Composition For Standardization, Calibration, Simulation, Stabilization, Preparation Or Preservation; Processes Of Use In Preparation For Chemical Testing Patents (Class 436/8)
  • Patent number: 10278632
    Abstract: Certain embodiments of a sensor cartridge element include a sensor module, an electrode arrangement installed on the sensor module, and a delivery arrangement securely coupled to the sensor module. The sensor module includes an analysis cell and a skin piercing member. The electrode arrangement generates an electrical signal when exposed to a fluid sample collected in the analysis cell. The delivery arrangement includes a drug reservoir, a piston chamber, and a valve arrangement providing selective fluid communication between the drug reservoir and the piston chamber. Metering electronics and an actuator can manage collection of fluid samples and/or dispensing of drug doses.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: May 7, 2019
    Assignee: Pepex Biomedical, LLC.
    Inventor: James L. Say
  • Patent number: 10229091
    Abstract: A method reconstructing optical properties of a medium uses a reconstruction system having a radiation source illuminating a medium and a detector receiving a signal emitted by the medium. This method includes establishing, for a source-detector pair, a first distribution of a signal received by the detector for a reference medium, the received signal emitted by the reference medium subsequent to the illumination of the medium by the source, determining, for the source-detector pair, a first modeling function of a light scattering signal between the source and the detector in the reference medium, establishing, for the source-detector pair, a second distribution of a signal received by the detector for the medium, the received signal being emitted by the medium to be characterized subsequent to illumination of said medium by the source, and computing a signal corrected as a function of the first modeling function and of the second distribution.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: March 12, 2019
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventor: Lionel Herve
  • Patent number: 10131133
    Abstract: An optically heterogeneous phantom structure for use in optical imaging techniques. The phantom structure includes an external shape simulating an object to be subjected to an optical imaging technique, the external shape defining an external surface that encloses an internal volume of the external shape; and an optically heterogeneous material filling the internal volume and having heterogeneous optical properties for simulating at least one optical parameter of at least one region within the object. A method of producing the optically heterogeneous phantom structure. The method includes selectively depositing precursors of a first material and a second material by 3D printing so that the precursor of the second material is surrounded by the precursor of the first material within a predetermined internal region of the precursor of the first material, and forming the phantom structure. Variations of the method include additives to the materials.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: November 20, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Brian Zahler Bentz, Kevin J Webb
  • Patent number: 10073104
    Abstract: Aqueous calibration or quality control reagents that include urea are disclosed; the reagents may further include at least one amino acid-containing composition to provide pH stability thereto. Methods of production and use thereof are also disclosed.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 11, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Laura Uretsky, Kevin Horan
  • Patent number: 9927445
    Abstract: A method for the risk detection, early diagnosis, prognosis, and monitoring of Parkinson's disease in an individual by measuring the amount of specific biomarkers present in a bodily fluid and comparing them to a reference level of biomarkers in a sample from a healthy person, a person previously diagnosed with Parkinson's disease, or an earlier sample from the individual of interest.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: March 27, 2018
    Inventors: Balwant Rai, Jasdeep Kaur
  • Patent number: 9891193
    Abstract: The invention is directed to a swipe with at least one ionization reagent associated with the swipe for detecting target analytes and methods of detecting the target analyte molecules that can indicate the presence of, for example, explosives, narcotics, chemical warfare agents, biological warfare agents, or toxins. The swipe can be used to transfer molecules from a surface to the swipe for further analysis. In particular, the swipes can include an ionization reagent that is preferably a low volatility compound and capable of forming ionization reagent-analyte complexes with target analytes. The swipe can also include multiple ionization reagents with different volatilities such that they are released sequentially during a thermal ramp-up. Alternatively, the swipe can have multiple ionization reagents associated with spatially separated portions of the swipe such that they can be releasable sequentially to detect multiple target analytes.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 13, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Kerin E. Gregory, Roderick R. Kunz
  • Patent number: 9885643
    Abstract: A novel reagent for clarification of an emulsion containing a salt and first and second surfactants is used in a method of clarifying emulsions which may contain inorganic, organic or biological particles to be measured. The reagent may be proved as kit of parts for in situ preparation thereof.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: February 6, 2018
    Assignee: Bentley Instruments S.A.R.L.
    Inventors: Norbert Pautz, Pierre Broutin
  • Patent number: 9658352
    Abstract: A measurement standard suitable for measuring amounts of certain elements in pharmaceutical excipients is described. A reference standard is dissolved in a solvent, for example acetone, and mixed with a pharmaceutical excipient such as cellulose, lactose or calcium carbonate. The solvent is then evaporated to provide a dry standard.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: May 23, 2017
    Assignee: PANALYTICAL B.V.
    Inventors: Mark Ingham, Leian Grimsley
  • Patent number: 9546355
    Abstract: The present invention relates to methods of inducing an immune response to cytomegalovirus (CMV) using a genetically modified CMV that is conditionally replication defective. The methods of the invention can be used to treat and/or prevent primary CMV infection, infection due to reactivation of a latent CMV and a super-infection of a different strain of CMV that had been previously encountered. The present invention also relates to a replication defective CMV which has been recombinantly altered to allow for external control of viral replication. Compositions comprising the replication defective CMV are also encompassed by the present invention.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: January 17, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Tong-Ming Fu, Dai Wang, Muneeswara Babu Medi
  • Patent number: 9529002
    Abstract: A method for the risk detection, early diagnosis, prognosis, and monitoring of Alzheimer's disease in an individual by measuring the amount of specific biomarkers present in a bodily fluid and comparing them to a reference level of biomarkers in a sample from a healthy person, a person previously diagnosed with Alzheimer's disease, or an earlier sample from the individual of interest.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: December 27, 2016
    Inventors: Balwant Rai, Jasdeep Kaur
  • Patent number: 9504641
    Abstract: A method of treating a patient who has extravasation of blood from an intravascular compartment to an extravascular compartment. An agent is administered to the patient which mitigates a harmful effect of break-down products of blood at an extravascular site, resulting in the patient having reduced morbidity and mortality. The morbidity and mortality of the patient is further reduced by concomitant administration of a suspension of submicron protein spheres having a molecular weight of ranging from 780 billion Daltons to less than 0.8 billion Daltons.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: November 29, 2016
    Inventor: Richard C. K. Yen
  • Patent number: 9499870
    Abstract: Embodiments of the invention include methods and compositions for producing proficiency testing standards for noninvasive prenatal genetic diagnostics and for the detection and monitoring of cancer. The compositions can include a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant woman or naturally occurring cell free DNA samples obtained from the blood of cancer patients.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: November 22, 2016
    Assignee: Natera, Inc.
    Inventors: Joshua Babiarz, Bernhard Zimmermann
  • Patent number: 9410144
    Abstract: The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field. The new methods provide for isolation of WBC preparations with high yield, purity, and viability. The methods are designed for compatibility with automation protocols for rapid processing of multiple samples.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: August 9, 2016
    Assignee: The General Hospital Corporation
    Inventors: Denise L. Faustman, Douglas E. Burger
  • Patent number: 9377467
    Abstract: The present invention relates to reagents for separating proteins from detergent, reagents for detecting proteins in the presence of a detergent, and methods of using the same. The separating reagents contain a cyclic oligomer such as cyclodextrin and a cellulose derivative such as 2-hydroxyethyl cellulose. When used in combination with standard protein-complexing dyes, the reagents allow detection of proteins in electrophoresis gels at nanogram levels.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: June 28, 2016
    Assignee: ACQUASCIENCE LIMITED
    Inventors: Andre T. R. M. A. Neves, Brian Page
  • Patent number: 9377429
    Abstract: This invention relates to a correction liquid for a liquid membrane type ion-selective electrode that makes it possible to measure a ratio between a sodium ion concentration and a potassium ion concentration in urine by correcting for an influence from an ionic strength of the urine. The correction liquid comprises a sodium ion-sensitive part that selectively reacts with the sodium ion and a potassium ion-sensitive part that selectively reacts with the potassium ion, and measures a ratio between a sodium ion concentration and a potassium ion concentration in urine, and comprises the sodium ion, the potassium ion, and an electrolytic ionic strength modifier.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: June 28, 2016
    Assignee: HORIBA, Ltd.
    Inventor: Yasukazu Iwamoto
  • Patent number: 9297821
    Abstract: A method and system for testing the functional capability of an analytical instrument uses first and second blind samples. Each blind sample is a test substance with an amount of a parameter to be tested that is unknown to the user. Each blind sample is provided with an identification means with a unique identification. When the blind samples are tested by the user in the instrument being tested, the measurement values obtained and the unique identifications read are compared against predetermined values that are accessible to a test program configured as software on the analytical instrument. By comparison of the measurement values and the predetermined values, the functional capability of the analytical instrument is determined and the result is transmitted to an output unit of the analytical instrument.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 29, 2016
    Assignee: Mettler-Toledo GmbH
    Inventors: Christian Walter, Félix Bécheiraz, Manuela Gerber, Rolf Rohner
  • Patent number: 9290810
    Abstract: In one embodiment, a product includes a plurality of particles, each particle including: a carrier that includes a non-toxic material; and at least one DNA barcode coupled to the carrier, where the particles each have a diameter in a range from about 1 nanometer to about 100 microns.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: March 22, 2016
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: George R. Farquar, Roald N. Leif, Elizabeth Wheeler
  • Patent number: 9279750
    Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Crystal Violet, New Methylene Blue, Saponin, and Gluteraldehyde.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 8, 2016
    Assignee: Iris International, Inc.
    Inventors: Jack Cremins, Carol Quon
  • Patent number: 9244036
    Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that an estimated interferent value can be determined so that such interferent value can be used to correct the current transients at specific time points for more accurate glucose concentration determination.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: January 26, 2016
    Assignee: Cilag GmbH International
    Inventor: Aurelie Colas
  • Patent number: 9170198
    Abstract: Techniques are disclosed relating to analysis and reduction of crosstalk between signals. These techniques may be applicable in many fields, such as single-tube PCR or DNA melt analysis, PCR or melt data from neighboring wells of a multi-well plate, capillary electrophoresis data (e.g., DNA sequencing), gas chromatography, multispectral imaging, dual-color fluorescence correlation spectrometry, electrical crosstalk, etc. According to one embodiment, crosstalk between fluorescence signals from different species may be determined based on a correlation between the time derivatives of the fluorescence signals from the fluorescent species.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: October 27, 2015
    Assignee: Luminex Corporation
    Inventor: Arnold Estrada
  • Patent number: 9091582
    Abstract: A system and related method for determining the volume of a sample solution delivered by a liquid delivery device. The system includes devices for adding and removing diluent, the sample solution under analysis and a mixture of the two in a cell having a substantially constant cross sectional area and a known horizontal optical path length. The system includes one or more spectrophotometers to measure horizontally and vertically absorbance associated with two distinct chromophores. A first chromophore of unknown concentration is in the diluent and a second chromophore of known concentration is in the sample solution. The method determines absorbance horizontally and vertically of the first chromophore prior to adding the sample solution and then determining absorbance of the first chromophore horizontally and vertically and the second chromophore horizontally after mixing the diluent and sample solution together. That information is used to determine the volume of the sample solution added to the cell.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: July 28, 2015
    Assignee: Artel, Inc.
    Inventor: Richard H. Curtis
  • Patent number: 9091764
    Abstract: A liquid mixture used to test and validate test devices for inspecting objects or persons is provided. The mixture containing glycerol and consisting of a mixture of glycerol, ethanoic acid and water.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: July 28, 2015
    Assignee: Smiths Heimann GmbH
    Inventor: Uwe Siedenburg
  • Publication number: 20150147815
    Abstract: Embodiments of the invention include methods and compositions for producing proficiency testing standards for noninvasive prenatal genetic diagnostics and for the detection and monitoring of cancer. The compositions can comprise a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant woman or naturally occurring cell free DNA samples obtained from the blood of cancer patients.
    Type: Application
    Filed: September 26, 2014
    Publication date: May 28, 2015
    Inventors: Joshua Babiarz, Bernhard Zimmermann
  • Publication number: 20150140593
    Abstract: A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (LC-MS) methods, more especially for LC-MS methods employing electrospray (ESI) or atmospheric pressure chemical ionization (APCI) ionization systems.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Inventor: Michael Arthur Quilliam
  • Patent number: 9034652
    Abstract: Colloidal formulation for staining proteins and methods of their use are provided.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: May 19, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Christopher Belisle, Lee Olech, Thomas Berkelman, Praveena Garimella
  • Publication number: 20150132854
    Abstract: Provided are synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures. The latter characteristic enables parallel preparation of higher molecular weight compounds displaying useful distributions of discrete molecular weights, thereby providing multi-point mass spectrometry calibration standards. Methods of making, tuning and using said calibrants are provided.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 14, 2015
    Inventor: Scott Grayson
  • Patent number: 9029154
    Abstract: A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region. The apparatus includes a substrate locator for locating the substrate; a cover locator for locating and moving the cover with respect to the substrate; a fluid dispenser for dispensing fluid into the reaction chamber; and a draining mechanism which includes a wick.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: May 12, 2015
    Assignee: Leica Biosystems Melbourne Pty Ltd
    Inventors: Stuart Elliot, Andrew McLellan, Chester Henderson, Mark Dockrill, Simon Harris, Peter Riddell
  • Patent number: 9023650
    Abstract: A simulant that includes a carrier and DNA encapsulated in the carrier. Also a method of making a simulant including the steps of providing a carrier and encapsulating DNA in the carrier to produce the simulant.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 5, 2015
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: George Roy Farquar, Roald N. Leif, Elizabeth Wheeler
  • Patent number: 9012137
    Abstract: The present invention refers to a method of processing a biological fluid which comprises cellular components by a freezing/thawing treatment. The method is particularly useful for preparing biological samples for analyte detection.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: April 21, 2015
    Assignee: Thermo Finnigan LLC
    Inventor: Dietrich Seidel
  • Publication number: 20150104876
    Abstract: The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunological reagents.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 16, 2015
    Inventors: Apostolos Kyriatsoulis, Susanne Feldmann, Eramus Huber, Nicole Horn, Leopold von Proff, Uwe Kobold, Angela Puhlmann
  • Publication number: 20150087544
    Abstract: A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel.
    Type: Application
    Filed: September 6, 2014
    Publication date: March 26, 2015
    Inventors: Martin A. Putnam, Jeffrey T. Branciforte, Charles O. Stanwood
  • Patent number: 8986998
    Abstract: Disclosed herein is a method for identifying the compounds contributing to a pungent odor from an air conditioner, a method for artificially reproducing the pungent odor, and preparing a corresponding pungent odor composition. Through the analysis method of the present invention, the compounds contributing to the pungent odor from an air conditioner may be identified and quantified. The pungent odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced pungent odor may provide significant data required for development of an apparatus and a method for removing specific odors.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 24, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Patent number: 8975080
    Abstract: A biosensor calibration method configured to measure a concentration of a specific substance contained in sample liquid to be measured, including: a first step configured to acquire a first output value that is output by the biosensor when first calibration liquid is brought into contact with the biosensor; a second step configured to acquire a second output value that is output by the biosensor when second calibration liquid having a different concentration from that of the first calibration liquid is continuously brought into contact with the biosensor after the first step and determine time for replacement of the biosensor on the basis of the first output value and the second output value.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 10, 2015
    Assignee: Tanita Corporation
    Inventors: Satoshi Ikeda, Mariko Kose, Tatsuro Murayama, Yuri Kinoshita
  • Patent number: 8973422
    Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: March 10, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Huan-Ping Wu, Christine D. Nelson
  • Patent number: 8969083
    Abstract: A method that identifies the compounds contributing to a fish-like odor from an air conditioner and artificially reproduces the fish-like odor, and prepares a corresponding fish-like odor composition. Through the analysis method of the present invention, the compounds contributing to the fish-like odor from an air conditioner are identified and quantified. The fish-like odor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced fish-like odor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: March 3, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Sang Jun Lee, Seok Man Kim
  • Patent number: 8969084
    Abstract: A method that identifies the compounds contributing to a sweet odor from an air conditioner, reproduces the sweet odor, and prepares a corresponding sweet odor composition. Through the analysis method of the present invention, the compounds contributing to the sweet odor from an air conditioner are identified and quantified. The sweet odor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sweet odor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: March 3, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Seok Man Kim, Sang Jun Lee
  • Patent number: 8962334
    Abstract: A method is provided that identifies the compounds contributing to a malodor from an air conditioner, reproduces the malodor, and prepares a corresponding malodor composition. Through the analysis method of the present invention, the compounds contributing to the malodor from an air conditioner are identified and quantified. The malodor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced malodor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: February 24, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Chi Won Jeong, Ji Wan Kim, Sun Dong Kim, Sang Jun Lee, Seok Man Kim
  • Patent number: 8951746
    Abstract: The present invention provides multi-parameter analysis methods for determining the presence or absence of pre-cancerous or cancerous cells in a cervical sample and for screening cervical abnormality in a cervical sample. The invention also provides an apparatus and automated methods for screening cervical abnormality in a sample. The invention further provides a sampling device and a sample collection assembly for collecting cell samples, including cervical samples.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: February 10, 2015
    Assignee: Southwest Research Institute
    Inventors: Urs G. Wiederkehr, Jian Ling
  • Publication number: 20150031135
    Abstract: A method for calibrating an imager of a reagent analyzer, comprises positioning a dry reagent pad at a first read position in a field of view of the imager, the first read position illuminated by an illumination source with a first intensity, detecting a reference optical signal by the imager, indicative of a first reflectance value of the dry reagent pad at the first read position, positioning the dry reagent pad at a second read position, the second read position illuminated with a second intensity different from the first intensity, detecting a first optical signal by the imager, indicative of a second reflectance value of the dry reagent pad at the second read position, and calculating, by a processor, a calibration factor for the dry reagent pad at the second read position based on a difference between the reference optical signal and the first optical signal.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 29, 2015
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventors: Chris Thomas Zimmerle, Amy Zercher, Jennifer Ann Goldsburg
  • Patent number: 8932580
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: January 13, 2015
    Assignees: Hyglos Invest GmbH, Biomerieux S.A.
    Inventors: Michael Schutz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Patent number: 8921113
    Abstract: A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 30, 2014
    Assignee: Dionex Corporation
    Inventors: Shanhua Lin, Christopher A. Pohl
  • Patent number: 8900877
    Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: December 2, 2014
    Assignee: Luminex Corporation
    Inventors: Steve Jia Chang Yu, Jesus Ching, Phillip You Fai Lee, David Hsiang Hu
  • Publication number: 20140329327
    Abstract: A synthetic urine solution and method of its manufacture are disclosed. The solution includes water having a pH between about 3 and about 10. The solution further includes creatinine, a means for removing bacteria from the solution so as to control or eliminate sepsis of the urine solution, preferably through the use of a biocide, and a urea-based compound. The solution exhibits a specific gravity of from 1.005 g/cm3 to 1.025 g/cm3. Additional compounds may also be included to further enhance the aesthetics or apparent authenticity of the synthetic urine.
    Type: Application
    Filed: May 6, 2014
    Publication date: November 6, 2014
    Inventor: James Matthew Stephens
  • Patent number: 8871517
    Abstract: A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: October 28, 2014
    Assignee: Bayer Healthcare LLC
    Inventors: Jing Lin, Fu Hsiung Tsai, Huan-Ping Wu, Nicole D. Ellis, Henry C. Arndt
  • Patent number: 8865470
    Abstract: The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: October 21, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Ming Yan, Alan M. Stall, Joseph T. Trotter, Robert A. Hoffman
  • Patent number: 8852946
    Abstract: Disclosed herein is a method for identifying the compounds contributing to urine odor emitting from an air conditioner, a method for artificially reproducing the detected urine odor, and preparing a corresponding urine odor composition. Through the analysis method of the present invention, the compounds contributing to the urine odor emitted from an air conditioner may be identified and quantified. The detected urine odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced urine odor may provide meaningful data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 7, 2014
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Seok Man Kim
  • Patent number: 8852945
    Abstract: Disclosed herein is a method for identifying compounds contributing to a sour odor emitting from an air conditioner, a method for artificially reproducing the detected sour odor and preparing a corresponding sour odor composition. Through the analysis method of the present invention, the compounds contributing to the sour odor emitted from an air conditioner may be identified and quantified. The detected sour odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sour odor may provide meaningful data required for development of an apparatus and a method for removing specific odors.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 7, 2014
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Patent number: 8841133
    Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: September 23, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Huan-Ping Wu, Christine D. Nelson
  • Patent number: 8835178
    Abstract: A bio-threat simulant that includes a carrier and DNA encapsulated in the carrier. Also a method of making a simulant including the steps of providing a carrier and encapsulating DNA in the carrier to produce the bio-threat simulant.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: September 16, 2014
    Assignee: Lawrence Livermore National Security, LLC.
    Inventors: George Roy Farquar, Roald Leif
  • Patent number: 8835125
    Abstract: Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within multilabel assays which employ the biotin-biotin binding protein binding relationship for each distinct label in relation to targets such as nucleic acids, polypeptides, antibodies or cells. These multilabel assays are enabled through the use of biotin with desthiobiotin, orthogonal protecting schemes for biotin, or a combination of the approaches.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 16, 2014
    Assignee: Affymetrix, Inc.
    Inventors: Robert G. Kuimelis, Glenn H. McGall, Stephen P. A. Fodor