Abstract: Methods, apparatuses, and kits for detection of substances in water by forming a complex with an indicator reagent and filtering the complex on a filter or membrane are described. The concentrated indicator on the filter, membrane or other capture device provides a colorimetric readout that can determine the amount of substance present in a water sample. A computer-implemented method for determining the concentration of substances in water based on color data from the colorimetric readout is also described.
Abstract: A trace analyte collection swab having a collection surface at least partially coated with a microscopically tacky substance to enhance pick-up efficiency is described. In embodiments, the truce analyte collection swab comprises a substrate including a surface having a trace analyte collection area and a coating disposed on the surface of the substrate in the trace analyte collection area. The coating is configured to be microscopically adhesive to collect particles of the trace analyte from a surface when the trace analyte collection area is placed against the surface. In one embodiment, the coating comprises Polyisobutylene.
Type:
Grant
Filed:
August 9, 2019
Date of Patent:
November 22, 2022
Assignee:
Smiths Detection Montreal Inc.
Inventors:
Paul Christopher Peter Thomson, Atin J. Patel
Abstract: A method using ascorbic acid (Vitamin C) as part of a chemical test kit employing sodium rhodizonate as the coloring agent for producing a yellow-orange to purple color transition for detection of lead in various media eliminating the use of strong acid.
Abstract: Processes, compositions, and sensors for sensing a variety of toxic chemicals based on colorimetric changes. Exemplary process for sensing a toxic chemical includes contacting a toxic chemical, or byproduct thereof, with a sorbent that includes a porous metal hydroxide or a porous mixed-metal oxide/hydroxide and a transition metal reactant suitable to react with a toxic chemical or byproduct thereof. The sorbent is contacted with the toxic chemical or byproduct thereof for a sampling time. A difference between a post-exposure colorimetric state of the sorbent and a pre-exposure colorimetric state of the sorbent is determined to thereby detect exposure to, or the presence of, the toxic chemical or byproduct thereof.
Type:
Grant
Filed:
July 29, 2020
Date of Patent:
August 2, 2022
Assignee:
The United States of America as Represented by the Secretary of the Army
Inventors:
Jennifer R Soliz, Darren K Emge, Ian J Pardoe, Gregory W Peterson
Abstract: Processes, compositions, and sensors for sensing a variety of toxic chemicals based on colorimetric changes. Exemplary process for sensing a toxic chemical includes contacting a toxic chemical, or byproduct thereof, with a sorbent that includes a porous metal hydroxide or a porous mixed-metal oxide/hydroxide and a transition metal reactant suitable to react with a toxic chemical or byproduct thereof. The sorbent is contacted with the toxic chemical or byproduct thereof for a sampling time. A difference between a post-exposure colorimetric state of the sorbent and a pre-exposure colorimetric state of the sorbent is determined to thereby detect exposure to, or the presence of, the toxic chemical or byproduct thereof.
Type:
Grant
Filed:
July 30, 2020
Date of Patent:
July 12, 2022
Assignee:
The United States of America as Represented by the Secretary of the Army
Inventors:
Jennifer R Soliz, Darren K Emge, Ian J Pardoe, Gregory W Peterson
Abstract: A method for detecting material in a sample using an ICP instrument includes preparing the sample for analysis by the ICP instrument using hydrogen gas. For example, hydrogen gas can be generated by initiating a hydride generation reaction with the sample. Further, hydrogen gas can be introduced to a component part of the sample. For instance, hydrogen gas can be added to an injector gas in a spray chamber of the ICP instrument.
Abstract: A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.
Abstract: A method of determining beryllium or a beryllium compound in a sample is disclosed by measuring fluorescence. This method discloses use of highly strong acids to extract beryllium from samples into the acidic medium, and then using these solutions in combination with highly alkaline fluorescent indicating dye solutions to determine the amount of beryllium in the samples.
Type:
Grant
Filed:
December 19, 2019
Date of Patent:
October 12, 2021
Assignee:
AJJER L.L.C.
Inventors:
Anoop Agrawal, Lori Adams, John P. Cronin
Abstract: In one embodiment the present invention describes a test kit for detecting arsenic concentration in a sample. The test kit includes a stable bromide compound capable of being made into a solution comprising bromine, a dye, wherein the bromine to the dye ratio is in a range from about 4:1 to about 5:1, an acid, and a quantification system for detecting the concentration of arsenic in the sample. In another embodiment the present invention describes a test kit for detecting a concentration of up to 0.03 parts per million of arsenic in a sample. A method of using the test kit to detect concentration of arsenic in a sample is also described.
Type:
Grant
Filed:
March 7, 2019
Date of Patent:
June 1, 2021
Inventors:
Ankush Kundan Dhawan, Jeffery William Seyler, Sr.
Abstract: The present invention provides an omniphobic membrane and application thereof. The omniphobic membrane comprises a porous substrate which has a pore size between 0.4 and 2 ?m, a top coat, and an interface layer between the porous substrate and the top coat, and the omniphobic membrane has a carbon/silicon ratio between 40 and 60, and a hierarchical re-entrant structure. Furthermore, both of a process for fabricating the omniphobic membrane and a method for desalination of a liquid by membrane distillation are provided in the present invention.
Abstract: The application relates to methods of analyzing luminescent species. A substrate is provided that has a plurality of zero mode waveguides having apertures that extend through an upper non-reflective layer that is disposed on a lower transparent layer of a substrate. The apertures have non-reflective oxide layers on the reflective side walls of the apertures, the side walls having a thickness of greater than 10 nm, and the oxide layer is formed by oxidizing the non-reflective layer. The volume within the oxide layer defines a solution volume, and the volume within the reflective walls defines a ZMW volume. Having such non-reflective layers on the walls of the ZMW usefully decouples the solution volume from the ZMW volume.
Abstract: The invention generally relates to novel fluorophore-labeled, bi- or multi-functional, chemically reactive and/or biologically active conjugates, and related compositions and methods thereof.
Abstract: An embodiment provides a method for measuring aluminum concentration in an aqueous sample, including: preparing a chromeazurol S indicator solution; placing the chromeazurol S indicator solution in a sample containing aluminum, wherein the placing causes the chromeazurol S to chelate aluminum within the sample creating a colored complex; and measuring, using colorimetric techniques, a concentration of aluminum within the sample, wherein the measuring comprises measuring an absorbance at a wavelength for the colored complex. Other embodiments are described and claimed.
Type:
Grant
Filed:
February 15, 2019
Date of Patent:
October 6, 2020
Assignee:
Hach Company
Inventors:
Melanie Ann Roth, Angella NIcholle Greenawalt
Abstract: A method of determining beryllium or a beryllium compound thereof in a sample is disclosed by measuring fluorescence. This method discloses use of highly alkaline fluorescent indicating dye solutions with pH greater than 12.9. In a preferred embodiment the fluorescent indicating dye solutions do not contain a pH buffer. Further, the method also discloses measuring fluorescence under highly alkaline conditions, where the pH after mixing the highly alkaline fluorescent indicating dye solutions with the sample solution containing beryllium is at least 11, preferably 12. The use of highly alkaline solution provides superior detection limits for beryllium by using dilution ratios of 4× and lower.
Type:
Grant
Filed:
May 26, 2016
Date of Patent:
February 11, 2020
Assignee:
AJJER L.L.C.
Inventors:
Anoop Agrawal, Lori Adams, John P. Cronin
Abstract: Novel Zr-based metal-organic framework (MOF) chemosensors useful for detection, recognition, removal, and separation of heavy metals are provided. Also provided are methods for preparation of the chemosensors and processes for detection, recognition, removal, and separation of heavy metals using the chemosensors.
Type:
Grant
Filed:
February 11, 2014
Date of Patent:
January 8, 2019
Assignee:
THE AMERICAN UNIVERSITY IN CAIRO
Inventors:
Hassan Azzazy, Ahmed Shahat, Hassan M. A. Hassan
Abstract: The disclosure is directed to a surface having a binding component applied thereto for the adsorption or capture of pathogens and organic molecules or materials. The surface may be a component of a porous or nonporous substrate. The binding component may also bind a photocatalyst to the surface for photocatalytic destruction of the captured pathogens and organic molecules or materials.
Type:
Grant
Filed:
December 19, 2012
Date of Patent:
December 18, 2018
Assignee:
National Technology & Engineering Solutions of Sandia, LLC
Abstract: Various methods for separating a metal from its metal oxide for analysis are provided. For example, exemplary methods include approaches for providing a process for separating a metal from its water-soluble metal oxide in a pyrotechnic composition. Exemplary embodiments include a method of separation that allows for analysis of both metal and metal oxide using an elemental analysis technique, (e.g., inductively coupled plasma optical emission spectrometry (ICP-OES)) and determination of the relative amount of elemental metal and its oxide known as speciation.
Type:
Grant
Filed:
September 9, 2016
Date of Patent:
November 20, 2018
Assignee:
The United States of America, as represented by the Secretary of the Navy
Inventors:
Douglas M. Papenmeier, Steven M. Lovejoy, Henry Ye
Abstract: In a method of resolving a contribution ratio to soil contamination by a plurality of polluters through a sequential extraction scheme and a stable isotope analysis scheme, Pb stable isotopes are eluted at 5 types of “cation exchange fraction”, “carbonate fraction”, “iron-oxide and manganese hydroxide-fraction”, “organic matters and sulfide fraction”, and “residual fraction” existing at other types and separated from each other in each step. The Pb stable isotopes obtained in each step are analyzed. The contribution ratio to soil contamination by the polluters is resolved through a predetermined resolving equation using the content of a Pb stable isotope in each step based on the content ratio of the Pb stable isotopes. The Pb stable isotopes are 206Pb and 207Pb.
Type:
Grant
Filed:
December 28, 2015
Date of Patent:
September 4, 2018
Assignee:
KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCE
Abstract: The invention generally relates to novel fluorophore-labeled, bi- or multi-functional, chemically reactive and/or biologically active conjugates, and related compositions and methods thereof.
Abstract: Hydroxyphenylbenzazole compounds that are useful for the selective detection of zinc, aluminum, chromium, and iron cations in vitro and in vivo. The Hydroxyphenylbenzazole compounds include a 2-hydroxyphenyl group bound to a single benzazole group; a first ligand group that is a Schiff base moiety; and a second ligand group selected from a Schiff base moiety and a hydroxyl group.
Abstract: A lubricating oil composition for refrigerating machines contains a base oil and an additive in a form of a naphthalimide compound. A refrigerant used in a refrigerating machine in which the composition is used is unsaturated hydrofluorocarbon (unsaturated HFC) having a GWP of 1000 or less. When the present lubricating oil composition for refrigerating machines is used in refrigerating equipment such as an open-type automobile air-conditioner, an electric automobile air-conditioner, a gas heat pump, other air-conditioning equipment, a refrigerating machine, a vending machine, a showcase, a water-heating system and a refrigerating/heating system, it is possible to detect the leakage of a refrigerant with a long-lasting stability. Therefore, when an unsaturated fron refrigerant with a poor stability is used in the above-listed equipment, the present lubricating oil composition for refrigerating machines is significantly advantageous.
Abstract: A method of detecting Hg2+ in an aqueous solution. The method includes contacting the aqueous solution with a composition containing a plant extract and biosynthesized silver nanoparticles. The composition has an average particle size of 30-50 nm. A color change following the contacting indicates the presence of Hg2+ in the aqueous solution. The composition is preferably synthesized by reduction of a silver salt with an extract of Ocimum basilicum.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
August 1, 2017
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: Lipsticks are tested by a lead indicator solution. A lipstick is swiped across a sheet of wax paper, forming a lipstick sample. The test solution is applied, in droplet form, to the sample of lipstick, and allowed to sit for a period of time so a chemical change can occur in the solution, if there is lead present in the lipstick. A cotton swab is used to absorb the solution, and the tip of the swab picks up a bit of the lipstick sample. A color change is observed in the solution on the swab if lead is present in the lipstick. The amount of lead is determined by what color the solution changes to.
Abstract: The present development is a kit and a method for easily determining the presence of lead on a surface. The kit provides a rhodizonate salt and an aqueous acid mixed together in a container that can deliver a liquid product as a fine particle spray. In a preferred embodiment, the rhodizonate salt is sodium rhodizonate and the aqueous acid is aqueous acetic acid. The method includes mixing sodium rhodizonate and aqueous acetic acid and then delivering it to a surface as a fine particle spray, and monitoring any change of color on the treated surface.
Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
Type:
Grant
Filed:
August 28, 2012
Date of Patent:
August 4, 2015
Assignee:
UNIVERSITY OF KANSAS
Inventors:
Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
Abstract: This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.
Type:
Grant
Filed:
June 22, 2010
Date of Patent:
May 19, 2015
Assignee:
Schlumberger Technology Corporation
Inventors:
Li Jiang, Timothy Gareth John Jones, Andrew Meredith, Markus Pagels, Amilra Prasanna De Silva
Abstract: The present invention encompasses methods and compositions for detecting pathogenic bacteria. Additionally, the present invention encompasses methods and compositions for catalyzing the dismutation of superoxide radicals.
Type:
Grant
Filed:
May 20, 2013
Date of Patent:
April 28, 2015
Assignee:
Washington University
Inventors:
Jeffrey P. Henderson, Chia Hung, Kaveri Chaturvedi
Abstract: A reusable coating for a nanopore structure is disclosed herein. A nanopore structure includes a substrate comprising a nanochannel and a monolayer of a chemical compound disposed onto at least a portion of a surface of the nanochannel. The chemical compound forms a reversible bond with at least one analyte binding compound introduced into the nanochannel. Methods for making and using the reusable coating are also disclosed.
Type:
Application
Filed:
November 4, 2013
Publication date:
April 16, 2015
Applicant:
International Business Machines Corporation
Inventors:
Natalie Gunn, Jose M. Lobez Comeras, Priscilla Rogers, John Wagner
Abstract: A fluorimetric system, apparatus and method are disclosed to measure an analyte concentration in a sample. A sensor reagent housing is also disclosed which comprises a channel and a porous medium having an analysis chemistry reagent, such as a nucleic acid analysis chemistry reagent. The apparatus and system are portable for field use, with an apparatus housing having a size adapted to fit into a user's hand. An apparatus also includes a sensing chamber and cover, a user interface, a light source; a photomultiplier tube, an amplifier, an A/D converter, a memory, and a processor. In various embodiments, the processor performs a data fitting, determines a sample reaction rate parameter, and determines the analyte concentration from a comparison of the sample reaction rate parameter with stored calibration data. The processor may also generate the calibration data and site-specific offset factors, and modify the calibration data using an offset factor.
Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behavior which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilized compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analyzing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
Type:
Grant
Filed:
August 26, 2009
Date of Patent:
April 14, 2015
Assignee:
Schlumberger Technology Corporation
Inventors:
Kay McGuinness, Nathan Lawrence, Andrew Meredith
Abstract: Disclosed is a method of resolving a heavy metal contamination source based on a sequential extraction scheme and an isotope analysis scheme. Pb isotopes are eluted at 5 types of “cation exchange fraction”, “carbonate fraction”, “iron-oxide and manganese hydroxide-fraction”, “organic matters and sulfide fraction”, and “residual fraction” existing at other types and separated from each other in each step. The Pb isotopes are analyzed and the origins of the Pb isotopes are specified in each step. The contamination source of the Pb isotope including 204Pb, 206Pb, and 207Pb is specified from a correlation between a ratio of 206Pb/204Pb obtained from a content of 206Pb and a content of 204Pb and a ratio of 206Pb/207Pb obtained from a content of 206Pb and a content of 207Pb in the Pb isotope.
Type:
Application
Filed:
March 7, 2014
Publication date:
March 19, 2015
Applicant:
KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCES
Abstract: The present invention is concerned with a method of discriminating between, in a surface of a transition metal alloy, transition metals in different oxidation states using surface sensor molecules adapted to associate selectively with one of the transition metals. In particular, the present invention provides a method of identifying degradation in aircraft components such as turbine blades, engine casings and aerofoils. In embodiments, a surface sensor molecule comprising an oxidation state discriminating group, such as an imidazole, and a fluorescein probe is applied in aqueous solution to the surface of a service-run Ni alloy aircraft component. The sensor molecule selectively associates with transition metals in oxidation states greater than zero such that fluorescence imaging can be used to identify areas of degradation.
Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
Type:
Grant
Filed:
March 23, 2012
Date of Patent:
March 10, 2015
Assignee:
University of Kansas
Inventors:
Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
Abstract: Disclosed are methods for determining the redox condition of cementitious materials. The methods are leaching methods that utilize a redox active transition metal indicator that is present in the cementitious material and exhibits variable solubility depending upon the oxidation state of the indicator. When the leaching process is carried out under anaerobic conditions, the presence or absence of the indicator in the leachate can be utilized to determine the redox condition of and location of the oxidation front in the material that has been subjected to the leaching process.
Type:
Application
Filed:
August 22, 2013
Publication date:
February 26, 2015
Applicant:
Savannah River Nuclear Solutions, LLC
Inventors:
Philip M. Almond, Christine A. Langton, David B. Stefanko
Abstract: Provided are automated methods for measuring soluble magnesium concentration in water using fluorescence. The methods employ the use of a pH-buffered liquid and a magnesium coordinating fluorescing reagent. In certain embodiments, the methods may further employ measuring total hardness concentration of the water by displacing any soluble calcium with soluble magnesium and then re-measuring the soluble magnesium concentration. Optionally, the soluble calcium concentration can be determined by subtracting the measured soluble magnesium concentration from the measured total hardness concentration.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
February 17, 2015
Assignee:
Ecolab USA, Inc.
Inventors:
Arthur J. Kahaian, Alexandra Knoth, Hui Li, Rodney H. Banks, Joe L. Schwartz, Sascha J. Welz
Abstract: A method of removing material from a sapphire article is described. In particular, the method comprises the step of providing an initial sapphire layer and reducing the thickness of the layer while not significantly increasing the surface roughness of the layer, Cover plates for electronic device and methods of preparing them are also disclosed, along with a method of analyzing a sapphire article produced by the present method.
Type:
Application
Filed:
August 5, 2014
Publication date:
February 5, 2015
Inventors:
Gopal Prabhu, Venkatesan Murali, Daniel Squiller
Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
January 27, 2015
Assignee:
Lighthouse Medical Limited
Inventors:
William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
Abstract: A general methodology to design label-free fluorescent functional nucleic acid sensors using a vacant site approach and an abasic site approach is described. In one example, a method for designing label-free fluorescent functional nucleic acid sensors (e.g., those that include a DNAzyme, aptamer or aptazyme) that have a tunable dynamic range through the introduction of an abasic site (e.g., dSpacer) or a vacant site into the functional nucleic acids. Also provided is a general method for designing label-free fluorescent aptamer sensors based on the regulation of malachite green (MG) fluorescence. A general method for designing label-free fluorescent catalytic and molecular beacons (CAMBs) is also provided. The methods demonstrated here can be used to design many other label-free fluorescent sensors to detect a wide range of analytes. Sensors and methods of using the disclosed sensors are also provided.
Type:
Grant
Filed:
October 6, 2011
Date of Patent:
January 13, 2015
Assignee:
The Board of Trustees of the University of Illinois
Abstract: An apparatus and process is provided for detecting elemental mercury in soil. A sacrificial electrode of aluminum is inserted below ground to a desired location using direct-push/cone-penetrometer based equipment. The insertion process removes any oxides or previously found mercury from the electrode surface. Any mercury present adjacent the electrode can be detected using a voltmeter which indicates the presence or absence of mercury. Upon repositioning the electrode within the soil, a fresh surface of the aluminum electrode is created allowing additional new measurements.
Abstract: Disclosed herein are chromogenic response polymers and methods and devices that utilize the disclosed polymers which are suitable for use in detecting the presence of and identity of biogenic amines.
Type:
Grant
Filed:
March 24, 2008
Date of Patent:
January 6, 2015
Assignee:
University of South Carolina
Inventors:
John J. Lavigne, Toby Nelson, Marc Maynor
Abstract: An analysis system includes: a creatinine information acquiring section to input creatinine measurement data that indicate a measurement quantity of creatinine in a urine sample; a material ingredient information acquiring section to input material ingredient data that indicate a measured quantity of a material ingredient in the urine sample; and a correcting section to correct the measured quantity of the material ingredient indicated as the material ingredient data, by use of the measured quantity of creatinine indicated as the creatinine measurement data.
Abstract: A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at the porous substrate is greater than the cross-sectional area at the nozzle.
Abstract: A method for analyzing a metal material includes electrolyzing a metal sample in an electrolytic solution, immersing a remaining portion of the metal sample taken out of the electrolytic solution in a dispersible solution to separate at least one substance selected from the group consisting of precipitates and inclusions attached to the remaining portion of the metal sample, filtering the dispersible solution containing the at least one separated substance through filters having straight pores and a porosity of 4% or more to obtain residues trapped on the filters and filtrates, and analyzing at least one of the residues and the filtrates.
Abstract: A detection method and indicator are disclosed that includes quantum dots that fluoresce under illumination of a first light having a first wavelength to indicate the presence of a predetermined condition, and in particular, a corrosion condition. The quantum dots are surrounded by a shell material that under normal conditions reflect the first light and reacts in the presence of the predetermined condition to permit the first light to illuminate the quantum dot to excite the quantum dot to emit a second light having a second wavelength, which when detected, indicates the presence of the predetermined condition.
Type:
Grant
Filed:
March 23, 2011
Date of Patent:
October 7, 2014
Assignee:
The Boeing Company
Inventors:
Keith J. Davis, Nicole L. DeHuff, Morteza Safai
Abstract: The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS.
Type:
Grant
Filed:
February 27, 2007
Date of Patent:
September 23, 2014
Assignees:
Massachusetts General Hospital, Metabolon, Inc.
Inventors:
Lisa A. Paige, Matthew W. Mitchell, Anne Evans, Don Harvan, Kay A. Lawton, Robert Brown, Merit Cudkowicz
Abstract: A method for recovering a metal, capable of recovering a metal easily without requiring the use of an organic medium, is provided. A first complex between a first chelating agent and a metal present in a sample is formed in a first mixture prepared by mixing the first chelating agent and the sample. Then, the first complex is recovered from the first mixture, and a second complex between the metal derived from the first complex and a second chelating agent is formed in a second mixture prepared by mixing the first complex and an aqueous solution of the second chelating agent. The aqueous solution is under the pH conditions where the first chelating agent can be insoluble in the aqueous solution. Then, a liquid fraction containing the second complex is recovered from the second mixture. Thus, the metal can be recovered.
Abstract: In order to provide a reagent kit for detecting LA which can clearly separate a lupus anticoagulant (LA)-positive specimen group from an LA-negative specimen group, it is configured that the reagent kit for detecting LA contains a first clotting time-measuring reagent and a second clotting time-measuring reagent and at least one of the first clotting time-measuring reagent and the second clotting time-measuring reagent contains alkali metal salt. The presence or absence of LA can be determined using the kit.
Abstract: A detection device for molten metal is provided. The detection device includes a sample cup having a cavity configured to receive a sample of molten metal and a blob arranged in the cavity. The blob includes a carbide stabilizing element and a hydrogen releasing material including a hydroxide of an alkaline earth metal. The blob is provided for use in detecting phase change temperatures during solidification of a sample of molten cast iron. The blob is also resistant to moisture gain and moisture loss during transport and storage. A method of detecting phase change temperatures of the molten iron or molten cast iron sample using the blob and a method of manufacturing the blob are also provided.
Type:
Application
Filed:
November 15, 2012
Publication date:
May 15, 2014
Applicant:
HERAEUS ELECTRO-NITE INTERNATIONAL N.V.