Tracers Or Tags Patents (Class 436/56)
  • Patent number: 10506949
    Abstract: A device determines drug/alcohol content level in the breath of a person (1) with a stationary monitoring device (2), a communication unit (5) for data transmission to a central computer unit (4) and a hand-held device (3), connected via a data interface (6). The hand-held device has a mouthpiece (7) to receive a breath sample in a sample-receiving unit (18). An analysis unit (8) determines and transmits a drug/alcohol level via the data interface (6) to the monitoring device (2). A camera unit (16) records a skin area (13) of the person (1). An identification unit (9) makes a comparison of a recognized pattern on the skin with a pattern stored in a memory and a control signal is generated in case a pattern deviation. A control (10) is configured to transmit image data and/or a violation of the rules for performing the test if a limit value is exceeded.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: December 17, 2019
    Assignee: Dräger Safety AG & Co. KGaA
    Inventor: Doreen Gimbel
  • Patent number: 10145855
    Abstract: Provided herein are methods and dose packs for the monitoring of medication adherence. In one aspect, the dose pack comprises comprise a multiplicity of doses of an agent and a multiplicity of doses of a marker and be configured to isolate a pair of at least one of the multiplicity of doses of the agent and at least one of the multiplicity of doses of the marker for co-administration of the pair to the subject according to the dosing schedule. In another aspect, the method comprises obtaining a sample from the subject subsequent to the conclusion of a monitoring window and analyzing the sample for the presence or absence of a marker or a degradation product thereof.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: December 4, 2018
    Assignee: Synapse Biosciences, LLC
    Inventors: Robert Anthony Millet, Jr., Philip T. Radford, Ashwin Anand Patkar
  • Patent number: 9913616
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: March 13, 2018
    Assignee: HeartFlow, Inc.
    Inventors: Timothy A. Fonte, Charles A. Taylor, Hyun Jin Kim, Sophie Khem
  • Patent number: 9872117
    Abstract: A device and method for adjusting an output to an audio port based on a determined sensitivity is provided. The device comprises a processor, an audio port, and an electrical measurement device configured to measure electrical properties of an external device plugged into the audio port over a range of frequencies. Using the electrical measurement device, one or more electrical properties of the external device plugged into the audio port are measured at a plurality of frequencies. A sensitivity of the external device is determined using the one or more electrical properties of the external device measured using the electrical measurement device. An output to the audio port is adjusted based on the sensitivity.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: January 16, 2018
    Assignee: BLACKBERRY LIMITED
    Inventors: Robert William Lowles, Christian Lorenz
  • Patent number: 9829602
    Abstract: Method and system is described to exploration and development hydrocarbon resources. The method involves operations for exploring and developing hydrocarbons with one or more unmanned vehicles. The unmanned vehicles are used to obtain one or more samples that may be used to identify hydrocarbon systems, such as hydrocarbon seeps.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: November 28, 2017
    Assignee: ExxonMobil Upstream Research Company
    Inventors: William E. Bond, Robert J. Pottorf
  • Patent number: 9816972
    Abstract: The present invention includes a method for distinguishing between a natural source of deep gas and gas leaking from a CO2 storage reservoir at a near surface formation comprising: obtaining one or more surface or near surface geological samples; measuring a CO2, an O2, a CH4, and an N2 level from the surface or near surface geological sample; determining the water vapor content at or above the surface or near surface geological samples; normalizing the gas mixture of the CO2, the O2, the CH4, the N2 and the water vapor content to 100% by volume or 1 atmospheric total pressure; determining: a ratio of CO2 versus N2; and a ratio of CO2 to N2, wherein if the ratio is greater than that produced by a natural source of deep gas CO2 or deep gas methane oxidizing to CO2, the ratio is indicative of gas leaking from a CO2 storage reservoir.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: November 14, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Katherine Romanak, Philip C. Bennett
  • Patent number: 9809725
    Abstract: A paint composition, which comprises a stanchion-encapsulated pigment such as titanium dioxide, can provide enhanced paint quality with reduced cost.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: November 7, 2017
    Assignee: Encapsys, LLC
    Inventors: Nianxi Yan, John Charles Debraal
  • Patent number: 9658234
    Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 23, 2017
    Assignee: AJINOMOTO CO., INC.
    Inventors: Hiroshi Miyano, Akihisa Yahashi, Kazutaka Shimbo, Masakazu Nakazawa, Kazuo Hirayama
  • Patent number: 9645107
    Abstract: Ion-selective electrodes (ISE's) optimized for analyte determinations and provides methods and apparatus for conditioning ion selective electrodes. The conditioning methods and apparatus are particularly useful for ISE's selective for, difficult to condition, less stable and temperature sensitive products, an are based on a concentration gradient and/or a short exposure to an increased temperature.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: May 9, 2017
    Assignee: Pion Inc.
    Inventor: Hugo Bohets
  • Patent number: 9574861
    Abstract: Disclosed is tagged ammunition, methods for making it, using it and detecting it to reduce gun violence. When implemented together with a smart phone coupled readers, standalone readers, or at a security center, software is included to allow integration of signals detected by multiple readers in the vicinity to map detectable ammunition detected by readers designed to detect tagged ammunition as a proxy for loaded firearms. This makes possible securing an area of interest, when combined with placing of at least one networkable reader in the vicinity of the area of interest; and connecting the one or more readers to a monitoring center. Such monitoring centers may be associated with schools, shopping malls, streets, public meetings, public events, housing complexes, an area being swept for loaded guns, an area being monitored for gang activity, or even a residence.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: February 21, 2017
    Inventors: Nihaal Nath, Rattan Nath
  • Patent number: 9556213
    Abstract: Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a “next generation” of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: January 31, 2017
    Inventors: Sergei A. Vinogradov, David F. Wilson
  • Patent number: 9528144
    Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 27, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Patent number: 9506937
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: November 29, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 9506932
    Abstract: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterized in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: November 29, 2016
    Assignee: BIOMERIEUX, INC.
    Inventors: Yannick Charretier, Jean-Philippe Charrier, Christine Franceschi, Gilles Zambardi, Tiphaine Cecchini, Elodie Degout-Charmette
  • Patent number: 9465040
    Abstract: The present invention provides a method for profiling phytohormone levels in plant tissue or tissue of other plastid containing organisms, i.e. a method for the simultaneous determination of a multitude of phytohormone levels in plant tissue or tissue of other plastid containing organisms.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 11, 2016
    Assignee: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Regine Fuchs, Martin Dostler, Maria Wahl, Benjamin Hentschel, Ralf Looser
  • Patent number: 9422793
    Abstract: A technique provides a system and methodology for detecting and monitoring erosion in various environments, including downhole environments. A tracer element is located in a component such that sufficient erosion of the component due to fluid flow exposes the tracer element. A monitoring system is disposed for cooperation with the tracer element such that exposure of the tracer element is detected by the monitoring system. The monitoring system outputs appropriate data indicative of the erosion to enable adjustments to the fluid flow.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: August 23, 2016
    Assignee: Schlumberger Technology Corporation
    Inventors: Luiz Gomes, Stephen D. Mason, Francois M. Auzerais, Robert Krush, Mehmet Parlar
  • Patent number: 9341641
    Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: May 17, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thorsten Brueckner, Timo Klein
  • Patent number: 9291609
    Abstract: An exemplary sensor system for a fuel transport vehicle can comprise a fuel marker sensor positioned between a fuel storage chamber of the vehicle and an access valve for the fuel storage chamber of the vehicle. The fuel marker sensor can be configured to measure one or more characteristics of one or more fuel markers present in the fuel adjacent the sensor, such as when the marked fuel is unloaded at a retail station. The one or more characteristics can comprise concentration and/or identity of the one or more fuel markers in the fuel. Based on the measured characteristics of the one or more fuel markers, the sensor system can identify the fuel and/or can determine whether the fuel has been adulterated after the marked fuel was last measured, such as when the marked fuel was loaded into the vehicle.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: March 22, 2016
    Assignee: UT-Battelle, LLC
    Inventors: Dennis Duncan Earl, Timothy J. McIntyre, David L. West
  • Patent number: 9267371
    Abstract: Methods of tracing fracking liquid in oil or gas bearing formations using plural unique oligonucleotide markers. Method includes pumping the plural volumes of fracking liquid, each marked with a unique oligonucleotide, into the formation, thereby defining plural fracture zones in the formation, and, pumping fluids out of the formation while taking plural fluid samples. Then, analyzing the concentration of the unique oligonucleotides in each of the plural fluid samples, and, calculating the ratio of each of the plural volumes of fracking liquid recovered for each of the plural fluid samples according to the concentration of the unique oligonucleotides present in each of the plural samples. And, then, establishing the quantity of the plural volumes of fracking liquids removed from the plural fracture zones.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: February 23, 2016
    Assignee: Trace Logic, Inc
    Inventors: Tyler W. Blair, J. Lynn Myers
  • Patent number: 9260957
    Abstract: The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well. The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: February 16, 2016
    Assignee: Total SA
    Inventors: Annie Commarieu, Fabrice Aubertin, Nicolas Crowther, Cédric Louis, Pascal Perriat, Matteo Martini, Olivier Tillement
  • Patent number: 9206683
    Abstract: Tracing fracking liquid in oil and gas wells using unique DNA sequences. For each of the DNA sequences, bonding to magnetic core particles, and encapsulating them with silica. Pumping the volumes of fracking liquid, each marked with one of the unique DNA sequences, into the well. Pumping fluids out of the well while taking fluid samples. For each of the plural fluid samples, gathering the silica encapsulated DNA using magnetic attraction with the magnetic core particles, dissolving away the silica shells, thereby separating the plural unique DNA sequences form the magnetic core particles, and analyzing the concentration of the unique DNA sequences in each of the plural fluid samples. Then, calculating the ratio of each of the volumes of fracking liquid recovered for each of the fluid samples, and thereby establishing the quantity of the volumes of fracking liquids removed from the fracture zones.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: December 8, 2015
    Assignee: Trace Logic, Inc.
    Inventors: Tyler W. Blair, Richard K. Baldwin
  • Patent number: 9194226
    Abstract: Tracing fracking liquid in oil and gas wells using unique DNA sequences. For each of the DNA sequences, bonding to magnetic core particles, and encapsulating them with silica. Pumping the volumes of fracking liquid, each marked with one of the unique DNA sequences, into the well. Pumping fluids out of the well while taking fluid samples. For each of the plural fluid samples, gathering the silica encapsulated DNA using magnetic attraction with the magnetic core particles, dissolving away the silica shells, thereby separating the plural unique DNA sequences form the magnetic core particles, and analyzing the concentration of the unique DNA sequences in each of the plural fluid samples. Then, calculating the ratio of each of the volumes of fracking liquid recovered for each of the fluid samples, and thereby establishing the quantity of the volumes of fracking liquids removed from the fracture zones.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: November 24, 2015
    Inventor: Tyler W. Blair
  • Patent number: 9188592
    Abstract: Disclosed herein are methods and kits useful in the detection of protein folding and in the identification of compounds that promote proper protein folding. In one example approach, fluorophores and a protein tag are incorporated into a nascent polypeptide within a ribosome-nascent-chain complex during cell free translation and the resulting labeled ribosome-nascent-chain complex is conjugated to a solid surface via the tag. Fluorescence imaging via FRET is then preformed to assess the folding state of the ribosome-nascent-chain complex under a variety of conditions.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: November 17, 2015
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: William Skach, LeeAnn Rooney, Hideki Shishido, Zhongying Yang
  • Patent number: 9127181
    Abstract: A main object of the invention is to provide a taggant particle group that has a plurality of authentication steps and an excellent anti-counterfeit effect and can be applied to various anti-counterfeit media.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: September 8, 2015
    Assignee: DAI NIPPON PRINTING CO., LTD.
    Inventors: Tsuyoshi Yamauchi, Mitsuru Kitamura, Manabu Yamamoto, Akiko Kitamura, Yoko Sekine
  • Patent number: 9079150
    Abstract: An identification and verification system and a process for said identification and verification of documents is disclosed, which is based on the use of nanoparticles embedded or adsorbed in the document support, utilizing the different optical reflectance characteristics thereof in order to obtain, by combining several nanoparticles with specific characteristics, a high effectiveness in the identification of counterfeits.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 14, 2015
    Assignee: UNIVERSIDAD DE ZARAGOZA
    Inventors: Manuel Arruebo Gordo, Clara Yagüe Gómez, Jesús Santamaría Ramiro
  • Patent number: 9080987
    Abstract: A process for detecting oil or lubricant contamination in the production of an article by adding a Stokes-shifting taggant to an oil or lubricant of a machine utilized to produce the article or a component thereof, irradiating the articles produced with a first wavelength of radiation, and monitoring the articles for emission of radiation at a second wavelength. The taggant can be in the form of a composition containing a Stokes-shifting taggant, which absorbs radiation at a first wavelength and emits radiation at a second wavelength, different from said first wavelength, dissolved or dispersed in an oil or lubricant.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: July 14, 2015
    Assignee: ALTRIA CLIENT SERVICES, INC.
    Inventor: William James Faenza
  • Patent number: 9046453
    Abstract: A system for tracking one or more subjects for collecting airborne contaminants. The system includes one or more subjects configured to collect air contaminants. Each of the one or more subjects includes an identification tag encoded with identification information identifying the each subject. The system further includes an identification reader configured to decode the identification information encoded within the identification tag of a scanned one of the one or more identification tags. A computer receives and stores the decoded identification information in a record in a database. The computer may also receive and stored an identification code for a user who scanned the scanned identification tag in the record in the database. Additional records in the database are created each time the identification tag of one of the one or more subjects is scanned. The one or more subjects are thereby tracked as they collect airborne contaminants and are incubated.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: June 2, 2015
    Assignee: Veltek Associates, Inc.
    Inventors: Rosario S. Calio, Mark A. Phillips, John Joyce
  • Publication number: 20150141264
    Abstract: The invention provides a method for in-field detection of a distinctive marker. The method includes providing a sample from an article of interest and analyzing the sample to detect the presence of the distinctive marker. The analysis is performed using an in-field detection instrument. The in-field detection instrument includes a microsystem configured to perform sample in-answer out analysis and detect the presence of the distinctive marker in the sample.
    Type: Application
    Filed: August 28, 2014
    Publication date: May 21, 2015
    Inventors: Lawrence Jung, MingHwa Benjamin Liang
  • Patent number: 9029158
    Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: May 12, 2015
    Assignee: California Institute of Technology
    Inventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan
  • Patent number: 8999653
    Abstract: The instant invention provides for methods for detecting the internalization of a transmembrane protein of interest expressed at the surface of a cell. More specifically, the methods involve (a) labelling the protein of interest with a fluorescent metal complex, the lifetime of which is greater than 0.1 ms, (b) adding to the reaction medium a composition capable of causing the internalization of the protein of interest, (c) adding to the reaction medium (1) a modulating agent which is a fluorescent FRET acceptor compound compatible with the fluorescent metal complex, the final concentration of which in the reaction medium is greater than 10?7M; or (2) a reducing agent, the redox potential of which is less than +0.1 V and preferably between 0.25 and 0.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: April 7, 2015
    Assignee: Cis-Bio International
    Inventors: Jurriaan Zwier, Robert Poole, Herve Ansanay, Michel Fink, Eric Trinquet
  • Patent number: 8999725
    Abstract: In one embodiment of the present application, a stimulus-responsive gel is disclosed with optical characteristic molecule introduced therein that is capable of easily and securely converting a volume change responding to external stimulus to optical data being easy to handle in the construction of sensor system; an external stimulus measuring apparatus making use of the same; and a method of measuring external stimulus therewith.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: April 7, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Takashi Miyata, Tadashi Uragami, Kaori Okawa
  • Patent number: 8999652
    Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: April 7, 2015
    Assignee: Primity Bio, Inc.
    Inventors: Peter Oliver Krutzik, Thomas Scott Wehrman
  • Publication number: 20150093835
    Abstract: The present invention relates to a particle comprising a core which comprises an oxide selected from rare earth oxides alone or in a mixture with metal oxides and which is coated with a layer of silica functionalized with a coupling agent comprising at least one chemical function soluble in a hydrophobic solvent, and to a composition comprising at least one such particle. The present invention likewise relates to the method for preparing same and to various uses thereof.
    Type: Application
    Filed: November 25, 2014
    Publication date: April 2, 2015
    Inventors: Olivier Raccurt, Jorice Samuel
  • Patent number: 8969100
    Abstract: Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby identifying the location of the sentinel lymph node by means of fluorescence. Subsequently, the sentinel lymph node is extracted. With respect to the sentinel lymph node extracted with quantum dots injected, structural analysis is conducted by means of precision fluorescence measurement which uses a confocal fluorescence microscope for monomolecular observation. Specifically, the fluorescence intensity is measured with respect to each of multiple areas in the sentinel lymph nodes, and out of the multiple areas measured, one or more areas are detected as afferent lymph vessel inflow regions in descending order of fluorescence intensity.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: March 3, 2015
    Assignees: Tohoku University, Konica Minolta Medical & Graphic, Inc.
    Inventors: Makoto Hikage, Kohsuke Gonda, Motohiro Takeda, Takashi Kamei, Noriaki Ohuchi, Hideki Gouda, Yasushi Nakano
  • Patent number: 8969622
    Abstract: In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: March 3, 2015
    Assignee: Vanderbilt University
    Inventors: Eva M. Harth, James E. Crowe, Jr., Kui Huang, Sharon K. Hamilton, Heidi E. Hamm, Bryan Voss
  • Patent number: 8961624
    Abstract: A method for marking a petroleum hydrocarbon or liquid biologically derived fuel by adding to the petroleum hydrocarbon or biologically derived fuel at least one compound having formula (I), wherein G1 represents an organic functional group having from four to forty carbon atoms.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: February 24, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: George David Green, Raymond John Swedo
  • Patent number: 8962337
    Abstract: A marker system for applying to surfaces of items, articles, goods, vehicles and/or premises, said marker system comprising: a marker comprising a temperature resilient medium having a predefined carbonization temperature capable of securing the marker system onto a surface; wherein the medium contains an inorganic matrix having a predefined fusing point lower than the predefined carbonization temperature of the medium; such that when the marker system is subjected to temperatures above the predefined carbonization temperature of the medium, the inorganic matrix fuses to the marker to form an adhesive protective layer thereby securing the marker onto said surface. A composition comprising the marker system. An item, an article, a good, a vehicle and/or premises comprising a surface impregnated with the marker system.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 24, 2015
    Assignee: Smartwater Research Limited
    Inventor: Michael Cleary
  • Publication number: 20150024423
    Abstract: Embodiments include types of programmable surface-enhanced spectroscopy (SES) particles (PSPs), including PSP 200 having a SES-active surface 202 and a programmable reporter 206 associated with the SES surface 202 and methods of fabricating and using same. The programmable reporter 206 provides that the PSP 200 will return a controlled but variable signal in response to spectroscopic interrogation. The spectroscopic signal can be triggered to change externally or the signal may naturally vary over time.
    Type: Application
    Filed: July 31, 2014
    Publication date: January 22, 2015
    Inventor: Michael J. Natan
  • Publication number: 20140341983
    Abstract: Solid Oral Dosage Forms (SODFs) comprising Self Monitoring and Reporting Therapeutics (SMART™) adherence technology are provided which require no or minimal modification of clinical trial materials (CTMs) or marketed drug while providing tamper resistant (literally foolproof) measurement of adherence that is highly accurate and without altering the chemical, manufacturing, and controls (CMC) of the CTM or marketed drug.
    Type: Application
    Filed: September 14, 2012
    Publication date: November 20, 2014
    Inventors: Donn M. Dennis, Richard J. Melker
  • Patent number: 8871517
    Abstract: A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: October 28, 2014
    Assignee: Bayer Healthcare LLC
    Inventors: Jing Lin, Fu Hsiung Tsai, Huan-Ping Wu, Nicole D. Ellis, Henry C. Arndt
  • Patent number: 8865420
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: October 21, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • Patent number: 8852947
    Abstract: A photographic material for image display including an intimately sorbed contrast agent that provides a contrast layer against which the recorded image can be seen regardless of the nature and color of the background.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: October 7, 2014
    Assignee: Smartwater Research Limited
    Inventors: Michael Cleary, Marcello Vitale, Sharon Robinson
  • Publication number: 20140273246
    Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Patent number: 8828729
    Abstract: One embodiment is a SERS enhancing substrate which includes a porous substrate and a Raman enhancing material associated with a surface of the porous substrate. The Raman enhancing material may be a Raman enhancing metal or other Raman enhancing material. The Raman enhancing material may also be configured to improve binding of a taggant to the substrate. The substrate described above may be included in a sample vessel useful for the flow-through analysis of large sample volumes, or for the rapid analysis of very dilute samples. Other embodiments include methods and systems for detecting taggants with SERS and similar techniques.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: September 9, 2014
    Assignee: Cabot Corporation
    Inventors: Michael J. Natan, Marcelo Eduardo Piotti
  • Patent number: 8802450
    Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: August 12, 2014
    Assignee: Sirigen, Inc.
    Inventors: Brent S. Gaylord, Janice W. Hong, Tsu-Ju Fu, Cheng-Jun Sun, Russell Baldocchi
  • Patent number: 8796040
    Abstract: A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 5, 2014
    Assignees: The Furukawa Electric Co., Ltd., The University of Tokushima
    Inventors: Hideki Aizawa, Michio Ohkubo, Michihiro Nakamura, Hirokazu Miyoshi
  • Patent number: 8796030
    Abstract: The present invention relates generally to encoding samples. More specifically, it relates to barcodes and compositions involving upconverters and methods including them. In a composition aspect of the invention, a composition comprising two or more lanthanide materials is provided. Each lanthanide material comprises a host, an absorber, and an emitter, and the materials emit detectable electromagnetic radiation upon excitation with absorbable electromagnetic energy. One or more relative ratios of emission intensities uniquely identify the composition.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: August 5, 2014
    Assignee: Parallel Synthesis Technologies, Inc.
    Inventor: Robert C. Haushalter
  • Publication number: 20140205749
    Abstract: A detectable taggant is described. The detectable taggant may include at least one nano-antenna having a resonant frequency of about 300 GHz to about 800 THz. The nano-antenna is adapted to be physically or chemically associated with an article of manufacture.
    Type: Application
    Filed: August 14, 2012
    Publication date: July 24, 2014
    Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventor: Christopher J. Rothfuss
  • Patent number: 8778694
    Abstract: Provided herein are batch methods and devices for enriching trace quantities of impurities in gaseous mixtures, such as hydrogen fuel. The methods and devices rely on concentrating impurities using hydrogen transport membranes wherein the time period for concentrating the sample is calculated on the basis of optimized membrane characteristics, comprising its thickness and permeance, with optimization of temperature, and wherein the enrichment of trace impurities is proportional to the pressure ratio Phi/Plo and the volume ratio V1/V2, with following detection of the impurities using commonly-available detection methods.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: July 15, 2014
    Assignee: Uchicago Argonne, LLC
    Inventors: Shabbir Ahmed, Sheldon H. D. Lee, Romesh Kumar, Dionissios D. Papadias
  • Patent number: 8778624
    Abstract: Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like, exhibit decreased non-specific binding to solid phases and provide increased assay sensitivity.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: July 15, 2014
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Sharpe, Qingping Jiang