Optical Result Patents (Class 436/164)
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Patent number: 12343724Abstract: A detection chip, a method for using a detection chip and a detection apparatus are provided the detection chip includes a chip substrate and the chip substrate includes a fluid channel and a plurality of liquid cells. The fluid channel is arranged on a surface if the chip substrate and includes a main path and a plurality of branch paths. The plurality of branch paths are respectively communicated to the plurality of liquid cells, the plurality of branch paths are all communicated to the main path, and communication points between the plurality of branch paths and the main path are different. The plurality of branch paths are configured to allow liquid in the plurality of branch paths to be capable of merging into the main path in a same direction.Type: GrantFiled: February 1, 2021Date of Patent: July 1, 2025Assignees: BEIJING BOE HEALTH TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Lijiao Hu, Haochen Cui, Xiaohe Shen, Chungen Yuan, Tao Hu, Jing Li, Weiqiong Gan
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Patent number: 12292439Abstract: The present disclosure relates to a method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance, by which the surface of a target substance can be easily coated with metal nanoparticles through centrifugation, a substrate for detecting a target substance manufactured thereby, and a method for detecting a target substance using the same.Type: GrantFiled: March 27, 2020Date of Patent: May 6, 2025Assignee: Exopert CorporationInventors: Yeon Ho Choi, Hyun Ku Shin
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Patent number: 12276587Abstract: The invention relates to a method for preparing a substrate comprising a sample reception area and a sensing area. The method comprises the steps of: 1) applying a sample on the sample reception area; 2) rotating the substrate around a predetermined axis; 3) during rotation, at least part of the liquid travels from the sample reception area to the sensing area due to capillary forces acting between the liquid and the substrate; and 4) removing the wave of particles and liquid formed at one end of the substrate. The sensing area is closer to the predetermined axis than the sample reception area. The sample comprises a liquid part and particles suspended therein.Type: GrantFiled: October 9, 2023Date of Patent: April 15, 2025Assignee: Danmarks Tekniske UniversitetInventors: Onur Durucan, Michael Stenbaek Schmidt, Tomas Rindzevicius, Anja Boisen
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Patent number: 12277468Abstract: Provided are a magnetic bead-based detection method, a storage medium, and a detection device. The detection method includes: collecting a white light image of a to-be-detected solution, in which the to-be-detected solution is mixed with a to-be-detected sample and magnetic beads with a capture agent (S1); determining magnetic stripe regions in the white light image, and determining first magnetic bead regions based on the magnetic stripe regions (S2); selecting, by using a first neural network, second magnetic bead regions containing magnetic beads from the first magnetic bead regions, and obtaining a marker position of each of the magnetic beads (S3); and obtaining, by using a second neural network and based on each of the second magnetic bead regions, codes at code bits of a corresponding magnetic bead, and obtaining corresponding code information based on the codes of the code bits and the marker position of the magnetic bead (S4).Type: GrantFiled: April 30, 2024Date of Patent: April 15, 2025Assignee: BGI SHENZHENInventors: Wenwei Zhang, Mei Li, Weimao Wang, Yuxiang Li, Xun Xu
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Patent number: 12251537Abstract: A syringe device and methods for device for separating liquids of different densities are provided where the syringe device includes a hollow syringe barrel, a perforated plunger seal with a seal hole, and a hollow plunging tube with a closed bottom with at least one tube hole.Type: GrantFiled: August 4, 2020Date of Patent: March 18, 2025Assignee: Board of Trustees of Southern Illinois UniversityInventors: Ashim Gupta, Michael W. Neumeister, Sohyung Cho, Scott Moore, Robert B. Zajeski, Jr.
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Patent number: 12251405Abstract: Processes for production of a composition containing active follistatin via spray/heat drying of a biological source containing follistatin as well as compositions containing this active follistatin and methods it use increasing muscle mass are provided.Type: GrantFiled: October 4, 2018Date of Patent: March 18, 2025Assignee: MYOS CORP.Inventors: Maghsoud Dariani, Neerav Padliya, Alexander Tess
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Patent number: 12248900Abstract: Exemplary embodiments are disclosed of systems and methods for quality monitoring of pallets of goods (e.g., fresh seafood, other perishable goods, nonperishable goods, etc.) in a cargo.Type: GrantFiled: October 28, 2022Date of Patent: March 11, 2025Assignee: Copeland Cold Chain LPInventors: Alexander Axelsson, Casimir E. Lawler, Jr.
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Patent number: 12226767Abstract: An apparatus includes one or more valves adapted to be coupled to corresponding reagent reservoirs and a flow cell interface adapted to be coupled to a flow cell. The apparatus includes a sample cartridge interface having one or more ports and adapted to be coupled to a sample cartridge carrying a sample of interest. The sample cartridge interface positioned downstream of the flow cell interface. The apparatus includes a pump adapted to load a channel of the flow cell with the sample of interest via the flow cell interface associated with an outlet of the flow cell and a corresponding port of the sample cartridge interface.Type: GrantFiled: September 16, 2020Date of Patent: February 18, 2025Assignee: ILLUMINA, INC.Inventors: Bradley Drews, Reto Schoch, Tarun Khurana, Minsoung Rhee
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Patent number: 12210029Abstract: A diagnostic analyzer includes a rotating device, a first optical reader, and a second optical reader. The rotating device includes a first darkened compartment, a second darkened compartment, and an optical path along which the first darkened compartment and the second darkened compartment travel. The first optical reader is operable to read the first darkened compartment and the second optical reader is operable to read the second darkened compartment.Type: GrantFiled: August 2, 2023Date of Patent: January 28, 2025Assignee: Abbott LaboratoriesInventor: Robert Luoma
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Patent number: 12209907Abstract: A method for determining an optical pathlength through a cuvette of a spectrophotometric apparatus includes obtaining a first single beam spectrum of a liquid zero-material at least in a first energy region in which the liquid zero-material absorbs at least a portion of incident optical radiation; obtaining a second single beam spectrum of a second liquid at least in the first energy region, the second liquid having a composition excluding the liquid zero-material and having no absorption of incident optical radiation in the first energy region; determining a dual beam spectrum of the liquid zero-material relative to the second liquid at least in the first energy region from the first and second single beam spectra; and calculating an optical pathlength through the cuvette based on processing spectral information obtained from the first energy region of the determined dual beam spectrum.Type: GrantFiled: October 15, 2020Date of Patent: January 28, 2025Assignee: FOSS Analytical A/SInventor: Jeppe Sandvik Clausen
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Patent number: 12179198Abstract: A system for handling biological cells includes a main channel having an inlet end and an outlet end, and, at least over a first portion from the inlet end, including a cross section such that a cell circulating in the portion undergoes mechanical stresses. The system further includes first means for detecting the presence of a cell at the inlet end of the main channel and at least one access zone opening into the main channel between its inlet end and its outlet end in the first portion, in order to make it possible to exert an action on the cell. The system also includes means for displacing the cell in order to control the displacement of the cell between the inlet end and the outlet end.Type: GrantFiled: January 5, 2018Date of Patent: December 31, 2024Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Vincent Agache, Fabrice Casset, Stephane Fanget, Yves Fouillet, Arnaud Millet
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Patent number: 12181417Abstract: Disclosed are a measurement system for micro-mixing and a measurement method thereof. The measurement system comprises a mixing device, a light enhancement unit, an observation unit, an image acquisition unit, a display device and a tracer injection device; the light enhancement unit comprises a light-emitting device, a light-focusing device and a reflecting device; the observation unit comprises an observation window; the image acquisition unit comprises a distortion-free lens and an image acquisition device which are connected in sequence, and a central axis of the distortion-free lens is in alignment with a central axis of the observation window. The measurement method is performed in the measurement system provided by the present application. In the present application, the brightness of visual field is improved, the light interference on target image is shielded off, the process of micro-mixing can be observed in real time, and thereby the micro-mixing efficiency can be evaluated.Type: GrantFiled: January 25, 2024Date of Patent: December 31, 2024Assignees: INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES, NANJING JIUZHANG CHEMICAL TECHNOLOGY CO., LTD., ZHEJIANG GREATWALL MIXERS CO., LTD.Inventors: Chao Yang, Xiaoxia Duan, Xin Feng, Dingwang Huang, Jie Chen, Weipeng Zhang, Zheng Li, Yuanyuan Li, Zaisha Mao, Minghui Xie
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Patent number: 12181468Abstract: The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.Type: GrantFiled: March 8, 2021Date of Patent: December 31, 2024Assignee: Zoetis Services LLCInventors: Rajesh K. Mehra, Kenneth P. Aron
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Patent number: 12140547Abstract: The present disclosure relates to a surface-enhanced Raman spectroscopy complex probe capable of effectively detecting a catecholamine compound even at extremely low concentrations. The complex probe includes a nanolaminate including a nanogap and metal nanoparticles. In this case, the nanolaminate and the metal nanoparticles are modified to a compound that may be bound to each functional group included in catecholamine, and thus, catecholamine included in an analyte is doubly recognized by the complex probe. In addition, since a hotspot emitting a strong SERS signal is formed by a nanogap included in a nanolaminate, it is possible to effectively detect a catecholamine compound even at extremely low concentrations.Type: GrantFiled: January 28, 2022Date of Patent: November 12, 2024Assignees: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE, VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.Inventors: Eun-Ah You, Zhou Wei, Wonil Nam, Wansun Kim
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Patent number: 12135271Abstract: The invention is based on a sensor device (10) with at least one sensor unit (12) comprising at least one laser unit (14) for a generation of at least one laser beam (16) and comprising at least one detection unit (18) for a detection of, in particular reflected, laser beams (20), with an evaluation unit (22) which is configured to process detected laser beams (20) into at least one sensor signal (39), and with a control unit (26) which is configured, in a continuous operation state, to actuate the sensor unit (12) and the evaluation unit (22) for an operation of the sensor unit (12) and the evaluation unit (22) in alternating switch-on intervals (31, 43) and switch-off intervals (33, 45). It is proposed that the evaluation unit (22) is configured to generate the at least one sensor signal (39) from at least two different switch-on intervals (31) of the sensor unit (12).Type: GrantFiled: September 24, 2021Date of Patent: November 5, 2024Assignees: Robert Bosch GmbH, TRUMPF Photonic Components GmbHInventors: Soeren Sofke, Tarek Zaki
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Patent number: 12078647Abstract: Assay systems including assay apparatus and handheld assay devices for use therewith for obtaining diagnostic information of a bodily specimen. Assay devices include a cartridge housing snugly accommodating a specimen slide intended for elevation from an initial lowermost specimen introduction position to a final uppermost specimen examination position in which a bodily specimen is compressed between a cartridge housing top face and a specimen slide. Assay devices preferably include a liquid reagent dispensing arrangement for dispensing liquid reagent on a specimen slide for reacting with a bodily specimen.Type: GrantFiled: May 13, 2022Date of Patent: September 3, 2024Assignee: GYNTOOLS LTDInventors: Menachem Lev-Sagie, Nimrod Lev, Tal Shlomovitz, Zohar Horowitz Limor
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Patent number: 12066383Abstract: Analyte collection and testing systems and methods, and more particularly to testing systems and methods that achieve significant improvements in the detection of fluorescence signals in the reader by modulating the applied optical excitation. Also described herein are optical detection apparatuses and methods for removable photonic chips that do not require translation for calibration when coupling the photonics chip with the sensing system. Also described herein are methods and apparatuses for accurately calibrating a dilution factor when reading from a photonics chip.Type: GrantFiled: December 18, 2019Date of Patent: August 20, 2024Assignee: Aspida DX Inc.Inventors: Hardeep Sanghera, Ashutosh Shastry, David Piehler, Yun-Pei Chang
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Patent number: 12013334Abstract: According to an aspect of the invention, a specimen information detection apparatus includes, an image capture device configured to capture an image of a specimen container that contains a specimen, an illumination device configured to irradiate the specimen container with light sideways with respect to an image capturing direction when the image is captured, and an information processing portion configured to detect a state in the specimen container through image processing based on image information of the specimen container acquired by capturing the image of the specimen container.Type: GrantFiled: July 7, 2021Date of Patent: June 18, 2024Assignee: Aoi Seiki Co., Ltd.Inventor: Teruaki Itoh
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Patent number: 11982604Abstract: Methods and systems of analyzing and quantifying a surface acidity on a low surface area sample are disclosed. The methods include analyzing a quantity of an effluent molecular probe desorption from a temperature programmed desorption (TPD) process and system, by employing a mass spectroscopy (MS) system. The molecular probe is chemically adsorbed on a clean surface of the sample before the TPD process. The sample has a surface area to mass ratio of less than 5 m2/g. In some embodiments, the total surface area analyzed in the method can be as low as 3 m2.Type: GrantFiled: October 8, 2019Date of Patent: May 14, 2024Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.Inventors: Tritti Siengchum, James M Ralph
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Patent number: 11977352Abstract: Digital holographic microscopy and related image processing techniques are described. A hologram captured in an image frame is split into different depths while a new hologram is being captured. Image slices of the hologram are determined and using free space impulse responses that are pre-calculated at a different precision than processing operations using the holographic data. Each computation is calculated in parallel based on the number of available processing cores and threads. The image slices are combined into a 2D array or 3D array to permit further processing of the combined array to count and size particles in the image frame. The reconstructed hologram is displayed at a subsequent image frame than that used to capture the hologram.Type: GrantFiled: March 26, 2021Date of Patent: May 7, 2024Assignee: Intel CorporationInventors: Jakub Wenus, Niall Cahill, Inbarasan Muniraj, Ashley Deflumere, Michael McGrath
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Patent number: 11959912Abstract: A fluorescence immunochromatographic detection card and a preparation method therefor and usage thereof is disclosed. The fluorescence immunochromatographic detection card comprises a treatment liquid A, a treatment liquid B, and a detection card. The treatment liquid A contains an antibody 15C4 that is coupled with a fluorescent microsphere. The treatment liquid B contains an antibody 13G12 that is coupled with biotin. The detection card comprises a detection line area and a quality control line area, and a streptavidin detection T line is fixed in the detection area, and an antibody quality control C line is immobilized in the quality control line area. The preparation method comprises: (1) formulating the treatment liquid A; (2) formulating the treatment liquid B; and (3) drawing the line on the detection card.Type: GrantFiled: May 26, 2017Date of Patent: April 16, 2024Assignee: Wuhan Newcando Biotechnology Co., Ltd.Inventors: Honghao Sun, Hui Zhu, Changrong Zhou
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Patent number: 11940403Abstract: A device for the detection of a food allergen includes a sensor having a printed circuit board and a chip comprising a molecularly imprinted polymer (MIP) and a non-imprinted polymer (NIP); a reservoir comprising a liquid; and a chamber for mixing the liquid with a food.Type: GrantFiled: May 1, 2018Date of Patent: March 26, 2024Assignee: Amulet, Inc.Inventors: Srikanth Rao Agnihotra, Madanodaya Sundhoro, Brent Amberger, Abigail Barnes, Joseph Belbruno, Seung Hyuk Noh, Jeanette Numbers, Elizabeth Soucy
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Patent number: 11925456Abstract: A method comprising at least one light source configured to generate a light of at least one wavelength and project the light over an optical path, a sample device, the device containing a sample obtained from exhalation of a person, a vortex mask configured to receive the light after the light passes through at least a portion of the sample device, the vortex mask including a series of concentric circles etched in a substrate, the vortex mask configured to provide destructive interference of coherent light received from the at least one light source, a detector configured to detect and measure wavelength intensities from the light in the optical path, the wavelength intensities being impacted by the light passing through the sample, the detector receiving the light that remained after passing through the vortex mask, and a processor configured to provide measurement results based on the wavelength intensities.Type: GrantFiled: October 1, 2020Date of Patent: March 12, 2024Assignee: Hyperspectral Corp.Inventors: David M. Palacios, Harry Hopper
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Patent number: 11899013Abstract: According to one embodiment, a method of detecting or quantifying a detection target in a specimen includes: irradiating a reaction mixture containing composite particles and the specimen with light to promote binding between the composite particles and the detection target; and performing measurement on the reaction mixture irradiated with the light to detect or quantify the detection target. The composite particles each include a carrier particle including two or more regions having different physical properties on a surface, and an affinity substance carried on the carrier particle and having affinity to the detection target. The light can be absorbed by at least one of the two or more regions.Type: GrantFiled: June 24, 2020Date of Patent: February 13, 2024Assignee: Canon Medical Systems CorporationInventors: Satoru Sugita, Hirotoshi Tahara
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Patent number: 11900704Abstract: The method to determine tampering of a security label (102) comprises, associating at least a portion of a first pattern to an external reference (110), wherein a first layer (202) of the security label (102) comprises the first pattern. Further, a second pattern (206) defined in a second layer (204) is used to change the contour of the portion of the first pattern, when the security label (102) is at least partially disengaged from a surface. Subsequently, when there is change in contour of the portion of the first pattern, the portion of the first pattern is disassociated from an external reference (110). Further, the portion of the first pattern and the external reference (110) are scanned and finally tampering of the security label (102) is determined based on the association between the portion of the first pattern and the external reference (110).Type: GrantFiled: March 14, 2019Date of Patent: February 13, 2024Inventor: Ashish Anand
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Patent number: 11892390Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.Type: GrantFiled: April 24, 2020Date of Patent: February 6, 2024Assignee: New York UniversityInventors: David G. Grier, Fook Chiong Cheong, Ke Xiao
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Patent number: 11892394Abstract: The present invention relates to a device for a light-spectroscopic analysis of a sample, wherein said sample is, for example, a liquid sample. Said sample can be detected and/or analyzed photometrically, spectrophotometrically, fluorometrically, spectrofluorometrically and/or with the aid of phosphorescence or luminescence by means of such a device.Type: GrantFiled: February 4, 2020Date of Patent: February 6, 2024Assignee: Implen GmbHInventors: Thomas Sahiri, Stephan Kapfinger
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Patent number: 11866779Abstract: MALDI-MS operated slightly under matrix storm conditions with a high-energy-transfer, acidic matrix, or these conditions with a high sample to matrix ratio, can with ultrasensitivity detect a nucleobase, modified or canonical, of a nucleic acid species as a jettisoned, protonated molecule.Type: GrantFiled: February 28, 2019Date of Patent: January 9, 2024Assignee: Northeastern UniversityInventors: Roger W. Giese, Poguang Wang
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Patent number: 11867707Abstract: Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.Type: GrantFiled: December 22, 2020Date of Patent: January 9, 2024Assignee: iCubate, Inc.Inventors: Jeff Bertrand, Jian Han, Phillip Ewing
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Patent number: 11819842Abstract: A system for buoyant separation includes a separation container. Additionally or alternatively, the system can include an automated instrument, one or more processing components, and/or any other components. A method for buoyant separation can include any or all of: manipulating the separation container; adding materials to the separation container; removing materials form the separation container; otherwise processing the separation container; and/or any other processes.Type: GrantFiled: August 26, 2022Date of Patent: November 21, 2023Assignee: Akadeum Life Sciences, Inc.Inventors: Casey Wegner, William Lloyd, Brandon H. McNaughton, Brittany MacIntyre
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Patent number: 11802856Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.Type: GrantFiled: May 18, 2022Date of Patent: October 31, 2023Assignee: Thermo Finnigan LLCInventors: Joshua T. Maze, Scott T. Quarmby
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Patent number: 11788128Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.Type: GrantFiled: September 23, 2020Date of Patent: October 17, 2023Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Patent number: 11754564Abstract: A reagent test paddle includes a contamination detection medium, a reference color bar, at least one chemical test medium, and a unique identifier. The contamination detection medium includes a reagent that changes color in the presence or when exposed to a hostile or inhospitable environment. Each chemical test medium includes a regent that is responsive to a respective analyte in a biological sample. The reference color bar includes reference color samples of different colors. The unique identifier, like a serial number, identifies the particular paddle and its chemical test medium so it can be uniquely and anonymously associated with a user.Type: GrantFiled: March 19, 2021Date of Patent: September 12, 2023Assignee: HEALTHY.IO LTD.Inventors: Bernard Burg, Martin Zizi, Walter De Brouwer, Jaime Tenedorio, Babak Aghazadeh, Jie Cui, Sheena Menezes
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Patent number: 11733169Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.Type: GrantFiled: December 14, 2020Date of Patent: August 22, 2023Assignee: ALVERIX, INC.Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
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Patent number: 11733157Abstract: A method of measuring a gas concentration is described. The method comprises illuminating, with a light source, a volume of space that includes a gas and measuring, with a detector, a first illumination level of the volume of space. The method further comprises determining, via a processor, a gas concentration in the volume of space based on the measured first illumination level, where the volume of space is configured to be in fluid communication with a gas recirculation flow path including a catalyst, the catalyst configured to substantially remove the gas from the volume of space.Type: GrantFiled: July 6, 2020Date of Patent: August 22, 2023Assignee: Honeywell International Inc.Inventors: Daniel Pearce, Richard B. Fox, Jan Ludvik, Ian Kerr, John Rogers
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Patent number: 11724255Abstract: A fluid sample testing apparatus has a housing with a test chamber and first and second fluid collector tubes and first and second fluid collectors in fluid communication with the test chamber. A sample holding container is in fluid communication with the second fluid collector tube. The first fluid collector is inserted into the first fluid collector tube and pressure is generated to release fluid from the first fluid collector into the test chamber, and air passes outside of the apparatus from the test chamber via an opening from the test chamber into the first fluid collector tube. The second fluid collector is inserted into the second fluid collector tube concurrently and pressure is generated to release fluid from the second fluid collector into the sample holding container, and air passes outside of the apparatus from the second fluid collector tube.Type: GrantFiled: February 14, 2020Date of Patent: August 15, 2023Assignee: MARSHALL VENTURE PARTNERS LLCInventors: Alan R Loudermilk, Herbert Hunt Allred, Kevin Fuller, Wayde J Altendorf
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Patent number: 11674942Abstract: A sensor assembly may include a chassis, cover, first sensor, second sensor, and a control system. The chassis may include a first housing that defines a chamber with the cover and includes a partition within the chamber. A second housing of the chassis may define first and second ports in fluid communication with the chamber. A central wall may extend from an inner surface of the second housing and a protruding wall may extend over the central wall. Both the partition and the central wall may extend from locations along a longitudinal axis of the sensor assembly that are between the first port and the second port. In some examples the protruding wall and the partition direct a portion of fluid flowing within the second housing into and out of the chamber, and the first and second sensors detect values for respective fluid parameters for the portion of fluid.Type: GrantFiled: October 11, 2022Date of Patent: June 13, 2023Assignee: Swim Sense, LLCInventors: Rakesh Reddy, Kevin Doyle
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Patent number: 11662354Abstract: The invention relates to a method and a computer program for estimating a bilirubin level of a neonate, composed of the steps of: Acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate, Acquiring a plurality of covariates from the neonate, each composed of an information about a neonatal property, Providing a pre-defined bilirubin model function, wherein the bilirubin model function is configured to describe a time course of a bilirubin level of a neonate, Determining a plurality of model parameters of the bilirubin model function, wherein each model parameter is estimated from at least one covariate of the plurality of covariates and an associated population model parameter, Determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.Type: GrantFiled: March 15, 2022Date of Patent: May 30, 2023Assignee: UNIVERSITÄT BASELInventors: Gilbert Koch, Sven Wellmann, Marc Pfister, Severin Kasser, Melanie Wilbaux
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Patent number: 11642669Abstract: The disclosure relates to methods of manufacturing and using a single layer microfluidic for detecting target analytes, including obtaining a single layer sheet of paper; depositing wax boundaries onto the paper in a plurality of patterns including a main channel, fluid transfer channels, and an independent diagnostic area corresponding to each fluid transfer channel; melting the wax through the paper; depositing diagnostic components onto the diagnostic areas; depositing a continuous wax backing; and cutting devices from the paper. The disclosure also relates to a method of capturing an image of the micro fluidic device to generate diagnostic results corresponding to the diagnostic components by: identifying at least two panels from the image; and determining a color for each panel of the at least two panels; and generating for display, using the computing device, a graphical user-interface including at least one component visualizing the diagnostic results.Type: GrantFiled: October 16, 2018Date of Patent: May 9, 2023Assignee: Group K Diagnostics, Inc.Inventor: Brianna Wronko
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Patent number: 11619549Abstract: The present disclosure provides for an apparatus for measuring optical properties of liquid samples. The apparatus includes a sample chamber and a spectrometer optically coupled with the sample chamber. One or multiple sources of electromagnetic radiation are positioned relative to the sample chamber to direct electromagnetic radiation through the sample chamber to measure the color, haze, and/or clarity of the sample. Also provided is a method for measuring optical properties of liquid samples, including inserting a cuvette containing a liquid sample into the sample chamber of the apparatus, and directing electromagnetic radiation from the one or more sources and through the sample to measure the color, haze, and/or clarity of the sample. The apparatus and methods may be used to analyze various samples, such as petroleum-based fluids, including fuels and lubricants.Type: GrantFiled: March 1, 2021Date of Patent: April 4, 2023Inventor: Ranzy Morgan, III
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Patent number: 11607025Abstract: Systems, devices, and methods for a cosmetic sponge having: a tip portion at one end of the cosmetic sponge; an angled portion, where the tip portion is surrounded by the angled portion; a bulbous portion, where the bulbous portion is disposed proximate a bottom of the cosmetic sponge; and a bottom portion, where the bottom portion is surrounded by the bulbous portion; and a thermochromic pigment in at least a portion of the cosmetic sponge, where the portion of the cosmetic sponge changes from a first color at a first temperature to a second color at a second temperature.Type: GrantFiled: November 16, 2021Date of Patent: March 21, 2023Assignee: REA.DEEMING BEAUTY, INC.Inventors: Rea Ann Silva, Brittany Blass
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Patent number: 11607698Abstract: The invention is intended for the organization of an automated process for spraying of liquid means of chemical treatment from unmanned vehicles, for example, in precise farming systems. The invention provides the use of a replaceable, marked and hermetically sealed liquid subsystem with integrated pumping chambers in a spraying device together with an integrated self-diagnosis system allowing to ensure personnel safety and the accounting of the resources of main components of the spraying device. All this in combination enables to create fully automated spraying systems.Type: GrantFiled: August 20, 2018Date of Patent: March 21, 2023Assignee: ROBOTOPIA UABInventors: Sergey Odinokov, Linas Samuolis
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Patent number: 11585739Abstract: There is provided a nucleic acid extraction method using a cartridge comprising: (a) a driving part of a nucleic acid extraction device is connected to a control rod module disposed in an inner space of the upper body of a piston and a rotation control module coupled to the lower body of the piston; (b) driving the rotation control module and the control rod module, sequentially sucking sample and reagents from the plurality of chambers separated from each other into an interior space, and discharging the mixture of the interior space into the chamber of the cartridge; and (c) driving the rotation control module and the control rod module to suck the reagent inside the master mix bead chamber of the cartridge into the interior space of the piston upper body and then discharge the mixed reagent to a nucleic acid amplification module.Type: GrantFiled: December 20, 2018Date of Patent: February 21, 2023Assignee: SD BIOSENSOR, INC.Inventors: Young Shik Cho, Hyo Guen Lee, Hae Joon Park, Sun Young Lee, Kwan Hun Lim, In Ae Kim, Jae Young Kim, Hyo Lim Park, Dong Hun Kim
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Patent number: 11584776Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.Type: GrantFiled: May 15, 2020Date of Patent: February 21, 2023Assignee: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Surin Mong
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Patent number: 11554384Abstract: The present invention relates to a method for manufacturing structural layers for guiding liquid flow on a porous substrate, by printing onto at least one area of at least one surface of the substrate a printing solution containing an aqueous dispersion of a poly(lactic acid)-based copolymer.Type: GrantFiled: April 9, 2020Date of Patent: January 17, 2023Assignee: Teknologian tutkimuskeskus VTT OyInventors: Kaisa Kiri, Adina Anghelescu-Hakala
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Patent number: 11525773Abstract: The present invention relates to the field of biochemical detection, and in particular to a reading apparatus for reading an assay result on a testing element. The reading apparatus comprises a first light-emitting element, a first photodetector and a light blocking element, wherein the first light-emitting element emits light and illuminates one or more corresponding areas of the testing element, the first photodetector receives light from one or more corresponding areas of the testing element, and the light blocking element guides a path of light emitted from a light emitting element and/or from a testing element. The light blocking element separates photodetectors in separate spaces, including a first light blocking element and a second light blocking element, wherein the first light blocking element is located between the first light-emitting element and the first photodetector, to guide the light emitted from the light emitting element to illuminate the testing element.Type: GrantFiled: July 19, 2019Date of Patent: December 13, 2022Assignees: ZHEJIANG ORIENT GENE BIOTECH CO., LTD.Inventors: Jianqiu Fang, Fangzhou Xu, Xiulong Ge
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Patent number: 11513078Abstract: Distributed fiber optic sensors formed by covering the fibers with tubing are provided. The tubing including responsive materials formulated or configured to, responsive to exposure to one of a target chemical species and a target radiation particle, change a relative size and generate a localized effect on or in the optical fiber.Type: GrantFiled: November 2, 2020Date of Patent: November 29, 2022Assignees: Consolidated Nuclear Security, LLC, The University of Tennessee Research FoundationInventors: Vincent E. Lamberti, Dayakar Penumadu
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Patent number: 11446659Abstract: The present invention discloses a nucleic acid extraction apparatus and a method using the apparatus for extracting nucleic acids and amplifying target nucleic acids. The nucleic acid extraction apparatus comprising: a nucleic acid extraction element, a waste storage chamber, and a reaction chamber, wherein the reaction chamber is selectively in communication with the nucleic acid extraction element and the waste storage chamber, and the apparatus realizes fluid exchange through the pressure between the waste storage chamber and the reaction chamber. In the present invention, by using an integrated control system, the conventional manual process of nucleic acid extraction and purification is integrated into a fully automatic closed process, making the operation more conveniently and quickly and improving the efficiency of experimental work.Type: GrantFiled: July 29, 2019Date of Patent: September 20, 2022Assignee: HANGZHOU BIGFISH BIO-TECH CO., LTD.Inventor: Lianyi Xie
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Patent number: 11351510Abstract: The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.Type: GrantFiled: June 1, 2018Date of Patent: June 7, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Darren Roy Link, Michael Weiner, David Marran, Jonathan M. Rothberg
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Patent number: 11350017Abstract: Calibration requests are received at a network service. The network service assigns a request identifier for the data of a request. The request identifier is encoded into a control strip on a test color sheet using color patches. A color encoding key encodes the request identifier using the color patches. After the test color sheet is printed, a color measurement tool is used to decode the information from the control strip, including the request identifier. The color measurement tool measures the test color strips on test color sheet. The request identifier corresponds to the measurement data. The measurement data along with the request identifier is sent to the network service. The measurement data is processed to generate calibration data, which is used to update the printing device.Type: GrantFiled: January 14, 2021Date of Patent: May 31, 2022Assignee: Kyocera Document Solutions Inc.Inventor: Steve A. Doria