Lipid, Cholesterol, Or Triglyceride Standard Or Control Patents (Class 436/13)
  • Patent number: 10272098
    Abstract: The present invention provides drug delivery compositions that allow for immediate and/or sustained release of a therapeutic agent contained within the system. The present invention also provides drug delivery compositions that preserve the stability of the therapeutic agent contained within during the sustained release. The present invention further provides a method of treating, ameliorating, or preventing an inflammation-related disease or disorder in a subject using the compositions of the invention.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 30, 2019
    Assignee: Drexel University
    Inventors: Yinghui Zhong, Zhiling Zhang
  • Patent number: 9849160
    Abstract: The present invention generally relates to compositions and methods for treatment of subjects having or at risk of cancer or other conditions. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: December 26, 2017
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9585829
    Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, treatment of skin, and improving the appearance of skin, e.g., medically or cosmetically. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: March 7, 2017
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9480642
    Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, e.g., for affecting mood states. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 1, 2016
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 8969088
    Abstract: A substrate mimicking intercellular lipids in stratum corneum consisting of a substrate and a lipid membrane formed on the substrate, wherein the lipid membrane is formed from ceramide, palmitic acid and cholesterol, and the ceramide, palmitic acid and cholesterol are present at a mass ratio of 20-70%:10-60%:20-40% (ceramide:palmitic acid:cholesterol).
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: March 3, 2015
    Assignee: Shiseido Company, Ltd.
    Inventors: Takuya Saiwaki, Takashi Oka, Yuichiro Mori, Toyoko Imae, Xiaojuan Wang, Masaki Ujihara
  • Patent number: 8845415
    Abstract: In various embodiments, players around the casino may predict cards to be dealt in a game of blackjack.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: September 30, 2014
    Assignee: CFPH, LLC
    Inventors: Howard W. Lutnick, Dean P. Alderucci, Geoffrey M. Gelman, Kevin Burman
  • Patent number: 8772034
    Abstract: A control solution packet for calibrating a bodily fluid sampling device includes a container, a control solution pressurized within the container, and a membrane for covering and sealing the container. The control solution can be pressurized before or during calibration so as to ensure the appropriate amount of control solution is delivered to the bodily fluid sampling device. The control solution is manufactured to have a viscosity that controls delivery of the control solution to the device. The membrane is permeable by a piercing device of the bodily fluid sampling device and seals around the piercing device during calibration. In another aspect, the container is in the form of a capsule or dosing attachment that contains the control solution along with a sponge-like material.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: July 8, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Juergen Rasch-Menges, Paul Jansen
  • Publication number: 20140017793
    Abstract: The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 16, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Scott M. Goldman, Julie A. Neidich
  • Patent number: 8563315
    Abstract: A Mixture of substances is provided for precise calibration of the mass scale of mass spectrometers equipped with ion sources that operate at atmospheric pressure (AP) with ionization of the analyte molecules, for example by APCI (chemical ionization), or by APPI (photoionization), often at high temperatures of up to 470° C. Out of physical reasons, the mass scale of any time-of-flight mass spectrometer deviates in the lower mass range from the theoretical relation between charge-related mass m/z and flight time t. A closely spaced arrangement of low mass calibration reference points is necessary if high mass accuracy is to be achieved for substances of low molecular weight. APCI and APPI sources are increasingly used in time-of-flight mass spectrometers with orthogonal ion injection (OTOF MS) for the detection of non-polar and weakly polar compounds, in particular, for analyte molecules with relatively low molecular weights.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: October 22, 2013
    Assignee: Bruker Daltonik GmbH
    Inventors: Thomas Zey, Jan Willmann
  • Publication number: 20130144114
    Abstract: The invention relates to a non-invasive diagnostic method of endometrial receptivity which includes collecting and comparing lipid biomarker patterns to reference lipidomic biomarkers, particularly prostaglandins PGE2 and/or PGF2?. The method is especially applicable for determining status fertility of a mammalian female, preferably, a woman.
    Type: Application
    Filed: January 21, 2011
    Publication date: June 6, 2013
    Applicant: Equipo IVI Investigación S.L.
    Inventors: Carlos Simón Vallés, Antonio Pellicer Martínez, Óscar Berlanga Atienza
  • Patent number: 8386187
    Abstract: Methods, reports and systems for generating insulin resistance indexes for assessing decreased insulin sensitivity and/or levels of insulin resistance using a plurality of different measured lipoprotein particle parameters.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: February 26, 2013
    Assignee: LipoScience, Inc.
    Inventor: James D. Otvos
  • Patent number: 8263413
    Abstract: Methods for accurately comparing the levels of ionizable lipids in two cell populations that differ in some respect from each other using mass spectroscopy and isotopic labeling are provided. The methods can be used to identify a change in a lipid of interest in response to a cellular, chemical, genetic, or environmental change to the cell population (i.e., a lipid response to a cell perturbation). The change in the lipid of interest can be a change in composition, rate of synthesis, and/or location of the lipid.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: September 11, 2012
    Inventor: Andrew S Hansen
  • Patent number: 8246442
    Abstract: A game of chance is disclosed that looks like a multi-line gaming machine having a matrix of rows and columns of positions for displaying slot symbols or cards to a player. A player wagers to play one or more games but the actual pay lines are dynamically determined by events that occur during the course of game play, not before. Per the teaching of the invention a number of bonus pay lines and their routing are dynamically determined during the course of game play of slots or cards dependent on choices made by a player during game play.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: August 21, 2012
    Inventor: Robert P Barrie
  • Patent number: 8183048
    Abstract: A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of generating a detectable signal, wherein the detectable signal changes in a parameter representative of an integrity of the sterol superlattice formation; and detecting and/or measuring disruption of the sterol superlattice formation, wherein the disruption is caused by the insertion of the antioxidant into membranes and thereby screening the antioxidant for potency and/or toxicity.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: May 22, 2012
    Assignee: Temple University- Of the Commonwealth System of Higher Education
    Inventors: Parkson Lee-Gau Chong, Michelle Olsher, Su-In Yoon
  • Patent number: 8183046
    Abstract: A method for preparing a composition that includes selecting a pH of the composition; selecting a first buffer with a negative temperature coefficient; selecting a second buffer with a positive temperature coefficient; and forming the composition comprising the first buffer and the second buffer. The composition has an average temperature coefficient, ?pH/?T(Ta,Tb)?1×10?3 pH-unit/K and a ?pH(Ta,Tb)?0.31 pH-unit for Ta=4 K and Tb=313 K.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: May 22, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Yi Lu, Hee-Jung Hwang, Nathan Sieracki, Dewain Garner
  • Patent number: 8071384
    Abstract: Control and calibration solutions are described that provide control and calibration data that is recognized by a test meter allowing the meter to segregate the control and calibration data from regular test data. Recognition and segregation of the control and calibration data can occur automatically with no additional input from the meter's user. Methods for use of the solutions are also provided.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: December 6, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: David W. Burke, Terry A. Beaty, Lance S. Kuhn, Vladimir Svetnik
  • Patent number: 8066958
    Abstract: A control solution packet for calibrating a bodily fluid sampling device includes a container, a control solution pressurized within the container, and a membrane for covering and sealing the container. The control solution can be pressurized before or during calibration so as to ensure the appropriate amount of control solution is delivered to the bodily fluid sampling device. The control solution is manufactured to have a viscosity that controls delivery of the control solution to the device. The membrane is permeable by a piercing device of the bodily fluid sampling device and seals around the piercing device during calibration. In another aspect, the container is in the form of a capsule or dosing attachment that contains the control solution along with a sponge-like material.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 29, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Juergen Rasch-Menges, Paul Jansen
  • Patent number: 8030081
    Abstract: A reagent for fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable to a rapid and convenient autoanalyzer, is provided. A method for quantitatively determining cholesterol in small, dense LDLs in a sample is further provided. The method includes first step of eliminating lipoproteins other than small, dense LDLs in a sample in the presence of cholesterol esterase and 0.05 g/L to 1.0 g/L of a surfactant that acts on the lipoproteins other than small, dense LDLs, and a second step of quantitatively determining cholesterol in small dense LDLs that remain after the first step.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: October 4, 2011
    Assignee: Denka Seiken Co., Ltd.
    Inventor: Yasuki Itoh
  • Patent number: 8026099
    Abstract: The present invention relates to compositions and methods for the early detection or monitoring of neurodegenerative diseases and neurological disorders including Alzheimer's disease. The invention provides biomarkers based on lipid profiles of biological samples and methods for using the biomarkers for the detection of neurodegenerative diseases and neurological disorders.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: September 27, 2011
    Assignee: Washington University
    Inventor: Xianlin Han
  • Patent number: 8003402
    Abstract: The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual concentration of LMWH is further provided.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: August 23, 2011
    Assignee: Active BioMaterials, LLC
    Inventors: Ralph Yamamoto, Yumi Kim
  • Patent number: 7981677
    Abstract: Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: July 19, 2011
    Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company
    Inventors: William B. Allen, Bo Shen, Mitchell C. Tarczynski, Mark E. Williams, Peizhong Zheng, Gan-Yuan Zhong
  • Patent number: 7851224
    Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: December 14, 2010
    Assignee: The Regents of the University of California
    Inventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
  • Patent number: 7846735
    Abstract: Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: December 7, 2010
    Assignee: General Electric Company
    Inventors: Anton Beletskii, Liming Lu, Jason William Castle
  • Publication number: 20100291687
    Abstract: A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system comprising a sterol superlattice formation capable of generating a detectable signal, wherein the detectable signal changes in a parameter representative of an integrity of the sterol superlattice formation; and detecting and/or measuring disruption of the sterol superlattice formation, wherein the disruption is caused by oxidation of sterol upon contacting sterol with a prooxidant and the antioxidant and thereby screening the antioxidant for potency and/or toxicity.
    Type: Application
    Filed: July 25, 2008
    Publication date: November 18, 2010
    Applicant: TEMPLE UNIVERSITY- OF THE COMMONWEATH SYSTEM OF HIGHER EDUCATION
    Inventors: Parkson Lee-Gau CHONG, Michelle OLSHER, Su-In YOON
  • Patent number: 7820444
    Abstract: Method as well a kit for the performance of the method for the investigation of biological samples from a mammal for at least one component, wherein the method includes the following steps: (a) Administering at least one marker substance to a mammal; (b) Waiting for a length of time which is sufficient for the at least one marker substance to reach the location of sample removal; (c) Removing a biological sample from the mammal; (d) Investigating the biological sample for the presence and/or amount of at least one marker substance or a derivative thereof; and, if the at least one marker substance or the derivative thereof is detectable in the biological sample; (e) Investigating the biological sample for an analyte.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: October 26, 2010
    Inventors: Ruprecht Keller, Gisela Gauchel
  • Patent number: 7820108
    Abstract: The present invention includes a method and apparatus for monitoring drug compliance by detecting markers, such as odors, upon exhalation by a patient after medication is taken, wherein such markers result either directly from the medication itself or from an additive combined with the medication. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial noses” or “electronic noses,” to non-invasively monitor compliance. The invention further includes a reporting system capable of tracking compliance (remote or proximate) and providing the necessary alerts.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: October 26, 2010
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Samsun Lampotang, Richard J. Melker, David N. Silverman
  • Patent number: 7759130
    Abstract: An object of the present invention is to quantitate with good accuracy, furthermore, quantitate absolutely, one or a plurality of biological molecules in a sample such as a tissue, a biological fluid, a cell, a cell organ or protein complex. By adding a metabolically isotope labeled biological molecule as an internal standard substance and measuring with a mass spectrometer, quantitating with good accuracy one or a plurality of target molecules in a sample has become possible. In addition, by performing waveform separation processing during mass analysis, a highly accurate quantitative analysis method of mass analysis is provided.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: July 20, 2010
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Yoshiya Oda, Yasushi Ishihama, Tsuyoshi Tabata
  • Publication number: 20100144042
    Abstract: The invention concerns a method for automatically differentiating between a sample liquid and a control liquid especially within the context of analytical measuring systems, wherein the presence of a special property of the control liquid and/or at least two criteria are used for the differentiation. In addition the invention concerns appropriate control liquids that are suitable for the new method.
    Type: Application
    Filed: February 15, 2010
    Publication date: June 10, 2010
    Inventors: Guenter Frey, Carina Horn, Otto Gaa, Hans Kintzig, Hans-Ruediger Murawski
  • Patent number: 7713744
    Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: May 11, 2010
    Assignee: The Regents of the University of California
    Inventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
  • Patent number: 7638336
    Abstract: The present invention relates to an assay for determining the levels of sterols, stanols, steryl esters, fatty acid derivatives and combinations thereof in a starch-containing food product. The assay is particularly useful in supporting product health and/or nutritional claims in manufacturing products intended for human or animal consumption. The present invention describes a method for extracting sterols related compounds and uses as an internal standard a steryl ester, preferably cholesteryl oleate. By using the present extraction technique the process enables the recovery of substantially all of the sterol related compound in the sample.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: December 29, 2009
    Assignee: General Mills, Inc.
    Inventors: Daniel J. Lewandowski, David W. Plank, Jonathan W. Devries
  • Patent number: 7604952
    Abstract: A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages are, first, the non-acute stage, which is either asymptomatic coronary artery disease or stable angina, second, the acute stage known as unstable angina, and, third, the acute stage known as acute myocardial infarction. The diseased state (as opposed to the non-diseased state) is indicated by the clinically significant presence of a first marker in a sample from the patient. The presence of one of the two acute stages, unstable angina or acute myocardial infarction, is indicated by the clinically significant presence of a second marker in a sample from the patient. The presence of the more severe acute stage known as acute myocardial infarction is indicated by the clinically significant presence of a third marker in a sample from the patient.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: October 20, 2009
    Assignee: Leuven Research & Development VZW
    Inventors: Paul N. Holvoet, Désiré J. Collen
  • Patent number: 7510880
    Abstract: A method for determination of at least one of the lipid species in a biological sample comprising subjecting the sample to lipid extraction to obtain a lipid extract and subjecting the resulting lipid extract to multidimensional electrospray ionization mass spectrometry using either precursor ion or neutral loss scanning (or both) of all naturally occurring aliphatic chains, lipid fragments and precursor ions leading to observed fragments to generate a multidimensional matrix whose contour densities provides structural and quantitative information directly without chromatography. A method for determination of lipid content and/or lipid molecular species composition and quantity directly from lipid extracts of a biological sample comprising subjecting said lipid extract to electrospray ionization multidimensional mass spectrometry by comparisons to standards and algorithms described herein.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: March 31, 2009
    Inventors: Richard W. Gross, Xianlin Han
  • Publication number: 20090029473
    Abstract: The present invention relates to compositions and methods for the early detection or monitoring of neurodegenerative diseases and neurological disorders including Alzheimer's disease. The invention provides biomarkers based on lipid profiles of biological samples and methods for using the biomarkers for the detection of neurodegenerative diseases and neurological disorders.
    Type: Application
    Filed: July 25, 2008
    Publication date: January 29, 2009
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventor: Xianlin Han
  • Patent number: 7476542
    Abstract: In accordance with one or more embodiments of the present invention, a method is provided that comprises determining a first strategy for play of a game and a second strategy for play of the game, selecting at least one final outcome of the game that cannot result from the first strategy, and increasing a payout ratio associated with the selected at least one final outcome.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: January 13, 2009
    Assignee: Walker Digital, LLC
    Inventors: Jay S. Walker, James A. Jorasch, Magdalena M. Fincham, Geoffrey M. Gelman
  • Patent number: 7416895
    Abstract: This invention is directed to a data base which contains data for HDL2b, LDL IIIa & LDL IIIb and LDL IVb subclasses all in mg/Dl and which is correlated to cardiovascular disease.
    Type: Grant
    Filed: April 12, 2003
    Date of Patent: August 26, 2008
    Assignee: Berkeley Heartlab, Inc.
    Inventors: David Shewmake, Frank Ruderman, Christopher Boggess, Faith Clendenen
  • Patent number: 7285297
    Abstract: The present invention is a composition comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. The present invention is also a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: October 23, 2007
    Assignee: Archer-Daniels-Midland Company
    Inventors: Doyle H. Waggle, Susan M. Potter, Edna C. Henley
  • Patent number: 7259018
    Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: August 21, 2007
    Assignee: The Regents of the University of California
    Inventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
  • Patent number: 7244618
    Abstract: The invention describes materials useful for calibrating methods, and standards, calibration verification, linearity, and quality control materials for any method used to detect lipids and/or lipoproteins. This invention describes methods for producing, and compositions produced thereby, stable lipid controls, standards, and reagents including a stabilizing amount of TDPA, and further including a known amount of a substantially pure constituent of interest, including total cholesterol (CHOL), triglycerides (TRIG), high density lipoprotein (HDL), APO lipoprotein A (APO-A), APO Lipoprotein B (APO-B), low density lipoprotein (LDL), apolipoprotein a Lp(a) and other lipoprotein moieties useful for calibrating, standardizing, verifying, quality control, and the like, relating to use of an instrument for assessing the level of such constituents in a sample.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: July 17, 2007
    Assignee: Maine Standards Company, LLC
    Inventor: Thomas Happe
  • Patent number: 7166469
    Abstract: A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages are, first, the non-acute stage, which is either asymptomatic coronary artery disease or stable angina, second, the acute stage known as unstable angina, and, third, the acute stage known as acute myocardial infarction. The diseased state (as opposed to the non-diseased state) is indicated by the clinically significant presence of a first marker in a sample from the patient. The presence of one of the two acute stages, unstable angina or acute myocardial infarction, is indicated by the clinically significant presence of a second marker in a sample from the patient. The presence of the more severe acute stage known as acute myocardial infarction is indicated by the clinically significant presence of a third marker in a sample from the patient.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: January 23, 2007
    Assignee: Leuven Research & Development VZW
    Inventors: Paul N. Holvoet, Désiré J. Collen
  • Patent number: 7157259
    Abstract: This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein, a pharmaceutical composition comprising the protein, the partial peptide or its salt; and an antibody to the protein or the partial peptide. The protein, the partial peptide or its salt, and the DNA are useful as an agent for treating or preventing arteriosclerosis, atherosclerosis, hyperlipidemia, hypercalorism, obesity or hypertriglyceridemia. The antibody can be used in assay of the protein, the partial peptide or its salt. The protein, the partial peptide or its salt is useful as a reagent for the screening for candidate medical compounds.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: January 2, 2007
    Assignee: Takeda Pharmaceutical Company Limited
    Inventor: Yoshio Taniyama
  • Patent number: 7144705
    Abstract: Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish stroke from AMI requires an assay specific to AMI, e.g. using troponin-I or creatine kinase-MB as a marker, also to be carried out.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: December 5, 2006
    Assignee: ElectroPhoretics Limited
    Inventors: Denis Francois Hochstrasser, Jean-Charles Sanchez, Catherine Gabrielle Zimmerman
  • Patent number: 7052855
    Abstract: A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: May 30, 2006
    Assignee: Fujirebio, Inc.
    Inventors: Yoshiaki Uchida, Yoshihiro Kurano
  • Patent number: 7053176
    Abstract: Pharmaceutical composition for the treatment of infant respiratory distress syndrome and acute lung injury (including adult respiratory distress syndrome) which contains C1 esterase inhibitor (C1-INH) and lung surfactant which comprises a lung surfactant protein.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: May 30, 2006
    Assignee: Altana Pharma AG
    Inventors: Dietrich Häfner, Paul-Georg Germann, Nils Ott, Burkhard Vangerow, Horst Rückoldt, Gernot Marx, Michael Cobas Meyer, Martin Leuwer
  • Patent number: 6939713
    Abstract: The present invention relates to an assay for determining the levels of sterols, stanols, steryl esters, fatty acid derivatives and combinations thereof in a starch-containing food product. The assay is particularly useful in supporting product health and/or nutritional claims in manufacturing products intended for human or animal consumption. The present invention describes a method for extracting sterols related compounds and uses as an internal standard a steryl ester, preferably cholesterol oleate. By using the present extraction technique the process enables the recovery of substantially all of the sterol related compound in the sample.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: September 6, 2005
    Assignee: General Mills, Inc.
    Inventors: Daniel J. Lewandowski, David W. Plank
  • Patent number: 6893018
    Abstract: A game machine is provided with first, second and third reel rows, and each of the reel rows executes slot game independent from each other. The number of reel rows to be actuated is increased in proportion to the number of bet coins. When less than three coins are betted, a first privilege providing section is operated to judge whether the first winning is generated. The first and a second privilege providing sections are operated to judge whether the first winning and a second winning are generated when four coins are betted. Dividend coins are provided in the first winning and a free game in the second winning. A player may play slot game without betting a coin in the free game.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: May 17, 2005
    Assignee: Dragon Co., Ltd.
    Inventor: Haruo Inoue
  • Patent number: 6861260
    Abstract: The object of the present invention is to provide a lipid membrane whose permeability to substances is high and strongly correlated with the permeability of biomembranes to drugs and which therefore is suitable for rapid measurement. The present invention provides a membrane comprising an unsaturated C7-C9 hydrocarbon and a lipid.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: March 1, 2005
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventor: Kiyohiko Sugano
  • Patent number: 6780849
    Abstract: Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, wherein the lipid molecole is provided with a nitric-oxide contianing group which comprises a (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the ntric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods for treating or preventing various conditions, methods for promoting wound healing and methods for reducing the cells present in an atherosclerotic lesion which methods utilize the nitric-oxide releasing lipid molecules.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 24, 2004
    Assignee: SciMed Life Systems, Inc.
    Inventors: Robert A. Herrmann, Wendy Naimark
  • Patent number: 6767708
    Abstract: Aqueous solutions of steroid compounds which have biological activity and have a tendency to oxidative degradation at temperatures between 2 and 8° C. on storage in excess of several months are stabilized by the addition of chelators. Aqueous solutions of particular interest are protein containing solutions which mimic the behavior of human bodily fluids such as serum and are therefore suitable as standards for immunoassays for steroids in such bodily fluids. Chelators of particular interest are transition metal chelators especially those which efficiently sequester iron.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: July 27, 2004
    Assignee: Abbott Laboratories
    Inventors: Gregg T. Williams, Hoda I. Aboleneen, William R. Groskopf, Steven C. Kuemmerle
  • Publication number: 20030235918
    Abstract: The invention provides a data base of LDL, I, Ia, IIb, IIIa, IIb, IVa, IVb and HDL2a, HDL2b, HDL 3a, HDL 3b and HDL 3c together with patient data such as HDL-C, LDL-C, Apo A, ApoB, Lp(a) and patient personal data useful for treatment, diagnosing, and monitoring cardiovascular disease. The data base contains the LDL and HDL subfraction data in quantitative mg/dl values and permits deriving relationship amongst the LDL and HDL values and cardiovascular disease. Quantitative data permits more effective treatment and monitoring of cardiovascular disease. For example, quantitative differences in LDL and HDL subclass levels can determine the need for more or less aggressive treatment. The data base which includes patient events, procedures, interventions which is correlated to LDL and HD1 quantitative subclass data permits development of personalized patient treatment plans and monitoring the effectiveness of such treatment.
    Type: Application
    Filed: April 12, 2003
    Publication date: December 25, 2003
    Applicant: Berkeley HeartLab, Inc.
    Inventors: David Shewmake, Frank Ruderman, Christopher Boggess, Faith Clendenen
  • Patent number: 6653140
    Abstract: Methods for assessing a patient's risk of having or developing coronary heart disease based on lipoprotein measurements measure and identify values for lipoprotein subclass constituents and analyze according to predetermined test criteria to identify when there is an increased and/or decreased risk of having and/or developing coronary heart disease associated wit the measured lipoprotein subclass constituent values.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: November 25, 2003
    Assignee: Liposcience, Inc.
    Inventor: James D. Otvos