Inorganic Standards Or Controls Patents (Class 436/19)
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Patent number: 10877053Abstract: A method of determining an analyte concentration in a sample by a sensor is disclosed. The method includes analyzing a sample signal generated by the sensor for an analyte being measured. If the sample signal is normal, the method includes comparing the sample signal with a first reference signal of a reference solution measured prior to measuring the sample in order to determine the analyte concentration. If the sample signal is abnormal, the method includes comparing the sample signal with a calculated reference signal point obtained by interpolation between the first reference signal and a second reference signal of the same reference solution measured after measuring the sample. Various methods of determining and handling errors based on signal patterns are also disclosed.Type: GrantFiled: March 5, 2018Date of Patent: December 29, 2020Assignee: Roche Diagnostics Operations, Inc.Inventor: Li Gan
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Patent number: 10809273Abstract: A method of determining an analyte concentration in a sample by a sensor is disclosed. The method includes analyzing a sample signal generated by the sensor for an analyte being measured. If the sample signal is normal, the method includes comparing the sample signal with a first reference signal of a reference solution measured prior to measuring the sample in order to determine the analyte concentration. If the sample signal is abnormal, the method includes comparing the sample signal with a calculated reference signal point obtained by interpolation between the first reference signal and a second reference signal of the same reference solution measured after measuring the sample. Various methods of determining and handling errors based on signal patterns are also disclosed.Type: GrantFiled: March 5, 2018Date of Patent: October 20, 2020Assignee: Roche Diagnostics Operations, Inc.Inventor: Li Gan
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Patent number: 9022865Abstract: In some embodiments, a player may influence the volatility of a bonus round of a game by placing elements collected during a primary game onto symbol positions of the bonus round. In some embodiments, if a symbol position onto which a player placed one or more bonus round symbols is selected as an active symbol position for an event instance of the bonus round, the player wins a prize. Additionally, a multiplier may be applied to the value of the prize or other benefit may be provided to the player if the player placed more than one bonus round symbol element on the position. Thus, a player having a plurality of bonus round symbols to place may choose to increase the frequency of prizes won (e.g., by distributing the bonus round symbols over more positions) or increase the value of prizes (e.g., by grouping more symbols on fewer positions).Type: GrantFiled: April 26, 2013Date of Patent: May 5, 2015Assignee: Gamesys, Ltd.Inventors: Hans Elias, Thomas David James Aicken, Marlon James Dublin
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Patent number: 8809061Abstract: A living body phantom according to the present invention, which is used as a testing sample in a prepared slide in estimating the performance of a microscope objective lens with the image of the testing sample in the prepared slide acquired by an imaging means via the microscope objective lens and with optical characteristics obtained from the image of the testing sample, includes a non-gel-like solution at least including: a solvent which at least includes water, a refractive index adjustment agent, and a scattering body or which at least includes a refractive index adjustment agent and a scattering body; and a thickener.Type: GrantFiled: March 5, 2012Date of Patent: August 19, 2014Assignee: Olympus CorporationInventors: Asuka Mukai, Koji Yoshida
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Patent number: 8772034Abstract: A control solution packet for calibrating a bodily fluid sampling device includes a container, a control solution pressurized within the container, and a membrane for covering and sealing the container. The control solution can be pressurized before or during calibration so as to ensure the appropriate amount of control solution is delivered to the bodily fluid sampling device. The control solution is manufactured to have a viscosity that controls delivery of the control solution to the device. The membrane is permeable by a piercing device of the bodily fluid sampling device and seals around the piercing device during calibration. In another aspect, the container is in the form of a capsule or dosing attachment that contains the control solution along with a sponge-like material.Type: GrantFiled: October 24, 2011Date of Patent: July 8, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Juergen Rasch-Menges, Paul Jansen
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Patent number: 8536520Abstract: A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent.Type: GrantFiled: October 25, 2010Date of Patent: September 17, 2013Assignee: IROA Technologies LLCInventor: Christopher William Ward Beecher
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Patent number: 8532952Abstract: Methods and apparatuses are provided for creation of discrete corrosion defects with a wide range of diameter to depth aspect ratios for painted test standards. Also provided are methods for use of those test standards to characterize the corrosion under paint detection threshold, statistical reliability, and accuracy of NDI and/or NDT techniques including but not limited to flash thermography, ultrasonic testing, eddy current testing, microwave testing, shearography, and infrared testing.Type: GrantFiled: June 18, 2010Date of Patent: September 10, 2013Assignee: Concurrent Technologies CorporationInventors: Joseph Pecina, Scott Ryan, John Cargill
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Patent number: 8481331Abstract: An oxidative dye indicator composition comprising an indicator dye that has been pre-reacted with a reducing agent prior to use in an oxidizing or disinfectant sterilizing system. The pre-reacted dye, when subjected to an oxidizing disinfection or sterilization agent, such as peracetic acid or hydrogen peroxide, under goes a visible color change and thus can serve as a chemical, process, or chemical integrator, indicator. The dyes include various azines, thiazines, and oxazines compounds and the reducing agents include alkali metal alkoxides and alkaline earth metal alkoxide compounds.Type: GrantFiled: September 8, 2005Date of Patent: July 9, 2013Assignee: American Sterilizer CompanyInventors: Tricia Cregger, Randal W. Eveland, Antoinette Bower
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Patent number: 8455255Abstract: The present invention presents a silica particle containing at least one silica compound selected from a group consisting of mercapto-propyl-trimethoxysilane (MPS), mercapto-propyl-triethoxysilane (MPES), mercapto-propyl-methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hepto-3-yl)ethyl]silane (EpoPS), thiocyanatopropyltriethoxysilane (TCPS), and acryloxypropyltrimethoxysilane (AcPS), which can be provided and utilized as a label, a marker, or the like for qualitative test and quantitative test for such as prophylactic agent, therapeutic agent, diagnostic agent, diagnostic and therapeutic agent or the like in dental, medical and veterinary fields regardless of fields.Type: GrantFiled: June 7, 2007Date of Patent: June 4, 2013Assignee: The University of TokushimaInventor: Michihiro Nakamura
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Patent number: 8430747Abstract: A gaming system including a central server linked to a plurality of gaming machines and a plurality of bonus awards. The central server monitors wagers on the gaming machines. Based at least in part on the wagers the central server determines when bonus events will occur and which gaming machine(s) will provide the bonus awards. In one embodiment, the central server determines which gaming machine will provide a primary bonus award and any secondary bonus awards, wherein at least one gaming machine may be provided a plurality of bonus awards.Type: GrantFiled: July 30, 2007Date of Patent: April 30, 2013Assignee: IGTInventors: Carl V. Kniesteadt, Anthony J. Baerlocher, James A. Vasquez, Tonja M. Ferry, Erick T. Ching
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Patent number: 8388435Abstract: A method of playing a wagering game comprises receiving a wager, and generating a randomly selected first outcome of a first wagering game, the first outcome comprising a first plurality of symbols arranged in a first matrix. The method further comprises generating a randomly selected second outcome of a second wagering game, the second outcome comprising a second plurality of symbols arranged in a second matrix, and simultaneously displaying the first outcome and the second outcome on at least one display. The method further comprises detecting an occurrence of a triggering event, in response to the triggering event, copying a first special symbol occurring in the first outcome into the second outcome to yield a modified second outcome, and evaluating the first outcome and the modified second outcome for winning combinations of symbols.Type: GrantFiled: May 28, 2009Date of Patent: March 5, 2013Assignee: WMS Gaming Inc.Inventors: Peter R. Anderson, Allon G. Englman, Benjamin T. Gomez, Joel R. Jaffe, Daniel P. Louie
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Patent number: 8361394Abstract: A calibration system characterizes luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems. The calibration system has a baseplate with at least one flow-through channel, wherein the at least one channel is formed as a sample chamber for the luminescence measurement system, at least one reservoir in communication with the at least one channel and adapted to receive a liquid, and at least one focusing device integrated into a baseplate for setting a defined measurement beam focus of the luminescence measurement system to be calibrated by using a focusing surface.Type: GrantFiled: March 17, 2006Date of Patent: January 29, 2013Assignees: Bam Bundesanstalf Fuer Materialforschung und - Pruefung, Sigma-Aldrich GmbHInventors: Ute Resch-Genger, Katrin Hoffmann, Dietmar Pfeifer, Roland Nitschke, Pierre Nording
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Patent number: 8283172Abstract: A lunar dust simulant containing nanophase iron and a method for making the same. Process (1) comprises a mixture of ferric chloride, fluorinated carbon powder, and glass beads, treating the mixture to produce nanophase iron, wherein the resulting lunar dust simulant contains ?-iron nanoparticles, Fe2O3, and Fe3O4. Process (2) comprises a mixture of a material of mixed-metal oxides that contain iron and carbon black, treating the mixture to produce nanophase iron, wherein the resulting lunar dust simulant contains ?-iron nanoparticles and Fe3O4.Type: GrantFiled: February 24, 2010Date of Patent: October 9, 2012Assignee: The United States of America as Represented by the Administrator of National Aeronautics and Space AdministrationInventors: Chin-cheh Hung, Jeremiah McNatt
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Patent number: 8272934Abstract: A game device and a method allow a player to play a game on the gaming machine. The gaming machine has a main display and a user interface. The game has a main game and a bonus game. The method includes the steps of (i) allowing the player to place a wager on the main game, (ii) playing the main game and randomly establishing a result of the main game, and (iii) awarding the player an award as a function of a paytable if the result of the main game is a win. The method further includes the steps of (iv) detecting an appearance of a predetermined bonus trigger symbol during the play of the main game and responsively, randomly selecting a bonus symbol from a set of bonus symbols, repeating steps (i)-(iv), and awarding the player a bonus award if a predetermined number of unique bonus symbols are selected.Type: GrantFiled: March 25, 2009Date of Patent: September 25, 2012Assignee: Aruze Gaming America, Inc.Inventors: Scott Christopher Olive, Kent Bradley Young
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Patent number: 8168945Abstract: A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent.Type: GrantFiled: October 25, 2010Date of Patent: May 1, 2012Assignee: Metabolic Analyses, Inc.Inventor: Christopher William Ward Beecher
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Patent number: 8066958Abstract: A control solution packet for calibrating a bodily fluid sampling device includes a container, a control solution pressurized within the container, and a membrane for covering and sealing the container. The control solution can be pressurized before or during calibration so as to ensure the appropriate amount of control solution is delivered to the bodily fluid sampling device. The control solution is manufactured to have a viscosity that controls delivery of the control solution to the device. The membrane is permeable by a piercing device of the bodily fluid sampling device and seals around the piercing device during calibration. In another aspect, the container is in the form of a capsule or dosing attachment that contains the control solution along with a sponge-like material.Type: GrantFiled: May 24, 2007Date of Patent: November 29, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Juergen Rasch-Menges, Paul Jansen
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Patent number: 7949473Abstract: A method for measuring the concentration of at least two analytes in a biological liquid sample by using a set of ion selective electrodes is disclosed. The method obtains from the ion selective electrodes first voltage values representative of the concentration of sodium and potassium respectively in those biological samples, and obtains from the ion selective electrodes second voltage values representative of the concentration of sodium and potassium respectively in calibration standards. The method verifies by a predetermined procedure whether each of the second voltage values obtained by measuring the calibration standards has an abnormal value caused by a disturbance of the measurement conditions in one of the ion selective electrodes, and if this is the case, marks with a flag as doubtful the measurement results derived from the first voltage values obtained for the corresponding sample which was measured before measuring the calibration standards for sodium and potassium.Type: GrantFiled: September 21, 2007Date of Patent: May 24, 2011Assignee: Roche Diagnostics Operations, Inc.Inventor: Jürgen Rauh
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Patent number: 7871821Abstract: An artificial test soil comprises particulate, hair, and fiber components, wherein said particulate component consists of mineral, food, and plant materials, so chosen and proportioned as to correlate to a typical soil found in the home. The test soil may be used to test cleaning products by application of a known amount thereof to a surface, cleaning of said surface, and determination of the amount of said soil removed from said surface.Type: GrantFiled: December 30, 2005Date of Patent: January 18, 2011Assignee: S.C. Johnson & Son, Inc.Inventors: Mark M. Gipp, John R. Wietfeldt
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Patent number: 7820963Abstract: A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent.Type: GrantFiled: August 5, 2008Date of Patent: October 26, 2010Assignee: Metabolic Alayses, Inc.Inventor: Christopher William Ward Beecher
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Patent number: 7642094Abstract: Provided is a method of measuring a biodegradation rate of a non-natural organic compound in the presence of a biodegradation medium, characterized by including: measuring a concentration of a radioactive carbon isotope 14C in a biodegradation medium; and measuring a biodegradation rate of a non-natural organic compound from a difference between the concentration of 14C in the biodegradation medium and a concentration of 14C in modern carbon. Further, a metal such as iron in the medium can be used as an internal standard. According to the method, a biodegradation rate of a non-natural organic compound can be measured safely, simply, rapidly, and accurately without providing any special measures against radiation.Type: GrantFiled: December 12, 2003Date of Patent: January 5, 2010Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hironori Tashiro, Shinji Ito
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Patent number: 7569184Abstract: Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from which the modified specimen was obtained (e.g., from a patient's blood) is determined based on the level of an analyte in a solution formed from the modified specimen and on the level of at least one normalizing analyte. The analyte and normalizing analyte each may be an ion, compound, biochemical entity, or property of the specimen. Also disclosed are a fluid collector and a fluid collection device.Type: GrantFiled: November 5, 2004Date of Patent: August 4, 2009Assignee: Home Access Health CorporationInventors: Michael Wandell, Ilia Vinogradov, Barbara Godsey, Troy Bervig
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Patent number: 7381564Abstract: A method of calibrating the zero point of an apparatus which is used to determine the quantity of silica contained in a silica solution sample to be analysed, using a colorometric method. The colorometric method used by the apparatus consists of successively introducing the following components into the sample: a molybdate solution, a developer and a reagent. In order to determine the zero point, the developer is first introduced into the sample of silica solution to be analyzed, a first measurement is taken, followed by addition of the molybdate solution and the reducing agent to the sample, where a second measurement is take and the zero point is calculated.Type: GrantFiled: October 3, 2003Date of Patent: June 3, 2008Assignee: Hach SasInventors: Alec Matschenko, Fabien Lemaitre, Rachid Qarbi
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Patent number: 7348181Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy.Type: GrantFiled: April 6, 1999Date of Patent: March 25, 2008Assignee: Trustees of Tufts CollegeInventors: David R. Walt, Todd A. Dickinson
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Patent number: 7229830Abstract: A standard sample composition containing a complexing agent and an alkali salt, mixed with a known amount of a foodstuff, the content of at least one component of which is accurately known. The mixture is dissolved in a solvent, e.g. water, and comminuted to form a dispersion. The solvent is removed e.g. by freeze-drying or other suitable method, such that the water content of the composition is <5% by weight, preferably <1% by weight, more preferably <0.1%, most preferably <0.01% by weight of the total composition.Type: GrantFiled: November 23, 2000Date of Patent: June 12, 2007Inventor: Lars-Ove Sjaunja
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Patent number: 7141431Abstract: This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are capable of giving off multiple fluorescent emissions simultaneously, which is useful for multiplexed analysis of a plurality of analytes in a sample. The coupled complex particles carrying on their surface fluorescent nanoparticles, methods of preparing such polymer particles, and various applications and methods of using such particles are claimed.Type: GrantFiled: June 30, 2005Date of Patent: November 28, 2006Assignee: Luminex CorporationInventors: Mark B. Chandler, Don J. Chandler, Jason Bedre
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Patent number: 7122376Abstract: The invention relates to a formed tablet calibration standard-reagent for calibrating Karl Fischer reactions for determining water content in a substance, the reagent containing a first component, namely sodium tartrate dihydrate, and a second component, namely magnesium stearate. The invention further relates to a method for determining the water content of a substance using a Karl Fischer analysis. The invention further relates to a formed tablet calibration standard-reagent kit that includes a sealed package containing a formed tablet calibration standard-reagent for a Karl Fischer reaction.Type: GrantFiled: November 1, 2001Date of Patent: October 17, 2006Assignee: Facet Analytical Services and Technology, LLCInventor: Scott Andrew Miller
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Patent number: 7109035Abstract: A synthetic urine formulation, a kit including the synthetic urine formulation and a method of preparing synthetic urine are described. The urine formulation includes urine components in dried form, concentrated form or normal concentration and a compound that, when added to water, increases the temperature of the water (a “heat activator”). When the urine components are present in dried form, the synthetic urine can be provided in one or two parts. When present in concentrated form or in normal concentration, the heat activator must be provided separately. Lithium chloride is a preferred heat activator. The components can be provided in kit form, including a measuring cup with a fill line, the powdered, concentrated or normal concentration synthetic urine components, and the heat activator. Optionally, but preferably, the kit also includes a temperature measuring device to ensure that the appropriate temperature is reached.Type: GrantFiled: June 27, 2003Date of Patent: September 19, 2006
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Patent number: 7052916Abstract: Methods for incorporating a stable isotope into a protein or peptide fragment are disclosed. The methods include providing isolated isotope-labeled protein or peptide fragments and analyzing the isolated labeld fragments. In another aspect of the invention, methods for quantitatively comparing peptides in two protein or peptide fragment mixtures are provided. In these methods, protein levels are measured using stable-isotope coded protein or peptide fragments.Type: GrantFiled: May 24, 2002Date of Patent: May 30, 2006Assignee: Immunex CorporationInventor: Richard S. Johnson
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Patent number: 7049146Abstract: The present invention relates to a formed tablet calibration standard-reagent for Karl Fischer reactions to determine the water content of substances, such as pharmaceuticals, food stuffs, and oils.Type: GrantFiled: March 5, 2004Date of Patent: May 23, 2006Assignee: Facet Analytical Services and Technology, LLCInventor: Scott Andrew Miller
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Patent number: 6951718Abstract: The present invention is related to rpoB gene fragments and method for the diagnosis and identification of Mycobacterium tuberculosis and non-lubercuolsis Mycobacterial strains using rpoB gene and it's fragments.Type: GrantFiled: October 27, 2000Date of Patent: October 4, 2005Inventors: Hyeyoung Lee, Young Kil Park, Gill-Han Bai, Sang-Jae Kim, Sang-Nae Cho, Yeun Kim, Hee Jung Park
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Publication number: 20040171161Abstract: The present invention relates to a formed tablet calibration standard-reagent for Karl Fischer reactions to determine the water content of substances, such as pharmaceuticals, food stuffs, and oils.Type: ApplicationFiled: March 5, 2004Publication date: September 2, 2004Inventor: Scott Andrew Miller
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Publication number: 20040137633Abstract: Compositions and methods for reducing the rate of loss of oxygen from a solution and increasing the effective life span of oxygen-containing calibration solutions.Type: ApplicationFiled: July 24, 2003Publication date: July 15, 2004Applicant: Instrumentation Laboratory CompanyInventors: Jungwon Shin, Sohrab Mansouri, Dennis Conlon
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Publication number: 20040110298Abstract: The invention relates to a formed tablet calibration standard-reagent for calibrating Karl Fischer reactions for determining water content in a substance, said reagent containing a first component, namely sodium tartrate dihydrate, and a second component, namely magnesium stearate. The invention further relates to a method for determining the water content of a substance using a Karl Fischer analysis. The invention further relates to a formed tablet calibration standard-reagent kit, comprising a sealed package containing said formed tablet calibration standard-reagent.Type: ApplicationFiled: April 14, 2003Publication date: June 10, 2004Inventor: Scott Andrew Miller
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Patent number: 6649414Abstract: This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are capable of giving off multiple fluorescent emissions simultaneously, which is useful for multiplexed analysis of a plurality of analytes in a sample. The coupled complex particles carrying on their surface fluorescent nanoparticles, methods of preparing such polymer particles, and various applications and methods of using such particles are claimed.Type: GrantFiled: August 17, 2000Date of Patent: November 18, 2003Assignee: Luminex CorporationInventors: Mark B. Chandler, Don J. Chandler
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Patent number: 6635487Abstract: A test device for use as a fluorescent standard in microfluidic analytical detection systems includes one or more slits that correspond to, and are of similar dimension to, one or more microchannels in a detection region on a corresponding analysis chip. A fluorescent material is attached to the test device on the side opposite the illumination source such that excitation radiation passes through the slit(s), which defines the focal plane of the illumination optics, and impinges on the fluorescent material thereby causing the fluorescent material to fluoresce. By displacing the fluorescent material relative to the focal plane, the intensity of the radiation exciting the fluorescent material is dispersed relative to the intensity of the radiation at the focal plane, and concomitantly the strength of the resulting fluorescent signal is reduced.Type: GrantFiled: May 7, 2001Date of Patent: October 21, 2003Assignee: Caliper Technologies Corp.Inventors: Ernest C. W. Lee, Robert Nagle, Richard J. McReynolds, David Chazan, Robert S. Dubrow
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Publication number: 20030148527Abstract: A method of treating of hydrotest water inhibits oxygen corrosion, inhibition of MIC and safe discharge of water. The combination treatment plan reduces biocide usage in a high pH brine. The reduced overall chemical usage facilitates meeting environmental guidelines while also minimizing chemical cost. The method comprises adding an oxygen scavenger to remove oxygen and prevent or minimize oxygen corrosion; raising the hydrotest water pH, typically in excess of pH 9.5; adding a biocide in reduced amount; and adding a scale inhibitor to inhibit scale.Type: ApplicationFiled: November 13, 2002Publication date: August 7, 2003Inventor: Rupi Prasad
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Patent number: 6599746Abstract: The calibration fluid is composed of a biocompatible electrolyte that, at 37° C., exhibits a concentration of bicarbonate ions that lies in the normal physiological range of the concentration of the bicarbonate ions of the blood, exhibits a pH value that lies within a pH value range within 2 through 13 containing the value 7.41 and has a specific ionic strength. In order to enable a calibration of the sensor with a higher precision compared to a known calibration fluid of this type both in vivo as well as in vitro, the ionic strength of the fluid at 37° C. is selected such that it lies in the normal physiological range of the ionic strength of the blood.Type: GrantFiled: December 4, 2000Date of Patent: July 29, 2003Inventor: Walter Gumbrecht
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Patent number: 6451607Abstract: A control device serving as a source of control reagent for a solid-phase analytical test device is disclosed. The analytical test device analyzes a biological sample for the presence of an analyte such as an enzyme or other chemical species or a particular pH range, and registers the presence or absence of the analyte as a detectable change in an indicator. The control device contains a control reagent that produces the same indicator change and that can be transferred to the analytical test device by a sample implement such as a wet swab. The control reagent is present on the control device as a dry lamina or combination of laminae. A positive control reagent on a control device in accordance with this invention mimics the action of the analyte once it is transferred to the analytical test device, while a negative control reagent on the control device mimics the action of a sample that lacks the analyte.Type: GrantFiled: March 21, 2000Date of Patent: September 17, 2002Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Robert Pena, Terrence J. Andreasen
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Publication number: 20020048817Abstract: Process and formulation are described allowing fabrication of absorbance and fluorescence standards in cuvettes and micro-well plate, and other desirable containers, with particular application to drug discovery and high throughput screening of bioactive systems. The material medium is capable of incorporating a large number of dyes, individually or in combination, and can closely mimic real aqueous assays in optical properties such as the dye spectra, transparency, refractive index, and shapes of meniscus. The medium is compatible with addition of formulation components for control of foaming, vapor pressure, freezing point, dye bleaching, and molecular rotational correlation times. The process starts with the dispensing of a fluid dye-containing liquid into the vessel of choice, and its subsequent viscosification by chemical or physical means into a viscous gel. After further processing for stability, the container can be sealed with appropriate means.Type: ApplicationFiled: August 29, 2001Publication date: April 25, 2002Applicant: Imaging Research Inc.Inventors: Ahmad Yekta, Zahra Masoumi
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Patent number: 6358743Abstract: A carrier for contraband substances to be used as a reference for testing trace detection systems. The carrier, which has the consistency of hand cream and can be dispensed from a tube or a syringe, is inert with respect to the contraband substances and does not dissolve or degrade the plastics normally used for making luggage or computer disc cases. After the carrier (with added contraband substance) has been placed on a hard surface such as a plastic luggage handle and dried, the contraband substance can be sampled by wiping with a paper or cloth, which is then tested in a device that uses ion mobility spectrometry, gas chromatography, chemiluminescence, or a combination of these methods.Type: GrantFiled: July 6, 2000Date of Patent: March 19, 2002Assignee: The United States of America as represented by the Secretary of TransportationInventor: Francis T. Fox
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Patent number: 6294388Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: GrantFiled: April 2, 1999Date of Patent: September 25, 2001Assignee: Symyx Technologies, Inc.Inventor: Miroslav Petro
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Patent number: 5891730Abstract: Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and may be interpreted by CO-oximeter instrument systems as providing a spectrum substantially equivalent to the spectrum of blood, particularly with regard to hemoglobin and hemoglobin CO-ox fractions. Dye-based reference materials may be formulated to provide CO-ox fractions approximating those seen in a clinical setting, including normal physiological CO-ox fractions. The dye-based reference materials may be combined with other ingredients thus making the materials useful as references for pH and blood gas instruments and/or electrolyte instruments in addition to CO-oximeter instrument systems.Type: GrantFiled: February 28, 1997Date of Patent: April 6, 1999Assignee: Chiron Diagnostics CorporationInventors: Jay J. Li, Justin E. Davey, David P. Swist, Liann Voo
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Patent number: 5637505Abstract: Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and may be interpreted by CO-oximeter instrument systems as providing a spectrum substantially equivalent to the spectrum of blood, particularly with regard to hemoglobin and hemoglobin CO-ox fractions. Dye-based reference materials may be formulated to provide CO-ox fractions approximating those seen in a clinical setting, including normal physiological CO-ox fractions. The dye-based reference materials may be combined with other ingredients thus making the materials useful as references for pH and blood gas instruments and/or electrolyte instruments in addition to CO-oximeter instrument systems.Type: GrantFiled: May 19, 1995Date of Patent: June 10, 1997Assignee: Chiron Diagnostics CorporationInventors: Jay J. Li, Justin E. Davey, David P. Swist, Liann Voo
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Patent number: 5633166Abstract: In high volume laboratory analysis of patient medical specimens, control materials are inserted at periodical intervals (e.g. once per eight hours) and analyzed. If the results of the analysis deviate from the mean according to statistical rules, the run of analyses prior to the insertion of control materials has in the past been rejected, often causing a substantial loss of results because the control materials were not inserted sufficiently frequently. According to the invention the patient mean of a test is determined, and when the mean deviates from the predetermined mean by more than a selected amount, this determination is used, not to reject the run, but rather to trigger insertion and analysis of control materials. If the analysis of control materials shows that the run is in control, the analyses made prior thereto are reported and the run is resumed. If the control material analysis shows that the run is out of control, then the prior analyses are rejected.Type: GrantFiled: January 19, 1995Date of Patent: May 27, 1997Assignee: MDS Health Group LimitedInventors: James O. Westgard, Paul Mountain
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Patent number: 5559035Abstract: Solid phase ionic calibration standards are disclosed that comprise sparingly and selectively soluble solids. The calibration standards are especially useful in calibration pH electrodes used to monitor weak ionic strength solutions, and permit rapid pH electrode recovery times.Type: GrantFiled: December 7, 1994Date of Patent: September 24, 1996Assignee: Umpqua Research CompanyInventor: Clifford D. Jolly
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Patent number: 5435171Abstract: An apparatus for supplying a solution of a powdery product as a specimen of viscosity measurement. The apparatus includes electronic discharge-weighing device (4) for determining the amount of the powdery sample in sample container (2), introduced into hopper (6) and discharged therefrom by vibration-generating drive (5); dissolution container (12) for receiving and dissolving the powdery sample from hopper (6); electronic balance (13)for weighing the powdery sample in container (12); supply source (14) for solvent into container (12); device (36) for heating and stirring the powdery sample and the solvent in container (12), and a control circuit for controlling the apparatus.Type: GrantFiled: December 22, 1993Date of Patent: July 25, 1995Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takashi Chino, Yuji Nogami, Hajime Yashiro, Keisuke Kato, Hajime Kitamura, Masaru Takeuchi, Hideo Yoshikoshi, Mikio Kitai
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Patent number: 5401664Abstract: A safe analytical technique for determining the concentration amount of dibutyl and monobutyl phosphate degradation products in the TBP-dodecane solvent used in solvent extraction processes. This method of chemical analysis eliminates the use of diazomethane, which is toxic and explosive, thereby providing a safer laboratory technique for routine analyses required to monitor production solvent extraction processes. The solvent sample to be analyzed is spiked with mass labelled, deuterated dibutyl and monobutyl phosphates, which act as internal standards. After adding a silylating agent, bistrimethylsilyltrifluoracetamide, the sample is injected into a gas chromatograph/mass spectrometer, which measures the ratio between the labelled internal standard and the naturally occurring material to obtain a quantitative result.Type: GrantFiled: June 10, 1993Date of Patent: March 28, 1995Assignee: General Electric CompanyInventors: Richard I. Larson, Woodfin V. Ligon, Richard L. Fox, Hans Grade
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Patent number: 5364642Abstract: The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg.sup.2+ or ionized Ca.sup.2+ and Mg.sup.2+.Type: GrantFiled: December 30, 1992Date of Patent: November 15, 1994Assignee: Research Foundation of the State University of New YorkInventors: Bella T. Altura, Burton M. Altura
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Patent number: 5344779Abstract: A method for the production of a standard oxide sample for X-ray fluorescence analysis of an impurity element contained in an inorganic compound. The standard oxide sample is produced by accurately weighing a high-purity compound of the type of the main-component element of the inorganic compound, dissolving the weighed compound in an acid, adding an element of the type of the impurity element to be subjected to determination in a prescribed amount to the acid solution, evaporating the resultant solution to dryness, and heating the dry residue of evaporation.Type: GrantFiled: March 22, 1993Date of Patent: September 6, 1994Assignee: Agency of Industrial Science & Technology, Ministry of International Trade & IndustryInventors: Keiji Kaneko, Masayuki Hirabayashi, Hideo Ihara, Hiroko Kaneko
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Patent number: 5312756Abstract: There are essentially three aspects to the present invention. In a first aspect, there is provided solid-phase calibration materials for selectively imparting predetermined inorganic or organic carbon levels to a fluid stream by dissolution, comprising solids that are sparingly and selectively soluble in the fluid stream. In a second aspect, the same materials may be used as standards for calibrating an on-line or off-line carbon analyzer at predetermined TIC and TOC levels in a fluid stream. In a third aspect, there is provided a calibration system that utilizes the standards to impart predetermined levels of selected TIC and TOC levels in a fluid sample stream. In one form of the invention, a process is provided for automatically calibrating analytical instrumentation with respect to total organic carbon and total inorganic carbon.Type: GrantFiled: December 29, 1992Date of Patent: May 17, 1994Assignee: Umpqua Research CompanyInventor: Clifford D. Jolly