Metabolism Of Micro-organism Enhanced (e.g., Growth Enhancement Or Increased Production Of Microbial Product) Patents (Class 435/173.8)
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Publication number: 20080215116Abstract: Methods and devices are described for the regulation of Fibroblastic Growth Factor-2 mRNA and/or FGF-2 protein in bone cells and other tissues via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues, where the specific and selective fields are generated by application of specific and selective signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein.Type: ApplicationFiled: February 8, 2008Publication date: September 4, 2008Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: Carl T. Brighton
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Publication number: 20080145906Abstract: Methods for increasing lipolysis in a cell are described herein. Such methods comprise the application of an electrical current to a cell. In an embodiment, the application of the electrical current does not substantially alter the viability of such cell and/or preserves the viability of such cell. In an embodiment, such cell is an adipocyte. Corresponding uses and packages are also described.Type: ApplicationFiled: June 7, 2006Publication date: June 19, 2008Applicant: TRANSFERT PLUS S.E.C.Inventors: Jean P. Boucher, Roland Savard, Michel Portmann, Zied Haj Hamida
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Patent number: 7374916Abstract: Methods and devices for the regulation of aggrecan gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for aggrecan gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate aggrecan gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.Type: GrantFiled: September 26, 2002Date of Patent: May 20, 2008Assignee: The Trustees Of The University of PennsylvaniaInventor: Carl T. Brighton
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Patent number: 7354748Abstract: A method for applying therapeutic electrical signals and/or electromagnetic fields to a patient's knee for the treatment of osteoarthritis and other diseases, defects and injuries. The device that is used is operable in several modes to deliver signals to the patients knee so as to cause an electric and/or electromagnetic field to be generated that selectively up-regulates gene expression of Aggrecan and Type II Collagen while simultaneously selectively down-regulating the gene expression of metalloproteases. The device includes a signal generator that generates compound electric signals including a 60 kHz sine wave having a peak to peak voltage of approximately 4.6 V to 7.6 V and a 100% duty cycle signal that is generated for approximately 30 minutes and a 50% duty cycle signal that is generated for approximately 1 hour after the 100% duty cycle signal.Type: GrantFiled: May 9, 2005Date of Patent: April 8, 2008Assignee: The Trustees of The University of PennsylvaniaInventor: Carl T. Brighton
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Patent number: 7297522Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to treat epilepsy. Also included are methods of making such compositions and methods of treating epilepsy.Type: GrantFiled: November 18, 2003Date of Patent: November 20, 2007Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 7259001Abstract: The invention provides compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to increase secretion of male hormones or alleviate or prevent sexual disorders, e.g., impotence, in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also provided are methods of making and using these compositions.Type: GrantFiled: November 18, 2003Date of Patent: August 21, 2007Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 7125695Abstract: The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.Type: GrantFiled: November 20, 2003Date of Patent: October 24, 2006Assignee: Genencor International, Inc.Inventors: Volker Schellenberger, Amy D. Liu, Olga V. Selifonova
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Patent number: 7078202Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to treat vascular dementia in a mammal. Also included are methods of making such compositions and methods of treating vascular dementia.Type: GrantFiled: November 18, 2003Date of Patent: July 18, 2006Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 7022506Abstract: A method of determining the voltage and current output required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffolds, growth factors, etc.) for treating cartilage defects in the human knee joint and a device for delivering such signals to a patient's knee. An analytical model of the human knee is developed whereby the total tissue volume in the human knee may be determined for comparison to the total tissue volume of the diseased tissue in the animal model using electric field and current density histograms.Type: GrantFiled: June 9, 2003Date of Patent: April 4, 2006Assignee: The Trustees of the University of PennsylvaniaInventors: Carl T. Brighton, Solomon R. Pollack
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Patent number: 6994850Abstract: The present invention provides a method for preparing a biological fertilizer composition that comprises yeast cells and swine manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor.Type: GrantFiled: July 22, 2003Date of Patent: February 7, 2006Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6979444Abstract: The present invention provides a method for preparing a biological fertilizer composition that comprises yeast cells and poultry manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor.Type: GrantFiled: July 22, 2003Date of Patent: December 27, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6979562Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat gastroparesis in a subject (e.g., stimulating stomach contraction, reducing abnormal gastric acid and/or pepsin production), as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.Type: GrantFiled: November 18, 2003Date of Patent: December 27, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6977168Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat nephrotic syndrome (e.g., lower urinary protein and increase serum protein) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.Type: GrantFiled: November 18, 2003Date of Patent: December 20, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6964864Abstract: The invention provides compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to ameliorate or prevent gastritis in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also provided are methods of making and using these compositions.Type: GrantFiled: November 18, 2003Date of Patent: November 15, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6955886Abstract: The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan synthesis.Type: GrantFiled: May 4, 1999Date of Patent: October 18, 2005Assignee: AstraZeneca ABInventors: Sunita Desousa, Dwarakanath Prahlad
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Patent number: 6951756Abstract: The invention relates to a method for preparing closed bacterial ghosts by means of vesicle membrane fusion and to the bacterial ghosts which can be obtained in this way. Active compounds, e.g. genetic material, cell components, pharmaceutical and agricultural active compounds and also markers or dyes can be packaged in the closed bacterial ghosts. Metabolic functions and, where appropriate, the ability of the cells to proliferate can be restored on packaging genetic material in the bacterial ghosts. The closed ghosts can be used in medicine, in the agricultural sphere and in biotechnology.Type: GrantFiled: January 26, 2001Date of Patent: October 4, 2005Inventors: Werner Lubitz, Susanne Paukner
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Patent number: 6919205Abstract: Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate specific and selective fields optimized for type II collagen gene expression and exposing cartilage tissue to the specific and selective fields generated by specific and selective signals so as to regulate type II collagen gene expression in such cartilage tissue.Type: GrantFiled: October 9, 2002Date of Patent: July 19, 2005Assignee: The Trustees of the University of PennsylvaniaInventor: Carl T. Brighton
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Patent number: 6913914Abstract: The invention provides compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to normalize the level of serum glutamate-pyruvate Transaminase (GPT), or reduce serum HBsAg levels in a subject, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also provided are methods of making and using these compositions.Type: GrantFiled: November 18, 2003Date of Patent: July 5, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6913913Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to ameliorate renal failure (e.g., improved diuretic effect and/or lowering blood urea nitrogen, proteinuria, and/or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.Type: GrantFiled: November 18, 2003Date of Patent: July 5, 2005Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6855513Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.Type: GrantFiled: September 1, 2000Date of Patent: February 15, 2005Assignees: University of Iowa Research Foundation, Vertex Pharmaceuticals (San Diego) LLCInventors: Marvin Whiteley, Kimberly M. Lee, E. Peter Greenberg, Ute Muh
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Patent number: 6846667Abstract: The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The identification of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.Type: GrantFiled: November 9, 1999Date of Patent: January 25, 2005Assignee: Microscience, Ltd.Inventors: Helen Rachel Crooke, Enda Elizabeth Clarke, Paul Howard Everest, Gordon Dougan, David William Holden, Jacqueline Elizabeth Shea, Robert Graham Feldman
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Patent number: 6828132Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells and garbage. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing biological fertilizer compositions, and methods of uses are also encompassed.Type: GrantFiled: July 9, 2002Date of Patent: December 7, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6828131Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells that have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, over produce growth factors, and over produce ATP. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing the biological fertilizer compositions and methods of uses are also encompassed.Type: GrantFiled: July 9, 2002Date of Patent: December 7, 2004Assignee: Ultra Biotech LimitedInventor: Lingyu Zhang
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Patent number: 6800466Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells and sludge. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing biological fertilizer compositions, and methods of uses are also encompassed.Type: GrantFiled: March 1, 2001Date of Patent: October 5, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6793933Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to enhance the immune system (e.g., increase the activity of T and B lymphocytes and natural killer cells) in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.Type: GrantFiled: June 28, 2002Date of Patent: September 21, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6770464Abstract: The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.Type: GrantFiled: February 8, 2001Date of Patent: August 3, 2004Assignee: Metabolix, Inc.Inventors: Alexander Steinbüchel, Mathias Liebergesell, Henry Valentin, Andreas Pries
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Patent number: 6761886Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells and cattle manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing biological fertilizer compositions, and methods of uses are also encompassed.Type: GrantFiled: March 1, 2001Date of Patent: July 13, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6759055Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to improve kidney functions (e.g., restoring urine secretion and/or lowering blood urea nitrogen, serum proteinuria, and/or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.Type: GrantFiled: June 28, 2002Date of Patent: July 6, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6756050Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to improve the memory of a mammal. Also included are methods of making such compositions.Type: GrantFiled: June 28, 2002Date of Patent: June 29, 2004Assignee: Ultra Biotech LimitedInventor: Larry Ling Yuk Cheung
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Patent number: 6753008Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to normalize the serum level of GPT, AP and/or LDH-5 in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.Type: GrantFiled: June 28, 2002Date of Patent: June 22, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6709849Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat male hormone deficiency in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.Type: GrantFiled: June 28, 2002Date of Patent: March 23, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6706503Abstract: The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.Type: GrantFiled: October 23, 2001Date of Patent: March 16, 2004Assignee: Genencor International, Inc.Inventors: Volker Schellenberger, Amy D. Liu, Olga V. Selifonova
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Publication number: 20040014199Abstract: Methods and apparatus for preserving tissue such as harvested organs for transplant are described. A preferred method includes delivering to a harvested organ an effective amount of electromagnetic energy, the electromagnetic energy having a wavelength in the visible to near-infrared wavelength range, wherein delivering the effective amount of electromagnetic energy includes selecting a predetermined power density (mW/cm2) of electromagnetic energy to deliver to the organ while in hypothermic or normothermic storage. A preferred apparatus includes a container having a cooling chamber to receive the harvested organ and at least one light source mounted on the container to illuminate the interior cooling chamber, said light source emiting light which produces a biostimulative effect on tissue placed in the cooling chamber thereby preventing or retarding damage to the tissue during storage or transport.Type: ApplicationFiled: January 8, 2003Publication date: January 22, 2004Inventor: Jackson Streeter
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Publication number: 20040005680Abstract: The present invention relates to health food, health drink, and health supplement. The invention relates to biological compositions comprising yeast cells that can improve the immune functions of animals. The invention also relates to methods for manufacturing the biological compositions, and methods of using the biological compositions to produce a healthful benefit in a subject with immunodeficiency disorders or immunosuppression by promoting activation and proliferation of white blood cells.Type: ApplicationFiled: June 28, 2002Publication date: January 8, 2004Inventor: Ling Yuk Cheung
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Publication number: 20040001815Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat male hormone deficiency in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.Type: ApplicationFiled: June 28, 2002Publication date: January 1, 2004Inventor: Ling Yuk Cheung
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Publication number: 20030232059Abstract: The present invention relates to feed additives for fishes in aquaculture. The invention provides methods for making a biological compositions comprising yeast cells that can improve the immune functions of fishes in culture. The invention also relates to methods for manufacturing the biological compositions, and methods of using the biological compositions as feed additives.Type: ApplicationFiled: June 18, 2002Publication date: December 18, 2003Inventor: Ling Yuk Cheung
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Patent number: 6665429Abstract: A method and associated apparatus for use in a microbiological assay procedure wherein a plurality of diffusion disks are placed on a nutrient medium on a plate, each of the disks carrying a respective antibiotic agent and each having an identification code identifying the respective antibiotic agent, the disks being positioned on the plate in a preselected relative arrangement. The method comprises optically scanning the disks on the plate, consequently generating a digitally encoded image including digitized representations of the identification codes, and electronically processing the digitally encoded image to determine an angle of rotation of the plate relative to a pre-established reference frame or coordinate system, wherein the electronic processing of the digitally encoded image includes detecting a region of the plate occupied by a unique subset of the disks.Type: GrantFiled: September 22, 2000Date of Patent: December 16, 2003Assignee: Giles Scientific, Inc.Inventor: Qi Wang
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Patent number: 6635457Abstract: This invention provides methods for producing and selecting host cells that better survive transformation treatment by subjecting host cells to conditions that alter them, subjecting the altered cells to transformation conditions, and selecting host cells that survive the transformation conditions. This invention also provides methods for transferring nucleic acids of interest into host cells, using cells that are better able to survive transformation treatment. Also, this invention provides kits for producing or selecting host cells in transformation treatments, as well as, kits comprising various host cells that may be utilized in transformation experiments.Type: GrantFiled: July 26, 2000Date of Patent: October 21, 2003Assignee: StratageneInventor: Alan L. Greener
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Publication number: 20030180800Abstract: The metabolic processes involved in the formation of any glucose-based metabolite are determined. A precursor molecule is labeled with a stable carbon (13C) isotope at specific positions. The label is allowed to distribute and rearrange in the system. Metabolites are recovered and analyzed against a control system to determine metabolic pathway substrate flux caused by changes to the test system relative to the control system such as the addition of compound being tested as a potential drug.Type: ApplicationFiled: July 9, 2002Publication date: September 25, 2003Inventors: Wai-Nang Paul Lee, Laszlo G. Boros
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Publication number: 20030138922Abstract: A method of causing irreversible damage to stealth virus infected cells, based on exposing the infected cells to magnetic energy. The method of the present application specifically relates to the culturing of stealth viruses from an infected subject and determining the presence of magnetic and/or paramagnetic material in the stealth virus infected culture. Magnetic and/or paramagnetic material can also be found in cultures of bacteria that are infected with the patient's stealth virus. The cultured stealth virus infected cells are tested for susceptibility to cell damage caused by a magnetic field that is not significantly injurious to normal uninfected cells. The presence of magnetic and/or paramagnetic material in the stealth virus culture and the demonstration that exposure to a strong magnetic field can cause damage to stealth virus infected cells, form the basis of therapy for stealth virus infected patients and animals.Type: ApplicationFiled: January 24, 2002Publication date: July 24, 2003Inventor: William John Martin
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Patent number: 6596272Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells and poultry manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing biological fertilizer compositions, and methods of uses are also encompassed.Type: GrantFiled: March 1, 2001Date of Patent: July 22, 2003Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6596273Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells and swine manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing biological fertilizer compositions, and methods of uses are also encompassed.Type: GrantFiled: March 1, 2001Date of Patent: July 22, 2003Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6569654Abstract: Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling.Type: GrantFiled: January 2, 2001Date of Patent: May 27, 2003Assignee: Massachusetts Institute of TechnologyInventors: Venkatram Shastri, Ivan Martin, Robert Langer, Nahid Rahman
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Publication number: 20030064487Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells that have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, over produce growth factors, and over produce ATP. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing the biological fertilizer compositions and methods of uses are also encompassed.Type: ApplicationFiled: July 9, 2002Publication date: April 3, 2003Applicant: Ultra Biotech LimitedInventor: Lingyu Zhang
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Patent number: 6524842Abstract: A method for degrading an undesirable ether-based environmental contaminant by contacting the ether with a hydrogen-oxidizing microorganism to convert the ether to innocuous compounds which are environmentally acceptable, including treating the ether-based contaminants in situ or removing them from the contaminated site for treatment in a bioreactor, examples of the ether-based contaminants being tertiary butyl ethers of the type utilized as gasoline oxygenates, for example, methyl tert-butyl ether, ethyl tert-butyl ether, and methyl tert-amyl ether, and also ether solvents, for example, tetrahydrofuran.Type: GrantFiled: June 30, 2000Date of Patent: February 25, 2003Assignee: Envirogen, Inc.Inventors: Simon Vainberg, Robert J. Steffan
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Patent number: 6492149Abstract: The invention relates to a method of improving the yield of a photobioreactor of the continuously operating recirculation type as a function of the species of micro-organism being cultured, of the thickness d of the chambers (10) of the reactor, and of the final concentration desired for the culture. In the method, transparent or respecting particles (15) are introduced into the reaction medium (11), which particles are of a density that is substantially equal to that of the reaction medium, thereby adjusting absorbance of the microorganism culture to optimum levels. The invention is mainly applicable to culturing phototropic micro-organisms.Type: GrantFiled: April 17, 2001Date of Patent: December 10, 2002Assignee: Institut Francais de Recherche pour l'Exploitation de la MerInventor: Arnaud Muller-Feuga
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Publication number: 20020164780Abstract: In the micro organism cultivation device of this invention, an implantable bio-artificial micro device, i.e., a cell apartment, is provided to cultivate cells or tissues. The cells or tissues to be cultivated include that secrete hormones such as islets of Langerhans. At both sides of the cell apartment, provided are microfluidic channels comprising dynamic micro-electric field array filters. The dynamic micro-electric field array filters comprise a plurality of electrodes distributed inside the microchannels. By periodically switching the polarity of the electrodes, microfluidic flows are generated in the microchannels. All inlet flows to the cell apartment are filtered by the immunoisolation of the micro-electric field array filters before entering into the cell apartment. The micro-electric field array filters provide a physical immune protection to the cells cultivated in the cell apartment against the immune system of the host.Type: ApplicationFiled: March 2, 2001Publication date: November 7, 2002Inventors: Nan-Kuang Yao, Kuo-Yao Weng
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Patent number: 6436695Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to substantially increase the capability of said plurality of yeast cells to convert biologically available phosphorus in a culture medium into their own biomass. Also included are methods of making such compositions.Type: GrantFiled: March 1, 2001Date of Patent: August 20, 2002Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6416982Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells that have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, over produce growth factors, and over produce ATP. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing the biological fertilizer compositions and methods of uses are also encompassed.Type: GrantFiled: September 5, 2000Date of Patent: July 9, 2002Assignee: Ultra Biotech Ltd.Inventor: Lingyu Zhang
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Patent number: 6416983Abstract: The present invention provides biological fertilizer compositions that comprise yeast cells and garbage. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon compounds, overproduce growth factors, overproduce ATP, decompose undesirable chemicals, suppress growth of pathogenic microorganisms, or reduce undesirable odor. The biological fertilizer composition of the invention can replace mineral fertilizers in supplying nitrogen, phosphorus, and potassium to crop plants. Methods of manufacturing biological fertilizer compositions, and methods of uses are also encompassed.Type: GrantFiled: March 1, 2001Date of Patent: July 9, 2002Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung