Li, Na, K, Rb, Cs, Fr, Be, Mg, Ca, Sr, Ba, Ra Patents (Class 436/79)
  • Patent number: 10718746
    Abstract: A water hardness-measuring method and a fouling prevention method for hardness-measuring device include adding a colorant containing Eriochrome Black T and/or Calmagite and a sulfate ester-type anionic surfactant having a bonding unit derived from a sulfate ester including an alkyl group having 8 to 18 carbon atoms that may have one or more substituent in its chemical formula to a sample water.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: July 21, 2020
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventor: Junichi Takahashi
  • Patent number: 10690648
    Abstract: To provide to a reagent composition used in quantitative measurement of lithium in aqueous solutions such as biological specimens and environmental liquid samples by a simple colorimeter or ultraviolet-visible light spectrophotometer immediately, a reagent composition which permits to measure a concentration of lithium by visual observation, and a method and apparatus for measuring lithium ion by using the reagent. A reagent composition for measuring lithium comprising F28 tetraphenylporphyrin compound as chelating agent, including further a water-soluble organic solvent, a pH modifier and a stabilizer, and a method and apparatus for measuring lithium ion by using the reagent.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 23, 2020
    Assignee: METALLOGENICS Co., Ltd
    Inventors: Takuya Iwabuchi, Tsugikatsu Odashima
  • Patent number: 10620143
    Abstract: A sensor including a fluorinated receptor can be used to identify an analyte through shift in 19F NMR resonance of the receptor when the receptor interacts with the analyte.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: April 14, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Yanchuan Zhao, Lily Chen
  • Patent number: 10571397
    Abstract: Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: February 25, 2020
    Assignee: PHARMACOPHOTONICS, INC.
    Inventors: Ruben Sandoval, Jr., Erinn Reilly, Daniel Meier
  • Patent number: 10345282
    Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 9, 2019
    Assignee: Rapiscan Systems, Inc.
    Inventors: Andrey N. Vilkov, Joseph A. Widjaja, Jack A. Syage
  • Patent number: 9562886
    Abstract: [Problem] To provide to a reagent composition used in quantitative measurement of lithium in aqueous solutions such as biological specimens and environmental liquid samples by a simple colorimeter or ultraviolet-visible light spectrophotometer immediately, a reagent composition which permits to measure a concentration of lithium by visual observation, and a method and apparatus for measuring lithium ion by using the reagent. [Solution] A reagent composition for measuring lithium comprising F28 tetraphenylporphyrin compound as chelating agent, including further a water-soluble organic solvent, a pH modifier and a stabilizer, and a method and apparatus for measuring lithium ion by using the reagent.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: February 7, 2017
    Assignee: METALLOGENICS Co., Ltd
    Inventors: Takuya Iwabuchi, Tsugikatsu Odashima
  • Patent number: 9494666
    Abstract: Methods, computer program products, NMR assays and automated/semi-automated systems measure concentrations of ionized calcium and/or magnesium or other metabolites in clinical biosamples using NMR data obtained from an NMR spectrometer, such as a clinical NMR Analyzer.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: November 15, 2016
    Assignee: LIPSCIENCE, INC.
    Inventors: Elias Jeyarajah, John Contois, Lili Duan, Qun Zhou, Steve Markham, Dennis Bennett, James D. Otvos
  • Patent number: 9341631
    Abstract: Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: May 17, 2016
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Vladimir Martin
  • Patent number: 9314712
    Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces).
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: April 19, 2016
    Assignee: DIONEX CORPORATION
    Inventors: Xiaodong Liu, Christopher A. Pohl, Jinhua Chen, L. Andy Woodruff
  • Patent number: 9222858
    Abstract: Nanoporous polymorphic crystals of CaCO3 were used as sorbent and were applied in the dispersive micro-solid-phase extraction of selected polycyclic aromatic hydrocarbons as target analytes. After separation of the analytes on gas chromatography, they were successfully quantified with external calibration using flame ionization detection. Performance of the dispersive micro-solid-phase extraction was compared with a previously optimized solid-phase extraction technique.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: December 29, 2015
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Abdulmumin A. Nuhu, Chanbasha Basheer, Amjad Ashfaque Shaikh, Abdul Rahman Al-Arfaj
  • Patent number: 9217711
    Abstract: A safer, low-cost practical method of dissolving beryllium or a beryllium compound including beryllium oxide in a sample is disclosed. This method discloses use of acidic solutions under mild heating conditions to dissolve beryllium and its compounds. These solutions may then be used to quantitatively analyze for beryllium so as to be able to determine the amount of beryllium in the sample. These solutions may also be combined with fluorescent dye indicating solutions to determine beryllium by fluorescence. A preferred fluorescent dye indicating solution contains a dye (10-hydroxybenzo[h]quinoline-7-sulfonate) which specifically binds with beryllium under basic conditions.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: December 22, 2015
    Assignee: Berylliant, Inc
    Inventors: Anoop Agrawal, John P. Cronin, Juan Carlos Lopez-Tonazzi
  • Patent number: 9086426
    Abstract: A system and method to generate a concentration gradient eluent flow are described. The concentration gradient eluent flow can include at least two different generants. A liquid can be pumped to an eluent generating device. A first controlling signal can be applied to a first eluent generator to generate a first generant. A second controlling signal can be applied to a second eluent generator to generate a second generant. Either the first and/or the second controlling signal can be varied as a function of time to generate the concentration gradient eluent flow.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 21, 2015
    Assignee: Dionex Corporation
    Inventors: Yan Liu, Petr Jandik, Christopher A. Pohl
  • Patent number: 9034651
    Abstract: This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 19, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Li Jiang, Timothy Gareth John Jones, Andrew Meredith, Markus Pagels, Amilra Prasanna De Silva
  • Publication number: 20150132856
    Abstract: The preparation of silver quantum clusters embedded in organic-templated-boehmite-nanoarchitecture (OTBN) and its use as a sensor for quantity of water flow measured by change of color in visible light upon flow of contaminated water have been provided. Silver quantum clusters-embedded OTBN are highly luminescent. Since the quantum clusters are embedded in the matrix, they are highly stable over a long period of time. The composition described here is utilized in the form of a device for ‘visible/ultraviolet light color change-based detection’ upon passage of water through a water purification device. Upon interaction with ions present in water, luminescent silver clusters undergo chemical transformation to Ag2S nanoparticles. The transformation is reflected in the form of visible color change (from pink to black) and luminescence quenching (from red emission to negligible luminescence).
    Type: Application
    Filed: April 17, 2013
    Publication date: May 14, 2015
    Inventors: Thalappil Pradeep, Leelavathi Annamalai, Mohan Udhaya Sankar, Chaudhary Amrita, n/a Anshup, Thumu Udayabhaskara Rao
  • Patent number: 9005983
    Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behavior which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilized compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analyzing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: April 14, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Kay McGuinness, Nathan Lawrence, Andrew Meredith
  • Publication number: 20150079687
    Abstract: [Problem] To provide to a reagent composition used in quantitative measurement of lithium in aqueous solutions such as biological specimens and environmental liquid samples by a simple colorimeter or ultraviolet-visible light spectrophotometer immediately, a reagent composition which permits to measure a concentration of lithium by visual observation, and a method and apparatus for measuring lithium ion by using the reagent. [Solution] A reagent composition for measuring lithium comprising F28 tetraphenylporphyrin compound as chelating agent, including further a water-soluble organic solvent, a pH modifier and a stabilizer, and a method and apparatus for measuring lithium ion by using the reagent.
    Type: Application
    Filed: April 25, 2012
    Publication date: March 19, 2015
    Applicant: METALLOGENICS CO., LTD.
    Inventors: Takuya Iwabuchi, Tsugikatsu Odashima
  • Publication number: 20150079688
    Abstract: A package comprising a body comprising a first compartment containing a first substance and a second compartment containing a second substance. The package includes a first state in which the first compartment is isolated from the second compartment such that the first substance is separated from the second substance, and a second state in which the first compartment communicates with the second compartment such that the first substance and the second substance combine.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 19, 2015
    Applicant: Ecolab USA Inc.
    Inventors: Arthur J. Kahaian, Sascha J. Weiz, Joe L. Schwartz, Adam J. Bauer, Lyle Sampson
  • Patent number: 8962338
    Abstract: Reagents and methods for determination of calcium within a sample. Specific embodiments include a reagent for determination of calcium comprising a mono-nitro substituted BAPTA-type chelator (BAPTA=1,2-bis(2-aminophenoxy)ethane-N,N,N?,N?-tetraacetic acid). Methods for accurate determination of calcium in a sample, such as a blood, whole blood, plasma or serum or any other aqueous liquid sample including cerebrospinal fluid, lymph, salivary juice or urine. Embodiments are also useful for clinical diagnoses.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 24, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans-Peter Josel, Hans-Joachim Kytzia, Matthias Muecke
  • Patent number: 8956875
    Abstract: Provided are automated methods for measuring soluble magnesium concentration in water using fluorescence. The methods employ the use of a pH-buffered liquid and a magnesium coordinating fluorescing reagent. In certain embodiments, the methods may further employ measuring total hardness concentration of the water by displacing any soluble calcium with soluble magnesium and then re-measuring the soluble magnesium concentration. Optionally, the soluble calcium concentration can be determined by subtracting the measured soluble magnesium concentration from the measured total hardness concentration.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 17, 2015
    Assignee: Ecolab USA, Inc.
    Inventors: Arthur J. Kahaian, Alexandra Knoth, Hui Li, Rodney H. Banks, Joe L. Schwartz, Sascha J. Welz
  • Patent number: 8945931
    Abstract: A low-cost practical method of determining beryllium or a beryllium compound thereof in a sample is disclosed by measuring fluorescence. This method discloses optical filters for use with low cost fluorometers which may be used to quantitatively determine the presence of beryllium. This method may be extended to estimate particle size distribution for particles comprising Beryllium. A method is also disclosed to store solutions for extended period of time so that these materials are stable during transportation and in the labs.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: February 3, 2015
    Assignee: Berylliant, Inc.
    Inventors: Anoop Agrawal, John P. Cronin, Alan G. Goodyear, Juan Carlos Lopez Tonazzi
  • Publication number: 20150010934
    Abstract: A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased level of serum calcium in the sample. An increased level of serum calcium indicates the subject is at increased risk of fatal prostate cancer.
    Type: Application
    Filed: September 24, 2014
    Publication date: January 8, 2015
    Inventors: Gary G. Schwartz, Halcyon G. Skinner
  • Patent number: 8883432
    Abstract: Coelenterazine analogs with different luminescence properties from conventional ones and coelenteramide analogs with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogs modified at the 8-position of coelenterazine and coelenteramide analogs modified at the 2- or 3-position of coelenteramide.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: November 11, 2014
    Assignees: JNC Corporation, National University Corporation Tokyo Medical and Dental University
    Inventors: Satoshi Inouye, Yuiko Sahara, Takamitsu Hosoya
  • Publication number: 20140329250
    Abstract: The invention provides calcium-binding photoproteins which can detect light emission with a higher sensitivity. The proteins of the invention comprising the amino acid sequence of SEQ ID NO: 2 can be used for the detection and measurement of calcium ions. The proteins of the invention are useful as reporter proteins, luminescent markers, etc. The polynucleotides of the invention are useful as reporter genes, etc.
    Type: Application
    Filed: May 30, 2014
    Publication date: November 6, 2014
    Inventors: Satoshi INOUYE, Yuiko SAHARA
  • Patent number: 8828728
    Abstract: An aquatic environment monitoring system and method that includes correction for adverse conditions in the monitoring system involving the development of confidence levels for certain conditions in the monitoring system using stored information related to the aquatic environment and/or the monitoring system. Corrections to adverse conditions may be made by the environment monitoring system automatically by the monitoring system and manually via communications to a user of the system.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: September 9, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Publication number: 20140242708
    Abstract: A system and method for determining a remaining processing capacity of a scrubber having a flow path and a processing material disposed along the flow path. A device may comprise a plurality of optical sensors disposed within the processing material and arranged along the flow path, a light source, and a processor for determining the capacity according to signals received from the optical sensor. The device may be used to illuminate processing material adjacent to each optical sensor using the light source, measure a light value reflected by the processing material at each optical sensor, and determine the remaining processing capacity of the scrubber, using the processor, based on the measured light value. Devices may comprise a memory, such as a non-volatile memory to allow multiple uses of a scrubber without reloading with fresh processing material.
    Type: Application
    Filed: April 6, 2012
    Publication date: August 28, 2014
    Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
    Inventors: Clas Erik Gunnar Lundgren, Ronald M. Okupski
  • Patent number: 8796032
    Abstract: A method for determining the content of calcium element in an ore is provided. It includes: decomposing the ore with hydrochloric acid and nitric acid under heating condition, adding perchloric acid, cooling, adding a small amount of water and boiling the solution to dissolve the salts, then cooling, diluting to the constant volume, filtering into a dry beaker with dry filter-paper, masking interfering ions with triethanolamine, adjusting the pH value of the solution with KOH, using calcein-thymolphthalein as indicator, and determinating the content of calcium with EDTA titrimetry.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: August 5, 2014
    Assignee: Jiangxi Rare Earth and Rare Metals Tungsten Group Holding Co Ltd.
    Inventors: Yulan Liang, Ling Peng, Zhijian Zhao
  • Patent number: 8784748
    Abstract: A dry test strip for measuring calcium is comprising a support, a reagent layer provided on the support, and a reagent holding layer provided on the reagent layer, and containing, as reagents, o-cresolphthalene complexone, a magnesium selective masking agent, and a pH buffer for adjusting the pH of the environment for reaction of the o-cresolphthalene complexone with calcium to 10.0-11.0, wherein such reagents are present in either the reagent layer or the reagent holding layer or the both layers.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: July 22, 2014
    Assignee: Arkray, Inc.
    Inventor: Tsutomu Nakamura
  • Publication number: 20140186965
    Abstract: A safer, low-cost practical method of dissolving beryllium or a beryllium compound including beryllium oxide in a sample is disclosed. This method discloses use of acidic solutions under mild heating conditions to dissolve beryllium and its compounds. These solutions may then be used to quantitatively analyze for beryllium so as to be able to determine the amount of beryllium in the sample. These solutions may also be combined with fluorescent dye indicating solutions to determine beryllium by fluorescence. A preferred fluorescent dye indicating solution contains a dye (10-hydroxybenzo[h]quinoline-7-sulfonate) which specifically binds with beryllium under basic conditions.
    Type: Application
    Filed: February 14, 2014
    Publication date: July 3, 2014
    Inventors: Anoop Agrawal, John P. Cronin, Juan Carlos Lopez-Tonazzi
  • Patent number: 8765921
    Abstract: There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: July 1, 2014
    Assignees: JNC Corporation, Tokyo Institute of Technology
    Inventors: Satoshi Inouye, Yuiko Sahara, Rie Iimori, Takamitsu Hosoya
  • Patent number: 8759108
    Abstract: In order to provide a reagent kit for detecting LA which can clearly separate a lupus anticoagulant (LA)-positive specimen group from an LA-negative specimen group, it is configured that the reagent kit for detecting LA contains a first clotting time-measuring reagent and a second clotting time-measuring reagent and at least one of the first clotting time-measuring reagent and the second clotting time-measuring reagent contains alkali metal salt. The presence or absence of LA can be determined using the kit.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: June 24, 2014
    Assignee: Sysmex Corporation
    Inventors: Masahiro Okuda, Kazuyo Yoshida, Osamu Kumano
  • Patent number: 8709818
    Abstract: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: April 29, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michael P. Caulfield, Richard E. Reitz, Shuguang Li, Gloria Kwangja Lee, Ronald Krauss, Patricia J. Blanche, W. Henry Benner, Earl Cornell
  • Patent number: 8709815
    Abstract: Methods and devices are disclosed providing techniques for measuring the amount of biodiesel in a fuel sample. The methods may be used in the field without the use of laboratory equipment. The biodiesel in the sample is converted to the corresponding free acid which can be isolated and quantified to provide information regarding the amount of biodiesel in the original sample.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: April 29, 2014
    Assignee: Dexsil Corporation
    Inventors: Theodore B. Lynn, Lawrence M. Sacramone
  • Patent number: 8691589
    Abstract: The method of the present disclosure determines whether a target DNA forms a G-quadruplex using a phenomenon in which thioflavin T generates a strong fluorescence when reacted with the G-quadruplex in the presence of potassium ions.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: April 8, 2014
    Assignee: Panasonic Corporation
    Inventor: Daisuke Miyoshi
  • Publication number: 20140057312
    Abstract: A compound represented by the formula (I) (one of substituents represented by R1 is a trapping group for an object substance for measurement; R2 and R3 represent hydrogen, alkyl, or halogen; R4 and R5 represent alkyl or aryl; R6 and R7 represent hydrogen, alkyl, or halogen; R8 represents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl, and X represents silicon, germanium, or tin, which can be used as a fluorescent probe that enables red color bioimaging using intramolecular photoinduced electron transfer.
    Type: Application
    Filed: February 17, 2012
    Publication date: February 27, 2014
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Tetsuo Nagano, Kenjiro Hanaoka, Yuichiro Koide, Takahiro Egawa
  • Patent number: 8642281
    Abstract: Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogues modified at the 8-position of coelenterazine and coelenteramide analogues modified at the 2- or 3-position of coelenteramide.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: February 4, 2014
    Assignees: JNC Corporation, National University Corporation Tokyo Medical and Dental University
    Inventors: Satoshi Inouye, Yuiko Sahara, Takamitsu Hosoya
  • Publication number: 20140024058
    Abstract: There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).
    Type: Application
    Filed: August 22, 2013
    Publication date: January 23, 2014
    Applicants: Tokyo Institute Of Technology, JNC Corporation
    Inventors: Satoshi INOUYE, Yuiko Sahara, Rie Iimori, Takamitsu Hosoya
  • Publication number: 20140017796
    Abstract: An aquatic environment monitoring system that includes chemical indicators that are dyes immobilized in an immobilizing medium, such as a hydrogel, and supported on a holder such that an optical reader may be used to illuminate the indicator dyes. The chemical indicator dyes include chemical indicator dyes that are sensitive for detecting calcium, magnesium, and carbon dioxide present in the aquatic environment.
    Type: Application
    Filed: December 13, 2012
    Publication date: January 16, 2014
    Applicant: STEP AHEAD INNOVATIONS, INC.
    Inventor: STEP AHEAD INNOVATIONS, INC.
  • Publication number: 20130344607
    Abstract: The present invention relates to ?-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion. Fluoroionophoric compounds of the general formula I are described Ionophore-?-Linker-Fluorophore??(I) wherein the Ionophore is an anilino containing crown ether or cryptand with one or more anilino donor moieties as electron donors, forming a stable complex with an alkali metal ion the ?-Linker is an aromatic or heteroaromatic conjugative linking moiety, and the Fluorophore is an electron acceptor moiety. Variation of the ionophoric unit offers a broad spectrum of detectable K+ and Na+-concentrations, ranging from high concentration around 800 mM down to very low concentrations around 3 mM.
    Type: Application
    Filed: March 9, 2012
    Publication date: December 26, 2013
    Applicant: UNIVERSITAET POTSDAM
    Inventors: Sandra Ast, Hans-Juergen Holdt
  • Publication number: 20130330829
    Abstract: Systems and methods are provided for predicting the likelihood of acute kidney injury. An input interface is configured to receive a plurality of features derived from the results of a post-surgical metabolic blood panel and either a pre-surgical metabolic blood panel or a perisurgical metabolic blood panel. A predictive model is configured to calculate a parameter representing a likelihood of acute kidney injury from the plurality of features. A user interface is configured to provide the calculated parameter to a user in a human comprehensible form.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Inventor: Sevag G. Demirjian
  • Publication number: 20130280813
    Abstract: Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes.
    Type: Application
    Filed: June 20, 2013
    Publication date: October 24, 2013
    Inventors: Jonathan ROTHBERG, Wolfgang HINZ
  • Patent number: 8548772
    Abstract: An automatic method for identifying biological samples that are collected using the wrong blood preservative for subsequent analytical testing. The method also provides for identification and/or suppression of certain analytical test results that are substantially or partly adversely affected. The invention is particularly suited for use in point-of-care medical diagnostic testing.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: October 1, 2013
    Assignee: Abbott Point of Care Inc.
    Inventors: Eric Brouwer, Jody Ann Tirinato, Michael P. Zelin
  • Publication number: 20130244263
    Abstract: The invention is directed to a method of identifying a patient undergoing periodic hemodialysis treatments at increased risk for death that includes determining at least one of the patient's clinical or biochemical parameters, consisting of serum bicarbonate concentration level, serum potassium concentration level, serum calcium concentration level, hemoglobin concentration level, serum phosphorus concentration level, neutrophil to lymphocyte ratio, equilibrated normalized protein catabolic rate (enPCR), equilibrated fractional clearance of total body water by dialysis and residual kidney function (eKdrt/V), EPO resistance index, transferrin saturation index, serum ferritin concentration level, serum creatinine concentration level, platelet count, Aspartat-Aminotransferase level, and Alanin-Aminotransferase level at periodic hemodialysis treatments, and identifying a patient as having an increased risk for death if the patient has a significant change in the rate of change of at least one of the patient's cli
    Type: Application
    Filed: December 1, 2011
    Publication date: September 19, 2013
    Inventors: Peter Kotanko, Stephan Thijssen, Len Usvyat, Nathan W. Levin
  • Patent number: 8507284
    Abstract: The present invention provides an apparatus and rapid methods for extracting strontium ions from urine to provide a concentrated and purified strontium-90 extract suitable for scintillation measurements. The methods remove organic compounds, pigments, and alkali metal ions that can interfere with quantitative determination of strontium-90 in urine.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: August 13, 2013
    Assignee: UChicago Argonne, LLC
    Inventors: Michael D. Kaminski, Carol J. Mertz, Ilya A. Shkrob, Mark L. Dietz, Cory A. Hawkins
  • Patent number: 8476006
    Abstract: The present technology provides a cell based assay for identifying compounds that modulate store-operated ionic calcium levels using itpr mutant cell lines, such as itpr-ku cells, which have abnormal ionic calcium levels.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: July 2, 2013
    Assignee: National Center for Biological Sciences
    Inventors: Gayatri Venkiteswaran, Gaiti Hasan
  • Patent number: 8450117
    Abstract: A method of determining beryllium or a beryllium compound thereof in a sample is disclosed by measuring fluorescence. This method discloses improved sample preparation methods, particularly for refractory beryllium materials. The method also discloses methods to improve the detection limit of beryllium including use of optical filters with specific characteristics for selecting the emission wavelengths of the fluorescence signal.
    Type: Grant
    Filed: December 24, 2010
    Date of Patent: May 28, 2013
    Assignee: Berylliant Inc.
    Inventors: Anoop Agrawal, John P. Cronin, Juan Carlos Lopez Tonazzi
  • Publication number: 20130116138
    Abstract: Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, ? carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or GBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule.
    Type: Application
    Filed: January 28, 2011
    Publication date: May 9, 2013
    Applicants: Archer-Daniels-Midland Company, Iowa State University Research Foundation, Inc.
    Inventors: Thomas P. Binder, Aragula Gururaj Rao, Yasufumi Yamamoto, Paul Hanke
  • Patent number: 8409863
    Abstract: A system to selectively deliver relatively small analyte molecules of interest to a SERS-active nanoparticle surface while excluding dozens to hundreds of other species in the environment. In particular, the present invention provides a permselective film that renders the particles of interest as viable small molecule optically addressable sensors.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: April 2, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Michael J. Natan, Marcelo Eduardo Piotti
  • Patent number: 8388930
    Abstract: A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope 41Ca by the patient, obtaining a sample of the radioactive calcium isotope 41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: March 5, 2013
    Assignees: Lawrence LIvermore National Security, LLC, The Regents of the University of California
    Inventors: Darren J. Hillegonds, John S. Vogel, Robert L. Fitzgerald, Leonard J. Deftos, David Herold, Douglas W. Burton
  • Publication number: 20130052742
    Abstract: The invention provides a single colorimetric reagent for the measurement of oxidising agents such as free chlorine in a liquid sample which contains a food dye, whereby the oxidising agent undergoes a reaction with said food dye. A preferred food dye is Brilliant Blue FCF. There is also provided a control system for regulating the volume of reagent added to a fixed volume of sample according to a control algorithm to give a chosen excess of a reagent compound beyond that required to stoichiometrically react with the target analyte in the sample. Also disclosed are single reagents for colorimetric determination of total alkalinity and calcium hardness.
    Type: Application
    Filed: May 4, 2011
    Publication date: February 28, 2013
    Applicant: AQUALYSIS PTY LTD
    Inventors: Stephen Charles Davis, John David Petty
  • Publication number: 20130040392
    Abstract: Various agents for improving adhesion of cold end coatings on glass surfaces are described Also described are agents for improving bonding between cold end coatings and organic inks. And, methods and related detection solutions for detecting the presence of cold end coatings on a substrate such as a glass bottle are disclosed. Additionally, particular additives and primers are described that can be applied onto cold end coatings for improving adhesion thereto.
    Type: Application
    Filed: January 21, 2011
    Publication date: February 14, 2013
    Applicant: FERRO CORPORATION
    Inventors: Cindy Pankiewicz, Thirumalai Duraisamy, Bertram Gardner, Ian Dudas, David C. Kapp, Enos A. Axtell, III, George E. Sakoske