Including Titration Or Ph Determination Patents (Class 436/163)
  • Patent number: 10670588
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: June 2, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10647854
    Abstract: A method of obtaining a leuco polymer, the method comprising the step of reacting a reactive leuco compound with a polymer to form the leuco polymer. The reactive leuco compound comprises at least one leuco moiety and at least one nucleophilic group. The polymer comprises at least one group capable of reacting with said nucleophilic group. The said leuco moiety has a maximum molar extinction coefficient at a wavelength in the range 400 to 750 nm of less than 1000 M?1 cm?1. Laundry care compositions comprising the leuco polymer and methods of treating textiles with such laundry care compositions.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: May 12, 2020
    Assignee: Milliken & Company
    Inventors: Sanjeev K. Dey, Haihu Qin, Gregory S. Miracle
  • Patent number: 10641662
    Abstract: The present invention relates to a method for estimating a geothermal gradient and an apparatus for estimating a geothermal gradient, and provides a method for estimating a geothermal gradient, the method comprising the steps of: calculating, at each of a plurality of points, a seismic wave crustal attenuation characteristic parameter of a seismic wave measured on the basis of the measured seismic wave information, with respect to the plurality of points; deriving an artificial neural network relational formula on the basis of the seismic wave crustal attenuation characteristic parameter; and calculating a geothermal gradient of an area of interest excluding the plurality of points on the basis of the artificial neural network relational formula, such that the geothermal gradient is estimated at a low cost by using a highly reliable method.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: May 5, 2020
    Assignee: Korea Electric Power Corporation
    Inventors: Kwan Hee Yun, Jung Tak Shim, Eun Ju Jung
  • Patent number: 10598654
    Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 24, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
  • Patent number: 10590275
    Abstract: A method of obtaining a leuco polymer, the method comprising the step of reacting a compound with a polymer to form the leuco polymer. The compound includes at least one leuco moiety and at least one electrophilic group. The polymer is comprised of co-monomers of an aryl dicarboxylate, an oxyalkyleneoxy and an oxypolyalkyleneoxy and the polymer comprises at least one moiety selected from the group consisting of hydroxy, sulfhydryl, primary amine and secondary amine. Laundry care compositions comprising the leuco polymer and methods of treating textiles with such laundry care compositions.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: March 17, 2020
    Assignee: Milliken & Company
    Inventors: Sanjeev K. Dey, Wesley A. Freund, Gregory S. Miracle
  • Patent number: 10487297
    Abstract: Provided are antimicrobial compositions that include a hydrogen peroxide generator, a peracid catalyst, a sugar acid lactone selected from among a gluconolactone, a galactonolactone, a mannonolactone, a gulonolactone and a combination thereof in an amount from about 10 wt % to about 60 wt %, an acetate, and a carboxylic acid, where the ratio between the hydrogen peroxide generator and the peracetic acid catalyst is from about 1.5:1 to about 3:1 respectively. The compositions have increased shelf life and storage stability. The antimicrobial compositions can be formulated into a disinfection solution. Also provided are methods of disinfecting a surface that include applying the disinfecting solution to a surface, resulting in the destruction of a microbe on the surface.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: November 26, 2019
    Assignee: CHEMLINK LABORATORIES, LLC
    Inventor: Ryan Giffin Moore
  • Patent number: 10317386
    Abstract: A method of measuring nitrate concentration in an aqueous sample includes mixing the aqueous sample with a water-soluble thioether chosen to reduce nitrate in the aqueous sample to nitrite in the presence of a water soluble catalyst, and a water soluble reagent system adapted to interact with nitrite to generate a color; measuring color generation, and correlating the color generation to nitrate concentration.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 11, 2019
    Assignee: HACH COMPANY
    Inventors: Darren Kent MacFarland, Angella Nicholle Greenawalt
  • Patent number: 10274454
    Abstract: To measure target component concentration in a liquid with higher accuracy without any dedicated apparatus or skill, a method is adapted to include: receiving a successive measurement value obtained by performing successive measurement of the target component concentration with use of a first measurement device immersed in the liquid; receiving a batch measurement value obtained by, with use of a second measurement device, performing batch measurement of the target component concentration in a part sampled from the liquid; and, when the batch measurement value is received, successively calculating a correlation value indicating the correlation between multiple successive measurement values and multiple batch measurement values respectively obtained in mutually corresponding multiple times of successive measurement and multiple times of batch measurement.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: April 30, 2019
    Assignees: HORIBA, LTD., HORIBA ADVANCED TECHNO, CO., LTD.
    Inventors: Akio Nakayama, Rumiko Furuya, Yuichi Ito, Akio Ishii, Yuji Gyoten, Yoshitake Ando, Hiroaki Murakami
  • Patent number: 10238766
    Abstract: The present invention relates to the field of medical diagnostics and more specifically, to identification of amniotic fluid.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: March 26, 2019
    Assignee: Common Sense Ltd.
    Inventors: Yifat Hershcovitz-Fundoiano, Vered Pardo-Yissar, Hadar Kessary Shoham
  • Patent number: 10234440
    Abstract: A method and system for testing soil includes wetting a selected soil sample to obtain a soil solution and measuring an initial pH of the soil solution. A buffer solution is then applied to the soil solution to displace alkaline anions from soil colloids of the soil solution with a displacement agent and to neutralize the alkaline anions with a neutralization agent in a buffer having a buffer pH of between 4.38 and 4.42. A resultant pH of the soil solution is then measured. A target pH for the soil sample is selected, and using mathematical relationships of the disclosure, an acidic amendment recommendation is obtained as a function of the initial pH, the resultant pH, and the target pH.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: March 19, 2019
    Inventor: Gobena Huluka
  • Patent number: 9700888
    Abstract: Disclosed is a microfluidic cartridge that can perform highly accurate lab quality DNA tests and other amplification based tests at the point of care. The cartridge may have slanted channels that angle downward from the inlet well, where the sample is deposited, to the reaction well, where the sample will flow down to and initiate the reaction. In some examples, the cartridge may be fabricated from specific materials that enhance passive flow through the channels. Additionally, the reaction wells have an access port that allows ventilation to the reaction wells that enhances the flow of the sample from the inlet to the reaction well. The access ports allow convenient access for depositing the reaction mixture into the reaction wells after the cartridge is fabricated.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: July 11, 2017
    Assignee: IPMD INC.
    Inventors: Min Lee, Seok Yong Moon, Matthew Lee, Rimma Ten, Nick Huntington, Nupur Raychaudhuri, Phillip Scott Alexander, Laurence Bianchini
  • Patent number: 9526803
    Abstract: Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 27, 2016
    Assignee: Julius-Maximilians-Universitaet Wuerzburg
    Inventors: Lorenz Meinel, Matthias Schnabelrauch, Falko Schlottig
  • Patent number: 9465035
    Abstract: A nanodiamond particle including an NV center having ODMR intensity enhanced, of which surface is modified with a functional group containing a heteroatom, is provided. This nanodiamond particle as being chemically modified can serve for a fluorescent molecular probe which can be made use of in a biological system. By tracking a rotational motion of the NV center included in this fluorescent molecular probe, structural change of a protein can be analyzed in real time. The functional group containing a heteroatom can be at least any functional group of a hydroxyl group and a hydroxyalkyl group, or a carboxyl group.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: October 11, 2016
    Assignee: Japan Science and Technology Agency
    Inventors: Masahiro Shirakawa, Shingo Sotoma, Ryuji Igarashi, Yoshie Harada
  • Patent number: 9347922
    Abstract: Method for analyzing the alkalinity conditions in aqueous liquids, comprising: sampling a known amount of the aqueous liquid and placing it in a container of known volume, measuring pH in the sampled liquid and pressure in the container, adding a known amount of CO2 to the sampled liquid, and measuring pH in the sampled liquid and the pressure in the container, and finally calculating the total alkalinity based on the values from the performed measurements. An apparatus for conducting the method is also described as well as a method for controlling chemistry of a glycol containing liquid in a system for recovery of glycol.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: May 24, 2016
    Assignee: Institutt for Energiteknikk
    Inventors: Arne Dugstad, Marion Seiersten
  • Patent number: 9182353
    Abstract: Described is a lab-on-a-chip device and a method employing a lab-on-a-chip device for determining the concentration of species present in water.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: November 10, 2015
    Assignee: Hach Company
    Inventors: Corey Alan Salzer, Vishnu Vardhanan Rajasekharan, Isabel Nicola Huenig, Rainer Froemel, Markus Lenhard, Rolf Dieter Uthemann, Aria Farjam
  • Patent number: 9040307
    Abstract: Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: May 26, 2015
    Assignee: Blood Cell Storage, Inc.
    Inventors: Michael W. Reed, Steven J. Geelhood, Robert O. Dempcy
  • Publication number: 20150111200
    Abstract: The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
    Type: Application
    Filed: September 29, 2014
    Publication date: April 23, 2015
    Inventors: J. Michael PHILLIPS, Kevin S. Bodner, Aldrich N. K. Lau, Mark F. Oldham, Donald R. Sandell, David H. Tracy, Steven J. Boege
  • Patent number: 8980636
    Abstract: A system and method for performing automated titrations. An automatic titrator utilizes control devices and sensors adapted for various chemical reactions to perform titrations and determine the content of a desired component of a solution. Batch and continuous mode titrations are possible. Titrant is added to a sample either in varying amounts or rates and a titration endpoint is observed via sensors. Control devices detect when the titration endpoint occurs and calculates the desired content. Various reactions within the solution may be suppressed in order to titrate isolated components individually.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 17, 2015
    Assignee: Ecolab USA Inc.
    Inventors: John Wilhelm Bolduc, Blake Roberts Otting, Paul R. Kraus, Robert Ryther
  • Publication number: 20150064732
    Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.
    Type: Application
    Filed: February 28, 2014
    Publication date: March 5, 2015
    Inventor: Kee Van Sin
  • Publication number: 20150064741
    Abstract: A wear-indicating metalworking fluid is provided that includes a lubricant base; and a wear-indicating agent. A method of determining wear in a metalworking fluid includes providing wear-indicating metalworking fluid that contains a lubricant base and a wear indicating agent; and observing the visual appearance of the metalworking fluid. A change in visual appearance of the metalworking fluid when compared to an unused metalworking fluid indicates wear of the metalworking fluid.
    Type: Application
    Filed: August 22, 2014
    Publication date: March 5, 2015
    Inventors: Emily J. Gibbons, Steven M. Badger, II, Leroy N. Hitchcock, Jacob F. Harkey
  • Patent number: 8969094
    Abstract: The present invention relates to a method for the validation of a non-particulate ion exchange adsorber and a kit for the validation of a non-particulate ion exchange adsorber.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: March 3, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Wolfgang Demmer, Rene Faber, Hans-Heinrich Hoerl, Axel Thiefes
  • Publication number: 20150044776
    Abstract: Provided herein are fluorescent sensor agents, and methods of use and manufacture thereof. In particular, sensor agents are provided that exhibit a detectable change in fluorescence (e.g., fluorescence intensity) upon alteration of the pH of the surrounding environment (e.g., upon moving from one pH environment to another).
    Type: Application
    Filed: March 8, 2013
    Publication date: February 12, 2015
    Applicant: PROMEGA CORPORATION
    Inventors: Mei Cong, Cesear Corona, Mark G. McDougall, Chad Zimprich
  • Patent number: 8945936
    Abstract: In one aspect of the invention, a method includes determining an amount of carbon dioxide (CO2) in dialysate flowing through a dialysis system using a CO2 sensor associated with the dialysis system, determining, using a pH sensor associated with the dialysis system, a pH level of the dialysate, and calculating a level of bicarbonate in the dialysate based at least in part on the determined amount of CO2 measured in the gas and the determined pH level of the dialysate.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: February 3, 2015
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Stephen R. Ash, Thomas A. Sullivan, David Carr, Michael James Beiriger
  • Publication number: 20150024509
    Abstract: There is provided a method and device for measuring an ion concentration of a sample. The method comprises exposing a chemical sensor to the sample to provide an electrical output signal 5 representing said ion concentration and controlling a titrator exposed to the sample to release or absorb a quantity of ions to the sample. The method may use feedback means comprising Pulse Width Modulation control to drive the titrator such that the sample maintains a stable ion concentration.
    Type: Application
    Filed: March 6, 2012
    Publication date: January 22, 2015
    Applicant: DNA ELECTRONICS LTD.
    Inventors: Christofer Toumazou, Yan Liu
  • Publication number: 20150024508
    Abstract: A pH sensing apparatus includes an ion-sensing cell that includes a first half-cell including a first Ion-Sensitive Field Effect Transistor (ISFET) exposed to a surrounding solution; and a second reference half-cell exposed to the surrounding solution. The pH sensing apparatus further includes a pressure sensitivity compensation loop including a Non Ion-Sensitive Field Effect Transistor (NISFET). The pH sensing apparatus is configured to compensate for at least one of pressure and physical stresses using signals from the ion-sensing cell and feedback from the pressure sensitivity compensation loop. The pH sensing cell further includes a processing device configured to calculate a final pH reading compensated to minimize the at least one of pressure and physical stresses.
    Type: Application
    Filed: July 22, 2013
    Publication date: January 22, 2015
    Inventors: Donald Horkheimer, David S. Willits
  • Publication number: 20150011010
    Abstract: The invention is related to an optode for determining chemical parameters of a sample wherein the optode consists of a polymer matrix consisting of sulfonated polyether ether ketone (SPEEK) in which a sensor dye is immobilized or more than one sensor dye is immobilized, wherein at least one of the immobilized sensor dyes is pH-sensitive. In addition, the present invention also concerns a method for determining the pH of a sample in which the invention-related optode is used.
    Type: Application
    Filed: January 18, 2013
    Publication date: January 8, 2015
    Inventors: Doerte Steinbrueck, Elmar Schmaelzlin, Hans-Gerd Loehmannsroeben
  • Patent number: 8921113
    Abstract: A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 30, 2014
    Assignee: Dionex Corporation
    Inventors: Shanhua Lin, Christopher A. Pohl
  • Publication number: 20140356974
    Abstract: A pH detectable coating. The pH detectable coating includes a pH insensitive fluorescent dye and a pH sensitive fluorescent dye. The pH insensitive fluorescent dye and the pH sensitive fluorescent dye are attached to a surface. The ratio of the fluorescent intensity of the pH insensitive fluorescent dye to the fluorescent intensity of the pH sensitive fluorescent dye varies according to the pH of an environment into which the surface is placed.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 4, 2014
    Inventors: Wen-Jing Hu, Liping Tang
  • Patent number: 8900875
    Abstract: A method for assessing a corrosion inhibitor in a coolant, comprises providing a test kit comprising a first chamber containing an acid buffer and a solvent immiscible therein and a second chamber containing an indicator, the second chamber being in fluid communication with the first chamber and being configured such that retraction of the second chamber draws fluid into the first chamber and advancement forces fluid into the second chamber; drawing a coolant sample into the first chamber; contacting the coolant sample with the acid buffer and solvent in the first chamber and extracting the corrosion inhibitor into the solvent; allowing the solvent and buffer to separate in the first chamber; forcing a portion of the separated solvent into the second chamber; contacting the separated solvent with the indicator in the second chamber, and obtaining a visual indication of the presence of corrosion inhibitor in the coolant sample.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: December 2, 2014
    Assignee: Shell Oil Company
    Inventors: Abraham Robert De Kraker, Liliana Minevski, Tze Lee Phang
  • Publication number: 20140349326
    Abstract: Apparatus and methods are provided for analyzing a medical condition of a user. The apparatus may include a user interface configured to receive user identification information inputted by the user, an analyzer, and a processor all disposed within a common housing. The analyzer is configured to receive a biological specimen from the user and to analyze the biological specimen to generate analysis information. The processor is configured to store and forward the analysis information and to receive prescription information. The apparatus may include a communication unit configured to transmit the user identification information and the analysis information to a doctor at a remote location for review and to receive the prescription information from the doctor. The apparatus then may dispense the prescribed medication or print a medication prescription.
    Type: Application
    Filed: February 6, 2013
    Publication date: November 27, 2014
    Inventor: Michael INGBER
  • Publication number: 20140329331
    Abstract: The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid pH-activated ratiometric NIR probe because it is able to be activated in an acidic pH and is usable in an aqueous environment.
    Type: Application
    Filed: January 7, 2013
    Publication date: November 6, 2014
    Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
    Inventors: Juyoung Yoon, Guo Zhiqian
  • Publication number: 20140323322
    Abstract: A chemical sensor comprising: a hydrogel layer, comprising one or more molecular recognition agents and a 2DPC self-assembling array; and a mirror layer. A method for analyzing a sample or bodily fluid, comprising: obtaining a sample or bodily fluid; placing an amount of the sample or bodily fluid onto a chemical sensor, comprising: a hydrogel layer, comprising a molecular recognition agent and a 2DPC self-assembling array; a tethering hydrogel layer; a mirror layer; and a membrane filter layer, allowing the bodily fluid to interact with the hydrogel layer; and allowing ambient or artificial light to pass through the hydrogel layer onto the mirror layer and observing a change in diffraction versus a control.
    Type: Application
    Filed: October 4, 2012
    Publication date: October 30, 2014
    Inventor: Sanford A. Asher
  • Patent number: 8859288
    Abstract: Methods to produce pH-sensitive microparticles that have an active agent dispersed in a polymer matrix have certain advantages over microcapsules with an active agent encapsulated in an interior compartment/core inside of a polymer wall. The current invention relates to pH-sensitive microparticles that have a corrosion-detecting or corrosion-inhibiting active agent or active agents dispersed within a polymer matrix of the microparticles. The pH-sensitive microparticles can be used in various coating compositions on metal objects for corrosion detecting and/or inhibiting.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: October 14, 2014
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Wenyan Li, Jerry W. Buhrow, Scott T. Jolley, Luz M. Calle
  • Publication number: 20140302615
    Abstract: Provided is a cathode active material containing a Ni-based lithium mixed transition metal oxide. More specifically, the cathode active material comprises the lithium mixed transition metal oxide having a composition represented by Formula I of LixMyO2 wherein M, x and y are as defined in the specification, which is prepared by a solid-state reaction of Li2CO3 with a mixed transition metal precursor under an oxygen-deficient atmosphere, and has a Li2CO3 content of less than 0.07% by weight of the cathode active material as determined by pH titration. The cathode active material in accordance with the present invention and substantially free of water-soluble bases such as lithium carbonates and lithium sulfates and therefore has excellent high-temperature and storage stabilities and a stable crystal structure.
    Type: Application
    Filed: June 18, 2014
    Publication date: October 9, 2014
    Applicant: LG Chem, Ltd.
    Inventors: Hong-Kyu Park, Sun sik Shin, Sin young Park, Ho suk Shin, Jens M. Paulsen
  • Patent number: 8852882
    Abstract: A FRET donor-acceptor pair for use as a biosensor, comprising at least two fluorescence proteins, wherein at least one fluorescence protein is stable with respect to a parameter to be detected by the biosensor and at least one fluorescence protein is unstable with respect to the parameter to be detected by the biosensor.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: October 7, 2014
    Assignee: Evocatal GmbH
    Inventors: Karl Erich Jaeger, Thomas Drepper, Stephan Endres, Janko Potzkei, Achim Heck, Franco Circolone
  • SK
    Publication number: 20140287517
    Abstract: This invention relates to methods and means for performing pool and other water and liquid testing. Some embodiments of the methods and means of the invention also incorporate additional functionality including, but not limited to communication, sensing, display and data processing elements. Various embodiments of the methods and means of the invention may be performed by and/or implemented in hardware, in software, by one or more entities, and/or by some combination of hardware, software and/or one or more entities.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Inventor: Alfred M. Haas
  • Publication number: 20140273265
    Abstract: A microfluidic cartridge for assaying an analyte comprises one or more test channels, each having a lumen; one or more reference solution channels in fluid communication with the test channels; one or more sample channels in fluid communication with the test channels; one or more sensors at least partially exposed in the lumen of the test channels; and a processor coupled to the one or more sensors for measuring properties of the analyte to determine at least one of an identity, concentration, dose, and dosage of the analyte.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: Joseph FEINGOLD, Hector Luis Penagos-Vargas
  • Publication number: 20140256055
    Abstract: A method for detecting hydrocarbons is described. The method includes performing a remote sensing survey of a survey location to identify a target location. Then, an underwater vehicle (UV) is deployed into a body of water and directed to the target location. The UV collects measurement data within the body of water at the target location, which is then analyzed to determine whether hydrocarbons are present at the target location.
    Type: Application
    Filed: November 9, 2012
    Publication date: September 11, 2014
    Inventors: Robert J. Pottorf, Leonard J. Srnka, William Bond, Sebastien L. Dreyfus, Michael Lawson, William P. Meurer, Daniel P. Cherney, Steven R. May, William G. Powell, Christoper J. Vandewater, Mehmet D. Ertas, Sumathy Raman, Aaron B. Regberg, A. Lucie N'Guessan, Amelia C. Robinson, Kurt W. Rudolph
  • Patent number: 8828728
    Abstract: An aquatic environment monitoring system and method that includes correction for adverse conditions in the monitoring system involving the development of confidence levels for certain conditions in the monitoring system using stored information related to the aquatic environment and/or the monitoring system. Corrections to adverse conditions may be made by the environment monitoring system automatically by the monitoring system and manually via communications to a user of the system.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: September 9, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Publication number: 20140248646
    Abstract: A fluorophore and methods of detecting cations and hydrophobic environments using the fluorophore are disclosed. The fluorophore includes an imidazo[1,5-a]pyridinium ion core and has the formula where R1, R2, R3 and X? are as defined in the specification, and n is an integer from 1 to 4.
    Type: Application
    Filed: March 4, 2013
    Publication date: September 4, 2014
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Indiana University Research and Technology Corporation
  • Publication number: 20140220699
    Abstract: A pH-buffer measurement system that has at least one source for modifying the pH of a fluid entering the system, the source selected from an acid source and a base source. The acid source adds an acid equivalent to provide an acid reacted fluid and the base source adds a base equivalent to provide a base reacted fluid. The source is in fluid communication with a flow path and a component for determining a fluid characteristic of the acid reacted fluid or the base reacted fluid. The fluid characteristic that is measured is any one of a gas phase pressure, an electrical conductivity, or thermal conductivity.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 7, 2014
    Applicant: MEDTRONIC, INC.
    Inventors: Bryant J. Pudil, Thomas E. Meyer, David B. Lura, Martin T. Gerber
  • Patent number: 8785207
    Abstract: The present invention relates generally a method and apparatus for measuring multiple parameters in-situ in a sample collected from an environmental system via a single device. In one embodiment, the method includes collecting the sample from said environmental system via the single device, measuring a first parameter of the sample in-situ via the single device, adding a reagent tot the sample within the single device to create a reagent infused sample and measuring a second parameter of the sample in-situ via the single device using the reagent infused sample.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: July 22, 2014
    Assignee: SRI International
    Inventors: Ryan J. Bell, R. Timothy Short, Strawn K. Toler, Robert H. Byrne
  • Publication number: 20140199775
    Abstract: A subsea monitoring device comprises a metal part (12) disposed in a polymeric sheath (11,14), and means (10) for providing a sensible indication of pH at an interface between the part and the sheath. The part may be the metal shell of a connector. When a cable (13) extends from the connector, adjacent the connector the cable would be covered by the polymeric sheath. The said means (10) may comprise a chemical indicator and the sheath is preferably sufficiently translucent to allow visual observation of the indicator. The chemical indicator may comprise phenolphthalein.
    Type: Application
    Filed: May 14, 2013
    Publication date: July 17, 2014
    Applicant: AKER SUBSEA LIMITED
    Inventor: Philip Michael Bagley
  • Publication number: 20140186962
    Abstract: The present invention relates to an optical H+-sensor, comprising an H+-indicator material, wherein the H+-indicator material is present between a support material and a H+-permeable layered structure, the layered structure comprising an H+-permeable hydrophilic layer and an H+-permeable cation exchange layer. Further, the invention relates to a method for determining the H+-concentration, e.g. expressed as pH, in a product or sample thereof, the method comprising contacting the product or sample with an optical H+-sensor according to the invention, measuring an optical property of the indicator material, and determining the H+-concentration of the product or sample based on said optical property.
    Type: Application
    Filed: March 28, 2012
    Publication date: July 3, 2014
    Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO
    Inventors: Jacobus Johannes Frederik van Veen, Cornelis Gerardus Josephus Koopal
  • Patent number: 8753896
    Abstract: A method of monitoring a surfactant in a microelectronic process is disclosed. Specifically, the monitoring of a surfactant occurs by studying the fluorescence or electromagnetic emission of a sample collected from a microelectronic process.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: June 17, 2014
    Assignee: Nalco Company
    Inventors: Brian V. Jenkins, John E. Hoots, Amy M. Tseng
  • Patent number: 8753586
    Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: June 17, 2014
    Assignee: Waters Technologies Corporation
    Inventors: David P. Prentice, Russell L. Keene, Stanilaw Koziol, Joseph D. Michienzi, Paul E. Linderson
  • Publication number: 20140154815
    Abstract: A method of changing the fluorescent properties of a complex, the method comprising: providing a first complex comprising a multidentate ligand that is coordinated to a lanthanide ion, wherein the lanthanide is selected from europium and terbium and the multidentate ligand has at least one optionally substituted phthalimide group coordinated to the lanthanide ion, contacting the complex with an aqueous liquid medium under appropriate conditions, such that at least one phthalimide group is hydrolysed to a phthalamate group, to form a second complex. Complexes and compounds are also disclosed.
    Type: Application
    Filed: April 13, 2012
    Publication date: June 5, 2014
    Applicant: LONDON METROPOLITAN UNIVERSITY
    Inventors: Sim-Wan Annie Bligh, Nicholas Paul Chatterton, Nicholas James Wardle, Jason Lee Sarris, Gaoyun Chen
  • Publication number: 20140147923
    Abstract: Methods and systems for testing fluid samples include a diffused air flotation (DAF) system and a jar. The jar includes a diffuser for injecting the diffused air into the jar and a tap for drawing a fluid out of the jar.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 29, 2014
    Applicant: BAKER HUGHES INCORPORATED
    Inventors: Stephen J. Wiacek, Bingbing Guo
  • Patent number: 8728758
    Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: May 20, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Reuven Tirosh, Fernando Patolsky, Hagit Peretz-Soroka
  • Patent number: 8709815
    Abstract: Methods and devices are disclosed providing techniques for measuring the amount of biodiesel in a fuel sample. The methods may be used in the field without the use of laboratory equipment. The biodiesel in the sample is converted to the corresponding free acid which can be isolated and quantified to provide information regarding the amount of biodiesel in the original sample.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: April 29, 2014
    Assignee: Dexsil Corporation
    Inventors: Theodore B. Lynn, Lawrence M. Sacramone