Hemoglobin, Myoglobin, Or Occult Blood Patents (Class 436/66)
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Publication number: 20140256051Abstract: Methods and apparatuses of the present disclosure provide accurate and precise radiation dosimetry based on decarboxylation of a reactant upon exposure to ionizing radiation. The decarboxylation reaction yields carbon dioxide and stable end products, which can be detected and measured, and correlated to determine an amount of radiation exposure. The reactants include carboxyl acids, such as amino acids and others occurring naturally in mammals. The dosimetry may be performed in real-time or retrospectively by assaying a sample of tissue from a patient. Also disclosed is a device which detects and measures radiation dosages based on decarboxylation of a reactant contained therein.Type: ApplicationFiled: March 6, 2014Publication date: September 11, 2014Applicant: University of RochesterInventors: William A. Bernhard, Richard M. Watson, Paul Black
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Patent number: 8828730Abstract: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.Type: GrantFiled: August 5, 2009Date of Patent: September 9, 2014Assignee: Synapse B.V.Inventors: Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
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Patent number: 8828322Abstract: Devices and methods for measuring prothrombin time (PT) and hematocrit (HCT) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring HCT and PT of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (AC) provided by the sensor device is used to measure and calculate HCT and PT of blood test using the reactance analysis.Type: GrantFiled: June 9, 2011Date of Patent: September 9, 2014Assignee: Apex Biotechnology Corp.Inventors: Sz-Hau Chen, Yueh-Hui Lin, Ching-Yuan Chu, Chu-Ming Cheng, Guan-Ting Chen, Yi-Chen Lu, Thomas Y.S. Shen
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Patent number: 8802442Abstract: The apparatus and method for detecting blood in urine or feces includes a photodetector configured to detect a transient light emitted in a toilet bowl by luminol and an oxidizer catalyzed by iron in the blood. The apparatus may include dispensers for the luminol, the oxidizer and a base. The apparatus may include a microprocessor and a network connection and may perform statistical analyzes, store data and alert the patient or a healthcare provider if blood is detected. The photodetector may be configured to detect light emitted in the toilet bowl by a fluorophore present in the water and excited by the transient light from the luminol and oxidizer.Type: GrantFiled: November 29, 2012Date of Patent: August 12, 2014Inventors: Eric B. Wheeldon, Robert J. Barsotti
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Patent number: 8790577Abstract: A sample analyzer is disclosed. In one embodiment, the sample analyzer includes an analysis section for analyzing a sample by using a reagent to obtain numerical data and distribution diagram of particles contained in the sample; a display device; an information receiver for receiving an input of reagent information assigned to the reagent; a determination section configured for determining whether or not the reagent satisfies a condition to determine that the reagent is a genuine product based on the reagent information; and a controller that controls the display device to display both the numerical data and the distribution diagram if the reagent satisfies the condition by the determination section and to display the numerical data without displaying the distribution diagram if the reagent does not satisfy the condition by the determination section.Type: GrantFiled: September 12, 2008Date of Patent: July 29, 2014Assignee: Sysmex CorporationInventors: Toru Mizumoto, Ryuichiro Ebi, Keisuke Tsutsumida, Yousuke Tanaka, Junya Inoue
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Patent number: 8778687Abstract: A method and apparatus for determining the hematocrit of a blood sample disposed within an analysis chamber, the method including the steps of: a) imaging at least a portion of the sample that contains one or more red blood cells and one or more areas void of red blood cells; b) determining a representative optical density value for a plurality of image units optically aligned with portions of the red blood cells, and assigning an optical density first boundary value to those image units; c) determining a representative optical density value of a plurality of image units optically aligned with the one or more regions of the sample devoid of red blood cells, and assigning a second optical density boundary value to those image units; and d) determining the hematocrit of the sample.Type: GrantFiled: January 28, 2013Date of Patent: July 15, 2014Assignee: Abbott Point of Care, Inc.Inventors: Robert A. Levine, Stephen C. Wardlaw, Darryn Unfricht, Niten V. Lalpuria
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Publication number: 20140193921Abstract: A test apparatus and method for measuring a concentration of a target by correcting for an impact of hemoglobin are provided. The target measurement method includes measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample, determining variation of the absorbance of the target according to the measured absorbance of the hemoglobin, and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target.Type: ApplicationFiled: December 31, 2013Publication date: July 10, 2014Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Sung Hwa LEE, Takayuki TAGUCHI, Hye Kyung PARK
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Publication number: 20140162369Abstract: The present invention aims to provide a method of measuring hemoglobins which can measure hemoglobins in a short time at high accuracy. The present invention also aims to provide a method of measuring hemoglobin A1c, a method of simultaneously measuring hemoglobin A1c and hemoglobin F, a method of simultaneously measuring hemoglobin A1c and hemoglobin A2, and a method of simultaneously measuring hemoglobin A1c and abnormal hemoglobins, each utilizing the above-mentioned method of measuring hemoglobins by liquid chromatography. The present invention relates to a method of measuring hemoglobins by liquid chromatography. A column used in the method is filled with, as a column-packing material, cation-exchangeable particles including cross-linked polymer particles having a cation-exchange-group-containing polymer bonded to the surface of the cross-linked polymer particles, and the column shows a pressure value of 9.8×103 Pa or higher and 29.4×105 Pa or lower when an eluent for measurement is delivered at 1.Type: ApplicationFiled: January 11, 2012Publication date: June 12, 2014Applicant: SEKISUI MEDICAL CO., LTDInventor: Kazuyuki Oishi
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Patent number: 8748186Abstract: A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.Type: GrantFiled: December 22, 2009Date of Patent: June 10, 2014Assignee: Abbott LaboratoriesInventors: Richard Kendall, John W. Roche
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Publication number: 20140127670Abstract: A disposable blood analysis cartridge may include a sample collection reservoir, an absorbance measurement channel, and an optical light scattering measurement channel. One or more valves may be disposed between the sample collection reservoir and the absorbance measurement channel and/or the optical light scattering measurement channel. A negative pressure may be applied to the cartridge to pull sample from the sample collection reservoir through the one or more valves and into the absorbance measurement channel and/or the optical light scattering measurement channel. Once the sample is pulled into the absorbance measurement channel and/or the optical light scattering measurement channel, the one or more valves may be closed. With the one or more valves closed, and in some cases, a pusher fluid may be provided to push the fluid sample to other regions of the disposable fluid blood analysis cartridge.Type: ApplicationFiled: January 16, 2014Publication date: May 8, 2014Applicant: Honeywell International Inc.Inventors: Mark Kelley, Ron Bardell, Robert Janisch, Pamela Wong, Eric Peltola
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Patent number: 8702941Abstract: A method for analyzing hemoglobin by electrophoresis, capable of analyzing hemoglobin A1c (HbA1c) and modified hemoglobin with improved accuracy in a shortened analysis time is provided. The method for analyzing hemoglobin by electrophoresis includes performing electrophoresis under conditions in which an acidic substance having two or more carboxyl groups is present in an electrophoresis solution. At least two of the carboxyl groups of the acidic substance each have an acid dissociation constant (pKa) lower than the pH of the electrophoresis solution at the time of analysis.Type: GrantFiled: December 23, 2010Date of Patent: April 22, 2014Assignee: ARKARY, Inc.Inventors: Yusuke Nakayama, Satoshi Yonehara
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Patent number: 8703494Abstract: Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.Type: GrantFiled: May 20, 2010Date of Patent: April 22, 2014Assignee: Relia Diagnostic Systems, LLCInventors: William J. Rutter, Jang H. Han, Taewoo Kwon
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Patent number: 8679848Abstract: A collection device for use in connection with off-device testing of collected samples. The device includes a first panel having one or more apertures for receiving samples, a second panel opposite the first panel, and a removable tab having a first portion and a second portion. The first portion is aligned with at least one of apertures on the first panel and constructed such that depositing the sample through the at least one aperture causes the sample to be directly deposited on the first portion of the tab, and the second portion includes a sample-free grasping area accessible from an exterior of the device for removing the tab. A method of obtaining a sample is also disclosed.Type: GrantFiled: June 3, 2013Date of Patent: March 25, 2014Assignee: Immunostics, Inc.Inventor: Vincent P. LaStella
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Patent number: 8679847Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.Type: GrantFiled: October 22, 2012Date of Patent: March 25, 2014Assignee: Bayer Healthcare LLCInventor: Kevin Chang
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Patent number: 8679420Abstract: A device for testing a specimen comprising a first panel, a metering aperture structure having a plurality of metering apertures formed therein for receiving the specimen therethrough, a second panel opposite the first panel, a sheet disposed between the first and second panels, the sheet including a test area aligned with the plurality of metering apertures, a spacer element disposed between the first panel and the sheet, wherein the metering aperture structure is spaced away from the test area thereby improving readability of the testing. A method of manufacturing a specimen testing device is also disclosed.Type: GrantFiled: August 25, 2008Date of Patent: March 25, 2014Assignee: Immunostics, Inc.Inventors: Vincent P. LaStella, Kenneth Kupits
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Publication number: 20140072996Abstract: The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored blood sample or to identify a hemolyzed plasma sample. The present invention also relates to kits for use in the above described methods.Type: ApplicationFiled: November 20, 2013Publication date: March 13, 2014Applicant: ABBOTT LABORATORIESInventors: Maciej Adamczyk, Roy Jeffrey Brashear, Phillip G. Mattingly
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Patent number: 8663559Abstract: A sample analyzer that includes a sample preparing section operative to aspirate a sample from a sample container and a measuring section operative to prepare a plurality of measurement samples from the aspirated sample. A control unit is configured to sequentially measure the plurality of prepared measurement samples, obtain a plurality of measurement data for the respective measurement samples, and obtain an analysis result of a predetermined item of the sample based on the plurality of measurement data.Type: GrantFiled: March 28, 2008Date of Patent: March 4, 2014Assignee: Sysmex CorporationInventors: Masaharu Shibata, Noriyoshi Yoshida
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Patent number: 8637319Abstract: A method for detecting human or animal blood traces on a surface is described. The method is fundamentally based on the reaction of luminol and includes the preliminary operation of atomizing an inorganic powder suspension, such as titania, silica, alumina, hydroxyapatite, or the like, onto the surface to be investigated, after which a composition of luminol, a peroxidic oxidizing agent and an alkaline agent in an amount providing a pH within the range of 10 to 14, is atomized on the surface. A kit for carrying out the detection method of the invention is also described.Type: GrantFiled: December 2, 2009Date of Patent: January 28, 2014Assignee: Universita' Degli Studi di TorinoInventors: Gianmario Martra, Simone Priante, Marco Vincenti
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Patent number: 8623659Abstract: The present invention provides a method for determining sickle-cell zygosity in a subject. The method involves forming a first solution which includes a sample from the subject, a phosphate buffer, a detergent, and a reducing agent and subjecting the first solution to centrifugation to form a second solution and a supernatant; and taking a color reading of the supernatant and of the second solution; optionally filtering the second solution to form a filtrate and a precipitate, and optionally measuring the amount of the precipitation and the absorbance of the filtrate or taking a color reading of the filtrate.Type: GrantFiled: September 21, 2011Date of Patent: January 7, 2014Assignee: Saint Louis UniversityInventor: Tim R. Randolph
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Publication number: 20140004612Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.Type: ApplicationFiled: August 30, 2013Publication date: January 2, 2014Applicant: SYSMEX CORPORATIONInventors: Norimasa YAMAMOTO, Takashi YAMATO, Naohiko MATSUO, Satoshi IGUCHI
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Patent number: 8603828Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.Type: GrantFiled: November 8, 2010Date of Patent: December 10, 2013Assignee: Bio-Rad Laboratories, Inc.Inventors: Roger Walker, Benedicte Jardin
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Patent number: 8592219Abstract: A method for transporting in a microfluidic conduit an aliquot of a liquid, possibly containing a substance I, which is dissolved in the liquid and typically exhibits charged groups and/or hydrophobic groups. The method is characterized in that the liquid contains an amphiphilic macromolecular substance.Type: GrantFiled: January 20, 2005Date of Patent: November 26, 2013Assignee: Gyros Patent ABInventors: Rickard Kange, Mats Inganas, Magnus Gustafsson, Johan Engstrom, Bo Ek, Helene Dérand, Ann-Kristine Honerud
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Patent number: 8574913Abstract: Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system used in the method, a sample solution containing a blood component is treated with a nonionic surfactant, an oxidizing agent, and a metal salt to denature hemoglobin in the sample solution to measure the hemoglobin, and thereafter the amount of a hemoglobin derivative in the sample is measured by an immunological method using an antibody specifically binding to a denatured site of the denatured hemoglobin derivative.Type: GrantFiled: October 29, 2008Date of Patent: November 5, 2013Assignee: Panasonic CorporationInventors: Hirotaka Tanaka, Masanori Tanaka
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Patent number: 8563330Abstract: The invention provides a device and method for the rapid identification of patients suspected of having thalassemia. The invention provides a test strip for the aqueous detection of thalassemia related proteins in whole blood. The test strip includes antibodies specific to the gamma 4, (?4) protein and provides easy visual discrimination between a positive result and a negative result. The invention can be used in remote or clinical settings.Type: GrantFiled: March 21, 2008Date of Patent: October 22, 2013Assignee: National Science and Technology Development AgencyInventors: Watchara Kasinrerk, Chatchai Tayapiwatana, Thanusak Tatu, Suthat Fucharoen, Sawitree Chiampanichayakul
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Patent number: 8557590Abstract: A method for measuring glycated hemoglobin includes hemolyzing a blood sample with a hemolysate; reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials; measuring the amount of total hemoglobin in the reacted blood sample; isolating normal hemoglobin from the glycated hemoglobin conjugated with the bead conjugates; measuring the amount of glycated hemoglobin isolated from the normal hemoglobin; and determining the percentage of the glycated hemoglobin in the blood sample on the basis of the measured amounts of total hemoglobin and glycated hemoglobin. The isolation of normal hemoglobin is performed by absorbing the normal hemoglobin using an absorption pad that is a porous pad having pores, each of which has a size greater than the size of the normal hemoglobin and smaller than the size of the bead.Type: GrantFiled: December 19, 2011Date of Patent: October 15, 2013Assignee: Infopia Co., Ltd.Inventors: Byeong-Woo Bae, Sung-Dong Lee, Hyong-Soo Kim
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Patent number: 8557591Abstract: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.Type: GrantFiled: November 9, 2012Date of Patent: October 15, 2013Assignee: General AtomicsInventors: Chong-Sheng Yuan, Abhijit Datta, Limin Liu
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Publication number: 20130244263Abstract: The invention is directed to a method of identifying a patient undergoing periodic hemodialysis treatments at increased risk for death that includes determining at least one of the patient's clinical or biochemical parameters, consisting of serum bicarbonate concentration level, serum potassium concentration level, serum calcium concentration level, hemoglobin concentration level, serum phosphorus concentration level, neutrophil to lymphocyte ratio, equilibrated normalized protein catabolic rate (enPCR), equilibrated fractional clearance of total body water by dialysis and residual kidney function (eKdrt/V), EPO resistance index, transferrin saturation index, serum ferritin concentration level, serum creatinine concentration level, platelet count, Aspartat-Aminotransferase level, and Alanin-Aminotransferase level at periodic hemodialysis treatments, and identifying a patient as having an increased risk for death if the patient has a significant change in the rate of change of at least one of the patient's cliType: ApplicationFiled: December 1, 2011Publication date: September 19, 2013Inventors: Peter Kotanko, Stephan Thijssen, Len Usvyat, Nathan W. Levin
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Publication number: 20130202499Abstract: An occult blood detection composition is used for various applications including that of predicting the start of menstruation. The composition may be applied to various devices to create a sensor, such devices include a feminine pad or shield, a badge, a swab or a wipe. The composition may be part of a kit wherein one component of the composition is applied to a device for the consumer. The remaining component of the composition, in liquid form, is applied to the device by the consumer prior to use.Type: ApplicationFiled: January 29, 2013Publication date: August 8, 2013Applicant: Kimberly-Clark Worldwide, Inc.Inventor: Kimberly-Clark Worldwide, Inc.
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Publication number: 20130196443Abstract: A method and apparatus for dating a dating a body sample, such as blood, includes taking at least one spectroscopic measurement (37) of the sample at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined (41) from the measurement, and the measured relative concentrations of the two predetermined substances is compared (43) with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample (44).Type: ApplicationFiled: July 11, 2011Publication date: August 1, 2013Applicant: ACADEMISCH MEDISCH CENTRUMInventors: Maurice Aalders, Rolf Bremmer
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Patent number: 8497136Abstract: A device and method for detecting the presence of hemoglobin in a biological sample, more particularly, the presence of blood in a fecal sample as an indicator of upper or lower gastrointestinal tract bleeding.Type: GrantFiled: May 29, 2012Date of Patent: July 30, 2013Assignee: Quest Diagnostics Investments IncorporatedInventor: Howard Milne Chandler
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Patent number: 8492157Abstract: A microfluidic device and a method for measurement of biomaterials using the same. The microfluidic device includes a microfluidic structure including: a sample chamber which receives and accommodates blood; a reagent chamber which contains a luminescent reactant; a first detection chamber which contains a first material that is positively charged; a second detection chamber which is connected to the first detection chamber, and contains a second material having a boronate moiety; and at least one channel which connects the sample chamber, the reagent chamber and the first and second detection chambers.Type: GrantFiled: November 11, 2011Date of Patent: July 23, 2013Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei UniversityInventors: Jong Myeon Park, Won Yong Lee, Han Nim Choi, Jung Hoon Lee
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Patent number: 8465988Abstract: Methods are provided herein for determining antioxidant activity of a test sample in intact cells. The method includes determining the antioxidant capacity of a test sample in intact red blood cells, wherein the test sample is added to intact red blood cells and oxidative damage is measured by alteration of fluorescence intensity of an oxidation-sensitive fluorescent indicator dye.Type: GrantFiled: October 31, 2008Date of Patent: June 18, 2013Assignee: Natural Immune Systems, Inc.Inventor: Gitte S. Jensen
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Publication number: 20130149728Abstract: Provided are methods and devices used for determining the presence or absence of a contaminant in the sample of oral fluid. The method involves contacting a substrate having a detectable reporter with a sample of oral fluid and, based on determining a signal from the detectable reporter determining the presence or absence of a contaminant in the sample of oral fluid. The invention is useful for detecting lactose, milk, colostrum, blood, hemoglobin, whole cells, and combinations thereof. The method can be used for detecting oral contaminants in oral fluid samples obtained from any mammal, including neonatal ungulates.Type: ApplicationFiled: December 7, 2012Publication date: June 13, 2013Applicant: CYTOSIGNET, INC.Inventor: Cytosignet, Inc.
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Patent number: 8460938Abstract: A blood analyzing device (100) comprises a holder (110) for receiving a cuvette (20) with a blood sample (30). The device (100) induces a movement of the blood cells in the sample (30) by applying a field (230) over the cuvette (20). A detector (130) detects, based on output light from the blood sample (30) originating from a light source (120), a change in the induced movement of the cells caused by an increase in viscosity of the blood due to an aggregation and/or coagulation process. A processor (140) processes the detector reading and generates a signal representative of the hemostasis function of the tested blood.Type: GrantFiled: March 31, 2009Date of Patent: June 11, 2013Inventor: Tommy Forsell
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Patent number: 8449835Abstract: A devise for fecal occult blood test comprises a first and a second casings, a sampling portion extending from the first casing, a specimen processing portion, at least a testing portion and a packing cylindrical member. The packing cylindrical member is coupled between the first and second casings when unused and dismantled therefrom when used. After sampling via a specimen collecting portion of the sampling portion, the specimen collecting portion is drawn into the first casing to reduce the device size. The first and second casings are fixedly coupled together in a specimen processing position thereof to mix specimens with a liquid of the specimen processing portion into a testing liquid, and then in a specimen testing position thereof to disperse onto the testing portions for testing and directly display test results. The present invention advantages high accuracy, rather hygiene, significant size reduction, real-time testing-result display and convenient use.Type: GrantFiled: October 3, 2011Date of Patent: May 28, 2013Assignee: Taichung Veterans General HospitalInventor: Ming-Feng Wu
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Publication number: 20130130391Abstract: An object of the present invention is to provide a method for analyzing hemoglobins which can accurately separate hemoglobins in a short time by liquid chromatography. The present invention provides a method for analyzing hemoglobins by liquid chromatography which includes pre-treating a sample with an oxidant and a binder for trivalent heme iron.Type: ApplicationFiled: March 22, 2011Publication date: May 23, 2013Inventors: Hiroaki Taira, Takayuki Oka
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Patent number: 8440140Abstract: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.Type: GrantFiled: January 31, 2008Date of Patent: May 14, 2013Assignee: Sysmex CorporationInventors: Takaaki Nagai, Noriyuki Narisada, Daigo Fukuma
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Patent number: 8425839Abstract: A sample analyzer is disclosed that comprising: a first reagent container to hold a first reagent container with a first record section which contains a first reagent management information; a second reagent container holder to hold a second reagent container with a second record section which contains a second reagent management information; a first information reader; a second information reader; a registration section for registering the combination of the first reagent and the second reagent based on the first reagent management information; a measurement section for conducting a measurement of a predetermined analysis item by using the first reagent and the second reagent corresponding to the combination registered by the registration section; and a processing section for processing a measurement result obtained by the measurement section, and for obtaining an analysis result of the sample.Type: GrantFiled: March 28, 2008Date of Patent: April 23, 2013Assignee: Sysmex CorporationInventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
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Patent number: 8420399Abstract: A method for analyzing hemoglobin in a sample by separation analysis while suppressing the denaturation of the hemoglobin includes separating hemoglobin in the presence of at least one of a sulfurous acid compound and a dithionous acid compound.Type: GrantFiled: August 16, 2011Date of Patent: April 16, 2013Assignee: ARKRAY, Inc.Inventor: Yusuke Nakayama
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Patent number: 8389287Abstract: The present invention relates to methods for the collection of a sample from faecal material and, further, the detection of occult blood in or on the faecal material via the testing of the sample collected from the faecal material. The present invention also relates to collection methods comprising the use of a brush-like device having flexible or semi-flexible bristles wherein the brush-like device is contacted to the faecal material. The present invention also relates to detection of occult blood from the sample collected from the faecal material by means of a guaiac test or immunochromatographic test. The present invention additionally relates to the detection of one or more indicators of a pathological condition in or on the faecal material from which the sample is derived.Type: GrantFiled: April 10, 2006Date of Patent: March 5, 2013Assignee: Enterix PTY LimitedInventor: Howard Chandler
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Patent number: 8377392Abstract: An apparatus and method for sealing a fluid sample collection device, comprising loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates at an internal capillary stop; and slidably moving a sealing element over at least a portion of said substantially planar surface in a way that displaces any excess fluid sample away from the orifice, seals the fluid sample within said holding chamber, and inhibits the fluid sample from prematurely breaking through the internal capillary stop.Type: GrantFiled: June 8, 2012Date of Patent: February 19, 2013Assignee: Abbott Point of Care Inc.Inventors: Cary James Miller, Andy Maczuszenko
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Patent number: 8361390Abstract: The present invention relates to a liquid chromatography apparatus X, which is provided with a deaerator 4. The liquid chromatography apparatus X is further provided with a dissolved oxygen density adjusting means for maintaining a density of dissolved oxygen in an eluting solution to be supplied to a column 60 constant. Preferably, the dissolved oxygen density adjusting means is configured so as to adjust the density of the dissolved oxygen in the eluting solution by adjusting a degree of decompression in a decompression space of the deaerator 4 based on a measurement result by temperature measurement means 40A, 40B, and 40C for measuring the temperature of the eluting solution.Type: GrantFiled: February 8, 2007Date of Patent: January 29, 2013Assignee: Arkray, Inc.Inventors: Koji Sugiyama, Toshikatsu Sakai, Yoshikiyo Hongo, Akira Sezaki, Takanori Kamada
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Patent number: 8361799Abstract: A method for determining the hematocrit of a blood sample is provided that includes the steps of 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting optical density values of the image units aligned with the red blood cells; 4) selecting optical density values of the image units aligned with the one or more lacunae; and 5) determining the hematocrit of the sample using the selected optical density values of the image units aligned with the red blood cells and the lacunae.Type: GrantFiled: March 12, 2012Date of Patent: January 29, 2013Assignee: Abbott Point of Care, Inc.Inventors: Robert A. Levine, Stephen C. Wardlaw, Darryn Unfricht, Niten V. Lalpuria
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Patent number: 8338184Abstract: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.Type: GrantFiled: April 8, 2011Date of Patent: December 25, 2012Assignee: General AtomicsInventors: Chong-Sheng Yuan, Abhijit Datta, Limin Liu
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Patent number: 8318096Abstract: A wireless blood glucose meter is a battery-powered apparatus to communicating wirelessly with a portable terminal, and includes a blood glucose level detector that measures a blood glucose level, a transmitter that transmits the blood glucose level measured by the blood glucose level detector to the portable terminal, a receiver that receives a response signal sent from the portable terminal in response to the transmission of the blood glucose level by the transmitter to the portable terminal, and a voltage monitor that monitors the output voltage of the battery. A transmission control circuit changes the transmission method used by the transmitter on the basis of the output voltage of the battery as detected by the voltage monitor.Type: GrantFiled: December 8, 2008Date of Patent: November 27, 2012Assignee: Panasonic CorporationInventors: Eiji Okuda, Tooru Aoki, Norio Imai, Akiyoshi Oozawa
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Patent number: 8318501Abstract: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.Type: GrantFiled: November 11, 2010Date of Patent: November 27, 2012Assignee: General AtomicsInventors: Chong-Sheng Yuan, Abhijit Datta, Limin Liu
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Patent number: 8309357Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.Type: GrantFiled: January 22, 2008Date of Patent: November 13, 2012Assignee: Bayer HealthCare, LLCInventor: Kevin Chang
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Patent number: 8304244Abstract: What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and hemoglobin fractions, and, optionally, diagnostic for other blood analytes by sensor means.Type: GrantFiled: January 13, 2012Date of Patent: November 6, 2012Assignee: Instrumentation Laboratory CompanyInventors: Michael Pistorino, Prasad Pamidi
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Patent number: RE43795Abstract: The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine.Type: GrantFiled: October 9, 2002Date of Patent: November 6, 2012Assignee: ARKRAY, Inc.Inventors: Satoshi Yonehara, Tsuguki Komori
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Patent number: RE45074Abstract: The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine.Type: GrantFiled: October 16, 2012Date of Patent: August 12, 2014Assignee: ARKRAY, Inc.Inventors: Satoshi Yonehara, Tsuguki Komori