With Treatment Or Replacement Of Aspirator Element (e.g., Cleaning, Etc.) Patents (Class 436/49)
  • Patent number: 9240328
    Abstract: An array of nanowires and method thereof. The array of nanowires includes a plurality of nanowires. The plurality of nanowires includes a plurality of first ends and a plurality of second ends respectively. For each of the plurality of nanowires, a corresponding first end selected from the plurality of first ends and a corresponding second end selected from the plurality of second ends are separated by a distance of at least 200 ?m. All nanowires of the plurality of nanowires are substantially parallel to each other.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: January 19, 2016
    Assignee: Alphabet Energy, Inc.
    Inventors: Mingqiang Yi, Matthew L. Scullin, Gabriel Alejandro Matus, Dawn L. Hilken, Chii Guang Lee, Sylvain Muckenhirn
  • Patent number: 9079148
    Abstract: The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface. Nucleic acid content can be transferred using a method including the steps of (a) providing a surface having one or more primer oligonucleotides attached to the surface; (b) providing a pool of beads, wherein beads in the pool have a plurality of templates attached thereto, the plurality comprising multiple copies of a single nucleic acid template sequence; (c) arraying the beads onto the surface by hybridizing the templates to the primer oligonucleotides; and (d) extending the primers to produce copies of the templates attached to the surface.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: July 14, 2015
    Assignee: Illumina Cambridge Limited
    Inventors: Roberto Rigatti, Geoffrey Paul Smith, Jonathan Mark Boutell
  • Publication number: 20150037896
    Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.
    Type: Application
    Filed: May 23, 2014
    Publication date: February 5, 2015
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb
  • Patent number: 8936944
    Abstract: A method and apparatus for managing a zone. Information is obtained about an environment in the zone with a sensor system. A determination is made by an analyzer system as to whether a contagious condition is present in the zone using the information from the sensor system. An action is performed by a management system in response to the contagious condition being present.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: January 20, 2015
    Assignee: The Boeing Company
    Inventors: Leora Peltz, Shawn Hyunsoo Park
  • Patent number: 8926903
    Abstract: To perform accurate measurement in the analysis of chemical components with low concentration, pretreatment such as concentration and purification of samples is essential. For high-throughput of pretreatment of biological samples, various random clinical testing is encountered, where analytes change from sample to sample. The pretreatment apparatus has a separating agent selectively separating a specific component by allowing a sample solution to flow therethrough. A holding section holds a plurality of housing sections, which house the separating agent therein, and has an endless track. A pressurizing section applies pressure to the housing section in a continuous and random-accessible manner; and an extraction solution receiver mechanism selectively receives an extracted solution from the separating agent housed in the housing section. A mass spectrometer is that can be connected to the pretreatment apparatus. Thus, a large number of specimens can be simultaneously processed.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: January 6, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Makoto Nogami, Katsuhiro Kanda, Izumi Waki
  • Patent number: 8918217
    Abstract: A reverse osmosis separation process is disclosed, such as for desalination and waste water reuse process, wherein an effectiveness of membrane cleaning can be estimated. Exemplary embodiments operate the reverse osmosis membrane cleaning process for a controlled time for cleaning and with a controlled value of chemical concentration in a chemical liquor prepared for cleaning the membrane. A method can include estimating fouling status of the membrane and determining a controlled value of chemical concentration in the chemical liquor, and a controlled time for cleaning based on the fouling status of the membrane.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: December 23, 2014
    Assignee: ABB Research Ltd.
    Inventors: Senthilmurugan Subbiah, Mekapati Srinivas, Naveen Bhutani
  • Patent number: 8883078
    Abstract: A sample testing system comprising: a test unit for loading and testing a sample contained in the sample container accommodated in the rack; a rack storage for storing the rack accommodating the sample container from which the sample has been loaded into the test unit; and a transporting part, configured to transport the rack in a first direction and in a second direction that is a reverse direction of the first direction, for transporting the rack in the first direction to the rack storage and transporting the rack stored in the rack storage in the second direction to a sample loading position at which the sample is loaded from the rack into the test unit, is disclosed. A transporting apparatus is also disclosed.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: November 11, 2014
    Assignee: Sysmex Corporation
    Inventors: Yuichi Hamada, Daigo Fukuma
  • Publication number: 20140302610
    Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.
    Type: Application
    Filed: May 8, 2014
    Publication date: October 9, 2014
    Inventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski
  • Publication number: 20140242706
    Abstract: To provide a specimen analyzing apparatus capable of preventing a reduction in analysis accuracy caused by contamination of a measurement sample by a substance attached to a cleaning unit, the present invention provides a blood analyzer 100 which includes a cleaning unit 7 for cleaning an aspirating tube 1 positioned within a through-hole 72, a vertical moving unit 5 for moving the aspirating tube 1 along a through-hole relative to the cleaning unit 7, and a blade 8 for removing a substance attached to the outer side of the cleaning unit 7, wherein an aspirating tube 1 is provided for aspirating a sample, a through-hole 72 is formed to allow the aspirating tube 1 to pass therethrough, and a supply path 73 is formed for supplying a cleaning liquid to the through-hole 72.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: Sysmex Corporation
    Inventors: Takahito MIHARA, Takaaki NAGAI
  • Patent number: 8788217
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: July 22, 2014
    Assignee: DAKO Denmark A/S
    Inventors: Gordon Feingold, Marc Key, John Favuzzi, Rosanne Welcher
  • Patent number: 8778686
    Abstract: Provided are an automatic analyzer which moves a dispensing apparatus having a dispensing probe, or a vessel by a driving mechanism to dispense plural liquids into the vessel via the dispensing probe, and measures and analyzes optical characteristic of a reaction liquid in which each of the dispensed liquids is reacted, and a dispensing method thereof. The automatic analyzer includes a drive controlling unit which controls the driving mechanism so that the liquid surface of the liquid and a distal end of the dispensing probe are moved relatively to each other in a vertical direction, and, when the liquids including precipitated substance are to be dispensed, the dispensing probe sucks in the liquids from plural different positions along the vertical direction.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: July 15, 2014
    Assignee: Beckman Coulter, Inc.
    Inventor: Akihisa Kuroda
  • Patent number: 8772036
    Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: July 8, 2014
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb
  • Patent number: 8758702
    Abstract: A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 24, 2014
    Assignee: Instrumentation Laboratory Company
    Inventors: Matthew Blouin, Gregory Murphy, Diana Mackenzie, Alan Weeks, Daniel Kobrenski
  • Patent number: 8709345
    Abstract: To reduce measurement time, it may be considered to quicken reaction or speed up analytic determination. In existing analyzing devices, photometry is performed, typically, about every 15 seconds, so that it has not been possible to secure satisfactory reproducibility. Namely, reducing the measurement time and securing reproducibility have not been compatible. It has therefore been desired to increase the number of times of measurements performed in a short period of time. A cell disk is controlled to stop at a position for photometry during the time after a sample and a reagent are mixed and before measurement is finished and, while the cell disk is stopped, photometry is performed once or plural times thereby increasing the total number of times of measurements.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: April 29, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Sakuichiro Adachi, Akihisa Makino
  • Patent number: 8691148
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: April 8, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Patent number: 8663397
    Abstract: The embodiments describe methods for controlling the particles generated when cleaning and drying a wafer in a spin rinse dryer (SRD) module. In some embodiments, the substrate surface is cooled by dispensing deionized (DI) water across the surface of the substrate, while the substrate rests on the SRD chuck. In addition, a method for controlling the particles generated when sleeves in a processing module or SRD contact a substrate surface during a clamping operation or when the sleeves are removed from the substrate surface is provided. A bottom edge or lip of the sleeves and/or the surface of the wafer contacting the sleeve is wetted during clamping/unclamping operations. Alternatively, the substrate may be wetted prior to clamping/unclamping operations.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 4, 2014
    Assignee: Intermolecular, Inc.
    Inventors: Satbir Kahlon, Jeffrey Chih-Hou Lowe, Frank C. Ma, Sandeep Mariserla, Robert Anthony Sculac
  • Patent number: 8623297
    Abstract: The present invention relates to a device, to a system, and to a method for the preparation and fractioned dispensing of samples of a fluid. The device of the invention comprises a body having formed therein guide means suitable for receiving a sample-taker member and for guiding it in translation through the device, and at least one preparation chamber enabling an aliquot of a fluid sample dispensed into the chamber by a said sample-taker member to be prepared in a stream of a suitable reagent. The guide means pass through the preparation chamber and communicate therewith to enable an aliquot of fluid to be dispensed into the chamber in a determined position of the sample-taker member in the guide means. The preparation chamber has an introduction orifice for introducing at least one reagent into the chamber for mixing the reagent with an aliquot, and at least one dispensing orifice for dispensing the mixture formed by said aliquot and said reagent to recovery and/or analysis means.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: January 7, 2014
    Assignee: Horiba ABX SAS
    Inventors: Roger Le Comte, Guilhem Couderc, Paul Moreno
  • Patent number: 8580574
    Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: November 12, 2013
    Assignee: Gen-Probe Incorporated
    Inventor: Robert J. Smith
  • Patent number: 8551404
    Abstract: A sample analyzer for analyzing a sample comprising: a sample container receiver capable of receiving either one of a manually supplied sample container and an automatically supplied; a container holder receiver for receiving a container holder holding at least one sample container; a sample container supplier automatically for supplying, to the sample container receiver, a sample container held by the container holder received by the container holder receiver; an aspirator for aspirating a sample within a sample container received by the sample container receiver; and an analyzing part for analyzing the sample aspirated by the aspirator.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: October 8, 2013
    Assignee: Sysmex Corporation
    Inventors: Takaaki Nagai, Mitsuo Yamasaki
  • Patent number: 8507280
    Abstract: A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: August 13, 2013
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Merrit Jacobs, Ed Graham, Karen Vavra, Chuck Noeson, Susan Danielson, Terri Fazio
  • Patent number: 8501482
    Abstract: An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing a first stain reagent and the first aliquot; a second specimen preparing section for preparing a second specimen for measuring bacteria by mixing a second stain reagent and the second aliquot; and an optical detecting section comprising a light source for irradiating a light to a specimen being supplied, a scattered light receiving element for detecting scattered light emitted from the specimen, and a fluorescence receiving element for detecting fluorescence emitted from the specimen. A method intended for use in analyzing particles in urine is also disclosed.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: August 6, 2013
    Assignee: Sysmex Corporation
    Inventors: Yousuke Tanaka, Junya Inoue, Masatsugu Ozasa, Yasuyuki Kawashima
  • Patent number: 8450114
    Abstract: Provided is an automatic analysis apparatus which can obtain stable analysis results by stabilizing a constant-temperature bath and the temperature of a reaction liquid inside reaction containers. For this purpose, the automatic analysis apparatus (1) comprises: a storage tank (10) for storing a temperature controlling liquid (L1) dispensed into reaction containers (5) using dispensing apparatuses (6) and (7); and a dispensation control section for performing a control for dispensing the temperature controlling liquid (L1) using the dispensing apparatuses into an empty reaction container when there is such an empty reaction container, in which neither a specimen nor a reagent is dispensed, on a reaction table (4), where the temperature controlling liquid is cooled down substantially equal to the dispensed reagent by laying a pipe, which is provided between a cooler and a reagent table (2) for passing the coolant, through the temperature controlling liquid in the storage tank.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: May 28, 2013
    Assignee: Beckman Coulter, Inc.
    Inventors: Masao Nichogi, Masao Ushikubo
  • Patent number: 8431079
    Abstract: Embodiments of an analyzer for performing medical diagnostic analysis of biological samples are disclosed. In one embodiment, the analyzer may have a first and at least a second disk-shaped cuvette conveyor each having an array of cuvette holders, a first drive unit for rotating the first cuvette conveyor about a rotation axis, and a second drive unit for rotating the second cuvette conveyor about the rotation axis. The operation of the second drive unit is independent from the operation of the first drive unit. The first cuvette conveyor and the second cuvette conveyor are spaced from each other in an axial direction along the rotation axis and with an air gap between them. The cuvette holders of the first cuvette conveyor and the cuvette holders of the second cuvette conveyor are adapted for holding cuvettes having the same shape and dimensions.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: April 30, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Burkard Rosenberg, Juergen Rauh
  • Patent number: 8409873
    Abstract: A method of pipetting comprises (a) providing a pipette tip holder having a plurality of segregated compartments and a tip support member for supporting a plurality of pipette tips in the pipette tip holder, the tip support member configured to support a single pipette in tip each segregated compartment; (b providing a plurality of pipette tips in the tip support member; (c) removing a first pipette tip from a first segregated compartment; (d) using the first pipette tip to complete a pipetting operation and placing the first pipette tip into a segregated compartment that has not contained a used pipette tip; (e) subsequently removing the first pipette tip from the segregated compartment and using the first pipette tip to complete another pipetting operation; and, (f) replacing the first pipette tip into the pipette tip holder, whereby the first pipette tip, when placed in the segregated compartment, is segregated in the pipette tip holder to reduce the possibility of a fluid from the first pipette tip contac
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: April 2, 2013
    Assignee: Stemcell Technologies Inc.
    Inventors: Steven Woodside, Terry Thomas, Graeme Cross, Andrew Angus
  • Patent number: 8386195
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: February 26, 2013
    Assignee: DAKO Denmark A/S
    Inventors: Gordon Feingold, Marc Key, Rosanne Welcher, John Favuzzi
  • Patent number: 8354078
    Abstract: The present invention is to present a liquid dispensing apparatus which is capable of preventing contamination by previously aspirated liquid, even when residual liquid in a pipette tip separated from the dispensing apparatus is scattered. The liquid dispensing apparatus includes: sample dispensing arm 5 which comprises a dispensing nozzle 54b for aspirating and discharging sample on which a pipette tip 200 is attached; tip separating section 140 for separating the pipette tip 200 from the dispensing nozzle 54b; and nozzle wiping section 16 for cleaning a tip of the dispensing nozzle 54b.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: January 15, 2013
    Assignee: Sysmex Corporation
    Inventors: Keiichiro Shohmi, Tomoyuki Nishida, Yoshinori Ooi
  • Patent number: 8349278
    Abstract: Apparatus (1) for withdrawing respective liquid samples from vials (2) which are closed by closure caps (4) includes a plurality of racks (7) for accommodating the vials (2). A device (10) including a housing (25) is slideably carried on a gantry (9) which in turn is slideably carried on guide tracks (12) to provide two degrees of movement of the device (10) for selective alignment of the device (10) with the vials (2). An abutment member (43) is driven vertically by a second gearwheel (51) by a drive shaft (27) through a first gearwheel (40) and a dog clutch (52). A cannula which is secured within a first gear rack (33) is driven vertically by the first gearwheel (40). On engagement of the abutment member (43) with the closure cap (4) of the selected vial (2), the clutch (52) decouples the second gearwheel (51) from the first gearwheel (40) so that the cannula (28) is urgeable through the closure cap (4) into the vial (2).
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: January 8, 2013
    Assignee: TCOAG Ireland Limited
    Inventors: Ronan Patrick O'Caoimh, James Walsh, Brendan Kevin Farrell, Rory Peter Nealon, Josef Georg Hubert Wiehe
  • Patent number: 8197754
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: June 12, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Patent number: 8198090
    Abstract: A cartridge is provided that can remove a residual liquid all around the leading end of a pipette, without requiring any new equipment, regardless of the viscosity of the residual liquid. This cartridge includes a plurality of tanks, each of which has an upper opening, and a liquid is introduced into or led out from at least one of the plurality of tanks 110 to 119 with a pipette. The cartridge further includes waste liquid tanks 120 to 122. The waste liquid tanks 120 to 122 each includes a capillary phenomenon generation portion. A residual liquid present at the leading end of the pipette is brought into contact with the capillary phenomenon generation portion of the waste liquid tanks, and the residual liquid is transferred to the capillary phenomenon generation portion through the capillary phenomenon to be removed from the pipette.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: June 12, 2012
    Assignee: ARKRAY, Inc.
    Inventors: Kosuke Kubo, Junichi Oka
  • Patent number: 8182855
    Abstract: The present invention relates to an enriched fish food product comprising a binder resin and a fermented soy nutraceutical. Optionally the nutraceutical may contain enzymes or coenzymes. Also, the enriched fish food product may be formed by mixing a resin with the fermented soy nutraceutical in a heated molding machine and subjecting said product to a variety of size reduction processes. For example, the fish food product may be provided in the form of a flake.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: May 22, 2012
    Assignee: T.F.H. Publications, Inc.
    Inventor: Glen S. Axelrod
  • Patent number: 8158060
    Abstract: A sample analyzer for analyzing a sample comprising: a sample container receiver capable of receiving either one of a manually supplied sample container and an automatically supplied; a container holder receiver for receiving a container holder holding at least one sample container; a sample container supplier automatically for supplying, to the sample container receiver, a sample container held by the container holder received by the container holder receiver; an aspirator for aspirating a sample within a sample container received by the sample container receiver; and an analyzing part for analyzing the sample aspirated by the aspirator.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: April 17, 2012
    Assignee: Sysmex Corporation
    Inventors: Takaaki Nagai, Mitsuo Yamasaki
  • Patent number: 8147778
    Abstract: A specimen container carrier for a conveyor in a laboratory automation system which includes a circular body driven by the conveyor and container holding elements arranged in the circular body, the container holding elements being maintained in a container holding position by respective elastic elements and are connected to each other by synchronization elements forcing the specimen container to remain coaxially positioned with respect to the circular body.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: April 3, 2012
    Assignee: Inpeco IP Ltd.
    Inventor: Gianandrea Pedrazzini
  • Patent number: 8142719
    Abstract: A device is disclosed, being an analysis device for the study of biological or chemical samples by means of a reagent liquid supplied via a pipette. The device has an instrument housing with a base plate, a working plate arranged on the base plate horizontally to receive the samples in a sample holder having several wells, a robot manipulator arranged above the working plate, which carries a horizontal support arm with a slide. A needle system is fastened to the slide and can move in the Z direction, carrying 3 needles and being brought into vertical positions by a first vertical drive. The needle tips can be placed in an upper position above and in a lower position below a well. The middle needle can move vertically relative to the other two needles, which can be raised and lowered by a second vertical drive. The horizontal spacing of the three needles is so small that all three needles can be positioned with their tips inside the same wells.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: March 27, 2012
    Inventors: Torsten Matthias, Hugo Ribeiro, Hans-Peter Schimon, Peter Van Praet
  • Patent number: 8080204
    Abstract: A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positioned between the sample carrier and the conveyor; advancing the sample carrier beyond the fixed registration elements; reversing the conveyor direction to back at least one of the sample carriers into contact with its corresponding registration elements; continuing to reverse the conveyor until all sample carriers are in contact with their respective registration elements; whereby the flexure elements of the sample carriers in contact with the respective registration elements will deform as the conveyor reverses to allow all sample carriers to contact their respective registration elements, thereby providing a known position of the sample carrier.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: December 20, 2011
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Dale Ryan, Johannes Porte
  • Patent number: 8012768
    Abstract: The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material that is associated with the incubation carousel for assisting in separation beads from reagent and wash solution. A robot, associated with the housing is configured to manipulate at least either the reagent carousel or the incubator carousel and transfer materials between these carousels. Reaction vessels hold samples and reaction vessels handlers move the reaction vessels. Sample analysis is determined by at least one laser based detector.
    Type: Grant
    Filed: May 1, 2007
    Date of Patent: September 6, 2011
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Nasser Jafari, Chan Patrick, Lawrence J. Blecka, Chris Tsai
  • Patent number: 7968051
    Abstract: A clinical laboratory apparatus includes a plurality of reaction cuvettes, a first dispenser, a second dispenser, a controller, and an analyzer. A subject sample and a reagent are mixed in each of the plurality of reaction cuvettes. The first dispenser is configured to dispense the subject sample into each of the plurality of reaction cuvettes. The second dispenser is configured to dispense the reagent into each of the plurality of reaction cuvettes so that the subject sample and the reagent are mixed. The controller is configured to categorize the plurality of reaction cuvettes into at least first and second groups, to designate at least first and second analysis items among two or more analysis items with respect to the subject sample, to control the second dispenser to avoid dispensing the reagent relevant to the first analysis item into the second group of the reaction cuvettes. The analyzer is configured to analyze a mixed result.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: June 28, 2011
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Takehiko Oonuma
  • Patent number: 7937228
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: May 3, 2011
    Assignee: DAKO Denmark A/S
    Inventors: Gordon Feingold, Marc Key, Rosanne Welcher, John Favuzzi
  • Patent number: 7875456
    Abstract: An automated discrete fluid sample analyzer includes a sample preparation module. The sample preparation module includes a well configured to receive a sample deposited by a pipettor and a sample preparation device in fluid communication with the well. The fluid sample is transferred from the well to the sample preparation device, and the sample preparation device prepares the fluid sample. The pipettor then aspirates the prepared fluid sample. The prepared fluid sample may be transferred from the sample preparation device back to the well, and the pipettor aspirates the prepared fluid sample from the well. In one embodiment, the sample preparation device includes a receptacle having a catalyst disposed therein. The catalyst may include a noble metal catalyst, such as cadmium. In another embodiment, the sample preparation device includes an ultraviolet lamp configured to apply ultraviolet light to the fluid sample.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: January 25, 2011
    Assignee: WESTCO Scientific Instruments, Inc.
    Inventors: Joseph Platano, Antonio Gagliarducci, Ausilio Pieralisi
  • Patent number: 7875241
    Abstract: Provided is a specimen preparation apparatus capable of supplying a specimen from the specimen preparation apparatus to a specimen analyzer without burdening an operator. This specimen preparation apparatus comprises a stained specimen preparation part for preparing a specimen on a slide glass and staining the specimen, a keeping part for storing the stained specimen slide glass prepared in the stained specimen preparation part and a control part for deciding whether to supply the stained specimen slide glass to the keeping part or to the external apparatus.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: January 25, 2011
    Assignee: Sysmex Corporation
    Inventor: Masanori Nakaya
  • Patent number: 7875463
    Abstract: A generalized printhead control model is provided herein as a basis for configuring printhead control software that will operate any selected printhead or group of printheads. The subject model covers a hierarchy of classes for the attributes of software that controls the printheads in a system, such as for producing a biopolymer array.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: January 25, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: David R. Adaskin, Bill J. Peck, Stanley P. Woods, William G. Chesk
  • Patent number: 7867768
    Abstract: A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positioned between the sample carrier and the conveyor; advancing the sample carrier beyond the fixed registration elements; reversing the conveyor direction to back at least one of the sample carriers into contact with its corresponding registration elements; continuing to reverse the conveyor until all sample carriers are in contact with their respective registration elements; whereby the flexure elements of the sample carriers in contact with the respective registration elements will deform as the conveyor reverses to allow all sample carriers to contact their respective registration elements, thereby providing a known position of the sample carrier.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: January 11, 2011
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Dale Ryan, Johannes Porte
  • Patent number: 7858040
    Abstract: A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: December 28, 2010
    Assignee: Saryna Biotechnologies LLC
    Inventors: Alex Okun, Teresa A. Bennett, Andrew Beernink, David J. Sieg, John T. Ransom
  • Patent number: 7858032
    Abstract: A device including a pre-analytical module provided with at least one tube stirrer for homogenizing blood and preventing clot formation and disposed on a line for single-tube transfer between an area for storing analyzable tubes, and at least one unitary operating whole blood analyzer and automatic tube-loading/unloading device arranged between the tube stirrer and the single-tube transfer line. The device is suitable for blood analyzers.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: December 28, 2010
    Assignee: Horiba ABX SAS
    Inventors: Roger Le Comte, François Dupoteau
  • Patent number: 7855077
    Abstract: An automated analyzer is configured to receive and analyze samples provided to the automated analyzer in primary sample containers. The automated analyzer comprises a sample retention unit, at least one transport device, and at least one aspiration device. The sample retention unit is configured to receive and retain a plurality of sample retention vessels. The sample retention unit may comprise a sample storage unit, an analytic unit, or other processing unit within the automated analyzer that retains a sample for some purpose. The transport device is configured to receive a first primary sample container containing a first sample and deliver the first primary sample container to the sample retention unit as one of the plurality of sample retention vessels. The aspiration device is configured to receive a second sample from a second primary sample container and deliver the second sample into one of the plurality of sample retention vessels.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: December 21, 2010
    Assignee: Beckman Coulter, Inc.
    Inventor: Brian D. Wilson
  • Patent number: 7854892
    Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: December 21, 2010
    Assignee: Beckman Coulter, Inc.
    Inventors: Craig R. Veiner, Frank M. Tappen, Roberto Del Valle
  • Patent number: 7850914
    Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: December 14, 2010
    Assignee: Beckman Coulter, Inc.
    Inventors: Craig R. Veiner, Frank M. Tappen, Roberto Del Valle
  • Patent number: 7824915
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: November 2, 2010
    Assignee: Hitachi, Ltd.
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Patent number: 7802437
    Abstract: The electronic component with heat transfer by boiling and condensation comprises heat exchange surfaces immersed in a heat conducting fluid constituted by the free ends of nanowires of a thermoelectric converter. An electrically insulating coating material with a low thermal conduction partially covers the nanowires above the heat conducting fluid. Each nanowire forms a thermocouple composed of two coaxial branches made from materials of different natures separated by a layer of electrically insulating material and electrically connected individually to the free end of the nanowire.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: September 28, 2010
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Jean-Antoine Gruss, Marc Plissonnier
  • Patent number: 7803626
    Abstract: An automatic analyzer is for analyzing a reaction liquid in which a specimen and a reagent have been reacted. The automatic analyzer includes a dispensing system, a detector, and a determiner. The dispensing system includes a dispensing nozzle by which the specimen and the reagent are dispensed; and a dispensing pipe connected to the dispensing nozzle and filled with a cleaning liquid. The dispensing nozzle is cleaned with the cleaning liquid discharged from the dispensing nozzle. The detector detects a discharge amount of the cleaning liquid discharged from the dispensing nozzle. The determiner determines whether the detected discharge amount of the cleaning liquid is over a predetermined value which is less than a pre-set discharge amount of the cleaning liquid. The determiner determines that the dispensing is abnormal if the detected discharge amount is equal to or less than the predetermined value.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: September 28, 2010
    Assignee: Beckman Coulter, Inc.
    Inventor: Akihisa Kuroda
  • Patent number: 7794660
    Abstract: A fluid content monitor including a cuvette, a calorimeter adapted to generate a signal indicative of contents of a fluid sample contained in the cuvette, a container for holding a reagent, and a pump assembly for delivering reagent from the container to the cuvette. The pump assembly includes a tube extending from the container to the cuvette, check valves preventing reverse flow in the tube, and a hammer driven by a solenoid for repetitively compressing the tube to pump reagent to the cuvette. The cuvette can be removed for cleaning and replacement.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: September 14, 2010
    Assignee: HF Scientific, Inc.
    Inventors: Rowan Connelly, Joel Leal