Inoculator, Streaker, Or Sampler Patents (Class 435/309.1)
  • Patent number: 11931013
    Abstract: A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: March 19, 2024
    Inventors: Philippe Cinquin, Denis Favier, Thierry Alonso, Aziz Bakri, Nawel Khalef, Jacques Thelu, Sylvain Besson, Donald Martin
  • Patent number: 11911763
    Abstract: This disclosure provides devices and methods for the isolation of single cells or particles of interest from a solution comprising a plurality of cells or a solution composed of a homogenous population of particles. Specifically, the present disclosure is directed to microfluidic devices and methods for analyzing cells in a sample. More specifically, the present disclosure provides droplet microfluidic devices and methods for using the same to obtain (trap), encapsulate, and retrieve (isolate) single cells or particles from a sample with improved efficiency.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: February 27, 2024
    Inventors: Eric Brouzes, Martin Sauzade
  • Patent number: 11808673
    Abstract: Disclosed are apparatus and methods for sampling air-borne particles. According to one embodiment a nozzle is used to generate a jet of fog that includes a gas and liquid droplets of different sizes. The jet of fog is formed by the nozzle in a way to cause particles in the air surrounding the jet of fog to be drawn into the jet of fog and to further cause the particles to aggregate with the liquid droplets inside the jet of fog. A sample collecting surface is located opposite and spaced apart from an outlet of the nozzle. The sample collecting surface is preferably sloped so that the liquid sample can be forced by gravity off the collecting surface and into a vial or other liquid sample container. Inside the jet of fog and on the sample collection surface the liquid droplets merge with one another to form larger sized droplets that are collectable in the liquid sample container.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: November 7, 2023
    Inventors: José Luis Pérez Díaz, Antonio Alcamí Pertejo
  • Patent number: 11801511
    Abstract: Provided herein is technology relating to collecting and containing samples and particularly, but not exclusively, to technology for collecting and containing a stool specimen. The technology provides a device for collecting and containing a stool specimen, the device comprising ergonomic features optimized for a geriatric user. The technology also provides an enclosing holder for securing the ergonomic stool specimen container in a leak-proof manner e.g., during mechanical shaking.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: October 31, 2023
    Assignee: Exact Sciences Corporation
    Inventors: Joseph E. Schiestle, Krystal A. Burger, Timothy A. Parmer, Jad A. Lunde, Sam M. Jang, David A. Schuelke, David B. Wolgemuth, Jing Yang Lu
  • Patent number: 11560305
    Abstract: Function fabrication in a microfluidic device manufactured with a custom 3D printer. The functions may include, for example, transporting or routing fluid, fluid mixing through flow and/or diffusion, blocking fluid (valve), pumping fluid, providing chemical reaction regions, providing analyte capture regions, and providing analyte separation regions. The fluid may be a liquid or a gas.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: January 24, 2023
    Inventors: Gregory Nordin, Adam Woolley, Hua Gong, Jose Sanchez Noriega, Anna Virginia Bickham
  • Patent number: 11364452
    Abstract: Provided is an extraction method for extracting an extract from a mixture using liquefied gas that can dissolve the extract, the method facilitating extraction operations and enabling low cost operation. An extraction device that extracts a component dissolved in liquefied gas from material to be treated using continuous phase changes in the liquefied gas is characterized by being provided with: a compressor that feeds gas under pressure; a heat exchanger for generating liquefied gas by the gas flowing in a high temperature side flow path; a treatment tank into which the material to be treated is loaded and the liquefied gas flows; and a retention tank provided in series or in parallel to the flow path downstream of the high temperature side flow path in the heat exchanger.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 21, 2022
    Assignee: HITACHI, LTD.
    Inventors: Tadashi Sano, Toom Miyasaka, Sachio Sekiya
  • Patent number: 11353379
    Abstract: A sampling apparatus (100) employs a cell-positioning system to move a sample capture cell (138) relative to a specimen positioning system (124). The cell-positioning system may be controlled to move sample capture cell (138) opposite to movement of the specimen positioning system (124) to maintain alignment of the sample capture cell (138) with an optical path of a laser beam of a sample generator (108). Alternatively or additionally, the cell-positioning system may be controlled to move sample capture cell (138) in response to alignment deviation of a reference beam on a quadrant detector (404).
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: June 7, 2022
    Assignee: Elemental Scientific Lasers, Inc.
    Inventors: Shane Robert Hilliard, Leif Christian Summerfield, Erik Barnholt Larsen
  • Patent number: 11346753
    Abstract: There is provided a kit of parts for assembly into an impactor (100) for aerosol component collection, such as for exhaled breath. The kit of parts is configured such that an impactor component (128) is receivable into the assembly such that, when a sealing component (136) is in a sample collection configuration and an aerosol sample is being received at an aerosol inlet (110) of a housing of the kit, in use, an aerosol flow path (124) of the aerosol sample is directed onto an impaction surface (130) of the impactor component (128) to promote aerosol deposition thereon. The kit of parts is further configured such that the sealing component (136) is changeable in the assembly into a sample containment configuration before removal of the impactor component (128) from the assembly, so as to retain any aerosol components deposited on the impaction surface (130).
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: May 31, 2022
    Assignee: University of Northumbria at Newcastle
    Inventors: Volkan Turgul, Sterghios Moschos, Izzet Kale
  • Patent number: 11099116
    Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: August 24, 2021
    Inventor: Alexandre Loboda
  • Patent number: 10948386
    Abstract: Swabs, materials and methods of making the same include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. According to certain embodiments, swabs are provide which include an applicator, and sea-island bicomponent fibers attached to the applicator, wherein at least about 70% of the fibers comprise randomly splayed terminal ends of the islands of said bicomponent fibers along a length of about 45% or less from said ends, and wherein the bicomponent fibers comprise 10-3000 island parts per fiber.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 16, 2021
    Inventors: Terry Young, Timothy Templet, Paul Dube, Todd Dixon, Armand F. Lewis, Yong K. Kim
  • Patent number: 10948385
    Abstract: Swabs, materials, and methods of making same, include randomly arranged sea-island bicomponent fibers. According to certain embodiments, swabs and methods of using such swabs are provided so as to collect and release a biological sample comprising a flock fiber tipped applicator wherein the flock fibers are sea-island bicomponent fibers attached to an end portion of the applicator with an adhesive selected from the group consisting of a photocurable acrylic adhesive and a polyurethane adhesive, the bicomponent fibers being structurally stable in water and the sea component of the bicomponent flock fibers being intact.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 16, 2021
    Inventors: Terry Young, Timothy Templet, Paul Dube, Todd Dixon, Armand F. Lewis, Yong K. Kim
  • Patent number: 10746636
    Abstract: Disclosed is a device for preparing a layer of biological cells on a deposition surface of a slide, the device including a body provided with a channel, the body including a first end forming an inlet tip intended to enter inside a container containing a biological liquid, closed by a cap and a second end forming a depositing tip intended to deposit a drop of the liquid on the deposition surface, the second end including a spreader with a blade arranged in a plane forming an angle of inclination ? with the plane of the deposition surface and elastic return interposed between the blade and the second end.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 18, 2020
    Assignee: R.A.L. DIAGNOSTICS
    Inventor: Roger Lucien Marie Le Comte
  • Patent number: 10619152
    Abstract: Disclosed is a process for isolating cell-free nucleic acid (including both DNA and RNA) or an analog thereof from a bodily fluid, and which entails: a) mixing in a container the bodily fluid, a chaotropic agent in solid form, a detergent and a buffer, and a solid phase which includes magnetic particles, thus forming a reaction mixture containing the cell-free nucleic acid; b) magnetically separating the solid phase having the cell-free nucleic acid bound thereto from the reaction mixture; and optionally c) dissociating the nucleic acid from the solid phase. Compositions and kits are also disclosed.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: April 14, 2020
    Inventor: Nancy Quan
  • Patent number: 10617799
    Abstract: A removable manifold for a medical/surgical waste collection system. The manifold is dimensioned to be mounted to a receiver integral with the system. The manifold includes at least one tube through which waste is drawn into a manifold cage. The tube extends through an inlet port into a void space internal to the manifold cage at an angle. The tube exits the manifold cage and centered along an axis that is off center to the longitudinal axis of the manifold cage where it engages a complementary valve internal to the receiver. The valve regulates flow between the receiver and the down line components of the waste collection system. The valve is normally closed. When the manifold is fitted to the receiver the tube engages the valve and rotation of the manifold moves the valve to the open position allowing fluid flow from the manifold and receiver to the downstream components of the system.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: April 14, 2020
    Assignee: Medline Industries, Inc.
    Inventors: Andrew Mills, David Noskowicz, Brian Barkeley, Zachary Zott, Stuart Mintz
  • Patent number: 10363557
    Abstract: An apparatus for processing a biological sample is provided. The apparatus has a body having a processing chamber, a first reservoir, a second reservoir, a filter, a first one-way valve, a second one-way valve, a third one-way valve, a first fluid pathway, a second fluid pathway, and a third fluid pathway.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 30, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Jon A. Kirschhoffer, Gregory W. Sitton, Andrew H. Tilstra
  • Patent number: 10149666
    Abstract: In an embodiment of the invention, a frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain tissue biopsy samples. A frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device is narrow and pointed with a hybrid pear shaped diamond facet. The facet contour can be concave, convex or flat. Abrasive material can be adhered to the facet contour.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: December 11, 2018
    Inventor: Neal Marc Lonky
  • Patent number: 10024848
    Abstract: A flow channel device includes a flow channel section and an introduction channel section. The flow channel section includes a flow channel in which a detection object flows and a wall surface surrounding the flow channel. The introduction channel section includes an introduction channel having a first end connected to the flow channel and a second end connected to an introduction port, and a wall surface surrounding the introduction channel. At least a part of the wall surface surrounding the introduction channel is a curved surface protruding toward the introduction channel.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 17, 2018
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Akihiko Takada, Kiyoshi Hashimotodani, Yusuke Kitagawa
  • Patent number: 9709613
    Abstract: The present invention relates to a method and apparatus intended for the detection of low frequency electric waves that can be extracted from water, organic liquids and biological matter. This field phenomenon, that we here refer to here as a “bioharmonic”, is an active frequency, or harmonically related series of frequencies, that are a result of a dynamic interplay of natural processes including physical, chemical and electromagnetic interactions. We have discovered that these interactions influence the organization of signal waveform characteristics at very low frequencies. The apparatus produces a low frequency electrical wave that is coupled to a liquid or solid sample by way of a coupling electrode having a very high impedance. As the detected signal also displays field properties, the electrode does not need to be in contact with the sample in order to extract a unique signal.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: July 18, 2017
    Assignee: Association Promethora
    Inventor: Pier Rubesa
  • Patent number: 9689780
    Abstract: A single-use coring probe for collecting a frozen aliquot from a frozen biological sample includes a hollow coring bit and an ejector adapted. The ejector is operable to eject a frozen sample core from the bit as it moves from a retracted position to an extended position. Use of the ejector converts the probe to a disabled configuration to discourage reuse of the coring probe to obtain another sample. The probe may include a locking mechanism adapted to prevent re-use of the single-use coring probe by locking the ejector in the extended position. A hand-held coring device can be used to take frozen sample cores from frozen samples. A tissue container is suitable for holding a frozen tissue sample in frozen storage and also for holding the sample while the sample is sectioned and/or a full-depth frozen sample core is extracted from the frozen tissue.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: June 27, 2017
    Inventors: Larry Chin, Todd Basque
  • Patent number: 9212975
    Abstract: A collection unit (80)includes: a collection carrier cartridge (82) formed, at its center, with a through hole (82b3) into which a nozzle for supplying hot water or ATP reagent is inserted including a carrier filling dish (82b), on an outer circumference of the through hole (82b3), to be filled with a collection carrier (90) for collecting floating bacteria in the air, and an upper lid (82a) on which the carrier filling dish (82b) is placed, formed with a protrusion to be inserted through the through hole (82b3); an impactor nozzle head (86) covering a surface of the collection carrier (90) and has a plurality of nozzle holes (87) facing the collection carrier (90) surface; and a fan (84) introducing air to the collection carrier surface through the nozzle holes (87). A velocity of the air passing through the nozzle holes (87) is 40 m/s to 50 m/s.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: December 15, 2015
    Assignee: Hitachi, Ltd.
    Inventors: Noe Miyashita, Ryusuke Gotoda
  • Patent number: 9192932
    Abstract: In an aspect of this invention, a closure for a well plate is provided which has a reservoir. The closure has openings through which acoustic ejection of fluid droplets can take place without removing the closure. The reservoirs in the closure may help to maintain acceptable levels of solvent in the wells of the well plate despite the evaporation which may occur during the course of ejection.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 24, 2015
    Assignee: LABCYTE INC.
    Inventor: Richard N. Ellson
  • Publication number: 20150140601
    Abstract: A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde. The tissue sample (1) is left in the fixing reagent (2) for a fixing time period during which the fixing reagent (2) is brought to a second temperature level above the first temperature level and/or to a second pressure level above the first pressure level. A concentration in the fixing reagent (2) of the nitrogen-containing compound is ascertained using at least one concentration measuring device (14) of the tissue processor (10), and a signal is outputted on the basis of a measured value of the at least one concentration measuring device (14).
    Type: Application
    Filed: November 4, 2014
    Publication date: May 21, 2015
    Inventors: Hermann Ulbrich, Markus Berberich
  • Publication number: 20150140655
    Abstract: Various embodiments of methods and apparatuses for separating sperm, including apparatus having an inlet and an outlet reservoir, and either: i) a radial array of microchannels disposed between the inlet and outlet reservoirs to provide fluid communication therebetween and to direct motile sperm inwardly from the inlet reservoir to the outlet reservoir; or ii) at least one microchannel path disposed between the inlet and outlet reservoirs to provide fluid communication therebetween, the at least one microchannel path having a path inlet adjacent the inlet reservoir, a path outlet adjacent the outlet reservoir, and a junction located between the path inlet and the path outlet for directing a portion of sperm that enter the path inlet towards the outlet reservoir based on wall-swimming behaviour of sperm. Methods include filling an apparatus with buffer fluid, introducing semen into an inlet reservoir, and retrieving sperm separated from the semen from the outlet reservoir.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Inventors: Reza Nosrati, Lise Marie Eamer, Marion Vollmer, David Allan Sinton, Armand Zini
  • Publication number: 20150132746
    Abstract: Provided herein is technology relating to the collection of biological samples and particularly, but not exclusively, to compositions, methods, and uses related to using a biopolymer substrate to collect biological samples for analysis.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 14, 2015
    Inventors: Astrid Gjelstad, Lars Erik Eng Eibak, Anne Bee Hegge, Knut Einar Rasmussen, Stig Pedersen-Bjergaard
  • Publication number: 20150132755
    Abstract: An assembly for processing a sample is provided. The assembly comprises a first body having a plurality of spaced-apart conduits and a second body having a plurality of chambers wherein each conduit is fluidically connected to a separate chamber. The assembly forms a plurality of liquid flow paths, each flow path comprising a conduit and a chamber. An analyte capture element is detachably attached to a conduit and is in fluidic communication with the liquid flow path of the conduit. Optionally, the assembly further may comprise a third body comprising a plurality of reservoirs. The assembly can be used to process a liquid sample for detecting an analyte.
    Type: Application
    Filed: May 24, 2013
    Publication date: May 14, 2015
    Inventors: Jon A. Kirschhoffer, Andrew H. Tilstra, Wensheng Xia
  • Publication number: 20150118676
    Abstract: Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, an ionic propulsion device for providing a sample for a bio-specific assay of aerosol particles comprises a housing receiving a sample of aerosol particles and enclosing a high voltage electrode to generate a plasma of electrically charged particles. A carrier assembly is removably receivable in the housing, the carrier assembly comprising a non-conductive carrier and an electrode removably secured to the carrier.
    Type: Application
    Filed: August 22, 2014
    Publication date: April 30, 2015
    Inventor: Julian Gordon
  • Publication number: 20150118705
    Abstract: An apparatus and an assembly for processing a sample are provided. The apparatus comprises a plurality of spaced-apart reservoirs, a plurality of channels, and a plurality of outlets, each outlet comprising an effluent discharge opening. The apparatus forms a plurality of flow paths, each flow path comprising a reservoir, a channel, and an outlet. An analyte capture element can be slideably engaged in a channel in a position where it is in fluid communication with the flow path. The apparatus with the analyte capture element disposed in the flow path can be used to process a liquid sample. A method of detecting an analyte in the liquid sample is also provided.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 30, 2015
    Inventors: Jon A. Kirschhoffer, Andrew H. Tilstra, Wensheng Xia
  • Patent number: 9017617
    Abstract: Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: April 28, 2015
    Assignee: Luminex Corporation
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Publication number: 20150111295
    Abstract: The invention relates to an elutriation chamber for an elutriator system for washing and/or isolating cells, in particular thrombocytes, which elutriation chamber comprises a feed line (1) for an aqueous medium containing the cells to be washed and/or to be isolated in suspended form, and a discharge line (2) for the washed and/or isolated cells, wherein the chamber (5) is rotationally symmetrical to the axis (a), characterized in that the ratio of the area of the section through the lumen of the chamber (5) perpendicular to the axis (a) at the widest point (5a-5b) to the area of the section (1a) through the feed line (1) is in the range of 1,000 to 250,000.
    Type: Application
    Filed: May 13, 2013
    Publication date: April 23, 2015
    Inventors: Johann Eibl, Johann Graus, Christoph Mader
  • Publication number: 20150111293
    Abstract: Provided are a cancer cell-trapping metal filter which has a high opening ratio, a cancer cell-trapping metal filter sheet, a cancer cell-trapping device using the cancer cell-trapping filter, and manufacturing methods therefor. According to a cancer cell-trapping metal filter 1, openings of connected through-holes 12 that are formed in a metal sheet 11 have a wave shape, and thus it is possible to extract a CTC from other components by utilizing a hole diameter on a short-side side of the openings, and it is possible to make the connected through-holes be closer to each other due to the wave shape while maintaining a CTC trapping ability. Accordingly, it is possible to further improve the opening ratio in the cancer cell-trapping metal filter 1.
    Type: Application
    Filed: May 10, 2013
    Publication date: April 23, 2015
    Inventors: Hisashige Kanbara, Yoshihito Kikuhara, Takahiro Suzuki
  • Publication number: 20150111241
    Abstract: An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet.
    Type: Application
    Filed: April 17, 2013
    Publication date: April 23, 2015
    Inventors: Allison Hubel, Jacob Hanna
  • Publication number: 20150111242
    Abstract: The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device 100 that is operated by a pneumatic device 200. In one particular embodiment, apparatuses of the invention are used for collecting and transferring cell sample to and from cell collecting device 100.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 23, 2015
    Applicant: The Regents of the University of Colorodo, a body corporate
    Inventors: Wilbur Franklin, Aaron Lieberman, Mark Palmer, Willem Berglund, Stephen DeMars, Andrew Hanuszek, Dara Aisner, Qing Ren, Eric Kelso
  • Publication number: 20150104824
    Abstract: A separation device that can include a separation tube or container that has a wall defining an internal volume into which a material can be placed is disclosed. The material can include a multi-component mixture or solution. A secondary tube or withdrawal cannula can be placed and/or moved within the tube to withdrawal a material form the tube.
    Type: Application
    Filed: October 9, 2014
    Publication date: April 16, 2015
    Inventors: Trenton WALKER, Matthew D. Landrigan, Michael D. Leach, Scott R. King, Randel Dorian, Richard W. Storrs
  • Publication number: 20150105300
    Abstract: A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 16, 2015
    Inventors: Shuqi Chen, Lingjun Chen
  • Publication number: 20150104791
    Abstract: The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be separated, such that said particles are retained by the filter. The invention is characterised in that: (i) the method involves the use of a filter comprising at least one basic filtration zone, whereby each basic filtration zone has a limited surface area; and (ii) the surface area of each basic filtration zone and the number of basic filtration zones are selected as a function of the type of liquid to be filtered, the type of biological particles to be separated and the volume of liquid to be filtered.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 16, 2015
    Inventor: Patrizia PATERLINI-BRECHOT
  • Publication number: 20150099649
    Abstract: A method for identifying the source of animal waste is provided. The method includes taking DNA samples from a known group of animals, conducting DNA analysis on the DNA samples to prepare a genetic profile for each animal from the group, preparing a database of the genetic profiles, collecting a specimen of waste from an unknown source, conducting DNA analysis on the specimen, and comparing the DNA analysis from the specimen to the database to determine the source of the waste.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 9, 2015
    Applicant: BioVet Pet Labs
    Inventors: Ashley Michelle Burnett, Cheleigh Nicole Winfree, Kathryn Ellen Oliff, Dawn Irion
  • Publication number: 20150093817
    Abstract: A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stem cell, zygote, a cancer cell, a T-cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 2, 2015
    Applicant: Owl biomedical, Inc.
    Inventors: John S. Foster, Nicholas C. Martinez, Stefan Miltenyi, Kamala R. Qalandar, Kevin E. Shields, Kimberly L. Turner
  • Patent number: 8993314
    Abstract: A system for culturing photosynthesizing microorganisms includes a source of a gaseous fluid a mixer that creates micron bubbles within an aqueous medium using the gaseous fluid. The mixing chamber holds the aqueous medium including the micron bubbles before the micron bubbles and aqueous medium are mixed with a culture of photosynthesizing microorganism in a reaction chamber.
    Type: Grant
    Filed: July 28, 2007
    Date of Patent: March 31, 2015
    Assignee: Ennesys SAS
    Inventors: Nicholas Eckelberry, T. Riggs Eckelberry
  • Publication number: 20150087016
    Abstract: A method for processing a blood sample is provided that can improve the recovery rate of deformable rare cells that would easily pass through a filter and small rare cells while reducing the filtration area of the filter, and that can recover the rare cells alive.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 26, 2015
    Applicant: ARKRAY Inc.
    Inventor: Hidenori Takagi
  • Publication number: 20150087010
    Abstract: The present invention provides a filter member. The filter member comprises: a filter for discriminating cells to be analyzed in a sample from other components; a first filter holding member which comprises a first through hole and has a plate-like shape; and a second filter holding member which comprises a second through hole and is fitted into the first filter holding member. When the first and second filter holding members are integrated by fitting the second filter holding member into the first filter holding member, the filter is sandwiched between the first filter holding member and the second filter holding member, and the first through hole is opposed to the second through hole through the filter. A first elastic body is formed on a surface of the first filter holding member, the surface being in contact with the filter. A second elastic body is formed on a surface of the second filter holding member, the surface being in contact with the filter.
    Type: Application
    Filed: September 17, 2014
    Publication date: March 26, 2015
    Inventor: Ryuichiro EBI
  • Publication number: 20150079671
    Abstract: A device for removing material from a vesicular object, said device being a pipette having a sealed tip at its distal end and an aperture whereby the distal tip of the device is inserted into the target object, the aperture aligned with the material to be removed from the object, vacuum applied to the inside of the device, such vacuum drawing the material into the aperture, and the device being removed from the object in such a manner as to cut or otherwise separate the material in the pipette from the object, the material remaining in the pipette, while leaving the object undamaged.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Inventor: Paul J. Taylor
  • Publication number: 20150079582
    Abstract: A bismuth-containing concentration agent for microorganisms is provided. Additionally, articles that include the concentration agent and methods of concentrating a microorganism using the concentration agent are provided.
    Type: Application
    Filed: March 4, 2013
    Publication date: March 19, 2015
    Inventors: Manjiri T. Kshirsagar, Evan Koon Lun Yuuji Hajime, Andrew W. Rabins
  • Publication number: 20150079672
    Abstract: The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventors: Rouzbeh R. Taghizadeh, John Meade
  • Publication number: 20150072350
    Abstract: All of bio-related substances, such as cells or bacteria, are placed at single and independent positions. A flow cell according to the present invention is used for analyzing a bio-related substance and includes a flow passageway and an injection opening and a discharge opening that are connected to the flow passageway. The flow passageway is provided with trapping structural members for trapping the bio-related substance. The trapping structural members include a structure forming a dead water region in which the bio-related substance is trapped.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 12, 2015
    Inventors: Takuya Matsui, Muneo Maeshima
  • Publication number: 20150072411
    Abstract: A slide processing apparatus comprises a slide or processing station which may include a plurality of cuvettes, each cuvette configured to receive a slide. A reagent fluid supply is coupled to each cuvette to deliver and apply reagent for treatment of the slide. A slide gripper is disposed above the slide processing station and is configured to move the slide in and out of the cuvettes. A screw assembly is disposed adjacent the slide processing station, the screw assembly configured to receive a plurality of slides, wherein rotation of the screw assembly advances the plurality of slides for engagement by the slide gripper.
    Type: Application
    Filed: April 5, 2013
    Publication date: March 12, 2015
    Inventors: Jerry West, Randy Thomas, Jeff Gibbs, Lee Carter
  • Publication number: 20150064764
    Abstract: A device for transporting, trapping and escaping a single biomaterial using a magnetic structure, and a method of transporting, trapping and escaping of the single biomaterial using the same are provided, and a method is provided for controlling movement and direction of the single biomaterial including soft magnetic micro structure and magnetic structure in a linear, square storage, apartment type, radial soft magnetic micro structure. Accordingly, the device for transporting, trapping and escaping a single biomaterial and the method for transporting, trapping and escaping single biomaterial using the same can control movement on the lap-on-a-chip with increased precision and ease, by using magnetic force, and thus can be advantageously used in the field of magneto-resistive sensor, or categorization of single cells or biomolecules.
    Type: Application
    Filed: August 29, 2013
    Publication date: March 5, 2015
    Applicant: The Industry & Academic Cooperation in Chungnam National University (IAC)
    Inventors: Cheolgi Kim, Byeonghwa Lim, Reddy Venu, Hu XingHao, KunWoo Kim, Benjamin B. Yellen
  • Publication number: 20150056695
    Abstract: This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate.
    Type: Application
    Filed: August 21, 2014
    Publication date: February 26, 2015
    Applicant: RareCyte, Inc.
    Inventors: Joshua Nordberg, Daniel Campton, Steve Quarre, David Stewart
  • Publication number: 20150056637
    Abstract: A collection device for use in connection with off-device testing of collected samples. The device includes a first panel having one or more apertures for receiving samples, a second panel opposite the first panel, and a removable tab having a first portion and a second portion. The first portion is aligned with at least one of apertures on the first panel and constructed such that depositing the sample through the at least one aperture causes the sample to be directly deposited on the first portion of the tab, and the second portion includes a sample-free grasping area accessible from an exterior of the device for removing the tab. A method of obtaining a sample is also disclosed.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 26, 2015
    Applicant: Immunostics, Inc.
    Inventor: Vincent Lastella
  • Patent number: 8961896
    Abstract: A cytological cell sample collection, storage, and transport device is disclosed. The device comprises a sheath, a collection assembly, a base, and a containment vial. The collection assembly is slidably coupled to the base to expose a swab head comprising the collection assembly. The containment vial is configured to enclose the sheath and collection assembly within the internal volume defined by the containment vial and the base.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: February 24, 2015
    Assignee: In HindSight LLC
    Inventor: Kathy Mary McSherry
  • Publication number: 20150050726
    Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
    Type: Application
    Filed: October 28, 2014
    Publication date: February 19, 2015
    Inventors: Steve Jia Chang YU, Jesus CHING, Phillip You Fai LEE, David Hsiang HU