Streptomyces Lavendulae Patents (Class 435/899)
  • Cyclcic FR-900520 microbial biotransformation agent
    Patent number: 5221625
    Abstract: Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6963) ATCC No. 55230. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: June 22, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, Raymond F. White, Georgette Dezeny, Brian R. Petuch, George M. Garrity, Byron H. Arison, Amy M. Bernick
  • Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
    Patent number: 5198358
    Abstract: Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylated derivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: March 30, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Magda M. Gagliardi, Shieh-Shung T. Chen, George M. Garrity
  • Method for manufacturing 2-amino-2-deoxy-D-mannitol
    Patent number: 4894344
    Abstract: 2-amino-2-deoxy-D-mannitol is produced from a microorganism strain of the genus Streptomyces or a mutant strain thereof in improved yields and purity.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: January 16, 1990
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Makoto Sugiyama, Yoji Ezure, Nobutoshi Ojima, Kiyotaka Konno, Takashi Seto, Teruya Nakamura, Manabu Itoh
  • Novel saframycin A derivatives and process for producing the same
    Patent number: 4837149
    Abstract: Disclosed are compounds of the formula ##STR1## wherein R represents hydrogen or C.sub.1 -C.sub.4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC-(CH)NH.sub.2 -CH.sub.2 -R. When R is hydrogen, saframycin Y.sub.3 and when R is methyl, saframycin Y.sub.d-1 are produced.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: June 6, 1989
    Assignee: Tadashi Arai
    Inventors: Tadashi Arai, Yuzuru Mikami
  • A40A Efrotomycin-like antibiotic in fermentation broth
    Patent number: 4264607
    Abstract: There is disclosed a new antibiotic agent, A40A, produced by Streptomyces lavedulae MA-4758 (ATCC 31312) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, Vincent P. Gulla, Sheldon B. Zimmerman, Satoshi Omura, Ruiko Oiwa
  • Cultivating streptomyces to produce an esterase inhibitor
    Patent number: 4242453
    Abstract: A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: December 30, 1980
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
  • Process for the preparation of 2-hydroxymethyl-3,4,5-trihydroxy piperidine
    Patent number: 4198481
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy piperidine, or moranoline, is prepared by culturing a moranoline-producing strain of microorganism of the genus Streptomyces in an appropriate culture medium and thereafter isolating moranoline from the culture medium.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: April 15, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoji Ezure, Yoshiaki Yoshikuni, Masahiro Yagi