Using Actinomycetales Patents (Class 435/169)
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Patent number: 4666715Abstract: An antibiotic AM-5344-A.sub.2 substance, and a process for the preparation of the antibiotic AM-5344-A.sub.2 substance are described. The antibiotic AM-5344-A.sub.2 substance is prepared by cultivating an AM-5344-A.sub.2 substance-producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. Am-5344 in a nutrient medium, and recovering the Am-5344-A.sub.2 substance from the culture.Type: GrantFiled: June 24, 1983Date of Patent: May 19, 1987Assignee: Kitasato InstituteInventors: Satoshi Omura, Yuzuru Iwai, Kiyoizumi Hinotozawa, Atsushi Hirano
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Patent number: 4661353Abstract: CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound of CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions.CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line.A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.Type: GrantFiled: December 4, 1985Date of Patent: April 28, 1987Assignee: Warner-Lambert CompanyInventors: John H. Wilton, Gerard C. Hokanson, James C. French
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Patent number: 4661352Abstract: This invention relates to a biologically active WS-7739-A substance and a biologically active WS-7739-B substance which have pharmacological activities and are useful for the treatment of asthma, thrombosis and the alike.Type: GrantFiled: October 19, 1984Date of Patent: April 28, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Motoaki Nishikawa, Morita Iwami, Keizo Yoshida, Masanobu Kohsaka
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Patent number: 4656036Abstract: The antibiotics Tejeramycin are active against gram negative and gram positive infections, especially against Pseudomonas aeruginosa. The antibiotics Tejeramycin are produced by the aerobic fermentation of Streptomyces griseus ATCC No. 39208 or 39209 in an assimilable aqueous nutrient medium.Type: GrantFiled: January 11, 1985Date of Patent: April 7, 1987Assignee: Merck & Co., Inc.Inventors: Kenneth E. Wilson, Sheldon B. Zimmerman
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Patent number: 4654211Abstract: Antibiotic FR-900451 is produced by Streptomyces griseorubiginosus No. 43708 (FERM BP-699).Type: GrantFiled: November 30, 1984Date of Patent: March 31, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masami Ezaki, Seiji Hashimoto, Tadaaki Komori, Kazuyoshi Umehara, Masanobu Kohsaka
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Patent number: 4631256Abstract: BBM-928 is a mixture of antitumor antibacterial substances produced by fermentation of Actinomadura sp., ATCC No. 31491, under controlled conditions. The components may be separated by silica gel thin layer chromatography and by other means.Type: GrantFiled: October 6, 1983Date of Patent: December 23, 1986Assignee: Bristol-Myers CompanyInventors: Hideo Koshiyama, Fumihide Sakai, Hiroaki Ohkuma
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Patent number: 4615975Abstract: A purified isolate of Actinomadura verrucaspora subspecies veractimycin is capable of producing a complex of sulfur-containing antibiotic compounds having anti-tumor activity in recoverable amounts when cultivated under aerobic conditions in a culture medium containing assimilable sources of carbon, nitrogen, and sulfur.Type: GrantFiled: October 29, 1984Date of Patent: October 7, 1986Assignee: Warner-Lambert CompanyInventor: Josefino B. Tunac
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Patent number: 4614717Abstract: Products which are soluble without opalescence even at pH 3 and which, because of their reproducible composition, are particularly well suited as a source of nitrogen for organisms are obtained by enzymatic degradation of uniform microbial cell aggregates, using endoproteases, and isolation of the protein fraction up to 2,000 Dalton, preferably from 400 to 1,500 Dalton.Type: GrantFiled: February 28, 1985Date of Patent: September 30, 1986Assignee: Hoechst AktiengesellschaftInventors: Traudel Kachholz, Udo Scharf, Merten Schlingmann
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Patent number: 4613503Abstract: Antibiotic A26201-1 and antibiotic A26201-2 are produced by the novel microorganism, Actinoplanes species A26201 (ATCC 39573), under aqueous aerobic fermentation conditions. The antibiotics are useful for inhibiting bacteria, particularly gram positive bacteria, and are also useful for promoting the growth of monogastric and ruminant animals.Type: GrantFiled: October 11, 1984Date of Patent: September 23, 1986Assignee: The Dow Chemical CompanyInventors: Joseph W. Whalen, Gregory L. Swartz, Lisa J. Rheaume, Karen M. McCoy
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Patent number: 4608343Abstract: This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.Type: GrantFiled: May 30, 1985Date of Patent: August 26, 1986Assignee: American Cyanamid CompanyInventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
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Patent number: 4607012Abstract: The present invention concerns a new antibiotic substance arbitrarily designated as antibiotic SB 22484, to a process for its production by culturing Streptomyces sp. NRRL 15496 or a producing variant or mutant thereof, and to the use of the new antibiotic substance in the treatment of infectious diseases involving microorganisms susceptible to this antibiotic substance.Type: GrantFiled: August 30, 1984Date of Patent: August 19, 1986Assignee: Gruppo Lepetit S.p.A.Inventors: Enrico Selva, Grazia Beretta, Giorgio Tamoni, Vittorio Arioli, Giovanni Cassani, Francesco Parenti
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Patent number: 4605559Abstract: The invention relates to a new compound, FR-900447, and pharmaceutically acceptable salts thereof having antimicrobial and antitumor activity, to a pharmaceutically composition thereof, and to a process for production thereof by culturing Streptomyces rubropurpureus FERM BP-584 in nutrient medium under aerobic condition.Type: GrantFiled: August 31, 1984Date of Patent: August 12, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yasuhiro Hori, Motohiro Hino, Hiroshi Terano, Masashi Hashimoto, Masanobu Kohsaka
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Patent number: 4597968Abstract: The antibiotic 13-384 complex is elaborated by a new variety of Micromonospora carbonacea; namely Micromonospora carbonacea var africana NRRL 15099.Type: GrantFiled: June 21, 1984Date of Patent: July 1, 1986Assignee: Schering CorporationInventors: Jay A. Waitz, Mahesh G. Patel, Joseph A. Marquez, Manohar G. Kalyanpur, Ann C. Horan
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Patent number: 4594248Abstract: CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound or CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions.CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line.A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.Type: GrantFiled: March 15, 1985Date of Patent: June 10, 1986Assignee: Warner-Lambert CompanyInventors: John H. Wilton, Gerard C. Hokanson, James C. French
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Patent number: 4578271Abstract: Novel compounds designated as WS 6049-A and WS 6049-B are disclosed, as well as compositions containing the compounds thereof, a method of treating microbial infections, a method of prolonging the survival time of the patient with lymphocytic leukemia by administering the compounds thereof, and a process for making the WS 6049 substances, are disclosed. As indicated above, the novel compounds have antimicrobial and antileukemic activities which make them useful against a variety of pathogenic microorganisms and leukemic tumors.Type: GrantFiled: May 3, 1983Date of Patent: March 25, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Sumio Kiyoto, Motoaki Nishikawa, Morita Iwami, Hiroshi Terano, Masanobu Kohsaka
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Patent number: 4565699Abstract: Novel antibiotic U-68,204 is produced in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces thiolactonus, NRRL 15439. This antibiotic is active against various Gram-positive bacteria. Thus, antibiotic U-68,204 can be used in various environments to eradicate or control such bacteria.Type: GrantFiled: July 18, 1983Date of Patent: January 21, 1986Assignee: The Upjohn CompanyInventors: Lester A. Dolak, Alice L. Laborde, Oldrich K. Sebek, Thomas M. Castle, Thomas F. Brodasky
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Patent number: 4557933Abstract: A novel compound, called chloropolysporin, has antibiotic properties and would appear to be a member of the class of glycopeptide antibiotics containing chlorine. It may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). It may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.Type: GrantFiled: July 3, 1984Date of Patent: December 10, 1985Assignee: Sankyo Company LimitedInventors: Tatsuo Haneishi, Takao Okazaki, Akio Torikata, Mutsuo Nakajima, Ryuzou Enokita, Toshiaki Katayama, Seigo Iwado
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Patent number: 4555402Abstract: A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.Type: GrantFiled: August 10, 1984Date of Patent: November 26, 1985Assignee: Kyowa Hakko Kogyo Co. Ltd.Inventors: Yuzuru Matsuda, Kazuyuki Iwahashi, Takao Iida, Noriaki Hirayama, Kozo Asano, Katsuichi Shuto, Koji Yamada, Kunikatsu Shirahata, Hiroshi Kase
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Patent number: 4554162Abstract: A strain of actinomycete, NRRL 15758, is capable of producing the CL-1724 complex of compounds under conditions of aerobic fermentation in the presence of assimilable sources of carbon and nitrogen. The compound CL-1724B-2 exhibiting antimicrobial and antitumor activity, is claimed together with pharmaceutical compositions and methods of treating microbial infections and tumors in mammals employing these pharmaceutical compositions.Type: GrantFiled: May 4, 1984Date of Patent: November 19, 1985Assignee: Warner-Lambert CompanyInventors: Cynthia A. Young, John P. Schaumberg, Gerard C. Hokanson, James C. French, Josefino B. Tunac
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Patent number: 4550021Abstract: Antibiotic 81-484 of the following physico-chemical properties:(1) elementary analysis: C.sub.33 H.sub.48 O.sub.7 (high resolution mass spectrum);(2) molecular weight: 556 [Field desorption (FD) mass spectrum];(3) melting point: not clear (oily at 10.degree.-100.degree. C.);(4) specific rotation: [.alpha.].sub.D.sup.20 =-151.degree. (c=0.1, methanol);(5) ultraviolet absorption spectrum: shown in FIG. 1 (in methanol);(6) infrared absorption spectrum: shown in FIG. 2 (KBr tablet);(7) solubility: insoluble in hexane and water, soluble in diethyl ether, methanol, ethanol, dichloromethane, chloroform, ethyl acetate, butyl acetate, acetone and benzene;(8) nuclear magnetic resonance spectrum: shown in FIG. 3 (CDCl.sub.3, TMS);(9) nature: acidic substance;(10) color reaction:negative for ninhydrin, anthrone-H.sub.2 SO.sub.Type: GrantFiled: June 5, 1984Date of Patent: October 29, 1985Assignee: The Kitasato InstituteInventors: Iwao Umezawa, Kanki Komiyama
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Patent number: 4548816Abstract: Novel antibiotic SF-2288 is produced by fermentation of an actinomycete belonging to the genus Actinomadura in nutrient medium. Based on its physico-chemical and biological properties, antibiotic SF-2288 possesses an excellent antimicrobial activity against Gram-positive and Gram-negative microorganisms and antiviral activity.Type: GrantFiled: June 21, 1984Date of Patent: October 22, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasumitsu Kondo, Takashi Shomura, Junko Yoshida, Kazuo Okano, Masaji Sezaki, Tatsuo Itoh
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Patent number: 4548974Abstract: A novel antibiotic complex of "Vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.Type: GrantFiled: July 13, 1983Date of Patent: October 22, 1985Assignee: SmithKline Beckman CorporationInventors: Betty A. Bowie, David J. Newman, Marcia C. Shearer, Robert D. Sitrin, Joseph R. Valenta
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Patent number: 4540575Abstract: New fermentation products useful in the treatment of tardive dyskinesia by inhibition of choline oxidase are produced by fermentation of a nutrient medium with a microorganism, Streptomyces hygroscopicus.Type: GrantFiled: May 6, 1983Date of Patent: September 10, 1985Assignee: Merck & Co., Inc.Inventors: Richard L. Monaghan, Yu-Lin Kong
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Patent number: 4539203Abstract: Compounds CL-1577D and CL-1577E are prepared by cultivation of a purified isolate of Actinomycete designated ATCC 39363 in a culture medium having assimilable sources of carbon and nitrogen. The compounds are effective antimicrobial agents and possess cytotoxic activity against L1210 murine leukemia cells and P388 murine leukemia cells.Type: GrantFiled: November 13, 1984Date of Patent: September 3, 1985Assignee: Warner-Lambert CompanyInventors: Alex J. Brankiewicz, Richard H. Bunge, James C. French, Gerard C. Hokanson, Timothy R. Hurley, John P. Schaumberg
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Patent number: 4534970Abstract: This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.Type: GrantFiled: June 23, 1983Date of Patent: August 13, 1985Assignee: American Cyanamid CompanyInventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
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Patent number: 4533547Abstract: A novel antiviral antibiotic AM-2722 is described represented by the molecular formula C.sub.19 H.sub.26 NO.sub.3 Cl, and having the following physicochemical properties:(1) specific rotary power: [.alpha.].sub.D.sup.20 -0.5 (C-1, chloroform);(2) the UV spectrum shown in FIG. 1; and(3) the IR spectrum shown in FIG. 2.Also described is a process for producing the antiviral antibiotic AM-2722, wherein a microorganism of Streptomyces which has the ability to produce the antibiotic AM-2722 is cultured aerobically in a nutrient medium and the antibiotic AM-2722 accumulated in the medium and the microorganism cells is recovered.Type: GrantFiled: May 11, 1981Date of Patent: August 6, 1985Assignee: The Kitasato InstituteInventors: Satoshi Omura, Akira Nakagawa, Hiroshi Hashimoto, Yasuhiko Kojima, Yuzuru Iwai, Ruiko Oiwa, Atsushi Hirano
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Patent number: 4530835Abstract: A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors.Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds.The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.Type: GrantFiled: July 8, 1983Date of Patent: July 23, 1985Assignee: Warner-Lambert CompanyInventors: Richard H. Bunge, James C. French, Timothy R. Hurley, Tim A. Smitka, Josefino B. Tunac
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Patent number: 4526866Abstract: A novel enzyme inhibitor of angiotensin I-converting enzyme was produced from an actinomycetes belonging to genus Streptomyces. This enzyme inhibitor is a peptide, and specifically inhibits the angiotensin I-converting enzyme, but does not inhibit thermolycin, pepsin and .alpha.-chymotrypsin.Type: GrantFiled: April 5, 1983Date of Patent: July 2, 1985Assignee: Fujizoki Pharmaceutical Co., Ltd.Inventors: Yasuji Kido, Tsutomu Yoshida, Toshinari Hamakado, Masami Anno, Takahiro Harada, Yoshinobu Motoki
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Patent number: 4521408Abstract: The mixture, Antibiotics-859A and the production thereof is described. The Antibiotics-859A are produced by the controlled aerobic cultivation of Streptomyces griseoruber, ATCC 39068 in an aqueous nutrient medium. The Antibiotics-859A exhibit activity both in vitro and in vivo against gram negative and gram positive organisms including the genera: Diplococcus, Staphylococcus, Streptococcus, Pseudomonas and Salmonella.Type: GrantFiled: April 14, 1982Date of Patent: June 4, 1985Assignee: Merck & Co., Inc.Inventor: Edward O. Stapley
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Patent number: 4517178Abstract: This invention relates to a novel antibiotic 76-11; process for the production thereof which comprises culturing an antibiotic 76-11 producing microorganism belonging to the genus Actinomadura to separate and collect the antibiotic; an anticoccidiosis agent comprising the antibiotic as an effective ingredient; and a growth accelerating and feed efficiency increasing agent for domestic animals and fowls comprising the antibiotic as an effective ingredient.Type: GrantFiled: June 13, 1983Date of Patent: May 14, 1985Assignees: Rikagaku Kenkyusho, Kaken Kagaku Kabushiki KiashaInventors: Kiyoshi Isono, Goto Nakamura, Shigeo Fujita
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Patent number: 4512975Abstract: Macbecin derivatives are produced by cultivating a microorganism of the genus Actinosynnema in a culture medium.The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.Type: GrantFiled: September 14, 1983Date of Patent: April 23, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Toru Hasegawa, Masayuki Muroi, Seiichi Tanida
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Patent number: 4512976Abstract: This invention relates to the antibiotic stubomycin and process for producing same by culturing streptomyces sp KG - 2245 FERM-P No.Type: GrantFiled: September 25, 1981Date of Patent: April 23, 1985Assignee: The Kitasato InstituteInventors: Iwao Umezawa, Kanki Komiyama, Hideo Takeshima
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Patent number: 4511560Abstract: New substances designated as DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 and represented by the following general formula: ##STR1## wherein (i) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR2## and R.sub.3 represents ##STR3## (designated DC-45-A); (ii) R.sub.1 represents --OH, R.sub.2 represents --CH.sub.2 OH and R.sub.3 represents ##STR4## (designated DC-45-B.sub.1); or (iii) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR5## and R.sub.3 represents ##STR6## (designated DC-45-B.sub.2). DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 possess antibiotic and anti-tumor activity and may be obtained by culturing a microorganism of the genus Streptomyces. Preferred strain is Streptomyces bottropensis (FERM-P No. 5219; NRRL 12051).Type: GrantFiled: August 30, 1982Date of Patent: April 16, 1985Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Fusao Tomita, Tatsuya Tamaoki, Kunikatsu Shirahata, Takao Iida, Makoto Morimoto, Kazuhisa Fujimoto
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Patent number: 4505895Abstract: Novel and useful antibiotics designated 273a.sub.1.spsb..alpha. and 273a.sub.1.spsb..beta. can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacteria. Also, these antibiotics are, advantageously, soluble in aqueous solutions.Type: GrantFiled: March 30, 1983Date of Patent: March 19, 1985Assignee: The Upjohn CompanyInventors: Alexander D. Argoudelis, Vincent P. Marshall, Paul F. Wiley
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Patent number: 4503152Abstract: An antibiotic substance designated as AM-2604-A is described, and is obtained by cultivating an antibiotic AM-2604-A substance-producing strain belonging to the genus Streptomyces in a nutrient medium and recovering the desired substance from the culture broth.Type: GrantFiled: January 21, 1983Date of Patent: March 5, 1985Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hideki Shimizu
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Patent number: 4499075Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.Type: GrantFiled: March 25, 1982Date of Patent: February 12, 1985Assignee: American Cyanamid CompanyInventors: May D. Lee, John H. Martin, Donald B. Borders, Raymond C. Yao, Raymond T. Testa
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Patent number: 4497797Abstract: .beta.-Galactosidase inhibitors GT-2558, GT-2558-A, and GT-2558-B produced by a strain Streptomyces lydicus PA-5726, and their derivatives, acetyl-GT-2558-A and acetyl-GT-2558-B, useful as diagnostatic aid in .beta.-galactosidase deficiency, used in purification of enzymes, in research of new .beta.-galactosidase, in controlling sweetness of lactose-containing foods and in fermentation industry.Type: GrantFiled: June 29, 1982Date of Patent: February 5, 1985Assignee: Shionogi & Co., Ltd.Inventors: Mitsuo Ebata, Yukio Miyake, Yoshimi Kawamura
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Patent number: 4487762Abstract: New antibiotic 5057B and process for its preparation. Antibiotic 5057B itself is an acidic material, and its sodium salt has the following physical and chemical properties:(1) Colorless needles(2) Melting point: 143.degree.-145.degree. C.(3) Elementary analysis (Found %): C, 59.96; H, 9.03; O, 27.60; Na, 3.41(4) Specific rotation: [.alpha.].sub.D.sup.25 =+5.5.degree. (C 1, CHCl.sub.3)(5) Maximum absorption in ultraviolet absorption spectrum: .lambda..sub.max.sup.MeOH (E.sub.1 cm.sup.1%) 290 nm (0.88)(6) Characteristic absorption (cm.sup.-1) in infrared absorption spectrum (taken with the potassium bromide tablet: 3480, 3000, 2970, 2812, 1719, 1645, 1595, 1465, 1385, 1160, 1100, 1035, 980(7) Solubility: soluble in methanol, ethanol, ethyl acetate, chloroform, ether, acetone, and benzene and so forth; insoluble in water(8) Color reaction: positive in the 2,4-dinitrophenylhydrazine reaction; negative in the ninhydrin reaction and the vanilline-sulfuric acid reaction; colors with I.sub.2 gas.Type: GrantFiled: July 13, 1982Date of Patent: December 11, 1984Assignee: Kaken Chemical Co. Ltd.Inventors: Kusakabe Yoko, Mizuno Taku
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Patent number: 4476111Abstract: A new antibiotic, designated S/433, is disclosed which is produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces. This new antibiotic is active against gram-positive and gram-negative bacteria and is also active in inhibiting the growth of transplanted tumors.Type: GrantFiled: October 19, 1981Date of Patent: October 9, 1984Assignee: Gruppo Lepetit S.p.A.Inventors: Carolina Coronelli, Angelo Borghi, Giorgio Pirali, Giovanni Mistrello
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Patent number: 4454228Abstract: Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.Type: GrantFiled: September 29, 1982Date of Patent: June 12, 1984Assignee: The Upjohn CompanyInventors: Howard A. Whaley, William C. Snyder, John C. Greenfield, John H. Coats
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Patent number: 4427776Abstract: Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.Type: GrantFiled: September 21, 1981Date of Patent: January 24, 1984Assignee: The Upjohn CompanyInventors: Howard A. Whaley, William C. Snyder, John C. Greenfield, John H. Coats
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Patent number: 4427656Abstract: The present invention refers to a chlorine containing antibiotic substance, named antibiotic A/16686 factor A.sub.2, in an essentially pure form. The invention also relates to the process for the production of antibiotic A/16686 factors A.sub.2 by cultivation of an Actinoplanes strain and to the co-produced antibiotic A/16686 factos A.sub.1 and A.sub.3. Antibiotic A/16686 factors A.sub.1, A.sub.2 and A.sub.3 as well as the corresponding non-toxic physiologically acceptable acid addition salts are antimicrobial agents particularly active against gram-positive bacteria.Type: GrantFiled: July 31, 1981Date of Patent: January 24, 1984Assignee: Gruppo Lepetit S.p.A.Inventors: Bruno Cavalleri, Enrico Selva
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Patent number: 4427655Abstract: The Antibiotics-875A are obtained from the controlled aerobic cultivation of Streptomyces hygroscopicus ATCC 39067. The Antibiotics-875A show in vitro and in vivo activity against gram positive and gram negative organisms including the genera; Staphylococcus, Streptococcus, Aerobacter, Escherichia, Klebsiella, Parlacolobactrum, Pseudomonas and Salmonella.Type: GrantFiled: April 12, 1982Date of Patent: January 24, 1984Assignee: Merck & Co., Inc.Inventor: Edward O. Stapley
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Patent number: 4420473Abstract: New antibiotic designated MF266 substance is now obtained from fermentaton of a new microorganism Streptomyces MF266-g4 (desposited under FERM-P 5401 or ATCC 31910). This new substance is useful as antibacterial agent and/or an antitumor agent for the inhibition of experimental animal tumors.Type: GrantFiled: August 27, 1981Date of Patent: December 13, 1983Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Masa Hamada, Shinichi Kondo, Kiyoto Ishii
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Patent number: 4404190Abstract: Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.Type: GrantFiled: January 22, 1982Date of Patent: September 13, 1983Assignee: The Upjohn CompanyInventors: Lester A. Dolak, Fritz Reusser, Thomas M. Castle, Betty R. Hannon, Alice L. Laborde, Charles K. Marschke
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Patent number: 4385122Abstract: A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.Type: GrantFiled: August 21, 1981Date of Patent: May 24, 1983Assignee: SmithKline Beckman CorporationInventors: Claude H. Nash, III, Marcia C. Shearer, Kenneth M. Snader, Joseph R. Valenta, David Cooper
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Patent number: 4375511Abstract: The present invention relates to a process for producing aclacinomycins A and B. More particularly, the present invention is concerned with a process for producing selectively aclacinomycins A and B in high yield without formation of cinerubins A and B, by means of a fermentation process, utilizing Streptomyces galilaeus OBB-731.Type: GrantFiled: October 22, 1981Date of Patent: March 1, 1983Assignee: Hoffmann-La Roche Inc.Inventors: Akiko Fujiwara, Tatsuo Hoshino, Masaaki Tazoe
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Patent number: 4375513Abstract: Antibiotic A-4696 factors B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.3, and E.sub.1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p.sup.H 10.5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.Type: GrantFiled: October 9, 1981Date of Patent: March 1, 1983Assignee: Eli Lilly and CompanyInventors: Manuel Debono, Kurt E. Merkel, Robert E. Weeks, Herald J. Cole
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Patent number: 4375464Abstract: Antibiotic AY24,668 is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. AY24,668 has antifungal properties. Methods for its preparation and use are disclosed.Type: GrantFiled: November 19, 1981Date of Patent: March 1, 1983Assignee: Ayerst, McKenna & Harrison Inc.Inventors: Surendra N. Sehgal, Claude Vezina
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Patent number: 4372947Abstract: Antibiotic substance named saframycin S having antibacterial activities and produced by decyanating antibiotic saframycin A or cultivating Streptomyces lavendulae strain No. 314 and recovering saframycin S from a cultured broth.Type: GrantFiled: September 23, 1980Date of Patent: February 8, 1983Assignee: Tadashi AraiInventors: Tadashi Arai, Katsuhiro Takahashi, Kimiko Ishiguro, Koji Yokoyama