Streptomyces Chartreusis Patents (Class 435/893)
  • Biocatalysts with amine acylase activity
    Patent number: 6235516
    Abstract: The invention belongs to the field of biotechnology. It concerns a biocatalyst, i.e. a dead or living microorganism or a polypeptide, preferably in isolated form, which exhibits acylase enzymatic activity without lipase- or esterase-activity. The biocatalyst is capable of stereoselectively hydrolysing a racemic acylamide which has an aliphatic acyl residue and which is not a derivative of a natural amino acid.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: May 22, 2001
    Assignee: Novartis AG
    Inventors: Oreste Ghisalba, Matthias Kittelmann, Kurt Laumen, Paula Walser-Volken
  • Method of producing carnitine
    Patent number: 5041375
    Abstract: This invention relates to a method for producing carnitine comprising contacting, in a reaction medium, carnitinenitrile with (A) a nitrilase capable of hydrolyzing carnitinenitrile to form carnitine or (B) a microorganism containing said nitrilase.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: August 20, 1991
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kiyoshi Nakayama, Haruo Honda, Yukie Ogawa, Tetsuo Ohta, Tatsuya Ozawa
  • L-aminoacylases
    Patent number: 4745067
    Abstract: L-aminoacylases S.sub.1 and S.sub.2 derived from actinomycetes and having physicochemical characteristics such that it is a L-aminoacylase which acts on a N-acyl-L-amino acid to give a L-amino acid, its substrate profile is wide, and it acts not only on a N-acyl derivative of a natural L-amino acid, but also on a N-acyl derivative of a synthetic L-amino acid, while it does not act on a N-acyl-D-amino acid, a DL-N-acetyl-.alpha.methylbenzylamine and a N-acetyl-D-glucosamine, etc.
    Type: Grant
    Filed: April 29, 1986
    Date of Patent: May 17, 1988
    Assignees: Microbial Chemistry Research Foundation, Banyu Pharmaceutical Co., Ltd.
    Inventors: Hamao Umezawa, Tomio Takeuchi, Toshiharu Nagatsu, Masa Hamada, Shuichi Iwadare, Ikuo Matsumoto, Hajime Morishima
  • Process for the production of 7.alpha.-methoxycephalosporin derivatives
    Patent number: 4410626
    Abstract: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: October 18, 1983
    Assignee: Yamanouchi Pharmaceutical Co. Ltd.
    Inventors: Hiroshi Gushima, Shunichi Watanabe, Takeshi Saito, Toshio Sasaki, Hideo Eiki, Yoshihiko Oka, Takashi Osono
  • Process for preparing tunicamycin
    Patent number: 4336333
    Abstract: Tunicamycin is produced by the cultivation of Streptomyces chartreusis Calhoun and Johnson, 1956, NRRL 12338. Methods of recovering tunicamycin and for separating and isolating individual factors A.sub.1, A.sub.2, B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1 and D.sub.2 from tunicamycin complex are described.
    Type: Grant
    Filed: March 13, 1981
    Date of Patent: June 22, 1982
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn, LaVerne D. Boeck
  • Microbiological modification of antibiotic A23187 esters
    Patent number: 4287302
    Abstract: Cultivation of Streptomyces chartreusis NRRL 11407 in the presence of antibiotic A23187 methyl ester produces 16-hydroxy A23187 methyl ester, 16-hydroxy-N-demethyl A23187 methyl ester, and N-demethyl A23187 methyl ester. Hydrolysis of the products affords the corresponding free acids which form dimeric complexes with divalent cations.
    Type: Grant
    Filed: July 30, 1980
    Date of Patent: September 1, 1981
    Assignee: Eli Lilly and Company
    Inventors: Bernard J. Abbott, David S. Fukuda
  • Microbiological modification of antibiotic A23187 esters
    Patent number: 4247703
    Abstract: Cultivation of Streptomyces chartreusis NRRL 11407 in the presence of antibiotic A23187 methyl ester produces 16-hydroxy A23187 methyl ester, 16-hydroxy-N-demethyl A23187 methyl ester, and N-demethyl A23187 methyl ester. Hydrolysis of the products affords the corresponding free acids which form dimeric complexes with divalent cations.
    Type: Grant
    Filed: December 20, 1978
    Date of Patent: January 27, 1981
    Assignee: Eli Lilly and Company
    Inventors: Bernard J. Abbott, David S. Fukuda
  • Process for preparing tunicamycin
    Patent number: 4237225
    Abstract: Tunicamycin is co-produced with antibiotic A-23187 by the cultivation of Streptomyces chartreusis NRRL 3882. Methods of recovering tunicamycin and for separating and isolating individual factors A, B, C, and D from tunicamycin complex are described.
    Type: Grant
    Filed: December 1, 1978
    Date of Patent: December 2, 1980
    Assignee: Eli Lilly and Company
    Inventor: Robert L. Hamill