstract: The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: May 12, 2020
    Assignee: Novoyzmes, Inc.
    Inventors: Brett McBrayer, Tarana Shaghasi, Elena Vlasenko
  • Patent number: 10640794
    Abstract: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more carbonic anhydrases are present in the fermentation medium.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: May 5, 2020
    Assignee: NOVOZYMES NORTH AMERICA, INC.
    Inventors: Chee-Leong Soong, Jiyin Liu, Guillermo Coward Kelly
  • Patent number: 10640774
    Abstract: The present invention relates to a recombinant microorganism having the ability to produce poly(lactate-co-glycolate) and its copolymers from xylose, and more particularly to a recombinant microorganism having the ability to produce poly(lactate-co-glycolate) and its copolymers without having to supply a glycolate precursor from an external source, and a method of producing a poly(lactate-co-glycolate) copolymers using the same.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: May 5, 2020
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup Lee, So Young Choi, Si Jae Park
  • Patent number: 10612034
    Abstract: The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the heterologous gene; and methods for identifying promoters.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 7, 2020
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Jane C. Schneider, Bo Liu, Rekha Seshadri
  • Patent number: 10576110
    Abstract: The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of non-replicating L. johnsonii La1 NCC533 (deposit number CNCM I-1225) for use in the treatment or prevention of disorders related to the immune system including infections.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: March 3, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Valerie Petit, Clara Garcia-Rodenas, Monique Julita, Guenolee Prioult, Annick Mercenier, Sophie Nutten
  • Patent number: 10525472
    Abstract: Apparatus, methods, and systems for automated liquid droplet manipulation include an open droplet supporting surface. An actuator can translate the surface in space with at least one degree freedom of movement to influence movement of one or more droplets on the surface. In one embodiment, the surface is patterned with areas that attract the droplets and interstitial areas that repel the droplets to enhance transport of droplets. For example, for water-based droplets the attracting areas can be hydrophilic and the repelling hydrophobic. In one embodiment, the repelling areas are superhydrophobic. Electromechanical movement of the surface avoids expensive and complex microfluidic fabrication and components, and avoids electrowetting requirements.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: January 7, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Santosh Pandey, Riley Brien, Taejoon Kong, Zach Njus, Jared Anderson
  • Patent number: 10519204
    Abstract: A method for preparing a protein isolate of the biomass of microalgae of the genus Chlorella, includes the following steps: supplying a microalgal biomass produced by fermentation, washing the biomass so as to eliminate the soluble interstitial compounds and concentrating the biomass, mechanically grinding the washed and concentrated biomass in a horizontal ball grinder-type system in order to produce an emulsion, destructuring the emulsion thus produced, triple-phase separation so as to separate the soluble fraction from the fractions containing the lipids and the cell debris, recovery of the soluble fraction thus produced in order to produce the soluble protein isolate, then evaporation, pasteurization and atomization of the protein isolate.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: December 31, 2019
    Assignee: CORBION BIOTECH, INC.
    Inventor: Samuel Patinier
  • Patent number: 10511003
    Abstract: A separator which is permeable to hydroxide ion contains at least one Dendrite Stopping Substance such as Ni(OH)2, or its precursor.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: December 17, 2019
    Assignee: AZA HOLDING PTE. LTD.
    Inventors: Didier Guillonnet, Suren Martirosyan
  • Patent number: 10494685
    Abstract: The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: December 3, 2019
    Assignee: NOVOZYMES A/S
    Inventors: Shikha Gupta, Allan Svendsen, Vivek Srivastava, Marco Malten, Thomas Agersten Poulsen, Preethi Ramaiya, Beth Nelson, Vasudeva P. Rao, Padmavathi Balumuri
  • Patent number: 10457926
    Abstract: The present application provides novel polypeptides having xylanase activity and the respective nucleic acid sequences encoding those polypeptides as well as vectors comprising these nucleic acid sequences and host cells transformed by these vectors. In addition the present invention provides a method for producing these polypeptides and a composition comprising the inventive polypeptides.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: October 29, 2019
    Assignee: Clariant Produkte (Deutschland) GmbH
    Inventors: Christoph Reisinger, Christian Gamauf, Michael Kraus, Isabel Unterstrasser, Aleksandra Mitrovic, Anton Glieder
  • Patent number: 10392645
    Abstract: Disclosed is a simplified method for producing a protein hydrolysate, the method having the advantages of decreasing costs associated with energy, materials, and space as compared to that of conventional methods. A protein hydrolysate/enzyme composition is also disclosed.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: August 27, 2019
    Assignee: GLANBIA NUTRITIONALS(IRELAND) LTD.
    Inventors: Brent L. Petersen, Niels J. Palmer, Byron M. Toledo, Jerry O'Dea, Loren S. Ward
  • Patent number: 10266562
    Abstract: The present invention relates to a purification and concentration method for proteins and antibodies. Particularly the present invention relates to a continuous surfactant based phase separation method for recovering hydrophobin fusion proteins, and for recovering target molecules, such as antibodies, directly from a liquid by using phase separation and hydrophobin-Protein A fusion technologies.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: April 23, 2019
    Assignee: Teknologian tutkimuskeskus VTT Oy
    Inventors: Jussi Joensuu, Markus Linder, Eero Mustalahti, Katri Kurppa
  • Patent number: 10240411
    Abstract: A trimodal hybrid particle mix loss prevention material (LPM) is provided. The trimodal hybrid particle mix LPM includes date palm seed particles produced from date palm seeds, scrap tire particles produced from scrap tires, and date tree pruning waste particles produced from date tree pruning waste. The LCM may include date palm seed particles in the range of about 40 wt % to about 50%, scrap tire particles in the range of about 30 wt % to about 40 wt %, and date tree pruning waste particles in the range of about 15 wt % to about 25 wt %. Methods of loss prevention and manufacture of a trimodal hybrid particle mix LPM are also provided.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: March 26, 2019
    Assignee: Saudi Arabian Oil Company
    Inventor: Md Amanullah
  • Patent number: 10208294
    Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: February 19, 2019
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Mathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano
  • Patent number: 10184103
    Abstract: A fermenter and a method of fermentation in a U-shape and/or nozzle U-loop fermenter (100) comprising a U-part having an essentially vertical down-flow part (101), an essentially vertical up-flow part (102) and a substantially horizontal connecting part (103), which connects the lower ends of the down-flow part (101) and the up-flow part (102), a top part (104) which is provided above the U-part and has a diameter which is substantially larger than the diameter of the U-part, means for creating liquid circulation in U-part of the fermenter, and one or more gas injection points (110) for the introduction and dispersion of the gas(ses) into the fermentation liquid. The pressure may be controlled differently in certain zones of the fermenter by pressure controlling devices (105, 106, 108) e.g.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: January 22, 2019
    Assignee: UNIBO A/S
    Inventor: Ebbe Busch Larsen
  • Patent number: 10130080
    Abstract: The application provides, among others, methods for constructing animal obesity models, methods for screening microorganism or composition of microorganisms that may cause obesity, methods for screening therapeutic targets for treating metabolic disorders, and methods for screening or evaluating microorganisms, compounds, food, recipes, formulations, drugs, nutritional supplements, healthcare products, beverages and other items for preventing and treating metabolic diseases.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: November 20, 2018
    Assignees: SHANGHAI JIAO TONG UNIVERSITY, PERFECT (CHINA) CO., LTD.
    Inventors: Liping Zhao, Na Fei
  • Patent number: 10117399
    Abstract: A novel soybean variety, designated 5PLET90 is provided. Also provided are the seeds of soybean variety 5PLET90, cells from soybean variety 5PLET90, plants of soybean 5PLET90, and plant parts of soybean variety 5PLET90. Methods provided include producing a soybean plant by crossing soybean variety 5PLET90 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PLET90, methods for producing other soybean varieties or plant parts derived from soybean variety 5PLET90, and methods of characterizing soybean variety 5PLET90. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PLET90 are further provided.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: November 6, 2018
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Thomas Charles Corbin, Leslie Charles Kuhlman, Tara Lynch Slaminko
  • Patent number: 10100295
    Abstract: Provided is a modified xylanase. The polypeptide has xylanase activity and has an amino acid sequence with deletion of at least 12 consecutive amino acid residues at the C-terminus of the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO: 1.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: October 16, 2018
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hiroyuki Inoue, Tatsuya Fujii, Kazuhiko Ishikawa
  • Patent number: 10093639
    Abstract: Furfural is produced from biomass material containing pentosan, in high yields, in a production process comprising treating the biomass with a solution containing at least one ?-hydroxysulfonic acid thereby hydrolyzing the biomass to produce a product stream containing at least one C5-carbohydrate compound in monomeric and/or oligomeric form, and dehydrating the C5-carbohydrate compound in the presence of an acid, in a biphasic reaction medium comprising an aqueous phase and a water-immiscible organic phase, at a temperature in the range of from about 100° C. to about 250° C. to produce a dehydration product stream containing furfural. An aqueous stream is separated from the dehydration product that can be optionally recycled to the hydrolysis step.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: October 9, 2018
    Assignee: SHELL OIL COMPANY
    Inventors: Juben Nemchand Chheda, Jean Paul Andre Marie Joseph Ghislain Lange, Paul Richard Weider, Robert Lawrence Blackbourn
  • Patent number: 10088493
    Abstract: A method for cell-free protein synthesis is characterized in that pH is controlled by using an enzyme. For example, by using an amino acid decarboxylase, the pH is controlled according to removal of hydrogen ions that are produced during regeneration of ATP. The method for cell-free protein synthesis of the present invention has an advantage that not only the expression amount of protein is enhanced but also the expressed protein can be directly used for activity analysis without undergoing any separation or purification.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 2, 2018
    Assignee: THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY
    Inventors: Dong-Myung Kim, Taek Jin Kang, Ho-Cheol Kim, Ki Baek Lee
  • Patent number: 10045505
    Abstract: A novel soybean variety, designated 5PGBK62 is provided. Also provided are the seeds of soybean variety 5PGBK62, cells from soybean variety 5PGBK62, plants of soybean 5PGBK62, and plant parts of soybean variety 5PGBK62. Methods provided include producing a soybean plant by crossing soybean variety 5PGBK62 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PGBK62, methods for producing other soybean varieties or plant parts derived from soybean variety 5PGBK62, and methods of characterizing soybean variety 5PGBK62. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PGBK62 are further provided.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: August 14, 2018
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Thomas Charles Corbin, Tara Lynch Slaminko
  • Patent number: 10006062
    Abstract: Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme, and where the enzyme controls flux in the pathway of interest.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: June 26, 2018
    Assignees: The Board of Trustees of the Leland Stanford Junior University, GreenLight Biosciences, Inc.
    Inventor: James R. Swartz
  • Patent number: 10000778
    Abstract: The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile systems for producing ethanol from biomass are provided. Also provided are small-scale ethanol production facilities. For example, instead of transporting biomass to the production facility, the facility is transported to the biomass or is located nearby the source of the biomass. The ethanol production facilities or components thereof may be transported via land, water, or air. Production of other products, such as hydrocarbons, natural gas, hydrogen gas, plastics, polymers, and proteins, can also be made by the methods and facilities. Any product described herein can be made in finished form or un-finished form and moved, e.g., to a fixed facility, e.g.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: June 19, 2018
    Assignee: XYLECO, INC.
    Inventor: Marshall Medoff