Including Reagent Preparation Patents (Class 436/166)
  • Patent number: 10834959
    Abstract: The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of nicotine and may have other benefits, e.g., lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of the Nicotiana species, wherein the protein composition is characterized by relatively low nicotine content.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: November 17, 2020
    Assignee: R.J. Reynolds Tobacco Company
    Inventors: Kyle Ford, John-Paul Mua, Nicholas Partain, Joshua D. Morton, Barry Bratcher
  • Patent number: 10597352
    Abstract: Stable formulations of alkyl benzidine compounds and methods of making and using same. To prepare a stable formulation, a short chain diol having fewer than six carbon atoms and an alkyl benzidine compound are combined together in solution at low pH and the solution is heated with moderate heat in the range of about 50° C. to 80° C. The stable formulation may contain dimers and/or trimers of the short chain diol. The stable formulation can be used to detect total chlorine in aqueous solution, to detect total chlorine in dialysis water, or as a colorimetric substrate in enzyme-linked immunosorbent assays.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: March 24, 2020
    Assignee: OneStep Technologies Inc.
    Inventor: Hao Zhang
  • Patent number: 10416119
    Abstract: A measurement method of a specimen liquid includes preparing a sensor chip comprising a reference SAW element and a detection SAW element have a relationship of an expression: t·V<L, where t, V and L denote is as defined in the specification; causing the specimen liquid to flow in order from either one of the reference SAW element and the detection SAW element: calculating a change with time of a phase difference ?? between a phase ?ref in the reference SAW element and a phase ?test in the detection SAW element; and measuring a detection target from a starting point which is a point in time at an extreme value or later in the change with time of the phase difference ??.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: September 17, 2019
    Assignee: KYOCERA CORPORATION
    Inventor: Hiroshi Katta
  • Patent number: 10392500
    Abstract: Compositions include an aqueous solution of an organic dye of molecular weight in the range of about 300 to about 1,000 and a density-enhancing material. An amount of the density-enhancing material in the aqueous solution is sufficient to achieve a density of about 1.0 to about 1.3 g/mL. The composition has a viscosity of about 3.5 to about 5.0 centipoise. The compositions are useful in assessing the adequacy of a liquid handling mixing device to mix a reaction mixture.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: August 27, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jason Snyder, Richard H. Carter, Jr., Patricia Nichols, William D. Dunfee
  • Patent number: 10215702
    Abstract: There is provided a method of preparing a surface enhanced Raman spectroscopy (SERS) particle comprising the step of encapsulating a plurality of Raman molecules on the surface of a metallic core with a biocompatible protective shell at an elevated temperature selected to decrease the encapsulation time by more than one-fold relative to an encapsulation performed at 20° C.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: February 26, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Shuhua Liu, Kwok Wei Shah, Michelle Low, Zhi Wei Seh, Ming-Yong Han, Kaustabh Kumar Maiti, Kiat Seng Jason Soh, Dinish Unnimadhava Kurup Soudamini Amma, Malini Olivo, Young-Tae Chang
  • Patent number: 10119918
    Abstract: Compositions are provided comprising: 1) a solid metal oxide support having surface hydroxyl groups; 2) a silyl-containing compound bound to the solid metal oxide support through a silanol bond with the surface hydroxyl groups; and 3) a bis(glyoxime)-transition metal complex bound to the solid metal oxide support. These compositions can be used to make a colorimetric relative humidity-indicating sensor. A method of adjusting the colorimetric response of a moisture-indicating composition and a method of detecting moisture are also provided.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: November 6, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Myungchan Kang, Evan Koon Lun Yuuji Hajime
  • Patent number: 9933369
    Abstract: A reagent includes a coloring agent allowing a measured solution to develop a color transmitting a region component light for a dissolved-substance concentration measurement selected from three region component lights of red, green, and blue obtained by transmitting a light including a visible light region to the measured solution colored by addition of the reagent to the sample, and dividing a light of the visible light region of a transmitted light thereof into roughly three portions. Based on the transmitted light from the measured solution with the coloring agent added, an absorbance of the region component light for the dissolved-substance concentration measurement, and an absorbance A3 of another region component light resulted only from the coloring agent are calculated. Whether or not the reagent in a necessary quantity is added to the sample can be judged by comparing the absorbance A3 and a standard absorbance A0.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: April 3, 2018
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventors: Yoshitaka Kishine, Toshikazu Takahashi, Junichi Takahashi
  • Patent number: 9902920
    Abstract: The present invention relates to the field of perfumery. More particularly, it concerns polymers derived from siloxane derivatives and comprising at least one ?-thio carbonyl moiety capable of liberating an active molecule such as, for example, an ?,?-unsaturated ketone or aldehyde. The present invention concerns also the use of polymers in perfumery as part of a perfuming or malodor counteracting composition as well as the perfuming compositions or perfumed articles comprising the invention's compounds.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: February 27, 2018
    Assignee: Firmenich SA
    Inventors: Yongtao Wu, Damien Berthier
  • Patent number: 9846127
    Abstract: Disclosed are a colorimetric detection sensor and colorimetric detection method of a cyanide anion (CN?) by etching of gold nanorods. The colorimetric detection sensor and colorimetric detection method use label-free nanorods having no modifier attached to a surface of gold nanorods (AuNRs), wherein the aspect ratio of nanorods, pH condition and/or amount of a surfactant are controlled to carry out selective etching and to cause a change in color only by CN? so that CN? contained or dissolved in poison, water-contaminated environmental samples and legal evidence samples may be detected with ease, and show excellent selectivity, sensitivity and quantitative analyzability to CN? to provide high usefulness.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: December 19, 2017
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kangbong Lee, Yunsik Nam, Sujin Lee, Yeonhee Lee, Inhwan Oh
  • Patent number: 9771321
    Abstract: A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in structure to Formula I, below, where the various substituents are defined within, and reacts chemoselectively with one or two of four Lys-15 ?-amino groups within the transthyretin tetramer. The crystal structure confirms the binding orientation of the compound substructure and the conjugating amide bond. A covalent transthyretin kinetic stabilizer exhibits superior amyloid inhibition potency, compared to a non-covalent counterpart, and inhibits cytotoxicity associated with amyloidogenesis.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: September 26, 2017
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Jeffery W Kelly, Sungwook Choi
  • Patent number: 9667035
    Abstract: The present disclosure provides a preparation method of a polymer film laser. Polymer materials are dissolved in an organic solvent, a polymer solution is spin-coated on a substrate with or without a grating structure, and a homogeneous polymer thin film is formed. For the substrate without the grating structure, an interference pattern of an ultraviolet laser is used to interact with a thin polymer film, and one-dimensional or multi periods grating structures with multi directions are formed. The substrate with the thin polymer film is immersed in a hydrochloric acid solution or water and the polymer film with the grating structure peels off the substrate to obtain the polymer film laser. A pump beam is used to excite the polymer film to generate fluorescence, which is reflected and gained by the grating to obtain laser outputs.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: May 30, 2017
    Assignee: Beijing University of Technology
    Inventors: Tianrui Zhai, Songtao Li, Li Chen, Li Wang, Xinping Zhang
  • Patent number: 9440925
    Abstract: The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: September 13, 2016
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Aimei Chen, Hee Chol Kang
  • Patent number: 9435745
    Abstract: A method of measuring the relative rates of release of a target metal ion from two or more samples includes: (i) providing at least two aliquots of a solution including an indicator, the indicator having a color; (ii) dispersing a sample into each aliquot; and (iii) during step (ii), monitoring the color of the indicator in situ to determine the rates of release of the target metal ions from the samples relative to one another. Each sample includes at least one source of the target metal ion. The indicator contains zincon. The samples are oral care compositions selected from a toothpaste, a tooth gel, and a tooth powder. The target metal ion is selected from the stannous and zinc (II).
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: September 6, 2016
    Assignee: Colgate-Palmolive Company
    Inventors: Stanislav Jaracz, Ravi Subramanyam, Michael Prencipe
  • Patent number: 9354144
    Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: May 31, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Alireza Ebrahim, Christopher Spates, Karl De Vore
  • Patent number: 9279759
    Abstract: The present invention is directed to self-assembled nanoparticle arrays, methods of making the nanoparticle arrays, and methods of using the nanoparticle arrays in spectroscopic methods for detecting targets of interest. The present invention is also directed to a fabrication method for surface-enhanced Raman scattering (SERS) substrates that possess a unique combination of three highly desirable attributes: (a) the SERS substrates can be tuned to match the laser wavelength of operation and maximize the enhancement factor for the particular Raman instrument and analyte in use; (b) the SERS substrates have a highly reproducible enhancement factor over macroscopic sampling areas; and (c) the fabrication method is achieved without resorting to expensive, slow nano-lithography tools.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: March 8, 2016
    Assignee: University of Maryland, College Park
    Inventors: Woonjoo Lee, Seung Yong Lee, Oded Rabin, Robert M. Briber, Xin Zhang
  • Patent number: 9145361
    Abstract: The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: September 29, 2015
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kyle Gee, Aimei Chen, Hee Chol Kang
  • Patent number: 9097680
    Abstract: A water testing system having a water sample container that is adapted to retain the water sample, a color indicator container that is adapted to dispense a color indicator, and a titration reagent container that is adapted to dispense a titration reagent. A method for determining the concentration of sodium dimethyldithiocarbamate in a water sample comprising providing a water testing system having a water sample container that is adapted to retain the water sample, a color indicator container that is adapted to dispense a color indicator, and a titration reagent container that is adapted to dispense a titration reagent. The preferred method also comprises placing the water sample in the water sample container, adding the color indicator to the water sample, adding the titration reagent to the water sample, and determining the concentration of sodium dimethyldithiocarbamate in the water sample.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: August 4, 2015
    Inventor: Randy Fowler
  • Patent number: 9040305
    Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: May 26, 2015
    Assignee: Singulex, Inc.
    Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard A. Livingston, Douglas Held
  • Publication number: 20150140678
    Abstract: Disclosed herein is a method for stabilizing quantum dots. The method comprises introducing a first monomer into a mini emulsion system. The first monomer is a crosslinking polymer. A second monomer is added to the system so as to stabilize the quantum dots. Also disclosed is a method of increasing the brightness of the quantum dots by adding a redox initiator system at a low temperature to reduce fluorescence quenching.
    Type: Application
    Filed: April 26, 2013
    Publication date: May 21, 2015
    Inventor: Bo Qi
  • Publication number: 20150140679
    Abstract: Compositions include an aqueous solution of an organic dye of molecular weight in the range of about 300 to about 1,000 and a density-enhancing material. An amount of the density-enhancing material in the aqueous solution is sufficient to achieve a density of about 1.0 to about 1.3 g/mL. The composition has a viscosity of about 3.5 to about 5.0 centipoise. The compositions are useful in assessing the adequacy of a liquid handling mixing device to mix a reaction mixture.
    Type: Application
    Filed: June 25, 2013
    Publication date: May 21, 2015
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jason Snyder, Richard H. Carter, JR., Patricia Nichols, William D. Dunfee
  • Patent number: 9034652
    Abstract: Colloidal formulation for staining proteins and methods of their use are provided.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: May 19, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Christopher Belisle, Lee Olech, Thomas Berkelman, Praveena Garimella
  • Patent number: 9012234
    Abstract: A mobile water analyzing system for determining an analyte in a water sample includes a basic unit and a test element configured to be inserted into the basic unit. The test element includes a sample line with an inlet opening configured to receive the water sample, a measuring section forming a measuring track and configured to allow the determination of an analyte, a pump opening, and a key reagent disposed inside the sample line. The basic unit includes a test element receptacle configured to hold the inserted test element, an analyzer with an analyzer measuring track formed by the measuring section, and a pump actuator cooperatively connected with the pump opening.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: April 21, 2015
    Assignee: Hach Lange GmbH
    Inventors: Ulrich Lundgreen, Aria Farjam, Rolf Uthemann, Andreas Mitreiter, Isabel Huenig, Markus Lenhard, Rainer Froemel, Hans-Joachim Kumpch
  • Patent number: 8999725
    Abstract: In one embodiment of the present application, a stimulus-responsive gel is disclosed with optical characteristic molecule introduced therein that is capable of easily and securely converting a volume change responding to external stimulus to optical data being easy to handle in the construction of sensor system; an external stimulus measuring apparatus making use of the same; and a method of measuring external stimulus therewith.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: April 7, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Takashi Miyata, Tadashi Uragami, Kaori Okawa
  • Patent number: 8999264
    Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 7, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia
  • Publication number: 20150093771
    Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.
    Type: Application
    Filed: December 2, 2014
    Publication date: April 2, 2015
    Inventors: Patrick Griss, Rainer Jaeggi, Goran Savatic, Vuk Siljegovic
  • Patent number: 8987001
    Abstract: The present invention relates to an oxygen indicator in which the presence or absence of oxygen is made visible by a color change, and to the use of such oxygen indicator for monitoring parenteral and enteral dosage forms.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: March 24, 2015
    Assignee: B. Braun Melsungen AG
    Inventors: Volker Krueger, Rolf Beck
  • Patent number: 8961879
    Abstract: The invention relates to curable compositions which are prepared from polyol components containing one or more polyols and isocyanate components containing one or more isocyanates, which compositions contain at least one indicator having at least one quinonoid group, which indicator signifies the degree of curing by a change of color. The invention also relates to a method for indicating the progress of curing in such curable compositions.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: February 24, 2015
    Assignee: Mankiewicz Gebr. & Co. GmbH & Co. KG
    Inventors: Guenther John, Stefanie Ehmke (nee Behrens Brammertz)
  • Patent number: 8956876
    Abstract: There is provided a method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution with high sensitivity. A method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution, including the steps of 1) immobilizing a fluorescent probe molecule showing a fluorescence response specific to 8-oxo 2?-deoxyguanosine on surfaces of fine particles via a spacer unit and bringing the sample solution into contact with the fine particles, and 2) measuring a physical property of the fine particles before and after the contact with the sample solution to determine a change in the physical property.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 17, 2015
    Assignee: TAS Project Co. Ltd
    Inventors: Shigeki Sasaki, Osamu Nakagawa, Zhichun Li, Atsushi Takaki, Sachiyo Saitoh
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Patent number: 8940542
    Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 27, 2015
    Assignee: Lighthouse Medical Limited
    Inventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8935007
    Abstract: An analyte testing device is provided for use with a mobile processing device having a camera with a lens, a processor for processing an image captured by the lens. The analyte testing device comprises a casing and a test strip positioner. The test strip positioner positions an analyte containing test strip adjacent to the camera lens to permit the camera to capture an image of the analyte containing test strip. A light source is disposed within the casing. The light source is positioned within the casing to illuminate the analyte containing test strip to facilitate the capture of the image of the test strip. Software is contained within the mobile processing device for performing a quantitative analysis of at least one analyte from the captured image, and providing an output of the results of the quantitative analysis.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: January 13, 2015
    Assignee: 4a medicom GmbH
    Inventors: Hans G. Kloepfer, Thomas Kloepfer, Jason Heim, Reinhard Hafellner
  • Patent number: 8927299
    Abstract: There is disclosed apparatus and a system for effecting testing on a sample, such as for medical testing. The apparatus includes a sample chip (30) provided with at least two chambers (48, 50) within which analyte and a sample to be tested can be located, one chamber being a mixing chamber (48) and the other a detection chamber (50), the latter being provided with a sensor or means to enable sensing of one or more parameters pertaining to the sample. A detector unit (70, 170) includes a slot (76) for holding a sample carrier (30), drive means (94) for moving parts of a sample from the mixing chamber (48) to the detection chamber (50), such as by electromagnetic force, sensing means (60) for sensing the one or more parameters, a diagnostic unit (84) for analyzing the sensed parameters and a display unit (72) for displaying the results of the test to a user. The test unit (70, 170) is preferably handheld, which the sample carrier (30) is preferably in the form of a disposable chip.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: January 6, 2015
    Assignee: The Secretary of State for Innovation, Universities and Skills of Her Majesty's Britannic Government
    Inventor: Robert Andrew Porter
  • Patent number: 8920857
    Abstract: A system and method for a beverage container configured to test for a contaminated beverage in the beverage container comprises a base of the beverage container, an upper portion of the beverage container, and a sidewall with an inner surface and an outer surface that extends from the base to the upper portion, and a testing material. A portion of the beverage container is the testing material configured to visibly react when the portion of the beverage container is contacted with the contaminated beverage.
    Type: Grant
    Filed: August 7, 2011
    Date of Patent: December 30, 2014
    Inventors: Michael T. Abramson, John C. MacDonald
  • Patent number: 8920746
    Abstract: The present invention relates to devices and systems for detecting the existence of oral conditions.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 30, 2014
    Assignee: Colgate-Palmolive Company
    Inventors: Douglas Hohlbein, Elizabeth Gittens, Harsh M. Trivedi, Sharon Kennedy, Madhusudan Patel, Deborah Peru
  • Patent number: 8900875
    Abstract: A method for assessing a corrosion inhibitor in a coolant, comprises providing a test kit comprising a first chamber containing an acid buffer and a solvent immiscible therein and a second chamber containing an indicator, the second chamber being in fluid communication with the first chamber and being configured such that retraction of the second chamber draws fluid into the first chamber and advancement forces fluid into the second chamber; drawing a coolant sample into the first chamber; contacting the coolant sample with the acid buffer and solvent in the first chamber and extracting the corrosion inhibitor into the solvent; allowing the solvent and buffer to separate in the first chamber; forcing a portion of the separated solvent into the second chamber; contacting the separated solvent with the indicator in the second chamber, and obtaining a visual indication of the presence of corrosion inhibitor in the coolant sample.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: December 2, 2014
    Assignee: Shell Oil Company
    Inventors: Abraham Robert De Kraker, Liliana Minevski, Tze Lee Phang
  • Patent number: 8889421
    Abstract: The present invention relates generally to a kit and method for the colorimetric detection of precursors used in the assembly of homemade explosives (HMEs). More specifically, the present invention relates to a bulk HME precursor detection kit and methods of using a kit that is capable of bulk detection of HME precursors, such as urea nitrate, ammonium nitrate and potassium chlorate.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: November 18, 2014
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Wayne Ouellette, John H. Wilkinson, James N. Thomasson, III, Frederick S. Heim, Herbert Mitchell, Robert G. Best
  • Patent number: 8834795
    Abstract: An optochemical sensor element suitable for sensing an analyte comprises a polymeric material in which at least a portion of the polymer material is solvent crazed to provide a multiplicity of pores of controlled nanometer size, and an indicator dye impregnated into the pores, in which optochemical sensor element the indicator dye is a long-decay photoluminescent dye selected from the group consisting of: phosphorescent platinum(II)—and palladium (II) complexes of porphyrin dyes such as octaethylporphine, coproporphyrin, octaethylporphine-ketone, benzoporphine, tetra (pentafluorophenyl) porphine, chlorin e6; fluorescent complexes of ruthenium (II), osmium(II), iridium(III) and europium (III); or derivatives or close analogs of these dyes. The sensor element in the presence of the analyte alters a photoluminescence parameter thus allowing sensing and/or quantification of the analyte.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: September 16, 2014
    Assignee: Luxcel Biosciences Limited
    Inventors: Olga Vladimirovna Arzhakova, Nikolai Filippovich Bakeev, Aleksandr L'vovich Volynskii, Alla Anatol'evna Dolgova, Larisa Mikhailovna Yarysheva, Ponomarev Gelii Vasilievich
  • Patent number: 8828738
    Abstract: The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with non-human IgM or fragments thereof by dissolving into said sample a dry reagent to yield a non-human IgM concentration of at least about 20 ?g/mL or equivalent fragment concentration; and (b) performing an electrochemical immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG or fragments thereof in addition to the IgM of fragments thereof.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: September 9, 2014
    Assignee: Abbott Point of Care Inc.
    Inventors: John Lewis Emerson Campbell, John Emegbero Omakor
  • Patent number: 8828734
    Abstract: Provided are a nitric oxide detection element capable of detecting NO gas contained in a mixed gas at a high speed even when the amount thereof is a super trace amount of ten and several parts per billion; and a process for producing the element. In a nitric oxide detection element having a substrate 12 and a sensing film 11 formed on a surface of the substrate, the sensing film is composed of nitric oxide sensing particles and a polymer adhesive. The nitric oxide sensing particles are produced by adsorbing a dye having a porphyrin skeleton and having, as a central metal, divalent cobalt onto surfaces of inorganic particles.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: September 9, 2014
    Assignees: Panasonic Healthcare Co., Ltd., National University Corporation Ehime University
    Inventors: Kouichi Hiranaka, Toyofumi Nagamatsu, Yoshihiko Sadaoka, Yoshiteru Itagaki
  • Patent number: 8815606
    Abstract: A thin-layer chromatography method for detection and identification of common military and peroxide explosives in samples includes the steps of provide a reverse-phase thin-layer chromatography plate; prepare the plate by marking spots on which to deposit the samples by touching the plate with a marker; spot one micro liter of a first standard onto one of the spots, spot one micro liter of a second standard onto another of the spots, and spot samples onto other of spots producing a spotted plate; add eluent to a developing chamber; add the spotted plate to the developing chamber; remove the spotted plate from the developing chamber producing a developed plate; place the developed plate in an ultraviolet light box; add a visualization agent to a dip tank; dip the developed plate in the dip tank and remove the developed plate quickly; and detect explosives by viewing said developed plate.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: August 26, 2014
    Assignee: Lawrence Livermore National Security, LLC.
    Inventors: Philip F. Pagoria, Alexander R. Mitchell, Richard E. Whipple, M. Leslie Carman
  • Patent number: 8815608
    Abstract: Curable compositions are prepared from polyol components containing one or more polyols and isocyanate components containing one or more isocyanates, which compositions contain at least one indicator having at least one quinonoid group, which indicator signifies the degree of curing by a change of color. A method is also provided for indicating the progress of curing in such curable compositions.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: August 26, 2014
    Assignee: Mankiewicz Gebr. & Co. GmbH & Co. KG
    Inventors: Guenther John, Stefanie Ehmke
  • Patent number: 8815603
    Abstract: A chemochromic indicator is provided that includes a hypergolic fuel sensing chemochromic pigment that change from a first color to a second color in the presence of a hypergolic fuel. In a first embodiment, a chemochromic indicator is provided for detecting the presence of a hypergolic fuel such that the irreversible hypergolic fuel sensing chemochromic pigment includes potassium tetrachloroaurate (KAuCl4). There are several types of chemochromic indicators, for example, the article used to form the chemochromic indicators include, but are not limited to, wipe materials, silicone/TEFLON tape, manufactured parts, fabrics, extruded parts, and paints.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: August 26, 2014
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Luke B. Roberson, Robert W. DeVor, Janine E. Captain, Edgardo Santiago-Maldonado
  • Patent number: 8809061
    Abstract: A living body phantom according to the present invention, which is used as a testing sample in a prepared slide in estimating the performance of a microscope objective lens with the image of the testing sample in the prepared slide acquired by an imaging means via the microscope objective lens and with optical characteristics obtained from the image of the testing sample, includes a non-gel-like solution at least including: a solvent which at least includes water, a refractive index adjustment agent, and a scattering body or which at least includes a refractive index adjustment agent and a scattering body; and a thickener.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: August 19, 2014
    Assignee: Olympus Corporation
    Inventors: Asuka Mukai, Koji Yoshida
  • Patent number: 8790930
    Abstract: A chemical indicator having a particulate inorganic substrate, and at least one reactive dye or ink coated on and/or impregnated within the particulate inorganic substrate. Coating and/or impregnating at least one reactive dye or ink on or within a particulate inorganic substrate improves the storage stability and/or thermal stability of the at least one reactive dye or ink, which typically includes relatively unstable compounds. This allows the present indicators to be incorporated into thermoplastic polymer materials and processed conventionally while maintaining the efficacy and stability of the new indicators. The indicators provide simple, reliable, and cost effective detection means for detecting analytes such as ammonia, carbon dioxide, and oxygen, and may find use in applications such as food packaging and medical applications.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 29, 2014
    Assignee: University of Strathclyde
    Inventors: Andrew Mills, Pauline Grosshans, Graham Skinner
  • Patent number: 8785210
    Abstract: Test kit for the detection of an analyte in an aqueous solution, including chromatographic test strips for a hapten-antihapten complex and first and second standardized vessels for receiving and positioning test strips, which include first and second hapten-coupled receptors against the analyte dried onto the interior wall for the formation of the hapten-antihapten complex, where a portion of the standardized vessels further include a known amount of analyte embedded in a glass-like layer of trehalose, which are dried onto the interior wall of the control vessel so that they dissolve during reaction of the sample with the hapten-coupled receptors. Through this standardization, analytes in unknown samples may be safely detected by immunochromatography within minutes through a hapten-antihapten complex.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: July 22, 2014
    Assignee: IfP Privates Institut fur Produktqualitat GmbH
    Inventor: Wolfgang Weber
  • Patent number: 8778685
    Abstract: The present invention provides dual labeled protein standards useful for the simultaneous determination of the molecular weight of a subject protein as well as the relative mass (i.e., amount) of the subject protein present in an electrophoresis lane. The invention is also directed to methods suitable for the preparation of such dual labeled protein standards and to methods of using such dual labeled proteins to simultaneously determine the molecular weight and the relative amount of a subject protein. Further embodiments are directed to the use dual labeled protein standards to make a more accurate determination of the amount of a protein present in an electrophoresis lane. Yet further embodiments are directed to kits containing the presently described dual protein standards. Dual labeled protein standards made and used in accordance with the embodiments set forth herein may be used to simultaneously determine the molecular weight and the relative amount of a subject protein in real time.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: July 15, 2014
    Assignee: Life Technologies Corporation
    Inventors: Thomas Diller, Timothy Updyke
  • Patent number: 8765476
    Abstract: Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle to at least one slide. A multi-treatment cleaning cycle may include a washing treatment and a drying treatment. In yet other aspects the present invention may include an automated recovery sample processing system with the capability of detecting at least one immediate condition of a fortuitously terminated automatic sample processing run and perhaps even an automatic terminated sample processing run reconstruction calculator.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: July 1, 2014
    Assignee: Biocare Medical, LLC
    Inventors: Saradha Avantsa, Ravishankar Melkote, Thomas Maxwell, Geoffrey Cook
  • Patent number: 8765484
    Abstract: The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: July 1, 2014
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Thomas Schmedake, Frederique Cunin, Jamie Link
  • Patent number: 8765483
    Abstract: Provided herein are explosives detection substrates which include an electrospun (electro)sprayed and/or dry spun aromatic polymer, such as polystyrene, and a small molecule fluorophore. Methods for detecting an explosive material using such substrates are also provided.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: July 1, 2014
    Assignee: University of Connecticut
    Inventors: Yu Lei, Ying Wang