Hemoglobin, Myoglobin, Or Occult Blood Patents (Class 436/66)
  • Patent number: 10989714
    Abstract: Provided is a method for measuring a glycoprotein using an enzymatic method, and the method includes simplified steps.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: April 27, 2021
    Assignee: ARKRAY, Inc.
    Inventor: Satoshi Yonehara
  • Patent number: 10883927
    Abstract: A hemoglobin detecting device includes a shell component connected with a fixing part that engages with an outer side of a smart device. A processor unit, a light source, a light detection module and a transmission unit are mounted inside the shell component. The light source generates a first light beam, and the light detection module receives a second light beam that is generated when the first light beam travels through an analyte solution and is reflected. The processor unit determines whether the absorption spectrum of the analyte solution matches a target spectrum, and generates a result information according to the detection. The transmission unit transmits the result information to the smart device and displays an indication of the result. The hemoglobin detecting device provides a fast and accurate way to detect blood in a stool solution, and can be applied to and cooperate with all kinds of smart devices.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: January 5, 2021
    Assignee: Taiwan Redeye Biomedical Inc.
    Inventors: Shuo-Ting Yan, I-Hua Wang
  • Patent number: 10876939
    Abstract: An apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 29, 2020
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Sari Tikanoja, Annu Suoniemi, Johan Finell, Lili Arabshahi
  • Patent number: 10823665
    Abstract: The invention provides a smart toilet seat having an occult blood detecting module, the occult blood detecting module further including: a case, a power unit, a light source, a photo sensor, and a first processor; wherein the occult blood detecting module being able to be lowered to slightly above water seal inside a toilet; the light source emitting the emitted light onto an excrement solution below surface of the water seal, the photo sensor receiving a reflected light reflected by the excrement solution and the toilet to generate a detection signal; the first processor receiving and processing the detection signal from the photo sensor to generate a detection result. Alternatively, the case includes an extension section disposed with a reflector and a filter, which can be lowered below the water seal for detection.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: November 3, 2020
    Assignee: TAIWAN REDEYE BIOMEDICAL INC.
    Inventors: Shuo-Ting Yan, Kuan-Wei Su, Chen-Chung Chang, I-Hua Wang
  • Patent number: 10761101
    Abstract: A test apparatus and method for measuring a concentration of a target by correcting for an impact of hemoglobin are provided. The target measurement method includes measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample, determining variation of the absorbance of the target according to the measured absorbance of the hemoglobin, and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: September 1, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sung Hwa Lee, Takayuki Taguchi, Hye Kyung Park
  • Patent number: 10627395
    Abstract: The present disclosure provides methods and systems for detecting a presence or absence of one or more analytes in small volumes of samples. The detected presence or absence of the one or more analytes can be used for a variety of applications including biomonitoring.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: April 21, 2020
    Assignee: NEWOMICS INC.
    Inventors: Daojing Wang, Pan Mao
  • Patent number: 10317381
    Abstract: An apparatus and method for measuring hydrogen peroxide concentration in water to an accuracy of 0.1 ppm comprises a colorimetric assay method to determine hydrogen peroxide concentration. The assay is monitored spectophotometrically at a desired wavelength. Each sample is corrected relative to a control sample and hydrogen peroxide concentration determined with respect to a standard curve.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: June 11, 2019
    Inventors: Jim Shubat, Gerben Op Den Buijs, Ludo Feyen
  • Patent number: 10191054
    Abstract: A device for full blood count includes first channel and second channels separated from each other. The device further includes a first inlet configured to provide a whole blood sample to the first and second channels, a second inlet configured to provide a lysis agent for white blood cell count in to the first channel, a third inlet configured to provide a quench solution to the first channel, and a fourth inlet configured to provide a lysis agent for hemoglobin measurement to the second channel.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: January 29, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: David M. Pettigrew, James D. Gwyer
  • Patent number: 9938557
    Abstract: Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation. Computer-readable storage devices and systems, e.g., for use in the described methods.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: April 10, 2018
    Assignee: The General Hospital Corporation
    Inventor: John M. Higgins
  • Patent number: 9826736
    Abstract: A disinfectant wipe and disinfectant composition which exhibits exceptional antimicrobial activities as a result of the synergistic combination of a quaternary ammonium salts and 1,2-alkandiol is provided. The wipe is pre-impregnated with a disinfectant composition which comprises a quaternary ammonium salt, a 1,2-alkanediol with 5-10 carbon atoms, a glycol ether, a surfactant, a pH regulating agent, and water, and optionally alcohol. A method of preparation and a process for disinfecting a surface with the wipe composition are also provided.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: November 28, 2017
    Assignee: Professional Disposables International, Inc.
    Inventors: Lisa A. Napolitano, Phyllis Vitolo, Michael V. Monticello, Travis Duong, Roy Blank
  • Patent number: 9482621
    Abstract: A method of rapidly detecting trace materials including biohazards, toxins, radioactive materials, and narcotics in situ is disclosed. A corresponding apparatus is disclosed. A trace of the material is collected on a pad of the card component, collected by swiping the pad on suspected surface or exposure to the suspected air volume. A novel card component is disclosed that when inserted in a chemical detection unit (CDU), releases reaction chemicals from flexible walled capsules in desired sequence. The exposed pad containing trace material and chemicals are heated in the chemical detection unit to produce a spectral pattern that is analyzed by the optical electronics in the CDU and results are displayed, stored and/or transmitted over a communications network.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: November 1, 2016
    Assignee: DETECTACHEM, LLC
    Inventors: Vaughan L. Clift, Kristin L. Harriman, Richard L. Pettys, David M. Headley, Tiffany M. Conerly
  • Patent number: 9192709
    Abstract: A rigid tubular piece and a cassette assembly for extracorporeal blood circulation having the rigid tubular piece are disclosed. The rigid tubular piece is used for submitting fluid circulating therein to measurements and includes a protrusion or a recess in correspondence of at least an end connector. A blood treatment medical apparatus using the cassette assembly is also disclosed. The apparatus is able to detect if the right rigid tubular piece is in proper position before authorizing measurements of a blood property.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: November 24, 2015
    Assignee: Gambro Lundia AB
    Inventors: Francesco Fontanazzi, Luca Caleffi, Marco Paraluppi, Giacomo Grandi
  • Patent number: 9157837
    Abstract: A collection device for use in connection with off-device testing of collected samples. The device includes a first panel having one or more apertures for receiving samples, a second panel opposite the first panel, and a removable tab having a first portion and a second portion. The first portion is aligned with at least one of apertures on the first panel and constructed such that depositing the sample through the at least one aperture causes the sample to be directly deposited on the first portion of the tab, and the second portion includes a sample-free grasping area accessible from an exterior of the device for removing the tab. A method of obtaining a sample is also disclosed.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: October 13, 2015
    Assignee: Immunostics, Inc.
    Inventor: Vincent Lastella
  • Patent number: 9063047
    Abstract: A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: June 23, 2015
    Assignees: UT-Battelle, LLC, DH Technologies Development PTE. LTD.
    Inventors: Gary Van Berkel, Thomas Covey
  • Publication number: 20150147777
    Abstract: An integrated fluidic device comprising includes an input chamber that provides an input of a sample fluid, and a first overspill chamber in fluid communication with the input chamber. A metering conduit is in fluid communication with the fluid input chamber and the first overspill chamber. The metering conduit meters a first metered volume of fluid from the sample fluid, and the first overspill chamber receives fluid in excess of the first metered volume of fluid. A second overspill chamber is in fluid communication with the metering conduit. The metering conduit meters a second metered volume of fluid from the first metered volume of fluid, and the second overspill chamber receives fluid from the first metered volume of fluid in excess of the second metered volume of fluid. The second overspill chamber has a fluid actuated closable valve for controlling the metering of the second metered volume of fluid.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 28, 2015
    Applicant: SHARP KABUSHIKI KAISHA
    Inventor: Pamela Ann Dothie
  • Publication number: 20150140670
    Abstract: Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator solution including a tetramethylbenzidine (TMB) solution, the indicator being configured to change color; a collection device configured to collect a test sample from a subject. The kit may also include a hemoglobin physiologic level identifier legend, the legend indicating 1) at least one color of the indicator and 2) a physiologic level and/or range of the hemoglobin and/or disease state associated with the color.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Inventors: WIlbur A. Lam, Morgan Byrd, Erika Tyburski, Michael L. McKinnon, Siobhan O'Connor, Nathan A. Hotaling
  • Patent number: 9034264
    Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 19, 2015
    Assignee: Highland Biosciences Limited
    Inventor: Richard Day
  • Patent number: 9029161
    Abstract: A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: May 12, 2015
    Assignee: Academisch Medisch Centrum
    Inventors: Maurice Aalders, Rolf Bremmer
  • Publication number: 20150125900
    Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Applicant: SYSMEX CORPORATION
    Inventors: Takaaki NAGAI, Noriyuki NARISADA, Daigo FUKUMA
  • Publication number: 20150111234
    Abstract: A portable, hand-held glucose testing device includes a housing configured to accommodate a plurality of test sensors in a stacked arrangement and having a wall with an opening defined therein. A plurality of packaged test sensors is stacked in alignment with one another within the housing. Each of the test sensors is packaged within a blister package. The blister package includes a blister package housing and a cover foil overlying a surface of the blister package housing and the test sensor. A drive slide is configured to displace one of the plurality of packaged test sensors out of alignment with other packaged test sensors. A knife mechanism is configured to pierce through the cover foil, and to engage and urge the test sensor to extend through the opening for receiving a sample. A meter contact is configured to engage the test sensor when the test sensor extends through the opening.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Inventors: Steven C. Charlton, Allen Brenneman
  • Publication number: 20150093771
    Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.
    Type: Application
    Filed: December 2, 2014
    Publication date: April 2, 2015
    Inventors: Patrick Griss, Rainer Jaeggi, Goran Savatic, Vuk Siljegovic
  • Patent number: 8974732
    Abstract: A method for determining the area of an analysis chamber covered by a biologic fluid sample quiescently residing within the chamber is provided. The chamber has a first panel with an interior surface, and a second panel with an interior surface, both of which panels are transparent.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: March 10, 2015
    Assignee: Abbott Point of Care, Inc.
    Inventors: Niten V. Lalpuria, Stephen C. Wardlaw
  • Patent number: 8945930
    Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: February 3, 2015
    Assignee: Bayer HealthCare LLC
    Inventor: Kevin Chang
  • Publication number: 20150024503
    Abstract: An object of the present invention is to provide a method for analyzing hemoglobins which can accurately separate hemoglobins in a short time by liquid chromatography. The present invention provides a method for analyzing hemoglobins by liquid chromatography which includes pre-treating a sample with an oxidant and a binder for trivalent heme iron.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 22, 2015
    Inventors: Hiroaki TAIRA, Takayuki OKA
  • Patent number: 8932864
    Abstract: Provided is a method and device for identifying glycated protein in a sample using a matrix including a boronic acid moiety that binds glycated proteins.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: January 13, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sang-kyu Kim, Sung-ha Park, Kyung-mi Song, Soo-suk Lee, Youn-suk Choi
  • Patent number: 8906605
    Abstract: An analytical method of post-translational modifications in hemoglobin is disclosed. The analytical method comprises the steps of providing a blood comprising the hemoglobin with post-translational modification of nitration, nitrosylation, or oxidation; performing an extraction process to the blood by an organic solvent; quantifying the hemoglobin by a fluorescent spectrometry; hydrolyzing the hemoglobin into a plurality of peptides by an enzyme; and using a nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry to characterize and quantify the post-translational modifications of the hemoglobin.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: December 9, 2014
    Assignee: National Chung Cheng University
    Inventors: Hauh-Jyun Candy Chen, Yu-Chin Chen
  • Publication number: 20140329262
    Abstract: This invention relates to a testing system for assessing the level of a biochemical marker, comprising a disposable device (2) with a sample inlet (4) and a at least one visible detection compartment (5A, 5B), arranged with composition including a chemical means (Y) for direct detection of said biochemical marker, wherein said composition also includes an inhibitor (Z) arranged to first detection compartment (5A) being arranged to block the biochemical marker up to a certain concentration.
    Type: Application
    Filed: November 22, 2012
    Publication date: November 6, 2014
    Inventors: Mathias Karlsson, Sofia Hiort Af Ornäs
  • Patent number: 8845968
    Abstract: The present application provides apparatus (300, 400) and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator (108, 109, 110). Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: September 30, 2014
    Assignee: Highland Biosciences Limited
    Inventor: Richard Day
  • Publication number: 20140256051
    Abstract: Methods and apparatuses of the present disclosure provide accurate and precise radiation dosimetry based on decarboxylation of a reactant upon exposure to ionizing radiation. The decarboxylation reaction yields carbon dioxide and stable end products, which can be detected and measured, and correlated to determine an amount of radiation exposure. The reactants include carboxyl acids, such as amino acids and others occurring naturally in mammals. The dosimetry may be performed in real-time or retrospectively by assaying a sample of tissue from a patient. Also disclosed is a device which detects and measures radiation dosages based on decarboxylation of a reactant contained therein.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 11, 2014
    Applicant: University of Rochester
    Inventors: William A. Bernhard, Richard M. Watson, Paul Black
  • Patent number: 8828322
    Abstract: Devices and methods for measuring prothrombin time (PT) and hematocrit (HCT) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring HCT and PT of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (AC) provided by the sensor device is used to measure and calculate HCT and PT of blood test using the reactance analysis.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: September 9, 2014
    Assignee: Apex Biotechnology Corp.
    Inventors: Sz-Hau Chen, Yueh-Hui Lin, Ching-Yuan Chu, Chu-Ming Cheng, Guan-Ting Chen, Yi-Chen Lu, Thomas Y.S. Shen
  • Patent number: 8828730
    Abstract: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: September 9, 2014
    Assignee: Synapse B.V.
    Inventors: Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
  • Patent number: 8802442
    Abstract: The apparatus and method for detecting blood in urine or feces includes a photodetector configured to detect a transient light emitted in a toilet bowl by luminol and an oxidizer catalyzed by iron in the blood. The apparatus may include dispensers for the luminol, the oxidizer and a base. The apparatus may include a microprocessor and a network connection and may perform statistical analyzes, store data and alert the patient or a healthcare provider if blood is detected. The photodetector may be configured to detect light emitted in the toilet bowl by a fluorophore present in the water and excited by the transient light from the luminol and oxidizer.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: August 12, 2014
    Inventors: Eric B. Wheeldon, Robert J. Barsotti
  • Patent number: 8790577
    Abstract: A sample analyzer is disclosed. In one embodiment, the sample analyzer includes an analysis section for analyzing a sample by using a reagent to obtain numerical data and distribution diagram of particles contained in the sample; a display device; an information receiver for receiving an input of reagent information assigned to the reagent; a determination section configured for determining whether or not the reagent satisfies a condition to determine that the reagent is a genuine product based on the reagent information; and a controller that controls the display device to display both the numerical data and the distribution diagram if the reagent satisfies the condition by the determination section and to display the numerical data without displaying the distribution diagram if the reagent does not satisfy the condition by the determination section.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: July 29, 2014
    Assignee: Sysmex Corporation
    Inventors: Toru Mizumoto, Ryuichiro Ebi, Keisuke Tsutsumida, Yousuke Tanaka, Junya Inoue
  • Patent number: 8778687
    Abstract: A method and apparatus for determining the hematocrit of a blood sample disposed within an analysis chamber, the method including the steps of: a) imaging at least a portion of the sample that contains one or more red blood cells and one or more areas void of red blood cells; b) determining a representative optical density value for a plurality of image units optically aligned with portions of the red blood cells, and assigning an optical density first boundary value to those image units; c) determining a representative optical density value of a plurality of image units optically aligned with the one or more regions of the sample devoid of red blood cells, and assigning a second optical density boundary value to those image units; and d) determining the hematocrit of the sample.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: July 15, 2014
    Assignee: Abbott Point of Care, Inc.
    Inventors: Robert A. Levine, Stephen C. Wardlaw, Darryn Unfricht, Niten V. Lalpuria
  • Publication number: 20140193921
    Abstract: A test apparatus and method for measuring a concentration of a target by correcting for an impact of hemoglobin are provided. The target measurement method includes measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample, determining variation of the absorbance of the target according to the measured absorbance of the hemoglobin, and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target.
    Type: Application
    Filed: December 31, 2013
    Publication date: July 10, 2014
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sung Hwa LEE, Takayuki TAGUCHI, Hye Kyung PARK
  • Publication number: 20140162369
    Abstract: The present invention aims to provide a method of measuring hemoglobins which can measure hemoglobins in a short time at high accuracy. The present invention also aims to provide a method of measuring hemoglobin A1c, a method of simultaneously measuring hemoglobin A1c and hemoglobin F, a method of simultaneously measuring hemoglobin A1c and hemoglobin A2, and a method of simultaneously measuring hemoglobin A1c and abnormal hemoglobins, each utilizing the above-mentioned method of measuring hemoglobins by liquid chromatography. The present invention relates to a method of measuring hemoglobins by liquid chromatography. A column used in the method is filled with, as a column-packing material, cation-exchangeable particles including cross-linked polymer particles having a cation-exchange-group-containing polymer bonded to the surface of the cross-linked polymer particles, and the column shows a pressure value of 9.8×103 Pa or higher and 29.4×105 Pa or lower when an eluent for measurement is delivered at 1.
    Type: Application
    Filed: January 11, 2012
    Publication date: June 12, 2014
    Applicant: SEKISUI MEDICAL CO., LTD
    Inventor: Kazuyuki Oishi
  • Patent number: 8748186
    Abstract: A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: June 10, 2014
    Assignee: Abbott Laboratories
    Inventors: Richard Kendall, John W. Roche
  • Publication number: 20140127670
    Abstract: A disposable blood analysis cartridge may include a sample collection reservoir, an absorbance measurement channel, and an optical light scattering measurement channel. One or more valves may be disposed between the sample collection reservoir and the absorbance measurement channel and/or the optical light scattering measurement channel. A negative pressure may be applied to the cartridge to pull sample from the sample collection reservoir through the one or more valves and into the absorbance measurement channel and/or the optical light scattering measurement channel. Once the sample is pulled into the absorbance measurement channel and/or the optical light scattering measurement channel, the one or more valves may be closed. With the one or more valves closed, and in some cases, a pusher fluid may be provided to push the fluid sample to other regions of the disposable fluid blood analysis cartridge.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 8, 2014
    Applicant: Honeywell International Inc.
    Inventors: Mark Kelley, Ron Bardell, Robert Janisch, Pamela Wong, Eric Peltola
  • Patent number: 8702941
    Abstract: A method for analyzing hemoglobin by electrophoresis, capable of analyzing hemoglobin A1c (HbA1c) and modified hemoglobin with improved accuracy in a shortened analysis time is provided. The method for analyzing hemoglobin by electrophoresis includes performing electrophoresis under conditions in which an acidic substance having two or more carboxyl groups is present in an electrophoresis solution. At least two of the carboxyl groups of the acidic substance each have an acid dissociation constant (pKa) lower than the pH of the electrophoresis solution at the time of analysis.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: April 22, 2014
    Assignee: ARKARY, Inc.
    Inventors: Yusuke Nakayama, Satoshi Yonehara
  • Patent number: 8703494
    Abstract: Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: April 22, 2014
    Assignee: Relia Diagnostic Systems, LLC
    Inventors: William J. Rutter, Jang H. Han, Taewoo Kwon
  • Patent number: 8679848
    Abstract: A collection device for use in connection with off-device testing of collected samples. The device includes a first panel having one or more apertures for receiving samples, a second panel opposite the first panel, and a removable tab having a first portion and a second portion. The first portion is aligned with at least one of apertures on the first panel and constructed such that depositing the sample through the at least one aperture causes the sample to be directly deposited on the first portion of the tab, and the second portion includes a sample-free grasping area accessible from an exterior of the device for removing the tab. A method of obtaining a sample is also disclosed.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: March 25, 2014
    Assignee: Immunostics, Inc.
    Inventor: Vincent P. LaStella
  • Patent number: 8679847
    Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: March 25, 2014
    Assignee: Bayer Healthcare LLC
    Inventor: Kevin Chang
  • Patent number: 8679420
    Abstract: A device for testing a specimen comprising a first panel, a metering aperture structure having a plurality of metering apertures formed therein for receiving the specimen therethrough, a second panel opposite the first panel, a sheet disposed between the first and second panels, the sheet including a test area aligned with the plurality of metering apertures, a spacer element disposed between the first panel and the sheet, wherein the metering aperture structure is spaced away from the test area thereby improving readability of the testing. A method of manufacturing a specimen testing device is also disclosed.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: March 25, 2014
    Assignee: Immunostics, Inc.
    Inventors: Vincent P. LaStella, Kenneth Kupits
  • Publication number: 20140072996
    Abstract: The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored blood sample or to identify a hemolyzed plasma sample. The present invention also relates to kits for use in the above described methods.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 13, 2014
    Applicant: ABBOTT LABORATORIES
    Inventors: Maciej Adamczyk, Roy Jeffrey Brashear, Phillip G. Mattingly
  • Patent number: 8663559
    Abstract: A sample analyzer that includes a sample preparing section operative to aspirate a sample from a sample container and a measuring section operative to prepare a plurality of measurement samples from the aspirated sample. A control unit is configured to sequentially measure the plurality of prepared measurement samples, obtain a plurality of measurement data for the respective measurement samples, and obtain an analysis result of a predetermined item of the sample based on the plurality of measurement data.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: March 4, 2014
    Assignee: Sysmex Corporation
    Inventors: Masaharu Shibata, Noriyoshi Yoshida
  • Patent number: 8637319
    Abstract: A method for detecting human or animal blood traces on a surface is described. The method is fundamentally based on the reaction of luminol and includes the preliminary operation of atomizing an inorganic powder suspension, such as titania, silica, alumina, hydroxyapatite, or the like, onto the surface to be investigated, after which a composition of luminol, a peroxidic oxidizing agent and an alkaline agent in an amount providing a pH within the range of 10 to 14, is atomized on the surface. A kit for carrying out the detection method of the invention is also described.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: January 28, 2014
    Assignee: Universita' Degli Studi di Torino
    Inventors: Gianmario Martra, Simone Priante, Marco Vincenti
  • Patent number: 8623659
    Abstract: The present invention provides a method for determining sickle-cell zygosity in a subject. The method involves forming a first solution which includes a sample from the subject, a phosphate buffer, a detergent, and a reducing agent and subjecting the first solution to centrifugation to form a second solution and a supernatant; and taking a color reading of the supernatant and of the second solution; optionally filtering the second solution to form a filtrate and a precipitate, and optionally measuring the amount of the precipitation and the absorbance of the filtrate or taking a color reading of the filtrate.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: January 7, 2014
    Assignee: Saint Louis University
    Inventor: Tim R. Randolph
  • Publication number: 20140004612
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Applicant: SYSMEX CORPORATION
    Inventors: Norimasa YAMAMOTO, Takashi YAMATO, Naohiko MATSUO, Satoshi IGUCHI
  • Patent number: 8603828
    Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: December 10, 2013
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Roger Walker, Benedicte Jardin
  • Patent number: RE45074
    Abstract: The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: August 12, 2014
    Assignee: ARKRAY, Inc.
    Inventors: Satoshi Yonehara, Tsuguki Komori