Streptomyces Sparogenes Patents (Class 435/905)
  • Antibiotics X-14889 A,C and D
    Patent number: 4672033
    Abstract: There is presented antibiotic compounds designated as Antibiotics X-14889 A, C and D of the formulas ##STR1## wherein (for X-14889A) R.sub.1 is methyl, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.4 is methyl and R.sub.5 is hydrogen or (for X-14889C) R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.4 is methyl and R.sub.5 is CO.sub.2 H or ##STR2## and the pharmaceutically acceptable salts thereof. The compounds exhibit antimicrobial activity and one of the compounds X-14889C also exhibits activity against Treponema hyodysenteriae (in vitro), Plasmodium berghei and as food efficiency enhancers in ruminants.Also presented is a process to produce the above compounds and another known component Antibiotic X-14889B.
    Type: Grant
    Filed: May 23, 1985
    Date of Patent: June 9, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, John Westley
  • Sparsomycin (S.sub.c -R.sub.s) derivative; pharmaceutical composition having anti-tumor activity
    Patent number: 4581360
    Abstract: The invention concerns novel sparsomycin (S.sub.c -R.sub.s) derivatives having superior cytostatic activity compared to sparsomycin itself. Said derivatives contain a lipophilic group R.sup.2, selected from C.sub.2 -C.sub.20 -alkyl, aryl, aralkyl and alkaryl, which is preferably n-octyl or benzyl.
    Type: Grant
    Filed: December 9, 1983
    Date of Patent: April 8, 1986
    Assignee: Stichting Katholieke Universiteit
    Inventors: Henricus C. J. Ottenheijm, Robertus M. J. Liskamp