Candida Albicans Patents (Class 435/922)
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Patent number: 7090857Abstract: The present invention relates to antigenic preparations comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, process for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccines, including but not limited to, the prophylaxis and treatment of allergy, as well as for modulating the immune response.Type: GrantFiled: March 22, 2002Date of Patent: August 15, 2006Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Dieter Farnow, Joachim Karle, Igor D. Poliakov, Ludmilla G. Ivanova
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Patent number: 7001776Abstract: This invention provides a novel device and method for preparing cytology slides. The device comprises a book-like form including an absorbent material and filter attached to the inside surface of a front cover and a cytology slide removeably attached to an inside surface of a back cover. A sample is removed from the body of a patient, placed in a liquid-based solution, and then on the filter. When the book-like form is closed, the sample is effectively transferred to the slide. The device can be modified so that a plurality of slides are prepared at the same time.Type: GrantFiled: April 4, 2001Date of Patent: February 21, 2006Assignee: Digene CorporationInventors: Gerson Botacini das Dores, Iwona Mielzynska-Lohnas, Eliane Taromaru, William J. Payne, Joseph P. Slattery, James G. Lazar
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Patent number: 6890729Abstract: This invention provides a novel device and method for preparing cytology slides. The device comprises a book-like form including an absorbent material and filter attached to the inside surface of a front cover and a cytology slide removeably attached to an inside surface of a back cover. A sample is removed from the body of a patient, placed in a liquid-based solution, and then on the filter. When the book-like form is closed, the sample is effectively transferred to the slide.Type: GrantFiled: May 22, 2002Date of Patent: May 10, 2005Assignee: Digene CorporationInventors: Iwona Mielzynska, Jay Payne, James Lazar
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Patent number: 6627408Abstract: The present invention provides high throughput screening Systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.Type: GrantFiled: October 11, 2002Date of Patent: September 30, 2003Assignee: Cytokinetics, Inc.Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
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Patent number: 6468760Abstract: The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.Type: GrantFiled: November 28, 2000Date of Patent: October 22, 2002Assignee: Cytokinetics, Inc.Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
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Patent number: 6436662Abstract: This invention provides a novel device and method for preparing cytology slides. The device comprises a book-like form including an absorbent material and filter attached to the inside surface of a front cover and a cytology slide removeably attached to an inside surface of a back cover. A sample is removed from the body of a patient, placed in a liquid-based solution, and then on the filter. When the book-like form is closed, the sample is effectively transferred to the slide.Type: GrantFiled: April 4, 2000Date of Patent: August 20, 2002Assignee: Digene CorporationInventors: Iwona Mielzynska, Jay Payne, James Lazar
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Patent number: 6379678Abstract: The present invention relates to antigenic preparations comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, processes for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccines, including but not limited to, the prophylaxis and treatment of allergy, as well as for modulating the immune response.Type: GrantFiled: May 15, 1998Date of Patent: April 30, 2002Assignee: Boehringer Indgelheim Vetmedica GmbHInventors: Dieter Farnow, Joachim Karle, Igor D. Poliakov, Ludmilla G. Ivanova
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Patent number: 6333164Abstract: There can be provided a fungal antigen which is an insoluble fraction obtainable from fungal cells of which cell wall has been substantially removed or at least partially removed; a process for producing the same; a nucleic acid encoding the fungal antigen; a biologic product containing the fungal antigen; a method of stimulating immunological responses by using the biologic product; a method of suppressing allergic reaction to fungi in a vertebrate; and a method for diagnosing a disease caused by fungi in a vertebrate.Type: GrantFiled: March 4, 1999Date of Patent: December 25, 2001Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Shigetoshi Mizutani, Masahiro Endo, Ikunoshin Kato
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Patent number: 6300140Abstract: A slide having a portion thereof provided with transparent adhesive which adheres to a test sample. The slide and adhesive may be transparent. Specific types of infection and particularly fungal infections can be detected in the test sample using immunotest-methods. In a special embodiment the adhesive slide is fashioned with a peripheral lip or well to contain a test sample and a reagent.Type: GrantFiled: July 7, 1999Date of Patent: October 9, 2001Assignee: Leonard BloomInventors: Howard N. Robinson, Francisco A. Tausk, Bruce S. Bochner, Neil F. Martin
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Patent number: 6284480Abstract: The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.Type: GrantFiled: April 3, 2000Date of Patent: September 4, 2001Assignee: Cytokinetics, Inc.Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
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Patent number: 6136953Abstract: A substantially pure DNA comprising a sequence encoding a smooth muscle cell LIM (SmLIM) polypeptide, methods of diagnosing vascular injury by detecting a decrease in SmLIM gene expression, and methods of inhibiting vascular smooth muscle cell proliferation.Type: GrantFiled: April 2, 1998Date of Patent: October 24, 2000Assignee: President and Fellows of Harvard CollegeInventors: Mu-En Lee, Edgar Haber, Mukesh Jain, Shaw-Fang Yet
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Patent number: 5998181Abstract: The present invention relates to a fermentation process for preparing xylitol with high productivity and high yield using a novel strain of Candida tropicalis, more specifically, for preparing xylitol under optimal fermentation conditions for maximum xylitol production by optimizing the composition of medium containing xylose and the environmental conditions of culture such as pH, temperature and DO concentration.Type: GrantFiled: March 13, 1998Date of Patent: December 7, 1999Assignee: Bolak Co., Ltd.Inventors: Sang Yong Kim, Deok Kun Oh, Soo Ryun Jung
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Patent number: 5994149Abstract: A slide having a portion thereof provided with transparent adhesive which adheres to a test sample. The slide and adhesive may be transparent. Specific types of infection and particularly fungal infections can be detected in the test sample using immunotest-methods. In a special embodiment the adhesive slide is fashioned with a peripheral lip or well to contain a test sample and a reagent.Type: GrantFiled: October 1, 1997Date of Patent: November 30, 1999Assignee: Leonard BloomInventors: Howard N. Robinson, Francisco Tausk, Bruce Bochner, Neil F. Martin
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Patent number: 5789191Abstract: The invention provides a cosmetic or dermatological method for detecting and/or selectively quantifying individual microorganisms, and/or whole groups of microorganisms, which are present on human or animal skin, comprising the steps ofremoving a sample of the microflora of the human or animal skin,treating the sample with a deinhibiting medium, adding the treated sample to a culture medium which exhibits favorable growth conditions for a defined group of microorganisms but unfavorable growth conditions for other microorganisms, to produce a selective culture, and incubating the selective culture over a sufficiently long period of time, to allow only the group of microorganisms for which the culture medium exhibits favorable growth conditions the opportunity to multiply, in association with metabolic products, in particular CO.sub.Type: GrantFiled: February 21, 1996Date of Patent: August 4, 1998Assignee: Beiersdorf AGInventors: Bianca Mayer, Gerhard Sauermann, Bernd Traupe, Florian Wolf
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Patent number: 5763169Abstract: Nucleic acid probes and primers are described for detecting fungi that cause disease in humans and animals, as well as spoilage of food and beverages. These probes can detect rRNA, rDNA or polymerase chain reaction products from a majority of fungi in clinical, environmental or food samples. Nucleic acid hybridization assay probes specific for Aspergillus fumigatus, Blastomyces dermatitidis, Candida albicans, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Aspergillus flavus, Aspergillus glaucus, Aspergillus niger, Aspergillus terreus, Candida glabrata, Candida guilliermondii, Candida kefyr, Candida krusei, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Pseudallescheria boydii, and Sporothrix schenckii are also described.Type: GrantFiled: January 13, 1995Date of Patent: June 9, 1998Assignee: Chiron Diagnostics CorporationInventors: Gurpreet S. Sandhu, Bruce C. Kline
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Patent number: 5756321Abstract: Methods for the enzyme catalyzed acylation of primary and secondary alcohols using an enol ester as the acyl donor are described. The acylation occurs in organic media, and is enantioselective for racemic or prochiral alcohols. The reaction is irreversible, and produces unreactive by-products.Type: GrantFiled: February 20, 1996Date of Patent: May 26, 1998Assignee: Hoechst AktiengesellschaftInventors: Manfred Schudok, Gerhard Kretzschmar
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Patent number: 5741662Abstract: The present invention provides specific binding solid phase assay methods and kits for the detection of the presence or absence of a microorganism by directly staining the microorganism and specifically capturing the stained microorganism on a solid support. The methods find particular utility in the detection of Candida. The methods may simultaneously detect the presence or absence of multiple microorganisms.Type: GrantFiled: December 18, 1995Date of Patent: April 21, 1998Assignee: Quidel CorporationInventors: Randall D. Madsen, Lorraine S. Bautista, Jan W. Pawlak, Allan D. Pronovost
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Patent number: 5707802Abstract: Nucleic acid probes and primers are described for detecting fungi that cause disease in humans and animals, as well as spoilage of food and beverages. These probes can detect rRNA, rDNA or polymerase chain reaction products from a majority of fungi in clinical, environmental or food samples. Nucleic acid hybridization assay probes specific for Acremonium sp., Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus glaucus, Aspergillus nidulans, Aspergillus niger, Aspergillus ochraceus, Aspergillus terreus, Aspergillus unguis, Aspergillus ustus, Beauveria sp., Bipolaris sp., Blastoschizomyces sp., Blastomyces dermatitidis, Candida albicans, Candida glabrata, Candida guilliermondii, Candida kefyr, Candida krusei, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Chrysosporium sp., Cladosporium sp., Coccidioides immitis, Cryptococcus neoformans var gattii serotype B, Cryptococcus neoformans serotype A, Cryptococcus laurentii, Cryptococcus terreus, Curvularia sp., Fusarium sp.Type: GrantFiled: May 5, 1995Date of Patent: January 13, 1998Assignee: Ciba Corning Diagnostics Corp.Inventors: Gurpreet S. Sandhu, Bruce C. Kline
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Patent number: 5686248Abstract: A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organisms, particularly the heat shock protein hsp 90 of Saccharomyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.Type: GrantFiled: June 28, 1996Date of Patent: November 11, 1997Assignee: The Victoria University of ManchesterInventors: James Peter Burnie, Ruth Christine Matthews
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Patent number: 5658726Abstract: A method for constructing a cDNA probe for use in detecting in a sample, under conditions of predetermined stringency, a target organism belonging to a strain of fungal microorganisms, and not detecting in the sample under such conditions a reference microorganism or any prokaryotic microorganism, includes the steps of determining a nucleotide base sequence in a variable region of small subunit ribosomal RNA from the target organism, the variable region being a region of the small subunit ribosomal RNA that is poorly conserved among eukaryotes and having no corresponding region in prokaryotes; comparing the nucleotide base sequence in the corresponding region of small subunit ribosomal RNA from the reference microorganism, and selecting as a useful probe site a subsequence within the determined sequence; and synthesizing a cDNA complementary to the useful probe site, the cDNA being the probe. Nucleic acid probes are constructed according to the disclosed method.Type: GrantFiled: March 27, 1992Date of Patent: August 19, 1997Assignee: Amoco CorporationInventor: Jeffrey F. Lemontt
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Patent number: 5604119Abstract: The present invention relates to a process for preparing a triglyceride, comprising reacting glycerol with a polyunsaturated fatty acid having at least 20 carbon atoms and at least three double bonds or a C.sub.1-4 alkyl ester thereof, for a reaction time in the range of 24-48 hours at a temperature between 40.degree. and 80.degree. C. in the presence of a mixture of lipase A and lipase B obtained from Candida antarctica which is immobilized, to form (i) the triglyceride and (ii) water or a C.sub.1-4 alcohol, while removing the water or the C.sub.1-4 alcohol during the reaction, and recovering the triglyceride.Type: GrantFiled: January 23, 1995Date of Patent: February 18, 1997Assignees: Novo Nordisk A/S, LYSI HFInventors: Gudmundur G. Haraldsson, Hanne Svanholm, Baldur Hjaltason
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Patent number: 5449612Abstract: The present invention relates to a method of determining, assaying and identifying strains of Candida and pathogenic strains belonging to species Torulopsis glabrata by means of chromogenic substrates of monoamino acid or peptide type without the isolation of the strains to be identified.Type: GrantFiled: November 19, 1991Date of Patent: September 12, 1995Assignee: SerbioInventors: Jean-Pierre Lepargneur, Genevieve Contant epouse Pussard, Jean-Luc Martinoli, Gerard Quentin
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Patent number: 5405745Abstract: Isolated nucleic acid molecules capable of hybridizing to sequences of Candida albicans along with methods utilizing such probes for the detection of Candida albicans in clinical and other biological samples.Type: GrantFiled: December 17, 1991Date of Patent: April 11, 1995Assignee: E. R. Squibb & Sons, Inc.Inventors: Jessica A. Gorman, Catherine A. Bingham
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Patent number: 5374423Abstract: Cytokine receptors for tumor necrosis factor e which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries are provided.Type: GrantFiled: August 27, 1993Date of Patent: December 20, 1994Assignee: Board of Regents, The University of Texas SystemInventors: Gary R. Klimpel, David W. Niesel
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Patent number: 5294546Abstract: A method of producing a growth promoting factor for Bifidobacterium species from lactose which comprises contacting lactose with resting cells of a lactose-utilizing yeast strain having activity to rearrange lactose to galacto-oligosaccharides.Type: GrantFiled: November 29, 1991Date of Patent: March 15, 1994Assignee: Unitika Ltd.Inventors: Munehiko Dombou, Isao Tomioka, Ryoichi Tsurutani, Senji Kitabatake, Hiroshi Nakajima
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Patent number: 5288639Abstract: A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organisms, particularly the heat shock protein hsp 90 of Sacchromyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.Type: GrantFiled: March 14, 1991Date of Patent: February 22, 1994Assignee: The Victoria University of ManchesterInventors: James P. Burnie, Ruth C. Matthews
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Patent number: 5270038Abstract: Cytokine receptors for tumor necrosis factor .alpha. which are found on microorganisms may, if bound with exogenous TNF.alpha., enhance the response of natural killer cells activated by the microorganisms, or increase TNF.alpha. production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF.alpha. have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries including vaccines with increased efficacy are provided.Type: GrantFiled: January 23, 1992Date of Patent: December 14, 1993Assignee: Board of Regents, The University of Texas SystemInventors: Gary R. Klimpel, David W. Niesel
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Patent number: 5081033Abstract: Methods and compositions are disclosed for the rapid identification of fungal pathogens. In a preferred method, a sample of human body fluid is obtained and subjected to analysis comprising inoculating a nutritive medium, incubating said inoculum for such time and temperature as is necessary for visible fungal colony formation, thereafter plating a sample of said visible fungi on miniature culture plates for example having the dimensions of about 33.times.75.times.5 millimeters, said plates containing differential fungal media, and thereafter identifying funal pathogens in a manner consistent with said medium selected.Type: GrantFiled: July 14, 1986Date of Patent: January 14, 1992Assignee: Wadley Technologies, Inc.Inventors: Gordon L. Dorn, William H. Fleming, Karen L. Knezek
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Patent number: 5077206Abstract: The invention provides a process for preparing L-rhamnose by hydrolyzing a rhamnosidic bond of a glycoside having rhamnose in a terminal position, by enzymatically hydrolyzing the glucoside with an enzyme combination comprising biological structural material degrading enzyme and a naringinase preparation which has a higher rhamnosidase activity than beta-glucosidase activity. Preferably the enzyme combination having rhamnosidase activity together with additional enzyme activity is a selected partially purified enzyme preparation having high rhamnosidase activity and low glucosidase activity together with biological structural material degrading activity. More preferably the additional enzyme activity is derived from an enzyme of the group consisting of protease, lipase, pectinase, cellulase and hemicellulase.Type: GrantFiled: November 21, 1988Date of Patent: December 31, 1991Assignee: Unilever Patent Holdings B.V.Inventors: Peter S. J. Cheetham, Michael A. Quail
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Patent number: 4981794Abstract: A method is provided for preparing D(-)-.beta.-hydroxyisobutyric acid by fermentation employing the method and/or ethyl esters of isobutyric acid, the methyl and/or ethyl esters of methacrylic acid, isobutyl isobutyrate and/or isobutyl methacrylate as the substrate and a microorganism of the genus Candida and other fungi. In an alternative method, the isolated cells of the various microorganisms are employed with one or mixtures of the above substrates.Type: GrantFiled: October 19, 1987Date of Patent: January 1, 1991Assignee: E. R. Squibb & Sons, Inc.Inventors: Robert S. Robison, Laszlo J. Szarka
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Patent number: 4874695Abstract: Rapid identification of different species of microorganism selected from fungi and yeast like algae is accomplished by culturing the microorganism for several hours under normal conditions on a non-inhibitory mycological medium which stimulates the microorganism to make characteristic enzymes by which the microorganism can be identified, distributing the culture (in suspension) onto several supports containing different substrates which are capable of reacting with the enzymes so produced by the different species of microorganisms; and rapidly incubating the admixture to produce a distinctly colored or colorable reaction product.Type: GrantFiled: February 21, 1985Date of Patent: October 17, 1989Assignee: American Home Products Corp.Inventor: David H. Pincus
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Patent number: 4847128Abstract: Methods and compositions are disclosed for the rapid identification of fungal pathogens. In a preferred method, a sample of human body fluid is obtained and subjected to analysis comprising inoculating a nutritive medium, incubating said inoculum for such time and temperature as is necessary for visible fungal colony formation, thereafter plating a sample of said visible fungi on miniature culture plates for example having the dimensions of about 33.times.75.times.5 millimeters, said plates containing differential fungal media, and thereafter identifying fungal pathogens in a manner consistent with said medium selected.Type: GrantFiled: July 14, 1986Date of Patent: July 11, 1989Assignee: Wadley Technologies, Inc.Inventors: Gordon L. Dorn, William H. Fleming, Karen L. Knezek
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Patent number: 4735901Abstract: Candida albicans has been transformed by the insertion of a plasmid comprising a fragment of DNA from Candida albicans containing the intact ADE 2 gene.Type: GrantFiled: January 14, 1985Date of Patent: April 5, 1988Assignee: E. R. Squibb & Sons, Inc.Inventors: Myra B. Kurtz, Donald R. Kirsch
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Patent number: 4379841Abstract: The disclosure relates to a culture medium containing as a sole carbon source 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid or a mixture thereof, and to an assimilation test for identifying yeasts utilizing such a culture medium.Type: GrantFiled: October 2, 1981Date of Patent: April 12, 1983Assignee: Abbott LaboratoriesInventor: Billy H. Cooper
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Patent number: 4182753Abstract: A Sarcoma 180 tumor growth inhibiting glycoprotein material produced extracellularly from Candida albicans is provided. The inhibitor material is effective to arrest Sarcoma 180 tumor angiogenesis thereby causing tumor regression. The preferred inhibitor material is an extracellular glycoprotein produced from Candida albicans SA#1 (CBS 5736) cultured in a glucose containing chemical medium with a filtrate of the growth medium precipitated with ethanol. Dosage innoculations of the precipitate into the peritoneal cavities of Sarcoma 180 tumor infected mice effect substantial tumor regression.Type: GrantFiled: March 29, 1978Date of Patent: January 8, 1980Inventor: Cora G. Saltarelli