Insect Cell, Per Se Patents (Class 435/348)
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Publication number: 20130164270Abstract: The present invention relates to engineered polynucleotides and constructs comprising nucleic acid sequences encoding a specific splice-variant (sFLT1-14) of the VEGFR family Flt-1, methods for efficient propagation and expression thereof and compositions and uses thereof. More particularly, the invention relates to isolated polynucleotides comprising a nucleic acid sequence coding for sFlt1-14 or any fragment thereof comprising the serine-rich C-terminus region of said sFlt1-14, wherein at least one of the TCA serine coding codons in said serine-rich C-terminus region of sFlt1-14 as encoded by the nucleic acid sequence of SEQ ID NO. 1, is replaced by any one of TCT, TCC, TCG, AGT, AGC. The invention further provides compositions and method of treating VEGF-associated medical conditions using the polynucleotides of the invention.Type: ApplicationFiled: July 29, 2010Publication date: June 27, 2013Applicant: Yissum Research Developement Company of the Hebrew University of Jerusalem Ltd.Inventors: Eli Keshet, Shay Sela
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Publication number: 20130156778Abstract: The present invention provides a dendritic cell modulatory protein which modulates, and preferably inhibits, the differentiation and/or maturation of mammalian dendritic cells. The invention also provides proteins comprising conserved motifs found in such proteins as well as pharmaceutical compositions comprising the dendritic cell modulatory protein and homologues and active fragments thereof, antibodies thereto and methods of treatment which utilise such proteins, homologues, fragments and antibodies.Type: ApplicationFiled: March 23, 2011Publication date: June 20, 2013Applicant: NATURAL ENVIRONMENT RESEARCH COUNCILInventors: Jonathan M. Austyn, Guido Paesen, Stephen Preston, Patricia Nuttal
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Publication number: 20130157284Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.Type: ApplicationFiled: March 23, 2011Publication date: June 20, 2013Applicant: Board of Trustees of Michigan State UniversityInventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
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Publication number: 20130150263Abstract: Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating a novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes.Type: ApplicationFiled: May 27, 2011Publication date: June 13, 2013Inventor: Jon Elliot Adler
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Publication number: 20130152234Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: February 7, 2013Publication date: June 13, 2013Applicants: NOVOZYMES A/S, NOVOZYMES, INC.Inventors: Novozymes, Inc., Novozymes A/S
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Publication number: 20130149749Abstract: An engineered DNA polymerase characterised in that the polymerase exhibits an enhanced ability to process nucleic acid in the presence of environmental and biological inhibitors compared to wild type DNA polymerase.Type: ApplicationFiled: February 18, 2013Publication date: June 13, 2013Applicant: Medical Research CouncilInventor: Medical Research Council
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Publication number: 20130143949Abstract: A polypeptide comprising a G-CSF domain operably linked to a Tf domain, wherein the ability of the polypeptide to be transported into a cell expressing a TfR gene or the ability of the polypeptide to be transported across a cell expressing a TfR gene via transcytosis is higher than that of the G-CSF domain alone.Type: ApplicationFiled: May 1, 2012Publication date: June 6, 2013Applicants: NATIONAL INSTITUTE OF HEALTHInventors: Wei-Chiang SHEN, Yun BAI, David ANN, Adam WIDER
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Publication number: 20130143265Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.Type: ApplicationFiled: January 14, 2013Publication date: June 6, 2013Applicant: ZymoGenetics, Inc.Inventor: ZymoGenetics, Inc.
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Publication number: 20130137604Abstract: The invention relates to compositions for evaluating a genetic element and methods of use.Type: ApplicationFiled: November 29, 2012Publication date: May 30, 2013Applicant: Raytheon BBN Technologies Corp.Inventor: Raytheon BBN Technologies Corp.
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Publication number: 20130137152Abstract: The present invention relates to isolated polypeptides having glucoamylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains.Type: ApplicationFiled: November 28, 2012Publication date: May 30, 2013Applicants: Novozymes North America, Inc., Novozymes A/SInventors: Novozymes A/S, Novozymes North America, Inc.
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Publication number: 20130129766Abstract: Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.Type: ApplicationFiled: November 1, 2012Publication date: May 23, 2013Inventors: Shirley LONGACRE, Hannah POLSON, Ronald PERRAUT, Faridabano NATO
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Publication number: 20130129742Abstract: The present invention relates to a polypeptide, described as a lectin, its encoding nucleic acid sequence and antibodies to the polypeptide and their use in various medical applications, particularly for treating or preventing an autoimmune disorder, an inflammatory disorder or damaged skin in an animal.Type: ApplicationFiled: April 28, 2011Publication date: May 23, 2013Applicant: LEUKOLECT ASInventors: Bernt Th. Walther, Mirushe Miftari
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Publication number: 20130129737Abstract: This invention provides an isolated nucleic acid encoding a polypeptide comprising amino acid sequences of a streptococcal matrix adhesion E (EmaE) polypeptide. Antibodies to the EmaE polypeptide and immunogenic fragments thereof are also provided. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptide, antibodies thereto, and nucleic acids.Type: ApplicationFiled: February 18, 2011Publication date: May 23, 2013Applicants: University of Utah Research Foundation, St. Jude Children's Research HospitalInventors: Elisabeth Adderson, John Bohnsack
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Publication number: 20130130347Abstract: The present invention is directed to a synthetic nucleic acid scaffold comprising one or more subunits, each subunit comprising two or more different protein-binding sequences coupled together. The present invention further relates to systems and methods for assembling a synthetic biological pathway and producing a biological pathway product or a precursor product using the synthetic nucleic acid scaffold.Type: ApplicationFiled: October 9, 2012Publication date: May 23, 2013Applicant: CORNELL UNIVERSITYInventor: Cornell University
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Publication number: 20130129764Abstract: The invention relates to compositions and methods for the detection of various infectious organisms, including heartworm (Dirofilaria immitis), Ehrlichia Canis, Anaplasma phagocytophilum, and Borrelia burgdorferi. More particularly, this invention relates to antibodies that bind to a heartworm antigen, the E. Canis gp36 polypeptide, the A. phagocytophilum p44 polypeptide, the B. burgdorferi OspA, OspC, OspF, p39, p41 and VlsE polypeptides, and uses thereof.Type: ApplicationFiled: November 2, 2012Publication date: May 23, 2013Applicant: VCA Antech, Inc.Inventor: VCA Antech, Inc.
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Publication number: 20130130326Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicants: NOVOZYMES, INC., NOVOZYMES A/SInventors: Novozymes A/S, Novozymes, Inc.
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Publication number: 20130130330Abstract: A novel glycosyl hydrolase with activities of beta-xylosidase and beta-glucosidase is provided. Said glycosyl hydrolase can convert 7-xylosyltaxane compounds to 7-hydroxyltaxane compounds.Type: ApplicationFiled: April 12, 2011Publication date: May 23, 2013Applicant: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF ME SCIENCESInventors: Ping Zhu, Haili Cheng, Ruiyu Zhao, Kedi Cheng, Huixia He, Chao Meng, Huixin Zhu
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Publication number: 20130133102Abstract: A conserved region of sequence in bacterial microcompartment (BMC) enzymes and proteins was identified. Peptide sequences derived from this conserved region of native BMC proteins and enzymes appear to target the hexameric facets of BMC shell proteins. These peptides were predicted to share general properties of a predicted alpha helical conformation, flanked by poorly conserved segment(s) of primary structure); for each type of encapsulated protein, and for each functionally distinct BMC. These peptides can be used as targeting signals for integrating biomolecules and molecules into bacterial microcompartments or for attaching molecules or biomolecules to native or non-native bacterial microcompartment shell proteins.Type: ApplicationFiled: August 1, 2012Publication date: May 23, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Cheryl A. Kerfeld, James N. Kinney
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Publication number: 20130129767Abstract: The present invention relates to specific regions of the N-terminal portion of the VAR2CSA protein and to the use of such specific regions in the prevention of pregnancy-associated malaria. The invention also provides immunogenic compositions and vaccines that are useful for preventing malaria in pregnant women.Type: ApplicationFiled: July 29, 2011Publication date: May 23, 2013Applicant: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)Inventors: Nicaise Tuikue Ndam, Philippe Deloron, Sedami Ursula Alix Carine Gnidéhou, Mickaël Quiviger, Pascal Bigey, Daniel Scherman
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Publication number: 20130129761Abstract: Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.Type: ApplicationFiled: March 30, 2011Publication date: May 23, 2013Applicant: Mount Sinai School of MedicineInventors: Adolfo Garcia-Sastre, Peter Palese, John Steel, Anice C. Lowen
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Publication number: 20130130248Abstract: The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.Type: ApplicationFiled: November 7, 2012Publication date: May 23, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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Publication number: 20130130325Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicants: NOVOZYMES, INC., NOVOZYMES A/SInventors: Novozymes A/S, Novozymes, Inc.
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Patent number: 8445231Abstract: The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.Type: GrantFiled: August 26, 2011Date of Patent: May 21, 2013Assignee: University of Kentucky Research FoundationInventors: Joseph Chappell, Lyle F. Ralston
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Publication number: 20130122149Abstract: The present invention relates to isolated polypeptides having glucose dehydrogenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: January 16, 2013Publication date: May 16, 2013Applicant: NOVOZYMES A/SInventor: NOVOZYMES A/S
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Publication number: 20130122592Abstract: Provided is a method for transferring an extraneous gene by an electroporation technique, which is applicable to a wide range of animal cells and is extremely remarkably improved in viability and gene transferring rate. Also provided is a method for transferring an extraneous gene by an electroporation technique with high viability and gene transferring rate even in the case where no specialized transferring buffer is used. Also provided are: a method for transferring an extraneous gene by an electroporation technique, which is remarkably improved in viability and gene transferring rate, the method including continuously applying, to an animal cell, a first electric pulse (strong electric pulse) and a second electric pulse (weak electric pulse) under specific conditions; and a method for transferring an extraneous gene by an electroporation technique, in which a liquid medium capable of being used for culturing of the animal cell is used as a transferring buffer.Type: ApplicationFiled: January 12, 2011Publication date: May 16, 2013Applicant: NEPA GENE CO., LTD.Inventors: Yasuhiko Hayakawa, Kiyoshi Hayakawa
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Publication number: 20130122034Abstract: The novel protein SA1789 from Staphylococcus aureus is provided as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Also provided is a composition, particularly a S. aureus vaccine, comprising SA1789 protein or a fragment or derivative thereof capable of generating an immune response that leads to the killing and clearance of S. aureus.Type: ApplicationFiled: July 8, 2011Publication date: May 16, 2013Inventors: Tessie B. McNeely, Hongxia Fan, Mark Andrew Miller
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Publication number: 20130122585Abstract: The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The invention further relates to the generation of packaging cells and vaccines based on the synthetic gag and gagpol genes.Type: ApplicationFiled: September 14, 2012Publication date: May 16, 2013Applicant: GENEART AGInventors: Ralf WAGNER, Marcus Graf, Ludwig Deml, Kurt Bieler
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Publication number: 20130123163Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: January 22, 2013Publication date: May 16, 2013Applicants: NOVOZYMES A/S, NOVOZYMES, INC.Inventors: Novozymes, Inc., Novozymes A/S
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Publication number: 20130122545Abstract: The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: January 17, 2013Publication date: May 16, 2013Applicant: NOVOZYMES A/SInventor: NOVOZYMES A/S
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Publication number: 20130115663Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.Type: ApplicationFiled: October 23, 2012Publication date: May 9, 2013Applicant: CODEXIS, INC.Inventor: Codexis, Inc.
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Publication number: 20130115635Abstract: Described is an epitope tag useful in affinity-based applications. The invention further includes fusion proteins, methods for preparing fusion proteins, nucleic acid molecules encoding these fusion proteins and recombinant host cells that contain these nucleic acid molecules. The invention also relates to nanobodies and other affinity ligands specifically recognizing the epitope tag, and uses thereof in affinity-based applications.Type: ApplicationFiled: May 25, 2011Publication date: May 9, 2013Inventors: Els Pardon, Jan Steyaert, Lode Wyns
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Publication number: 20130116182Abstract: Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.Type: ApplicationFiled: November 15, 2010Publication date: May 9, 2013Inventors: Kathleen Pratt, Ruth Ettinger, Eddie Arthur James
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Publication number: 20130117872Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.Type: ApplicationFiled: September 14, 2012Publication date: May 9, 2013Inventors: Subba Reddy PALLI, Mohan Basavaraju Kumar, Dean Ervin Cress, Ted Tsutomu Fujimoto
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Publication number: 20130117881Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.Type: ApplicationFiled: October 30, 2012Publication date: May 9, 2013Applicant: CERES, INC.Inventor: Ceres, Inc.
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Publication number: 20130108654Abstract: The present invention provides a telomerase activity inhibiting polypeptide. The expression of the polypeptide in tumor cells can inhibit significantly tumor cell telomerase activity, tumor cell growth, and lead to the death of such cells. The present invention further provides a preparation method for the polypeptide and an application thereof in targeted treatments of tumors.Type: ApplicationFiled: July 4, 2011Publication date: May 2, 2013Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CASInventors: Mujun Zhao, Jian Feng, Guoyuan Chen, Jing Zhao, Guangming Chen, Liang Da, Zaiping Li
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Publication number: 20130108642Abstract: The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.Type: ApplicationFiled: September 14, 2012Publication date: May 2, 2013Inventors: Ashraf S. Ibrahim, Mingfu Liu, Teklegiorgis Ghebremariam, Yue Fu, John E. Edwards, Scott Filler
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Publication number: 20130108660Abstract: The present invention relates to the identification of nucleotide and peptide sequences of a novel HDL transporter located in the flagellar pocket of African trypanosome parasites, and to the use thereof for anti-trypanosomosis diagnostic, therapeutic and vaccine applications in man and in animals.Type: ApplicationFiled: November 10, 2010Publication date: May 2, 2013Inventors: Virginie Coustou Linares, Theo Baltz, Magali Thonnus
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Publication number: 20130109075Abstract: The subject invention provides novel polynucleotides and polypeptides encoding a methyltransferase. The subject invention provides novel plants that express the methyltransferase disclosed herein and are resistant to auxin-based herbicides. The subject invention also provides transgenic plants have been transformed with one or more other herbicide resistance genes such that the plants are resistant to the application of auxin-based herbicides and one or more other herbicides.Type: ApplicationFiled: December 19, 2012Publication date: May 2, 2013Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventor: University of Tennessee Research Foundation
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Patent number: 8431769Abstract: Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the non-aggregating feature arises from the modulation of residues in the N-terminus of the protein and the chromo and/or fluorescent feature arises from the interaction of two or more residues of the protein. Also provided are fragments of the subject nucleic acids and the peptides encoded thereby, as well as antibodies to the subject proteins and transgenic cells and organisms. The subject protein and nucleic acid compositions find use in a variety of different applications. Finally, kits for use in such applications, e.g., that include the subject nucleic acid compositions, are provided.Type: GrantFiled: December 5, 2011Date of Patent: April 30, 2013Assignee: Clontech Laboratories, Inc.Inventors: Sergey Lukyanov, Konstantin Lukyanov, Yuriy Yanushevich, Alexandr Savitsky, Arcady Fradkov
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Publication number: 20130101577Abstract: Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.Type: ApplicationFiled: February 21, 2012Publication date: April 25, 2013Inventors: Ge Wei, Krishnasamy Panneer Selvam, Louis Bookbinder, Gregory I. Frost
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Publication number: 20130102482Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided.Type: ApplicationFiled: September 28, 2012Publication date: April 25, 2013Applicants: Board of Regents, The University of Texas System, Millennium Pharmaceuticals, Inc.Inventors: Millennium Pharmaceuticals, Inc., Board of Regents, The University of Texas System
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Publication number: 20130101590Abstract: The invention provides novel BTNL9 proteins, including multimers, fragments, and variants of a human BTNL9 protein. In addition, antibodies that can bind to BTNL9 proteins and nucleic acids encoding BTNL9 proteins are provided. Uses for BTNL9 proteins, and agonists or antagonists thereof, are described.Type: ApplicationFiled: April 8, 2011Publication date: April 25, 2013Inventors: Heather A. Arnett, Sabine S. Escobar, Ryan M. Swanson, Joanne L. Viney
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Publication number: 20130095533Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.Type: ApplicationFiled: April 15, 2011Publication date: April 18, 2013Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CLORADO STATE UNIVERSITY RESEARCH FOUNDATION, ALLEGHENY-SINGER RESEARCH INSTITUTEInventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
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Publication number: 20130095569Abstract: The present invention provides pregnancy associated plasma protein A2 (PAPP-A2), its nucleotide and amino acid sequences antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide sequences, genetically engineered host cells for the expression of PAPP-A2, and methods for screening for pathologies in pregnant and non-pregnant patients. Methods for screening for altered focal proliferation states in pregnant and/or non-pregnant patients, which include detecting levels of PAPP-A2, are also described.Type: ApplicationFiled: September 24, 2012Publication date: April 18, 2013Inventors: Claus Oxvig, Michael Toft Overgaard
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Patent number: 8420350Abstract: The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.Type: GrantFiled: March 12, 2010Date of Patent: April 16, 2013Inventors: Toshikazu Nakamura, Kunio Matsumoto, Kazuhiro Fukuta
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Publication number: 20130089893Abstract: A soluble multimeric protein or polypeptide is disclosed that is able to inhibit interaction of leukocyte Fc? receptors (Fc?R) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more linked Fc binding regions, at least one of which is derived from an Fc?R type receptor and, particularly, Fc?RIIa. Also described are polynucleotide molecules encoding the protein or polypeptide and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease.Type: ApplicationFiled: December 6, 2012Publication date: April 11, 2013Applicant: SUPPREMOL GMBHInventor: Suppremol GMBH
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Publication number: 20130089558Abstract: The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre-m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.Type: ApplicationFiled: June 2, 2009Publication date: April 11, 2013Inventors: Frédéric Tangy, PHILIPPE DESPRES, CHANTAL COMBREDET, MARIE PASCALE FRENKIEL
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Publication number: 20130089898Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.Type: ApplicationFiled: June 16, 2011Publication date: April 11, 2013Applicant: CODEXIS, INC.Inventors: Fabien Cabirol, Anupam Gohel, Seong Ho Oh, Derek Smith, Brian Wong, James Lalonde
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Publication number: 20130090263Abstract: The invention is directed to polypeptides having a fluorescent activity, e.g., an auto-fluorescent activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as noninvasive fluorescent markers in living cells and intact organs and animals. The polypeptides of the invention can be used as, e.g., in vivo markers/tracers of gene expression and protein localization, activity indicators, fluorescent resonance energy transfer (FRET) markers, cell lineage markers/tracers, reporters of gene expression and as markers/tracers in protein-protein interactions.Type: ApplicationFiled: November 30, 2012Publication date: April 11, 2013Applicant: BP CORPORATION NORTH AMERICA INC.Inventor: BP CORPORATION NORTH AMERICA INC.
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Patent number: 8415525Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.Type: GrantFiled: September 6, 2011Date of Patent: April 9, 2013Assignee: Zoetis W LLCInventors: André Jestin, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec