Abstract: Methods are provided that operate on raw dissociation data and dissociation curves to generate calibrations of the detected data and to further improve analysis of the data. The data can be taken from each support region of a multi-region platform, for example, from each well of a multi-well plate. Each support region can be loaded with portions of the same sample. In some embodiments, a dissociation curve correction can be calibrated for the sample, prior to a run of an experiment using such sample. In some embodiments, a method is provided for generating a melting transition region of dissociation curves that show the melting characteristics of the sample. In some embodiments, dye temperature dependence correction can be performed on the dissociation curve data to further improve analysis. In some embodiments, a feature vector can be derived from the melt data, and the feature vector can be used to further improve genotyping analysis of the dissociation curves.

Abstract: Disclosed is a method for determining when to replace a guard bed material used to remove one or more catalyst poisons from a feed based on a parameter change in a process. A guard bed having a guard bed material is in fluid communication with a catalyst bed having a catalyst. At least three monitors are positioned in said guard bed or said catalyst bed and at least one parameter of the guard bed or catalyst bed is monitored. A feed component comprising one or more catalyst poisons is supplied to said guard bed or said catalyst bed. The feed is contacted with said guard bed material or said catalyst to remove at least a portion of a catalyst poison and to form a product which produces an increase or a decrease in said parameter. The monitored parameters are compared to determine when to replace the guard bed material.

Abstract: A differential scanning calorimeter (1) includes: a sample container (2) for receiving a measurement sample; a reference substance container (3) for receiving a reference substance; a heat sink (10); a thermal resistance (5), which is connected between the sample container and the heat sink, and between the reference substance container and the heat sink to form heat flow paths therebetween; a sample-side thermocouple (7), which is thermally connected to the thermal resistance at a portion in the vicinity of the sample container with its hot-junction (7c) being insulated; and a reference substance-side thermocouple (8), which is thermally connected to the thermal resistance at a portion in the vicinity of the reference substance container with its hot junction (8c) being insulated, in which the sample-side thermocouple and the reference substance-side thermocouple output a heat flow difference signal indicating a temperature difference between the measurement sample and the reference substance.

Abstract: A device to measure the residual power of a charge, comprising: means delimiting a first vessel to receive and contain a charge to be measured; means delimiting a second vessel around the first vessel; means to apply a layer of liquid or wet layer around the first vessel; and means to maintain constant the temperature and/or pressure of a vapor outside the first vessel or in the second vessel.

Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.

Abstract: A device and method which comprises a sensing surface on a membrane, solid surface or electrode, where the sensing surface contains a dye or chromophore chosen in relation to a particular target substance to be detected and quantified. The dye or chromophore is of a type which produces an electrical signal upon illumination. The particular dye or chromophore chosen for a particular target substance is one in which the presence of the target substance causes a change in the electrical signal produced. The presence of the target substance modifies the expected photo-induced charge movements (PICM) produced by the sensing surface upon illumination. The photo-induced charge movements produce signals which are detected by electronic circuits, and the presence and concentration of the target substance is determined by analyzing the difference between the PICM of the target sample versus the PICM of a control sample lacking the target substance.

Abstract: A nanocalorimeter includes a merging layer having, a drop placement area for holding drops to be merged and a thermal equilibration area. A measurement layer includes a substrate, and a temperature probe on the substrate, wherein the temperature probe extends out of the surface of the substrate to come into operative contact with the thermal equilibration area when the measurement layer is placed in operative association with the merging layer. The nanocalorimeter is configured to have the merging layer and the measurement layer non-integrated, making the measurement layer reusable.

Abstract: The invention relates to a device for the carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel receiving element. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.

Abstract: A thermal analysis device comprising a replaceable sensor that can be contacted via a contact element of an electrical contacting means, a heating element and a cooling element. The contact element(s) is thermally connected with the heating element and can be heated essentially independently of the operating state of the cooling element even when no sensor is mounted to the device.

Abstract: Provided is a biochemical analyzer including: a microfluidic device loading space including a microfluidic device supporting unit detachably supporting a microfluidic device including an electromagnetic radiation application region in which electromagnetic energy is applied; an energy source loading space including an energy source applying the electromagnetic energy to the electromagnetic radiation application region; and an isolation wall isolating the microfluidic device loading space and the energy source loading space to prevent heat transfer between the microfluidic device loading space and the energy source loading space and including a transparent window through which the electromagnetic energy can be transmitted. A method of controlling an internal temperature of the biochemical analyzer is also provided.

Abstract: A calorimeter (1) with a decomposition chamber (3) with a combustion chamber (2), in which a receiving device (4) for a sample, an ignition device (5), and at least one supply line (6) for oxygen are provided. The decomposition chamber (3) is surrounded by a liquid or water jacket (7) into which at least one temperature sensor (8) extends. The liquid or water jacket (7) is surrounded by an outer container (9), which is a pressure container and which absorbs pressure generated during the combustion of a sample in the decomposition chamber (3) at the walls (10) thereof as a result of a tight sliding fit (15) by way of the water or the incompressible liquid. The decomposition chamber (3) therefore has an accordingly thin wall so that the heat generated during combustion of a sample can reach the temperature sensor or sensors (8) quickly.

Abstract: A device and method which comprises a sensing surface on a membrane, solid surface or electrode, where the sensing surface contains a photo-voltage active material chosen in relation to a particular target substance to be detected and quantified. The photo-voltage active material is of a type which produces an interfacial photo-voltage electrical signal upon illumination. The particular photo-voltage active material chosen for a particular target substance is one in which the presence of the target substance causes a change in the electrical signal produced. The presence of the target substance modifies the expected photo-voltage produced by the sensing surface upon illumination. The photo-voltage produces signals which are detected by electronic circuits, and the presence and concentration of the target substance is determined by analyzing the difference between the photo-voltage of the target sample versus the photo-voltage of a control sample lacking the target substance.

Abstract: Alkalinity determination, including an alkalinity determination process and/or alkalinity determinator. An alkalinity determination process may include providing a known value of volume of an acidic fluid, forming a titration system by providing one or more additions of a known value of volume of a relatively alkaline fluid to an acidic fluid, determining a pH value and/or a temperature value for one or more additions and/or determining an alkalinity value of a system by calculating a transformation including one or more determined pH values and/or temperature values of one or more additions. An alkalinity determination process may include modeling, such that an informed determination may be made with reference to relevant and/or irrelevant factors, as well as parameters to maximize likelihood of alkalinity determination. In embodiments, an alkalinity determinator may include one or more titration cells, one or more sensors and/or one or more alkalinity value determinators.

Abstract: An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.

Abstract: Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.

Abstract: A system and method for characterizing a liquid hydrocarbon fuel having unknown or variable composition is described and shown herein.

Abstract: The subject matter described herein relates to thermoresponsive switching materials that undergo a thermal transition over a narrow temperature range and to devices, such as actuators, indicators, and sensors, prepared from such compositions.

Abstract: A beverage dispensing device including a housing, a tapping device for dispensing a beverage, a beverage container connectable with the tapping device, a freshness indicator device, a data input unit for recording replacement of the beverage container, a temperature sensor for measuring the storage temperature of the beverage, a temperature controller for adjusting the cooling temperature of a chiller, a storage unit for storing the freshness criteria, and a processing unit. The temperature sensor transmits the current beverage storage temperature to the processing unit and the processing unit calculates, depending on a recorded storage temperature period and based on stored freshness criteria, the actual freshness of the beverage, the time left until expiry of the freshness of the beverage and/or the date of expiry of the freshness of the beverage. The processing unit transmits the calculated data to the display.

Abstract: A particle sensor is provided having a first temperature sensing device having a sensing surface exposed to particles contained within a fluid. The sensing surface is at least partially coated with a catalyst for promoting an exothermic reaction with at least a portion of the particles. The particle sensor also has a second temperature sensing device positioned at a location substantially thermally isolated from thermal energy generated by the exothermic reaction.

Abstract: New sensors and methods for qualitative and quantitative analysis of multiple gaseous substances simultaneously with both high selectivity and high sensitivity are provided. The new sensors rely on a characteristic difference in energy between the interaction of a particular substance with a catalyst coated heat transfer device (HTD) and a non-catalyst coated (or one coated with a different catalyst) reference HTD. Molecular detection is achieved by an exothermic or endothermic chemical or physical reaction between the catalytic surface of the sensor and the molecule, tending to induce a temperature change of the sensor. Both high temperature and non-destructive low temperature detection are possible. The magnitude and rate of endothermic or exothermic heat transfer from a specific molecule-catalyst interaction is related to molecular concentration.

Abstract: A concentration monitor for monitoring a concentration of a plurality of use solutions, each of the plurality of use solutions being, at least, a concentrate in a diluent, each of the plurality of use solutions having a resistivity which varies as a function of both temperature and an amount of the concentrate contained in a given amount of the diluent. A resistivity probe is adapted for use with at least one of the plurality of use solutions for taking a measurement related to the resistivity of the at least one of the plurality of use solutions. A temperature sensor is adapted for use with the at least one of the plurality of use solutions for taking a measurement related to the temperature of the at least one of the plurality of use solutions.

Abstract: Methods for determining the fouling propensity of a hydrocarbon stream and for reducing fouling are provided. In one method, the fouling propensity of a hydrocarbon stream is determined by obtaining a parameter value indicative of the fouling propensity at no less than two different temperatures, and an activation energy of fouling by the hydrocarbon stream is derived therefrom. In another method, the thus obtained parameter value at no less than two different temperatures and the activation energy are used to select proper heating fluids and operating temperature and to determine whether to add an antifoulant to the hydrocarbon stream to reduce fouling at a given temperature.

Abstract: A sample processing apparatus prevents samples and reagents from being degraded due to a prolonged waiting time other than for reaction and improves the operation efficiency of the apparatus. The apparatus includes a plurality of processing sections for causing at least two samples to react independently, an input/output terminal 15 for inputting the upper limit of the waiting time and the reaction time for each of the samples, a schedule management section for determining at least the clock time of introducing each of the samples, the processing section to be used for processing the sample and/or the waiting time for the sample, and a general control section for controlling the processing of the samples at the plurality of processing sections according to the determination by the schedule management section.

Abstract: The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.

Abstract: An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.

Abstract: A system for detecting defects in a combustion duct of a combustion system of a combustion turbine engine while the combustion turbine engine operates, wherein the combustion duct comprises a hot side, which is exposed to combustion gases and, opposing the hot side, a cold side. In one embodiment, the system comprises: a photodetector aimed at the cold side of the combustion duct, the photodetector being configured to detect a visible change to the cold side of the combustion duct.

Abstract: A measured system for use with a calorimeter and related methods of operation.

Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.

Abstract: Freeze indicators can include an indicator dispersion, a liquid medium, indicator particles dispersed in the liquid medium and a particulate inorganic nucleating agent to inhibit supercooling of the liquid medium. The inorganic nucleating agent can have an ionic surface coating which can help provide a sharp end point. Optionally, freeze indicators can include indicator particles comprising an organic material and a softener to soften the indicator particles and provide the freeze indication with an enhanced visual appearance. Another option is to provide a temperature-sensitive stabilizer to inhibit coagulation of the indicator dispersion at temperatures above the liquid medium frozen state melting point while permitting coagulation of the indicator dispersion at the liquid medium frozen state melting point.

Abstract: A chemical sensor for assessing a chemical of interest. In typical embodiments the chemical sensor includes a first thermocouple and second thermocouple. A reactive component is typically disposed proximal to the second thermal couple, and is selected to react with the chemical of interest and generate a temperature variation that may be detected by a comparison of a temperature sensed by the second thermocouple compared with a concurrent temperature detected by the first thermocouple. Further disclosed is a method for assessing a chemical of interest and a method for identifying a reaction temperature for a chemical of interest in a system.

Abstract: This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source, at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte.

Abstract: An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.

Abstract: A particle sensor is provided having a first temperature sensing device having a sensing surface exposed to particles contained within a fluid. The sensing surface is at least partially coated with a catalyst for promoting an exothermic reaction with at least a portion of the particles. The particle sensor also has a second temperature sensing device positioned at a location substantially thermally isolated from thermal energy generated by the exothermic reaction.

Abstract: The present application relates to a chemical sensing device for detecting an analyte in a liquid sample containing suspended particles. The device comprises a radiation source adapted to generate electromagnetic radiation, a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, at least one reagent (2) on or proximal to the transducer (3), the reagent being capable of absorbing the electromagnetic radiation to generate energy when in contact with the analyte, a chamber (9) for holding the sample in fluid contact with transducer, and a detector which is capable of detecting the electrical signal generated by the transducer. The transducer is in a plane from +45° to ?45° to the vertical.

Abstract: A particle sensor is provided having a first temperature sensing device having a sensing surface exposed to particles contained within a fluid. The sensing surface is at least partially coated with a catalyst for promoting an exothermic reaction with at least a portion of the particles. The particle sensor also has a second temperature sensing device positioned at a location substantially thermally isolated from thermal energy generated by the exothermic reaction.

Abstract: Methods and apparatus for ultra-sensitive temperature sensing and calorimetry. Radiation is directed at a thin electrically conductive film having one or more small apertures. The incident radiation excites surface plasmons on a first surface of the electrically conductive film, and energy associated with the surface plasmons couples to an opposite surface of the electrically conductive film, where surface plasmon-enhanced radiation (SPER) is emitted from the aperture(s). A temperature-sensitive fluid or solid dielectric material is disposed contiguous with at least a portion of the electrically conductive film, such that a temperature change in the dielectric material alters a resonance condition for the SPER. Measurable changes in the SPER due to altered resonance conditions provide for an ultrasensitive temperature sensor that can detect small temperature changes in the dielectric material.

Abstract: An apparatus for characterizing parameters for the cracking, in-situ combustion, and upgrading of hydrocarbons includes a reactor defining a chamber, a temperature probe operably associated with the reactor, and a gas inlet in fluid communication with the chamber. The apparatus further comprises a gas outlet in fluid communication with the chamber and an electromagnetic radiation attenuating material configured to heat the reactor when the electromagnetic radiation attenuating material is irradiated by electromagnetic radiation.

Abstract: This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source; at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation of heat, which change in heat generation is proportional to the concentration of the analyte, a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing the change in heat to an electrical signal, and a detector which is capable of converting the electrical signal into an indication of the concentration of the analyte. The invention also relates to a method for detecting an analyte.

Abstract: A polymerization process is disclosed, including: polymerizing at least one olefin to form an olefin based polymer in a polymerization reactor; and feeding at least one ethyleneimine additive to the polymerization reactor. The ethyleneimine additive may comprise a polyethyleneimine, an ethyleneimine copolymer, or a mixture thereof. The process may further comprise monitoring static in the polymerization reactor; maintaining the static at a desired level by use of at least one ethyleneimine additive, the at least one ethyleneimine additive present in said reactor in the range from about 0.1 to about 50 ppm, based on the weight of polymer produced by said combining.

Abstract: A device for measuring/determining a physical quantity of a medium. The device comprises a sensor part and an electronic part, whereby at least the electronic part is arranged inside a housing and at least one fuel cell is provided which at least partially covers the energy demand of the device.

Abstract: The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).

Abstract: A biological agent detector detects the presence of any biological agents, such as anthrax or other biological warfare agents, in a sample of air. The biological agent detector includes a bio-concentrator that concentrates an aerosol and a pyrolyzer portion including two detecting devices. One detecting device operates in a sample collection mode and collects a sample of air when the other detecting device operates in a sample analysis mode and analyzes a sample of air. After a predetermined amount of time, the detecting devices switch functions, providing continuous sampling of air.

Abstract: A system to detect the presence of a catalyst includes an exhaust gas tube, a first temperature sensing device, a second temperature sensing device, a flow rate measurement device, and a processing device. The first temperature sensing device measures a first temperature of exhaust gas upstream of the exhaust gas tube. The second temperature sensing device measures a second temperature of the exhaust gas downstream of the exhaust gas tube. The processing device estimates an expected time delay between the measured inlet and outlet exhaust gas temperatures corresponding to a system with a catalyst present. The processing device may also determine the presence of a catalyst by comparing the measured second temperature to the measured first temperature and comparing the measured second temperature to an estimated delayed first temperature associated with the expected time delay.

Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.

Abstract: A passive differential calorimeter, comprising an inflow control valve (2?), differential measurement means (4?) including the driving part of an input water meter (15) and the driving part of an output water meter (16), a back flow control valve (9?) and connecting pipes between them, wherein both the inflow control valve and the output flow control valve being temperature controlled valve, i.e.

Abstract: A system and method that uses electrical conductivity measurements to identify the impurities in a solution, as well as the concentrations of such impurities. The conductance versus temperature curve for any particular ion is unique to that ion and the conductance versus temperature curve for a solution is unique to the ions in the solution and their concentrations. Equations can be used to describe the conductivity versus temperature curve containing specific ions at set concentrations. To that end, the present invention measures the conductivity of a solution over some specified temperature range, calculates a conductivity-temperature curve from a library of ions to match the measured conductivity, and uses a mathematical process to vary the ions and their concentrations in the calculated curve to make it match the measured curve as closely as possible.

Abstract: A system for detecting a wide range of microbial organisms, including virus, and determining concentrations in near real-time to determine titer, without the requirement to grow micro-organisms includes an electrometer configured to measure photo-induced interfacial voltages and an electrode assembly with a substrate and at least one electrode on a surface of the substrate electrically coupled to the electrometer. An attachment factor is applied to an exposed surface of each electrode. The attachment factor is effective for interaction with the microbial organism. A transparent vessel for containing the electrolytic solution is provided. The microbial organism may be contained in the electrolytic solution or applied to the coated electrode before being submerged in the electrolytic solution.

Abstract: In order to determine the gas hydrate anti-agglomeration power of a system composed of an aqueous phase dispersed in a liquid hydrocarbon phase in the presence of a gas, at least two successive cycles of hydrate formation and dissociation is carried out by cooling and reheating a sample of said system placed in the cell of a calorimeter to record thermograms; the anti-agglomeration power of said system is determined by comparing the thermograms obtained during the various cycles.

Abstract: A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer.

Abstract: Free-standing microfluidic channels are used to both transport and analyze molecules of interest. In a biochemical context, such molecules may be polypeptides, nucleic acids, or other biomolecules. The free-standing channels provide a real-time readout of concentration without the need for labeling with reporter molecules. The channels can also measure enthalpy values and equilibrium constants by detecting heat released from or absorbed by the sample.