Ge, Sn, Pb Patents (Class 436/77)
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Patent number: 11712692Abstract: A biological sample collection system can include a sample collection vessel having an opening configured to receive a biological sample and a selectively movable valve configured to at least partially associate with the opening of the sample collection vessel. The selectively movable valve can include a post and a valve head associated with a distal portion of the post. The system can additionally include a sealing cap configured to associate with the selectively movable valve and with the sample collection vessel. The sealing cap can include a reagent chamber for storing a measure of sample preservation reagent and associating the sealing cap with the sample collection vessel causes a physical rearrangement of the post and the valve head such that a fluid vent associated with the post aligns with an aperture defined by the valve head allowing fluid communication between the reagent chamber and the sample collection vessel.Type: GrantFiled: November 20, 2019Date of Patent: August 1, 2023Assignee: Spectrum Solutions L.L.C.Inventors: Kevin Gregg Williams, Neil Jeremy Johnson
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Patent number: 11450518Abstract: A mass spectrometer includes: a target compound input receiving section for receiving an input of one or more target compounds; a measurement execution section for reading MRM measurement conditions, including a plurality of MRM transitions, respectively corresponding to the one or more target compounds from a storage section, and measuring the sample under the MRM measurement conditions; a measured multi-MRM spectrum creation section for creating a measured multi-MRM spectrum indicating an intensity of product ions as a mass peak on a graph having mass-to-charge ratios of the product ions on one axis, the intensity of the product ions acquired by measuring the sample; and a similarity degree calculation section for obtaining for each of the target compounds, a degree of similarity between standard multi-MRM spectrum stored in the storage section and the measured multi-MRM spectrum.Type: GrantFiled: March 23, 2017Date of Patent: September 20, 2022Assignee: SHIMADZU CORPORATIONInventor: Hiroyuki Yasuda
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Patent number: 11145044Abstract: The invention concerns in particular the analysis of a test device. After having obtained at least one image of a test device, the image comprising at least one representation of at least one portion of an observation surface and a visible reference having a predetermined format, the test device is identified according to the visible reference as well as a graphical element present in the portion of the observation surface. At least one geometrical feature of a graphical element identified according to at least the visible reference is then determined and the portion of the observation surface is analyzed according to an identification of the test device and at least one determined geometrical feature.Type: GrantFiled: April 15, 2019Date of Patent: October 12, 2021Assignee: PINQKERTONInventor: Christopher Pease
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Patent number: 9128075Abstract: A method of changing the response level for any chemical test kits designed for the determination of a metal or compound (such as lead) in paint and other media is disclosed. The invention solves two common problems that exist with using chemical test kits for the detection of lead in paint or other coatings and media: (1) conversion of the paint sample into particles small enough to dissolve the metal in the sample; and, (2) controlling the amount of (paint) sample that gets exposed to the chemicals. This is accomplished by using a coffee grinder or equivalent tool plus a solid (food) product to break up the paint sample into small particles and at the same time dilute the concentration of the metal, while in solid form, down to a level that results in obtaining a positive response at the desired concentration.Type: GrantFiled: June 30, 2012Date of Patent: September 8, 2015Inventors: Frederic G Dewalt, David C. Cox
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Patent number: 8765480Abstract: A method for recovering a metal, capable of recovering a metal easily without requiring the use of an organic medium, is provided. A first complex between a first chelating agent and a metal present in a sample is formed in a first mixture prepared by mixing the first chelating agent and the sample. Then, the first complex is recovered from the first mixture, and a second complex between the metal derived from the first complex and a second chelating agent is formed in a second mixture prepared by mixing the first complex and an aqueous solution of the second chelating agent. The aqueous solution is under the pH conditions where the first chelating agent can be insoluble in the aqueous solution. Then, a liquid fraction containing the second complex is recovered from the second mixture. Thus, the metal can be recovered.Type: GrantFiled: April 2, 2012Date of Patent: July 1, 2014Assignee: ARKRAY, Inc.Inventor: Yuka Shimomura
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Patent number: 8663992Abstract: Process for thermally stabilizing a polymer containing residues of a Sn(II), Sb(III), Pb(II), Bi(III), Fe(II), Ti(II), Ti(III), Mn(II), Mn(III), or Ge(II)-containing catalyst by treating the polymer at a temperature above its melting temperature with a peroxide selected from the group consisting of ketone peroxides, hydroperoxides, peracids, hydrogen peroxide, and mixtures thereof, wherein said peroxide is used in an amount less than 0.2 wt % based on the weight of the polymer and wherein the molar ratio of peroxy functionalities from said peroxide (p) to metal (M) ranges from 1 to 100; said metal (M) being selected from the group consisting of Sn(II), Sb(III), Pb(II), Bi(III), Fe(II), Ti(II), Ti(III), Mn(II), Mn(III), and Ge(II). The invention further relates to a method for determining the metal residue content of a polymer.Type: GrantFiled: July 8, 2009Date of Patent: March 4, 2014Assignee: Akzo Nobel N.V.Inventors: Andreas Herman Hogt, Wilhelm Klaas Frijlink
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Publication number: 20140004614Abstract: A method of changing the response level for any chemical test kits designed for the determination of a metal or compound (such as lead) in paint and other media is disclosed. The invention solves two common problems that exist with using chemical test kits for the detection of lead in paint or other coatings and media: (1) conversion of the paint sample into particles small enough to dissolve the metal in the sample; and, (2) controlling the amount of (paint) sample that gets exposed to the chemicals. This is accomplished by using a coffee grinder or equivalent tool plus a solid (food) product to break up the paint sample into small particles and at the same time dilute the concentration of the metal, while in solid form, down to a level that results in obtaining a positive response at the desired concentration.Type: ApplicationFiled: June 30, 2012Publication date: January 2, 2014Applicant: QUANTECH, INC.Inventors: Frederic G. Dewalt, David C. Cox
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Patent number: 8502136Abstract: A method for determining heavy metal loading in a subject includes collecting a saliva sample from the subject containing a concentration of a heavy metal. The saliva sample is subjected to inductively coupled plasma mass spectrometry to yield a heavy metal loading measurement for the subject. The saliva sample is readily collected on a substrate absorbing a preselected amount of saliva such as filter paper. As the amount of saliva necessary to saturate a given volume of substrate is known, the volume of saliva within a substrate is also known. The resulting heavy metal loading measurement is readily correlated with a blood level for the heavy metal in the subject.Type: GrantFiled: September 20, 2011Date of Patent: August 6, 2013Inventor: David Schneider
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Patent number: 8465979Abstract: A method for the detection of tin is presented. A specimen is first contacted with a ruthenium-containing species to create a contacted region of the specimen. At least a portion of the contacted region is then irradiated by an excitation radiation and monitored for a relaxation radiation emitted in response to the excitation radiation.Type: GrantFiled: February 24, 2011Date of Patent: June 18, 2013Assignee: General Electric CompanyInventor: Brent Allen Clothier
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Patent number: 8338553Abstract: Disclosed are a solvatochromic functional monomer having the chemical structure and a process for preparing the same. The solvatochromic functional monomer can be used for fabrication of molecularly imprinted polymer based (MIP-based) solvatochromic chemosensors. This involves the incorporation of the solvatochromic functional monomer as reporter into the molecularly imprinted polymer. The solvatochromic functional monomers as reporters signal the analyte-to-receptor displacing event within the receptor sites without the need for intermolecular interaction between the analyte and the receptor.Type: GrantFiled: July 1, 2009Date of Patent: December 25, 2012Assignee: City University of Hong KongInventors: Hon-Wah Lam, Chengbin Gong
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Patent number: 8263410Abstract: Disclosed is an innovative method for detecting metal ions based on selective plasmonic resonance energy transfer between metal-ligand complexes and a single nanoplasmonic particle as a probe. The selective plasmonic resonance energy transfer occurs if a resonance frequency matching condition between the single nanoplasmonic particle and the metal-ligand complexes is satisfied.Type: GrantFiled: July 30, 2009Date of Patent: September 11, 2012Assignees: Industry-University Cooperation Foundation Sogang University, University of California, BerkeleyInventors: Taewook Kang, Luke P. Lee, Yeonho Choi, Younggeun Park
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Patent number: 8232105Abstract: Certain embodiments described herein are directed to a reagent that includes an effective amount of an adsorber to remove interfering species present during heavy metal level measurement in a fluid sample. In some examples, the reagent can include an effective amount of an adsorber to remove a suitable amount of glutathione from the fluid sample such that the glutathione does not interfere with measurements of lead levels in the fluid sample.Type: GrantFiled: September 30, 2010Date of Patent: July 31, 2012Assignee: Magellan Biosciences Point-of-Care, Inc.Inventor: W James Scott
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Patent number: 8183049Abstract: With respect to a lead detection method that uses rhodizonic acid, it is made possible to clearly identify pink or red coloration caused by a reaction between lead and rhodizonic acid even in cases where Sn is present in a specimen. To this end, an acidic aqueous solution or a buffer solution thereof (e.g., tartaric acid) in which hydrogen peroxide coexists is used as a reagent. Hydrogen peroxide oxidizes Sn2+ into Sn4+. Since Sn4+ does not react with rhodizonic acid, the presence of Sn does not interfere with the visual identification of any pink or red coloration caused by the reaction between lead and rhodizonic acid.Type: GrantFiled: October 30, 2008Date of Patent: May 22, 2012Assignee: Toyota Jidosha Kabushiki KaishaInventors: Kengo Kayano, Naoki Sato, Shinichiro Hirayama
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Patent number: 8133739Abstract: To provide a lead concentration determination reagent which realizes accurate, high-sensitivity, and simple-manner determination of the lead ion concentration (also referred to simply as “lead concentration”) of a sample solution in the presence of calcium ions, and a lead concentration determination method employing the reagent. The lead concentration determination reagent contains (A) a water-soluble porphyrin derivative or a salt thereof, (B) at least one member selected from among polyacrylamide, polyvinyl alcohol, and polyethylene glycol, and (C) a calcium-ion-supplying compound.Type: GrantFiled: July 18, 2008Date of Patent: March 13, 2012Assignee: Kowa Co., Ltd.Inventor: Takaharu Asano
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Patent number: 8114673Abstract: This invention relates to an irreversible indicator for detecting oxidizing agents, or in particular an oxygen indicator, comprising at least one redox-sensitive dyestuff, at least one semiconductor material and at least one electron donor. This indicator is activated by exposure to light of about 200-400 nm. The invention also relates to UV light detector.Type: GrantFiled: September 2, 2002Date of Patent: February 14, 2012Assignee: University of StrathclydeInventors: Andrew Mills, Soo-Keun Lee
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Patent number: 8049165Abstract: A method for determining heavy metal loading in a subject includes collecting a saliva sample from the subject containing a concentration of a heavy metal. The saliva sample is subjected to inductively coupled plasma mass spectrometry to yield a heavy metal loading measurement for the subject. The saliva sample is readily collected on a substrate absorbing a preselected amount of saliva such as filter paper. As the amount of saliva necessary to saturate a given volume of substrate is known, the volume of saliva within a substrate is also known. The resulting heavy metal loading measurement is readily correlated with a blood level for the heavy metal in the subject.Type: GrantFiled: February 26, 2007Date of Patent: November 1, 2011Assignee: Coventry Diagnostics LLCInventor: David Schneider
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Patent number: 8012760Abstract: A system and associated methodology to directly measure the concentration of carbonate ions in seawater by ultraviolet absorbance spectroscopy. Metal ions are added to seawater and the absorbance spectra of the added ions are measured in the ultraviolet. The spectral absorbance (light attenuation) of ions such as divalent lead or copper in seawater is predominantly determined by the carbonate ion content of seawater. Through a knowledge of (1) the strength of association between carbonate and either divalent lead or divalent copper and (2) the spectral characteristics of these cations in seawater (e.g., Pb2+ complexed solely as PbCO3 and Pb2+ complexed solely in the form of chloride complexes), it is possible to directly determine seawater carbonate ion concentrations from absorbance measurements at a variety of wavelengths in the ultraviolet.Type: GrantFiled: October 26, 2010Date of Patent: September 6, 2011Assignee: University of South FloridaInventor: Robert H. Byrne
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Patent number: 7960177Abstract: A standard calibration set having at least three calibration standards. Each standard is a molded article made of a thermoplastic polymer which contains the elements Cd, Cr, Pb, Hg and Br, with the Cr:Pb:Hg:Br:Cd ratio being different in each of the three calibration standards. Further disclosed is a method for manufacturing the calibration standards and their use in X-ray fluorescence analysis.Type: GrantFiled: November 10, 2006Date of Patent: June 14, 2011Assignee: Fachhochschule MünsterInventors: Martin Kreyenschmidt, Christian Mans, Stephanie Hanning
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Patent number: 7927879Abstract: Proposed is a zirconium crucible used for melting an analytical sample in the pretreatment of the analytical sample, wherein the purity of the zirconium crucible is 99.99 wt % or higher. In light of the recent analytical technology demanded of fast and accurate measurement of high purity materials, the present invention provides a zirconium crucible for melting an analytical sample, a method of preparing such analytical sample, and a method of analysis that enables the analysis of high purity materials by inhibiting the inclusion of impurities from the crucible regardless of difference in the analysts and their skill.Type: GrantFiled: February 20, 2007Date of Patent: April 19, 2011Assignee: JX Nippon Mining & Metals CorporationInventors: Masahiro Sakaguchi, Mitsuru Yamaguchi, Tomio Takahashi, Kouichi Takemoto
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Patent number: 7842507Abstract: A system and associated methodology to directly measure the concentration of carbonate ions in seawater by ultraviolet absorbance spectroscopy. Metal ions are added to seawater and the absorbance spectra of the added ions are measured in the ultraviolet. The spectral absorbance (light attenuation) of ions such as divalent lead or copper in seawater is predominantly determined by the carbonate ion content of seawater. Through a knowledge of (1) the strength of association between carbonate and either divalent lead or divalent copper and (2) the spectral characteristics of these cations in seawater (e.g., Pb2+ complexed solely as PbCO3 and Pb2+ complexed solely in the form of chloride complexes), it is possible to directly determine seawater carbonate ion concentrations from absorbance measurements at a variety of wavelengths in the ultraviolet.Type: GrantFiled: April 28, 2008Date of Patent: November 30, 2010Assignee: University of South FloridaInventor: Robert H. Byrne
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Patent number: 7829340Abstract: Methods for measuring the concentration of heavy metals such as lead in oral fluid are provided. The concentration of lead in oral fluid can be accurately correlated with the concentration of lead in the blood serum. The methods are useful for, among other things, diagnosis and monitoring of heavy metal exposure.Type: GrantFiled: July 28, 2008Date of Patent: November 9, 2010Assignee: OFT Labs, LLCInventors: Eugene E. Elwell, Robyn Hannigan, Edward Eckert
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Patent number: 7816142Abstract: A system for testing multiple samples for the presence of lead includes a plurality of vessels, a plurality of plungers, a housing for removably storing the plurality of vessels, and a retainer for holding the plurality of plungers so that each of the plungers may be inserted into a respective vessel simultaneously. In order to use the system of the present invention, a sample is placed within each of the plurality of vessels and a reagent, such as nitric acid, is added to each sample. Each sample is then heated in a separate heating device and a filtering means, such as a cotton ball, is inserted into each vessel. Each plunger then pushes its respective cotton ball into its respective vessel simultaneously so that each liquid sample is located adjacent the top of each vessel. The plungers are removed and the housing is then placed into an analyzer.Type: GrantFiled: April 29, 2008Date of Patent: October 19, 2010Assignee: EMSL Analytical, Inc.Inventor: Peter Frasca
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Patent number: 7749765Abstract: The present invention provides compositions and methods for extracting, isolating, and measuring lead dissolved in aqueous solutions, including water.Type: GrantFiled: August 3, 2006Date of Patent: July 6, 2010Assignee: University of Virginia Patent FoundationInventors: James N. Demas, Wenying Xu
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Patent number: 7732218Abstract: There is provided a method for preparing an analytical standard used for microbeam X-ray fluorescence analysis which includes: a mixing step in which an element is added to a base material, and the base material and the element are mixed by stirring to obtain a mixed solution; a deaeration step in which the mixed solution is deaerated; a freeze step in which the mixed solution is slowly frozen; and a cutting step in which a thin section is cut out from the frozen mixed solution. In order to surely remove bubbles from the mixed solution, the deaeration step may contain a stationary step in which the mixed solution is allowed to stand still at room temperature; or the stationary step includes a removal step in which gas contained in the mixed solution which is allowed to stand still is removed with a suction apparatus.Type: GrantFiled: October 2, 2007Date of Patent: June 8, 2010Assignee: National Institute of Radiological SciencesInventors: Shino Takeda, Masae Yukawa, Yoshikazu Nishimura
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Publication number: 20100112706Abstract: An analytical technique for determining the structures of serotonin transporter (SERT) imaging agent [123I] ADAM and its precursor, SnADAM by using a high-performance liquid chromatography tandem mass spectrometer (LC-MS/MS) is provided. An analytical technique for determining the purity of SnADAM by using a high-performance liquid chromatograph (HPLC) is also provided.Type: ApplicationFiled: October 23, 2009Publication date: May 6, 2010Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: Kung-Tien Liu, Han-Hsing Yang, Yi-Chih Hsia, Chang-Yung Su, Tai-Sheng Lin, Chia-Chieh Chen, Lie-Hang Shen
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Patent number: 7615377Abstract: The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.Type: GrantFiled: August 27, 2004Date of Patent: November 10, 2009Assignee: Massachusetts Institute of TechnologyInventors: Stephen J. Lippard, Elizabeth Marie Nolan
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Publication number: 20080299664Abstract: A reagent for lead assay whereby a lead concentration can be accurately assayed even if an analyte contains calcium ions, and a method for assaying the lead concentration using the reagent for lead assay are provided. The reagent for lead assay contains a porphyrin nucleus-incorporated polymer, which is obtained by radical copolymerization of a porphyrin compound with a vinylene monomer, and calcium ions.Type: ApplicationFiled: July 28, 2005Publication date: December 4, 2008Applicant: Kowa Co., Ltd.Inventors: Takaharu Asano, Naoki Harada
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Publication number: 20080280366Abstract: The present invention provides compositions and methods for extracting, isolating, and measuring lead dissolved in aqueous solutions, including water.Type: ApplicationFiled: August 3, 2006Publication date: November 13, 2008Inventors: James N. Demas, Wenying Xu
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Patent number: 7273588Abstract: Methods for determining the amount of at least one metal analyte present in a liquid or gas sample of a halosilane supply (e.g., a chlorosilane supply) are disclosed herein. A sample of a halosilane supply is contacted and reacted with an aqueous hydrofluoric acid solution to produce a liquid reaction mixture. Liquid from the liquid reaction mixture is evaporated under controlled temperature and pressure conditions to near dryness. The nearly-dry residue is prepared for spectral analysis. The presence of a detectable amount of at least one metal analyte is determined for the sample.Type: GrantFiled: July 17, 2003Date of Patent: September 25, 2007Assignee: Air Liquide America L.P.Inventors: Daniel C. Cowles, David S. Bollinger
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Patent number: 6875615Abstract: The present invention relates to sensors for the determination of organometallic compounds comprising the following elements: a) an inorganic, organic or polymeric support, insoluble in the sample to analyze b) an indicator which reversibly reacts with the organometallic compound and whose reaction product gives a characteristic absorption, reflection or emission band in the range 150-15000 nm and which is physically trapped, adsorbed, absorbed, dissolved or chemically linked in an electrostatic or covalent way to the support c) an optical sensor which measures the absorption, reflection or emission of the functionalized support at the characteristic wavelength and transforms it in the concentration of the organometallic present in the solution. Also described is the method for the determination of the concentration of organometallic compounds by the on line use of a sensor as above defined.Type: GrantFiled: April 17, 2002Date of Patent: April 5, 2005Assignee: Dynasol Elastomeros, S.A.Inventors: Luisa Maria Fraga Trillo, Valentin Ruiz Santa Quiteria, Guillermo Orellana Moraleda, Ana Maria Castro Franco
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Patent number: 6800485Abstract: A one-step chemical spot test for the qualitative determination of lead in lead-based paint and other media. This test is based upon the reaction of lead with sodium rhodizonate under strong acid conditions to develop an intense purple colored complex. The acid preferred is dilute hydrochloric acid. The test is performed in one step using a dropper, plastic cylinders, or like apparatus.Type: GrantFiled: May 14, 2003Date of Patent: October 5, 2004Inventor: Sandra Lynn Cole
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Publication number: 20030203496Abstract: A one-step chemical spot test for the qualitative determination of lead in lead-based paint and other media. This test is based upon the reaction of lead with sodium rhodizonate under strong acid conditions to develop an intense purple colored complex. The acid preferred is dilute hydrochloric acid. The test is performed in one step using a dropper, plastic cylinders, or like apparatus.Type: ApplicationFiled: May 14, 2003Publication date: October 30, 2003Inventor: Sandra Lynn Cole
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Publication number: 20030186454Abstract: A method is disclosed for performing drug lead profiling assays for drug discovery utilizing a nanocalorimeter. The method includes depositing not less than one drop containing a profile molecule solution to be screened and not less than one drop containing a drug library compound on a test substrate. After the drops are merged, a determination is made as to whether a reaction has occurred.Type: ApplicationFiled: November 22, 2002Publication date: October 2, 2003Applicant: Xerox CorporationInventors: Richard H. Bruce, Steven Rosenberg
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Publication number: 20030153091Abstract: An article for delivery of a chemical reactant includes a liquid or solvated chemical reactant pre-moistened into an applicator. A chemical reactant impervious package has a pouch adapted to enclose the applicator for storage. The chemical reactant delivery article is based on capillary action to wick the continuing supply of chemical reactant to the substrate contacting portion of the applicator and as such is operative independent of chemical reactant gravitational flow.Type: ApplicationFiled: February 11, 2002Publication date: August 14, 2003Inventors: Dean M. Willard, Mark W. Feist, Hans E. Haas, Marcia Snyder, Jonathan D. Zook
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Publication number: 20030064529Abstract: A portable instrument for automatic collection and analysis of airborne lead concentrations in ambient air environments. Its improvements to the art of airborne lead detection and analysis permit the apparatus to analyze samples previously collected by personal monitors, for example, worn on the clothing of personnel working in contaminated sites. The apparatus also brings to the art of lead analysis a method of contaminant collection that ensures a greater capture efficiency of airborne contaminants, thereby increasing the accuracy of the instrument and its measurement capabilities while providing near real-time analysis and measurement in a portable self-contained battery-powered device. The apparatus also offers a remarkable improvement in the reduction of wastes incurred in the collection and analysis of airborne lead contaminants which is a novel method of concentrating the samples and recycling the analysis media used to concentrate and solubilize lead contaminants.Type: ApplicationFiled: October 1, 2001Publication date: April 3, 2003Inventors: Clifford Jolly, Leslie A. Karr, Bryan Lee Harre, Barbara Marie Sugiyama, John Joseph Kornuc
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Publication number: 20030049852Abstract: A one-step chemical spot test for the qualitative determination of lead in lead-based paint and other media. This test is based upon the reaction of lead with sodium rhodizonate under strong acid conditions to develop an intense purple colored complex.Type: ApplicationFiled: August 12, 2002Publication date: March 13, 2003Inventor: Sandra Lynn Cole
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Publication number: 20030008404Abstract: Disclosed is a program for measuring the impurity in semiconductor wafer, comprising an instruction for supplying to a computer a reference dose, an instruction for causing the computer to convert each of a plurality of impurity profiles measured in a direction of depth of the semiconductor wafer into a dose, and an instruction for causing the computer to select a converted dose closest to the reference dose from the plurality of converted doses.Type: ApplicationFiled: June 14, 2002Publication date: January 9, 2003Inventors: Mitsuhiro Tomita, Shoji Kozuka, Tetsuya Tachibe, Masamichi Suzuki
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Publication number: 20020187558Abstract: The present invention is a colorimetric method, and kit therefore, for determining the level of elemental contaminants in a water source. In a preferred embodiment, the method comprises: (a) sampling a discrete amount of water to be tested, (b) contacting the water sample with a solid material having high specificity for reversibly binding to, or complexing with, the element to be detected, (c) separating the element-containing solid from the water sample, (d) eluting the element from the element-containing solid with an eluting solution, (e) adding a cation-containing solution capable of freeing the element to be detected from the eluting compound, (f) adding a buffer, (g) adding a colorimetric material capable of indicating the amount of metal present in the solution, (h) adding an oxidation-fixing reagent, and (i) estimating the amount of metal in the sample by comparing the solution to provided color standards.Type: ApplicationFiled: June 5, 2001Publication date: December 12, 2002Applicant: Advanced Exploration & Research, Inc.Inventors: Joseph B. Bodkin, Hubert L. Barnes
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Patent number: 6492180Abstract: A method and apparatus for non-invasive extraction and/or detection of chemicals such as heavy metals, drugs such as cocaine and analytes such as blood glucose has been developed. A patch or hydrogel containing a reagent such as N-methyl pyrrole, or a similar compound, is used to extract the chemical or analyte to be measured through the skin or hair. This method is most useful for detecting analytes which are generally present in relatively constant blood concentrations. The method is particularly useful for the detection of heavy metals such as lead, lithium, copper, iron, and has been demonstrated to be useful with drugs such as cocaine and acetominaphen, and metabolic analytes like blood glucose. In the preferred embodiment, the method involves the use of the water miscible solvent N-methyl pyrrolidone (NMP) in an aqueous solution which is incorporated into an adsorbent pad or hydrogel.Type: GrantFiled: June 24, 1999Date of Patent: December 10, 2002Assignee: Transderm Technologies LLCInventors: Larry R. Brown, Elazer Edelman, David Tseng
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Patent number: 6489170Abstract: A one-step chemical spot test for the qualitative determination of lead in lead-based paint and other media. This test is based upon the reaction of lead with sodium rhodizonate under strong acid conditions to develop an intense purple colored complex. The acid preferred is dilute hydrochloric acid. The test is performed in one step using a dropper, plastic cylinders, or like apparatus.Type: GrantFiled: June 18, 1999Date of Patent: December 3, 2002Inventor: Sandra Lynn Cole
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Patent number: 6346418Abstract: A method for evaluating ratios of metallic impurities in lithographic materials is disclosed. The method comprises: separating said metal from said lithographic material by microwave heating; then adding said metal to an acid to form a solution; and finally analyzing said solution by a instrument to measure ratio of said metal.Type: GrantFiled: September 2, 1999Date of Patent: February 12, 2002Assignee: Mosel Vitelic Inc.Inventors: Hui-An Chang, Bor-Jen Cheng, Yu-Chuan Lin
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Patent number: 6323036Abstract: The present invention provides a reagent for extracting lead ions from a variety of biological matrices such as human whole blood that has been anticoagulated with either heparin or EDTA, and lyophilized human blood and bovine EDTA whole blood. The released lead is measured in situ with a calorimetric porphyrin reagent without further manipulation of the supernatant. The lead ion releasing reagent can be used in conjunction with a variety of assay formats for the determination of lead in various biological fluids.Type: GrantFiled: May 27, 1998Date of Patent: November 27, 2001Assignee: Bayer CorporationInventors: Eddy Chapoteau, Bronislaw P. Czech, Jonathan Craine
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Patent number: 6248593Abstract: A method of detecting lead contamination of a surface is disclosed. A handwipe issued to collect any lead contamination on the surface. The lead is solubilized with an aqueous acid solution and treated with rhodizonate or sulfide anions. A change in color from pink to red, where rhodizonate anions are used, or brown to black, where sulfide anions are used, is indicative of the presence of lead. The method is suitable for testing surfaces such as floors, walls, windowsills, and human skin.Type: GrantFiled: December 9, 1999Date of Patent: June 19, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Eric J. Esswein, Mark Boeniger, Kevin Ashley
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Patent number: 6248592Abstract: Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze ≦1 &mgr;L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 &mgr;L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.Type: GrantFiled: March 27, 1995Date of Patent: June 19, 2001Assignee: The Regents of the University of CaliforniaInventor: Nicholas S. Nogar
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Patent number: 6228651Abstract: A process for the preparation of an analytical sample characterized by depositing and separating solely the impurity to be analyzed from phosphoric acid; a process for analysis of the impurity characterized by depositing and separating solely the impurity from phosphoric acid and applying the separated material to analysis; a process for preparation of high grade phosphoric acid characterized by depositing and separating solely the impurity from phosphoric acid to be purified; a process for the fabrication of a semiconductor device characterized by using phosphoric acid, the impurity content of which is not more than 10−3 Bq/mL, defined by the concentration of a contained radioactive element selected from the group consisting of Pb, Bi and Po, as a processing solution.Type: GrantFiled: December 30, 1998Date of Patent: May 8, 2001Assignee: Fujitsu LimitedInventors: Hiroyuki Fukuda, Takashi Nakanishi, Mitsuru Hirose
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Patent number: 6225127Abstract: This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bound to the macromolecule.Type: GrantFiled: March 15, 1999Date of Patent: May 1, 2001Assignee: University of Maryland, BaltimoreInventors: Richard B. Thompson, Marcia W. Patchan, Zhenfang Ge
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Patent number: 6225128Abstract: A package comprises a sealed plastic envelope containing a small amount of desiccant sufficient to absorb the moisture in the air entrapped in the envelope. The package contains a dry test card having at least one circular area coating of a dry solid rhodizonic acid dipotassium chromogen salt free of any solvent.Type: GrantFiled: February 19, 1999Date of Patent: May 1, 2001Assignee: WRS and AssociatesInventor: Kenneth T. White
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Patent number: 6171552Abstract: The present invention provides for a hydride formation analytical apparatus which forms hydrides of target components contained in a sample liquid and then analyzes them. The hydride formation analytical apparatus comprises a sample-introducing part, a reagent-introducing part, a reaction part, a gas-liquid separating part and a detecting part, wherein an acid-feeding part and a reducing agent-feeding part are part of the reagent-introducing part; the hydride gas of the sample is formed by the aid of the acid and the reducing agent fed into the above reaction part; and this is introduced into the detecting part for analysis.Type: GrantFiled: January 30, 1998Date of Patent: January 9, 2001Assignee: Mitsubishi Materials CorporationInventors: Minoru Takeya, Yutaka Hayashibe, Kazutoshi Shimura
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Patent number: 6037182Abstract: A method is used to detect a location of contaminant entry in a processing fluid production and distribution system. A wafer is placed in a clean container. The clean container is connected to a test point within the processing fluid production and distribution system. Processing fluid from the test point of the processing fluid production and distribution system is allowed to flow through the clean container. The wafer is dried. The wafer is then tested for the existence of contaminants.Type: GrantFiled: December 29, 1997Date of Patent: March 14, 2000Assignee: VLSI Technology, Inc.Inventor: John A. Weems
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Patent number: 5952236Abstract: This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bound to the macromolecule.Type: GrantFiled: October 25, 1996Date of Patent: September 14, 1999Inventors: Richard B. Thompson, Marcia W. Patchan, Zhengfang Ge