Measurement Includes Change In Volume Or Pressure Patents (Class 436/148)
  • Patent number: 7364912
    Abstract: Gas flow is controlled to a feed gas consuming device depending on whether a contaminant gas is present. In one embodiment, hydrogen gas flow from a hydrogen gas generator to a hydrogen consuming device, such as a fuel cell, gas chromatograph or a flame ionization detector, is terminated when there is chemical contaminant breakthrough in the hydrogen gas flow. The apparatus relates to the use of a sensor for detecting a predetermined concentration of a chemical contaminant such as ammonia. In one embodiment the apparatus terminates the gas flow when a concentration of ammonia in the gas flow corresponds to a breakthrough (e.g., approximately in the range of 2.0% or greater). The apparatus prevents the ammonia-contaminated hydrogen from disabling such a hydrogen consuming device that would have otherwise received the contaminated gas flow.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: April 29, 2008
    Inventors: Jeffrey A. Schmidt, Franklin Earl Lynch, John S. Wilkes
  • Patent number: 7309607
    Abstract: The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the blood in the passageway to detect the platelet mass. The flow and composition change in response to the formation of a platelet mass in the passageway. Devices, articles, and kits for performing the methods are also disclosed.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: December 18, 2007
    Assignee: PlaCor Inc.
    Inventor: Daniel G. Ericson
  • Patent number: 7282367
    Abstract: A verification method of a sample solution amount includes the steps of: detecting at least one of a transmitted light component, a scattered light component and a reflected light component of a light by a photosensor while irradiating a sample solution, which is being injected into a sample cell, with the light; and verifying that a predetermined amount of the sample solution is held in the sample cell based on a change in an output signal from the photosensor.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: October 16, 2007
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventor: Tatsurou Kawamura
  • Patent number: 7282372
    Abstract: A method for measuring the amount of fluid contained in a reaction vessel in a clinical analyzer includes the steps of adding a first aliquot of fluid to the reaction vessel and measuring the quantity of fluid contained therein. A second aliquot of fluid is then added to the reaction vessel and the quantity of fluid contained therein is also measured. Measurement of the two fluid quantities can occur with or without removal of the first aliquot in between measurements. In obtaining the two quantity measurements and comparing them against a standard, the effects of well geometry can be minimized. Preferably, a delta or ratio measurement is obtained between the first and second liquid volume measurements which can be compared against a standard so as to normalize apparent volume losses or gains due to reaction well dimensional variation. This approach enhances the analytical capability to detect true fluid delivery errors.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: October 16, 2007
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Nicholas VanBrunt, Randy K. Bower, Robert A. Burkovich, Joseph J. Dambra
  • Patent number: 7204960
    Abstract: The invention provides an apparatus and method for calibrating a dispensing system. A dispenser dispenses a controlled quantity of material into a container for receiving material. A system, preferably a vision system comprising an image capturing device and an imaging system, is adapted to capture an image of a physical dimension of a quantity of dispensed material in a given time. The physical dimension may be a width of a top surface area, a height or a cross-sectional area of the dispensed material. A calibrating system is adapted to calculate a volume of the quantity of material based upon said physical dimension.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: April 17, 2007
    Assignee: ASM Assembly Automation Ltd.
    Inventors: Hon Chiu Hui, Wing Fai Lam, Lim Pun Kong, Ka Yee Mak, Ka Yin Lee
  • Patent number: 7189575
    Abstract: Disclosed is a method for determining the swellability and the swelling kinetics of superabsorbent material (9) such as polymer gels, for example, which comprises introducing a defined volume of the dry superabsorbent material (9) into a measuring vessel (7), using a movable element (4) within said measuring vessel (7) to apply a restraining force (12) to said superabsorbent material (9) and capturing the expansion of said superabsorbent material (9) contactlessly within a chamber (14) in a continuous manner by capturing the change in height of a piston (4) which bounds said chamber (14), travels in a measuring vessel (7) and is marked with a height scale (6).
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: March 13, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Schrof, Udo Gödert, Martin Beck, Hans-Joachim Hähnle, Gunnar Schornick
  • Patent number: 7157052
    Abstract: This invention relates generally to a new class of chemoselective polymer materials. In particular, the invention relates to linear polycarbosilane compounds for use in various analytical applications involving sorbent polymer materials, including chromatoghraphy, chemical trapping, analyte collection, and chemical sensor applications.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: January 2, 2007
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Robert A. McGill, Eric J. Houser
  • Patent number: 7153695
    Abstract: The present invention relates to a method for titration comprising guiding a sample to be titrated through a conduit, adding a reagent to said conduit at at least two entrance positions along said conduit in such a manner that said reagent will react with the sample within at least one individual sector of the conduit, defined as the space between two consecutive entrance positions or a final individual sector defined between a final entrance position and a sample exit point of the conduit, while at least one detection device positioned at the end of each sector of said conduit register the chemical and/or physical status. A pressure difference is provided between the reagent delivery device and the sample conduit such that the pressure difference measured between the reagent delivery device and the end of the final individual sector is controlled to be greater than the total pressure drop between the sample delivery point and the end of the final individual sector.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: December 26, 2006
    Assignee: Akzo Nobel N.V.
    Inventors: Johan Roeraade, Matthew Rice
  • Patent number: 7144739
    Abstract: A pressure-sealing, pressure-monitoring closure for non-invasively sealing a reaction vessel to a defined release pressure in microwave-assisted chemistry is disclosed. The closure includes a pressure-resistant, microwave-transparent reaction vessel, one portion of which defines a mouth, a flexible pressure-transmitting releasable cover assembly on the mouth of the vessel, a pressure transducer on the cover and external to the vessel for monitoring the pressure in the vessel as exerted against the flexible cover, and a clamp for urging the vessel, the cover and the transducer together under a defined force so that when the pressure in the vessel exceeds the defined force, the cover can flex and release the pressure from the vessel.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: December 5, 2006
    Assignee: CEM Corporation
    Inventor: William E. Jennings
  • Patent number: 7077234
    Abstract: A rack-and-pinion assembly comprises a housing, a rotatable pinion gear including a plurality of teeth, and at least one moveable mount for providing a moveable attachment of the housing to the vehicle. A rack is slidably positioned within the housing and includes a plurality of teeth corresponding to the pinion teeth. A tie rod is operably attached to one of two ends of the rack, and may also be attached to a first wheel. A cross car link is operably attached to the first wheel and a second wheel. Rotation of the pinion gear causes translational movement of the rack and tie rod relative to the housing, which may thereby turn the first wheel. The first front wheel cooperates with the cross car link to simultaneously turn the second wheel, and the housing moves with respect to the vehicle as the first and second wheels turn.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: July 18, 2006
    Assignee: DaimlerChrysler Corporation
    Inventors: Matthew E Klais, Nicholas Rosenthal, William J Thomas
  • Patent number: 7029921
    Abstract: An apparatus for continuous on-line measurement of chemical composition of aerosol particles with a fast time resolution is provided. The apparatus includes an enhanced particle size magnifier for producing activated aerosol particles and an enhanced collection device which collects the activated aerosol particles into a liquid stream for quantitative analysis by analytical means. Methods for on-line measurement of chemical composition of aerosol particles are also provided, the method including exposing aerosol carrying sample air to hot saturated steam thereby forming activated aerosol particles; collecting the activated aerosol particles by a collection device for delivery as a jet stream onto an impaction surface; and flushing off the activated aerosol particles from the impaction surface into a liquid stream for delivery of the collected liquid stream to an analytical instrument for quantitative measurement.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: April 18, 2006
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Yin-Nan E. Lee, Rodney J. Weber, Douglas Orsini
  • Patent number: 6989237
    Abstract: The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in said sample binds to the corresponding binding partner. The sample is then transported beyond the binding partner(s), followed by detection of any target analyte bound to each binding partner. In one embodiment, binding efficiency is increased by the use of segmented transport, wherein a first bolus or bubble of a fluid that is immiscible with the sample precedes the sample during transport and a second bolus or bubble of a fluid that is immiscible with the sample follows the sample. Many configurations are possible for the device of the invention.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: January 24, 2006
    Assignee: The Regents of the University of California
    Inventors: Mack J. Fulwyler, Joe W. Gray
  • Patent number: 6924149
    Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: August 2, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Howard Turner, G. Cameron Dales, Lynn VanErden, Johannes A. M. Van Beek, Damian A. Hajduk, Ralph B. Nielsen, William C. Rust
  • Patent number: 6835553
    Abstract: An implantable biosensor for detecting an analyte in vivo in body fluids comprises an analyte-sensitive hydrogel filament chemically configured to vary its displacement volume according to changes in concentration of an analyte, such as glucose, in a patient's body fluid. A photometric displacement transducer placed inside the biosensor is configured to quantifiably detect changes in the displacement volume of the hydrogel filament, such as by detecting the light intensity on a photoreceptor arranged to receive light of varying intensity depending upon the displacement of the hydrogel filament. A battery powered telemeter operably engaged to the photometric displacement transducer sends a radio data signal representing glucose concentration level to a receiver containing an alarm system. The alarm system can automatically notify a person that the analyte level is outside desired predetermined parameters, and/or to automatically inject an agent to counteract the adverse analyte levels.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: December 28, 2004
    Assignee: M-Biotech, Inc.
    Inventors: In Suk Han, Seok Lew, Man Hee Han
  • Patent number: 6794194
    Abstract: A method for measuring the hemoglobin concentration in the blood in a circuit of a dialysis machine includes directing electromagnetic waves against one section of the circuit, measuring values of the electromagnetic waves transmitted through the section, and determining values of absorption of electromagnetic waves by the blood along the section from the measured values of transmitted electromagnetic waves. The values of absorption are correlated with the values of the hemoglobin concentration. The method also includes measuring the values of at least one physical quantity of the blood, wherein the at least one physical quantity is selected from blood pressure and blood temperature, and calculating the values of hemoglobin concentration as a function of the values of absorption and the at least one physical quantity.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: September 21, 2004
    Assignee: Gambro Dasco SpA
    Inventors: Massimo Fava, Annalisa Delnevo, Francesco Paolini
  • Patent number: 6750062
    Abstract: The invention concerns the study of the effect of a supercritical fluid on the transitions of a material, which consists in varying continuously or by stages according to a predetermined programme, a first parameter value selected among the super-critical fluid pressure, the temperature of a cell containing the material sample and said sample volume, while maintaining a second of said parameters at a value selected, so as to induce the transition; and in recording the variation of the first parameter, that of the third parameter and the heat flow rate in the cell; in comparing said recordings with those obtained by replacing the supercritical fluid with a neutral fluid. The figure shows a diagram of the device for carrying out said study. The invention is in particular useful for studying a polymer material transitions.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: June 15, 2004
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Stanislaw L. Randzio, Jean-Pierre E. Grolier
  • Publication number: 20040101441
    Abstract: A pressure-sealing, pressure-monitoring closure for non-invasively sealing a reaction vessel to a defined release pressure in microwave-assisted chemistry is disclosed. The closure includes a pressure-resistant, microwave-transparent reaction vessel, one portion of which defines a mouth, a flexible pressure-transmitting releasable cover assembly on the mouth of the vessel, a pressure transducer on the cover and external to the vessel for monitoring the pressure in the vessel as exerted against the flexible cover, and a clamp for urging the vessel, the cover and the transducer together under a defined force so that when the pressure in the vessel exceeds the defined force, the cover can flex and release the pressure from the vessel.
    Type: Application
    Filed: November 26, 2002
    Publication date: May 27, 2004
    Applicant: CEM Corporation
    Inventor: William Edward Jennings
  • Patent number: 6716642
    Abstract: The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: April 6, 2004
    Assignee: Aviva Biosciences Corporation
    Inventors: Lei Wu, Xiaobo Wang, Jing Cheng, Weiping Yang, YuXiang Zhou, LiTian Liu, Junquan Xu
  • Patent number: 6703241
    Abstract: Devices and methods are disclosed that are effective to produce reliable vapor measurements in the presence of drift. In certain instances the sensor module is mounted externally on a housing. In other instances, the sensor module contains a first sensor element incorporating a first array of sensors and a second sensor element incorporating a second array of sensors wherein both sensor elements are mounted externally on the housing. In other embodiments, the present invention relates to mapping an x-y surface for detection of an analyte, the method includes moving in tandem at least two sensor arrays separated by a distance “d” across an x-y surface to produce a plurality of responses and analyzing the responses to map the x-y surface for detection of an analyte. Moreover, the present invention provides a sensor module, such as in a handheld device, comprising at least two pneumatic vapor paths and at least two sensor arrays.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: March 9, 2004
    Assignee: Cyrano Sciences, Inc.
    Inventors: Steven A. Sunshine, Bruce Hermann, Beth C. Munoz
  • Publication number: 20040043500
    Abstract: An apparatus and system for wafer-scale microwave digestion of layers or structures from a large-scale semiconductor substrate include a digestion vessel with a chamber which is configured to receive a whole large-scale semiconductor substrate, such as a silicon wafer. The digestion vessel may be configured to be placed within a containment apparatus, which structurally supports the digestion vessel. A digestion method includes placing at least one large-scale semiconductor substrate within the digestion vessel with a polar solvent, placing the digestion vessel within the containment apparatus, placing the containment apparatus in a microwave oven or other microwave source, and heating the polar solvent and substrate with microwaves. The heated polar solvent dissolves one or more desired layers or structures and may be subsequently analyzed to evaluate the amounts of one or more materials of such layers or structures.
    Type: Application
    Filed: August 27, 2002
    Publication date: March 4, 2004
    Inventors: J Eric Rumps, Ronald F. Baldner
  • Patent number: 6692970
    Abstract: A method and apparatus are provided for measuring the gas efflux from a substrate. In particular, one or more measuring chambers receive a gas enriched air from the substrate. A respiration system sends reference air having a known gas concentration to the measuring chamber. The reference air mixes with the gas enriched air to form a mixed air, which is returned to the respiration system. The respiration system then measures the gas efflux of the substrate over the given amount of time.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: February 17, 2004
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: John R. Butnor, Christopher A. Maier, Kurt H. Johnsen
  • Patent number: 6689613
    Abstract: A combinatorial method is provided for the preparation and screening of heterogeneous catalysts. The method comprises the steps of: (I) providing a library of elemental catalysts; (II) reacting the catalysts with a carbon source to form product directly on the catalyst; and (III) screening the products to evaluate the catalysts.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: February 10, 2004
    Assignee: General Electric Company
    Inventors: Xiao-Dong Sun, Navjot Singh
  • Patent number: 6660230
    Abstract: This invention relates generally to a new class of chemoselective polymer materials. In particular, the invention relates to linear polycarbosilane compounds for use in various analytical applications involving sorbent polymer materials, including chromatoghraphy, chemical trapping, analyte collection, and chemical sensor applications.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: December 9, 2003
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Robert Andrew McGill, Eric J. Houser
  • Publication number: 20030199099
    Abstract: An instrument is disclosed for carrying out controlled microwave assisted chemical processes, and that is particularly useful for handling relatively small samples. The instrument includes a microwave-transparent reaction vessel with an open mouth, a pressure-resistant seal on the mouth of the vessel, and a needle, portions of which penetrate the seal with a first end of the needle and provide fluid communication into the vessel. A pressure transducer is at the opposite end of the needle and in fluid communication with the interior of the vessel through the needle. The instrument defines a pressure control flow path from a portion of the needle outside of the vessel to a fluid port, the flow path being in communication with the needle, the interior of the vessel and the transducer. A controllable pressure release valve for the flow path is-associated with the port.
    Type: Application
    Filed: April 19, 2002
    Publication date: October 23, 2003
    Inventors: Edward Earl King, James Edward Thomas
  • Publication number: 20030148527
    Abstract: A method of treating of hydrotest water inhibits oxygen corrosion, inhibition of MIC and safe discharge of water. The combination treatment plan reduces biocide usage in a high pH brine. The reduced overall chemical usage facilitates meeting environmental guidelines while also minimizing chemical cost. The method comprises adding an oxygen scavenger to remove oxygen and prevent or minimize oxygen corrosion; raising the hydrotest water pH, typically in excess of pH 9.5; adding a biocide in reduced amount; and adding a scale inhibitor to inhibit scale.
    Type: Application
    Filed: November 13, 2002
    Publication date: August 7, 2003
    Inventor: Rupi Prasad
  • Publication number: 20030082825
    Abstract: An apparatus for continuous on-line measurement of chemical composition of aerosol particles with a fast time resolution is provided. The apparatus includes an enhanced particle size magnifier for producing activated aerosol particles and an enhanced collection device which collects the activated aerosol particles into a liquid stream for quantitative analysis by analytical means. Methods for on-line measurement of chemical composition of aerosol particles are also provided, the method including exposing aerosol carrying sample air to hot saturated steam thereby forming activated aerosol particles; collecting the activated aerosol particles by a collection device for delivery as a jet stream onto an impaction surface; and flushing off the activated aerosol particles from the impaction surface into a liquid stream for delivery of the collected liquid stream to an analytical instrument for quantitative measurement.
    Type: Application
    Filed: October 24, 2002
    Publication date: May 1, 2003
    Inventors: Yin-Nan E. Lee, Rodney J. Weber, Douglas A. Orsini
  • Publication number: 20030036052
    Abstract: The present invention provides methods and sensors for assaying components of fluid samples by measuring pressure changes. In particular, the invention provides methods to assay for components in fluids with or without the aid of enzymatic reactions. The invention also provides a modified sensor that has an immersible pressure monitor/gas-containing portion unit and is capable of detecting pressure changes with higher sensitivity.
    Type: Application
    Filed: July 30, 2002
    Publication date: February 20, 2003
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael J. Delwiche, Daniel M. Jenkins, Edward J. DePeters, Robert H. BonDurant
  • Patent number: 6506609
    Abstract: Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: January 14, 2003
    Assignee: Caliper Technologies Corp.
    Inventors: H. Garrett Wada, Anne R. Kopf-Sill, Marja Liisa Alajoki, J. Wallace Parce, Benjamin N. Wang, Andrea W. Chow, Robert S. Dubrow
  • Publication number: 20020192831
    Abstract: A method of controlling the hydrocarbon content of a possible explosive mixture of air/hydrocarbon vapor circulating from an intake point into an installation fitted with a vapor intake system comprising a vapor intake circuit incorporating a suction pump enabling vapor to be circulated at a vapor flow rate QV. A device is connected to the vapor intake circuit to determine the hydrocarbon content of the aspirated vapor comprising a combination of a flow meter on the one hand and a sensor for measuring relative pressure by reference to atmospheric pressure PA on the other. The hydrocarbon content of the vapor circulating in the vapor intake circuit is determined by taking account of the density and the viscosity of this vapor, which is derived on the basis of a characteristic linked to the loss in air pressure previously stored in memory.
    Type: Application
    Filed: January 30, 2002
    Publication date: December 19, 2002
    Inventor: Jacques Fournier
  • Patent number: 6475750
    Abstract: A biosensor (10) has a hydrogel (30) in a rigid and referably biocompatible enclosure (20). The hydrogel (30) includes an immobilized glucose-binding molecule such as concanavalin A (Con A) and an immobilized hexose saccharide such as a-D-mannopyranoside. The immobilized hexose saccharide competitively binds with free glucose to the glucose-binding molecules, thus changing the number of crosslinks in the hydrogel (30), which changes hydrogel swelling tendency and the pressure of the hydrogel in its confined space in proportion to the concentration of free glucose. By measuring the change in hydrogel pressure with a pressure transducer (40), the biosensor (10) is able to accurately measure the concentration of the tree glucose molecule without the problem of oxygen limitations and interference encountered by prior art biosensors.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 5, 2002
    Assignee: M-Biotech, Inc.
    Inventors: In Suk Han, You Han Bae, Dal Young Jung, Jules John Magda
  • Publication number: 20020132361
    Abstract: The invention relates to a nanoparticle film comprising a nanoparticle network formed of nanoparticles interlinked by linker molecules. The linker molecules have at least two linker units that can bind to the surface of the nanoparticles. By introducing selectivity-enhancing units in the linker molecule, the selectivity of the nanoparticle film towards target analytes can be enhanced. A fine-tuning of the selectivity can be achieved by including a fine-tuning unit in the vicinity of the selectivity-enhancing unit. The nanoparticle film can be used to produce chemical sensors which are selective and stable in their performance.
    Type: Application
    Filed: December 11, 2001
    Publication date: September 19, 2002
    Inventors: Tobias Vossmeyer, Isabelle Besnard, Jurina Wessels, William E. Ford, Akio Yasuda
  • Publication number: 20020110921
    Abstract: A method of analyzing the pores of a microporous material, the method comprising the following steps:
    Type: Application
    Filed: November 13, 2001
    Publication date: August 15, 2002
    Inventors: Jacobus Nicolaas Louwen, Robert Jan Jonker
  • Patent number: 6420187
    Abstract: The present invention is an improvement to the method and apparatus for measuring volatile compounds in an aqueous solution. The apparatus is a chamber with sides and two ends, where the first end is closed. The chamber contains a solution volume of the aqueous solution and a gas that is trapped within the first end of the chamber above the solution volume. The gas defines a head space within the chamber above the solution volume. The chamber may also be a cup with the second end. open and facing down and submerged in the aqueous solution so that the gas defines the head space within the cup above the solution volume. The cup can also be entirely submerged in the aqueous solution. The second end of the. chamber may be closed such that the chamber can be used while resting on a flat surface such as a bench. The improvement is a sparger for mixing the gas with the solution volume. The sparger can be a rotating element such as a propeller on a shaft or a cavitating impeller.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: July 16, 2002
    Assignee: Battelle Memorial Institute
    Inventors: Tyler J. Gilmore, Kirk J. Cantrell, George R. Holdren, Jr.
  • Patent number: 6395557
    Abstract: The invention relates to a method for determining an analyte in a solution. This method includes the following steps: a) fixing and immobilizing said analyte, for example via the presence of a ligand L, on the inner surface of a conduit (3) having a reduced cross section over all or part (9) of it, and b) determining the variation in load loss of a fluid circulating inside the conduit, due to the analyte P which has been fixed and immobilized at least in the reduced cross section part (9) of said conduit during step a).
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: May 28, 2002
    Assignees: Commissariat a L'Energie Atomique, Biomerieux SA
    Inventors: Yves Fouillet, Alain Theretz, Agnès Perrin
  • Patent number: 6311546
    Abstract: A biofouling monitor is described which has a column having an inlet and an outlet; a microorganism nutrient feed line located upstream of the inlet; and a first pressure sensor located upstream of the inlet for measuring flow pressure and a second pressure system located downstream of the outlet for measuring flow pressure. Also described is a biofouling monitor which further has a recirculation system and optionally inert packing material located in the column. A method to monitor or detect biofouling ahead of time in an aqueous system is further described.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: November 6, 2001
    Assignee: Buckman Laboratories International, Inc.
    Inventors: Wayne H. Dickinson, Thomas E. McNeel, Richard A. Clark, E. Van Haute
  • Patent number: 6245571
    Abstract: The invention relates to the study and the manufacture of lubricants used in particular in diesel engines. According to the invention, the neutralization capacity of a lubricant comprising detergent additives is determined by a method which consists in reacting, in a leaktight tank, at a constant temperature, the bases contributed by the additives present in a lubricant film of known mass with a predetermined amount of a liquid acid and in recording, as a function of the time, the values of the pressure within the leaktight tank, and in then determining, from the recorded values of the pressure, at lest one of the following three characterizing parameters: an initiation period for the reaction, a neutralization potential and a reaction rate. The invention finds its application in research and control laboratories of manufacturers of lubricants and in those of engine manufacturers.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: June 12, 2001
    Assignee: Elf Antar France
    Inventor: Jean-Philippe Roman
  • Patent number: 6087181
    Abstract: The present invention discloses a method for improving the speed and sensitivity of optical spectroscopic techniques for remote detection of trace chemical species in a carrier gas. The disclosed method can be applied to any optical spectroscopic detection technique whose sensitivity decreases as the total pressure of the sample decreases. The method employs an inert and non-absorbing buffer gas to supplement the pressure exerted by the carrier gas. This ensures that the total pressure of the sample, and hence sensitivity of the detection technique, remains high. The method is especially useful when measuring concentration of chemical species produced at small rates, and therefore should prove useful for rapid serial screening of combinatorial libraries of compounds.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: July 11, 2000
    Assignee: Symyx Technologies
    Inventor: Pejun Cong
  • Patent number: 6086826
    Abstract: A microwave vessel system for external and noninvasive pressure monitoring and control is disclosed. The system comprises a reaction vessel formed of a material that is transparent to microwave radiation, with the reaction vessel including a portion that is movable under pressure generated by a chemical reaction inside the vessel while maintaining the reaction sealed inside the vessel. A sensor is adjacent to the movable portion of the vessel for detecting the motion of the movable portion as the portion responds to pressure generated inside the vessel. The system includes a structure for maintaining the sensor against the movable portion while microwaves are applied to the vessel so that the movement of the movable portion under pressure is detected by the sensor.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: July 11, 2000
    Assignee: CEM Corporation
    Inventors: James Edward Thomas, Wyatt Price Hargett, Jr., Edward Earl King
  • Patent number: 6022747
    Abstract: A blood clot detector includes a pressure transducer on an aspiration line to provide output voltage data to a microprocessor corresponding to the vacuum level during aspiration. The microprocessor integrates the vacuum readings over time during the aspiration cycle to provide a pressure integral for each test sample aspiration. A pressure integral is determined for an unclotted aspiration and used as a reference for comparison with the pressure integrals of each test sample aspiration to determine whether a blood clot has interfered with the test sample aspiration. A valve is provided across an analytical line and an aspiration line to provide selective communication between the aspiration line and the analytical line or to prevent such communication. Communication between the aspiration line and the analytical line permits transfer of a test sample from the aspiration line to the analytical line if the test sample is considered acceptable for sample analysis.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: February 8, 2000
    Assignee: Bayer Corporation
    Inventors: Paul Gherson, Robert William Eherts, Theodore Pernicano
  • Patent number: 6004819
    Abstract: This invention relates to the measurement of various haemostatis, clotting, and the like properties of blood.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: December 21, 1999
    Assignee: Xylum Corporation
    Inventors: Peter Gorog, Iren Kovacs
  • Patent number: 5985356
    Abstract: Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: November 16, 1999
    Assignees: The Regents of the University of California, Symyx Technologies
    Inventors: Peter G. Schultz, Xiaodong Xiang, Isy Goldwasser
  • Patent number: 5980829
    Abstract: A neutralization testing apparatus and a neutralization testing method which allow a neutralization reaction rate of a liquid sample such as lubricant oil to be accurately measured are provided. Reagent injecting device for injecting a reagent which neutralizes the liquid sample is provided on a lid member of a closed container into which the liquid sample is charged. The reagent injecting device is an acid injecting port which penetrates through the closed container and an air-tight sealing member which closes the acid injecting port and which permits an injector needle for injecting the reagent to penetrate therethrough. Because no gas leakage occurs even when the injector needle is penetrated because of the elasticity of the air-tight sealing member, the measuring conditions within the closed container do not change and the neutralization reaction rate may be found accurately.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: November 9, 1999
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventor: Tadashi Katafuchi
  • Patent number: 5925569
    Abstract: This invention relates to the measurement of various haemostatis, clotting, and the like properties of blood.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: July 20, 1999
    Assignee: Xylum Corporation
    Inventors: Peter Gorog, Iren Kovacs
  • Patent number: 5854077
    Abstract: A method for continuously measuring particulate nitrate in a gas sample, comprising the steps of passing the gas sample through an inertial impactor with a 50% cut off at 2.5 microns, removing ambient pollutant gases from the gas with diffusion denuders, passing the gas through a first path so as to contact the gas with a coated filter so as to convert particulate nitrate to nitric acid vapor or passing the gas through a second path so as to contact the gas with coated filters to trap particulate nitrate and ammonia, and measuring nitric acid vapor and residual ambient pollutant gases produced from the first path and residual ambient pollutant gases produced from the second path with a chemiluminescent monitor, the difference in the signal produced from the gases from the two paths being a measurement of the particulate nitrate in the gas sample.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: December 29, 1998
    Assignee: President and Fellows of Harvard College
    Inventors: Jack Mikhail Wolfson, Petros Koutrakis
  • Patent number: 5770153
    Abstract: An analytical device for determining the gas consumption of matter, specifically the oxygen demand of organic matter includes a container for holding the sample which is to be analyzed and a cop to seal the container gas-tight. Electrical and/or electronic measurement components are integrated in the cap. These components include an electrical pressure sensor which communicates with the interior of the container through a pressure connection, electronic measuring circuitry to which the pressure sensor output signal is sent in order to calculate a value which is proportional to gas consumption, keys for operating the electronic measuring circuitry, and a display for displaying measured, calculated, or stored values. The cap also contains a power source for the electrical/electronic components.
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: June 23, 1998
    Assignee: WTW Wissenschaftlich-Technische Werkstatten GmbH
    Inventor: Ingeborg Wagner
  • Patent number: 5770152
    Abstract: A device and method for the detection of small particles in a fluid. The device is a collapsible sample container having a opening which is covered, at least in part, by a porous membrane having a plurality (e.g., 100) of pores therein having a pore diameter equal to or smaller than the diameter of the particles to be detected (e.g., 01. to 100 microns). A means for collapsing the container to extrude the liquid sample through the membrane pores is provided along with a means for detecting pressure during the extrusion. The size and number of particles in the liquid is calculated by relating the extrusion pressure required to a pre-calibrated standard. When a constant pressure is applied the rate at which fluid is extruded decreases as the pores of the membrane become clogged with particles.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: June 23, 1998
    Assignee: Aradigm Corporation
    Inventors: Jeffrey A. Schuster, Peter M. Lloyd, Igor Gonda, David Cipolla
  • Patent number: 5759862
    Abstract: The heating value of a sample gas is calculated by a microcontroller from the heating value of a reference gas, and from flow ratios determined as the gas is consumed by catalytic combustion. The combustible gas is mixed with a combustion supporting gas, such as air, and flowed to a catalytic apparatus. In one embodiment, a molar flow meter is connected in the supply line for the combustible gas to measure the molar flow rate of a reference gas and a sample gas. Molar flow rates of the reference gas and the sample gas are determined at maximum temperature of combustion of the gas. In a preferred embodiment, a valve chamber is charged with a gas to a predetermined pressure and then discharged. During the discharge cycle, the apparatus senses the maximum temperature of combustion which corresponds to the point of optimum fuel-to-air ratio for catalytic combustion.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: June 2, 1998
    Assignee: Badger Meter, Inc.
    Inventors: William H. Vander Heyden, Ronald Arthur Berg
  • Patent number: 5731164
    Abstract: This invention provides a process for checking the removal rate of pyrogenic substances, in particular viruses, from organic material. The material to be purified is passed through an ultrafilter or an ultrafiltration unit whose virus-removal rate has already been determined by passing viruses of the Leviviridae family or other comparable small bacteriophages through the filter or filtration unit, the virus titer is determined before and after the filtration operation and the virus removal rate thus calculated. Before or after determining the virus-removal rate, a given pressure is applied to the filter or filtration unit in a gas pressure-hold test, and the decrease in the pressure over a given period is measured. After filtration of the biological material, the rate of virus removal by the filter is checked by repeating the pressure-hold test.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 24, 1998
    Assignee: Sanorell Pharma GmbH & Co.
    Inventors: Gerhard Becker, Paul Marcel Larson, Reiner Heidl
  • Patent number: 5712168
    Abstract: A method for evaluating, monitoring or controlling the efficiency, stability or exhaustion of a complexing or chelating agent present in a chemical solution used for oxidizing, dissolving, etching or stripping a semiconductor wafer wherein:a chemical solution containing hydrogen peroxide as well as a complexing or chelating agent for contaminants present in the solution is used for oxidation, dissolution, etching or stripping a semiconductor wafer surface;a measurement of the hydrogen peroxide decomposition is performed in situ in the solution;the measurement of the H.sub.2 O.sub.2 decomposition is used to provide information concerning the behavior of the complexing or chelating agent.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: January 27, 1998
    Assignee: IMEC
    Inventors: Harald Okorn Schmidt, Martien Johanna Maria Godelieve Bernard Baeyens, Marc Marcel Annie Maria Heyns, Paul Mertens
  • Patent number: RE36054
    Abstract: A disposable cartridge for measuring the physical properties of blood is disclosed. A waste compartment supports a platform having first and second syringe fittings. First and second syringes containing blood samples to be measured are positioned within the fittings. At least one testing station is located on the platform for subjecting blood flowing from one of the syringes to a test station, and the testing station is connected at a second end to the waste compartment. Tests on blood running through each of the blood channels may be conducted by inducing various platelet activation conditions, such as piercing a channel, or putting a platelet activating substance within a test channel. The cartridge interfaces with a test stand which will measure pressure changes within each of the test channels.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: January 19, 1999
    Assignee: XYLUM Corporation
    Inventors: Joseph Blake, Robert P. Cousineau, Mark I. Rosen, William C. Watson