Abstract: Various embodiments include methods and systems for reducing false-particle counts in a water-based condensation particle counter (CPC). One embodiment of a method includes delivering water into multiple wicks used for transporting separate portions of an aerosol sample flow, with the wicks extending from a wick stand on a first end to a flow joiner on a second end, combining particles from the separate portions of the aerosol sample flow into a single aerosol stream within the flow joiner prior to transporting the combined aerosol sample stream into a particle detection chamber within the CPC, sensing an excess volume of water delivered to the wicks, collecting the excess volume of water in a collection reservoir, and after receiving a signal corresponding to the excess volume of water, draining the excess volume of water from the collection reservoir. Other methods, systems, and apparatuses are disclosed.

Abstract: In order to increase the accuracy of dispensing liquid from a sealed liquid holding container without increasing device complexity, pressures inside and outside the sealed liquid holding container are measured with a pressure sensor connected to a dispensing probe, and the amount of discharge operation of a pump is corrected in accordance with the measured pressures. The amount of operation of the pump is corrected by calculating the amount of deformation of a dispensing flow passageway due to pressure change.

Abstract: A method adapted to allow aspiration verification of a liquid such as a biological liquid or liquid reagent at low aspiration volumes (e.g., less than 25 ?L). The method includes attempting to aspirate a volume of a liquid into a probe at an aspiration frequency, measuring an aspiration pressure associated with the attempted aspiration of the liquid and providing a measured pressure signal, and filtering the measured pressure signal with a filter. The filter has a passband frequency containing the aspiration frequency and excluding the frequencies of a disturbance causing noise in the measured pressure signal. Apparatus for carrying out the method are provided, as are other aspects.

Abstract: A wheeled vehicle includes a solid vehicle frame and a solid front axle including wheels movable to change the direction of the vehicle, a steering assembly including a steering wheel, a steering shaft coupled with the steering wheel, and a rotary output member having an end selectively movable in response to an input to the steering wheel, the solid front axle vehicle includes an electric power assist steering (EPAS) system for selectively steering the vehicle separately from any input to the steering wheel. The EPAS system includes a motor having a rotary output coupled to a steering gear and a steering rack having a longitudinal extent defining an axis having an end coupled a tie rod of the steering assembly. The longitudinal axis of the EPAS assembly is aligned with or transverse to the forward vehicle direction so its output is coupled to the output of the steering wheel and can be actuated independently.

Abstract: A multiple-substance-responsive substance is disclosed, which is capable of simultaneously detecting a plurality of detection target substances by a single measurement. By a multiple-substance-responsive gel including: a plurality of kinds of complexes including (i) specifically binding substances, and (ii) binding partners each specifically and reversibly binding to a corresponding one of the specifically binding substances; and a polymer gel to which the plurality of kinds of complexes are immobilized so as to form cross-links, the plurality of kinds of complexes each being formed by binding between (i) a specifically binding substance among the specifically binding substances and (ii) a corresponding binding partner among the binding partners, a plurality of detection target substances can be simultaneously detected by a single measurement.

Abstract: The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded piezoresistive microcantilever (EPM) sensor. Analytes that can be detected include noxious substances, such as hydrogen cyanide gas and carbon monoxide.

Abstract: A microchip for measuring platelet function by allowing blood to flow through a channel to induce platelet aggregation, wherein the microchip has a channel provided inside thereof, wherein at least a part of the channel is coated with collagen for allowing adhesion of platelets; a plurality of walls extend along the direction of the flow of blood in the channel and divide the width of the channel to form a channel dividing section; and the walls are treated to have a surface roughness (Ra) of 10 to 200 nm.

Abstract: A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber.

Abstract: A method is provided for fluid flow containment in an open liquid environment at least partially defined by a surface. The method includes the step of positioning a microfluidic device over the surface. The microfluidic device defines a chamber having a height. A flow of fluid is applied in the chamber. The pressure of the flow of fluid is monitored and the height of the chamber is determined from the measured pressure of the flow of fluid.

Abstract: The invention provides molecule-responsive gel particles which change in size in response to specific molecules and a method of production of the same. A polymer gel particle with a crosslinked structure has fixed thereto a plurality of clathrate compound-forming host molecules. Two or more of the plurality of host molecules clathrate different atomic groups in a target molecule so that the two or more host molecules and the target molecule can form a crosslink in the molecule-responsive gel particle.

Abstract: An apparatus and method for measuring augmented osmotic pressure in a reference cavity is provided, in which the device comprise a substrate frame (4) attached to a support structure (1) in which a plurality of transducer devices (2) are buried. An array of osmotic membranes (3) is integrated by the support structure and which acts to facilitate a trans-membrane pressure gradient as a function of the osmotic pressure change in a sealed cavity (7). The sealed cavity is formed by rigid substrate materials (5,6) in which the membranes, support structure and transducer devices only will be subject to induced stress in response to augmented osmotic pressure and thereby generate a pressure induced signal change observed from the transducer devices. The transducer devices may be arranged as piezoresistive elements, as micromechanical switches, as variable capacitive elements or as an optical light source and detector.

Abstract: An ozone gas concentration measurement method that can easily measure the concentration of ozone gas. A process gas containing ozone gas is produced from a raw gas containing oxygen gas. The number of moles of gas molecules contained in the process gas is measured. The concentration of the ozone gas contained in the process gas is calculated based on the number of moles of gas molecules contained in the process gas.

Abstract: System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a collected co-aggregate in the liquid, wherein the co-aggregate comprises a magnetic particle having a stimuli-responsive polymer attached thereto and a non-magnetic particle having a stimuli-responsive polymer and a diagnostic target attached thereto.

Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of an ion exchange resin-treated biological fluid sample are provided.

Abstract: A biodevice is in an elongated form and has a conductive layer and an insulating layer stacked on a side surface of a shaft member at the center. A cylindrical hollow section is formed through the device, being connected to the exterior at a front end and extending from this front end axially. An electrode section is formed on an inner surface. A sensing substance such as enzyme may be placed at the electrode section to detect a current value corresponding to the concentration or quantity of an object under test placed between a counter electrode and the biodevice.

Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of a surfactant-treated biological fluid sample are provided.

Abstract: A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber.

Abstract: A microfluidic circuit cartridge having 3-D hydrodynamic focusing. The cartridge may be fabricated with injection-molded or other molded layers providing a 3-D structure. A flow channel on the card may have a sample core flowing in a fluid of a flow channel for analysis. The sample core may be adjustable in position within the channel with one or more jets or channels of fluid being injected into the flow channel. The jets may also adjust the size of the sample core. There may be a hemoglobin measurement mechanism or card with a cuvette.

Abstract: A system and method for characterizing a liquid hydrocarbon fuel having unknown or variable composition is described and shown herein.

Abstract: An interactive security screening system includes a main housing, a contact or palm pad provided on the main housing and a sample sheet positioned upon the contact pad. A sensor is operatively connected to the contact pad to measure pressure applied to the contact pad during a sample collection process. A feedback system, operatively connected to the contact pad and the sensor, provides the subject or screener with at least one of a visual signal and an audio signal to indicate whether requisite pressure was applied to the contact pad. A sample processing system analyzes the sample collection sheet through series, parallel or image processing to determine whether the trace residue sample contains a threat residue. The screening system also employs a spatial recognition system that focuses the sample processing system on particular portions of the sample collection sheet to increase overall system accuracy.

Abstract: A changeable pipette tip includes a first end having a fluid opening and a second end having a pipe elastic in the radial direction having an orifice. The orifice and the fluid opening are in fluid connection. The first end is designed to be coupled to a matching coupling unit of a pipetting unit such that liquid may be sucked into the fluid area through the orifice by an actuating unit in the pipetting unit. In order to eject liquid as free-flying droplets or as a jet from the orifice of the pipe elastic in the radial direction, a volume change of a portion of the pipe elastic in the radial direction is effected.

Abstract: A device for measuring/determining a physical quantity of a medium. The device comprises a sensor part and an electronic part, whereby at least the electronic part is arranged inside a housing and at least one fuel cell is provided which at least partially covers the energy demand of the device.

Abstract: A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber.

Abstract: Provided is a dispensing device capable of removing bubbles reliably. In this dispensing device, deaerated water is fed by a water feed pump to the inside of a pipeline up to the vicinity of the leading end of a dispensing nozzle. A water feed valve disposed near a dispensing pump is closed to establish a deaerated water space opened on the leading end side of the dispensing nozzle. The dispensing pump is activated on the space, thereby causing the dispensing nozzle to perform suction and exhaust actions. The dispensing device comprises a vacuum means connected to the space through the water feed valve thereby maintaining a vacuum state. In case the deaerated water space is cleared of the bubbles, the cleared water space is brought, by opening a change-over valve, into communication with a pipeline having a vacuum means connected thereto, thereby bringing the space into the vacuum state.

Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.

Abstract: This invention relates generally to a new class of chemoselective polymer materials primarily designed to sorb hydrogen bond basic analytes such as organophosphonate esters (nerve agents and precursors) and nitro-substituted compounds (explosives). In particular, the invention relates to linear polycarbosilane compounds for use in various analytical applications involving sorbent polymer materials, including chromatography, chemical trapping, analyte collection, and chemical sensor applications.

Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.

Abstract: A system and method for measuring and analyzing particles within a gas feed stream. In one aspect, the system includes a particle counter and a particle capture filter that are arranged in parallel. In another aspect, the system includes a purifying device to remove trace molecular impurities from a gas feed stream to reduce the presence of impurities.

Abstract: A method and apparatus for measuring the presence or absence of reaction between a first and second material of interest by measuring osmotic pressure changes in a reaction cell. The reaction cell is capable of measuring the small changes in pressure that occur due to osmotic pressure shifts during a catalytic or binding reaction at species concentrations down to approximately 10?7 M.

Abstract: An instrument for carrying out controlled microwave assisted chemical processes, and that is particularly useful for handling relatively small samples. The instrument includes a microwave-transparent reaction vessel with an open mouth, a pressure-resistant seal on the mouth of the vessel, and a needle, portions of which penetrate the seal with a first end of the needle and provide fluid communication into the vessel. A pressure transducer is at the opposite end of the needle and in fluid communication with the interior of the vessel through the needle. The instrument defines a pressure control flow path from a portion of the needle outside of the vessel to a fluid port, the flow path being in communication with the needle, the interior of the vessel and the transducer. A controllable pressure release valve for the flow path is associated with the port.

Abstract: In a device for measuring the pressure of a medium, in particular a liquid medium, the device including a measuring chamber through which the medium can flow and which has at least one elastically deformable wall, at least one wall that is more rigid by comparison to the elastically deformable wall, and an inlet and outlet for the medium, at least one excitation electrode is provided in or on the at least one more rigid wall of the measuring chamber, and at least one signal electrode is provided on the elastically deformable wall, for impedance measurement.

Abstract: A dispensing apparatus performs dispensing by filling a duct to which a dispensing nozzle is connected with a liquid, making the liquid move in the duct to absorb a liquid sample including a specimen or a reagent through the dispensing nozzle, and discharging the absorbed liquid sample; and an in-duct bubble presence determining method in the dispensing apparatus. The presence determining method includes discharging the liquid in the duct from the dispensing nozzle and detecting a transition of a pressure in the duct; calculating the number of mountain pulses in a pressure transition waveform based on the detected pressure transition; and determining a presence of a bubble in the duct based on the calculated number of mountain pulses.

Abstract: A device is disclosed which is a highly sensitive and selective sensor. The device is comprised of a sensor material secured into a fixed position on substrate, a deformable arm and a signaling component which creates a detectable signal in response to movement of the arm. The sensitivity of the device is enhanced by using a sensor material which undergoes a dramatic change in volume which may be accompanied by a phase change in response contact with a target such a molecule of interest. The selectivity of the device is enhanced by incorporating highly specific binding receptors (e.g. antibodies) into the sensor material which receptors bind to specific targets (e.g. peptide epitopes). The binding of the target molecule to the receptor causes the sensor material to change dramatically in volume thereby moving the arm causing the signaling component (e.g. a piezoresistor) to create a detectable signal (e.g. change in resistance) thereby indicating the present of the target.

Abstract: A system, device and method for detection of several individual analytes in a test solution aliquot (83) with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station (100) that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (10), each containing a piezoelectric crystal (50) carrying electrodes (56,62) and a coating (66,46) exposing a first member of an interaction pair specific for an individual analyte being a second member of the interaction pair. Flowing means (70) flows a solution (75) and the test solution aliquot (83) to and through a cell compartment of each of the cells (10) via the connecting station (100). Power and measurement means (130) oscillate the piezoelectric crystal(s) (50). A change in oscillating characteristics of the crystal(s) (50), following interaction between the first and second members of the interaction pair, detects presence of the individual analyte(s).

Abstract: The invention provides molecule-responsive gel particles which change in size in response to specific molecules and a method of production of the same. A polymer gel particle with a crosslinked structure has fixed thereto a plurality of clathrate compound-forming host molecules. two or more of the plurality of host molecules clathrate different atomic groups in a target molecule so that the two or more host molecules and the target molecule can form a crosslink in the molecule-responsive gel particle.

Abstract: Gas flow is controlled to a feed gas consuming device depending on whether a contaminant gas is present. In one embodiment, hydrogen gas flow from a hydrogen gas generator to a hydrogen consuming device, such as a fuel cell, gas chromatograph or a flame ionization detector, is terminated when there is chemical contaminant breakthrough in the hydrogen gas flow. The apparatus relates to the use of a sensor for detecting a predetermined concentration of a chemical contaminant such as ammonia. In one embodiment the apparatus terminates the gas flow when a concentration of ammonia in the gas flow corresponds to a breakthrough (e.g., approximately in the range of 2.0% or greater). The apparatus prevents the ammonia-contaminated hydrogen from disabling such a hydrogen consuming device that would have otherwise received the contaminated gas flow.

Abstract: A preferred method for determining the flow fraction of a mixture of water, gas and oil in a hydrocarbon reservoir includes measuring pressure and density of the mixture over time, determining a function which approximates a relationship between the density and pressure measurements, calculating a derivative of the function over time, and determining flow fraction based, in part, on the derivative. Preferably, transient data points are eliminated and the remaining set of data points are weight averaged to improve signal to noise ratio. Bubble point pressure, bubble point density and molecular weight and density of the liquid portion of the mixture are also used in the determination.

Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.

Abstract: The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid (CSF) samples. The reagent compositions sphere and fix all cells in the sample in suspension. Reported results can include red blood cell (RBC) and white blood cell (WBC) counts, WBC differential values, cell-by-cell volumes and dry-mass concentrations.

Abstract: A method and apparatus for measuring the presence or absence of interaction between at least a first and second material of interest by measuring osmotic pressure changes in an osmotic cell. Changes in osmotic pressure are determined by measuring the amount of compression exhibited by a compressible, semi-permeable material positioned in the cell.

Abstract: A method and apparatus for measuring the presence or absence of reaction between a first and second material of interest by measuring osmotic pressure changes in a reaction cell. The reaction cell is capable of measuring the small changes in pressure that occur due to osmotic pressure shifts during a catalytic or binding reaction at species concentrations down to approximately 10?7 M.

Abstract: Methods for detecting cardiac injury by detecting one or more cardiac markers are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for a cardiac marker, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.

Abstract: The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts.

Abstract: The invention relates to a method for monitoring exothermic reactions in a reactor, in which one or more starting materials react exothermically to give at least one product, and at least one gas is present in the reactor during operation as intended or during a runaway, comprising the following process: A) measurement and storage of an initial temperature and an initial pressure in the reactor, B) calculation of the amount of products and starting materials present in the reactor from an energy balance, C) calculation of a maximum pressure raise that occurs on stepwise reaction of the amount of starting materials present, and D) calculation of a runaway pressure from the maximum pressure raise that occurs, calculated in step C), and the measured initial pressure stored in step A).

Abstract: An apparatus and method for detecting an analyte wherein a member may respond to mechanical stress induced by a volume change of a sensitive hydrogel upon sensing an analyte and wherein the mechanical stress may be detected by a detector.

Abstract: A method and apparatus for measuring the presence or absence of reaction between a first and second material of interest by measuring osmotic pressure changes of reaction detector. The reaction detector is capable of measuring the small changes in pressure that occur due to osmotic pressure shifts during a catalytic or binding reaction at species concentrations down to approximately 10?7 M.

Abstract: The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the blood in the passageway to detect the platelet mass. The flow and composition change in response to the formation of a platelet mass in the passageway. Devices, articles, and kits for performing the methods are also disclosed.

Abstract: Described is apparatus and a process for the enablement of functional product analysis of the headspace proximate one or more substrate, such as hair, fabric or skin, surfaces having affixed thereto functional product, a fragrance composition and/or malodor counteractant composition-containing microcapsules. The apparatus employs mobile microcapsule-abrading solid objects, including agitating stainless steel spheres during analyte collection in a gas-flow/trapping tube analyte collection apparatus. The reciprocating motion and the air-flow are commenced simultaneously thereby enabling the solid objects to become mobile and to effectively abrade the microcapsules affixed to the semi-solid surfaces.

Abstract: A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood receptacle that is open to the atmosphere into which a blood sample is to be deposited, a vacuum port that is open to atmosphere, and a spiral capillary within the test cartridge having a capillary length and cross-section area, a first capillary end of the spiral capillary open to the blood receptacle and a second capillary end of the spiral capillary open to the vacuum port, whereby the spiral capillary is closed to atmosphere. When a blood sample is deposited in the blood receptacle, a vacuum is drawn through the vacuum port and the blood is drawn through the spiral capillary until coagulation occurs. A pressure change is detected, and the coagulation time is measured.