Automated Chemical Analysis Patents (Class 436/43)
  • Patent number: 10274428
    Abstract: Disclosed is apparatus (1) for measuring fluorescence and absorbance of a substance in a sample, said apparatus (1) comprising: a flow cell (2) for containing a sample, a first light source (3), a first conductor (5) for transmitting light from the first light source (3) to the flow cell (2) for irradiating a sample contained therein, a second conductor (7) for transmitting light from the flow cell (2) to a sample detector (9) arranged to detect an electromagnetic radiation that has passed through said cell (2), and a processing unit (16) arranged to receive a first signal (31) from a reference detector (15) and a second signal (32) from the sample detector (9) and to determine an absorbance based on said first and second signals (31,32), said apparatus (1) further comprising a second light source (4), a third conductor (6) for transmitting light from the second light source (4) to the cell (2) and wherein the sample detector (9) is further arranged to also detect fluorescence signals in the light that has pa
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 30, 2019
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Hanno Ehring
  • Patent number: 10267816
    Abstract: An automatic analysis device has a structure that allows the operator to add or replace a reagent. A reagent container loading portion has an opening through which a reagent container is adapted to be introduced into the device. A reagent container transport tool has a plurality of reagent container insertion slots and is movable up and down. A refrigerator to cool a plurality of reagent containers has an opening that allows the reagent container transport tool to pass therethrough. An elevating and lowering mechanism is configured to elevate or lower the reagent container transport tool. A reagent container loading portion has a plurality of guide grooves arranged radially on its lower surface in front of the opening that are adapted to guide a reagent container. The guide grooves communicate with the respective reagent container insertion slots arranged radially on the reagent container transport tool at an elevated position.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: April 23, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Mitsuru Oonuma, Hiroyuki Noda, Katsuhiro Kambara, Hiroaki Sakai
  • Patent number: 10261141
    Abstract: Selection-focus coils de-signed for 3D FFL-based MPI may allow for spatial encoding without additional shift coils and provide relatively large FOV and field gradient with very flat FFL. Additionally, a single-sided FFL-based device which is capable of 3D imaging is disclosed. With sufficient current amplitudes, FFL could encode the whole volume of a small animal or penetrate deep into human organs such as the vascular system or lymph nodes. An MPI device based on the proposed selection scheme could be a compact and robust alternative to the state-of-the-art FFP (FFL)-based MPI scanners.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 16, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventor: Alexey Tonyushkin
  • Patent number: 10247744
    Abstract: A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 2, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thomas Meyer, Gottlieb Schacher, Rolf Sigrist, Christian Guzek
  • Patent number: 10226770
    Abstract: A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a thermal chuck in thermal communication with the heating element. The thermal chuck comprises a heating surface operable to make thermal contact with the microfluidic device. The heating surface is characterized by a temperature ramp rate between 2.5 degrees Celsius per second and 5.5 degrees Celsius per second and a temperature difference between a first portion of the heating surface supporting a first portion of the microfluidic device and a second portion of the heating surface supporting a second portion of the microfluidic device is less than 0.25° C.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: March 12, 2019
    Assignee: Fluidigm Corporation
    Inventors: Jake Kimball, Brandon Ripley, Gang Sun, Dominique Toppani, Myo Thu Maung
  • Patent number: 10139292
    Abstract: The invention relates to a calorimeter including at least one measurement sensor (4) for receiving at least one sample, and at least three stages (1, 2, 3) for controlling the temperature, with decreasing size, each including a mounting (10, 20, 30) and means for controlling the temperature, the smallest stage being associated with said at least one sensor (4), in which: a first stage (1) also includes a screen (11) forming a first enclosure with the mounting (10) of said first stage; a second stage (2) is placed inside (12) said first enclosure and the mounting (20) thereof is thermally coupled with the mounting (10) of the first stage by first thermal conductances (23) comprising Peltier elements; and a third stage (3) is placed inside the second enclosure defined by the second stage and is thermally coupled with said second stage (2) by second passive thermal conductances (33) defining an adapted time-constant value.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: November 27, 2018
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Luc Garden, Pierre Brosse-Maron, Gaël Moiroux
  • Patent number: 10139343
    Abstract: A fluorescence and/or chemiluminescence measuring device and method, able to achieve a series of actions synchronously including placing reaction cup, injection, extraction, reading, releasing reaction cup and light block, and no extra arm for getting and releasing reaction cup is needed. A sliding cartridge drives the reaction cup to perform movement to achieve the actions above in turn. Moreover, it maximally ensures a consistence of distance and relative height between each reaction cup and the reading photomultiplier device, so as the operation speed is faster and easier.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: November 27, 2018
    Assignee: Technogenetics Holdings S.r.l.
    Inventors: Chao Yu, Jianbo Tang, Shenguang Su, Qingwen Tang, Luca Melillo
  • Patent number: 10126286
    Abstract: A lance and a method determine reaction data of the course of a reaction, in which a reaction gas is top-blown by at least one lance onto a metallic melt in a metallurgical vessel and measured data are determined in this way, reaction data for the course of the reaction are determined as a function of these, where the lance for determining measured data blows out a gas which is conveyed separately from the reaction gas through at least one outlet opening of at least one measuring conduit. The lance for determining measured data blows out the gas which is conveyed separately from the reaction gas laterally through at least one outlet opening of at least one measuring conduit and the internal pressure of at least one gas bubble of this gas formed at this outlet opening of the respective measuring conduit is measured.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 13, 2018
    Assignee: VOESTALPINE STAHL GMBH
    Inventors: Stefan Schuster, Gunter Lengauer, Harald Panhofer
  • Patent number: 10092899
    Abstract: This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A measuring system is provided having: a base unit with a means for locating a pipette tip; a pipette tip designed to interact with the base unit for purposes of accurate pipette tip positioning; at least one light supplying unit positioned to supply light to a liquid sample in the pipette tip and at least one light collecting unit positioned to collect light from a liquid sample in the pipette tip.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: October 9, 2018
    Assignee: Beacon Technologies, LLC
    Inventor: Dale Lee Heintzelman
  • Patent number: 10081503
    Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 25, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Markus Rinderknecht
  • Patent number: 10072640
    Abstract: A driving device of a micropump and a microvalve is provided. The driving device comprises a pump driver controlled by a pump controller, a valve driver controlled by a valve controller, a power supply part, a switch part. The pump driver having a first shape memory alloy wire, a micropump of the first shape memory alloy wire, a wiring part arranged in parallel to the first shape memory alloy wire, and a first selector switch that switches between a state where only the first shape memory alloy wire is energizable and a state where the wiring part is energizable. The valve driver having a plurality of second shape memory alloy wires, a plurality of microvalves of second shape memory alloy wires, and a second selector switch that brings into a state where one of the plurality of second shape memory alloy wires is energizable.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: September 11, 2018
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventor: Katsuhiko Asai
  • Patent number: 10036065
    Abstract: An analysis apparatus for performing biochemical analysis of a sample using nanopores comprises: a sensor device that that supports plural nanopores, reservoirs holding material for performing the analysis; a fluidics system; and plural containers for receiving respective samples, all arranged in a cartridge that is removably attachable to an electronics unit arranged to generate drive signals to perform signal processing circuit to generate output data representing the results of the analysis. The fluidics system supplies samples selectively from the containers to the sensor device using a rotary valve. In one valve, a stator defines a plurality of first ports arranged around the rotational axis and a collection chamber extending in around the axis of rotation in communication with a second port. A rotor provides a passage extending between the collection chamber and a position in communication with any one of the plurality of first ports.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: July 31, 2018
    Assignee: Oxford Nanopore Technologies Limited
    Inventor: Anthony Jones
  • Patent number: 10031085
    Abstract: A point of care testing system includes a reader having an incubator disposed within a reader housing, the incubator having a rotor supported for rotation and having a plurality of circumferentially disposed slots. A drive mechanism is configured to rotate the rotor about a center axis A plurality of analytical test elements are sized for fitting in the slots of the incubator either manually or on demand. Each analytical test element commonly includes a support within a cartridge. The support retains at least one of a dry chemistry chip comprising a porous spreading layer disposed in stacked relation with at least one reagent layer or a lateral flow assay device wherein the plurality of test elements can assume a common form factor with multiplexed capability, and in which cartridges are preferably gated to enable random access processing.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: July 24, 2018
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventor: Raymond F. Jakubowicz
  • Patent number: 10031120
    Abstract: A wipe for detecting the presence of an explosive substance is composed of an absorbent or adsorbent substrate and a chemical detection solution impregnated within the substrate. The chemical detection solution includes a redox color indicating agent that is operable to exhibit a color change upon reacting with the explosive substance.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: July 24, 2018
    Assignee: Trace Eye-D, LLC
    Inventor: Bernard Gorski
  • Patent number: 10005574
    Abstract: A method and a device for handling test tubes in a laboratory automation system are presented. During the handling, an open end of the test tube is covered by a residue-free removable, flat cover element forced against the open end of the test tube.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: June 26, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Lech Margner
  • Patent number: 9983221
    Abstract: A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: May 29, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thomas Meyer, Gottlieb Schacher, Rolf Sigrist, Christian Guzek
  • Patent number: 9927449
    Abstract: A liquid analysis system for a photometric determination of an analyte in a liquid sample includes an analyzer comprising a photometer, an RFID parameter reading device and an identifier reading device, and a cuvette package comprising an RFID parameter transponder and a plurality of test cuvettes of one batch. Each test cuvette comprises a reagent. Batch identification and batch-specific reagent data are stored in the RFID parameter transponder. Each test cuvette comprises a batch-specific identifier including a batch identification. The batch identification is configured to be read by the identifier reading device.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: March 27, 2018
    Assignee: HACH LANCE GMBH
    Inventors: Gabriel Rueeck, Helga Guthmann, Johannes Berssen, Michael Ziedrich, Carsten Schulz, Clemens Hanschke, Florens Engel, Dietmar Zangenberg, Markus Lenhard, Thomas Coeper
  • Patent number: 9857347
    Abstract: An automated dispersive liquid-liquid microextraction method of detecting and quantifying N-nitrosamines in an aqueous sample. The method includes (a) extracting an aqueous solution including the N-nitrosamines by mixing an extraction solvent and a dispersive solvent with the aqueous solution, such that the N-nitrosamines, or a portion thereof, re-distribute from the aqueous solution to the extraction solvent, (b) permitting the resulting mixture in (a) to form a two-phase mixture containing an aqueous phase containing the aqueous solution with reduced amounts of the N-nitrosamines and an organic phase including the extraction solvent with the N-nitrosamines extracted from the aqueous solution, (c) injecting the organic phase, or a portion thereof, into an injection port of a gas chromatograph coupled with at least one mass spectrometer, and (d) analyzing the N-nitrosamines by gas chromatography and mass spectrometry to detect and quantify the concentration of the N-nitrosamines in the aqueous solution.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: January 2, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Chanbasha Basheer, Mousa Yaser Amayreh
  • Patent number: 9835528
    Abstract: A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each of a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device and may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: December 5, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: William Alan Fox, Ryan Carl Williams, Brian Reuben Langhoff
  • Patent number: 9810704
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: November 7, 2017
    Assignee: Theranos, Inc.
    Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Joy Roy, Timothy Smith, Daniel Young
  • Patent number: 9759705
    Abstract: An automated dispersive liquid-liquid microextraction method of detecting and quanta N-nitrosamines in an aqueous sample.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: September 12, 2017
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Chanbasha Basheer, Mousa Yaser Amayreh
  • Patent number: 9733157
    Abstract: The present invention provides an automatic blood-sampling tube preparation system which can reduce the reading mistake of the information of the RFID tags by selectively taking out a blood-sampling tube required to an examination of a patient according to a doctor's instruction information from the blood-sampling tube containing section, writing the patient examination information on a RFID tag of the taken out tube on the basis of the instruction information, reading simultaneously all patient examination information from all RFID tags contained in the prepared container for every patient, and comparing the information read from the RFID tags with the instruction information to ensure accuracy.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: August 15, 2017
    Assignee: TECHNO MEDICA CO., LTD.
    Inventors: Toshikazu Matsumoto, Yoshimi Hirasawa, Yasushi Nakano, Yusuke Wada, Ichiro Nakamura
  • Patent number: 9695456
    Abstract: A solution is the microorganism testing apparatus equipped with a pre-processing unit in which, if a content of microorganism testing on a specific specimen is selected or input, testing conditions of the specimen read from a storage device in which testing information specifying the testing conditions of the specimen is stored are printed on a sheet-form medium to be used for testing of the specimen, and a post-processing unit in which, if an image of the medium is read, the testing conditions printed on the medium and a type of the medium preliminarily labelled on the medium are acquired from the image to output judgment results as to whether or not the testing conditions acquired from the image, and the type of the medium are compatible.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: July 4, 2017
    Assignee: JNC CORPORATION
    Inventors: Hajime Teramura, Hiromi Osawa, Ryuzo Kimura, Ikuo Sato
  • Patent number: 9678094
    Abstract: The invention relates to apparatus for determining the position of an automatically displaceable gauge. The apparatus comprises the gauge, a first device for displacing the gauge in the spatial X-direction, a second device for displacing the gauge in a spatial Z-direction, a sensor for identifying the abutment of the gauge on, or the approach thereof to, an article, an at least partly bordered receptacle position, into which the gauge is at least partly insertable by displacing the gauge in the spatial X- and/or Z-direction, and a movable assembly, wherein the receptacle position for the gauge is arranged on the movable assembly.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 13, 2017
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventors: Carolin Brade, Dirk Bugner, Guenther Kotulla
  • Patent number: 9656266
    Abstract: A diagnostic system with a handling system that has a loading bay to receive and hold a plurality of carriers. An identification device is configured to identify an identifying feature of the carriers to determine the type of contents loaded on each carrier. A transporter transports the carriers from the loading bay to a first or second location depending on the determined type of contents on each carrier. The transporter has random access to the plurality of carriers in the loading bay. A diagnostic process is conducted using the contents. A carrier, such a for reagents, has one or more holding portions, at least one of which can be moved or rotated with respect to the body of the carrier for mixing or stirring the contents of a container coupled therewith. Also, a retention member can be associated with a positioning device, such as a carousel, to lock and unlock the carrier with respect thereto.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 23, 2017
    Assignee: Abbott Laboratories
    Inventor: Robert Paul Luoma, II
  • Patent number: 9638610
    Abstract: Disclosed is a sample processing apparatus that comprises a rack with positions to hold sample tubes, the rack including a rack identification suited to a kind of sample tube, a rack set unit that accepts the rack in a detachable manner, a tube transfer unit with mechanical movement to grab and take out each sample tube from a rack held in the rack set unit, a rack detector comprising a sensor to detect the rack identification of the rack held in the rack set unit, and a controller that controls movement of the tube transfer unit based on a detection result of the rack detector.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: May 2, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Daigo Fukuma, Mitsuo Yamasaki, Noriyuki Nakanishi, Syunsuke Yao
  • Patent number: 9638709
    Abstract: This analysis apparatus includes a transporter transporting the specimens to the first measurement unit and the second measurement unit, and a control portion so controlling the transporter as to transport a first specimen container, stored in the rack, storing a first specimen to the first measurement unit and as to transport a second specimen container, stored in the rack along with the first specimen container, storing a second specimen to the second measurement unit.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 2, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Yuichi Hamada, Masaharu Shibata
  • Patent number: 9605298
    Abstract: Systems and methods are provided for high speed sorting of objects in a continuous body of fluid. The object can be analyzed within one or more interrogation volumes that allow for simultaneous or time-correlated measurement of the object's properties. A processor can interpret the properties of the object and then measured and then direct the object to one of a plurality of downstream flow paths. In some embodiments, the sorting of the object is based on two or more properties of the object. The sorting process can be repeated to create a network of sorting events.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: March 28, 2017
    Assignee: Cornell University
    Inventors: Harold G. Craighead, Benjamin R. Cipriany, Stephen Levy, Paul Soloway
  • Patent number: 9586204
    Abstract: The present disclosure proposes a design of a biomedical paper sensor which can determine the concentration of biological materials in fluids such as blood, urine, and saliva. The sensor contains a plurality of axially radiating test zones, each test zone separated from other test zones by wax ink barriers formed by a process that produces thin walls. Each test zone can contain a unique test reagent, or a unique concentration of a test reagent, and can also be identified by printed text. The region of the device outside of the test zone area is printed with a uniform reference color. Benefits of the invention include increased accuracy in the measurement of the concentration of biological materials due to the larger test zone area. Benefits also include the integration of the reference or calibration color which simplifies the calibration needed for quantification of the concentration.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: March 7, 2017
    Assignee: Xerox Corporation
    Inventors: Wei Hong, Jing Zhou, Mandakini Kanungo, Xing Liu, Nancy Y. Jia, Sarah J. Vella, Laura Lu
  • Patent number: 9453790
    Abstract: A blood analyzer comprising: a specimen preparation section for preparing a measurement specimen that is used to measure a white blood cell count among CBC measurement items; a measurement section for obtaining optical information from blood cells contained in the measurement specimen; and a controller carrying out operations comprising: classifying blood cells contained in the measurement specimen into at least white blood cells and blood cells suspected to be abnormal blood cells based on the optical information; obtaining distribution data of the white blood cells and distribution data of the blood cells suspected to be abnormal blood cells; counting the white blood cells based on the distribution data of the white blood cells; and determining presence or absence of the abnormal blood cells in the blood sample, based on the distribution data of the blood cells suspected to be abnormal blood cells. A blood analyzing method and a computer program product are also disclosed.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: September 27, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Ayumu Yoshida, Shinichiro Oguni, Tatsuya Narikawa, Saori Suzuki
  • Patent number: 9395380
    Abstract: A specimen processing apparatus comprising: a specimen processing section which includes a movable section and processes a specimen by moving the movable section; and a controller for determining whether the movable section was moved while a specimen processing operation by the specimen processing section was stopped, and controlling the specimen processing section to perform a preparing operation for starting the specimen processing operation based on the determination result, is disclosed. A control method for a specimen processing apparatus is also disclosed.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: July 19, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Takashi Yamato, Hiroshi Kurono
  • Patent number: 9360466
    Abstract: A total organic carbon meter including a sample introduction mechanism that includes a case in which a sample introduction and rod opening is formed; a sample introduction rod at the front end part of which a sample tray is arranged and which is inserted in the set direction through the sample introduction and rod opening; and a cover formed on the outer circumferential surface of the sample introduction rod, wherein the insertion of the sample introduction rod, on the front end part of which a sample tray has been arranged, through the sample introduction and rod opening, causes the gap between the sample introduction and rod opening and the sample introduction rod to be closed by the cover.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: June 7, 2016
    Assignee: SHIMADZU CORPORATION
    Inventor: Takeshi Iharada
  • Patent number: 9297820
    Abstract: An automatic analyzer includes a storage unit for storing operation information information about usage histories of expendable supplies provided for the analysis, and an analysis-ID control unit giving an ID to the analysis, the analysis ID being used as information for identifying the analysis to derive a calibration curve. Data stored in the storage unit is organized along the same time axis both in the order of samples subjected to the analysis and inspection, and in the order of analysis items, so that the data is output in a total data display area. The data is organized from the viewpoint of an analysis process of an analysis item of each sample. By use of information used to identify an influence range based on a kind of an abnormal state, which is stored beforehand, a judgment is made as to whether or not it is necessary to perform reinspection.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: March 29, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Noriko Iizumi, Tomoko Tomiyama, Yoshimitsu Takagi, Kyoko Imai, Ryuichiro Kodama, Tomonori Mimura
  • Patent number: 9278351
    Abstract: A system for measuring asphaltene content of crude oil, includes a microfluidic chip, the microfluidic chip having a crude oil sample inlet port, a solvent port, a mixer and reactor section in fluid communication with the crude oil sample inlet port and the solvent port, and a filter in fluid communication with the mixer and reactor section, the filter having an inlet side and an outlet side, a waste port in fluid communication with the inlet side of the filter, and a product port in fluid communication with the outlet side of the filter. The system further includes an optical cell in fluid communication with the product port.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: March 8, 2016
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Farshid Mostowfi, Abdel M. Kharrat, Philip James Homewood, Joseph Samuel Baddeley, Marc Schneider
  • Patent number: 9256935
    Abstract: A gripping element may be commanded to move to pre-determined robot-frame locations, and markings may be punched into a calibration sample capture substrate at each location. A calibration image may be obtained, and fiducial markings on the gripping element may be detected. A set of calibration regions of interest may be predicted, and the previously punched markings may be detected. A sampling system may then create a mapping transfer function between detected image locations and real-world locations resulting from the commanded locations of the gripping element when the markings were punched. An indication may subsequently be received that a biological sample capture substrate is ready to be processed. An image of the sample capture substrate may be obtained, and the fiducial markings may be detected. Based on those image locations and the mapping transfer function, biological sample portions may be automatically taken from the sample capture substrate.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: February 9, 2016
    Assignee: General Electric Company
    Inventors: Pierino Gianni Bonanni, Weston B. Griffin
  • Patent number: 9218934
    Abstract: The disclosure relates to a method of operating a gas field ion beam system in which the gas field ion beam system comprises an external housing, an internal housing, arranged within the external housing, an electrically conductive tip arranged within the internal housing, a gas supply for supplying one or more gases to the internal housing, the gas supply having a tube terminating within the internal housing, and an extractor electrode having a hole to permit ions generated in the neighborhood of the tip to pass through the hole into the external housing. The method comprises the step of regularly heating the external housing, the internal housing, the electrically conductive tip, the tube and the extractor electrode to a temperature of above 100° C.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: December 22, 2015
    Assignee: Carl Zeiss Microscopy, LLC
    Inventors: John A. Notte, IV, Weijie Huang, FHM-Faridur Rahman, Shawn McVey
  • Patent number: 9205425
    Abstract: Disclosed is real-time monitoring apparatus comprising a thermal cycling reaction block having heating block which is formed of a hollow part and divided by an insulating layer, and a capillary tube through which a sample is flowed in and/or out and which is wound on the heating block so that the different temperatures are transferred and thus reaction cycle is repeatedly performed; a light source; a band pass filter; a condensing lens; a beam splitter; a reflecting mirror which is rotatably connected with a motor so as to transfer the excitation light reflected from the beam splitter to the capillary tube and reflect the fluorescence generated from the sample in the capillary tube; and a fluorescence detecting part.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: December 8, 2015
    Assignee: BIONEER CORPORATION
    Inventors: Han Oh Park, Hanee Park, Il Kyu Choi
  • Patent number: 9207159
    Abstract: A particle analyzer may include a sampling unit configured to collect samples containing particles; a sample preparing unit configured to prepare different sub-samples; a reaction unit configured to incubate the sub-samples and one or more corresponding reagents respectively and provide them to the injecting unit; an injecting unit configured to inject the sub-samples to the optical unit; an optical unit configured to irradiate the sub-samples to obtain particle information; a processing unit configured to process and output the particle information; and a threshold value unit configured to compare a total number of particles with a pre-determined threshold value and to output a result of the comparison to the injecting unit to control subsequent injection of one or more sub-samples.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: December 8, 2015
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Wenheng Guo, Jin Teng, Yingjian Zhan, Shuang Zhou, Huilin Shi
  • Patent number: 9176137
    Abstract: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: November 3, 2015
    Assignee: California Institute of Technology
    Inventors: Stephen R. Quake, Marc A. Unger, Hou-Pu Chou, Todd A. Thorsen, Axel Scherer
  • Patent number: 9170227
    Abstract: The invention discloses a system for the simultaneous detection and/or quantification of various analytes in a sample or for the simultaneous detection and/or quantification of an analyte in various samples, comprising: a multi-electrode chip (10) comprising an array of microelectrodes (11a, 11b, 11c, 11d); a single-duct cell (20), comprising a groove (21) which accommodates the multi-electrode chip (10) and a duct (22) through which a fluid sample can sequentially flow through each of the microelectrodes (11a, 11b, 11c, 11d) of a multi-electrode chip (10) when the latter is inserted into the groove (21); and a multi-duct cell (30), comprising a groove (31) housing the multi-electrode chip (10) and several independent ducts (32a, 32b, 32c, 32d) through which several samples can pass independently through each electrode (11a, 11b, 11c, 11d) of the multi-electrode chip (10).
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: October 27, 2015
    Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
    Inventors: Javier Ramón Azcón, Francisco José Sánchez Baeza, María Pilar Marco Colas, Andrei Bratov Nikiforov, Natalia Abramova, Andrey Ipatov
  • Patent number: 9164110
    Abstract: A sample processing apparatus is disclosed. The apparatus comprises a sample processing section configured to perform a process on a sample; and a controller configured to execute an order defining a process to be performed on a sample and to cause the sample processing section to perform the process on the sample according to the order. When the controller receives an instruction to perform a shutdown operation, the controller performs the following operations comprising: prohibiting the execution of the shutdown operation if an unexecuted order remains; and causing the sample processing section to perform the shutdown operation if there is no unexecuted order.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 20, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Daigo Fukuma, Tetsuya Kaneko, Osamu Hirota
  • Patent number: 9145590
    Abstract: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: September 29, 2015
    Assignee: XY, LLC
    Inventors: Kenneth M. Evans, Erik B. van Munster
  • Patent number: 9140632
    Abstract: A method for handling a sample tube containing a biological sample is presented. A tube label can be attached to the sample tube. The tube label can carry tube data. The tube data can comprise at least geometric tube data descriptive of at least one geometric property of the sample tube. At least the geometric tube data can be read from the tube label by a reader device. At least the geometric tube data from the reader device can be transmitted to a processing device. The processing device for handling the sample tube can be controlled in accordance with the at least one geometric property described by the read geometric data.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: September 22, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Frederic Furrer
  • Patent number: 9096885
    Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: August 4, 2015
    Assignee: Beckman Coulter, Inc.
    Inventors: Patricio Vidal, Christophe Godefroy, Phaisit Chewputtanagul, Jiuliu Lu
  • Patent number: 9097704
    Abstract: A method whereby one or more fluorescent dyes are used to bind and stain nucleic acids in certain blood cells, such as, for example, white blood cells, nucleated red blood cells, and reticulocytes, and to induce fluorescent emissions upon excitation of photons from a given source of light, such as, for example, a laser, at an appropriate wavelength. More particularly, this invention provides a method whereby a fluorescent trigger is used in a data collection step for collecting events that emit strong fluorescence, in order to separate white blood cells and nucleated red blood cells from red blood cells and platelets without the need for using a lysing agent.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: August 4, 2015
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Giacomo Vacca
  • Patent number: 9091624
    Abstract: Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (WBC) differential analysis. The systems and methods screen WBCs by means of fluorescence staining and a fluorescence triggering strategy. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder WBC reagent(s), suitable for assays of samples containing fragile WBCs. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye, which corresponds in emission spectrum to an excitation source of a hematology instrument; (b) using a fluorescence trigger to screen the blood sample for WBCs; and (c) using measurements of (1) axial light loss, (2) intermediate angle scatter, (3) 90° polarized side scatter, (4) 90° depolarized side scatter, and (5) fluorescence emission to perform a differentiation analysis.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: July 28, 2015
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Giacomo Vacca
  • Patent number: 9092557
    Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: July 28, 2015
    Assignee: Bayer HealthCare LLC
    Inventor: Kevin Chang
  • Patent number: 9086417
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: July 21, 2015
    Assignee: CUE INC.
    Inventors: Ayub Khattak, Clinton Sever
  • Patent number: 9047545
    Abstract: A chemistry analyzer is disclosed that can include a unitary base with vertical and horizontal supports for constraining subassemblies. The subassemblies include at least a reagent/sample carousel subassembly, a transfer arm subassembly, and a reaction carousel subassembly. A centralized hydraulic system can also be provided behind a user access panel. The analyzer can use machine-readable test specifications coupled with its reagent vessels to define tests that include operations that employ the reagents. The analyzer can also display to the operator a pictorial representation that includes graphical elements that convey levels of usage for the storage vessels, and access icons that are each associated with a color and each lead to a set of screens for different types of operations for the analyzer.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: June 2, 2015
    Assignee: Medica Corporation
    Inventors: Jeannine Dussi, Edward Ganshirt, Ray Goodwin, Stan Liffman, Tony Mao, Doug Moe, Steve Rettew, Ian Smith, Charlene Soley, Le Nguyen, Qian Sun, Will Whelan, Diana Zipeto, Gregg Sweetser
  • Patent number: 9040303
    Abstract: An apparatus for measuring a volume of fluid includes at least one emitter configured to project a signal toward a predetermined position of a sample container, at least one receiver configured to receive the signal after the signal interacts with the sample container and a fluid transfer device in communication with the receiver and sample container. A change in the signal received by the receiver indicates when the fluid has dropped below the predetermined position. The apparatus determines a volume of fluid that the fluid transfer device has removed from the sample container when the receiver detects that the fluid has dropped below the predetermined position.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 26, 2015
    Assignee: Argos Therapeutics, Inc.
    Inventors: Simon Jonathon Spence, Richard Alexander Grant