Brevibacterium Patents (Class 435/840)
  • Patent number: 10011602
    Abstract: The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: July 3, 2018
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventors: Lars Kjer-Nielsen, James McCluskey, Alexandra Corbett, Jamie Rossjohn, Patel Onisha, David Paul Fairlie, Ligong Liu
  • Patent number: 7192760
    Abstract: The present invention provides novel microorganisms, Brevibacterium lactofermentum CJJA21 (Accession No. KCCM-10222), which is resistant to sodium azide, and Brevibacterium lactofermentum CJJA22 (Accession No. KCCM-10223), which is resistant to ?-aminobutyric acid. These microorganisms are capable of producing L-glutamine in a higher yield than the known strains. The present invention further provides processes for producing L-glutamine using the microorganisms of the invention.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: March 20, 2007
    Assignee: Cheil Jedang Corporation
    Inventors: Sung-Sik Park, Seung-Hyun Suh, Keun-Chul Lee, Dong-Woo Lee, Cheon-Ju Kim, Sang-Cheol Jeong
  • Patent number: 6984506
    Abstract: The present invention provides novel microorganisms, Brevibacterium lactofermentum CJJA21 (Accession No. KCCM-10222), which is resistant to sodium azide, and Brevibacterium lactofermentum CJJA22 (Accession No. KCCM-10223), which is resistant to ?-aminobutyric acid. These microorganisms are capable of producing L-glutamine in a higher yield than the known strains. The present invention further provides processes for producing L-glutamine using the microorganisms of the invention.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: January 10, 2006
    Assignee: Cheil Jedang Corporation
    Inventors: Sung-Sik Park, Seung-Hyun Suh, Keun-Chul Lee, Dong-Woo Lee, Cheon-Ju Kim, Sang-Cheol Jeong
  • Patent number: 6777224
    Abstract: The present invention provides a method for enzymatically producing optically active mandelic acid derivatives. An optically active mandelic acid derivative (shown as Formula II) is produced by reacting a culture or cell body of a microorganism, or processed products thereof, with a phenylglyoxylic acid derivative, and then recovering the obtained optically active mandelic acid derivative, wherein the microorganism has the ability to stereo-selectively reduce the phenylglyoxylic acid derivative. An optically active mandelic acid obtained according to the present invention is useful as an intermediate for the synthesis of pharmaceuticals and agricultural chemicals.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: August 17, 2004
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Kazuya Mitsuhashi, Hiroaki Yamamoto
  • Patent number: 6258554
    Abstract: An industrially more advantageous method for the production of metabolites biologically synthesized via phosphoribosyl pyrophosphate (PRPP) is provided, making use of metabolically modified strains in which transketolase activity is deficient or reduced in comparison with the parent strain.
    Type: Grant
    Filed: July 22, 1999
    Date of Patent: July 10, 2001
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masato Ikeda, Kazuyuki Okamoto, Tetsuo Nakano, Nozomu Kamada
  • Patent number: 5968788
    Abstract: Disclosed is a method for producing folic acid, comprising incubating yeast having the ability to produce folic acid of 0.3 mg or more or incubating bacteria having the ability to produce folic acid of 1 mg or more per liter of the culture, thereby accumulating folic acid in the culture.
    Type: Grant
    Filed: August 26, 1996
    Date of Patent: October 19, 1999
    Assignee: Toray Industries, Inc.
    Inventors: Reiko Miyata, Tetsu Yonehara
  • Patent number: 5869300
    Abstract: A method for producing L-glutamic acid, comprising inoculating a microorganism having an ability to produce L-glutamic acid, in a liquid medium containing a carbon source and a nitrogen source, conducting continuous L-glutamic acid fermentation in which both a carbon source and a nutrient having an effect of promoting bacterial growth are fed so as to make the microorganism grow, and then collecting L-glutamic acid produced and accumulated in a culture broth.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: February 9, 1999
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tatsuya Yoshioka, Toshimasa Ishii, Yoshio Kawahara, Yosuke Koyama, Eiko Shimizu
  • Patent number: 5846790
    Abstract: A mutant strain having an ability to produce L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity with respect to a biotin action-suppressing agent to a coryneform L-glutamic acid-producing bacterium. This strain is cultivated in a liquid medium to produce and accumulate L-glutamic acid in the medium. A mutant strain having an ability to produce L-lysine and L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity with respect to a biotin action-suppressing agent and giving L-lysine productivity to a coryneform L-glutamic acid-producing bacterium. This strain is cultivated in a liquid medium to simultaneously produce and accumulate L-lysine and L-glutamic acid in the medium.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: December 8, 1998
    Assignee: Ajinomoto Co., Inc.
    Inventors: Eiichiro Kimura, Yoko Asakura, Akinori Uehara, Sumio Inoue, Yoshio Kawahara, Yasuhiko Yoshihara, Tsuyoshi Nakamatsu
  • Patent number: 5840551
    Abstract: A method of producing L-amino acids by fermentation. Microorganisms of the genus Corynebacterium which exhibit an auxotrophy relative to an amino acid are used as biocatalysts. The method is characterized in that the carbon source on the one hand and the limiting amino acid on the other hand are fed in two or more different infeed currents to the process. The infeed profiles have, for example, a concave (saccharose) and an exponential (amino acid) form or a convex (saccharose) and likewise a convex (amino acid) form, with specific differing degrees of increase of the currents relative to each other over time.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: November 24, 1998
    Assignee: Degussa Aktiengesellschaft
    Inventors: Holger Werning, Harald Voss, Walter Pfefferle, Wolfgang Leuchtenberger
  • Patent number: 5707833
    Abstract: This invention relates to a .gamma.-cyclodextrin glucanotransferase having novel properties, to a process for the production of the .gamma.-cyclodextrin glucanotransferase which comprises culturing a strain belonging to the genus Brevibacterium capable of producing cyclodextrin glucanotransferase, thereby allowing the strain to produce the .gamma.-cyclodextrin glucanotransferase in a culture medium, and subsequently collecting the enzyme, to a process for the production of cyclodextrin which comprises allowing the cyclodextrin glucanotransferase to react with substrate dissolved in a solution, thereby effecting formation of .gamma.-cyclodextrin as a main product, and to a method for increasing .gamma.-cyclodextrin yield without accompanying yield increase of total cyclodextrin, which comprises adding ethyl alcohol to a reaction solution in which .gamma.-cyclodextrin and .beta.-cyclodextrin are formed from starch by the action of .gamma.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 13, 1998
    Assignee: Amano Pharmaceutical Co., Ltd.
    Inventors: Shigeharu Mori, Tamio Mase, Takaichi Ohya
  • Patent number: 5705370
    Abstract: Culturing an L-amino acid producing microorganism belonging to the genus Brevibacterium or Corynebacterium and having a resistance to a peptide containing glutamic acid or aspartic acid gives L-amino acids in high yield.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: January 6, 1998
    Assignee: Ajinomoto Company, Inc.
    Inventors: Takayasu Tsuchida, Haruo Uchibori, Hiroshi Takeuchi, Mitsuyoshi Seki
  • Patent number: 5677156
    Abstract: Fumaric acid is produced by reacting maleic acid in an aqueous solution with a microorganism which has maleate isomerase activity or with a preparation from the microorganism having the maleate isomerase activity, and producing fumaric acid in a reaction solution by enzymatic isomerization of maleic acid carried out under the condition that the dissolved oxygen concentration in the reaction solution is substantially maintained at 4 ppm or less, for example, by sealing the reaction solution with one or more gases selected from N.sub.2, Ar, and He.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: October 14, 1997
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Makoto Goto, Izuru Tokumaru, Masato Terasawa, Hideaki Yukawa
  • Patent number: 5665560
    Abstract: A process for producing cholesterol oxidase from a recombinant microorganism, the microorganism itself and its recombinant plasmid are disclosed. The cholesterol oxidase has a particular amino acid sequence, a high substrate affinity and a working pH in the acidic range. The gene for this cholesterol oxidase was derived from Brevibacterium sterolicum. The cholesterol oxidase is used for the quantitative determination of cholesterol.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 9, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kinya Fujishiro, Takayuki Uwajima
  • Patent number: 5650304
    Abstract: The present invention relates to (a) process for producing L-lysine by fermentation which comprises culturing a microorganism having resistance to 4-N-(D-alanyl)-2,4-diamino-2,4-dideoxy-L-arabinose 2,4-dideoxy-L-arabinose or a derivative thereof and belonging to the genus Brevibacterium or the genus Corynebacterium, (b) said bacterium therefore and (c) a method of producing said bacterium.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: July 22, 1997
    Assignee: Ajinomoto Co., Inc.
    Inventors: Toshimasa Ishii, Manabu Yokomori, Harufumi Miwa
  • Patent number: 5624828
    Abstract: The present invention provides a process for producing substances such as L-tryptophan and L-threonine, which comprises transforming a serine-requiring microorganism belonging to the genus Corynebacterium or Brevibacterium by incorporation of a recombinant plasmid containing a gene which complements the serine-requirement of the host and a gene which relates to the biosynthesis of a desired substance; culturing the obtained transformant in a culture medium; allowing the substance produced by the transformant to accumulate in the culture; and recovering the substance from the culture.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: April 29, 1997
    Assignee: Kyowa Hakko Kogyo Co. Ltd.
    Inventors: Ryoichi Katsumata, Masato Ikeda, Keiko Nakanishi, Yuko Sasao
  • Patent number: 5602017
    Abstract: A process for producing cholesterol oxidase from a recombinant microorganism, the microorganism itself and its recombinant plasmid are disclosed. The cholesterol oxidase has a particular amino acid sequence, a high substrate affinity and a working pH in the acidic range. The gene for this cholesterol oxidase was derived from Brevibacterium sterolicum.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: February 11, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kinya Fujishiro, Takayuki Uwajima
  • Patent number: 5599698
    Abstract: The invention relates to modified materials based on polyacrylonitrile having amidic groups on their surface. The modification gives the material greater hydrophilic characteristics improving its comfort properties. In addition, it permits the polyacrylonitrile to be dyed also with acidic dyes thus making it possible for it to be used for the preparation of yarns mixed with natural fibres, such as wool for example. The process for their production involves treatment of the material with enzymes of the nitrile hydratasis class obtained from Brevibacterium imperiale.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 4, 1997
    Assignee: Montefibre S.p.A.
    Inventors: Ezio Battistel, Franco Francalanci, Massimo Marinetti, Marco Morra
  • Patent number: 5597716
    Abstract: The present invention relates to a process for producing D-lactic acid and L-lactamide, comprising allowing a culture broth of a microorganism capable of asymmetric hydrolysis of DL-lactamide belonging to the genus Alcaligenes, Pseudomonas, Agrobacterium, Brevibacterium, Acinetobacter, Corynebacterium, Enterobacter, Micrococcus or Rhodococcus, the microorganism itself, a material obtained therefrom or an immobilized material thereof to act on DL-lactamide, and recovering the resulting D-lactic acid and the remaining L-lactamide. The present invention enables sufficient production of D-lactic acid and L-lactamide by the present microorganism.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: January 28, 1997
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Eiji Sato, Eiji Ozaki, Chinami Iida, Yoshimasa Kobayashi, Akihiro Sakimae
  • Patent number: 5597727
    Abstract: The present invention relates to a DNA fragment which contains a gene responsible for the function of autonomous replication of plasmid in a Coryneform bacterium, said gene being obtained from plasmid pBY503 held in Brevibacterium stationis, and in which at least one point mutation capable of increasing the copy number of plasmid exists on said gene region. By using a Coryneform transformed with the vector constructed using said DNA fragment and an industrially useful gene such as aspartase gene or tryptophan synthase gene, production of the useful product occurs with higher efficiency than conventional methods.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: January 28, 1997
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Keiko Kohama, Kazuhisa Hatakeyama, Yasurou Kurusu, Hideaki Yukawa
  • Patent number: 5595894
    Abstract: The present invention provides a process for producing substances such as L-tryptophan and L-threonine, which comprises transforming a serine-requiring microorganism belonging to the genus Corynebacterium or Brevibacterium by incorporation of a recombinant plasmid containing a gene which complements the serine-requirement of the host and a gene which relates to the biosynthesis of a desired substance; culturing the obtained transformant in a culture medium; allowing the substance produced by the transformant to accumulate in the culture; and recovering the substance from the culture.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: January 21, 1997
    Assignee: Kyowa Hakko Kogyo Co. Ltd.
    Inventors: Ryoichi Katsumata, Masato Ikeda, Keiko Nakanishi, Yuko Sasao
  • Patent number: 5595906
    Abstract: The invention relates to a bacterial process for producing L-tryptophan, L-tyrosine or L-phenylalanine. The process utilizes a coryneform glutamic acid-producing bacterium being capable of producing L-tryptophan, L-tyrosine or L-phenylalanine and also decreased or lacked in phosphoenolpyruvate carboxylase activity. The mutant strain is then cultured in order to accumulate the amino acid in a medium and the amino acid is recovered therefrom.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: January 21, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Ryoichi Katsumata, Kuniki Kino
  • Patent number: 5521074
    Abstract: There is provided a process for producing L-valine which comprises cultivating, in a medium, a microorganism which belongs to the genus Corynebacterium or Brevibacterium, which exhibits a) an ability to produce L-valine, b) resistance to L-valine in a medium containing acetic acid as a sole carbon source, and c) sensitivity to a pyruvic acid analog in a medium containing glucose as a sole carbon source, until L-valine is accumulated in the culture broth, and recovering L-valine therefrom.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 28, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Ryoichi Katsumata, Shinichi Hashimoto
  • Patent number: 5508181
    Abstract: A process for the production of .alpha.-hydroxy acids or .alpha.-hydroxyamides in which an .alpha.-hydroxynitrile compound or a mixture consisting of an aldehyde and prussic acid, which corresponds to the nitrile compound, is allowed to undergo a microbial reaction to produce the corresponding .alpha.-hydroxy acid or .alpha.-hydroxyamide, wherein the improvement resides in that phosphite ions or hypophosphite ions are allowed to be present in the reaction system. According to the present invention, since hydrolysis or hydration of nitrile compounds can be carried out by constantly keeping a low concentration level of aldehydes which are considered to be a cause of the enzyme inhibition in the reaction system, the enzyme activity can be maintained stably for a prolonged period of time and the formed acids or amides can therefore be accumulated in a high concentration.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: April 16, 1996
    Assignee: Nitto Chemical Industry Co., Ltd.
    Inventor: Yoshihiro Hashimoto
  • Patent number: 5484714
    Abstract: A method of producing trehalose, in which a microorganism belonging to the genus Brevibacterium, Corynebacterium, Microbacterium or Arthrobacter and having the ability to produce trehalose is incubated in a liquid medium containing sucrose or maltose as an essential carbon source and the trehalose produced and accumulated in the culture is collected therefrom. Trehalose is produced inexpensively and efficiently by industrial mass-production.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: January 16, 1996
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takayasu Tsuchida, Yutaka Murakami, Yoshitaka Nishimoto, Takuya Kotani
  • Patent number: 5470732
    Abstract: A restriction enzyme is obtained by cultivating a strain of Brevibacterium linens and recovering the restriction enzyme.
    Type: Grant
    Filed: April 22, 1991
    Date of Patent: November 28, 1995
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Katsuhiko Yamamoto, Hiroaki Sagawa, Hirokazu Kotani, Nobutsugu Hiraoka, Teruya Nakamura
  • Patent number: 5436145
    Abstract: 6-Hydroxy nitrogen-containing 6-membered ring compounds of the following general formula (II): ##STR1## wherein R.sup.1 represents carboxy group, carbamoyl group, cyano group, formyl group, C.sub.1 -C.sub.5 hydroxyalkyl group, C.sub.2 -C.sub.6 alkoxycarbonyl group, carboxyvinyl group, carboxymethyl group or oxime group, R.sup.2 represents hydrogen atom or carboxy group, and A represents carbon atom or nitrogen atom, can be prepared by reacting a nitrogen-containing 6-membered ring compounds of the following general formula (I): ##STR2## wherein R.sup.1, R.sup.2 and A are as defined in the general formula (II) above, with a microorganism or physico-chemically treated microorganism in an aqueous medium. Efficiency of the above reaction can be raised by conducting the reaction in the presence of phenazine methosulfate.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: July 25, 1995
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Mari Yasuda, Haruyuki Ohkishi, Katsutoshi Sato, Yuuki Morimoto, Toru Nagasawa
  • Patent number: 5429935
    Abstract: Optically active 2-hydroxy-4-phenyl-3-butenoic acid can be obtained by treating 2-oxo-4-phenyl-3-butenoic acid with an optionally treated microorganism capable of asymmetrically reducing the 2-oxo-4-phenyl-3-butenoic acid into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid to thereby asymmetrically reduce the same into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (s) -2-hydroxy-4-phenyl-3-butenoic acid.
    Type: Grant
    Filed: August 5, 1993
    Date of Patent: July 4, 1995
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Akinobu Matsuyama, Ichiro Takase, Yoichiro Ueda, Yoshinori Kobayashi
  • Patent number: 5420023
    Abstract: A process for producing L-phenylalanine at high rates of formation and in good yields is provided which comprises allowing a microorganism which belongs to the genus Nocardia and is capable of producing L-phenyl-alanine from phenylpyruvic acid or a salt thereof and an amino group donor to act upon an aqueous solution containing phenylpyruvic acid or a salt thereof and an amino group donor selected from the group consisting of ammonium salts and ammonia in a hydrogen gas atmosphere.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: May 30, 1995
    Assignee: Kuraray Co., Ltd.
    Inventors: Tadashi Matsunaga, Takanori Kitamura
  • Patent number: 5372810
    Abstract: A composition and method for the prevention and treatment of diarrhea in domesticated animals, comprising sterilized cells of aerobic bacteria belonging to the genus Bacillus, Brevibacterium, Corynebacterium, Escherichia, Lactobacillus, Streptococcus, or Streptomyces, a cell homogenate of said sterilized cells, a cell wall component-containing fraction of said homogenate or mixtures thereof. In particular species of Corynebacterium glutamicum and Brevibacterium lactofermentum as well as strains thereof, such as A.T.C.C. 13060 and A.T.C.C. 13869, respectively, are useful in the treatment of diarrhea in domesticated animals.
    Type: Grant
    Filed: November 9, 1992
    Date of Patent: December 13, 1994
    Assignee: Ajinomoto Company, Inc.
    Inventors: Norimasa Onishi, Akihiro Yamashiro
  • Patent number: 5371005
    Abstract: A cholesterol oxidase having a particular amino acid sequence and having a high substrate affinity and a working pH in an acidic range is produced by Brevibacterium sterolicum.
    Type: Grant
    Filed: February 8, 1993
    Date of Patent: December 6, 1994
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kinya Fujishiro, Takayuki Uwajima
  • Patent number: 5362636
    Abstract: A process for producing L-lysine, which comprises culturing a mutant L-lysine-producing strain belonging to the genus Brevibacterium or the genus Corynebacterium and having selenalysine resistance in a nutrient medium, producing and accumulating L-lysine in the culture broth and collecting L-lysine from the culture broth.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: November 8, 1994
    Assignee: Ajinomoto Co., Inc.
    Inventors: Manabu Yokomori, Takeshi Niwa, Kazuhiko Totsuka, Yoshio Kawahara, Shigeru Nakamori, Nobuyoshi Esaki, Kenji Soda
  • Patent number: 5326693
    Abstract: A basic L-amino acid and an acidic L-amino acid may be concurrently produced by either culturing a basic L-amino acid-producing bacteria under conditions for producing an acidic L-amino acid or mix-culturing a basic L-amino acid-producing bacteria and an acidic L-amino acid-producing bacteria.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: July 5, 1994
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hideo Kuronuma, Harufumi Miwa, Shigeru Nakamori, Toshimasa Ishii, Yasuhiko Yoshihara
  • Patent number: 5304476
    Abstract: The present invention relates to a fermentation process using a L-lysine-producing microorganism having a resistance to an acyl-lysine, a methylated acyl-lysine or both an acyl-lysine and a methylated acyl-lysine. By the process of the present invention, L-lysine may be produced in high yields providing an improved process that reduces the cost of industrially produced L-lysine.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: April 19, 1994
    Assignee: Ajinomoto Co., Inc.
    Inventors: Manabu Yokomori, Kazuhiko Totsuka, Yoshio Kawahara, Harufumi Miwa, Tsuyoshi Osumi
  • Patent number: 5302528
    Abstract: A process is described for the separation of the optical isomers of alphayl- or alpha-aryloxy- carboxylic acids by means of the stereoselective hydrolysis of racemic alkyl esters of the above acids in the presence of bacteria or their enzymes, selected from the species Brevibacterium, Bacteridium, Micrococcus, and Bacillus.
    Type: Grant
    Filed: April 22, 1992
    Date of Patent: April 12, 1994
    Assignee: Ministero Dell `Universita` e Della Ricerca Scientifica e Technologica
    Inventors: Ezio Battistel, Daniele Bianchi, Pietro Cesti, Giuliana Franzosi, Roberto Tassinari, Sandro Spezia
  • Patent number: 5294547
    Abstract: Culturing an L-amino acid producing microorganism belonging to the genus Brevibacterium or corynebacterium and having a resistance to a dipeptide containing glutamic acid or aspartic acid gives L-amino acids in high yield.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: March 15, 1994
    Assignee: Ajinomoto Company, Inc.
    Inventors: Takayasu Tsuchida, Haruo Uchibori, Hiroshi Takeuchi, Mitsuyoshi Seki
  • Patent number: 5288620
    Abstract: Optically active 2-hydroxy-4-phenyl-3-butenoic acid can be obtained by treating 2-oxo-4-phenyl-3-butenoic acid with an optionally treated microorganism capable of asymmetrically reducing the 2-oxo-4-phenyl-3-butenoic acid into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid to thereby asymmetrically reduce the same into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: February 22, 1994
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Akinobu Matsuyama, Ichiro Takase, Yoichiro Ueda, Yoshinori Kobayashi
  • Patent number: 5284757
    Abstract: L-arginine is produced in high yields by culturing a microorganism of the genus Brevibacterium or the genus Cornyebacterium, which is resistant to a compound of the formula X-guanidine, wherein X is an aliphatic group or derivative thereof. The preferred microorganisms are Brevibacterium flavum FERM BP-2227 and Corynebacterium glutamicum FERM BP-2228.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: February 8, 1994
    Assignee: Ajinomoto Company, Inc.
    Inventors: Takayasu Tsuchida, Noboro Ohtsuka, Hiroshi Takeuchi, Haruo Uchibori
  • Patent number: 5272067
    Abstract: A process for the production of L-glutamic acid comprising growing microorganisms belonging to the genera Brevibacterium and Corynebacterium that are resisted to prumycin.
    Type: Grant
    Filed: February 4, 1992
    Date of Patent: December 21, 1993
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takayasu Tsuchida, Mitsuyoshi Seki, Haruo Uchibori, Hiroki Kawashima, Hitoshi Enei
  • Patent number: 5254464
    Abstract: It is possible to produce and accumulate D-alanine selectively and to improve the amount of production and accumulation of D-alanine by cultivating a microorganism having both an ability to produce D-alanine and a resistance to D-cycloserine and belonging to the genus Brevibacterium.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: October 19, 1993
    Assignee: Toray Industries, Inc.
    Inventors: Masae Takeuchi, Tetsu Yonehara
  • Patent number: 5244803
    Abstract: There is disclosed a process for preparing optically active 3-phenylglycidic acid ester compound, which comprises permitting a culture broth, cells or treated cells of a microorganism having an ability of stereoselectively hydrolyzing a (2R, 3S)-3-phenylglycidic acid ester compound to act on a racemic 3-phenylglycidic acid ester compound which may also have a substituent on the phenyl group, thereby hydrolyzing the (2R, 3S) optically active isomer and separating and collecting the (2S, 3R) antipode from the reaction mixture.
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: September 14, 1993
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Takao Mori, Toshiyuki Furutani, Akio Nakao, Atsuhiko Tsujimura, Takeji Shibatani
  • Patent number: 5223416
    Abstract: A process for the predominantly producing R(-)-mandelic acid or a derivative thereof which comprises subjecting (i) R,S-mandelonitrile or a derivative thereof, or (ii) a mixture of prussic acid and benzaldehyde or a derivative of benzaldehyde to the action of a microorganism selected from the group consisting of the genus Aureobacterium, Pseudomonas, Caseobacter, Alcaligenes, Acinetobacter, Brevibacterium, Nocardia, and Bacillus or treated cells thereof, which the microorganism is capable of stereospecifically hydrolyzing a nitrile group of the R,S-mandelonitrile or a derivative thereof, in a neutral or basic aqueous reaction system to produce the R(-)-mandelic acid.
    Type: Grant
    Filed: March 29, 1991
    Date of Patent: June 29, 1993
    Assignee: Nitto Chemical Industry Co., Ltd.
    Inventors: Takakazu Endo, Koji Tamura
  • Patent number: 5212077
    Abstract: The invention relates to a method for producing an organic compound from manure, including the steps of:i) concentrating the manure to form a vapor;ii) condensing said vapor to form a condensate;iii) adding to said condensate micro-organisms which are capable of producing the organic compound; andiv) separating from the condensate the organic compound produced by the micro-organisms.These micro-organisms comprise species of the genera Arthrobacter, Brevibacterium, Corynebacterium, Bacillus, Escherichia, Microbacterium, Micrococcus and Pseudomonas.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: May 18, 1993
    Assignee: MeMon B.V.
    Inventor: Erik D. J. Bleeker
  • Patent number: 5200326
    Abstract: The invention is directed to a method of producing L-amino acids from .alpha.-ketocarboxylic acids by means of continuous fermentation with the aid of glutamate producing bacteria with biomass retention in which the cells are separated by microfiltration and/or centrifugal separators.
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: April 6, 1993
    Assignee: Degussa AG
    Inventors: Christian Wandrey, Rolf Wichmann, Ulrich Groeger, Manfred Kircher, Wolfgang Leuchtenberger, Eberhard Breuker
  • Patent number: 5196326
    Abstract: A basic L-amino acid and an acidic L-amino acid may be concurrently produced by either culturing a basic L-amino acid-producing bacteria under conditions for producing an acidic L-amino acid or mix-culturing a basic L-amino acid-producing bacteria and an acidic L-amino acid-producing bacteria.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: March 23, 1993
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hideo Kuronuma, Harufumi Miwa, Shigeru Nakamori, Toshimasa Ishii, Yasuhiko Yoshihara
  • Patent number: 5194380
    Abstract: Optically active 2-hydroxy-4-phenyl-3-butenoic acid can be obtained by treating 2-oxo-4-phenyl-3-butenoic acid with an optionally treated microorganism capable of asymmetrically reducing the 2-oxo-4-phenyl-3-butenoic acid into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid to thereby asymmetrically reduce the same into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: March 16, 1993
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Akinobu Matsuyama, Ichiro Takase, Yoichiro Ueda, Yoshinori Kobayashi
  • Patent number: 5188949
    Abstract: A method for producing L-threonine by fermentation which comprises culturing in a culture medium a microorganism of the genus Brevibacterium or Corynebacterium which is resistant to mycophenolic acid and is capable of producing L-threonine, accumulating L-threonine in the medium, and then recovering the L-threonine accumulated therein.
    Type: Grant
    Filed: August 22, 1990
    Date of Patent: February 23, 1993
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takayasu Tsuchida, Naoki Katsurada, Noboru Ohtsuka, Haruo Uchibori, Takeshi Suzuki
  • Patent number: 5188948
    Abstract: A process for producing L-valine by fermentation which comprises culturing in a liquid culture medium an L-valine producing microorganism which belongs to the genus Brevibacterium or Corynebacterium and which is resistant to a polyketide, and then recovering L-valine accumulated in said culture medium.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: February 23, 1993
    Assignee: Ajinomoto Co., Inc.
    Inventors: Naoki Katsurada, Haruo Uchibori, Takayasu Tsuchida
  • Patent number: 5188947
    Abstract: A process for producing L-ornithine by fermentation which comprises culturing a L-ornithine-producing microorganism is disclosed. The microorganism used belongs to the genus Brevibacterium, Corynebacterium, or Arthrobacter, has auxotrophy for arginine and/or citrulline, and has resistance to microphenolic acid and/or ornithinol.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: February 23, 1993
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takayasu Tsuchida, Haruo Uchibori, Yoshitaka Nishimoto
  • Patent number: 5182198
    Abstract: A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I): ##STR1## wherein R.sub.1 denotes straight or branched C.sub.1 -C.sub.10 hydrocarbon, and (-)-homopilopic acid ester of the general formula (II): ##STR2## wherein R.sub.2 denotes straight or branched C.sub.1 -C.sub.10 hydrocarbon, in the presence of a microorganism belonging to the genus Arthrobacter, Aspergillus, Escherichia, Cunninghamella, Xanthomonas, Candida, Pseudomonas, Serratia, Cellulomonas, Nocardia, Bacillus, Brevibacterium, Flavobacterium, Mycobacterium, Rhizomucor, Rhodotorula or Rhodococcus, or a treated matter thereof.
    Type: Grant
    Filed: November 16, 1990
    Date of Patent: January 26, 1993
    Assignee: Mitsui Petrochemical Industries, Ltd.
    Inventors: Shoichi Kise, Mikio Hayashida, Aiichiro Ori, Junzou Hiratsuka, Hideaki Yamada
  • Patent number: 5179010
    Abstract: A fermentative process for producing L-lysine is disclosed. The process is based on growing in a culture medium a mutant strain of the genus Brevibacterium or Corynebacterium (1) capable of producing L-lysine, and (2) having an intensified superoxide dismutase activity.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: January 12, 1993
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yasuhiko Yoshihara, Yoshio Kawahara, Shigeho Ikeda